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Conserved domains on  [gi|357588496|ref|NP_001239520|]
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small muscular protein [Mus musculus]

Protein Classification

Chisel domain-containing protein( domain architecture ID 10634029)

Chisel domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chisel pfam15355
Stretch-responsive small skeletal muscle X protein, Chisel; The murine X-linked gene Chisel ...
 1-84 1.53e-38

Stretch-responsive small skeletal muscle X protein, Chisel; The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localizes to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.


:

Pssm-ID: 405939  Cd Length: 86  Bit Score: 123.10  E-value: 1.53e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588496   1 MSKQPISNVRAIQANINIPMGAFRPGAGQPPRRKESTPETEEGAPTTS--EEKKPIPGMKKFPGPVVNLSEIQNVKSELK 78
Cdd:pfam15355  1 MSKQPASNVRAIQANINIPMGAFRPGAGHPPKRKECTVEPEESVPASEtpEEKKPLPGAVKLPGPAVNLSEIQNVKSELK 80


                 ....*.
gi 357588496  79 FVPKGE 84
Cdd:pfam15355 81 FVPKAE 86
 
Name Accession Description Interval E-value
Chisel pfam15355
Stretch-responsive small skeletal muscle X protein, Chisel; The murine X-linked gene Chisel ...
 1-84 1.53e-38

Stretch-responsive small skeletal muscle X protein, Chisel; The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localizes to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.


Pssm-ID: 405939  Cd Length: 86  Bit Score: 123.10  E-value: 1.53e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588496   1 MSKQPISNVRAIQANINIPMGAFRPGAGQPPRRKESTPETEEGAPTTS--EEKKPIPGMKKFPGPVVNLSEIQNVKSELK 78
Cdd:pfam15355  1 MSKQPASNVRAIQANINIPMGAFRPGAGHPPKRKECTVEPEESVPASEtpEEKKPLPGAVKLPGPAVNLSEIQNVKSELK 80


                 ....*.
gi 357588496  79 FVPKGE 84
Cdd:pfam15355 81 FVPKAE 86
 
Name Accession Description Interval E-value
Chisel pfam15355
Stretch-responsive small skeletal muscle X protein, Chisel; The murine X-linked gene Chisel ...
 1-84 1.53e-38

Stretch-responsive small skeletal muscle X protein, Chisel; The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localizes to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.


Pssm-ID: 405939  Cd Length: 86  Bit Score: 123.10  E-value: 1.53e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357588496   1 MSKQPISNVRAIQANINIPMGAFRPGAGQPPRRKESTPETEEGAPTTS--EEKKPIPGMKKFPGPVVNLSEIQNVKSELK 78
Cdd:pfam15355  1 MSKQPASNVRAIQANINIPMGAFRPGAGHPPKRKECTVEPEESVPASEtpEEKKPLPGAVKLPGPAVNLSEIQNVKSELK 80


                 ....*.
gi 357588496  79 FVPKGE 84
Cdd:pfam15355 81 FVPKAE 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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