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Conserved domains on  [gi|340007384|ref|NP_001229981|]
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branched-chain-amino-acid aminotransferase, mitochondrial isoform 2 [Mus musculus]

Protein Classification

branched-chain amino acid aminotransferase( domain architecture ID 10107512)

branched-chain amino acid aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 48-343 3.78e-129

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


:

Pssm-ID: 238798  Cd Length: 279  Bit Score: 370.76  E-value: 3.78e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  48 TLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWVPDGNGTS 127
Cdd:cd01557    1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 128 LYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPGdSMTPVSLLADpSFVRAWIGGVGDCKLGGNYGPTVAVQREAQK 207
Cdd:cd01557   81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKG-GEKGVSALVS-SFRRAAPGGPGAAKAGGNYAASLLAQKEAAE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 208 RGCEQVLWLYGPDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRA 287
Cdd:cd01557  159 KGYDQALWLDGAHGYVAEVGTMNIFFVK---DG--ELITPPLDGSILPGITRDSILELARDLG-IKVEERPITRDELYEA 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 340007384 288 LeegrvrEVFGSGTACQVCPVHQILYEGKQlhiPTMENGPELILRFQKELKAIQYG 343
Cdd:cd01557  233 D------EVFATGTAAVVTPVGEIDYRGKE---PGEGEVGPVTKKLYDLLTDIQYG 279
 
Name Accession Description Interval E-value
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 48-343 3.78e-129

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


Pssm-ID: 238798  Cd Length: 279  Bit Score: 370.76  E-value: 3.78e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  48 TLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWVPDGNGTS 127
Cdd:cd01557    1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 128 LYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPGdSMTPVSLLADpSFVRAWIGGVGDCKLGGNYGPTVAVQREAQK 207
Cdd:cd01557   81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKG-GEKGVSALVS-SFRRAAPGGPGAAKAGGNYAASLLAQKEAAE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 208 RGCEQVLWLYGPDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRA 287
Cdd:cd01557  159 KGYDQALWLDGAHGYVAEVGTMNIFFVK---DG--ELITPPLDGSILPGITRDSILELARDLG-IKVEERPITRDELYEA 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 340007384 288 LeegrvrEVFGSGTACQVCPVHQILYEGKQlhiPTMENGPELILRFQKELKAIQYG 343
Cdd:cd01557  233 D------EVFATGTAAVVTPVGEIDYRGKE---PGEGEVGPVTKKLYDLLTDIQYG 279
PRK13357 PRK13357
branched-chain amino acid aminotransferase; Provisional
 1-353 2.36e-126

branched-chain amino acid aminotransferase; Provisional


Pssm-ID: 237363  Cd Length: 356  Bit Score: 366.40  E-value: 2.36e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384   1 MTKEPQKKPAPSQaLLFGKTFTDHMLMVEWNNKAgWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFR 80
Cdd:PRK13357   9 PTSDEKRAIDWAN-LGFGYVFTDHMVVIDYKDGK-WHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDGSIVLFR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  81 PWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWV-PDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVG 159
Cdd:PRK13357  87 PDANAKRLQRSADRLLMPELPEELFLEAVKQLVKADRDWVpPYGEGASLYLRPFMIATEPFLGVKPAEEYIFCVIASPVG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 160 SYFPGDsMTPVSLLADPSFVRAWIGGVGDCKLGGNYGPTVAVQREAQKRGCEQVLWLYGPDHQ-LTEVGTMNIF-VYwth 237
Cdd:PRK13357 167 AYFKGG-VKPVSIWVSDEYDRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEHTyIEEVGGMNFFfIT--- 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 238 EDGVlelVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRALEEGRVREVFGSGTACQVCPVHQILYEGKQ 317
Cdd:PRK13357 243 KDGT---VTPPLSGSILPGITRDSLLQLAEDLG-LTVEERPVSIDEWQADAASGEFTEAFACGTAAVITPIGGIKYKDKE 318

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 340007384 318 LHIPTMENGPeLILRFQKELKAIQYGASA--HDWMFRV 353
Cdd:PRK13357 319 FVIGDGEVGP-VTQKLYDELTGIQFGDVEdpHGWIVKV 355
ilvE_II TIGR01123
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ...
 36-353 2.39e-100

branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 233278  Cd Length: 313  Bit Score: 298.98  E-value: 2.39e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384   36 WGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEV 115
Cdd:TIGR01123   1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  116 DKDWVPD-GNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPGDSmTPVSLLADPSFVRAWIGGVGDCKLGGN 194
Cdd:TIGR01123  81 NKDWVPPyGSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGGL-APVSIFVTTEYDRAAPGGTGAVKVGGN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  195 YGPTVAVQREAQKRGCEQVLWLYGPDHQ-LTEVGTMNIFVYWTheDGvlELVTPPLNGVILPGVVRQSLLDLARTWGeFR 273
Cdd:TIGR01123 160 YAASLLAQAKAAEQGCDQVVYLDPVEHTyIEEVGAMNFFFITG--DG--ELVTPPLSGSILPGITRDSLLQLAKDLG-ME 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  274 VAERKVTMKELKRALEEGrvREVFGSGTACQVCPVHQILYEGKQLHIPTMENGpELILRFQKELKAIQYG--ASAHDWMF 351
Cdd:TIGR01123 235 VEERRIDIDELKAFVEAG--EIVFACGTAAVITPVGEIQHGGKEVVFASGQPG-EVTKALYDELTDIQYGdfEDPYGWIV 311


                  ..
gi 340007384  352 RV 353
Cdd:TIGR01123 312 EV 313
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 36-346 4.70e-72

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 225.45  E-value: 4.70e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  36 WGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIE 114
Cdd:COG0115    4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDG-----RLFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 115 VDKDwvpdgngTSLYVRPVLIGNEPSLGVGMVT-QALLYVILCPVGSYFPGDSMTPVSLLADPsFVRAWIGGVGDCKlGG 193
Cdd:COG0115   79 ANGL-------EDGYIRPQVTRGVGGRGVFAEEyEPTVIIIASPLPAYPAEAYEKGVRVITSP-YRRAAPGGLGGIK-TG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 194 NYGPTVAVQREAQKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDLARTWGeFR 273
Cdd:COG0115  150 NYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIV---KDGVL--VTPPLSGGILPGITRDSVIELARELG-IP 222

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 340007384 274 VAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQIlyEGKQlhIPTMENGPeLILRFQKELKAIQYGASA 346
Cdd:COG0115  223 VEERPISLEELYTA------DEVFLTGTAAEVTPVTEI--DGRP--IGDGKPGP-VTRRLRELYTDIVRGEAE 284
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 61-311 5.84e-35

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 127.47  E-value: 5.84e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384   61 QLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIEVDKDWVPdgngtslYVRPVLIGNEP 139
Cdd:pfam01063   1 GVFETLRVYNG-----KIFFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVG-------RLRLTVSRGPG 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  140 SLGV-GMVTQALLYVILCPVGSYFPGDSMTPVSLLADPSFVRAwiggvgDCKlGGNYGPTVAVQREAQKRGCEQVLwLYG 218
Cdd:pfam01063  69 GFGLpTSDPTLAIFVSALPPPPESKKKGVISSLVRRNPPSPLP------GAK-TLNYLENVLARREAKAQGADDAL-LLD 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  219 PDHQLTEVGTMNIFvyWTHEDgvlELVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFG 298
Cdd:pfam01063 141 EDGNVTEGSTSNVF--LVKGG---TLYTPPLESGILPGITRQALLDLAKALG-LEVEERPITLADLQEA------DEAFL 208

                         250
                  ....*....|...
gi 340007384  299 SGTACQVCPVHQI 311
Cdd:pfam01063 209 TNSLRGVTPVSSI 221
 
Name Accession Description Interval E-value
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 48-343 3.78e-129

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


Pssm-ID: 238798  Cd Length: 279  Bit Score: 370.76  E-value: 3.78e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  48 TLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWVPDGNGTS 127
Cdd:cd01557    1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 128 LYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPGdSMTPVSLLADpSFVRAWIGGVGDCKLGGNYGPTVAVQREAQK 207
Cdd:cd01557   81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKG-GEKGVSALVS-SFRRAAPGGPGAAKAGGNYAASLLAQKEAAE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 208 RGCEQVLWLYGPDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRA 287
Cdd:cd01557  159 KGYDQALWLDGAHGYVAEVGTMNIFFVK---DG--ELITPPLDGSILPGITRDSILELARDLG-IKVEERPITRDELYEA 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 340007384 288 LeegrvrEVFGSGTACQVCPVHQILYEGKQlhiPTMENGPELILRFQKELKAIQYG 343
Cdd:cd01557  233 D------EVFATGTAAVVTPVGEIDYRGKE---PGEGEVGPVTKKLYDLLTDIQYG 279
PRK13357 PRK13357
branched-chain amino acid aminotransferase; Provisional
 1-353 2.36e-126

branched-chain amino acid aminotransferase; Provisional


Pssm-ID: 237363  Cd Length: 356  Bit Score: 366.40  E-value: 2.36e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384   1 MTKEPQKKPAPSQaLLFGKTFTDHMLMVEWNNKAgWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFR 80
Cdd:PRK13357   9 PTSDEKRAIDWAN-LGFGYVFTDHMVVIDYKDGK-WHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDGSIVLFR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  81 PWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWV-PDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVG 159
Cdd:PRK13357  87 PDANAKRLQRSADRLLMPELPEELFLEAVKQLVKADRDWVpPYGEGASLYLRPFMIATEPFLGVKPAEEYIFCVIASPVG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 160 SYFPGDsMTPVSLLADPSFVRAWIGGVGDCKLGGNYGPTVAVQREAQKRGCEQVLWLYGPDHQ-LTEVGTMNIF-VYwth 237
Cdd:PRK13357 167 AYFKGG-VKPVSIWVSDEYDRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEHTyIEEVGGMNFFfIT--- 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 238 EDGVlelVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRALEEGRVREVFGSGTACQVCPVHQILYEGKQ 317
Cdd:PRK13357 243 KDGT---VTPPLSGSILPGITRDSLLQLAEDLG-LTVEERPVSIDEWQADAASGEFTEAFACGTAAVITPIGGIKYKDKE 318

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 340007384 318 LHIPTMENGPeLILRFQKELKAIQYGASA--HDWMFRV 353
Cdd:PRK13357 319 FVIGDGEVGP-VTQKLYDELTGIQFGDVEdpHGWIVKV 355
ilvE_II TIGR01123
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ...
 36-353 2.39e-100

branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 233278  Cd Length: 313  Bit Score: 298.98  E-value: 2.39e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384   36 WGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEV 115
Cdd:TIGR01123   1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  116 DKDWVPD-GNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPGDSmTPVSLLADPSFVRAWIGGVGDCKLGGN 194
Cdd:TIGR01123  81 NKDWVPPyGSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGGL-APVSIFVTTEYDRAAPGGTGAVKVGGN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  195 YGPTVAVQREAQKRGCEQVLWLYGPDHQ-LTEVGTMNIFVYWTheDGvlELVTPPLNGVILPGVVRQSLLDLARTWGeFR 273
Cdd:TIGR01123 160 YAASLLAQAKAAEQGCDQVVYLDPVEHTyIEEVGAMNFFFITG--DG--ELVTPPLSGSILPGITRDSLLQLAKDLG-ME 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  274 VAERKVTMKELKRALEEGrvREVFGSGTACQVCPVHQILYEGKQLHIPTMENGpELILRFQKELKAIQYG--ASAHDWMF 351
Cdd:TIGR01123 235 VEERRIDIDELKAFVEAG--EIVFACGTAAVITPVGEIQHGGKEVVFASGQPG-EVTKALYDELTDIQYGdfEDPYGWIV 311


                  ..
gi 340007384  352 RV 353
Cdd:TIGR01123 312 EV 313
PLPDE_IV cd00449
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
 54-337 1.65e-80

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


Pssm-ID: 238254 [Multi-domain]  Cd Length: 256  Bit Score: 245.97  E-value: 1.65e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  54 SGLHYSLQLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIEVdkdwvpdGNGTSLYVRP 132
Cdd:cd00449    2 RGLHYGDGVFEGLRAGKG-----RLFRLDEHLDRLNRSAKRLGLPiPYDREELREALKELVAA-------NNGASLYIRP 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 133 VLIGNEPSLGVGM--VTQALLYVILCPVGSYFPGdSMTPVSLLADPSFVRAWIGGVGDCKLGGNYgPTVAVQREAQKRGC 210
Cdd:cd00449   70 LLTRGVGGLGVAPppSPEPTFVVFASPVGAYAKG-GEKGVRLITSPDRRRAAPGGTGDAKTGGNL-NSVLAKQEAAEAGA 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 211 EQVLWLYGpDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAlee 290
Cdd:cd00449  148 DEALLLDD-NGYVTEGSASNVFIVK---DG--ELVTPPLDGGILPGITRDSVIELAKELG-IKVEERPISLDELYAA--- 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 340007384 291 grvREVFGSGTACQVCPVHQILYEGKqlhipTMENGPELILRFQKEL 337
Cdd:cd00449  218 ---DEVFLTGTAAEVTPVTEIDGRGI-----GDGKPGPVTRKLRELL 256
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 36-346 4.70e-72

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 225.45  E-value: 4.70e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  36 WGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIE 114
Cdd:COG0115    4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDG-----RLFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 115 VDKDwvpdgngTSLYVRPVLIGNEPSLGVGMVT-QALLYVILCPVGSYFPGDSMTPVSLLADPsFVRAWIGGVGDCKlGG 193
Cdd:COG0115   79 ANGL-------EDGYIRPQVTRGVGGRGVFAEEyEPTVIIIASPLPAYPAEAYEKGVRVITSP-YRRAAPGGLGGIK-TG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 194 NYGPTVAVQREAQKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDLARTWGeFR 273
Cdd:COG0115  150 NYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIV---KDGVL--VTPPLSGGILPGITRDSVIELARELG-IP 222

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 340007384 274 VAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQIlyEGKQlhIPTMENGPeLILRFQKELKAIQYGASA 346
Cdd:COG0115  223 VEERPISLEELYTA------DEVFLTGTAAEVTPVTEI--DGRP--IGDGKPGP-VTRRLRELYTDIVRGEAE 284
PLN02782 PLN02782
Branched-chain amino acid aminotransferase
 17-318 1.36e-60

Branched-chain amino acid aminotransferase


Pssm-ID: 215418  Cd Length: 403  Bit Score: 199.69  E-value: 1.36e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  17 FGKTFTDHMLMVEWNNKAGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARRLC 96
Cdd:PLN02782  77 FGLVPTDYMYIMKCNRDGEFSKGELQRFGNIELSPSAGVLNYGQGLFEGLKAYRKEDGNILLFRPEENAIRMRNGAERMC 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  97 LPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPgDSMTPVSLLADP 176
Cdd:PLN02782 157 MPAPTVEQFVEAVKETVLANKRWVPPPGKGSLYIRPLLMGSGAVLGLAPAPEYTFLIYVSPVGNYFK-EGVAPINLIVEN 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 177 SFVRAWIGGVGDCKLGGNYGPTVAVQREAQKRGCEQVLWLygpD--HQ--LTEVGTMNIFVYwthEDGVLElvTPPLNGV 252
Cdd:PLN02782 236 EFHRATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYL---DcvHKkyLEEVSSCNIFIV---KDNVIS--TPAIKGT 307

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 340007384 253 ILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQILYEGKQL 318
Cdd:PLN02782 308 ILPGITRKSIIDVARSQG-FQVEERNVTVDELLEA------DEVFCTGTAVVVSPVGSITYKGKRV 366
PLN03117 PLN03117
Branched-chain-amino-acid aminotransferase; Provisional
 15-353 1.61e-53

Branched-chain-amino-acid aminotransferase; Provisional


Pssm-ID: 178664  Cd Length: 355  Bit Score: 180.13  E-value: 1.61e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  15 LLFGKTFTDHMLMVEWNNKAGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARR 94
Cdd:PLN03117  25 LGFALVPTDYMYVAKCKQGESFSEGKIVPYGDISISPCAGILNYGQGLFEGLKAYRTEDGRITLFRPDQNALRMQTGADR 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  95 LCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPGDSmtPVSLLA 174
Cdd:PLN03117 105 LCMTPPSLEQFVEAVKQTVLANKKWVPPPGKGTLYIRPLLIGSGAVLGVAPAPEYTFLIYASPVGNYHKASS--GLNLKV 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 175 DPSFVRAWIGGVGDCKLGGNYGPTVAVQREAQKRGCEQVLWL-YGPDHQLTEVGTMNIFVYwthEDGVLElvTPPLNGVI 253
Cdd:PLN03117 183 DHKHRRAHSGGTGGVKSCTNYSPVVKSLIEAKSSGFSDVLFLdAATGKNIEELSACNIFIL---KGNIVS--TPPTSGTI 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 254 LPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQILYEGKQLHIPTMENGpeLILRF 333
Cdd:PLN03117 258 LPGVTRKSISELARDIG-YQVEERDVSVDELLEA------EEVFCTGTAVVVKAVETVTFHDKKVKYRTGEEA--LSTKL 328

                        330       340
                 ....*....|....*....|..
gi 340007384 334 QKELKAIQYGA--SAHDWMFRV 353
Cdd:PLN03117 329 HLILTNIQMGVveDKKGWMVEI 350
PLN02883 PLN02883
Branched-chain amino acid aminotransferase
 15-353 6.81e-49

Branched-chain amino acid aminotransferase


Pssm-ID: 178471  Cd Length: 384  Bit Score: 168.74  E-value: 6.81e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  15 LLFGKTFTDHMLMVEWNNKAGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARR 94
Cdd:PLN02883  57 LGFSLVRTDFMFATKSCRDGNFEQGYLSRYGNIELNPAAGILNYGQGLIEGMKAYRGEDGRILLFRPELNAMRMKIGAER 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  95 LCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPgDSMTPVSLLA 174
Cdd:PLN02883 137 MCMHSPSVHQFIEGVKQTVLANRRWVPPPGKGSLYLRPLLFGSGASLGVAAAPEYTFLVFGSPVQNYFK-EGTAALNLYV 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 175 DPSFVRAWIGGVGDCKLGGNYGPTVAVQREAQKRGCEQVLWLYG-PDHQLTEVGTMNIFVYWTHedgvlELVTPPLNGVI 253
Cdd:PLN02883 216 EEVIPRAYLGGTGGVKAISNYGPVLEVMRRAKSRGFSDVLYLDAdTGKNIEEVSAANIFLVKGN-----IIVTPATSGTI 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 254 LPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQILYEGKQLHIPTMENGPELILRf 333
Cdd:PLN02883 291 LGGITRKSIIEIALDLG-YKVEERRVPVEELKEA------EEVFCTGTAAGVASVGSITFKNTRTEYKVGDGIVTQQLR- 362

                        330       340
                 ....*....|....*....|..
gi 340007384 334 qKELKAIQYGA--SAHDWMFRV 353
Cdd:PLN02883 363 -SILLGIQTGSiqDTKDWVLQI 383
PLN02259 PLN02259
branched-chain-amino-acid aminotransferase 2
 15-343 7.78e-47

branched-chain-amino-acid aminotransferase 2


Pssm-ID: 177901  Cd Length: 388  Bit Score: 163.35  E-value: 7.78e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  15 LLFGKTFTDHMLMVEWNNKAGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARR 94
Cdd:PLN02259  61 LGFGLNPADYMYVMKCSKDGEFTQGELSPYGNIQLSPSAGVLNYGQAIYEGTKAYRKENGKLLLFRPDHNAIRMKLGAER 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  95 LCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPgDSMTPVSLLA 174
Cdd:PLN02259 141 MLMPSPSVDQFVNAVKQTALANKRWVPPAGKGTLYIRPLLMGSGPILGLGPAPEYTFIVYASPVGNYFK-EGMAALNLYV 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 175 DPSFVRAWIGGVGDCKLGGNYGPTVAVQREAQKRGCEQVLWLYGPDHQ-LTEVGTMNIFVYWTHedgvlELVTPPLNGVI 253
Cdd:PLN02259 220 EEEYVRAAPGGAGGVKSITNYAPVLKALSRAKSRGFSDVLYLDSVKKKyLEEASSCNVFVVKGR-----TISTPATNGTI 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 254 LPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQILYEGKQLHIPTMENgpELILRF 333
Cdd:PLN02259 295 LEGITRKSVMEIASDQG-YQVVEKAVHVDEVMDA------DEVFCTGTAVVVAPVGTITYQEKRVEYKTGDE--SVCQKL 365

                        330
                 ....*....|
gi 340007384 334 QKELKAIQYG 343
Cdd:PLN02259 366 RSVLVGIQTG 375
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 61-311 5.84e-35

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 127.47  E-value: 5.84e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384   61 QLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIEVDKDWVPdgngtslYVRPVLIGNEP 139
Cdd:pfam01063   1 GVFETLRVYNG-----KIFFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVG-------RLRLTVSRGPG 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  140 SLGV-GMVTQALLYVILCPVGSYFPGDSMTPVSLLADPSFVRAwiggvgDCKlGGNYGPTVAVQREAQKRGCEQVLwLYG 218
Cdd:pfam01063  69 GFGLpTSDPTLAIFVSALPPPPESKKKGVISSLVRRNPPSPLP------GAK-TLNYLENVLARREAKAQGADDAL-LLD 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  219 PDHQLTEVGTMNIFvyWTHEDgvlELVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFG 298
Cdd:pfam01063 141 EDGNVTEGSTSNVF--LVKGG---TLYTPPLESGILPGITRQALLDLAKALG-LEVEERPITLADLQEA------DEAFL 208

                         250
                  ....*....|...
gi 340007384  299 SGTACQVCPVHQI 311
Cdd:pfam01063 209 TNSLRGVTPVSSI 221
PRK06606 PRK06606
branched-chain amino acid transaminase;
43-311 5.00e-25

branched-chain amino acid transaminase;


Pssm-ID: 235841  Cd Length: 306  Bit Score: 102.92  E-value: 5.00e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  43 PFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVrLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIEVdkdwvp 121
Cdd:PRK06606  17 PWEDAKVHVLTHALHYGTGVFEGIRAYDTPKGPA-IFRLREHTKRLFNSAKILRMEiPYSVDELMEAQREVVRK------ 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 122 dgNG-TSLYVRP-VLIGNEpSLGV---GMVTQALLYVIlcPVGSYFPGDSMTP-----VS---LLADPSF-VRAwiggvg 187
Cdd:PRK06606  90 --NNlKSAYIRPlVFVGDE-GLGVrphGLPTDVAIAAW--PWGAYLGEEALEKgirvkVSswtRHAPNSIpTRA------ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 188 dcKLGGNYGPTVAVQREAQKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVleLVTPPLNGVILPGVVRQSLLDLAR 267
Cdd:PRK06606 159 --KASGNYLNSILAKTEARRNGYDEALLL-DVEGYVSEGSGENIFIV---RDGV--LYTPPLTSSILEGITRDTVITLAK 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 340007384 268 TWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQI 311
Cdd:PRK06606 231 DLG-IEVIERRITRDELYIA------DEVFFTGTAAEVTPIREV 267
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
 43-311 3.50e-24

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 100.51  E-value: 3.50e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384   43 PFQNLTLHPACSGLHYSLQLFEGLKAYKgGDQQVRLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIEVDkdwvp 121
Cdd:TIGR01122   8 DWEDAKVHVLTHALHYGTGVFEGIRAYD-TDKGPAIFRLKEHIQRLYDSAKIYRMEiPYSKEELMEATRETLRKN----- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  122 dgNGTSLYVRPVLIGNEPSLGVGMVTQAL--LYVILCPVGSYFpGDSMTPVSLLAD-PSFVRAWIGGV-GDCKLGGNYGP 197
Cdd:TIGR01122  82 --NLRSAYIRPLVFRGDGDLGLNPRAGYKpdVIIAAWPWGAYL-GEEALEKGIDAKvSSWRRNAPNTIpTAAKAGGNYLN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  198 TVAVQREAQKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVleLVTPPLNGVILPGVVRQSLLDLARTWGeFRVAER 277
Cdd:TIGR01122 159 SLLAKSEARRHGYDEAILL-DVEGYVAEGSGENIFIV---KDGV--LFTPPVTSSILPGITRDTVITLAKELG-IEVVEQ 231

                         250       260       270
                  ....*....|....*....|....*....|....
gi 340007384  278 KVTMKELKRAleegrvREVFGSGTACQVCPVHQI 311
Cdd:TIGR01122 232 PISREELYTA------DEAFFTGTAAEITPIREV 259
D-AAT_like cd01558
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ...
 54-311 1.22e-23

D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.


Pssm-ID: 238799 [Multi-domain]  Cd Length: 270  Bit Score: 98.44  E-value: 1.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  54 SGLHYSLQLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCLPD-FDKQELLECIRQLIEvdKDWVPDGNGtslYVRP 132
Cdd:cd01558   19 RGFLFGDGVYEVIRVYNG-----KPFALDEHLDRLYRSAKELRIDIpYTREELKELIRELVA--KNEGGEGDV---YIQV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 133 vlignepSLGVGMV-------TQALLYVILCPVGSYFPGDSMTPVSLLADPsfVRAWiggvGDCKL-GGNYGPTVAVQRE 204
Cdd:cd01558   89 -------TRGVGPRghdfpkcVKPTVVIITQPLPLPPAELLEKGVRVITVP--DIRW----LRCDIkSLNLLNNVLAKQE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 205 AQKRGCEQVlWLYGPDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKEL 284
Cdd:cd01558  156 AKEAGADEA-ILLDADGLVTEGSSSNVFIV---KNGVL--VTPPLDNGILPGITRATVIELAKELG-IPVEERPFSLEEL 228

                        250       260
                 ....*....|....*....|....*..
gi 340007384 285 KRAleegrvREVFGSGTACQVCPVHQI 311
Cdd:cd01558  229 YTA------DEVFLTSTTAEVMPVVEI 249
ADCL_like cd01559
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ...
 55-311 8.22e-18

ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.


Pssm-ID: 238800 [Multi-domain]  Cd Length: 249  Bit Score: 81.59  E-value: 8.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  55 GLHYSLQLFEGLKAYKGgdqQVRLFRPWLnmDRMLRSARRLCLPDFDKQELLECIRQLIEVDKdwVPDGngtslYVRPVL 134
Cdd:cd01559    3 GFAYGDGVFETMRALDG---RLFLLDAHL--ARLERSARRLGIPEPDLPRLRAALESLLAAND--IDEG-----RIRLIL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 135 ignepSLGVGmvtqALLYVIL-CPVGSYFPGDSMTPVSLLADPsfVRAWIGGVGDCKLGG-------NYGPTVAVQREAQ 206
Cdd:cd01559   71 -----SRGPG----GRGYAPSvCPGPALYVSVIPLPPAWRQDG--VRLITCPVRLGEQPLlaglkhlNYLENVLAKREAR 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 207 KRGCEQVLWLYGPDHqLTEVGTMNIFvyWTHeDGvlELVTPPLNGVILPGVVRQSLLDLARTWGEfRVAERKVTMKELKR 286
Cdd:cd01559  140 DRGADEALFLDTDGR-VIEGTASNLF--FVK-DG--ELVTPSLDRGGLAGITRQRVIELAAAKGY-AVDERPLRLEDLLA 212

                        250       260
                 ....*....|....*....|....*
gi 340007384 287 AleegrvREVFGSGTACQVCPVHQI 311
Cdd:cd01559  213 A------DEAFLTNSLLGVAPVTAI 231
PRK08320 PRK08320
branched-chain amino acid aminotransferase; Reviewed
 55-311 2.57e-11

branched-chain amino acid aminotransferase; Reviewed


Pssm-ID: 236238 [Multi-domain]  Cd Length: 288  Bit Score: 63.35  E-value: 2.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  55 GLHYSLQLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCL-PDFDKQELLECIRQLIEVDkdwvpdgNGTSLYVRPV 133
Cdd:PRK08320  25 GFLYGDGVFEGIRAYNG-----RVFRLKEHIDRLYDSAKAIMLeIPLSKEEMTEIVLETLRKN-------NLRDAYIRLV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 134 LignepSLGVGMV-------TQALLYVILCPVGSYfPGDsMTPVSLLADPSFVRAWIGGVGDCKLGG-NYGPTVAVQREA 205
Cdd:PRK08320  93 V-----SRGVGDLgldprkcPKPTVVCIAEPIGLY-PGE-LYEKGLKVITVSTRRNRPDALSPQVKSlNYLNNILAKIEA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 206 QKRGCEQVLWLygpDHQ--LTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKE 283
Cdd:PRK08320 166 NLAGVDEAIML---NDEgyVAEGTGDNIFIV---KNGKL--ITPPTYAGALEGITRNAVIEIAKELG-IPVREELFTLHD 236

                        250       260
                 ....*....|....*....|....*...
gi 340007384 284 LKRAleegrvREVFGSGTACQVCPVHQI 311
Cdd:PRK08320 237 LYTA------DEVFLTGTAAEVIPVVKV 258
PRK07544 PRK07544
branched-chain amino acid aminotransferase; Validated
 43-311 5.05e-11

branched-chain amino acid aminotransferase; Validated


Pssm-ID: 181025  Cd Length: 292  Bit Score: 62.69  E-value: 5.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  43 PFQNLTLHPACSGLHYSLQLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLclpDFD----KQELLECIRQLIEVdkd 118
Cdd:PRK07544  19 PWRDAKVHVLTHGLHYASSVFEGERAYGG-----KIFKLREHSERLRRSAELL---DFEipysVAEIDAAKKETLAA--- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 119 wvpdgNG-TSLYVRPVLIGNEPSLGVGMVTQALLYVILC-PVGSYF-PGDSMTPVSL-LA-----DPSF--VRAwiggvg 187
Cdd:PRK07544  88 -----NGlTDAYVRPVAWRGSEMMGVSAQQNKIHLAIAAwEWPSYFdPEAKMKGIRLdIAkwrrpDPETapSAA------ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 188 dcKLGGNYGPTVAVQREAQKRGCEQVLWLygpDH--QLTEVGTMNIFVYwthEDGVLELVTPplnGVILPGVVRQSLLDL 265
Cdd:PRK07544 157 --KAAGLYMICTISKHAAEAKGYADALML---DYrgYVAEATGANIFFV---KDGVIHTPTP---DCFLDGITRQTVIEL 225

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 340007384 266 ARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQI 311
Cdd:PRK07544 226 AKRRG-IEVVERHIMPEELAGF------SECFLTGTAAEVTPVSEI 264
PRK07849 PRK07849
aminodeoxychorismate lyase;
63-287 1.93e-09

aminodeoxychorismate lyase;


Pssm-ID: 236114 [Multi-domain]  Cd Length: 292  Bit Score: 58.05  E-value: 1.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  63 FEGLKAYKGgdqQVRLFRPWLnmDRMLRSARRLCLPDFDKQELLECIRQLIEvdkDWvpDGNGTSLYVRPVLignepSLG 142
Cdd:PRK07849  42 FETLLVRDG---RPCNLEAHL--ERLARSAALLDLPEPDLDRWRRAVELAIE---EW--RAPEDEAALRLVY-----SRG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 143 VGMVTQALLYVILCPVGSYFPGDSMTPVSLL-------ADPSfVRA-WIggvgdckLGG----NYGPTVAVQREAQKRGC 210
Cdd:PRK07849 107 RESGGAPTAWVTVSPVPERVARARREGVSVItldrgypSDAA-ERApWL-------LAGaktlSYAVNMAALRYAARRGA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 211 EQVlwlygpdhqltevgtmnIFvywTHEDG-VLE-------------LVTPPLNGVILPGVVRQSLLDLARTWGeFRVAE 276
Cdd:PRK07849 179 DDV-----------------IF---TSTDGyVLEgptstvviatddrLLTPPPWYGILPGTTQAALFEVAREKG-WDCEY 237

                        250
                 ....*....|.
gi 340007384 277 RKVTMKELKRA 287
Cdd:PRK07849 238 RALRPADLFAA 248
PRK13356 PRK13356
branched-chain amino acid aminotransferase;
83-318 8.96e-08

branched-chain amino acid aminotransferase;


Pssm-ID: 237362  Cd Length: 286  Bit Score: 52.65  E-value: 8.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  83 LNMDRMLRSARRLCL-PDFDKQELLECIRQ-LIEVDKDwvpdgngTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGS 160
Cdd:PRK13356  52 LHCARVNRSAEALGLkPTVSAEEIEALAREgLKRFDPD-------TALYIRPMYWAEDGFASGVAPDPESTRFALCLEEA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 161 YFPGDSMTPVSLladPSFVRAWIG-GVGDCKLGGNYGPTVAVQREAQKRGCEQVLWLYGPDHqLTEVGTMNIFVYwthED 239
Cdd:PRK13356 125 PMPEPTGFSLTL---SPFRRPTLEmAPTDAKAGCLYPNNARALREARSRGFDNALVLDMLGN-VAETATSNVFMV---KD 197

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 340007384 240 GVLelVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQIlyEGKQL 318
Cdd:PRK13356 198 GVV--FTPVPNGTFLNGITRQRVIALLREDG-VTVVETTLTYEDFLEA------DEVFSTGNYSKVVPVTRF--DDRSL 265
PRK12400 PRK12400
D-amino acid aminotransferase; Reviewed
 55-308 1.95e-07

D-amino acid aminotransferase; Reviewed


Pssm-ID: 171470  Cd Length: 290  Bit Score: 51.94  E-value: 1.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384  55 GLHYSLQLFEGLKAYKGgdqQVRLFRPwlNMDRMLRSARR--LCLPdFDKQELLECIRQLIEvDKDWVPDGngtSLYVrp 132
Cdd:PRK12400  29 GLQFGDGVYEVIRLYKG---NFHLLDP--HITRLYRSMEEieLTLP-FSKAELITLLYKLIE-NNNFHEDG---TIYL-- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 133 vlignEPSLGVGMVTQALLYVILCPVGSYfpgdsmtpVSLLADPSF-----VRA-------WIggvgDCKLGG-NYGPTV 199
Cdd:PRK12400  97 -----QVSRGVQARTHTFSYDVPPTIYAY--------ITKKERPALwieygVRAisepdtrWL----RCDIKSlNLLPNI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 200 AVQREAQKRGCEQVLWLYgpDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDLARTWgEFRVAERKV 279
Cdd:PRK12400 160 LAATKAERKGCKEALFVR--NGTVTEGSHSNFFLI---KNGTL--YTHPANHLILNGIIRQYVLSLAKTL-RIPVQEELF 231

                        250       260
                 ....*....|....*....|....*....
gi 340007384 280 TMKELKRAleegrvREVFGSGTACQVCPV 308
Cdd:PRK12400 232 SVRDVYQA------DECFFTGTTIEILPM 254
PRK06680 PRK06680
D-amino acid aminotransferase; Reviewed
 197-318 3.99e-07

D-amino acid aminotransferase; Reviewed


Pssm-ID: 180656 [Multi-domain]  Cd Length: 286  Bit Score: 50.70  E-value: 3.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 197 PTVAVQREAQKRGCeQVLWLYGpDHQLTEVGTMNIFVywTHEDGVLelVTPPLNGVILPGVVRQSLLDLARTWGeFRVAE 276
Cdd:PRK06680 155 PNVLAKQAAKEAGA-QEAWMVD-DGFVTEGASSNAWI--VTKDGKL--VTRPADNFILPGITRHTLIDLAKELG-LEVEE 227

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 340007384 277 RKVTMKELKRAleegrvREVFGSGTACQVCPVHQIlyEGKQL 318
Cdd:PRK06680 228 RPFTLQEAYAA------REAFITAASSFVFPVVQI--DGKQI 261
PLN02845 PLN02845
Branched-chain-amino-acid aminotransferase-like protein
 194-289 1.04e-04

Branched-chain-amino-acid aminotransferase-like protein


Pssm-ID: 215454 [Multi-domain]  Cd Length: 336  Bit Score: 43.46  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340007384 194 NYGPTVAVQREAQKRGCEQVLWLYGpDHQLTEVGTMNI-FVywTHEDgvlELVTPPLNGvILPGVVRQSLLDLA---RTW 269
Cdd:PLN02845 188 NYLPNALSQMEAEERGAFAGIWLDE-EGFVAEGPNMNVaFL--TNDG---ELVLPPFDK-ILSGCTARRVLELAprlVSP 260

                         90       100
                 ....*....|....*....|.
gi 340007384 270 GEFR-VAERKVTMKELKRALE 289
Cdd:PLN02845 261 GDLRgVKQRKISVEEAKAADE 281
PRK07546 PRK07546
hypothetical protein; Provisional
 222-287 4.66e-04

hypothetical protein; Provisional


Pssm-ID: 169002 [Multi-domain]  Cd Length: 209  Bit Score: 40.73  E-value: 4.66e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 340007384 222 QLTEVGTMNIFVywthEDGVLELVTPPLNGVILPGVVRQSLLDlartwgEFRVAERKVTMKELKRA 287
Cdd:PRK07546 136 EVCEGTITNVFL----DRGGGMLTTPPLSCGLLPGVLRAELLD------AGRAREAVLTVDDLKSA 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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