NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|336285206|ref|NP_001229557|]
View 

glucose-fructose oxidoreductase domain-containing protein 1 isoform 2 [Homo sapiens]

Protein Classification

-; -; Gfo/Idh/MocA family oxidoreductase; Gfo/Idh/MocA family oxidoreductase( domain architecture ID 11430574)

-; -; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to biliverdin reductase A (BLVRA)

CATH:  3.40.50.720
Gene Ontology:  GO:0016491|GO:0016651
PubMed:  26749496

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
10-157 6.10e-22

Predicted dehydrogenase [General function prediction only];


:

Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 92.68  E-value: 6.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285206  10 KLMsiMGNVLRFLPAFVRMKQLIEEGYVGEPLVCEVQVHGGSLLGKKyNWSCD-DLMGGGGLHSVGTYIIDLLTFLTGQK 88
Cdd:COG0673  117 VLM--VGFNRRFDPAVRAARELIDSGAIGEIRSVRARFGHPRPAGPA-DWRFDpELAGGGALLDLGIHDIDLARWLLGSE 193

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285206  89 AVKVHGLLKTFVKQTDHIkgirqitsDDFCTFQMVLEGGVCCTVTLNFNVP-GEFKQDVTVVGSAGRLLA 157
Cdd:COG0673  194 PESVSATGGRLVPDRVEV--------DDTAAATLRFANGAVATLEASWVAPgGERDERLEVYGTKGTLFV 255
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
10-157 6.10e-22

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 92.68  E-value: 6.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285206  10 KLMsiMGNVLRFLPAFVRMKQLIEEGYVGEPLVCEVQVHGGSLLGKKyNWSCD-DLMGGGGLHSVGTYIIDLLTFLTGQK 88
Cdd:COG0673  117 VLM--VGFNRRFDPAVRAARELIDSGAIGEIRSVRARFGHPRPAGPA-DWRFDpELAGGGALLDLGIHDIDLARWLLGSE 193

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285206  89 AVKVHGLLKTFVKQTDHIkgirqitsDDFCTFQMVLEGGVCCTVTLNFNVP-GEFKQDVTVVGSAGRLLA 157
Cdd:COG0673  194 PESVSATGGRLVPDRVEV--------DDTAAATLRFANGAVATLEASWVAPgGERDERLEVYGTKGTLFV 255
GFO_IDH_MocA_C pfam02894
Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or ...
 29-256 6.41e-09

Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 427044  Cd Length: 203  Bit Score: 54.73  E-value: 6.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285206   29 KQLIEEGYVGEPLVCEVQVHGGSLLGKKY-NWSCDDLMGGGGLHSVGTYIIDLLTFLTGQKAVKVhgllktfvkqtdhik 107
Cdd:pfam02894   1 KELIENGVLGEVVMVTVHTRDPFRPPQEFkRWRVDPEKSGGALYDLGIHTIDLLIYLFGEPPSVV--------------- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285206  108 giRQITSDDFCTFQMVLEGGVCCTV-TLNFNVPGEFKQDVTVVGSAGRLLAVGTDLYGQRNSAPEQEL-LVQDATPVSNS 185
Cdd:pfam02894  66 --AVYASEDTAFATLEFKNGAVGTLeTSGGSIVEANGHRISIHGTKGSIELDGIDDGLLSVTVVGEPGwATDDPMVRKGG 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 336285206  186 LLPEKAFSDIPSPYLRGTIKMMQAVRQAFqdqddrrtwdgrplTMAATFDDCLYALCVVDTIKRSSQTGEW 256
Cdd:pfam02894 144 DEVPEFLGSFAGGYLLEYDAFLEAVRGGK--------------VVLVDAEDGLYALAVIEAAYESAEEGRP 200
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
10-157 6.10e-22

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 92.68  E-value: 6.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285206  10 KLMsiMGNVLRFLPAFVRMKQLIEEGYVGEPLVCEVQVHGGSLLGKKyNWSCD-DLMGGGGLHSVGTYIIDLLTFLTGQK 88
Cdd:COG0673  117 VLM--VGFNRRFDPAVRAARELIDSGAIGEIRSVRARFGHPRPAGPA-DWRFDpELAGGGALLDLGIHDIDLARWLLGSE 193

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285206  89 AVKVHGLLKTFVKQTDHIkgirqitsDDFCTFQMVLEGGVCCTVTLNFNVP-GEFKQDVTVVGSAGRLLA 157
Cdd:COG0673  194 PESVSATGGRLVPDRVEV--------DDTAAATLRFANGAVATLEASWVAPgGERDERLEVYGTKGTLFV 255
GFO_IDH_MocA_C pfam02894
Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or ...
 29-256 6.41e-09

Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 427044  Cd Length: 203  Bit Score: 54.73  E-value: 6.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285206   29 KQLIEEGYVGEPLVCEVQVHGGSLLGKKY-NWSCDDLMGGGGLHSVGTYIIDLLTFLTGQKAVKVhgllktfvkqtdhik 107
Cdd:pfam02894   1 KELIENGVLGEVVMVTVHTRDPFRPPQEFkRWRVDPEKSGGALYDLGIHTIDLLIYLFGEPPSVV--------------- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336285206  108 giRQITSDDFCTFQMVLEGGVCCTV-TLNFNVPGEFKQDVTVVGSAGRLLAVGTDLYGQRNSAPEQEL-LVQDATPVSNS 185
Cdd:pfam02894  66 --AVYASEDTAFATLEFKNGAVGTLeTSGGSIVEANGHRISIHGTKGSIELDGIDDGLLSVTVVGEPGwATDDPMVRKGG 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 336285206  186 LLPEKAFSDIPSPYLRGTIKMMQAVRQAFqdqddrrtwdgrplTMAATFDDCLYALCVVDTIKRSSQTGEW 256
Cdd:pfam02894 144 DEVPEFLGSFAGGYLLEYDAFLEAVRGGK--------------VVLVDAEDGLYALAVIEAAYESAEEGRP 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH