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Conserved domains on  [gi|354983489|ref|NP_001239001|]
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heparan sulfate glucosamine 3-O-sulfotransferase 4 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
190-427 4.26e-46

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 160.20  E-value: 4.26e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354983489  190 LPQALIIGVKKGGTRALLEAIRVHPDVRAVGV--EPHFFD-RNYEKGLEWYrnvmpktldgqitmeKTPSYFVTNEAPKR 266
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNnHNRSPFLEWY---------------PGDTYFDVAEGPVR 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354983489  267 IHSMA--------------------KDIKLIVVVRNPVTRAISDYTQT----LSKKPEIPTFEVLAFknrtlglidaSWS 322
Cdd:pfam00685  66 LNALPspriikthlplhllpkslwdPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDF----------LNG 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354983489  323 AIRIGIYALHLENWLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTE-----KHFYFNKTKGFPCLKK---PE 394
Cdd:pfam00685 136 KVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEEldkivKHLSFENMKGNPCLNYsklPK 215

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 354983489  395 DSSA--PRCLGKSKgrtHPRIDPDVIHRLRKFYKP 427
Cdd:pfam00685 216 EVSPffRKGLVGDW---KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
190-427 4.26e-46

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 160.20  E-value: 4.26e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354983489  190 LPQALIIGVKKGGTRALLEAIRVHPDVRAVGV--EPHFFD-RNYEKGLEWYrnvmpktldgqitmeKTPSYFVTNEAPKR 266
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNnHNRSPFLEWY---------------PGDTYFDVAEGPVR 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354983489  267 IHSMA--------------------KDIKLIVVVRNPVTRAISDYTQT----LSKKPEIPTFEVLAFknrtlglidaSWS 322
Cdd:pfam00685  66 LNALPspriikthlplhllpkslwdPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDF----------LNG 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354983489  323 AIRIGIYALHLENWLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTE-----KHFYFNKTKGFPCLKK---PE 394
Cdd:pfam00685 136 KVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEEldkivKHLSFENMKGNPCLNYsklPK 215

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 354983489  395 DSSA--PRCLGKSKgrtHPRIDPDVIHRLRKFYKP 427
Cdd:pfam00685 216 EVSPffRKGLVGDW---KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
190-427 4.26e-46

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 160.20  E-value: 4.26e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354983489  190 LPQALIIGVKKGGTRALLEAIRVHPDVRAVGV--EPHFFD-RNYEKGLEWYrnvmpktldgqitmeKTPSYFVTNEAPKR 266
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNnHNRSPFLEWY---------------PGDTYFDVAEGPVR 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354983489  267 IHSMA--------------------KDIKLIVVVRNPVTRAISDYTQT----LSKKPEIPTFEVLAFknrtlglidaSWS 322
Cdd:pfam00685  66 LNALPspriikthlplhllpkslwdPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDF----------LNG 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354983489  323 AIRIGIYALHLENWLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTE-----KHFYFNKTKGFPCLKK---PE 394
Cdd:pfam00685 136 KVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEEldkivKHLSFENMKGNPCLNYsklPK 215

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 354983489  395 DSSA--PRCLGKSKgrtHPRIDPDVIHRLRKFYKP 427
Cdd:pfam00685 216 EVSPffRKGLVGDW---KNYFTPEQAEKFDEIYQE 247
Sulfotransfer_3 pfam13469
Sulfotransferase family;
195-370 7.35e-15

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 72.32  E-value: 7.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354983489  195 IIGVKKGGTRaLLEAI-RVHPDVRAVGVEPHFFDRNYEKGLEW---YRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSm 270
Cdd:pfam13469   3 IVGLPRSGTT-LLHRLlAAHPDVRPPEETWFVIPRILALLQAWgksLEALARVPSYARWLCDKSPSHLFHLDLLLKAFP- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354983489  271 akDIKLIVVVRNPVTRAISDYTQtlskkpeIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHlENWLQYFPlSQILFVSG 350
Cdd:pfam13469  81 --DAKFIHLHRDPVDTVISSYCS-------LFGFTLSSYSTAFLRDIGLALARWSRAYERLM-AARARVPP-GRFLDVRY 149

                         170       180
                  ....*....|....*....|
gi 354983489  351 ERLIVDPAGEMAKVQDFLGL 370
Cdd:pfam13469 150 EDLVADPEGTLRRILEFLGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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