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Conserved domains on  [gi|315360618|ref|NP_001186744|]
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gamma-glutamylcyclotransferase isoform 2 [Homo sapiens]

Protein Classification

gamma-glutamylcyclotransferase family protein( domain architecture ID 10159924)

gamma-glutamylcyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl

CATH:  3.10.490.10
EC:  2.3.2.-
Gene Ontology:  GO:0016746
PubMed:  18515354|20110353
SCOP:  4002485

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GGCT_like cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 19-97 8.73e-19

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


:

Pssm-ID: 119400  Cd Length: 99  Bit Score: 76.23  E-value: 8.73e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 315360618  19 YFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGnsqgktsqtWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEW 97
Cdd:cd06661    1 LFVYGTLMDGEVLHARLGRALFLGPATLKGYRLVFG---------GGSGYPGLVPGPGARVWGELYEVDPEDLARLDAF 70
 
Name Accession Description Interval E-value
GGCT_like cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 19-97 8.73e-19

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


Pssm-ID: 119400  Cd Length: 99  Bit Score: 76.23  E-value: 8.73e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 315360618  19 YFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGnsqgktsqtWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEW 97
Cdd:cd06661    1 LFVYGTLMDGEVLHARLGRALFLGPATLKGYRLVFG---------GGSGYPGLVPGPGARVWGELYEVDPEDLARLDAF 70
AIG2_2 pfam13772
AIG2-like family; This family is found in bacteria and metazoa.
 78-97 1.31e-03

AIG2-like family; This family is found in bacteria and metazoa.


Pssm-ID: 433465  Cd Length: 83  Bit Score: 36.08  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|
gi 315360618   78 EVWGVVWKMNKSNLNSLDEW 97
Cdd:pfam13772   1 HVFGVLWEIPMENLKDLDKQ 20
YtfP COG2105
Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family [Amino acid ...
 18-97 1.76e-03

Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family [Amino acid transport and metabolism];


Pssm-ID: 441708 [Multi-domain]  Cd Length: 114  Bit Score: 36.40  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315360618  18 LYFAYGSNLLTERIHLRNPSAAFFCVARLQdFKLdfgnsqgktsqtWH-GGIATIFQSPGDEVWGVVWKMNKSNLNSLDE 96
Cdd:COG2105    2 LLFVYGTLRRGESNHHLLRGARFLGPATLE-GRL------------YDlGAYPALVPDGGGRVYGELYEVDDALLAALDE 68


                 .
gi 315360618  97 W 97
Cdd:COG2105   69 L 69
 
Name Accession Description Interval E-value
GGCT_like cd06661
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) ...
 19-97 8.73e-19

GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).


Pssm-ID: 119400  Cd Length: 99  Bit Score: 76.23  E-value: 8.73e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 315360618  19 YFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGnsqgktsqtWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEW 97
Cdd:cd06661    1 LFVYGTLMDGEVLHARLGRALFLGPATLKGYRLVFG---------GGSGYPGLVPGPGARVWGELYEVDPEDLARLDAF 70
AIG2_2 pfam13772
AIG2-like family; This family is found in bacteria and metazoa.
 78-97 1.31e-03

AIG2-like family; This family is found in bacteria and metazoa.


Pssm-ID: 433465  Cd Length: 83  Bit Score: 36.08  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|
gi 315360618   78 EVWGVVWKMNKSNLNSLDEW 97
Cdd:pfam13772   1 HVFGVLWEIPMENLKDLDKQ 20
YtfP COG2105
Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family [Amino acid ...
 18-97 1.76e-03

Predicted gamma-glutamylamine cyclotransferase YtfP, GGCT/AIG2-like family [Amino acid transport and metabolism];


Pssm-ID: 441708 [Multi-domain]  Cd Length: 114  Bit Score: 36.40  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315360618  18 LYFAYGSNLLTERIHLRNPSAAFFCVARLQdFKLdfgnsqgktsqtWH-GGIATIFQSPGDEVWGVVWKMNKSNLNSLDE 96
Cdd:COG2105    2 LLFVYGTLRRGESNHHLLRGARFLGPATLE-GRL------------YDlGAYPALVPDGGGRVYGELYEVDDALLAALDE 68


                 .
gi 315360618  97 W 97
Cdd:COG2105   69 L 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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