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Conserved domains on  [gi|395455073|ref|NP_001257453|]
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homeobox protein OTX2 isoform b [Homo sapiens]

Protein Classification

homeobox protein( domain architecture ID 11079031)

homeobox protein similar to Otx1 and Otx2 which are vertebrate homologs of the Drosophila gap gene orthodenticle and may play a role in the specification or differentiation of neurons in the deep layers of the cerebral cortex

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TF_Otx pfam03529
Otx1 transcription factor;
153-234 8.61e-31

Otx1 transcription factor;


:

Pssm-ID: 427350  Cd Length: 91  Bit Score: 110.77  E-value: 8.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395455073  153 SPASISPLSDPLSTSS-SCMQRS--------YPMTYTQASGYSQGY-AGSTSYFGGMDCGSYLTPMHHQLPGPGAtLSPM 222
Cdd:pfam03529   1 SPASISPLPDPLAPSSaSCMQRSvsstasasYPMSYGQASAYSQGYpAGSSSYFGGVDCGSYLSPMHSQLHHPHQ-LSPM 79

                          90
                  ....*....|..
gi 395455073  223 GTNAVTSHLNQS 234
Cdd:pfam03529  80 TASSMGGHLHQH 91
Homeodomain pfam00046
Homeodomain;
39-94 9.51e-27

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 9.51e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 395455073   39 RRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
 
Name Accession Description Interval E-value
TF_Otx pfam03529
Otx1 transcription factor;
153-234 8.61e-31

Otx1 transcription factor;


Pssm-ID: 427350  Cd Length: 91  Bit Score: 110.77  E-value: 8.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395455073  153 SPASISPLSDPLSTSS-SCMQRS--------YPMTYTQASGYSQGY-AGSTSYFGGMDCGSYLTPMHHQLPGPGAtLSPM 222
Cdd:pfam03529   1 SPASISPLPDPLAPSSaSCMQRSvsstasasYPMSYGQASAYSQGYpAGSSSYFGGVDCGSYLSPMHSQLHHPHQ-LSPM 79

                          90
                  ....*....|..
gi 395455073  223 GTNAVTSHLNQS 234
Cdd:pfam03529  80 TASSMGGHLHQH 91
Homeodomain pfam00046
Homeodomain;
39-94 9.51e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 9.51e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 395455073   39 RRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 38-94 5.05e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.93  E-value: 5.05e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 395455073    38 QRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 39-94 6.58e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 91.54  E-value: 6.58e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 395455073  39 RRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
36-94 1.03e-14

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 70.16  E-value: 1.03e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 395455073  36 RKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:COG5576   49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Name Accession Description Interval E-value
TF_Otx pfam03529
Otx1 transcription factor;
153-234 8.61e-31

Otx1 transcription factor;


Pssm-ID: 427350  Cd Length: 91  Bit Score: 110.77  E-value: 8.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 395455073  153 SPASISPLSDPLSTSS-SCMQRS--------YPMTYTQASGYSQGY-AGSTSYFGGMDCGSYLTPMHHQLPGPGAtLSPM 222
Cdd:pfam03529   1 SPASISPLPDPLAPSSaSCMQRSvsstasasYPMSYGQASAYSQGYpAGSSSYFGGVDCGSYLSPMHSQLHHPHQ-LSPM 79

                          90
                  ....*....|..
gi 395455073  223 GTNAVTSHLNQS 234
Cdd:pfam03529  80 TASSMGGHLHQH 91
Homeodomain pfam00046
Homeodomain;
39-94 9.51e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 9.51e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 395455073   39 RRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 38-94 5.05e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.93  E-value: 5.05e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 395455073    38 QRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 39-94 6.58e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 91.54  E-value: 6.58e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 395455073  39 RRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
36-94 1.03e-14

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 70.16  E-value: 1.03e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 395455073  36 RKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 94
Cdd:COG5576   49 SPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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