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Conserved domains on  [gi|315113911|ref|NP_001186628|]
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ATP-dependent RNA helicase DHX33 isoform 2 [Homo sapiens]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 1000776)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; similar to ATP-dependent RNA helicase that is involved in translation initiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-527 3.00e-120

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 373.26  E-value: 3.00e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVK-AAQKRRKELgklplKVIVMSATMDVDLFSQYFNGAPVLYLE 79
Cdd:COG1643  110 ILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLdLQPALRPDL-----KLLVMSATLDAERFARLLGDAPVIESS 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  80 GRQHPIQVFYT--KQPQNDYLHAALVSVFQIHQEAPssQDILVFLTGQEEIEamsKTCRDIAKHLPDGCpamLVLPLYAS 157
Cdd:COG1643  185 GRTYPVEVRYRplPADERDLEDAVADAVREALAEEP--GDILVFLPGEREIR---RTAEALRGRLPPDT---EILPLYGR 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 158 LPYAQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGRED 237
Cdd:COG1643  257 LSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLA 336

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 238 SGICYRLYTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLLGALehkDDQLTL 317
Cdd:COG1643  337 PGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGAL---DADGRL 413

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 318 TPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDsvlhnPPSRREevqgvrkkfisSEGDHMTLLNIYRTFK 397
Cdd:COG1643  414 TPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSER-----DPRRGA-----------AGSDLLARLNLWRRLR 477

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 398 NlggnkdwCKENFVNSKNMTLVAEVRAQLRDIClkmSMPIASSRGDVESVRRCLAHSLfmstaelqPD---------GTY 468
Cdd:COG1643  478 E-------QQREFLSYLRLREWRDLARQLRRLL---GEGANEEPADYEAIGLLLALAY--------PDriarrrgegGRY 539

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315113911 469 ATTDTHQpVAIHPSSVLFHcKPACVVyTELLYTNkcymRD---LCV--IDAQWLYEAAPEYFRR 527
Cdd:COG1643  540 LLARGRG-AALFPGSPLAK-KEWLVA-AELVGGA----AEariRLAapIDPEWLEELAAHLIKR 596
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-527 3.00e-120

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 373.26  E-value: 3.00e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVK-AAQKRRKELgklplKVIVMSATMDVDLFSQYFNGAPVLYLE 79
Cdd:COG1643  110 ILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLdLQPALRPDL-----KLLVMSATLDAERFARLLGDAPVIESS 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  80 GRQHPIQVFYT--KQPQNDYLHAALVSVFQIHQEAPssQDILVFLTGQEEIEamsKTCRDIAKHLPDGCpamLVLPLYAS 157
Cdd:COG1643  185 GRTYPVEVRYRplPADERDLEDAVADAVREALAEEP--GDILVFLPGEREIR---RTAEALRGRLPPDT---EILPLYGR 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 158 LPYAQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGRED 237
Cdd:COG1643  257 LSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLA 336

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 238 SGICYRLYTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLLGALehkDDQLTL 317
Cdd:COG1643  337 PGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGAL---DADGRL 413

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 318 TPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDsvlhnPPSRREevqgvrkkfisSEGDHMTLLNIYRTFK 397
Cdd:COG1643  414 TPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSER-----DPRRGA-----------AGSDLLARLNLWRRLR 477

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 398 NlggnkdwCKENFVNSKNMTLVAEVRAQLRDIClkmSMPIASSRGDVESVRRCLAHSLfmstaelqPD---------GTY 468
Cdd:COG1643  478 E-------QQREFLSYLRLREWRDLARQLRRLL---GEGANEEPADYEAIGLLLALAY--------PDriarrrgegGRY 539

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315113911 469 ATTDTHQpVAIHPSSVLFHcKPACVVyTELLYTNkcymRD---LCV--IDAQWLYEAAPEYFRR 527
Cdd:COG1643  540 LLARGRG-AALFPGSPLAK-KEWLVA-AELVGGA----AEariRLAapIDPEWLEELAAHLIKR 596
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 1-527 1.77e-104

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 340.59  E-value: 1.77e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911     1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELgklplKVIVMSATMDVDLFSQYFNGAPVLYLEG 80
Cdd:TIGR01967  166 ILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDL-----KIIITSATIDPERFSRHFNNAPIIEVSG 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911    81 RQHPIQVFY------TKQPQNDYLHAALVSVFQIHQEAPSsqDILVFLTGQEEIeamsktcRDIAKHLPDGCPAML-VLP 153
Cdd:TIGR01967  241 RTYPVEVRYrplveeQEDDDLDQLEAILDAVDELFAEGPG--DILIFLPGEREI-------RDAAEILRKRNLRHTeILP 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   154 LYASLPYAQQLRVFQgaPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRA 233
Cdd:TIGR01967  312 LYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRC 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   234 GREDSGICYRLYTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLLGALEHKDD 313
Cdd:TIGR01967  390 GRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEA 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   314 QLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHNPPSRREEVQGVRKKFISSEGDHMTLLNIY 393
Cdd:TIGR01967  470 EPQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARFKDPRSDFLSRVNLW 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   394 RTF----KNLGGN--KDWCKENFVNSKNMTLVAEVRAQLRDICLKMSMPIASSRGDVESVRRCLAHSLF----MSTAELQ 463
Cdd:TIGR01967  550 RHIeeqrQALSANqfRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLsqigMKDEKHE 629

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315113911   464 PDGTYATTdthqpVAIHPSSVLFHCKPACVVYTELLYTNKCYMRDLCVIDAQWLYEAAPEYFRR 527
Cdd:TIGR01967  630 YDGARGRK-----FHIFPGSPLFKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGHLIKK 688
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 1-517 1.84e-96

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 318.54  E-value: 1.84e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911    1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELgklplKVIVMSATMDVDLFSQYFNGAPVLYLEG 80
Cdd:PRK11131  173 ILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDL-----KVIITSATIDPERFSRHFNNAPIIEVSG 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   81 RQHPIQVFY------TKQPQNDYLHAALVSVFQIHQEAPSsqDILVFLTGQEEI----EAMSKtcrdiaKHLPDgcpaML 150
Cdd:PRK11131  248 RTYPVEVRYrpiveeADDTERDQLQAIFDAVDELGREGPG--DILIFMSGEREIrdtaDALNK------LNLRH----TE 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  151 VLPLYASLPYAQQLRVFQgaPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRT 230
Cdd:PRK11131  316 ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRK 393

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  231 GRAGREDSGICYRLYTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLLGAL-- 308
Cdd:PRK11131  394 GRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAItt 473

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  309 EHKDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHNPPSRREEVQGVRKKFISSEGDHMT 388
Cdd:PRK11131  474 DEQASAYKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKESDFLA 553

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  389 LLNIYRTF----KNLGGN--KDWCKENFVNSKNMTLVAEVRAQLRDICLKMSMPIASSRGDVESVRRCLAHSLFMSTAEL 462
Cdd:PRK11131  554 FVNLWNYLqeqqKALSSNqfRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLSHIGMK 633

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 315113911  463 QPDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTELLYTNKCYMRDLCVIDAQWL 517
Cdd:PRK11131  634 DAEKQEYTGARNARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPEWI 688
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 83-245 2.52e-74

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 232.81  E-value: 2.52e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  83 HPIQVFYTKQPQN-----------DYLHAALVSVFQIHQEAPSSqDILVFLTGQEEIEAMSKTCRDIAKHlpDGCPAMLV 151
Cdd:cd18791    1 FPVEVYYLEDILEllgissekedpDYVDAAVRLILQIHRTEEPG-DILVFLPGQEEIERLCELLREELLS--PDLGKLLV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 152 LPLYASLPYAQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTG 231
Cdd:cd18791   78 LPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAG 157

                        170
                 ....*....|....
gi 315113911 232 RAGREDSGICYRLY 245
Cdd:cd18791  158 RAGRTRPGKCYRLY 171
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 305-390 7.03e-24

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 95.41  E-value: 7.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   305 LGALehkDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVlhNPPSRREEVQGVRKKFISSEG 384
Cdd:smart00847   2 LGAL---DDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDP--RPKEKREDADAARRRFADPES 76


                   ....*.
gi 315113911   385 DHMTLL 390
Cdd:smart00847  77 DHLTLL 82
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 298-389 4.41e-23

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 93.84  E-value: 4.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  298 AIAQLDLLGALehkDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHNPPS---------- 367
Cdd:pfam04408   1 ALELLYYLGAL---DEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaa 77

                          90       100
                  ....*....|....*....|....*..
gi 315113911  368 ---RREEVQGVRKKFISS--EGDHMTL 389
Cdd:pfam04408  78 rrrRRAADEKARAKFARLdlEGDHLTL 104
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
1-527 3.00e-120

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 373.26  E-value: 3.00e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVK-AAQKRRKELgklplKVIVMSATMDVDLFSQYFNGAPVLYLE 79
Cdd:COG1643  110 ILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLdLQPALRPDL-----KLLVMSATLDAERFARLLGDAPVIESS 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  80 GRQHPIQVFYT--KQPQNDYLHAALVSVFQIHQEAPssQDILVFLTGQEEIEamsKTCRDIAKHLPDGCpamLVLPLYAS 157
Cdd:COG1643  185 GRTYPVEVRYRplPADERDLEDAVADAVREALAEEP--GDILVFLPGEREIR---RTAEALRGRLPPDT---EILPLYGR 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 158 LPYAQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGRED 237
Cdd:COG1643  257 LSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLA 336

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 238 SGICYRLYTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLLGALehkDDQLTL 317
Cdd:COG1643  337 PGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGAL---DADGRL 413

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 318 TPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDsvlhnPPSRREevqgvrkkfisSEGDHMTLLNIYRTFK 397
Cdd:COG1643  414 TPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSER-----DPRRGA-----------AGSDLLARLNLWRRLR 477

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 398 NlggnkdwCKENFVNSKNMTLVAEVRAQLRDIClkmSMPIASSRGDVESVRRCLAHSLfmstaelqPD---------GTY 468
Cdd:COG1643  478 E-------QQREFLSYLRLREWRDLARQLRRLL---GEGANEEPADYEAIGLLLALAY--------PDriarrrgegGRY 539

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315113911 469 ATTDTHQpVAIHPSSVLFHcKPACVVyTELLYTNkcymRD---LCV--IDAQWLYEAAPEYFRR 527
Cdd:COG1643  540 LLARGRG-AALFPGSPLAK-KEWLVA-AELVGGA----AEariRLAapIDPEWLEELAAHLIKR 596
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 1-527 1.77e-104

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 340.59  E-value: 1.77e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911     1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELgklplKVIVMSATMDVDLFSQYFNGAPVLYLEG 80
Cdd:TIGR01967  166 ILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDL-----KIIITSATIDPERFSRHFNNAPIIEVSG 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911    81 RQHPIQVFY------TKQPQNDYLHAALVSVFQIHQEAPSsqDILVFLTGQEEIeamsktcRDIAKHLPDGCPAML-VLP 153
Cdd:TIGR01967  241 RTYPVEVRYrplveeQEDDDLDQLEAILDAVDELFAEGPG--DILIFLPGEREI-------RDAAEILRKRNLRHTeILP 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   154 LYASLPYAQQLRVFQgaPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRA 233
Cdd:TIGR01967  312 LYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRC 389

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   234 GREDSGICYRLYTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLLGALEHKDD 313
Cdd:TIGR01967  390 GRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEA 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   314 QLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHNPPSRREEVQGVRKKFISSEGDHMTLLNIY 393
Cdd:TIGR01967  470 EPQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARFKDPRSDFLSRVNLW 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   394 RTF----KNLGGN--KDWCKENFVNSKNMTLVAEVRAQLRDICLKMSMPIASSRGDVESVRRCLAHSLF----MSTAELQ 463
Cdd:TIGR01967  550 RHIeeqrQALSANqfRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLsqigMKDEKHE 629

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 315113911   464 PDGTYATTdthqpVAIHPSSVLFHCKPACVVYTELLYTNKCYMRDLCVIDAQWLYEAAPEYFRR 527
Cdd:TIGR01967  630 YDGARGRK-----FHIFPGSPLFKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGHLIKK 688
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 1-517 1.84e-96

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 318.54  E-value: 1.84e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911    1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELgklplKVIVMSATMDVDLFSQYFNGAPVLYLEG 80
Cdd:PRK11131  173 ILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDL-----KVIITSATIDPERFSRHFNNAPIIEVSG 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   81 RQHPIQVFY------TKQPQNDYLHAALVSVFQIHQEAPSsqDILVFLTGQEEI----EAMSKtcrdiaKHLPDgcpaML 150
Cdd:PRK11131  248 RTYPVEVRYrpiveeADDTERDQLQAIFDAVDELGREGPG--DILIFMSGEREIrdtaDALNK------LNLRH----TE 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  151 VLPLYASLPYAQQLRVFQgaPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRT 230
Cdd:PRK11131  316 ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRK 393

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  231 GRAGREDSGICYRLYTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLLGAL-- 308
Cdd:PRK11131  394 GRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAItt 473

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  309 EHKDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHNPPSRREEVQGVRKKFISSEGDHMT 388
Cdd:PRK11131  474 DEQASAYKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKESDFLA 553

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  389 LLNIYRTF----KNLGGN--KDWCKENFVNSKNMTLVAEVRAQLRDICLKMSMPIASSRGDVESVRRCLAHSLFMSTAEL 462
Cdd:PRK11131  554 FVNLWNYLqeqqKALSSNqfRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLSHIGMK 633

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 315113911  463 QPDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTELLYTNKCYMRDLCVIDAQWL 517
Cdd:PRK11131  634 DAEKQEYTGARNARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPEWI 688
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 83-245 2.52e-74

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 232.81  E-value: 2.52e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  83 HPIQVFYTKQPQN-----------DYLHAALVSVFQIHQEAPSSqDILVFLTGQEEIEAMSKTCRDIAKHlpDGCPAMLV 151
Cdd:cd18791    1 FPVEVYYLEDILEllgissekedpDYVDAAVRLILQIHRTEEPG-DILVFLPGQEEIERLCELLREELLS--PDLGKLLV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 152 LPLYASLPYAQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTG 231
Cdd:cd18791   78 LPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAG 157

                        170
                 ....*....|....
gi 315113911 232 RAGREDSGICYRLY 245
Cdd:cd18791  158 RAGRTRPGKCYRLY 171
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 8-334 4.21e-62

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 217.87  E-value: 4.21e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   8 SDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklPLKVIVMSATMDVDLFSQYFNGAPVLYLEGRQHPIQV 87
Cdd:PRK11664 110 RDPELSGVGLVILDEFHERSLQADLALALLLDVQQGLRD----DLKLLIMSATLDNDRLQQLLPDAPVIVSEGRSFPVER 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  88 FYTKQPQNDYLHAAL-VSVFQIHQEAPSSqdILVFLTGQEEIeamsktcRDIAKHLPDGCPA-MLVLPLYASLPYAQQLR 165
Cdd:PRK11664 186 RYQPLPAHQRFDEAVaRATAELLRQESGS--LLLFLPGVGEI-------QRVQEQLASRVASdVLLCPLYGALSLAEQQK 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 166 VFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLY 245
Cdd:PRK11664 257 AILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLY 336

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 246 TEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLLGALehkDDQLTLTPMGRKMA 325
Cdd:PRK11664 337 SKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGAL---DGQGRLTARGRKMA 413


                 ....*....
gi 315113911 326 AFPLEPKFA 334
Cdd:PRK11664 414 ALGNDPRLA 422
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 1-78 1.79e-47

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 162.91  E-value: 1.79e-47
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNGAPVLYL 78
Cdd:cd17978  101 MLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEQKLSPLKVIIMSATLDADLFSEYFNGAPVLYI 178
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 1-77 2.52e-33

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 124.11  E-value: 2.52e-33
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklpLKVIVMSATMDVDLFSQYFNGAPVLY 77
Cdd:cd17917   87 ILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPD-----LKVILMSATLDAEKFSSYFGGAPVIH 158
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 1-76 1.11e-27

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 109.43  E-value: 1.11e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklpLKVIVMSATMDVDLFSQYFNGAPVL 76
Cdd:cd17973  115 MLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD-----LKLIVMSATLDAGKFQKYFDNAPLL 185
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 1-75 2.44e-24

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 99.86  E-value: 2.44e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklpLKVIVMSATMDVDLFSQYFNGAPV 75
Cdd:cd17971  106 MLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPD-----LKLIVTSATLDAVKFSQYFYEAPI 175
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 305-390 7.03e-24

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 95.41  E-value: 7.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   305 LGALehkDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVlhNPPSRREEVQGVRKKFISSEG 384
Cdd:smart00847   2 LGAL---DDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDP--RPKEKREDADAARRRFADPES 76


                   ....*.
gi 315113911   385 DHMTLL 390
Cdd:smart00847  77 DHLTLL 82
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 298-389 4.41e-23

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 93.84  E-value: 4.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  298 AIAQLDLLGALehkDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHNPPS---------- 367
Cdd:pfam04408   1 ALELLYYLGAL---DEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaa 77

                          90       100
                  ....*....|....*....|....*..
gi 315113911  368 ---RREEVQGVRKKFISS--EGDHMTL 389
Cdd:pfam04408  78 rrrRRAADEKARAKFARLdlEGDHLTL 104
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 1-78 3.45e-21

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 90.64  E-value: 3.45e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklpLKVIVMSATMDVDLFSQYFNGAPVLYL 78
Cdd:cd17974  102 MLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPD-----LKLLISSATMDAEKFSAFFDDAPIFRI 174
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 1-71 5.04e-21

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 90.61  E-value: 5.04e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklpLKVIVMSATMDVDLFSQYFN 71
Cdd:cd17980  103 MLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGD-----LRLIVASATLDAEKFRDFFN 168
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 1-75 1.29e-20

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 89.06  E-value: 1.29e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklpLKVIVMSATMDVDLFSQYFNGAPV 75
Cdd:cd17983  101 ILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRD-----LKLIVTSATMDADKFADFFGNVPI 170
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 2-78 4.59e-20

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 87.60  E-value: 4.59e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 315113911   2 LLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNGAPVLYL 78
Cdd:cd17984  102 LLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATLELAKLSAFFGNCPVFDI 178
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 2-68 2.66e-18

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 83.17  E-value: 2.66e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 315113911   2 LLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELGK-----LPLKVIVMSATMDVDLFSQ 68
Cdd:cd17982  106 LLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKLYLqdqtvKPLKLVIMSATLRVEDFTE 177
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 1-76 6.06e-18

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 81.35  E-value: 6.06e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklpLKVIVMSATMDVDLFSQYFNGAPVL 76
Cdd:cd17989  101 ILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPD-----LKVIITSATIDAERFSRHFNNAPII 171
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 1-76 9.68e-18

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 80.95  E-value: 9.68e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklpLKVIVMSATMDVDLFSQYFNGAPVL 76
Cdd:cd17979   98 LLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPD-----LKLILMSATINIELFSGYFEGAPVV 168
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 447-524 1.46e-16

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 74.60  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  447 VRRCLAHSLFMSTAELQPDG-TYATTDTHQPVAIHPSSVLFHC---KPACVVYTELLYTNKCYMRDLCVIDAQWLYEAAP 522
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGkGYTTLSDNQRVFIHPSSVLFNEktfPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80


                  ..
gi 315113911  523 EY 524
Cdd:pfam07717  81 HI 82
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 1-76 7.34e-15

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 72.75  E-value: 7.34e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklPLKVIVMSATMDVDLFSQYFNGAPVL 76
Cdd:cd17990  101 VLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLLRD----DLRLLAMSATLDGDGLAALLPEAPVV 172
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 1-78 1.64e-14

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 71.80  E-value: 1.64e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklpLKVIVMSATMDVDLFSQYFNGAPVLYL 78
Cdd:cd17981  108 IVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSD-----LKVILMSATLNAEKFSDYFNNCPMIHI 180
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 1-78 2.44e-14

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 71.02  E-value: 2.44e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELgklplKVIVMSATMDVDLFSQYFNGAPVLYL 78
Cdd:cd17985  105 VLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDL-----KVILMSATLNAELFSDYFNSCPVIHI 177
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 1-76 1.05e-12

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 66.48  E-value: 1.05e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklpLKVIVMSATMDVDLFSQYFNGAPVL 76
Cdd:cd17975  111 VLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSD-----LHLILMSATVDCEKFSSYFTHCPIL 181
HELICc smart00490
helicase superfamily c-terminal domain;
151-235 4.78e-12

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 61.84  E-value: 4.78e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   151 VLPLYASLPYAQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMvkakkynpdsglevlavqRVSKTQAWQRT 230
Cdd:smart00490  14 VARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------PWSPASYIQRI 75


                   ....*
gi 315113911   231 GRAGR 235
Cdd:smart00490  76 GRAGR 80
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 7-249 5.10e-12

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 68.47  E-value: 5.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   7 ISDSLLRKYSCVILDEAHERTIHTDVLFGVVkaaqkrRKELGKLPlKVIVMSATM--DVDLFSQYFNGAPVLYLEGRQ-H 83
Cdd:PHA02653 284 LTLNKLFDYGTVIIDEVHEHDQIGDIIIAVA------RKHIDKIR-SLFLMTATLedDRDRIKEFFPNPAFVHIPGGTlF 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  84 PIQVFYTKQPQNDYLHAA--------LVSVFQIHQEAPSSQDIlVFLtgqeeiEAMSKtCRDIAKHLPDGCPAMLVLPLY 155
Cdd:PHA02653 357 PISEVYVKNKYNPKNKRAyieeekknIVTALKKYTPPKGSSGI-VFV------ASVSQ-CEEYKKYLEKRLPIYDFYIIH 428

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911 156 ASLPYAQQ-LRVFQGAPKgyRKVIISTNIAETSITITGIKYVVDTGMVKAKKynPDSGLEVLavqrVSKTQAWQRTGRAG 234
Cdd:PHA02653 429 GKVPNIDEiLEKVYSSKN--PSIIISTPYLESSVTIRNATHVYDTGRVYVPE--PFGGKEMF----ISKSMRTQRKGRVG 500

                        250
                 ....*....|....*
gi 315113911 235 REDSGICYRLYTEDE 249
Cdd:PHA02653 501 RVSPGTYVYFYDLDL 515
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 1-76 7.03e-12

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 64.08  E-value: 7.03e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklpLKVIVMSATMDVDLFSQYFNGAPVL 76
Cdd:cd17977  104 MLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPE-----LKLVIITCPHLSSKLLSYYGNVPLI 174
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 107-235 1.74e-11

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 61.07  E-value: 1.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911  107 QIHQEAPSSQdILVFLTGQEEIEAMSKTCRDIAKhlpdgcpamlVLPLYASLPYAQQLRVFQGAPKGYRKVIISTNIAET 186
Cdd:pfam00271   8 ELLKKERGGK-VLIFSQTKKTLEAELLLEKEGIK----------VARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 315113911  187 SITITGIKYVVDtgmvkakkYNPDSGLEVLavqrvsktqaWQRTGRAGR 235
Cdd:pfam00271  77 GLDLPDVDLVIN--------YDLPWNPASY----------IQRIGRAGR 107
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 1-76 2.16e-11

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 62.50  E-value: 2.16e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKElgklpLKVIVMSATMDVDLFSQYFNGAPVL 76
Cdd:cd17976  106 VLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPE-----LRVVLMSATGDNQRLSRYFGGCPVV 176
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 1-78 5.27e-11

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 61.38  E-value: 5.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   1 MLLREAIS-DSLLRKYSCVILDEAHERTIHTDVLFgvvkaaQKRRKELGKLP-LKVIVMSATMDVDLFSQYFNGAPVLYL 78
Cdd:cd17987  103 VLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLL------TKLRDILQKHPnLKLILSSAALDVNLFIRYFGSCPVIYI 176
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 1-76 1.70e-09

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 58.31  E-value: 1.70e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 315113911   1 MLLREAisDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELgklplKVIVMSATMDVDLFSQYFNGAPVL 76
Cdd:cd17972  164 VLLRKL--EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDL-----RVILMSATIDTSMFCEYFFNCPVI 232
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 1-75 1.09e-08

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 54.90  E-value: 1.09e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELgKLplkVIVMSATMDVDLFSqYFNGAPV 75
Cdd:cd17986  105 LLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPEL-RV---VVVTSPALEPKLRA-FWGNPPV 174
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 1-70 1.90e-07

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 51.35  E-value: 1.90e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911   1 MLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVkaaqKRRKELGKLPLKVIVMSATMDVDLFSQYF 70
Cdd:cd17988  103 VLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVV----RRLLRTNSRHVKIILMSATISCKEFADYF 168
DEXDc smart00487
DEAD-like helicases superfamily;
1-88 5.63e-06

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 47.10  E-value: 5.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 315113911     1 MLLREAISDSL-LRKYSCVILDEAHERT--IHTDVLFGVVKAAQKRRkelgklplKVIVMSATM--DVDLFSQYFNGAPV 75
Cdd:smart00487 115 RLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKLLPKNV--------QLLLLSATPpeEIENLLELFLNDPV 186

                           90
                   ....*....|....*
gi 315113911    76 LYLEGR--QHPIQVF 88
Cdd:smart00487 187 FIDVGFtpLEPIEQF 201
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 176-245 6.33e-05

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 41.54  E-value: 6.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 315113911 176 KVIISTNIAETSITITGIKYVVDTGMVKakkynpdsglevlavqrvSKTQAWQRTGRAGR--EDSGICYRLY 245
Cdd:cd18785   24 EILVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGRggKDEGEVILFV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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