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Conserved domains on  [gi|375331903|ref|NP_001243583|]
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zinc finger protein 43 isoform 4 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-689 4.84e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 4.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 221 YKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRI 298
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 299 HTAE-KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEkpykcEECGKAFNWPSTLT 377
Cdd:COG5048  114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 378 KHNRIHTGEKPYKCEvCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWS 457
Cdd:COG5048  189 SSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 458 SKLTEHKITHTGEkpykceecgkafnhfsilTKHKRIHTgekPYKCEECGKAFTQSSNLTTHK--KIHTGEKFYKCEE-- 533
Cdd:COG5048  268 ASSQSSSPNESDS------------------SSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpy 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 534 --CGKAFTQSSNLTTHKKIHTGGKPYKCEECgkafnqfSTLTKHKIIHTEEKPykceecgkafkwsSTLTKHKIIHTGEK 611
Cdd:COG5048  327 slCGKLFSRNDALKRHILLHTSISPAKEKLL-------NSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKK 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 612 PYKCE-ECGKAFKLSSTLSTHKIIHTGEKP--YKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKaFNYSSHLNTHK 688
Cdd:COG5048  387 SETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                 .
gi 375331903 689 R 689
Cdd:COG5048  466 K 466
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
668-729 1.65e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.65e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 375331903 668 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKC--KECGKAFNQYSNLTTHNKIHTGEKLYKPED 729
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-689 4.84e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 4.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 221 YKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRI 298
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 299 HTAE-KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEkpykcEECGKAFNWPSTLT 377
Cdd:COG5048  114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 378 KHNRIHTGEKPYKCEvCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWS 457
Cdd:COG5048  189 SSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 458 SKLTEHKITHTGEkpykceecgkafnhfsilTKHKRIHTgekPYKCEECGKAFTQSSNLTTHK--KIHTGEKFYKCEE-- 533
Cdd:COG5048  268 ASSQSSSPNESDS------------------SSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpy 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 534 --CGKAFTQSSNLTTHKKIHTGGKPYKCEECgkafnqfSTLTKHKIIHTEEKPykceecgkafkwsSTLTKHKIIHTGEK 611
Cdd:COG5048  327 slCGKLFSRNDALKRHILLHTSISPAKEKLL-------NSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKK 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 612 PYKCE-ECGKAFKLSSTLSTHKIIHTGEKP--YKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKaFNYSSHLNTHK 688
Cdd:COG5048  387 SETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                 .
gi 375331903 689 R 689
Cdd:COG5048  466 K 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
488-512 9.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.65e-04
                          10        20
                  ....*....|....*....|....*
gi 375331903  488 LTKHKRIHTGEKPYKCEECGKAFTQ 512
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
668-729 1.65e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.65e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 375331903 668 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKC--KECGKAFNQYSNLTTHNKIHTGEKLYKPED 729
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
683-708 3.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.26e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331903  683 HLNTHKRIHTKEQPYKCKECGKAFNQ 708
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-689 4.84e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 4.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 221 YKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRI 298
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 299 HTAE-KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEkpykcEECGKAFNWPSTLT 377
Cdd:COG5048  114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 378 KHNRIHTGEKPYKCEvCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWS 457
Cdd:COG5048  189 SSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 458 SKLTEHKITHTGEkpykceecgkafnhfsilTKHKRIHTgekPYKCEECGKAFTQSSNLTTHK--KIHTGEKFYKCEE-- 533
Cdd:COG5048  268 ASSQSSSPNESDS------------------SSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpy 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 534 --CGKAFTQSSNLTTHKKIHTGGKPYKCEECgkafnqfSTLTKHKIIHTEEKPykceecgkafkwsSTLTKHKIIHTGEK 611
Cdd:COG5048  327 slCGKLFSRNDALKRHILLHTSISPAKEKLL-------NSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKK 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 612 PYKCE-ECGKAFKLSSTLSTHKIIHTGEKP--YKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKaFNYSSHLNTHK 688
Cdd:COG5048  387 SETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                 .
gi 375331903 689 R 689
Cdd:COG5048  466 K 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
315-717 5.00e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 5.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 315 SRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEKPYKC--EECGKAFNWPSTLTKHNRIHTGEKPYKCE 392
Cdd:COG5048   16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 393 VCGKAFNQFSNLTTHKRIHTAE-KPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEEC--------------------- 450
Cdd:COG5048   96 KSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpans 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 451 --GKAFKWSSKLTEHKITHTGEKPYKCEECGKaFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKF 528
Cdd:COG5048  176 lsKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 529 YKCEECGKAFTQSSNLTTHKKIHTG-------GKPYKCEECGKAFNQFSTLTKHK--IIHTEE--KPYKCEE--CGKAFK 595
Cdd:COG5048  255 SSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFS 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 596 WSSTLTKHKIIHTGEKPYKC--EECGKAF------KLSSTLSTHKIIHTGEKPYKCE-KCGKAFNRSSNLIEHKKIHTGE 666
Cdd:COG5048  335 RNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSF 414

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 375331903 667 QP--YKCEECGKAFNYSSHLNTHKRIHTKEQPYKCkECGKAFNQYSNLTTHNK 717
Cdd:COG5048  415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-508 2.64e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 2.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 138 KCEKCGKAFNCPSIITKHKRINTGEKPYTCEECGKVFNWS----------------SRLTTHKKNYTRYKLYKCE----- 196
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelsrhlrthhnnpSDLNSKSLPLSNSKASSSSlssss 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 197 --------ECGKAFNKSSILTTHKIIRTGEKFYKCKECAKAFNQSSNLTEHKKIHPGEKPYKCEECGKAFNWPStltkHK 268
Cdd:COG5048  115 snsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI----SS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 269 RIHTGEKPYTCEECGKAFNQFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKL 348
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 349 TEHKLTHTGE-------KPYKCEECGKAFNWPSTLTKHNR--IHTGE--KPYKC--EVCGKAFNQFSNLTTHKRIHTAEK 415
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 416 PYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCE---------ECGKAFKWSSKLTEHKITHTGEKP--YKCEECGKAFNH 484
Cdd:COG5048  351 PAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNdkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                        410       420
                 ....*....|....*....|....
gi 375331903 485 FSILTKHKRIHTGEKPYKCEECGK 508
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
387-719 2.76e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 2.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 387 KPYKCEVCGKAFNQFSNLTTHKRIHTAEKPYKC--EECGKAFSRSSNLTKHKKIHIEKKPYKCE-ECGKAFKWSSKLTEH 463
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 464 KITHTGEKPYKCEECGKAFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFykceeCGKAFTQSSN 543
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL-----SKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 544 LTTHKKIHTGGKPYKCEECGKA------------FNQFSTLTKHKIIHTEEKPYKCE---------------ECGKAFKW 596
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 597 SSTLTKHKIIHTGE-------KPYKCEECGKAFKLSSTLSTHK--IIHTGE--KPYKC--EKCGKAFNRSSNLIEHKKIH 663
Cdd:COG5048  267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 375331903 664 TGEQPYKCEEC------GKAFNYSSHLNTHKRIHTKEQPYKC---KECGKAFNQYSNLTTHNKIH 719
Cdd:COG5048  347 TSISPAKEKLLnssskfSPLLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITH 411
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 331-408 9.02e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 9.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 331 KPYKCE--ECGKAFKWSSKLTEHKLtHTGEKPYKCEEcgkafnwPSTLtKHNRIHTGEKPYKCEVCGKAFNQFSNLTTHK 408
Cdd:COG5189  348 KPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHEN-------PSPE-KMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 525-604 1.60e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 525 GEKFYKCE--ECGKAFTQSSNLTTHKKiHTggkpykceECGKAFNQFSTLTKHKIIHTEEKPYKCEECGKAFKWSSTLTK 602
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 375331903 603 HK 604
Cdd:COG5189  417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
444-724 2.75e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 444 PYKCEECGKAFKWSSKLTEHKITHTGEKPYKC--EECGKAFNHFSILTKHKRIHTGEKPYKCE-ECGKAFTQSSNLTTHK 520
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 521 KIHTGEKFYKCEECGKAFTQSSNLTTHKKIHTGGKPYKCEECGKAFNQFSTLTKHKIIHTeekpyKCEECGKAFKWSSTL 600
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLP-----ANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 601 TKHKIIHTGEKPYKCEECGKAFKLSSTLSTHKIIHTgEKPYKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKAFNY 680
Cdd:COG5048  188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 375331903 681 SSHLNTHKRIHT-------KEQPYKCKECGKAFNQYSNLTTHN--KIHTGEKL 724
Cdd:COG5048  267 TASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGESL 319
zf-H2C2_2 pfam13465
Zinc-finger double domain;
488-512 9.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.65e-04
                          10        20
                  ....*....|....*....|....*
gi 375331903  488 LTKHKRIHTGEKPYKCEECGKAFTQ 512
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 553-632 9.86e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 9.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 553 GGKPYKCE--ECGKAFNQFSTLTKHKIiHTEEKPYKCEecgkafkwSSTLTKHKIIHTGEKPYKCEECGKAFKLSSTLST 630
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 375331903 631 HK 632
Cdd:COG5189  417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
668-729 1.65e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.65e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 375331903 668 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKC--KECGKAFNQYSNLTTHNKIHTGEKLYKPED 729
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 581-661 1.67e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 581 EEKPYKCE--ECGKAFKWSSTLTKHKiihtgekpyKCEECGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRSSNLIE 658
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 375331903 659 HKK 661
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-288 2.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.18e-03
                          10        20
                  ....*....|....*....|....*
gi 375331903  264 LTKHKRIHTGEKPYTCEECGKAFNQ 288
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
403-428 2.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.55e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331903  403 NLTTHKRIHTAEKPYKCEECGKAFSR 428
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
683-708 3.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.26e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331903  683 HLNTHKRIHTKEQPYKCKECGKAFNQ 708
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 273-356 3.67e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331903 273 GEKPYTCE--ECGKAFNQFSNLTTHKrihtaekfyKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTE 350
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 375331903 351 HKlTHT 356
Cdd:COG5189  417 HR-KHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
543-568 3.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331903  543 NLTTHKKIHTGGKPYKCEECGKAFNQ 568
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
460-484 3.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.82e-03
                          10        20
                  ....*....|....*....|....*
gi 375331903  460 LTEHKITHTGEKPYKCEECGKAFNH 484
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-343 4.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.01e-03
                          10        20
                  ....*....|....*....|....*
gi 375331903  319 NLTKHKKIHTEKKPYKCEECGKAFK 343
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-400 4.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.01e-03
                          10        20
                  ....*....|....*....|....*
gi 375331903  376 LTKHNRIHTGEKPYKCEVCGKAFNQ 400
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
655-680 4.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331903  655 NLIEHKKIHTGEQPYKCEECGKAFNY 680
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
235-259 4.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.42e-03
                          10        20
                  ....*....|....*....|....*
gi 375331903  235 NLTEHKKIHPGEKPYKCEECGKAFN 259
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-540 4.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.65e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331903  515 NLTTHKKIHTGEKFYKCEECGKAFTQ 540
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
600-623 5.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.18e-03
                          10        20
                  ....*....|....*....|....
gi 375331903  600 LTKHKIIHTGEKPYKCEECGKAFK 623
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
628-652 7.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.67e-03
                          10        20
                  ....*....|....*....|....*
gi 375331903  628 LSTHKIIHTGEKPYKCEKCGKAFNR 652
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
348-371 8.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.63e-03
                          10        20
                  ....*....|....*....|....
gi 375331903  348 LTEHKLTHTGEKPYKCEECGKAFN 371
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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