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Conserved domains on  [gi|320202974|ref|NP_001189336|]
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zinc finger protein 559 isoform c [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-495 6.70e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 6.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 106 NCNQCETAFSQHLHlvckktsQNLHlvcKKTHTQEKPYKCSD--CEKGLPSSSHLRECVRIYGGERPYTH----KEYVET 179
Cdd:COG5048   35 SCPNCTDSFSRLEH-------LTRH---IRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslPLSNSK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 180 FSHSTALFVHMQTQDGEKfyeCKACGKPFTESSYLTQHLRTHSRVLPIEHKKFGKAFAFSPdLAKHIRLRTRGkhyvcNE 259
Cdd:COG5048  105 ASSSSLSSSSSNSNDNNL---LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP-QSNSLHPPLPA-----NS 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 260 CGKEFTCFSKLNIHIRVHTGEKPYECNKCGKAFTDSSGLIKHRRTHTGEKPYECKECGkaFANSSHLTVHMRTHTGEK-- 337
Cdd:COG5048  176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSds 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 338 PYQCKECGKAFINSSSFKSHMQTHPGV-------KPYDCQQCGKAFIRSSFLIRHLRSHSAE----RPFECEE--CGKAF 404
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLF 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 405 RYSSHLSQHKRIHTGERPYKC-------------------------------------QKCGQAFSISSGLTVHMRTHTG 447
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEkllnssskfspllnneppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLS 413

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 320202974 448 ERP--FECQECGKAFTRSTYLIRHLRSHSvEKPYKECGQTFSNSSCLTEC 495
Cdd:COG5048  414 FRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLS 462
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-495 6.70e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 6.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 106 NCNQCETAFSQHLHlvckktsQNLHlvcKKTHTQEKPYKCSD--CEKGLPSSSHLRECVRIYGGERPYTH----KEYVET 179
Cdd:COG5048   35 SCPNCTDSFSRLEH-------LTRH---IRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslPLSNSK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 180 FSHSTALFVHMQTQDGEKfyeCKACGKPFTESSYLTQHLRTHSRVLPIEHKKFGKAFAFSPdLAKHIRLRTRGkhyvcNE 259
Cdd:COG5048  105 ASSSSLSSSSSNSNDNNL---LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP-QSNSLHPPLPA-----NS 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 260 CGKEFTCFSKLNIHIRVHTGEKPYECNKCGKAFTDSSGLIKHRRTHTGEKPYECKECGkaFANSSHLTVHMRTHTGEK-- 337
Cdd:COG5048  176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSds 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 338 PYQCKECGKAFINSSSFKSHMQTHPGV-------KPYDCQQCGKAFIRSSFLIRHLRSHSAE----RPFECEE--CGKAF 404
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLF 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 405 RYSSHLSQHKRIHTGERPYKC-------------------------------------QKCGQAFSISSGLTVHMRTHTG 447
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEkllnssskfspllnneppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLS 413

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 320202974 448 ERP--FECQECGKAFTRSTYLIRHLRSHSvEKPYKECGQTFSNSSCLTEC 495
Cdd:COG5048  414 FRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLS 462
zf-H2C2_2 pfam13465
Zinc-finger double domain;
325-350 1.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 320202974  325 HLTVHMRTHTGEKPYQCKECGKAFIN 350
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 281-332 8.08e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 8.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 320202974 281 KPYeCNKCGKAFTDSSGLIKHRRTHTgekpYECKECGKAFANSSHLTVHMRT 332
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-495 6.70e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 6.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 106 NCNQCETAFSQHLHlvckktsQNLHlvcKKTHTQEKPYKCSD--CEKGLPSSSHLRECVRIYGGERPYTH----KEYVET 179
Cdd:COG5048   35 SCPNCTDSFSRLEH-------LTRH---IRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslPLSNSK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 180 FSHSTALFVHMQTQDGEKfyeCKACGKPFTESSYLTQHLRTHSRVLPIEHKKFGKAFAFSPdLAKHIRLRTRGkhyvcNE 259
Cdd:COG5048  105 ASSSSLSSSSSNSNDNNL---LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP-QSNSLHPPLPA-----NS 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 260 CGKEFTCFSKLNIHIRVHTGEKPYECNKCGKAFTDSSGLIKHRRTHTGEKPYECKECGkaFANSSHLTVHMRTHTGEK-- 337
Cdd:COG5048  176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSds 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 338 PYQCKECGKAFINSSSFKSHMQTHPGV-------KPYDCQQCGKAFIRSSFLIRHLRSHSAE----RPFECEE--CGKAF 404
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLF 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 405 RYSSHLSQHKRIHTGERPYKC-------------------------------------QKCGQAFSISSGLTVHMRTHTG 447
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEkllnssskfspllnneppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLS 413

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 320202974 448 ERP--FECQECGKAFTRSTYLIRHLRSHSvEKPYKECGQTFSNSSCLTEC 495
Cdd:COG5048  414 FRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLS 462
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-415 3.71e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 249 RTRGKHYVCNECGKEFTCFSKLNIHIR--VHTGE--KPYEC--NKCGKAFTDSSGLIKHRRTHTGEKPYECKEC------ 316
Cdd:COG5048  284 KGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskf 363

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 317 GKAFANSSHLTVHMR-THTGEKPYQC--KECGKAFINSSSFKSHMQTHPGVKPY--DCQQCGKAFIRSSFLIRHLRSHSA 391
Cdd:COG5048  364 SPLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTN 443

                        170       180
                 ....*....|....*....|....
gi 320202974 392 ERPFECEECGKaFRYSSHLSQHKR 415
Cdd:COG5048  444 HAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
281-390 1.31e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 281 KPYECNKCGKAFTDSSGLIKHRRTHTGEKPYEC--KECGKAFANSSHLTVHMRTHTGEKPY-QCKECGKAFINSSSFKSH 357
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                         90       100       110
                 ....*....|....*....|....*....|...
gi 320202974 358 MQTHPGVKPYDCQQCGKAFIRSSFLIRHLRSHS 390
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS 144
zf-H2C2_2 pfam13465
Zinc-finger double domain;
325-350 1.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 320202974  325 HLTVHMRTHTGEKPYQCKECGKAFIN 350
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
438-462 5.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.38e-04
                          10        20
                  ....*....|....*....|....*
gi 320202974  438 LTVHMRTHTGERPFECQECGKAFTR 462
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-322 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*
gi 320202974  298 LIKHRRTHTGEKPYECKECGKAFAN 322
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 279-334 1.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.44e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320202974 279 GEKPYECN--KCGKAFTDSSGLIKHR-------RTH------------TGEKPYECKECGKAFANSSHLTVHmRTHT 334
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 311-333 1.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|...
gi 320202974  311 YECKECGKAFANSSHLTVHMRTH 333
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
255-445 2.38e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 255 YVCNECGKEFTCFSKLNIHIRVHTGEKPYECNK--CGKAFTDSSGLIKHRRTHTGEKPYEC-KECGKAFANSSHLTVHMR 331
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320202974 332 THTGEKPYQCKECGKAFINSSSFKSHMQTHPGVKPYDCQQCGKAFIRS--SFLIRHLRSHSaerpfecEECGKAFRYSSH 409
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPAN-------SLSKDPSSNLSL 186

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 320202974 410 LSQHKRIHTGERPYKCQKCGQAFSISSGLTVHMRTH 445
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN 222
zf-H2C2_2 pfam13465
Zinc-finger double domain;
409-433 2.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.88e-03
                          10        20
                  ....*....|....*....|....*
gi 320202974  409 HLSQHKRIHTGERPYKCQKCGQAFS 433
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-293 5.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.74e-03
                          10        20
                  ....*....|....*....|....
gi 320202974  270 LNIHIRVHTGEKPYECNKCGKAFT 293
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 281-332 8.08e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 8.08e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 320202974 281 KPYeCNKCGKAFTDSSGLIKHRRTHTgekpYECKECGKAFANSSHLTVHMRT 332
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 283-305 9.15e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.15e-03
                          10        20
                  ....*....|....*....|...
gi 320202974  283 YECNKCGKAFTDSSGLIKHRRTH 305
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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