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Conserved domains on  [gi|375065830|ref|NP_001243474|]
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multiple epidermal growth factor-like domains protein 10 isoform a precursor [Homo sapiens]

Protein Classification

EMI and EGF_Lam domain-containing protein( domain architecture ID 12347790)

protein containing domains EMI, EGF_Lam, and EGF_CA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 31-100 8.85e-11

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


:

Pssm-ID: 462204  Cd Length: 69  Bit Score: 58.59  E-value: 8.85e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 375065830    31 PNVCS--HWESYSVTVQESYPHPFDQIYYTSCTDIlnwFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYE 100
Cdd:pfam07546    1 RNVCAykVVSCVVVTGTESYVQPVYKPYLTWCAGH---RRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
281-318 3.39e-03

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.52  E-value: 3.39e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 375065830    281 CQCHNGGT----CDAATGQCHCSPGYTGERCqDECPVGTYGV 318
Cdd:smart00180    1 CDCDPGGSasgtCDPDTGQCECKPNVTGRRC-DRCAPGYYGD 41
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 542-587 8.70e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam00053:

Pssm-ID: 473889  Cd Length: 49  Bit Score: 35.41  E-value: 8.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 375065830   542 CDC----SHADGCHPTTGHCRCLPGWSGVHCDsVCAEGRWGPNCSLPCYC 587
Cdd:pfam00053    1 CDCnphgSLSDTCDPETGQCLCKPGVTGRHCD-RCKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 31-100 8.85e-11

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 58.59  E-value: 8.85e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 375065830    31 PNVCS--HWESYSVTVQESYPHPFDQIYYTSCTDIlnwFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYE 100
Cdd:pfam07546    1 RNVCAykVVSCVVVTGTESYVQPVYKPYLTWCAGH---RRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
281-318 3.39e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.52  E-value: 3.39e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 375065830    281 CQCHNGGT----CDAATGQCHCSPGYTGERCqDECPVGTYGV 318
Cdd:smart00180    1 CDCDPGGSasgtCDPDTGQCECKPNVTGRRC-DRCAPGYYGD 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 281-326 5.06e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.18  E-value: 5.06e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 375065830   281 CQCHNGGT----CDAATGQCHCSPGYTGERCqDECPVGTYGVLCAETCQC 326
Cdd:pfam00053    1 CDCNPHGSlsdtCDPETGQCLCKPGVTGRHC-DRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 281-317 5.23e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.18  E-value: 5.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 375065830  281 CQCHNGGT----CDAATGQCHCSPGYTGERCqDECPVGTYG 317
Cdd:cd00055     2 CDCNGHGSlsgqCDPGTGQCECKPNTTGRRC-DRCAPGYYG 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 542-587 8.70e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.41  E-value: 8.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 375065830   542 CDC----SHADGCHPTTGHCRCLPGWSGVHCDsVCAEGRWGPNCSLPCYC 587
Cdd:pfam00053    1 CDCnphgSLSDTCDPETGQCLCKPGVTGRHCD-RCKPGYYGLPSDPPQGC 49
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 31-100 8.85e-11

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 58.59  E-value: 8.85e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 375065830    31 PNVCS--HWESYSVTVQESYPHPFDQIYYTSCTDIlnwFKCTRHRVSYRTAYRHGEKTMYRRKSQCCPGFYE 100
Cdd:pfam07546    1 RNVCAykVVSCVVVTGTESYVQPVYKPYLTWCAGH---RRCSTYRTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
281-318 3.39e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.52  E-value: 3.39e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 375065830    281 CQCHNGGT----CDAATGQCHCSPGYTGERCqDECPVGTYGV 318
Cdd:smart00180    1 CDCDPGGSasgtCDPDTGQCECKPNVTGRRC-DRCAPGYYGD 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 281-326 5.06e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.18  E-value: 5.06e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 375065830   281 CQCHNGGT----CDAATGQCHCSPGYTGERCqDECPVGTYGVLCAETCQC 326
Cdd:pfam00053    1 CDCNPHGSlsdtCDPETGQCLCKPGVTGRHC-DRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 281-317 5.23e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.18  E-value: 5.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 375065830  281 CQCHNGGT----CDAATGQCHCSPGYTGERCqDECPVGTYG 317
Cdd:cd00055     2 CDCNGHGSlsgqCDPGTGQCECKPNTTGRRC-DRCAPGYYG 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 542-587 8.70e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 35.41  E-value: 8.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 375065830   542 CDC----SHADGCHPTTGHCRCLPGWSGVHCDsVCAEGRWGPNCSLPCYC 587
Cdd:pfam00053    1 CDCnphgSLSDTCDPETGQCLCKPGVTGRHCD-RCKPGYYGLPSDPPQGC 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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