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Conserved domains on  [gi|357933654|ref|NP_001239557|]
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cadherin-16 isoform 3 precursor [Mus musculus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10638917)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 344-447 7.23e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 7.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 344 TVNIPELSPPGTEIARLSAEDLDAPgsPNSHIVYQLLSpepeeGAENKAFELDPTSGSVTLgTAPL--HAGQSILLQVLA 421
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITT-AKPLdrEEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*.
gi 357933654 422 VDlaGSESGLSSTCEVTVMVTDVNNH 447
Cdd:cd11304   75 TD--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 459-560 2.45e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 459 VTLPEDVKPGALVATLMATDADLEPAFRLMdFAIEEGDPEGIFDLswepDSDHVQLRLRKNLSYEAAPDHKVVVVVSNie 538
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD-- 76

                         90       100
                 ....*....|....*....|..
gi 357933654 539 elvGPGPGPAATATVTILVERV 560
Cdd:cd11304   77 ---GGGPPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-334 1.21e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.03  E-value: 1.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 246 VHLAENLKVvyPHSIAQVHWSGGD------VHYQLESQPP-GPFDVD-TEGMLHVTMELDREAQAEYQLQVRAQNSHGED 317
Cdd:cd11304    4 VSVPENAPP--GTVVLTVSATDPDsgengeVTYSIVSGNEdGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 357933654 318 YAEPLELQVVVMDENDN 334
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 132-236 1.43e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.95  E-value: 1.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 132 IYRAQLSQGTRPGVPFLFLEASDGDAPgtANSDLRFHILSQSPPqplpDMFQLDPHLGALALSpsgsTSLDHALEETYQL 211
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNED----GLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                         90       100
                 ....*....|....*....|....*
gi 357933654 212 LVQVKDMGDQPsgHQAIATVEISIV 236
Cdd:cd11304   71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-657 1.61e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.95  E-value: 1.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 570 SYETSIPVSTPAGSLLLTIQPSDP---MSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQGAQPgDTYTVLVEAQDTDK 645
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                         90
                 ....*....|..
gi 357933654 646 PGLSTSATVVIH 657
Cdd:cd11304   80 PPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 67-126 7.06e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 7.06e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654    67 DQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHVKDENDQVP 126
Cdd:smart00112  22 DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 344-447 7.23e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 7.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 344 TVNIPELSPPGTEIARLSAEDLDAPgsPNSHIVYQLLSpepeeGAENKAFELDPTSGSVTLgTAPL--HAGQSILLQVLA 421
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITT-AKPLdrEEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*.
gi 357933654 422 VDlaGSESGLSSTCEVTVMVTDVNNH 447
Cdd:cd11304   75 TD--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 459-560 2.45e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 459 VTLPEDVKPGALVATLMATDADLEPAFRLMdFAIEEGDPEGIFDLswepDSDHVQLRLRKNLSYEAAPDHKVVVVVSNie 538
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD-- 76

                         90       100
                 ....*....|....*....|..
gi 357933654 539 elvGPGPGPAATATVTILVERV 560
Cdd:cd11304   77 ---GGGPPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-334 1.21e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.03  E-value: 1.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 246 VHLAENLKVvyPHSIAQVHWSGGD------VHYQLESQPP-GPFDVD-TEGMLHVTMELDREAQAEYQLQVRAQNSHGED 317
Cdd:cd11304    4 VSVPENAPP--GTVVLTVSATDPDsgengeVTYSIVSGNEdGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 357933654 318 YAEPLELQVVVMDENDN 334
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 266-336 1.43e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 1.43e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357933654   266 SGGDVHYQLESQPP-GPFDVDTE-GMLHVTMELDREAQAEYQLQVRAQNSHGEDYAEPLELQVVVMDENDNAP 336
Cdd:smart00112   9 ENGKVTYSILSGNDdGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 132-236 1.43e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.95  E-value: 1.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 132 IYRAQLSQGTRPGVPFLFLEASDGDAPgtANSDLRFHILSQSPPqplpDMFQLDPHLGALALSpsgsTSLDHALEETYQL 211
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNED----GLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                         90       100
                 ....*....|....*....|....*
gi 357933654 212 LVQVKDMGDQPsgHQAIATVEISIV 236
Cdd:cd11304   71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-657 1.61e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.95  E-value: 1.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 570 SYETSIPVSTPAGSLLLTIQPSDP---MSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQGAQPgDTYTVLVEAQDTDK 645
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                         90
                 ....*....|..
gi 357933654 646 PGLSTSATVVIH 657
Cdd:cd11304   80 PPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 361-449 3.30e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 3.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654   361 SAEDLDAPgsPNSHIVYQLLSpepeeGAENKAFELDPTSGSVTLgTAPL--HAGQSILLQVLAVDlaGSESGLSSTCEVT 438
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 357933654   439 VMVTDVNNHAP 449
Cdd:smart00112  71 ITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 67-126 7.06e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 7.06e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654    67 DQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHVKDENDQVP 126
Cdd:smart00112  22 DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 67-123 4.20e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.10  E-value: 4.20e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 357933654  67 DQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHVKDEND 123
Cdd:cd11304   41 EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
343-442 5.28e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 5.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654  343 PTVNIPELSPPGTEIARLSAEDLDAPgsPNSHIVYQLLSPEPeegaeNKAFELDPTSGSVTLgTAPL--HAGQSILLQVL 420
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDIST-TKPLdrESIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 357933654  421 AVDLAGseSGLSSTCEVTVMVT 442
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
458-558 5.70e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 5.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654  458 PVTLPEDVKPGALVATLMATDADLEPAFRLMdFAIEEGDPEGIFDLswepDSDHVQLRLRKNLSYEAAPDHKVVVVVSNi 537
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATD- 75

                          90       100
                  ....*....|....*....|.
gi 357933654  538 eelvGPGPGPAATATVTILVE 558
Cdd:pfam00028  76 ----SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 152-236 1.79e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654   152 ASDGDAPgtANSDLRFHILSQSPPqplpDMFQLDPHLGALALSpsgsTSLDHALEETYQLLVQVKDMGDQPsgHQAIATV 231
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTT----KPLDREEQPEYTLTVEATDGGGPP--LSSTATV 69


                   ....*
gi 357933654   232 EISIV 236
Cdd:smart00112  70 TITVL 74
Cadherin pfam00028
Cadherin domain;
571-657 2.25e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.22  E-value: 2.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654  571 YETSIPVSTPAGSLLLTIQ---PSDPMSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQGAQPGdTYTVLVEAQDTDKP 646
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTatdPDLGPNGRIFYSILGGGPgGNFRIDPDTGDISTTKPLDRESIG-EYELTVEATDSGGP 79

                          90
                  ....*....|.
gi 357933654  647 GLSTSATVVIH 657
Cdd:pfam00028  80 PLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
245-328 6.20e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 6.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654  245 PVHLAENLKV-VYPHSIAQVHWSGGD---VHYQLESQPPGP-FDVDTE-GMLHVTMELDREAQAEYQLQVRAQNSHGEDY 318
Cdd:pfam00028   2 SASVPENAPVgTEVLTVTATDPDLGPngrIFYSILGGGPGGnFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 357933654  319 AEPLELQVVV 328
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
69-118 1.07e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 1.07e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 357933654   69 NTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHV 118
Cdd:pfam00028  42 GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 590-657 1.27e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.88  E-value: 1.27e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 357933654   590 PSDPMSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQgAQPGDTYTVLVEAQDTDKPGLSTSATVVIH 657
Cdd:smart00112   5 ADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLD-REEQPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
133-235 2.79e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 2.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654  133 YRAQLSQGTRPGVPFLFLEASDGDAPgtANSDLRFHILSQSPPQplpdMFQLDPHLGALALSpsgsTSLDHALEETYQLL 212
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG----NFRIDPDTGDISTT----KPLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|...
gi 357933654  213 VQVKDMGDQPSghQAIATVEISI 235
Cdd:pfam00028  71 VEATDSGGPPL--SSTATVTITV 91
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 344-447 7.23e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 7.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 344 TVNIPELSPPGTEIARLSAEDLDAPgsPNSHIVYQLLSpepeeGAENKAFELDPTSGSVTLgTAPL--HAGQSILLQVLA 421
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITT-AKPLdrEEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*.
gi 357933654 422 VDlaGSESGLSSTCEVTVMVTDVNNH 447
Cdd:cd11304   75 TD--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 459-560 2.45e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 459 VTLPEDVKPGALVATLMATDADLEPAFRLMdFAIEEGDPEGIFDLswepDSDHVQLRLRKNLSYEAAPDHKVVVVVSNie 538
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD-- 76

                         90       100
                 ....*....|....*....|..
gi 357933654 539 elvGPGPGPAATATVTILVERV 560
Cdd:cd11304   77 ---GGGPPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-334 1.21e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.03  E-value: 1.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 246 VHLAENLKVvyPHSIAQVHWSGGD------VHYQLESQPP-GPFDVD-TEGMLHVTMELDREAQAEYQLQVRAQNSHGED 317
Cdd:cd11304    4 VSVPENAPP--GTVVLTVSATDPDsgengeVTYSIVSGNEdGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 357933654 318 YAEPLELQVVVMDENDN 334
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 266-336 1.43e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 1.43e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 357933654   266 SGGDVHYQLESQPP-GPFDVDTE-GMLHVTMELDREAQAEYQLQVRAQNSHGEDYAEPLELQVVVMDENDNAP 336
Cdd:smart00112   9 ENGKVTYSILSGNDdGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 132-236 1.43e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.95  E-value: 1.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 132 IYRAQLSQGTRPGVPFLFLEASDGDAPgtANSDLRFHILSQSPPqplpDMFQLDPHLGALALSpsgsTSLDHALEETYQL 211
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNED----GLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                         90       100
                 ....*....|....*....|....*
gi 357933654 212 LVQVKDMGDQPsgHQAIATVEISIV 236
Cdd:cd11304   71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-657 1.61e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.95  E-value: 1.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 570 SYETSIPVSTPAGSLLLTIQPSDP---MSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQGAQPgDTYTVLVEAQDTDK 645
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                         90
                 ....*....|..
gi 357933654 646 PGLSTSATVVIH 657
Cdd:cd11304   80 PPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 361-449 3.30e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 3.30e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654   361 SAEDLDAPgsPNSHIVYQLLSpepeeGAENKAFELDPTSGSVTLgTAPL--HAGQSILLQVLAVDlaGSESGLSSTCEVT 438
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 357933654   439 VMVTDVNNHAP 449
Cdd:smart00112  71 ITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 67-126 7.06e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 7.06e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654    67 DQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHVKDENDQVP 126
Cdd:smart00112  22 DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 67-123 4.20e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 63.10  E-value: 4.20e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 357933654  67 DQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHVKDEND 123
Cdd:cd11304   41 EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
343-442 5.28e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 5.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654  343 PTVNIPELSPPGTEIARLSAEDLDAPgsPNSHIVYQLLSPEPeegaeNKAFELDPTSGSVTLgTAPL--HAGQSILLQVL 420
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDIST-TKPLdrESIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 357933654  421 AVDLAGseSGLSSTCEVTVMVT 442
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
458-558 5.70e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 5.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654  458 PVTLPEDVKPGALVATLMATDADLEPAFRLMdFAIEEGDPEGIFDLswepDSDHVQLRLRKNLSYEAAPDHKVVVVVSNi 537
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATD- 75

                          90       100
                  ....*....|....*....|.
gi 357933654  538 eelvGPGPGPAATATVTILVE 558
Cdd:pfam00028  76 ----SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 152-236 1.79e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654   152 ASDGDAPgtANSDLRFHILSQSPPqplpDMFQLDPHLGALALSpsgsTSLDHALEETYQLLVQVKDMGDQPsgHQAIATV 231
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTT----KPLDREEQPEYTLTVEATDGGGPP--LSSTATV 69


                   ....*
gi 357933654   232 EISIV 236
Cdd:smart00112  70 TITVL 74
Cadherin pfam00028
Cadherin domain;
571-657 2.25e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.22  E-value: 2.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654  571 YETSIPVSTPAGSLLLTIQ---PSDPMSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQGAQPGdTYTVLVEAQDTDKP 646
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTatdPDLGPNGRIFYSILGGGPgGNFRIDPDTGDISTTKPLDRESIG-EYELTVEATDSGGP 79

                          90
                  ....*....|.
gi 357933654  647 GLSTSATVVIH 657
Cdd:pfam00028  80 PLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
245-328 6.20e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 6.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654  245 PVHLAENLKV-VYPHSIAQVHWSGGD---VHYQLESQPPGP-FDVDTE-GMLHVTMELDREAQAEYQLQVRAQNSHGEDY 318
Cdd:pfam00028   2 SASVPENAPVgTEVLTVTATDPDLGPngrIFYSILGGGPGGnFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 357933654  319 AEPLELQVVV 328
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
69-118 1.07e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 1.07e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 357933654   69 NTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILWGPQLVTVHV 118
Cdd:pfam00028  42 GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 230-334 1.19e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 44.64  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654 230 TVEISIVENSWAPLEPVHLAENLkVVYPHSIAQVHWSGGDvhyqlesQPPGPFDVDTE-GMLHVTMELDREAQAEYQLQV 308
Cdd:cd00031    1 IPDGSAVEGRSRGSFRVSIPTDL-IASSGEIIKISAAGKE-------ALPSWLHWEPHsGILEGLEKLDREDKGVHYISV 72

                         90       100
                 ....*....|....*....|....*.
gi 357933654 309 RAQNSHGEDYAEPLELQVVVMDENDN 334
Cdd:cd00031   73 SAASLGANVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 590-657 1.27e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 43.88  E-value: 1.27e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 357933654   590 PSDPMSRTLRFSLVNDSE-GWLCIKEVSGEVHTAQSLQgAQPGDTYTVLVEAQDTDKPGLSTSATVVIH 657
Cdd:smart00112   5 ADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLD-REEQPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
133-235 2.79e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 2.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654  133 YRAQLSQGTRPGVPFLFLEASDGDAPgtANSDLRFHILSQSPPQplpdMFQLDPHLGALALSpsgsTSLDHALEETYQLL 212
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG----NFRIDPDTGDISTT----KPLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|...
gi 357933654  213 VQVKDMGDQPSghQAIATVEISI 235
Cdd:pfam00028  71 VEATDSGGPPL--SSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 31-123 9.02e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 42.33  E-value: 9.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357933654  31 VPENYGGnfPFYILKLPLPLGRDEGHIV-LSGDSNTADQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLESEDGRILW 109
Cdd:cd00031    6 AVEGRSR--GSFRVSIPTDLIASSGEIIkISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQ 83

                         90
                 ....*....|....
gi 357933654 110 GPQLVTVHVKDEND 123
Cdd:cd00031   84 TSSVFSIEVYDEND 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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