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Conserved domains on  [gi|387157914|ref|NP_001248340|]
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splicing factor, suppressor of white-apricot homolog isoform 1 [Homo sapiens]

Protein Classification

DRY_EERY and SWAP domain-containing protein( domain architecture ID 13763490)

protein containing domains DRY_EERY, SWAP, and rpsP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 35-155 5.06e-45

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


:

Pssm-ID: 462881  Cd Length: 129  Bit Score: 158.25  E-value: 5.06e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387157914    35 LLVFGYACKLFRDDERALAQEQGQHLIPWMGDHKILIDRYDGRGHLHDLSEYDAEYStwNRDYQLSEEEARIEALCDEER 114
Cdd:pfam09750    1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEAGRS--ARLSELTSEEEEEERECNYER 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 387157914   115 YLALHTD----------LLEEEARQEEEYKRLSEALAEDGSYNAVGFTYGS 155
Cdd:pfam09750   79 YRDLIKNefegvseeeeLKRIYQEEQFGAKRLSAAKKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 209-262 4.73e-16

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 73.01  E-value: 4.73e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 387157914    209 HAIIERTASFVCRQGAQFEIMLKAKQARNSQFDFLRFDHYLNPYYKFIQKAMKE 262
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 457-508 8.00e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 69.54  E-value: 8.00e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 387157914    457 QPVIDKLAEYVARNGLKFETSVRAK--NDQRFEFLQPWHQYNAYYEFKKQFFLQ 508
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERerNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
rpsP super family cl36390
30S ribosomal protein S16; Provisional
 637-718 4.84e-03

30S ribosomal protein S16; Provisional


The actual alignment was detected with superfamily member PRK14521:

Pssm-ID: 237744 [Multi-domain]  Cd Length: 186  Bit Score: 39.38  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387157914  637 KKPQLTQEELEAKQA--KQKLEDRLAAAArEKLAQASKESKEKQLQAERKRKAALFLQTLKNPLPEAEAGKIEESPFSVE 714
Cdd:PRK14521   90 AKGAFTEAQAEAKFEawKEEKEGKVNAKK-DKLSKAKKAAKKAALEAEKKVNEARAEAVAEKKAAEAAAVAAEEAAAAEE 168


                  ....
gi 387157914  715 ESST 718
Cdd:PRK14521  169 EEAE 172
 
Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 35-155 5.06e-45

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


Pssm-ID: 462881  Cd Length: 129  Bit Score: 158.25  E-value: 5.06e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387157914    35 LLVFGYACKLFRDDERALAQEQGQHLIPWMGDHKILIDRYDGRGHLHDLSEYDAEYStwNRDYQLSEEEARIEALCDEER 114
Cdd:pfam09750    1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEAGRS--ARLSELTSEEEEEERECNYER 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 387157914   115 YLALHTD----------LLEEEARQEEEYKRLSEALAEDGSYNAVGFTYGS 155
Cdd:pfam09750   79 YRDLIKNefegvseeeeLKRIYQEEQFGAKRLSAAKKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 209-262 4.73e-16

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 73.01  E-value: 4.73e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 387157914    209 HAIIERTASFVCRQGAQFEIMLKAKQARNSQFDFLRFDHYLNPYYKFIQKAMKE 262
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 210-254 4.95e-15

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 69.85  E-value: 4.95e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 387157914   210 AIIERTASFVCRQGAQFEIMLKAKQARNSQFDFLR-FDHYLNPYYK 254
Cdd:pfam01805    1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFdPDDPLHAYYR 46
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 457-508 8.00e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 69.54  E-value: 8.00e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 387157914    457 QPVIDKLAEYVARNGLKFETSVRAK--NDQRFEFLQPWHQYNAYYEFKKQFFLQ 508
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERerNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 459-502 3.93e-12

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 61.77  E-value: 3.93e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 387157914   459 VIDKLAEYVARNGLKFETSVRAK--NDQRFEFL-QPWHQYNAYYEFK 502
Cdd:pfam01805    2 IIKKTAQFVARNGPEFEALLMEReeRNPQFDFLfDPDDPLHAYYRWK 48
rpsP PRK14521
30S ribosomal protein S16; Provisional
 637-718 4.84e-03

30S ribosomal protein S16; Provisional


Pssm-ID: 237744 [Multi-domain]  Cd Length: 186  Bit Score: 39.38  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387157914  637 KKPQLTQEELEAKQA--KQKLEDRLAAAArEKLAQASKESKEKQLQAERKRKAALFLQTLKNPLPEAEAGKIEESPFSVE 714
Cdd:PRK14521   90 AKGAFTEAQAEAKFEawKEEKEGKVNAKK-DKLSKAKKAAKKAALEAEKKVNEARAEAVAEKKAAEAAAVAAEEAAAAEE 168


                  ....
gi 387157914  715 ESST 718
Cdd:PRK14521  169 EEAE 172
 
Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 35-155 5.06e-45

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


Pssm-ID: 462881  Cd Length: 129  Bit Score: 158.25  E-value: 5.06e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387157914    35 LLVFGYACKLFRDDERALAQEQGQHLIPWMGDHKILIDRYDGRGHLHDLSEYDAEYStwNRDYQLSEEEARIEALCDEER 114
Cdd:pfam09750    1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEAGRS--ARLSELTSEEEEEERECNYER 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 387157914   115 YLALHTD----------LLEEEARQEEEYKRLSEALAEDGSYNAVGFTYGS 155
Cdd:pfam09750   79 YRDLIKNefegvseeeeLKRIYQEEQFGAKRLSAAKKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 209-262 4.73e-16

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 73.01  E-value: 4.73e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 387157914    209 HAIIERTASFVCRQGAQFEIMLKAKQARNSQFDFLRFDHYLNPYYKFIQKAMKE 262
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 210-254 4.95e-15

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 69.85  E-value: 4.95e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 387157914   210 AIIERTASFVCRQGAQFEIMLKAKQARNSQFDFLR-FDHYLNPYYK 254
Cdd:pfam01805    1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFdPDDPLHAYYR 46
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 457-508 8.00e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 69.54  E-value: 8.00e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 387157914    457 QPVIDKLAEYVARNGLKFETSVRAK--NDQRFEFLQPWHQYNAYYEFKKQFFLQ 508
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERerNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 459-502 3.93e-12

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 61.77  E-value: 3.93e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 387157914   459 VIDKLAEYVARNGLKFETSVRAK--NDQRFEFL-QPWHQYNAYYEFK 502
Cdd:pfam01805    2 IIKKTAQFVARNGPEFEALLMEReeRNPQFDFLfDPDDPLHAYYRWK 48
rpsP PRK14521
30S ribosomal protein S16; Provisional
 637-718 4.84e-03

30S ribosomal protein S16; Provisional


Pssm-ID: 237744 [Multi-domain]  Cd Length: 186  Bit Score: 39.38  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387157914  637 KKPQLTQEELEAKQA--KQKLEDRLAAAArEKLAQASKESKEKQLQAERKRKAALFLQTLKNPLPEAEAGKIEESPFSVE 714
Cdd:PRK14521   90 AKGAFTEAQAEAKFEawKEEKEGKVNAKK-DKLSKAKKAAKKAALEAEKKVNEARAEAVAEKKAAEAAAVAAEEAAAAEE 168


                  ....
gi 387157914  715 ESST 718
Cdd:PRK14521  169 EEAE 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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