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Conserved domains on  [gi|312222781|ref|NP_001185924|]
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NAD kinase isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pnk super family cl28462
bifunctional NADP phosphatase/NAD kinase;
64-401 4.17e-94

bifunctional NADP phosphatase/NAD kinase;


The actual alignment was detected with superfamily member PLN02727:

Pssm-ID: 333282 [Multi-domain]  Cd Length: 986  Bit Score: 303.35  E-value: 4.17e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  64 QRLTWNKSPKSVLVIKKMRDAsLLQPFKELCTHLM-EENMIVYVEKKVLEdpAIASDESFGAVKkkfcTF-REDYDDISN 141
Cdd:PLN02727 670 QMLMWKSTPKTVLLLKKLGQE-LMEEAKEVASFLYhQEKMNVLVEPDVHD--IFARIPGFGFVQ----TFySQDTSDLHE 742

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 142 QIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAA-----VVLRSRLKVRVVKel 216
Cdd:PLN02727 743 RVDFVACLGGDGVILHASNLFRGAVPPVVSFNLGSLGFLTSHYFEDFRQDLRQVIHGNNTldgvyITLRMRLRCEIFR-- 820

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 217 rgkktavhnglgeNGSQAAGLDMDVgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 296
Cdd:PLN02727 821 -------------NGKAMPGKVFDV---------LNEVVVDRGSNPYLSKIECYEHDRLITKVQGDGVIVATPTGSTAYS 878

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 297 AAAGASMIHPNVPAIMITPICPHSLSFRPIVVP--AGVELKImlSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLP 374
Cdd:PLN02727 879 TAAGGSMVHPNVPCMLFTPICPHSLSFRPVILPdsARLELKI--PDDARSNAWVSFDGKRRQQLSRGDSVRISMSQHPLP 956

                        330       340
                 ....*....|....*....|....*..
gi 312222781 375 SICVRDPVSDWFESLAQCLHWNVRKKQ 401
Cdd:PLN02727 957 TVNKSDQTGDWFRSLIRCLNWNERLDQ 983
 
Name Accession Description Interval E-value
PLN02727 PLN02727
NAD kinase
 64-401 4.17e-94

NAD kinase


Pssm-ID: 215386 [Multi-domain]  Cd Length: 986  Bit Score: 303.35  E-value: 4.17e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  64 QRLTWNKSPKSVLVIKKMRDAsLLQPFKELCTHLM-EENMIVYVEKKVLEdpAIASDESFGAVKkkfcTF-REDYDDISN 141
Cdd:PLN02727 670 QMLMWKSTPKTVLLLKKLGQE-LMEEAKEVASFLYhQEKMNVLVEPDVHD--IFARIPGFGFVQ----TFySQDTSDLHE 742

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 142 QIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAA-----VVLRSRLKVRVVKel 216
Cdd:PLN02727 743 RVDFVACLGGDGVILHASNLFRGAVPPVVSFNLGSLGFLTSHYFEDFRQDLRQVIHGNNTldgvyITLRMRLRCEIFR-- 820

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 217 rgkktavhnglgeNGSQAAGLDMDVgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 296
Cdd:PLN02727 821 -------------NGKAMPGKVFDV---------LNEVVVDRGSNPYLSKIECYEHDRLITKVQGDGVIVATPTGSTAYS 878

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 297 AAAGASMIHPNVPAIMITPICPHSLSFRPIVVP--AGVELKImlSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLP 374
Cdd:PLN02727 879 TAAGGSMVHPNVPCMLFTPICPHSLSFRPVILPdsARLELKI--PDDARSNAWVSFDGKRRQQLSRGDSVRISMSQHPLP 956

                        330       340
                 ....*....|....*....|....*..
gi 312222781 375 SICVRDPVSDWFESLAQCLHWNVRKKQ 401
Cdd:PLN02727 957 TVNKSDQTGDWFRSLIRCLNWNERLDQ 983
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
73-398 4.26e-60

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 196.51  E-value: 4.26e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  73 KSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAiasdesfgavkkkfctfreDYDDISNQIDFIICLGGD 152
Cdd:COG0061    2 KRIAIVAKPGKPEALEAAEELAELLEERGIEVVLDEDTAVPGV-------------------PLEELGEEADLVIVLGGD 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 153 GTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKElrgkktavhnglgengs 232
Cdd:COG0061   63 GTLLRAARLLAPLGIPILGINLGRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATVDRD----------------- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 233 qaagldmdvGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTgstayaaaagasMIHPNVPAIM 312
Cdd:COG0061  126 ---------GEVVHEALALNEVVVLRGSIARMIELEVYIDGEFLEEFRGDGLIVSTPTgstaynlsaggpIVHPGLDALV 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 313 ITPICPHSLSFRPIVVPAGVELKIMLSPEARNtAWVSFDGRKRQEIRHGDSISITTSCYPLpSIcVRDPVSDWFESLAQC 392
Cdd:COG0061  197 LTPIAPHTLSSRPLVLPDDSEIEIEVLEDSRP-AVLVADGQEVRDLEPGDRVEIRRSPKPV-RL-LRLKDHSFFERLREK 273


                 ....*.
gi 312222781 393 LHWNVR 398
Cdd:COG0061  274 LGWGGD 279
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 251-376 5.52e-31

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 115.09  E-value: 5.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  251 LNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPA 330
Cdd:pfam20143   1 LNEVVYVRGPGATMIEFELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPICPHSLSSRPIVVSS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 312222781  331 GVELKIMlsPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSI 376
Cdd:pfam20143  81 SSKLRIR--VLSRAEALLVDDGDPELDISPGDRVRVRKSYYKAKFI 124
 
Name Accession Description Interval E-value
PLN02727 PLN02727
NAD kinase
 64-401 4.17e-94

NAD kinase


Pssm-ID: 215386 [Multi-domain]  Cd Length: 986  Bit Score: 303.35  E-value: 4.17e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  64 QRLTWNKSPKSVLVIKKMRDAsLLQPFKELCTHLM-EENMIVYVEKKVLEdpAIASDESFGAVKkkfcTF-REDYDDISN 141
Cdd:PLN02727 670 QMLMWKSTPKTVLLLKKLGQE-LMEEAKEVASFLYhQEKMNVLVEPDVHD--IFARIPGFGFVQ----TFySQDTSDLHE 742

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 142 QIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAA-----VVLRSRLKVRVVKel 216
Cdd:PLN02727 743 RVDFVACLGGDGVILHASNLFRGAVPPVVSFNLGSLGFLTSHYFEDFRQDLRQVIHGNNTldgvyITLRMRLRCEIFR-- 820

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 217 rgkktavhnglgeNGSQAAGLDMDVgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 296
Cdd:PLN02727 821 -------------NGKAMPGKVFDV---------LNEVVVDRGSNPYLSKIECYEHDRLITKVQGDGVIVATPTGSTAYS 878

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 297 AAAGASMIHPNVPAIMITPICPHSLSFRPIVVP--AGVELKImlSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLP 374
Cdd:PLN02727 879 TAAGGSMVHPNVPCMLFTPICPHSLSFRPVILPdsARLELKI--PDDARSNAWVSFDGKRRQQLSRGDSVRISMSQHPLP 956

                        330       340
                 ....*....|....*....|....*..
gi 312222781 375 SICVRDPVSDWFESLAQCLHWNVRKKQ 401
Cdd:PLN02727 957 TVNKSDQTGDWFRSLIRCLNWNERLDQ 983
PLN02935 PLN02935
Bifunctional NADH kinase/NAD(+) kinase
 66-401 1.86e-89

Bifunctional NADH kinase/NAD(+) kinase


Pssm-ID: 215505 [Multi-domain]  Cd Length: 508  Bit Score: 279.79  E-value: 1.86e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  66 LTWNKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMI-VYVEKKVLEDpAIASDESFGAVKKkfCTFREDYDDISNQID 144
Cdd:PLN02935 188 LKWESDPQTVLIITKPNSTSVRVLCAEMVRWLREQKGLnIYVEPRVKKE-LLSESSYFNFVQT--WEDEKEILLLHTKVD 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 145 FIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKElrgkktAVH 224
Cdd:PLN02935 265 LVITLGGDGTVLWAASMFKGPVPPVVPFSMGSLGFMTPFHSEQYRDCLDAILKGPISITLRHRLQCHIIRD------AAK 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 225 NGLGENGSqaagldmdvgkqamqYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMI 304
Cdd:PLN02935 339 NEYETEEP---------------ILVLNEVTIDRGISSFLTNLECYCDNSFVTCVQGDGLILSTTSGSTAYSLAAGGSMV 403

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 305 HPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDPVSD 384
Cdd:PLN02935 404 HPQVPGILFTPICPHSLSFRPLILPEYVTIRVQVPFNSRGQAWASFDGKDRKQLSAGDALVCSMAPWPVPTACQVESTND 483

                        330
                 ....*....|....*..
gi 312222781 385 WFESLAQCLHWNVRKKQ 401
Cdd:PLN02935 484 FLRSIHDGLHWNLRKTQ 500
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
73-398 4.26e-60

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 196.51  E-value: 4.26e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  73 KSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAiasdesfgavkkkfctfreDYDDISNQIDFIICLGGD 152
Cdd:COG0061    2 KRIAIVAKPGKPEALEAAEELAELLEERGIEVVLDEDTAVPGV-------------------PLEELGEEADLVIVLGGD 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 153 GTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKElrgkktavhnglgengs 232
Cdd:COG0061   63 GTLLRAARLLAPLGIPILGINLGRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATVDRD----------------- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 233 qaagldmdvGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTgstayaaaagasMIHPNVPAIM 312
Cdd:COG0061  126 ---------GEVVHEALALNEVVVLRGSIARMIELEVYIDGEFLEEFRGDGLIVSTPTgstaynlsaggpIVHPGLDALV 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 313 ITPICPHSLSFRPIVVPAGVELKIMLSPEARNtAWVSFDGRKRQEIRHGDSISITTSCYPLpSIcVRDPVSDWFESLAQC 392
Cdd:COG0061  197 LTPIAPHTLSSRPLVLPDDSEIEIEVLEDSRP-AVLVADGQEVRDLEPGDRVEIRRSPKPV-RL-LRLKDHSFFERLREK 273


                 ....*.
gi 312222781 393 LHWNVR 398
Cdd:COG0061  274 LGWGGD 279
ppnK PRK01231
NAD(+) kinase;
69-398 1.46e-37

NAD(+) kinase;


Pssm-ID: 179257 [Multi-domain]  Cd Length: 295  Bit Score: 137.78  E-value: 1.46e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  69 NKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLE-----DPAIASDESFGAVkkkfCtfredyddisnqi 143
Cdd:PRK01231   1 MPSFRNIGLIGRLGSSSVVETLRRLKDFLLDRGLEVILDEETAEvlpghGLQTVSRKLLGEV----C------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 144 DFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVrvvkELRGKKTAV 223
Cdd:PRK01231  64 DLVIVVGGDGSLLGAARALARHNVPVLGINRGRLGFLTDIRPDELEFKLAEVLDGHYQEEERFLLEA----EVRRGGEVI 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 224 HNGLGengsqaagldmdvgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASM 303
Cdd:PRK01231 140 GQGDA----------------------LNDVVLHPGKSTRMIEFELYIDGQFVCSQRSDGLIVSTPTGSTAYALSGGGPI 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 304 IHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDpvS 383
Cdd:PRK01231 198 MHPKLDAIVLVPMFPHTLSSRPIVVDGNSEIKIVISKDNRTYPRVSCDGQNSVTLAPGDTVTIRKKPQKLRLIHPLD--Y 275

                        330
                 ....*....|....*
gi 312222781 384 DWFESLAQCLHWNVR 398
Cdd:PRK01231 276 NYYETCRTKLGWGSR 290
pnk PRK14076
bifunctional NADP phosphatase/NAD kinase;
68-369 1.78e-37

bifunctional NADP phosphatase/NAD kinase;


Pssm-ID: 237601 [Multi-domain]  Cd Length: 569  Bit Score: 142.94  E-value: 1.78e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  68 WNKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEdpaiasdesfgAVKKKFCTFREDYDDISNqIDFII 147
Cdd:PRK14076 286 WRIKPTKFGIVSRIDNEEAINLALKIIKYLDSKGIPYELESFLYN-----------KLKNRLNEECNLIDDIEE-ISHII 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 148 CLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKelrgkktavhngl 227
Cdd:PRK14076 354 SIGGDGTVLRASKLVNGEEIPIICINMGTVGFLTEFSKEEIFKAIDSIISGEYEIEKRTKLSGFILK------------- 420

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 228 gengsqaagldmdVGKQAMQYQVLNEVVI-DRGPSSYLsNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHP 306
Cdd:PRK14076 421 -------------DGHQNILPSALNEVVItTKNPAKML-HFEVYVNGELVEEVRADGIIISTPTGSTAYSLSAGGPIVEP 486

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312222781 307 NVPAIMITPICPHSLSFRPIVVPAGVELKIMLSpeaRNTAWVSFDGRKRQEIRHGDSISITTS 369
Cdd:PRK14076 487 TVDGFIIVPICPFKLSSRPLVVSANSEIKIKLL---KKSALVVIDGSIEFEAKKGDEIIFRKS 546
ppnK PRK02155
NAD kinase;
135-396 1.85e-32

NAD kinase;


Pssm-ID: 179379 [Multi-domain]  Cd Length: 291  Bit Score: 123.90  E-value: 1.85e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 135 DYDDISNQIDFIICLGGDGTLL-YASSLFQGSVPPVMAFHlGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVV 213
Cdd:PRK02155  56 TPEEIGARADLAVVLGGDGTMLgIGRQLAPYGVPLIGINH-GRLGFITDIPLDDMQETLPPMLAGNYEEEERMLLEARVV 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 214 KElrgkktavhnglgengsqaagldmdvGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGST 293
Cdd:PRK02155 135 RD--------------------------GEPIFHALAFNDVVVNRSGFSGMVELRVSVDGRFMYNQRSDGLIVATPTGST 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 294 AYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSpEARNTAwVSFDGRKRQEIRHGDSISITTSCYpl 373
Cdd:PRK02155 189 AYALSAGGPILHPQLPGWVLVPIAPHTLSNRPIVLPDDSEVAIQIV-GGRDVS-VNFDMQSLTSLELGDRIEVRRSPH-- 264

                        250       260
                 ....*....|....*....|....
gi 312222781 374 pSICVRDPVS-DWFESLAQCLHWN 396
Cdd:PRK02155 265 -TVRFLHPVGySYYATLRKKLHWN 287
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 251-376 5.52e-31

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 115.09  E-value: 5.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  251 LNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPA 330
Cdd:pfam20143   1 LNEVVYVRGPGATMIEFELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPICPHSLSSRPIVVSS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 312222781  331 GVELKIMlsPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSI 376
Cdd:pfam20143  81 SSKLRIR--VLSRAEALLVDDGDPELDISPGDRVRVRKSYYKAKFI 124
ppnK PRK04539
inorganic polyphosphate/ATP-NAD kinase; Provisional
 93-398 9.57e-31

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179862 [Multi-domain]  Cd Length: 296  Bit Score: 119.58  E-value: 9.57e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  93 LCTHLMEENMIVYVEKKVLEDPAIASDESFGavkkkfCTFReDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAF 172
Cdd:PRK04539  26 LITFLKQHGFTVYLDEVGIKEGCIYTQDTVG------CHIV-NKTELGQYCDLVAVLGGDGTFLSVAREIAPRAVPIIGI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 173 HLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKElrgkktavhnglgengsqaagldmdvGKQAMQYQVLN 252
Cdd:PRK04539  99 NQGHLGFLTQIPREYMTDKLLPVLEGKYLAEERILIEAALIRE--------------------------GKTAERALALN 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 253 EVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGV 332
Cdd:PRK04539 153 DAVLSRGGAGQMIEFEVFVNREFVYTQRSDGLIVSTPTGSTAYSLAAGGPIMQAGLHAFTLVPICPQSMTNRPIAIPDTS 232

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 312222781 333 ELKIMLSP--EARntawVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDpvSDWFESLAQCLHWNVR 398
Cdd:PRK04539 233 EIEILVTQggDAR----VHFDGQTHIDVQNLDRITIRRYRNPLRILHPTD--YQYFKTLRQKLHWGEQ 294
ppnK PRK01911
inorganic polyphosphate/ATP-NAD kinase; Provisional
 91-353 3.19e-29

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179352 [Multi-domain]  Cd Length: 292  Bit Score: 115.41  E-value: 3.19e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  91 KELCTHLMEENMIVYVEKKVLEdpAIASDESFgavKKKFCTFrEDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVM 170
Cdd:PRK01911  19 QELFDELEERGAEVLIEEKFLD--FLKQDLKF---HPSYDTF-SDNEELDGSADMVISIGGDGTFLRTATYVGNSNIPIL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 171 AFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKELRGkktavhnglgenGSQAAgldmdvgkqamqyqv 250
Cdd:PRK01911  93 GINTGRLGFLATVSKEEIEETIDELLNGDYTIEERSLLQLESNPKLFG------------ELNFA--------------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 251 LNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPA 330
Cdd:PRK01911 146 LNEIAILKRDTSSMITVHTYLNGEYLNSYWADGLIVATPTGSTGYSLSCGGPIIVPDAKSFVITPIAPHNLNVRPLVIPD 225

                        250       260
                 ....*....|....*....|....
gi 312222781 331 GVElkIMLSPEARNTAW-VSFDGR 353
Cdd:PRK01911 226 DTE--ITLEVESRSDNFlVSLDSR 247
ppnK PRK01185
NAD(+) kinase;
144-369 3.65e-28

NAD(+) kinase;


Pssm-ID: 179241 [Multi-domain]  Cd Length: 271  Bit Score: 111.83  E-value: 3.65e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 144 DFIICLGGDGTLLYASSLFQGsvpPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVvkelrgkktav 223
Cdd:PRK01185  54 DVIITIGGDGTILRTLQRAKG---PILGINMGGLGFLTEIEIDEVGSAIKKLIRGEYFIDERMKLKVYI----------- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 224 hnglgeNGSQAagldmdvgkqamqYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASM 303
Cdd:PRK01185 120 ------NGERL-------------EDCTNEAVIHTDRIAKIRQFKIYYDGHFLDTFKADGVIVATPTGSTSYSSSAGGPI 180

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312222781 304 IHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTawVSFDGRKRQEIRHGDSISITTS 369
Cdd:PRK01185 181 LLPNLEGMVISYIAPYSSRPKSVVVPSESTVEIKIAGDQSSL--LILDGQYEYKISKGDTVEISKS 244
ppnK PRK03708
NAD(+) kinase;
127-369 4.30e-27

NAD(+) kinase;


Pssm-ID: 179635 [Multi-domain]  Cd Length: 277  Bit Score: 109.03  E-value: 4.30e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 127 KKFCTFRE-DYDDISN-QIDFIICLGGDGTLLYASSLFQGSVpPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVvl 204
Cdd:PRK03708  40 EHLPEFSEeDVLPLEEmDVDFIIAIGGDGTILRIEHKTKKDI-PILGINMGTLGFLTEVEPEETFFALSRLLEGDYFI-- 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 205 RSRLKVRVvkelrgkktaVHNglGENGSQAagldmdvgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGV 284
Cdd:PRK03708 117 DERIKLRV----------YIN--GENVPDA----------------LNEVVILTGIPGKIIHLKYYVDGELADEVRADGL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 285 IVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNtAWVSFDGRKRQEIRHGDSI 364
Cdd:PRK03708 169 IISTPTGSTAYAMSAGGPFVDPRLDAILIAPLCPFKLSSRPMVVPSSSRIDVKLLRTGRE-IILVIDGQYYEELPPDTEI 247


                 ....*
gi 312222781 365 SITTS 369
Cdd:PRK03708 248 TIKKS 252
pnk PRK14077
NAD(+) kinase;
137-395 2.12e-24

NAD(+) kinase;


Pssm-ID: 172567 [Multi-domain]  Cd Length: 287  Bit Score: 101.78  E-value: 2.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 137 DDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKEl 216
Cdd:PRK14077  59 DELFKISDFLISLGGDGTLISLCRKAAEYDKFVLGIHAGHLGFLTDITVDEAEKFFQAFFQGEFEIEKPYMLSVFLEKK- 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 217 RGKktavhnglgengsqaagldmdvgkqAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 296
Cdd:PRK14077 138 QGK-------------------------ILEKLAFNDVVISKNNQASMAHIEAFLNEKYFNEYFGDGVIVATPAGSTAYN 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 297 AAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMlspeARNTAWVSFDGRKRQEIRHGDSISITTScyPLPSI 376
Cdd:PRK14077 193 MSANGPIIYPLSQVFILTPVCSHSLTQRPIVLPKGFEVEFK----TKSDCILCIDGQDRYKMNDFKSIKVGLS--DKNVA 266

                        250
                 ....*....|....*....
gi 312222781 377 CVRDPVSDWFESLAQCLHW 395
Cdd:PRK14077 267 LIRHKNRDYFQILKEKLHW 285
ppnK PRK02645
NAD(+) kinase;
140-395 2.70e-24

NAD(+) kinase;


Pssm-ID: 179455 [Multi-domain]  Cd Length: 305  Bit Score: 101.91  E-value: 2.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 140 SNQIDFIICLGGDGTLLYAS-SLFQGSVPpVMAFHLG-SLGFLT-PFSFENFQSQVTQVIEGNAAVVLRSRLKVRVvkeL 216
Cdd:PRK02645  55 SELIDLAIVLGGDGTVLAAArHLAPHDIP-ILSVNVGgHLGFLThPRDLLQDESVWDRLQEDRYAIERRMMLQARV---F 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 217 RGKKTavhnglgengsqaagldmDVGKQAMQYQVLNE-----VVIDRGPSSYLsnvDVYLDGHLITTVQGDGVIVSTPTG 291
Cdd:PRK02645 131 EGDRS------------------NEEPVSESYYALNDfylkpASEDRSPTCIL---ELEIDGEVVDQYQGDGLIVSTPTG 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 292 STAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAG--VELKIMLSPEARNTAWVsfDGRKRQEIRHGDSISITTS 369
Cdd:PRK02645 190 STAYTMAAGGPILHPGIDAIIVTPICPMSLSSRPIVIPPGsrVVIWPLGDYDLNIKLWK--DGVLATSIWPGQRCVIQKA 267

                        250       260
                 ....*....|....*....|....*.
gi 312222781 370 CYPLPSICVRDPVSdWFESLAQCLHW 395
Cdd:PRK02645 268 RHPAKFIILEESYS-YYRTLREKLHW 292
ppnK PRK03378
inorganic polyphosphate/ATP-NAD kinase; Provisional
 77-373 1.57e-23

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235122 [Multi-domain]  Cd Length: 292  Bit Score: 99.63  E-value: 1.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  77 VIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAIaSDESFGavkkkfctfreDYDDISNQIDFIICLGGDGTLL 156
Cdd:PRK03378  10 IVGHPRHPTALTTHEMLYHWLTSKGYEVIVEQQIAHELQL-KNVKTG-----------TLAEIGQQADLAIVVGGDGNML 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 157 YAS---SLFQGSVPPVmafHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKelrgkktavHNGLGENGSq 233
Cdd:PRK03378  78 GAArvlARYDIKVIGI---NRGNLGFLTDLDPDNALQQLSDVLEGHYISEKRFLLEAQVCR---------HGQQKRIST- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 234 aagldmdvgkqamqyqVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMI 313
Cdd:PRK03378 145 ----------------AINEVVLHPGKVAHMIEFEVYIDDNFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPSLDAITL 208

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 314 TPICPHSLSFRPIVVPAGVELKIMLSPEaRNTAWVSFDGRKRQEIRHGDSISITTSCYPL 373
Cdd:PRK03378 209 VPMFPHTLSARPLVIDSSSTIRLKFSPN-RSDLEISCDSQIALPIQPGEEVLIRRSDYHL 267
ppnK PRK02649
NAD(+) kinase;
143-395 7.31e-19

NAD(+) kinase;


Pssm-ID: 179456 [Multi-domain]  Cd Length: 305  Bit Score: 86.57  E-value: 7.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 143 IDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVvkeLRGKKTa 222
Cdd:PRK02649  69 MKFAIVLGGDGTVLSAARQLAPCGIPLLTINTGHLGFLTEAYLNQLDEAIDQVLAGQYTIEERTMLTVSV---MRGDQL- 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 223 vhngLGENGSqaagldmdvgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGAS 302
Cdd:PRK02649 145 ----RWEALS------------------LNEMVLHREPLTSMCHFEIAIGRHAPVDIAADGVILSTPTGSTAYSLSAGGP 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 303 MIHPNVPAIMITPICPHSLSFRPIVVPAGVELKImlSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDPv 382
Cdd:PRK02649 203 VITPDVPVLQLTPICPHSLASRALVFSDSEPVTV--FPATPERLVMVVDGNAGCYVWPEDRVLIRRSPYPVRFIRLQDP- 279

                        250
                 ....*....|...
gi 312222781 383 sDWFESLAQCLHW 395
Cdd:PRK02649 280 -EFFRVLREKLGW 291
ppnK PRK02231
NAD(+) kinase;
97-395 2.92e-16

NAD(+) kinase;


Pssm-ID: 167337 [Multi-domain]  Cd Length: 272  Bit Score: 78.31  E-value: 2.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781  97 LMEENMIVYVEKKVledpAIASDESFGAVKkkfctfreDYDDISNQIDFIICLGGDGTLL-YASSLFQGSVPpVMAFHLG 175
Cdd:PRK02231   9 LKERGYQVLVEKEI----AEQLNLPENHLA--------SLEEIGQRAQLAIVIGGDGNMLgRARVLAKYDIP-LIGINRG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 176 SLGFLTPFSFENFQSQVTQVIE-GNAAVVLRSRLKVRVvkELRGKKTAVHNGLgengsqaagldmdvgkqamqyqvlNEV 254
Cdd:PRK02231  76 NLGFLTDIDPKNAYEQLEACLErGEFFVEERFLLEAKI--ERNGKIIATSNAL------------------------NEV 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 255 VIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVEL 334
Cdd:PRK02231 130 VIHPAKIAHMIDFHVYIDDKFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPNLNAIALVPMFPHTLSSRPLVIDGDSKI 209

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 312222781 335 KIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDpvSDWFESLAQCLHW 395
Cdd:PRK02231 210 SLRFAEYNTPQLEVSCDSQIALPFTPDDRVHVQKSPDKLRLLHLKN--YNYYNVLSSKLGW 268
pnk PRK14075
NAD(+) kinase;
143-329 1.05e-15

NAD(+) kinase;


Pssm-ID: 184489 [Multi-domain]  Cd Length: 256  Bit Score: 76.31  E-value: 1.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 143 IDFIICLGGDGTLLYASSLFQGsvpPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKelrgkkta 222
Cdd:PRK14075  42 ADLIIVVGGDGTVLKAAKKVGT---PLVGFKAGRLGFLSSYTLEEIDRFLEDLKNWNFREEKRWFLKIESEL-------- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 223 vhnglgengsqaagldmdvgkqaMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGAS 302
Cdd:PRK14075 111 -----------------------GNHLALNDVTLERDPSQKMVEIEVSFEDHSSMWFFADGVVISTPTGSTAYSLSLGGP 167

                        170       180
                 ....*....|....*....|....*..
gi 312222781 303 MIHPNVPAIMITPICPHSLSFRPIVVP 329
Cdd:PRK14075 168 IILPNCEVFEITPIAPQFLATRSIVIP 194
NAD_kinase pfam01513
ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 75-197 3.56e-15

ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86.


Pssm-ID: 426300 [Multi-domain]  Cd Length: 128  Bit Score: 71.63  E-value: 3.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781   75 VLVIKKMRDASLLQPFKELCTHLMEENMI-VYVEKKVLEDPAIASDESFGAVKKKFCTFREDYDDISNQI----DFIICL 149
Cdd:pfam01513   1 VGIVVNPDKKEALERAREVARWLLDRLGItVTVEEKMGESLAFAAGDRPEVIGCLKKVVDDTRRATRAFAdagvDLIIVL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 312222781  150 GGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIE 197
Cdd:pfam01513  81 GGDGTALRAARLLQKAVIPILGVNTGVLGFLTEFEPEAAFELLERLLE 128
ppnK PRK03372
inorganic polyphosphate/ATP-NAD kinase; Provisional
 110-373 3.24e-13

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235121 [Multi-domain]  Cd Length: 306  Bit Score: 69.95  E-value: 3.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 110 VLEDPAIASDESFGAV---KKKFCTFREDyDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFE 186
Cdd:PRK03372  38 RVLDAEAVDLGATHPApddFRAMEVVDAD-PDAADGCELVLVLGGDGTILRAAELARAADVPVLGVNLGHVGFLAEAEAE 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 187 NFQSQVTQVIEGNAAVVLRSRLKVRVvkelRGKKTAVHNGLGengsqaagldmdvgkqamqyqvLNEVVIDRGPSSYLSN 266
Cdd:PRK03372 117 DLDEAVERVVDRDYRVEERMTLDVTV----RVGGEIVWRGWA----------------------LNEASLEKADREGMLE 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 267 VDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEArNTA 346
Cdd:PRK03372 171 VVLEVDGRPVSSFGCDGVLVSTPTGSTAYAFSAGGPVVWPDLEALLVVPLNAHALFARPLVVSPTSTVAVEILADT-SDA 249

                        250       260
                 ....*....|....*....|....*..
gi 312222781 347 WVSFDGRKRQEIRHGDSISITTSCYPL 373
Cdd:PRK03372 250 VLWCDGRRSVDLPPGARVEVRRGATPV 276
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 126-366 7.75e-11

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 62.14  E-value: 7.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 126 KKKFCTFREDYDDisNQIDFIICLGGDGTLLYASSLFQGSVPPVmAF---HLGSLGFLT---PFSFENFqsqVTQVIEGN 199
Cdd:PRK04885  21 KKYLKDFGFILDE--KNPDIVISVGGDGTLLSAFHRYENQLDKV-RFvgvHTGHLGFYTdwrPFEVDKL---VIALAKDP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 200 AAVVLRSRLKVRVVKElrgkktavhnglgeNGSQAAgldmdvgkqamqYQVLNEVVIDRgPSSYLSnVDVYLDGHLITTV 279
Cdd:PRK04885  95 GQVVSYPLLEVKITYE--------------DGEKEK------------YLALNEATIKR-IEGTLV-ADVYINGVLFERF 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 280 QGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICphSLS---FR----PIVVPAGVelKIMLSPEARNTAWVSFDg 352
Cdd:PRK04885 147 RGDGLCVSTPTGSTAYNKSLGGAVLHPSIEALQLTEIA--SINnrvFRtlgsPLILPKHH--TITLKPVNDDDYQITVD- 221

                        250
                 ....*....|....
gi 312222781 353 rkRQEIRHGDSISI 366
Cdd:PRK04885 222 --HLTIKHKNVKSI 233
ppnK PRK04761
inorganic polyphosphate/ATP-NAD kinase; Reviewed
 136-289 2.73e-04

inorganic polyphosphate/ATP-NAD kinase; Reviewed


Pssm-ID: 179876 [Multi-domain]  Cd Length: 246  Bit Score: 42.11  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 136 YDDIS-NQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFL-TPFSFENFQSQVtqviegNAAVVLRSRLKVRVV 213
Cdd:PRK04761  18 YGDVPiEEADVIVALGGDGFMLQTLHRYMNSGKPVYGMNRGSVGFLmNEYSEDDLLERI------AAAEPTVLHPLRMTA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 214 KELRGKktaVHNGLGEN-------GSQAAGLDMDV-GKQAMQyqvlnEVVidrgpssylsnvdvyldghlittvqGDGVI 285
Cdd:PRK04761  92 TDVSGE---VHEALAINevslfrqTRQAAKLRISIdGKVRME-----ELV-------------------------CDGVL 138


                 ....
gi 312222781 286 VSTP 289
Cdd:PRK04761 139 VATP 142
ppnK PRK03501
NAD kinase;
244-290 2.94e-03

NAD kinase;


Pssm-ID: 179584  Cd Length: 264  Bit Score: 39.19  E-value: 2.94e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 312222781 244 QAMQYQVLNEVVIDrgpSSYLSN--VDVYLDGHLITTVQGDGVIVSTPT 290
Cdd:PRK03501 113 GSTSFYCLNEFSIR---SSIIKTfvIDVYIDDLHFETFRGDGMVVSTPT 158
PLN02929 PLN02929
NADH kinase
 130-212 3.19e-03

NADH kinase


Pssm-ID: 215502 [Multi-domain]  Cd Length: 301  Bit Score: 39.25  E-value: 3.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 130 CTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPvmafhLG----------------------SLGFLTPFSFEN 187
Cdd:PLN02929  52 CVLRNELSQPIRDVDLVVAVGGDGTLLQASHFLDDSIPV-----LGvnsdptqkdeveeysdefdarrSTGHLCAATAED 126

                         90       100
                 ....*....|....*....|....*
gi 312222781 188 FQSQVTQVIEGNAAVVLRSRLKVRV 212
Cdd:PLN02929 127 FEQVLDDVLFGRLKPTELSRISTVV 151
ppnK PRK00561
NAD(+) kinase;
141-366 8.09e-03

NAD(+) kinase;


Pssm-ID: 100598 [Multi-domain]  Cd Length: 259  Bit Score: 37.93  E-value: 8.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 141 NQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSF----ENFQSQVTQviegnaavvlrsrLKVRVVKEL 216
Cdd:PRK00561  32 DGADYLFVLGGDGFFVSTAANYNCAGCKVVGINTGHLGFYTSFNEtdldQNFANKLDQ-------------LKFTQIDLL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312222781 217 RgkktavhnglgengsqaagldmdVGKQAMQYQVLNEVVIDrgpSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 296
Cdd:PRK00561  99 E-----------------------VQIDDQIHLVLNELAVY---TNTAYPINIFIDNEFWEKYRGSGLLIGPRTGSTALA 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 312222781 297 AAAGASMIHPNVPAIMITPICP--HSlSF----RPIVVPAGVELKIMLSPEARNTAWVSF--DGRKRQEIRHGDSISI 366
Cdd:PRK00561 153 KSAKGAVIFPRIDVIQIIELNPllHP-NQttiqSPIILPIDTKVEFEIKKAFDHDQFPRFyaDGAKLRLGNSDTTIEI 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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