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Conserved domains on  [gi|387762597|ref|NP_001248391|]
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DNA-dependent metalloprotease SPRTN isoform c [Homo sapiens]

Protein Classification

SprT family zinc-dependent metalloprotease( domain architecture ID 141001)

SprT family zinc-dependent metalloprotease, which contains an HExxH motif characteristic of zinc metallopeptidases

CATH:  3.30.2010.10
EC:  3.4.-.-
Gene Ontology:  GO:0008237|GO:0006508|GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YgjP-like super family cl19237
YgjP-like, metallopeptidase domain; This is a conserved domain containing the catalytic ...
 43-169 5.94e-26

YgjP-like, metallopeptidase domain; This is a conserved domain containing the catalytic zinc-metallopeptidase (HExxH) catalytic motif. Proteins containing this domain are found in some archaebacteria, as well as Helicobacter pylori. The proteins are 190-240 amino acids long, with the C terminus being the most conserved region, containing three conserved histidines. This domain is found in YgjP from E. coli, a predicted metal-dependent hydrolase that hydrolyses UTP to UMP and diphosphate in vitro; and in MJ0123 from Methanocaldococcus jannaschii (also referred to as projannalysin).


The actual alignment was detected with superfamily member smart00731:

Pssm-ID: 473153 [Multi-domain]  Cd Length: 146  Bit Score: 97.40  E-value: 5.94e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387762597    43 PDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAGICSYegkgGMCSIRLSEPLLKLRPRKDLVEV-------------- 108
Cdd:smart00731   1 QELTQRLEDASLRVFGRKLPHPKVVWNKRLRKTGGRCLL----KSAEIRLNPKLLTENGRDRLRETllhelchaalylfg 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387762597   109 -----------------------YHTFHDEVdeYRRHWWRCNgPCQHRppyYGYVKRATNRepsahdyWWAEHQKtCGGT 165
Cdd:smart00731  77 rgyghgdewkrwmrqvnglfperCHTFLIES--VKKYPYRCT-GCGQR---YLRVRRSNNV-------SRYRCGK-CGGK 142


                   ....
gi 387762597   166 YIKI 169
Cdd:smart00731 143 LILI 146
 
Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
 43-169 5.94e-26

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 97.40  E-value: 5.94e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387762597    43 PDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAGICSYegkgGMCSIRLSEPLLKLRPRKDLVEV-------------- 108
Cdd:smart00731   1 QELTQRLEDASLRVFGRKLPHPKVVWNKRLRKTGGRCLL----KSAEIRLNPKLLTENGRDRLRETllhelchaalylfg 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387762597   109 -----------------------YHTFHDEVdeYRRHWWRCNgPCQHRppyYGYVKRATNRepsahdyWWAEHQKtCGGT 165
Cdd:smart00731  77 rgyghgdewkrwmrqvnglfperCHTFLIES--VKKYPYRCT-GCGQR---YLRVRRSNNV-------SRYRCGK-CGGK 142


                   ....
gi 387762597   166 YIKI 169
Cdd:smart00731 143 LILI 146
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
 45-108 2.63e-18

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 76.54  E-value: 2.63e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 387762597   45 LQALFVQFNDQFFWGQL-EAVEVKWSVRMTLCAGICSYEGKggmCSIRLSEPLLKLRPRKDLVEV 108
Cdd:pfam10263   1 LEELFQQLNDEFFRGFLlPGVSVRWSKRLRTTAGRAHLKRK---NEIRLSEPLLDENPEEFLRET 62
 
Name Accession Description Interval E-value
SprT smart00731
SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved ...
 43-169 5.94e-26

SprT homologues; Predicted to have roles in transcription elongation. Contains a conserved HExxH motif, indicating a metalloprotease function.


Pssm-ID: 214794 [Multi-domain]  Cd Length: 146  Bit Score: 97.40  E-value: 5.94e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387762597    43 PDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAGICSYegkgGMCSIRLSEPLLKLRPRKDLVEV-------------- 108
Cdd:smart00731   1 QELTQRLEDASLRVFGRKLPHPKVVWNKRLRKTGGRCLL----KSAEIRLNPKLLTENGRDRLRETllhelchaalylfg 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387762597   109 -----------------------YHTFHDEVdeYRRHWWRCNgPCQHRppyYGYVKRATNRepsahdyWWAEHQKtCGGT 165
Cdd:smart00731  77 rgyghgdewkrwmrqvnglfperCHTFLIES--VKKYPYRCT-GCGQR---YLRVRRSNNV-------SRYRCGK-CGGK 142


                   ....
gi 387762597   166 YIKI 169
Cdd:smart00731 143 LILI 146
SprT-like pfam10263
SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The ...
 45-108 2.63e-18

SprT-like family; This family represents a domain found in eukaryotes and prokaryotes. The domain contains a characteriztic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.


Pssm-ID: 463033  Cd Length: 106  Bit Score: 76.54  E-value: 2.63e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 387762597   45 LQALFVQFNDQFFWGQL-EAVEVKWSVRMTLCAGICSYEGKggmCSIRLSEPLLKLRPRKDLVEV 108
Cdd:pfam10263   1 LEELFQQLNDEFFRGFLlPGVSVRWSKRLRTTAGRAHLKRK---NEIRLSEPLLDENPEEFLRET 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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