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Conserved domains on  [gi|525313637|ref|NP_001185763|]
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myomegalin isoform 9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
6-73 2.48e-17

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


:

Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 78.33  E-value: 2.48e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 525313637     6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 73
Cdd:pfam07989    1 REQEKQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAE 68
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
31-679 5.22e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 88.19  E-value: 5.22e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR 408
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   111 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVpgdqvkpdqyTEALAQRDKRIEELNQSLAAQERLVE 190
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEEL----------QEELERLEEALEELREELEEAEQALD 478
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   191 QLSREKQQLLHLLEEPTSMEVQPMTE-ELLKQQKLNSHETTITQQSVSDshLAELQEKIQQteATNKILQEKLNemsyel 269
Cdd:TIGR02168  479 AAERELAQLQARLDSLERLQENLEGFsEGVKALLKNQSGLSGILGVLSE--LISVDEGYEA--AIEAALGGRLQ------ 548
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   270 KCAQESSQKQDGTIQNLKEtlKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALF 349
Cdd:TIGR02168  549 AVVVENLNAAKKAIAFLKQ--NELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVL 626
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   350 CSQ-----LEIQKLQR----------------------------VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKH 396
Cdd:TIGR02168  627 VVDdldnaLELAKKLRpgyrivtldgdlvrpggvitggsaktnsSILERRREIEELEEKIEELEEKIAELEKALAELRKE 706
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   397 NQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEK 476
Cdd:TIGR02168  707 LEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEE 786
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   477 LRQRIHDkavaLERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ 556
Cdd:TIGR02168  787 LEAQIEQ----LKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIE 862
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   557 NLQWLKEEMETKFSRWQKEQESIIQQlqtsLHDRNKEVEDLSATLLcklgpgqsEIAEELcQRLQRKERMLQDLLSDRNK 636
Cdd:TIGR02168  863 ELEELIEELESELEALLNERASLEEA----LALLRSELEELSEELR--------ELESKR-SELRRELEELREKLAQLEL 929
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|...
gi 525313637   637 QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQA 679
Cdd:TIGR02168  930 RLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARR 972
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
388-1111 1.09e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 80.49  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   388 QQKEASWKHNQELRKALQQLQEELQNKSQ-------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYR 460
Cdd:TIGR02168  235 EELREELEELQEELKEAEEELEELTAELQeleekleELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANL 314
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   461 DNSDKTLEANEMLLEKLRQRIHDKAVALERAIDE---KFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSM 537
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELAELEEKLEElkeELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQ 394
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   538 ESLLRAK----GLEVEQLSTTCQNLQWLKEEMETKFSRWQ-KEQESIIQQLQTSLHDRNKEVEDLSATLlcKLGPGQSEI 612
Cdd:TIGR02168  395 IASLNNEierlEARLERLEDRRERLQQEIEELLKKLEEAElKELQAELEELEEELEELQEELERLEEAL--EELREELEE 472
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   613 AEEL-------CQRLQRKERMLQDLL------SDRNKQVLEHEMEIQGLLQSVSTR-------EQESQAAAEKLVQALME 672
Cdd:TIGR02168  473 AEQAldaaereLAQLQARLDSLERLQenlegfSEGVKALLKNQSGLSGILGVLSELisvdegyEAAIEAALGGRLQAVVV 552
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   673 RNSE-----LQALRQYLGGRDSLMsqAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEDVSiprSTLGDLDT 747
Cdd:TIGR02168  553 ENLNaakkaIAFLKQNELGRVTFL--PLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALS---YLLGGVLV 627
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   748 VAGLEKELSNAKEELE----------------LMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811
Cdd:TIGR02168  628 VDDLDNALELAKKLRPgyrivtldgdlvrpggVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKEL 707
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   812 KDLQMQLVDPEDIPamERLTQEVLLLREKVASVESQGQEISgNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKfh 891
Cdd:TIGR02168  708 EELEEELEQLRKEL--EELSRQISALRKDLARLEAEVEQLE-ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEA-- 782
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   892 ahpESSERDRTLQVELEGAQVLRSRLEEVLGRsLERLNRLETLAAIGGAAAGDDTEDTSTEFTDsIEEEAAHHSHQQLvk 971
Cdd:TIGR02168  783 ---EIEELEAQIEQLKEELKALREALDELRAE-LTLLNEEAANLRERLESLERRIAATERRLED-LEEQIEELSEDIE-- 855
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   972 vALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGfSSVSHIRNTMLS 1051
Cdd:TIGR02168  856 -SLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELR-EKLAQLELRLEG 933
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1052 LCLENAELKEQmgeaMSDGWEIEEDkekgevMVETVVTKEGLSESSLQAEFRKLQGKLKN 1111
Cdd:TIGR02168  934 LEVRIDNLQER----LSEEYSLTLE------EAEALENKIEDDEEEARRRLKRLENKIKE 983
Olduvai pfam06758
Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the ...
1552-1621 4.98e-08

Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the Olduvai domain. It is found highly duplicated in the human lineage.


:

Pssm-ID: 429104 [Multi-domain]  Cd Length: 68  Bit Score: 51.65  E-value: 4.98e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1552 DHKSEKDQaglEPLALRLSRELQEKEKViEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACS 1621
Cdd:pfam06758    1 DEEEEEDQ---EPLAPRLSRELPEVEEQ-EVPQDSLDECYLTPSVLPDLSDSYQPYRSTIFSFEEQQVSS 66
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1841-2018 2.92e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 2.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1841 ADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSH 1920
Cdd:COG1196   241 LEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEE 320
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1921 VSREHSQET---ESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQ 1997
Cdd:COG1196   321 LEEELAELEeelEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAA 400
                         170       180
                  ....*....|....*....|.
gi 525313637 1998 QCEEKQQLFESLQSELQIYEA 2018
Cdd:COG1196   401 QLEELEEAEEALLERLERLEE 421
 
Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
6-73 2.48e-17

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 78.33  E-value: 2.48e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 525313637     6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 73
Cdd:pfam07989    1 REQEKQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAE 68
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
31-679 5.22e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 88.19  E-value: 5.22e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR 408
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   111 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVpgdqvkpdqyTEALAQRDKRIEELNQSLAAQERLVE 190
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEEL----------QEELERLEEALEELREELEEAEQALD 478
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   191 QLSREKQQLLHLLEEPTSMEVQPMTE-ELLKQQKLNSHETTITQQSVSDshLAELQEKIQQteATNKILQEKLNemsyel 269
Cdd:TIGR02168  479 AAERELAQLQARLDSLERLQENLEGFsEGVKALLKNQSGLSGILGVLSE--LISVDEGYEA--AIEAALGGRLQ------ 548
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   270 KCAQESSQKQDGTIQNLKEtlKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALF 349
Cdd:TIGR02168  549 AVVVENLNAAKKAIAFLKQ--NELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVL 626
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   350 CSQ-----LEIQKLQR----------------------------VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKH 396
Cdd:TIGR02168  627 VVDdldnaLELAKKLRpgyrivtldgdlvrpggvitggsaktnsSILERRREIEELEEKIEELEEKIAELEKALAELRKE 706
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   397 NQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEK 476
Cdd:TIGR02168  707 LEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEE 786
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   477 LRQRIHDkavaLERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ 556
Cdd:TIGR02168  787 LEAQIEQ----LKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIE 862
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   557 NLQWLKEEMETKFSRWQKEQESIIQQlqtsLHDRNKEVEDLSATLLcklgpgqsEIAEELcQRLQRKERMLQDLLSDRNK 636
Cdd:TIGR02168  863 ELEELIEELESELEALLNERASLEEA----LALLRSELEELSEELR--------ELESKR-SELRRELEELREKLAQLEL 929
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|...
gi 525313637   637 QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQA 679
Cdd:TIGR02168  930 RLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARR 972
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
5-587 8.03e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 84.22  E-value: 8.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    5 YRTLSQHLNDLKKEnfSLKLRIYFLEERMQ------QKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVEN 78
Cdd:COG1196   215 YRELKEELKELEAE--LLLLKLRELEAELEeleaelEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   79 LNS---QNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKEcNLELSEKLKGVTKnwedvp 155
Cdd:COG1196   293 LLAelaRLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEE-LEEAEAELAEAEE------ 365
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  156 gdqvkpdQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEvqpmTEELLKQQKLNSHETTITQQS 235
Cdd:COG1196   366 -------ALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALL----ERLERLEEELEELEEALAELE 434
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  236 VSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLR 315
Cdd:COG1196   435 EEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAAL 514
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  316 EMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALfcsqleiqkLQRVVRqkeRQLADAKQCVQFV--EAAAHESEQQKEAS 393
Cdd:COG1196   515 LLAGLRGLAGAVAVLIGVEAAYEAALEAALAAA---------LQNIVV---EDDEVAAAAIEYLkaAKAGRATFLPLDKI 582
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  394 WKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEML 473
Cdd:COG1196   583 RARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSL 662
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  474 LEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG--LEVEQL 551
Cdd:COG1196   663 TGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEReeLLEELL 742
                         570       580       590
                  ....*....|....*....|....*....|....*.
gi 525313637  552 STTCQNLQWLKEEMETKFSRwqKEQESIIQQLQTSL 587
Cdd:COG1196   743 EEEELLEEEALEELPEPPDL--EELERELERLEREI 776
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
388-1111 1.09e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 80.49  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   388 QQKEASWKHNQELRKALQQLQEELQNKSQ-------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYR 460
Cdd:TIGR02168  235 EELREELEELQEELKEAEEELEELTAELQeleekleELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANL 314
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   461 DNSDKTLEANEMLLEKLRQRIHDKAVALERAIDE---KFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSM 537
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELAELEEKLEElkeELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQ 394
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   538 ESLLRAK----GLEVEQLSTTCQNLQWLKEEMETKFSRWQ-KEQESIIQQLQTSLHDRNKEVEDLSATLlcKLGPGQSEI 612
Cdd:TIGR02168  395 IASLNNEierlEARLERLEDRRERLQQEIEELLKKLEEAElKELQAELEELEEELEELQEELERLEEAL--EELREELEE 472
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   613 AEEL-------CQRLQRKERMLQDLL------SDRNKQVLEHEMEIQGLLQSVSTR-------EQESQAAAEKLVQALME 672
Cdd:TIGR02168  473 AEQAldaaereLAQLQARLDSLERLQenlegfSEGVKALLKNQSGLSGILGVLSELisvdegyEAAIEAALGGRLQAVVV 552
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   673 RNSE-----LQALRQYLGGRDSLMsqAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEDVSiprSTLGDLDT 747
Cdd:TIGR02168  553 ENLNaakkaIAFLKQNELGRVTFL--PLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALS---YLLGGVLV 627
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   748 VAGLEKELSNAKEELE----------------LMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811
Cdd:TIGR02168  628 VDDLDNALELAKKLRPgyrivtldgdlvrpggVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKEL 707
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   812 KDLQMQLVDPEDIPamERLTQEVLLLREKVASVESQGQEISgNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKfh 891
Cdd:TIGR02168  708 EELEEELEQLRKEL--EELSRQISALRKDLARLEAEVEQLE-ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEA-- 782
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   892 ahpESSERDRTLQVELEGAQVLRSRLEEVLGRsLERLNRLETLAAIGGAAAGDDTEDTSTEFTDsIEEEAAHHSHQQLvk 971
Cdd:TIGR02168  783 ---EIEELEAQIEQLKEELKALREALDELRAE-LTLLNEEAANLRERLESLERRIAATERRLED-LEEQIEELSEDIE-- 855
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   972 vALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGfSSVSHIRNTMLS 1051
Cdd:TIGR02168  856 -SLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELR-EKLAQLELRLEG 933
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1052 LCLENAELKEQmgeaMSDGWEIEEDkekgevMVETVVTKEGLSESSLQAEFRKLQGKLKN 1111
Cdd:TIGR02168  934 LEVRIDNLQER----LSEEYSLTLE------EAEALENKIEDDEEEARRRLKRLENKIKE 983
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
395-1131 7.16e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 64.61  E-value: 7.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   395 KHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ---------------------HLNHSLSHKEQLLQEF 453
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKaleyyqlkekleleeeyllylDYLKLNEERIDLLQEL 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   454 RELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEAT 533
Cdd:pfam02463  246 LRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKK 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   534 MQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHD----RNKEVEDLSATLLCKLGPGQ 609
Cdd:pfam02463  326 AEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLeserLSSAAKLKEEELELKSEEEK 405
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   610 SEiaeelcQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQ---ALRQYLGG 686
Cdd:pfam02463  406 EA------QLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKkseDLLKETQL 479
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   687 RDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEdvsiPRSTLGDLDTVAGLEKELSNAKEELELMA 766
Cdd:pfam02463  480 VKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIIS----AHGRLGDLGVAVENYKVAISTAVIVEVSA 555
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   767 KK------ERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQmQLVDPEDIPAMERLTQEVLLLREK 840
Cdd:pfam02463  556 TAdeveerQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDK-ATLEADEDDKRAKVVEGILKDTEL 634
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   841 VASVESQGQEISGNRRQQlllMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEV 920
Cdd:pfam02463  635 TKLKESAKAKESGLRKGV---SLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEE 711
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   921 LGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNpsfsppSPMGGDSNR 1000
Cdd:pfam02463  712 LKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKEL------AEEREKTEK 785
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1001 CLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSlcLENAELKEQMGEAMSDGWEIEEDKEKG 1080
Cdd:pfam02463  786 LKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELE--ELALELKEEQKLEKLAEEELERLEEEI 863
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|.
gi 525313637  1081 EVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIinlLKEQLVLSSKEGN 1131
Cdd:pfam02463  864 TKEELLQELLLKEEELEEQKLKDELESKEEKEKEE---KKELEEESQKLNL 911
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
17-838 2.75e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 62.83  E-value: 2.75e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    17 KENFSLKLRIYFLEER-MQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTwADVENLNSQNEAELRRQFEERQ 95
Cdd:pfam15921   73 KEHIERVLEEYSHQVKdLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAM-ADIRRRESQSQEDLRNQLQNTV 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    96 QETEHVYELLENKI-----QLLQEESRLAKNEAARM---AALVEAEKECNLELSEKLKGVTKNWEDVpGDQVkpdqyTEA 167
Cdd:pfam15921  152 HELEAAKCLKEDMLedsntQIEQLRKMMLSHEGVLQeirSILVDFEEASGKKIYEHDSMSTMHFRSL-GSAI-----SKI 225
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   168 LAQRDKRIEELNQSLAAQERLVEQLSREKQQLLhlleeptsmevqpmteELLKQQKLNSHETTITQQSVsdsHLAELQEK 247
Cdd:pfam15921  226 LRELDTEISYLKGRIFPVEDQLEALKSESQNKI----------------ELLLQQHQDRIEQLISEHEV---EITGLTEK 286
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   248 IQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQviegqndtmAKLREMLHQSQLGQLH 327
Cdd:pfam15921  287 ASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYE---------DKIEELEKQLVLANSE 357
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   328 SSEGTSPAQQqvalLDLQSALFCSQLeiQKLQRVVRQKERQLAdakqcvqfveaaaHESEQQKEAsWKHN-------QEL 400
Cdd:pfam15921  358 LTEARTERDQ----FSQESGNLDDQL--QKLLADLHKREKELS-------------LEKEQNKRL-WDRDtgnsitiDHL 417
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   401 RKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 480
Cdd:pfam15921  418 RRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERT 497
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   481 IHDKAVALEraidEKFSALEEKEKELRQLRLAVRERDHDLERLR---DVLSSNEATMQSMESLLRAKGLEVEQLSTTCQN 557
Cdd:pfam15921  498 VSDLTASLQ----EKERAIEATNAEITKLRSRVDLKLQELQHLKnegDHLRNVQTECEALKLQMAEKDKVIEILRQQIEN 573
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   558 LQWLKEEMETKFSRWQKEQesiiQQLQTSLHDRNKEVEDLSatLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQ 637
Cdd:pfam15921  574 MTQLVGQHGRTAGAMQVEK----AQLEKEINDRRLELQEFK--ILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRA 647
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   638 VLEHEMEIQGLLQSVSTREQESQAAAEKLvqALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGRLGKQTDQGS 717
Cdd:pfam15921  648 VKDIKQERDQLLNEVKTSRNELNSLSEDY--EVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHA 725
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   718 MQIpsrddstSLTAKEDVSIPRSTLGDLDT-VAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAAD 796
Cdd:pfam15921  726 MKV-------AMGMQKQITAKRGQIDALQSkIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQ 798
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|..
gi 525313637   797 MESLTRNIQIKEDLIKDLQMQLVDPEDIpaMERLTQEVLLLR 838
Cdd:pfam15921  799 ERRLKEKVANMEVALDKASLQFAECQDI--IQRQEQESVRLK 838
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
31-554 2.10e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 59.67  E-value: 2.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   31 ERMQQKYEASREDIyKRNIELKVEVESLKReLQDKKQHLDKTWADVENLNSQNE-AELRRQ--------FEERQQETEHv 101
Cdd:PRK02224  179 ERVLSDQRGSLDQL-KAQIEEKEEKDLHER-LNGLESELAELDEEIERYEEQREqARETRDeadevleeHEERREELET- 255
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  102 yelLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEE-LNQ 180
Cdd:PRK02224  256 ---LEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDrLEE 332
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  181 SLAAQERLVEQLSREKQQLLHLLEEPTsmEVQPMTEELlkQQKLNSHETTITQQSvsdSHLAELQEKIQQTEATNKILQE 260
Cdd:PRK02224  333 CRVAAQAHNEEAESLREDADDLEERAE--ELREEAAEL--ESELEEAREAVEDRR---EEIEELEEEIEELRERFGDAPV 405
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  261 KLNEMSYELKCAQESSQKQDGTIQNLKETLKS---RERETEELYQ------------------VIEGQNDTMAKLREMLH 319
Cdd:PRK02224  406 DLGNAEDFLEELREERDELREREAELEATLRTareRVEEAEALLEagkcpecgqpvegsphveTIEEDRERVEELEAELE 485
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  320 QSQLGQ------LHSSEGTSPAQQQVALLDLQSALFCSQLEIQKlqRVVRQKERQLADAKQCVQFVEAAAHESEQQKEAS 393
Cdd:PRK02224  486 DLEEEVeeveerLERAEDLVEAEDRIERLEERREDLEELIAERR--ETIEEKRERAEELRERAAELEAEAEEKREAAAEA 563
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  394 WKHNQELRKALQQLQEELQNKSQQLRAWE--AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEA-- 469
Cdd:PRK02224  564 EEEAEEAREEVAELNSKLAELKERIESLEriRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAef 643
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  470 NEMLLEKLRQRiHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRakglEVE 549
Cdd:PRK02224  644 DEARIEEARED-KERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVEALEALYD----EAE 718

                  ....*
gi 525313637  550 QLSTT 554
Cdd:PRK02224  719 ELESM 723
Olduvai pfam06758
Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the ...
1552-1621 4.98e-08

Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the Olduvai domain. It is found highly duplicated in the human lineage.


Pssm-ID: 429104 [Multi-domain]  Cd Length: 68  Bit Score: 51.65  E-value: 4.98e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1552 DHKSEKDQaglEPLALRLSRELQEKEKViEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACS 1621
Cdd:pfam06758    1 DEEEEEDQ---EPLAPRLSRELPEVEEQ-EVPQDSLDECYLTPSVLPDLSDSYQPYRSTIFSFEEQQVSS 66
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1841-2018 2.92e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 2.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1841 ADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSH 1920
Cdd:COG1196   241 LEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEE 320
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1921 VSREHSQET---ESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQ 1997
Cdd:COG1196   321 LEEELAELEeelEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAA 400
                         170       180
                  ....*....|....*....|.
gi 525313637 1998 QCEEKQQLFESLQSELQIYEA 2018
Cdd:COG1196   401 QLEELEEAEEALLERLERLEE 421
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
474-932 8.22e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 48.11  E-value: 8.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  474 LEKLRQRIHDKAVALERAIDEKFSALEEKEKE------------LRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLL 541
Cdd:PRK02224  164 LEEYRERASDARLGVERVLSDQRGSLDQLKAQieekeekdlherLNGLESELAELDEEIERYEEQREQARETRDEADEVL 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  542 ---RAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEqesiIQQLQTSLHDRNKEVEDLSATllCKLGPGQSEIAEELCQ 618
Cdd:PRK02224  244 eehEERREELETLEAEIEDLRETIAETEREREELAEE----VRDLRERLEELEEERDDLLAE--AGLDDADAEAVEARRE 317
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  619 RLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISN 698
Cdd:PRK02224  318 ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELR 397
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  699 QQAEVTPTgRLGKQTDQGSMQIPSRDDS----TSLTAK---------------------------EDVSIPRSTLGDLDT 747
Cdd:PRK02224  398 ERFGDAPV-DLGNAEDFLEELREERDELrereAELEATlrtarerveeaealleagkcpecgqpvEGSPHVETIEEDRER 476
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  748 VAGLEKELSNAKEELELMAKK-ER-----ESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDP 821
Cdd:PRK02224  477 VEELEAELEDLEEEVEEVEERlERaedlvEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEK 556
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  822 EDipAMERLTQEVLLLREKVASVESQGQEISgNRRQQL------LLMLEGLVDERSRLNEALQA------ERQLYSSlvk 889
Cdd:PRK02224  557 RE--AAAEAEEEAEEAREEVAELNSKLAELK-ERIESLerirtlLAAIADAEDEIERLREKREAlaelndERRERLA--- 630
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 525313637  890 fhahpESSERDRTLQVE-----LEGAQVLRSRLEEVLGRSLERLNRLE 932
Cdd:PRK02224  631 -----EKRERKRELEAEfdearIEEAREDKERAEEYLEQVEEKLDELR 673
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1912-2060 1.20e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.74  E-value: 1.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1912 RRLQAQLSHVSREHS---QETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRL 1988
Cdd:TIGR02168  263 QELEEKLEELRLEVSeleEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 525313637  1989 QHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAysldachqipLSSDLSHLVAEVRALRGQLEQ 2060
Cdd:TIGR02168  343 EEKLEELKEELESLEAELEELEAELEELESRLEELEEQLET----------LRSKVAQLELQIASLNNEIER 404
HAUS5 pfam14817
HAUS augmin-like complex subunit 5; This family includes HAUS augmin-like complex subunit 5. ...
1899-1983 2.87e-03

HAUS augmin-like complex subunit 5; This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis.


Pssm-ID: 464332 [Multi-domain]  Cd Length: 643  Bit Score: 42.73  E-value: 2.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1899 QLCNENRVLREDNRRLQAQL----------SHVSREHSQETESLREA---------LLSSRSHLQELEKELEHQKVERQQ 1959
Cdd:pfam14817  317 QFLNELAETRSRCQQLQARLqglkdeaeleSLGIGDTSQNDSLLRQVlelelqaagLAASRDTLRSECQQLNKLARERQE 396
                           90       100
                   ....*....|....*....|....
gi 525313637  1960 LLEDLREKQQEVLHFREERLSLQE 1983
Cdd:pfam14817  397 ALRSLQKKWQRILDFRQLVSELQE 420
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
738-932 3.05e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  738 PRSTLGDLDTVAGLEKELSNAKEELELmAKKERESQMELSALQSMMAVQEEELQVQAADMESLT-----RNIQIKEDLIK 812
Cdd:COG4913   220 EPDTFEAADALVEHFDDLERAHEALED-AREQIELLEPIRELAERYAAARERLAELEYLRAALRlwfaqRRLELLEAELE 298
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  813 DLQMQLVDPEDipAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLvkfHA 892
Cdd:COG4913   299 ELRAELARLEA--ELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAAL---GL 373
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 525313637  893 HPESSERD-----RTLQVELEGAQVLRSRLEEVLGRSLERLNRLE 932
Cdd:COG4913   374 PLPASAEEfaalrAEAAALLEALEEELEALEEALAEAEAALRDLR 418
 
Name Accession Description Interval E-value
Cnn_1N pfam07989
Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated ...
6-73 2.48e-17

Centrosomin N-terminal motif 1; This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organizing activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.


Pssm-ID: 462333 [Multi-domain]  Cd Length: 69  Bit Score: 78.33  E-value: 2.48e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 525313637     6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTW 73
Cdd:pfam07989    1 REQEKQIDKLKKENFNLKLKIHFLEERLEKLAPEQIEEALKENIELKVELETLQRELKKLKKLLREAE 68
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
31-679 5.22e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 88.19  E-value: 5.22e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR 408
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   111 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVpgdqvkpdqyTEALAQRDKRIEELNQSLAAQERLVE 190
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEEL----------QEELERLEEALEELREELEEAEQALD 478
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   191 QLSREKQQLLHLLEEPTSMEVQPMTE-ELLKQQKLNSHETTITQQSVSDshLAELQEKIQQteATNKILQEKLNemsyel 269
Cdd:TIGR02168  479 AAERELAQLQARLDSLERLQENLEGFsEGVKALLKNQSGLSGILGVLSE--LISVDEGYEA--AIEAALGGRLQ------ 548
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   270 KCAQESSQKQDGTIQNLKEtlKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALF 349
Cdd:TIGR02168  549 AVVVENLNAAKKAIAFLKQ--NELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVL 626
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   350 CSQ-----LEIQKLQR----------------------------VVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKH 396
Cdd:TIGR02168  627 VVDdldnaLELAKKLRpgyrivtldgdlvrpggvitggsaktnsSILERRREIEELEEKIEELEEKIAELEKALAELRKE 706
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   397 NQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEK 476
Cdd:TIGR02168  707 LEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEE 786
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   477 LRQRIHDkavaLERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQ 556
Cdd:TIGR02168  787 LEAQIEQ----LKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIE 862
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   557 NLQWLKEEMETKFSRWQKEQESIIQQlqtsLHDRNKEVEDLSATLLcklgpgqsEIAEELcQRLQRKERMLQDLLSDRNK 636
Cdd:TIGR02168  863 ELEELIEELESELEALLNERASLEEA----LALLRSELEELSEELR--------ELESKR-SELRRELEELREKLAQLEL 929
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|...
gi 525313637   637 QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQA 679
Cdd:TIGR02168  930 RLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARR 972
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
240-1038 3.02e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.88  E-value: 3.02e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   240 HLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLH 319
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA 312
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   320 QSQlgqlhssegTSPAQQQVALLDLQSALFCSQLEIQKLqrvvrqkERQLADAKQCVQFVEAAAHESEQQKEASWKHNQE 399
Cdd:TIGR02168  313 NLE---------RQLEELEAQLEELESKLDELAEELAEL-------EEKLEELKEELESLEAELEELEAELEELESRLEE 376
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   400 LRKALQQLQEELQNKSQQLRAWEaekyNEIRTQEQNIQHLNHSLshkEQLLQEFRELLQYRDNSDktLEANEMLLEKLRQ 479
Cdd:TIGR02168  377 LEEQLETLRSKVAQLELQIASLN----NEIERLEARLERLEDRR---ERLQQEIEELLKKLEEAE--LKELQAELEELEE 447
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   480 RIHDKAVALERAIdekfSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQ 559
Cdd:TIGR02168  448 ELEELQEELERLE----EALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILG 523
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   560 WLKEEMETKfSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEElcqrlqrkermlqDLLSDRNKQVL 639
Cdd:TIGR02168  524 VLSELISVD-EGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPL-------------DSIKGTEIQGN 589
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   640 EHEM--EIQGLLQSVSTREqESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAE-VTPTGRLGKQTDQG 716
Cdd:TIGR02168  590 DREIlkNIEGFLGVAKDLV-KFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYRIVTLDGDlVRPGGVITGGSAKT 668
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   717 SMQIPSRDdSTSLTAKEDVSIPRSTLGDLDT-VAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAA 795
Cdd:TIGR02168  669 NSSILERR-REIEELEEKIEELEEKIAELEKaLAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEE 747
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   796 DMESLTRNIQIKEDLIKDLQMQLvdpedipamERLTQEVLLLREKVASVESQGQEISgNRRQQLLLMLEGLVDERSRLNE 875
Cdd:TIGR02168  748 RIAQLSKELTELEAEIEELEERL---------EEAEEELAEAEAEIEELEAQIEQLK-EELKALREALDELRAELTLLNE 817
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   876 ALQAERQLYSSLVKFHAHPESSERDRT------------LQVELEGAQVLRSRLEEVLGRSLERLNRLET---LAAIGGA 940
Cdd:TIGR02168  818 EAANLRERLESLERRIAATERRLEDLEeqieelsediesLAAEIEELEELIEELESELEALLNERASLEEalaLLRSELE 897
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   941 AAGDDTEDTSTEFTDSieEEAAHHSHQQLVKVALEKSLATVETQNpsfsppspmggdsnrcLQE---EMLHLRAEFHQHL 1017
Cdd:TIGR02168  898 ELSEELRELESKRSEL--RRELEELREKLAQLELRLEGLEVRIDN----------------LQErlsEEYSLTLEEAEAL 959
                          810       820
                   ....*....|....*....|....*.
gi 525313637  1018 EEKR-----KAEEELKELKAQIEEAG 1038
Cdd:TIGR02168  960 ENKIeddeeEARRRLKRLENKIKELG 985
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
5-587 8.03e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 84.22  E-value: 8.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    5 YRTLSQHLNDLKKEnfSLKLRIYFLEERMQ------QKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVEN 78
Cdd:COG1196   215 YRELKEELKELEAE--LLLLKLRELEAELEeleaelEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   79 LNS---QNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKEcNLELSEKLKGVTKnwedvp 155
Cdd:COG1196   293 LLAelaRLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEE-LEEAEAELAEAEE------ 365
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  156 gdqvkpdQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEvqpmTEELLKQQKLNSHETTITQQS 235
Cdd:COG1196   366 -------ALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALL----ERLERLEEELEELEEALAELE 434
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  236 VSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLR 315
Cdd:COG1196   435 EEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAAL 514
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  316 EMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALfcsqleiqkLQRVVRqkeRQLADAKQCVQFV--EAAAHESEQQKEAS 393
Cdd:COG1196   515 LLAGLRGLAGAVAVLIGVEAAYEAALEAALAAA---------LQNIVV---EDDEVAAAAIEYLkaAKAGRATFLPLDKI 582
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  394 WKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEML 473
Cdd:COG1196   583 RARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSL 662
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  474 LEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG--LEVEQL 551
Cdd:COG1196   663 TGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEReeLLEELL 742
                         570       580       590
                  ....*....|....*....|....*....|....*.
gi 525313637  552 STTCQNLQWLKEEMETKFSRwqKEQESIIQQLQTSL 587
Cdd:COG1196   743 EEEELLEEEALEELPEPPDL--EELERELERLEREI 776
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
388-1111 1.09e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 80.49  E-value: 1.09e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   388 QQKEASWKHNQELRKALQQLQEELQNKSQ-------QLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYR 460
Cdd:TIGR02168  235 EELREELEELQEELKEAEEELEELTAELQeleekleELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANL 314
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   461 DNSDKTLEANEMLLEKLRQRIHDKAVALERAIDE---KFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSM 537
Cdd:TIGR02168  315 ERQLEELEAQLEELESKLDELAEELAELEEKLEElkeELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQ 394
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   538 ESLLRAK----GLEVEQLSTTCQNLQWLKEEMETKFSRWQ-KEQESIIQQLQTSLHDRNKEVEDLSATLlcKLGPGQSEI 612
Cdd:TIGR02168  395 IASLNNEierlEARLERLEDRRERLQQEIEELLKKLEEAElKELQAELEELEEELEELQEELERLEEAL--EELREELEE 472
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   613 AEEL-------CQRLQRKERMLQDLL------SDRNKQVLEHEMEIQGLLQSVSTR-------EQESQAAAEKLVQALME 672
Cdd:TIGR02168  473 AEQAldaaereLAQLQARLDSLERLQenlegfSEGVKALLKNQSGLSGILGVLSELisvdegyEAAIEAALGGRLQAVVV 552
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   673 RNSE-----LQALRQYLGGRDSLMsqAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEDVSiprSTLGDLDT 747
Cdd:TIGR02168  553 ENLNaakkaIAFLKQNELGRVTFL--PLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALS---YLLGGVLV 627
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   748 VAGLEKELSNAKEELE----------------LMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811
Cdd:TIGR02168  628 VDDLDNALELAKKLRPgyrivtldgdlvrpggVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKEL 707
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   812 KDLQMQLVDPEDIPamERLTQEVLLLREKVASVESQGQEISgNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKfh 891
Cdd:TIGR02168  708 EELEEELEQLRKEL--EELSRQISALRKDLARLEAEVEQLE-ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEA-- 782
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   892 ahpESSERDRTLQVELEGAQVLRSRLEEVLGRsLERLNRLETLAAIGGAAAGDDTEDTSTEFTDsIEEEAAHHSHQQLvk 971
Cdd:TIGR02168  783 ---EIEELEAQIEQLKEELKALREALDELRAE-LTLLNEEAANLRERLESLERRIAATERRLED-LEEQIEELSEDIE-- 855
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   972 vALEKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGfSSVSHIRNTMLS 1051
Cdd:TIGR02168  856 -SLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELR-EKLAQLELRLEG 933
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1052 LCLENAELKEQmgeaMSDGWEIEEDkekgevMVETVVTKEGLSESSLQAEFRKLQGKLKN 1111
Cdd:TIGR02168  934 LEVRIDNLQER----LSEEYSLTLE------EAEALENKIEDDEEEARRRLKRLENKIKE 983
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
170-879 1.09e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 77.40  E-value: 1.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   170 QRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEpTSMEVQPMTEELLKQQK-LNSH-------ETTITQQSVSDSHL 241
Cdd:TIGR02168  236 ELREELEELQEELKEAEEELEELTAELQELEEKLEE-LRLEVSELEEEIEELQKeLYALaneisrlEQQKQILRERLANL 314
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   242 ----AELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREM 317
Cdd:TIGR02168  315 erqlEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQ 394
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   318 L--HQSQLGQLhSSEGTSPAQQQVALLDLQSALFCSQLE--IQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEAS 393
Cdd:TIGR02168  395 IasLNNEIERL-EARLERLEDRRERLQQEIEELLKKLEEaeLKELQAELEELEEELEELQEELERLEEALEELREELEEA 473
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   394 WKHNQELR----------KALQQLQEELQNKSQQLRAWEAEKyneiRTQEQNIQHLNHSLSHKEQLLQE----FRELLQY 459
Cdd:TIGR02168  474 EQALDAAErelaqlqarlDSLERLQENLEGFSEGVKALLKNQ----SGLSGILGVLSELISVDEGYEAAieaaLGGRLQA 549
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   460 --RDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDlERLRDVLSS-------- 529
Cdd:TIGR02168  550 vvVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFD-PKLRKALSYllggvlvv 628
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   530 ---NEATMQSMES------------LLRAKGLEVEQLSTTCQNLQWLKEEMEtkfsrwqkEQESIIQQLQTSLHDRNKEV 594
Cdd:TIGR02168  629 ddlDNALELAKKLrpgyrivtldgdLVRPGGVITGGSAKTNSSILERRREIE--------ELEEKIEELEEKIAELEKAL 700
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   595 EDLSATLlcklgpgqSEIAEELCQRLQRKERMLQDlLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERN 674
Cdd:TIGR02168  701 AELRKEL--------EELEEELEQLRKELEELSRQ-ISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLE 771
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   675 SELQALRQYLGGRDSLMSQAP------------ISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTL 742
Cdd:TIGR02168  772 EAEEELAEAEAEIEELEAQIEqlkeelkalreaLDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELS 851
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   743 GDLdtvAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPE 822
Cdd:TIGR02168  852 EDI---ESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLE 928
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 525313637   823 DipAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQA 879
Cdd:TIGR02168  929 L--RLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKE 983
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
50-681 1.49e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 77.02  E-value: 1.49e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    50 ELKVEVESLKR---------ELQDKKQHLDKtWADVENLNSQNEAelRRQFEERQQETEHVYELLENKIQLLQEEsrlak 120
Cdd:TIGR02168  197 ELERQLKSLERqaekaerykELKAELRELEL-ALLVLRLEELREE--LEELQEELKEAEEELEELTAELQELEEK----- 268
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   121 neaarmaaLVEAEKEcNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRdkrieeLNQSLAAQERLVEQLSREKQQLL 200
Cdd:TIGR02168  269 --------LEELRLE-VSELEEEIEELQKELYALANEISRLEQQKQILRER------LANLERQLEELEAQLEELESKLD 333
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   201 HLLEEPTSMEVQpmTEELLKQQKLNSHEttitqqsvsdshLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQD 280
Cdd:TIGR02168  334 ELAEELAELEEK--LEELKEELESLEAE------------LEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN 399
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   281 GTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEgtspAQQQVALLDLQSALFCSQLEIQKLQR 360
Cdd:TIGR02168  400 NEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEEL----EELQEELERLEEALEELREELEEAEQ 475
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   361 VVRQKERQLADAKQCVQFVEA--AAHESEQQKEASWKHNQELRKALQQ-------------------LQEELQ-----NK 414
Cdd:TIGR02168  476 ALDAAERELAQLQARLDSLERlqENLEGFSEGVKALLKNQSGLSGILGvlselisvdegyeaaieaaLGGRLQavvveNL 555
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   415 SQQLRAWEAEKYNEI--------------------RTQEQNIQHLNHSLSHKEQLLQEFRELLQYR-------DNSD--- 464
Cdd:TIGR02168  556 NAAKKAIAFLKQNELgrvtflpldsikgteiqgndREILKNIEGFLGVAKDLVKFDPKLRKALSYLlggvlvvDDLDnal 635
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   465 ---KTLEANEML-------------------------------LEKLRQRI---HDKAVALERAIDEKFSALEEKEKELR 507
Cdd:TIGR02168  636 elaKKLRPGYRIvtldgdlvrpggvitggsaktnssilerrreIEELEEKIeelEEKIAELEKALAELRKELEELEEELE 715
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   508 QLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSL 587
Cdd:TIGR02168  716 QLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLK 795
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   588 HDRNKEVEDLSA-----TLLCKLGPGQSEIAEELCQRLQRKERMLQDlLSDRNKQVLEHEMEIQGLLQSVSTREQESQAA 662
Cdd:TIGR02168  796 EELKALREALDElraelTLLNEEAANLRERLESLERRIAATERRLED-LEEQIEELSEDIESLAAEIEELEELIEELESE 874
                          730
                   ....*....|....*....
gi 525313637   663 AEKLVQALMERNSELQALR 681
Cdd:TIGR02168  875 LEALLNERASLEEALALLR 893
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
288-857 1.25e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 73.82  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  288 ETLKsRERETEELYQVIEgqndtmAKLREMLHQSQLGQLHSsegtspAQQQVALLDLQSALfcSQLEIQKLQRVVRQKER 367
Cdd:COG1196   203 EPLE-RQAEKAERYRELK------EELKELEAELLLLKLRE------LEAELEELEAELEE--LEAELEELEAELAELEA 267
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  368 QLADAKQcvqfveaAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKE 447
Cdd:COG1196   268 ELEELRL-------ELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELE 340
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  448 QLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSAL---EEKEKELRQLRLAVRERDHDLERLR 524
Cdd:COG1196   341 ELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALraaAELAAQLEELEEAEEALLERLERLE 420
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  525 DVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCK 604
Cdd:COG1196   421 EELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE 500
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  605 ---LGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTR-EQESQAAAEKLVQALMER------- 673
Cdd:COG1196   501 adyEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEdDEVAAAAIEYLKAAKAGRatflpld 580
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  674 ----------NSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLG 743
Cdd:COG1196   581 kiraraalaaALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGG 660
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  744 DLDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAA-DMESLTRNIQIKEDLIKDLQMQLVDPE 822
Cdd:COG1196   661 SLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAeEERLEEELEEEALEEQLEAEREELLEE 740
                         570       580       590
                  ....*....|....*....|....*....|....*
gi 525313637  823 DIPAMERLTQEVLLLREKVASVESQGQEISGNRRQ 857
Cdd:COG1196   741 LLEEEELLEEEALEELPEPPDLEELERELERLERE 775
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
356-1038 3.50e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 3.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  356 QKLQRV---VRQKERQLA----DAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEkyne 428
Cdd:COG1196   186 ENLERLediLGELERQLEplerQAEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAE---- 261
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  429 IRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQ 508
Cdd:COG1196   262 LAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEE 341
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  509 LRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTtcQNLQWLKEEMETkfsrwQKEQESIIQQLQTSLH 588
Cdd:COG1196   342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE--ELLEALRAAAEL-----AAQLEELEEAEEALLE 414
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  589 DRNKEVEDLSATLLcklgpgQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQ 668
Cdd:COG1196   415 RLERLEEELEELEE------ALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE 488
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  669 ALMERNSELQALRQYLGGRDSLMSQAPISnQQAEVTPTGRLGKQTDQGsmqiPSRDDSTSLTAKEDVSIPRSTLGDLDTV 748
Cdd:COG1196   489 AAARLLLLLEAEADYEGFLEGVKAALLLA-GLRGLAGAVAVLIGVEAA----YEAALEAALAAALQNIVVEDDEVAAAAI 563
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  749 AGLEKELSNAKEELELMAKKERESQMELSALQSMMA--VQEEELQVQAADMESLTRNIQIKEDLIKDlqmqlvDPEDIPA 826
Cdd:COG1196   564 EYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAavDLVASDLREADARYYVLGDTLLGRTLVAA------RLEAALR 637
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  827 MERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSslvkfhahpESSERDRTLQVE 906
Cdd:COG1196   638 RAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELE---------EALLAEEEEERE 708
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  907 LEGAQVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAhhshqqlvkvalekslatvetqnp 986
Cdd:COG1196   709 LAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEE------------------------ 764
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|..
gi 525313637  987 sfsppspmggdsnrclqeemlhlraefhqhleekrkAEEELKELKAQIEEAG 1038
Cdd:COG1196   765 ------------------------------------LERELERLEREIEALG 780
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
399-669 4.27e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 68.94  E-value: 4.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   399 ELRKALQQLQEE---------LQNKSQQLRAWEaeKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDnsdKTLEA 469
Cdd:TIGR02169  195 EKRQQLERLRRErekaeryqaLLKEKREYEGYE--LLKEKEALERQKEAIERQLASLEEELEKLTEEISELE---KRLEE 269
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   470 NEMLLEKLRQRIHDKAVALERAIDEKfsaLEEKEKELRQLRLAVRERDHDLERLrdvlssnEATMQSMESLLRAKGLEVE 549
Cdd:TIGR02169  270 IEQLLEELNKKIKDLGEEEQLRVKEK---IGELEAEIASLERSIAEKERELEDA-------EERLAKLEAEIDKLLAEIE 339
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   550 QLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQtSLHDRNKEVEDLSATLLCKLGPGQSEIAEelcqrLQRKERMLQD 629
Cdd:TIGR02169  340 ELEREIEEERKRRDKLTEEYAELKEELEDLRAELE-EVDKEFAETRDELKDYREKLEKLKREINE-----LKRELDRLQE 413
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 525313637   630 LLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQA 669
Cdd:TIGR02169  414 ELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQ 453
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
12-510 1.24e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 66.97  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    12 LNDLKKENFSLKLRIYFLEERMQQ--KYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEaELRR 89
Cdd:TIGR04523  189 IDKIKNKLLKLELLLSNLKKKIQKnkSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQN-KIKK 267
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    90 QFEERQQETEHVYELLENKIQLLQEesrlAKNEaarmaaLVEAEKECNLELSEKLKGVTKNWEDvpgdqvKPDQYTEALA 169
Cdd:TIGR04523  268 QLSEKQKELEQNNKKIKELEKQLNQ----LKSE------ISDLNNQKEQDWNKELKSELKNQEK------KLEEIQNQIS 331
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   170 QRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSmEVQPMTEEllKQQKLNSHETTITQQSvsdshlaELQEKIQ 249
Cdd:TIGR04523  332 QNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQN-EIEKLKKE--NQSYKQEIKNLESQIN-------DLESKIQ 401
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   250 QTEATNKILQEKlnemsyelkcaqessqkqdgtIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSS 329
Cdd:TIGR04523  402 NQEKLNQQKDEQ---------------------IKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLD 460
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   330 EGTSPAQQQVALLdlqsalfcsQLEIQKLQRVVRQKERQLAdakqcvqfveaaahESEQQKEASWKHNQELR---KALQQ 406
Cdd:TIGR04523  461 NTRESLETQLKVL---------SRSINKIKQNLEQKQKELK--------------SKEKELKKLNEEKKELEekvKDLTK 517
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSH---KEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRiHD 483
Cdd:TIGR04523  518 KISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKenlEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQK-EK 596
                          490       500
                   ....*....|....*....|....*..
gi 525313637   484 KAVALERAIDEKFSALEEKEKELRQLR 510
Cdd:TIGR04523  597 EKKDLIKEIEEKEKKISSLEKELEKAK 623
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
120-527 3.25e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.85  E-value: 3.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   120 KNEAARMAALVEAEKECNLELSEKLKGVtknwedvpgdQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQL 199
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAEL----------RKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   200 LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQsvsDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQ 279
Cdd:TIGR02168  746 EERIAQLSKELTELEAEIEELEERLEEAEEELAEA---EAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANL 822
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   280 DGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREmlhqsqlgqlhssegtspaqqqvALLDLQSALFCSQLEIQKLQ 359
Cdd:TIGR02168  823 RERLESLERRIAATERRLEDLEEQIEELSEDIESLAA-----------------------EIEELEELIEELESELEALL 879
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   360 RVVRQKERQLADAKqcvqfvEAAAHESEQQKEASwKHNQELRKALQQLQEELqnksqqlraweAEKYNEIRTQEQNIQHL 439
Cdd:TIGR02168  880 NERASLEEALALLR------SELEELSEELRELE-SKRSELRRELEELREKL-----------AQLELRLEGLEVRIDNL 941
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   440 NHSLSHKEQLLQEFrellqyrdnsdktLEANEMLLEKLRQRIHDKAVALERAIDE----KFSALEEKEkELRQLRLAVRE 515
Cdd:TIGR02168  942 QERLSEEYSLTLEE-------------AEALENKIEDDEEEARRRLKRLENKIKElgpvNLAAIEEYE-ELKERYDFLTA 1007
                          410
                   ....*....|..
gi 525313637   516 RDHDLERLRDVL 527
Cdd:TIGR02168 1008 QKEDLTEAKETL 1019
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
29-693 6.15e-10

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 64.99  E-value: 6.15e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    29 LEERMQQKYEAsrEDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEA-ELRRQFEERQQETEHVYELLEN 107
Cdd:TIGR00618  231 LREALQQTQQS--HAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERiNRARKAAPLAAHIKAVTQIEQQ 308
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   108 KIQLLQE-ESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVkpDQYTEALAQRDKRIEELNQSLAAQE 186
Cdd:TIGR00618  309 AQRIHTElQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAH--EVATSIREISCQQHTLTQHIHTLQQ 386
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   187 R---LVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQE--- 260
Cdd:TIGR00618  387 QkttLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQEsaq 466
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   261 KLNEMSYELKCAQESSQKQDGT----------IQNLKETLKSRERETE-ELYQVIEGQNDTMAKLREMLHQSQLGQlhsS 329
Cdd:TIGR00618  467 SLKEREQQLQTKEQIHLQETRKkavvlarlleLQEEPCPLCGSCIHPNpARQDIDNPGPLTRRMQRGEQTYAQLET---S 543
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   330 EGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQE 409
Cdd:TIGR00618  544 EEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQP 623
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   410 ELQNksQQLRAweaekyneirTQEQNIQHLNHSLSHKEQLLQEfrelLQYRDNSDKTLEANEMLLEKL--RQRIHDKAVA 487
Cdd:TIGR00618  624 EQDL--QDVRL----------HLQQCSQELALKLTALHALQLT----LTQERVREHALSIRVLPKELLasRQLALQKMQS 687
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   488 LERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTcqNLQWLKEEMET 567
Cdd:TIGR00618  688 EKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQART--VLKARTEAHFN 765
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   568 KFSRWQKEQESI--IQQLQTSLHDRNKEVEDLSATLLCKLgpgqSEIAEELCQRLQrkERMLQDLLSDRNKQVLEHEMEI 645
Cdd:TIGR00618  766 NNEEVTAALQTGaeLSHLAAEIQFFNRLREEDTHLLKTLE----AEIGQEIPSDED--ILNLQCETLVQEEEQFLSRLEE 839
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*...
gi 525313637   646 QGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693
Cdd:TIGR00618  840 KSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQ 887
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
395-1131 7.16e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 64.61  E-value: 7.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   395 KHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQ---------------------HLNHSLSHKEQLLQEF 453
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKaleyyqlkekleleeeyllylDYLKLNEERIDLLQEL 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   454 RELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEAT 533
Cdd:pfam02463  246 LRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKK 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   534 MQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHD----RNKEVEDLSATLLCKLGPGQ 609
Cdd:pfam02463  326 AEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLeserLSSAAKLKEEELELKSEEEK 405
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   610 SEiaeelcQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQ---ALRQYLGG 686
Cdd:pfam02463  406 EA------QLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKkseDLLKETQL 479
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   687 RDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEdvsiPRSTLGDLDTVAGLEKELSNAKEELELMA 766
Cdd:pfam02463  480 VKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIIS----AHGRLGDLGVAVENYKVAISTAVIVEVSA 555
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   767 KK------ERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQmQLVDPEDIPAMERLTQEVLLLREK 840
Cdd:pfam02463  556 TAdeveerQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDK-ATLEADEDDKRAKVVEGILKDTEL 634
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   841 VASVESQGQEISGNRRQQlllMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEV 920
Cdd:pfam02463  635 TKLKESAKAKESGLRKGV---SLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEE 711
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   921 LGRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNpsfsppSPMGGDSNR 1000
Cdd:pfam02463  712 LKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKEL------AEEREKTEK 785
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1001 CLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFSSVSHIRNTMLSlcLENAELKEQMGEAMSDGWEIEEDKEKG 1080
Cdd:pfam02463  786 LKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELE--ELALELKEEQKLEKLAEEELERLEEEI 863
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|.
gi 525313637  1081 EVMVETVVTKEGLSESSLQAEFRKLQGKLKNAHNIinlLKEQLVLSSKEGN 1131
Cdd:pfam02463  864 TKEELLQELLLKEEELEEQKLKDELESKEEKEKEE---KKELEEESQKLNL 911
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
17-838 2.75e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 62.83  E-value: 2.75e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    17 KENFSLKLRIYFLEER-MQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTwADVENLNSQNEAELRRQFEERQ 95
Cdd:pfam15921   73 KEHIERVLEEYSHQVKdLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAM-ADIRRRESQSQEDLRNQLQNTV 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    96 QETEHVYELLENKI-----QLLQEESRLAKNEAARM---AALVEAEKECNLELSEKLKGVTKNWEDVpGDQVkpdqyTEA 167
Cdd:pfam15921  152 HELEAAKCLKEDMLedsntQIEQLRKMMLSHEGVLQeirSILVDFEEASGKKIYEHDSMSTMHFRSL-GSAI-----SKI 225
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   168 LAQRDKRIEELNQSLAAQERLVEQLSREKQQLLhlleeptsmevqpmteELLKQQKLNSHETTITQQSVsdsHLAELQEK 247
Cdd:pfam15921  226 LRELDTEISYLKGRIFPVEDQLEALKSESQNKI----------------ELLLQQHQDRIEQLISEHEV---EITGLTEK 286
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   248 IQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQviegqndtmAKLREMLHQSQLGQLH 327
Cdd:pfam15921  287 ASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYE---------DKIEELEKQLVLANSE 357
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   328 SSEGTSPAQQqvalLDLQSALFCSQLeiQKLQRVVRQKERQLAdakqcvqfveaaaHESEQQKEAsWKHN-------QEL 400
Cdd:pfam15921  358 LTEARTERDQ----FSQESGNLDDQL--QKLLADLHKREKELS-------------LEKEQNKRL-WDRDtgnsitiDHL 417
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   401 RKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 480
Cdd:pfam15921  418 RRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERT 497
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   481 IHDKAVALEraidEKFSALEEKEKELRQLRLAVRERDHDLERLR---DVLSSNEATMQSMESLLRAKGLEVEQLSTTCQN 557
Cdd:pfam15921  498 VSDLTASLQ----EKERAIEATNAEITKLRSRVDLKLQELQHLKnegDHLRNVQTECEALKLQMAEKDKVIEILRQQIEN 573
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   558 LQWLKEEMETKFSRWQKEQesiiQQLQTSLHDRNKEVEDLSatLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQ 637
Cdd:pfam15921  574 MTQLVGQHGRTAGAMQVEK----AQLEKEINDRRLELQEFK--ILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRA 647
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   638 VLEHEMEIQGLLQSVSTREQESQAAAEKLvqALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTGRLGKQTDQGS 717
Cdd:pfam15921  648 VKDIKQERDQLLNEVKTSRNELNSLSEDY--EVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHA 725
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   718 MQIpsrddstSLTAKEDVSIPRSTLGDLDT-VAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAAD 796
Cdd:pfam15921  726 MKV-------AMGMQKQITAKRGQIDALQSkIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQ 798
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|..
gi 525313637   797 MESLTRNIQIKEDLIKDLQMQLVDPEDIpaMERLTQEVLLLR 838
Cdd:pfam15921  799 ERRLKEKVANMEVALDKASLQFAECQDI--IQRQEQESVRLK 838
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1-579 3.70e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 62.05  E-value: 3.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637     1 MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQK---YEASREDIYKRNIELKVEVESLKRELQD-----KKQHLDKT 72
Cdd:pfam05483   76 LSRLYSKLYKEAEKIKKWKVSIEAELKQKENKLQENrkiIEAQRKAIQELQFENEKVSLKLEEEIQEnkdliKENNATRH 155
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    73 WADVENLNSQNEAELRRQFEERQQETEHVYELLENKIqllqeESRLAKNEAARMAAlveaeKECNLELSEKLKgvtknwE 152
Cdd:pfam05483  156 LCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNI-----EKMILAFEELRVQA-----ENARLEMHFKLK------E 219
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   153 DVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLS---REKQQLLHLLEEPTSMEVQPMTEELLKQQKLNshet 229
Cdd:pfam05483  220 DHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTfllEESRDKANQLEEKTKLQDENLKELIEKKDHLT---- 295
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   230 titqqsvsdSHLAELQEKIQQTEATNKILQEKLN-------EMSYELKCAQESSQKQDGT----IQNLKETLKSRERETE 298
Cdd:pfam05483  296 ---------KELEDIKMSLQRSMSTQKALEEDLQiatkticQLTEEKEAQMEELNKAKAAhsfvVTEFEATTCSLEELLR 366
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   299 ELYQVIEGQNDTMAKLREMLhqsqlgQLHSSEgtspaqqqvaLLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQcvqf 378
Cdd:pfam05483  367 TEQQRLEKNEDQLKIITMEL------QKKSSE----------LEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQ---- 426
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   379 VEAAAHESEQQKeaswkhnQELRKALQQLQEELQNKSQQLRA------WEAEKYNEIRTQEQNIQHLNHSL-SHKEQLLQ 451
Cdd:pfam05483  427 FEKIAEELKGKE-------QELIFLLQAREKEIHDLEIQLTAiktseeHYLKEVEDLKTELEKEKLKNIELtAHCDKLLL 499
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   452 EFRELLQyrDNSDKTLEanemlLEKLRQRIHDKAVALERAIdEKFSALEEKEKELRQLRLAVRER-DHDLERLRDVLSSN 530
Cdd:pfam05483  500 ENKELTQ--EASDMTLE-----LKKHQEDIINCKKQEERML-KQIENLEEKEMNLRDELESVREEfIQKGDEVKCKLDKS 571
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 525313637   531 EATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESI 579
Cdd:pfam05483  572 EENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKAL 620
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
50-602 4.32e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 61.96  E-value: 4.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    50 ELKVEVESLKRELQDKKQHLDKTWADVENLNSQ----------NEAELRRQFEERQQETEHVYELLeNKIQLLQEESRLA 119
Cdd:TIGR04523   79 ILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEikndkeqknkLEVELNKLEKQKKENKKNIDKFL-TEIKKKEKELEKL 157
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   120 KNEAARMAALVEA-EKECNLELSEKLKgVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQ 198
Cdd:TIGR04523  158 NNKYNDLKKQKEElENELNLLEKEKLN-IQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEK 236
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   199 LLHLLEEptsmevqpmteellKQQKLNSHETTITQQSVSDSH-LAELQEKIQQTEATNKILQEKLNEMS-YELKCAQESS 276
Cdd:TIGR04523  237 KQQEINE--------------KTTEISNTQTQLNQLKDEQNKiKKQLSEKQKELEQNNKKIKELEKQLNqLKSEISDLNN 302
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   277 QKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREmlhqsQLGQLHSSegtspaqqqvaLLDLQSALFCSQLEIQ 356
Cdd:TIGR04523  303 QKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNE-----QISQLKKE-----------LTNSESENSEKQRELE 366
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   357 KLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQ---LRAWEAEKYNEIRTQE 433
Cdd:TIGR04523  367 EKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEierLKETIIKNNSEIKDLT 446
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   434 QNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANemlLEKLRQRIHDKAVALERAIDEKfSALEEKEKELRQLRLAV 513
Cdd:TIGR04523  447 NQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQN---LEQKQKELKSKEKELKKLNEEK-KELEEKVKDLTKKISSL 522
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   514 RERDHDLE----RLRDVLSSNEATMQSMESLLRAKGLEvEQLSTTCQNLQWLKEEmETKFSRWQKEQESIIQQLQTSLHD 589
Cdd:TIGR04523  523 KEKIEKLEsekkEKESKISDLEDELNKDDFELKKENLE-KEIDEKNKEIEELKQT-QKSLKKKQEEKQELIDQKEKEKKD 600
                          570
                   ....*....|...
gi 525313637   590 RNKEVEDLSATLL 602
Cdd:TIGR04523  601 LIKEIEEKEKKIS 613
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
210-524 9.29e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.24  E-value: 9.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   210 EVQPMTEELLKQQKLnsHETTITQQSVSDSHLAELQEKIQQteatnkiLQEKLNEMSYELKCAQESSQKQDGTIQNLKET 289
Cdd:TIGR02169  675 ELQRLRERLEGLKRE--LSSLQSELRRIENRLDELSQELSD-------ASRKIGEIEKEIEQLEQEEEKLKERLEELEED 745
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   290 LKSRERETEELYQVIEGQNDTMAKLREMLH--QSQLGQLHSSEGTSPAQQQVALL---------------DLQSALFCSQ 352
Cdd:TIGR02169  746 LSSLEQEIENVKSELKELEARIEELEEDLHklEEALNDLEARLSHSRIPEIQAELskleeevsriearlrEIEQKLNRLT 825
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   353 LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAekynEIRTQ 432
Cdd:TIGR02169  826 LEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEA----QLREL 901
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   433 EQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE----------ANEMLLEKLRQRIHDKAVALE-------RAIDE- 494
Cdd:TIGR02169  902 ERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEdpkgedeeipEEELSLEDVQAELQRVEEEIRalepvnmLAIQEy 981
                          330       340       350
                   ....*....|....*....|....*....|....*
gi 525313637   495 -----KFSALEEKEKELRQLRLAVRERDHDLERLR 524
Cdd:TIGR02169  982 eevlkRLDELKEKRAKLEEERKAILERIEEYEKKK 1016
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
92-1036 1.86e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 60.08  E-value: 1.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    92 EERQQETEHVYELLENKIQLLQEEsrlaKNEAARMAALVEAEKEcnLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQR 171
Cdd:TIGR02169  183 EENIERLDLIIDEKRQQLERLRRE----REKAERYQALLKEKRE--YEGYELLKEKEALERQKEAIERQLASLEEELEKL 256
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   172 DKRIEELNQSLAAQERLVEQLSREkqqllhlleeptsmeVQPMTEELLKQQKLNSHETTITQQSVSDShLAELQEKIQQT 251
Cdd:TIGR02169  257 TEEISELEKRLEEIEQLLEELNKK---------------IKDLGEEEQLRVKEKIGELEAEIASLERS-IAEKERELEDA 320
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   252 EATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLhqsqlgqlhsseg 331
Cdd:TIGR02169  321 EERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDEL------------- 387
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   332 tspAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEaswkhnqELRKALQQLQEEL 411
Cdd:TIGR02169  388 ---KDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKE-------DKALEIKKQEWKL 457
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   412 QNKSQQLRAWEAEKYNeirtQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERa 491
Cdd:TIGR02169  458 EQLAADLSKYEQELYD----LKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGS- 532
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   492 IDEKFSALEEKEKELRqLRLAVRERDHDLERLRDVLSSNEATMQSMESL--LRAKGLEVEQLSTT-----CQNLQWLKEE 564
Cdd:TIGR02169  533 VGERYATAIEVAAGNR-LNNVVVEDDAVAKEAIELLKRRKAGRATFLPLnkMRDERRDLSILSEDgvigfAVDLVEFDPK 611
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   565 METKFsrWQKEQESIIqqlqtslhdrnkeVEDLsatllcklgpgqseiaeELCQRLQRKERMLQ---DLLSDRNKQVLEH 641
Cdd:TIGR02169  612 YEPAF--KYVFGDTLV-------------VEDI-----------------EAARRLMGKYRMVTlegELFEKSGAMTGGS 659
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   642 EMEIQGLLQSVSTREQESQAAAEklvqaLMERNSELQALRQYLGGRDSLMSQAPISNQQAEvtptgrlgkqtdqgsmqip 721
Cdd:TIGR02169  660 RAPRGGILFSRSEPAELQRLRER-----LEGLKRELSSLQSELRRIENRLDELSQELSDAS------------------- 715
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   722 srddstsltakedvsiprstlgdldtvagleKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLT 801
Cdd:TIGR02169  716 -------------------------------RKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELE 764
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   802 RNIQIKEDLIKDLQMQLVDPEDIPAMER---LTQEVLLLREKVASVESQGQEISG--NRRQQLLLMLEGLVDERSRLNEA 876
Cdd:TIGR02169  765 ARIEELEEDLHKLEEALNDLEARLSHSRipeIQAELSKLEEEVSRIEARLREIEQklNRLTLEKEYLEKEIQELQEQRID 844
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   877 LQAERqlysslVKFHAHPESSE-RDRTLQVELEGAQV----LRSRLEEVLGRSLERLNRLETLaaiggaaagddtEDTST 951
Cdd:TIGR02169  845 LKEQI------KSIEKEIENLNgKKEELEEELEELEAalrdLESRLGDLKKERDELEAQLREL------------ERKIE 906
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   952 EFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPSFSPPSPMGGDSnRCLQEEMLHLRAEFH----------QHLEEKR 1021
Cdd:TIGR02169  907 ELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSL-EDVQAELQRVEEEIRalepvnmlaiQEYEEVL 985
                          970
                   ....*....|....*
gi 525313637  1022 KAEEELKELKAQIEE 1036
Cdd:TIGR02169  986 KRLDELKEKRAKLEE 1000
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
31-554 2.10e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 59.67  E-value: 2.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   31 ERMQQKYEASREDIyKRNIELKVEVESLKReLQDKKQHLDKTWADVENLNSQNE-AELRRQ--------FEERQQETEHv 101
Cdd:PRK02224  179 ERVLSDQRGSLDQL-KAQIEEKEEKDLHER-LNGLESELAELDEEIERYEEQREqARETRDeadevleeHEERREELET- 255
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  102 yelLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEE-LNQ 180
Cdd:PRK02224  256 ---LEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDrLEE 332
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  181 SLAAQERLVEQLSREKQQLLHLLEEPTsmEVQPMTEELlkQQKLNSHETTITQQSvsdSHLAELQEKIQQTEATNKILQE 260
Cdd:PRK02224  333 CRVAAQAHNEEAESLREDADDLEERAE--ELREEAAEL--ESELEEAREAVEDRR---EEIEELEEEIEELRERFGDAPV 405
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  261 KLNEMSYELKCAQESSQKQDGTIQNLKETLKS---RERETEELYQ------------------VIEGQNDTMAKLREMLH 319
Cdd:PRK02224  406 DLGNAEDFLEELREERDELREREAELEATLRTareRVEEAEALLEagkcpecgqpvegsphveTIEEDRERVEELEAELE 485
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  320 QSQLGQ------LHSSEGTSPAQQQVALLDLQSALFCSQLEIQKlqRVVRQKERQLADAKQCVQFVEAAAHESEQQKEAS 393
Cdd:PRK02224  486 DLEEEVeeveerLERAEDLVEAEDRIERLEERREDLEELIAERR--ETIEEKRERAEELRERAAELEAEAEEKREAAAEA 563
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  394 WKHNQELRKALQQLQEELQNKSQQLRAWE--AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEA-- 469
Cdd:PRK02224  564 EEEAEEAREEVAELNSKLAELKERIESLEriRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAef 643
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  470 NEMLLEKLRQRiHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRakglEVE 549
Cdd:PRK02224  644 DEARIEEARED-KERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVEALEALYD----EAE 718

                  ....*
gi 525313637  550 QLSTT 554
Cdd:PRK02224  719 ELESM 723
Olduvai pfam06758
Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the ...
1552-1621 4.98e-08

Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the Olduvai domain. It is found highly duplicated in the human lineage.


Pssm-ID: 429104 [Multi-domain]  Cd Length: 68  Bit Score: 51.65  E-value: 4.98e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1552 DHKSEKDQaglEPLALRLSRELQEKEKViEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACS 1621
Cdd:pfam06758    1 DEEEEEDQ---EPLAPRLSRELPEVEEQ-EVPQDSLDECYLTPSVLPDLSDSYQPYRSTIFSFEEQQVSS 66
PTZ00121 PTZ00121
MAEBL; Provisional
30-516 1.19e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.46  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   30 EERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLE-NK 108
Cdd:PTZ00121 1313 EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEkKK 1392
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  109 IQLLQEESRLAKNEAARMAALVEAEKECNlELSEKLKGVTKNWE-DVPGDQVKPDQYTEALAQRDKRIEELNQSlAAQER 187
Cdd:PTZ00121 1393 ADEAKKKAEEDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEaKKKAEEAKKADEAKKKAEEAKKAEEAKKK-AEEAK 1470
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  188 LVEQLSREKQQLLHLLE-EPTSMEVQPMTEELLK--QQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNE 264
Cdd:PTZ00121 1471 KADEAKKKAEEAKKADEaKKKAEEAKKKADEAKKaaEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADE 1550
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  265 M--SYELKCAQESSQKQDGtiQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALL 342
Cdd:PTZ00121 1551 LkkAEELKKAEEKKKAEEA--KKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKA 1628
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  343 DlQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEA--SWKHNQELRKALQQL--QEELQNKSQQL 418
Cdd:PTZ00121 1629 E-EEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAeeAKKAEEDEKKAAEALkkEAEEAKKAEEL 1707
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  419 RAWEAEkynEIRTQEQNIQHLNHSLSHKEQLLQEFREllqyRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSA 498
Cdd:PTZ00121 1708 KKKEAE---EKKKAEELKKAEEENKIKAEEAKKEAEE----DKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAV 1780
                         490
                  ....*....|....*...
gi 525313637  499 LEEKEKELRQLRLAVRER 516
Cdd:PTZ00121 1781 IEEELDEEDEKRRMEVDK 1798
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
10-582 1.54e-07

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 57.04  E-value: 1.54e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    10 QHLNDLKKENFSLKLRIYFLEERMQQK---YEASREDIYKRNIELKVEVESLKrELQDKKQHLDKTWADVEnLNSQNEAE 86
Cdd:pfam05483  233 KEINDKEKQVSLLLIQITEKENKMKDLtflLEESRDKANQLEEKTKLQDENLK-ELIEKKDHLTKELEDIK-MSLQRSMS 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    87 LRRQFEERQQ-ETEHVYELLENKIQLLQEesrlaKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKpdQYT 165
Cdd:pfam05483  311 TQKALEEDLQiATKTICQLTEEKEAQMEE-----LNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLK--IIT 383
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   166 EALAQRDKRIEELNQSLAAQERLVEQLSR---EKQQLLHLLE--EPTSMEVQPMTEELL-----KQQKLNSHETTITQQS 235
Cdd:pfam05483  384 MELQKKSSELEEMTKFKNNKEVELEELKKilaEDEKLLDEKKqfEKIAEELKGKEQELIfllqaREKEIHDLEIQLTAIK 463
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   236 VSDSH----LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTM 311
Cdd:pfam05483  464 TSEEHylkeVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKE 543
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   312 AKLREMLHQSQLGQLHSSEGTspaqqqvalldlqsalfcsQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKE 391
Cdd:pfam05483  544 MNLRDELESVREEFIQKGDEV-------------------KCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIE 604
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   392 ASWKHNQELRKALQQLQEELQNKSQQLRAWEAeKYNEIRTQEQNIQhlnhslshkeqllQEFRELLqyrDNSDKTLEANE 471
Cdd:pfam05483  605 NKNKNIEELHQENKALKKKGSAENKQLNAYEI-KVNKLELELASAK-------------QKFEEII---DNYQKEIEDKK 667
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   472 MLLEKLRQRIH------DKAVALERAIDEK-------FSALEEKEKElrQLRLAVRERDHDLERLRDVLSSNEATMQSME 538
Cdd:pfam05483  668 ISEEKLLEEVEkakaiaDEAVKLQKEIDKRcqhkiaeMVALMEKHKH--QYDKIIEERDSELGLYKNKEQEQSSAKAALE 745
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....
gi 525313637   539 SLLraKGLEVEQLSTTCQnLQWLKEEMEtKFSRWQKEQESIIQQ 582
Cdd:pfam05483  746 IEL--SNIKAELLSLKKQ-LEIEKEEKE-KLKMEAKENTAILKD 785
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
58-559 1.56e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 56.70  E-value: 1.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   58 LKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECN 137
Cdd:COG4717    47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQ 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  138 L-ELSEKLKGVTKNWEDVpgdqvkPDQYtEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTE 216
Cdd:COG4717   127 LlPLYQELEALEAELAEL------PERL-EELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAE 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  217 ELLKQQKLnshettitqqsvsdshLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKET----LKS 292
Cdd:COG4717   200 ELEELQQR----------------LAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAallaLLG 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  293 RERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSS-EGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVrQKERQLAD 371
Cdd:COG4717   264 LGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLgKEAEELQALPALEELEEEELEELLAALGLPPDL-SPEELLEL 342
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  372 AKQCVQFVEAAAHESEQQKEASWKHNQELRKALqqLQEELQNKSQQLRAWeAEKYNEIRTQEQNIQHLNHSLshkEQLLQ 451
Cdd:COG4717   343 LDRIEELQELLREAEELEEELQLEELEQEIAAL--LAEAGVEDEEELRAA-LEQAEEYQELKEELEELEEQL---EELLG 416
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  452 EFRELLQYRDnsdktleanemlLEKLRQRIHDKAVALErAIDEKFSALEEKEKELRQlRLAVRERDHDLERLRDVLSSNE 531
Cdd:COG4717   417 ELEELLEALD------------EEELEEELEELEEELE-ELEEELEELREELAELEA-ELEQLEEDGELAELLQELEELK 482
                         490       500
                  ....*....|....*....|....*...
gi 525313637  532 ATMQSMESLLRAKGLEVEQLSTTCQNLQ 559
Cdd:COG4717   483 AELRELAEEWAALKLALELLEEAREEYR 510
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
290-791 2.53e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.93  E-value: 2.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  290 LKSRERETEELYQVIEGQND-----TMAKLREMLHQS---QLGQLHSSEGTSPAQQQVALLDLQSAL---FCSQLEIQKL 358
Cdd:COG4717    14 FRDRTIEFSPGLNVIYGPNEagkstLLAFIRAMLLERlekEADELFKPQGRKPELNLKELKELEEELkeaEEKEEEYAEL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  359 QRVVRQKERQLADAKQcvqfvEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEaEKYNEIRTQEQNIQH 438
Cdd:COG4717    94 QEELEELEEELEELEA-----ELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELE-ERLEELRELEEELEE 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  439 LNHSLSHKEQLLQEfrellQYRDNSDKTLEANEMLLEKLrQRIHDKAVALERAIDEKFSALEEKEKELRQLRlAVRERDH 518
Cdd:COG4717   168 LEAELAELQEELEE-----LLEQLSLATEEELQDLAEEL-EELQQRLAELEEELEEAQEELEELEEELEQLE-NELEAAA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  519 DLERLRDVLSSNEATmqSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEvEDLS 598
Cdd:COG4717   241 LEERLKEARLLLLIA--AALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPAL-EELE 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  599 ATLLCKL-------GPGQSEIAEELCQRLQRKERMLQDLLSDRNK-QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQAL 670
Cdd:COG4717   318 EEELEELlaalglpPDLSPEELLELLDRIEELQELLREAEELEEElQLEELEQEIAALLAEAGVEDEEELRAALEQAEEY 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  671 MERNSELQALRQYLGgrdslmSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTS--LTAKEDVSIPRSTLGDLDTV 748
Cdd:COG4717   398 QELKEELEELEEQLE------ELLGELEELLEALDEEELEEELEELEEELEELEEELEelREELAELEAELEQLEEDGEL 471
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 525313637  749 AGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQ 791
Cdd:COG4717   472 AELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERL 514
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
5-579 2.66e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 56.23  E-value: 2.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    5 YRTLSQHLNDLKKEnfsLKLRIYFLEermqqKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLnsqne 84
Cdd:PRK03918  160 YENAYKNLGEVIKE---IKRRIERLE-----KFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKL----- 226
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   85 aelrrqfEERQQETEHVYELLEN-KIQLLQEESRLAKNEaarmAALVEAEKECNlELSEKLKGVTKNWEDVPGDQVKPDQ 163
Cdd:PRK03918  227 -------EKEVKELEELKEEIEElEKELESLEGSKRKLE----EKIRELEERIE-ELKKEIEELEEKVKELKELKEKAEE 294
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  164 YTEALAQRDKRIEELNQSlaaqERLVEQLSREKQQLLHLLEEPTSMEVQpmTEELLKQQKLNSHETTITQQSVSDSHLA- 242
Cdd:PRK03918  295 YIKLSEFYEEYLDELREI----EKRLSRLEEEINGIEERIKELEEKEER--LEELKKKLKELEKRLEELEERHELYEEAk 368
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  243 ELQEKIQQTEATNKILQ-EKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREML--- 318
Cdd:PRK03918  369 AKKEELERLKKRLTGLTpEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELtee 448
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  319 HQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKlqrvVRQKERQLADAKQCVQFVEAAAHESE----QQKEASW 394
Cdd:PRK03918  449 HRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEK----VLKKESELIKLKELAEQLKELEEKLKkynlEELEKKA 524
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  395 KHNQELRKALQQLQEELQN------KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHK-----EQLLQEFRELLQYRD-- 461
Cdd:PRK03918  525 EEYEKLKEKLIKLKGEIKSlkkeleKLEELKKKLAELEKKLDELEEELAELLKELEELgfesvEELEERLKELEPFYNey 604
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  462 ----NSDKTLEANEMLLEKLRqrihDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHdlERLRDVLSSNEATMQSM 537
Cdd:PRK03918  605 lelkDAEKELEREEKELKKLE----EELDKAFEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGL 678
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 525313637  538 ESllRAKGLEvEQLSTTCQNLQWLKEEMEtKFSRWQKEQESI 579
Cdd:PRK03918  679 RA--ELEELE-KRREEIKKTLEKLKEELE-EREKAKKELEKL 716
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
268-1037 3.21e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 56.23  E-value: 3.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   268 ELKCAQESSQKQDGTIQNLKETLK--SRERETEELYQviegqnDTMAKLREMlhqsqlgqlhssEGTSPAQQQVALLDLQ 345
Cdd:TIGR02169  178 ELEEVEENIERLDLIIDEKRQQLErlRREREKAERYQ------ALLKEKREY------------EGYELLKEKEALERQK 239
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   346 SALfcsQLEIQKLQRVVRQKERQLAD-AKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAE 424
Cdd:TIGR02169  240 EAI---ERQLASLEEELEKLTEEISElEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERE 316
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   425 KYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEK 504
Cdd:TIGR02169  317 LEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEK 396
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   505 ----------ELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSttcQNLQWLKEEMETKFSRWQK 574
Cdd:TIGR02169  397 lkreinelkrELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQE---WKLEQLAADLSKYEQELYD 473
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   575 EQESiIQQLQTSLHDRNKEVEDLSATL--LCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSV 652
Cdd:TIGR02169  474 LKEE-YDRVEKELSKLQRELAEAEAQAraSEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGNRLNNV 552
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   653 STreqESQAAAEKLVQALMERNselqalrqylGGRdslMSQAPISNQQAEVTPTGRLGKQTDQG-SMQIPSRDD------ 725
Cdd:TIGR02169  553 VV---EDDAVAKEAIELLKRRK----------AGR---ATFLPLNKMRDERRDLSILSEDGVIGfAVDLVEFDPkyepaf 616
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   726 -----STSLTakEDVSIPRSTLGDLDTVAgLEKEL----------SNAKEELELMAKKERESQMELSA-LQSMmavqEEE 789
Cdd:TIGR02169  617 kyvfgDTLVV--EDIEAARRLMGKYRMVT-LEGELfeksgamtggSRAPRGGILFSRSEPAELQRLRErLEGL----KRE 689
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   790 LQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDipAMERLTQEVLLLREKVASVESQGQEISgNRRQQLLLMLEGLVDE 869
Cdd:TIGR02169  690 LSSLQSELRRIENRLDELSQELSDASRKIGEIEK--EIEQLEQEEEKLKERLEELEEDLSSLE-QEIENVKSELKELEAR 766
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   870 RSRLNEALQAERQlysSLVKFHAHPeSSERDRTLQVELEGAQVLRSRLEEVLgRSLERLNRLETLAAIGGAAAGDDTEDT 949
Cdd:TIGR02169  767 IEELEEDLHKLEE---ALNDLEARL-SHSRIPEIQAELSKLEEEVSRIEARL-REIEQKLNRLTLEKEYLEKEIQELQEQ 841
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   950 STEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQnpsfsppspmggdsNRCLQEEMLHLRAEFHQHLEEKRKAEEELKE 1029
Cdd:TIGR02169  842 RIDLKEQIKSIEKEIENLNGKKEELEEELEELEAA--------------LRDLESRLGDLKKERDELEAQLRELERKIEE 907

                   ....*...
gi 525313637  1030 LKAQIEEA 1037
Cdd:TIGR02169  908 LEAQIEKK 915
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
29-829 4.11e-07

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 55.82  E-value: 4.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    29 LEERmQQKYEASREDIYKRNIELKvEVESLKRELQDKKQHLDKTWADV-----ENLNS--QNEAELRRQFEERQQETEHV 101
Cdd:TIGR00606  250 LKNR-LKEIEHNLSKIMKLDNEIK-ALKSRKKQMEKDNSELELKMEKVfqgtdEQLNDlyHNHQRTVREKERELVDCQRE 327
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   102 YELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLE-----LSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIE 176
Cdd:TIGR00606  328 LEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRArdsliQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEA 407
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   177 ELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDS-HLAELQEKIQQTEATN 255
Cdd:TIGR00606  408 KTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSdRILELDQELRKAEREL 487
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   256 KILQEKLNE--MSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLG--QLHSSEG 331
Cdd:TIGR00606  488 SKAEKNSLTetLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHsdELTSLLG 567
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   332 TSPAQQQValldlqsalfcsQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAH------ESEQQKEASWKHN-------Q 398
Cdd:TIGR00606  568 YFPNKKQL------------EDWLHSKSKEINQTRDRLAKLNKELASLEQNKNhinnelESKEEQLSSYEDKlfdvcgsQ 635
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   399 ELRKALQQLQEELQNKSQQLRAWEAEK------YNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT-LEANE 471
Cdd:TIGR00606  636 DEESDLERLKEEIEKSSKQRAMLAGATavysqfITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDkLKSTE 715
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   472 MLLEKLRQRIHDKAVALERaideKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQS-MESLLRAKGLEVEq 550
Cdd:TIGR00606  716 SELKKKEKRRDEMLGLAPG----RQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTiMPEEESAKVCLTD- 790
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   551 lSTTCQNLQWLKEEMETKFSRWQKEQESIiqQLQTSLHDRNKEVEDlsatllcklgpgqseiAEELCQRLQRKERMLQDL 630
Cdd:TIGR00606  791 -VTIMERFQMELKDVERKIAQQAAKLQGS--DLDRTVQQVNQEKQE----------------KQHELDTVVSKIELNRKL 851
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   631 LSDRNKQVLEHEMEIQGLLQ---SVSTREQESQAAAEKLVqalmERNSELQALRQylggrdslmsqaPISNQQAEVTPTG 707
Cdd:TIGR00606  852 IQDQQEQIQHLKSKTNELKSeklQIGTNLQRRQQFEEQLV----ELSTEVQSLIR------------EIKDAKEQDSPLE 915
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   708 RLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRStlgDLDTVAGLEKELSNAKEELELMAKKERESqmELSALQSMMAVQE 787
Cdd:TIGR00606  916 TFLEKDQQEKEELISSKETSNKKAQDKVNDIKE---KVKNIHGYMKDIENKIQDGKDDYLKQKET--ELNTVNAQLEECE 990
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*
gi 525313637   788 EELQVQAADMESLTRNI---QIKEDLIKDLQMQLVDPEDIPAMER 829
Cdd:TIGR00606  991 KHQEKINEDMRLMRQDIdtqKIQERWLQDNLTLRKRENELKEVEE 1035
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
241-455 6.95e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.00  E-value: 6.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  241 LAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLhQ 320
Cdd:COG4942    29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEEL-A 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  321 SQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLeIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQEL 400
Cdd:COG4942   108 ELLRALYRLGRQPPLALLLSPEDFLDAVRRLQY-LKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEE 186
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 525313637  401 RKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRE 455
Cdd:COG4942   187 RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
223-693 1.04e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 54.28  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  223 KLNSHETTITQqsvSDSHLAELQEKIQQTEATNKILQEKLNEmsYELKcaQESSQKQDGTIQNLKETLKSRERETEELYQ 302
Cdd:PRK02224  207 RLNGLESELAE---LDEEIERYEEQREQARETRDEADEVLEE--HEER--REELETLEAEIEDLRETIAETEREREELAE 279
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  303 VIEGQNDTMAKLREMLHqsqlGQLHSSEGTSPAQQqvALLDLQSALfcsQLEIQKLQRVVRQKERQLADAKQCVQFVEAA 382
Cdd:PRK02224  280 EVRDLRERLEELEEERD----DLLAEAGLDDADAE--AVEARREEL---EDRDEELRDRLEECRVAAQAHNEEAESLRED 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  383 AHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAE------KYNEIRTQEQNIQHLNHSL-SHKEQLLQEFRE 455
Cdd:PRK02224  351 ADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEieelreRFGDAPVDLGNAEDFLEELrEERDELREREAE 430
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  456 LLQYRDNSDKTLEANEMLLEKLR-----QRIHDKAVAleRAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDV---- 526
Cdd:PRK02224  431 LEATLRTARERVEEAEALLEAGKcpecgQPVEGSPHV--ETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLveae 508
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  527 --LSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQK---EQESIIQQLQTSLHDRNKEVEDLSATL 601
Cdd:PRK02224  509 drIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREaaaEAEEEAEEAREEVAELNSKLAELKERI 588
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  602 --LCKLGPGQSEIAE--ELCQRLQRKERMLQDL-------LSDRNKQVLEHEMEIQGllqsvsTREQESQAAAEKLVQAL 670
Cdd:PRK02224  589 esLERIRTLLAAIADaeDEIERLREKREALAELnderrerLAEKRERKRELEAEFDE------ARIEEAREDKERAEEYL 662
                         490       500
                  ....*....|....*....|...
gi 525313637  671 MERNSELQALRQylgGRDSLMSQ 693
Cdd:PRK02224  663 EQVEEKLDELRE---ERDDLQAE 682
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
2-684 1.50e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.92  E-value: 1.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637     2 SNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQ-------------KYEASREDIYKRNIELKVEVESLKRELQDKKQH 68
Cdd:TIGR02169  286 EEEQLRVKEKIGELEAEIASLERSIAEKERELEDaeerlakleaeidKLLAEIEELEREIEEERKRRDKLTEEYAELKEE 365
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    69 LDKTWADVENLnsqnEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEkecnlelseklkgvt 148
Cdd:TIGR02169  366 LEDLRAELEEV----DKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLN--------------- 426
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   149 knwEDVPGDQVKPDQYTEALAQRDKRIEELNQSLaaqERLVEQLSREKQQLLHLLEEptsmevqpmteellkQQKLNshe 228
Cdd:TIGR02169  427 ---AAIAGIEAKINELEEEKEDKALEIKKQEWKL---EQLAADLSKYEQELYDLKEE---------------YDRVE--- 482
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   229 ttitqqsvsdSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETE-----ELYQV 303
Cdd:TIGR02169  483 ----------KELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEvaagnRLNNV 552
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   304 IEGQNDTMAKLREMLHQSQLGQL----------HSSEGTSPAQQQVA--LLDL---------------QSALFCSQLEIQ 356
Cdd:TIGR02169  553 VVEDDAVAKEAIELLKRRKAGRAtflplnkmrdERRDLSILSEDGVIgfAVDLvefdpkyepafkyvfGDTLVVEDIEAA 632
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   357 KLQ----RVVRQKERQL---------ADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEA 423
Cdd:TIGR02169  633 RRLmgkyRMVTLEGELFeksgamtggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELS 712
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   424 EKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYrdnSDKTLEANEMLLEKLRQRIHDKavalERAIDEKFSALEEKE 503
Cdd:TIGR02169  713 DASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSS---LEQEIENVKSELKELEARIEEL----EEDLHKLEEALNDLE 785
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   504 KELRQLRlaVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIiqql 583
Cdd:TIGR02169  786 ARLSHSR--IPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENL---- 859
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   584 qtslhdrNKEVEDLsatllcklgpgQSEIAEelcqrLQRKERMLQDLLSDRNKQVLEHEMEiqglLQSVSTREQESQAAA 663
Cdd:TIGR02169  860 -------NGKKEEL-----------EEELEE-----LEAALRDLESRLGDLKKERDELEAQ----LRELERKIEELEAQI 912
                          730       740
                   ....*....|....*....|.
gi 525313637   664 EKLVQALMERNSELQALRQYL 684
Cdd:TIGR02169  913 EKKRKRLSELKAKLEALEEEL 933
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
257-694 1.82e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.23  E-value: 1.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  257 ILQEKLNEMSYEL-KCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMlhQSQLGQLhssegtspa 335
Cdd:COG4717    46 MLLERLEKEADELfKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEEL--EAELEEL--------- 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  336 QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKeaswkhnQELRKALQQLQEELQNKS 415
Cdd:COG4717   115 REELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELE-------AELAELQEELEELLEQLS 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  416 QQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEK 495
Cdd:COG4717   188 LATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGS 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  496 FSALEEKEKELRQLRLAVRErdHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLqWLKEEMETKFSRWQKE 575
Cdd:COG4717   268 LLSLILTIAGVLFLVLGLLA--LLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAAL-GLPPDLSPEELLELLD 344
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  576 QESIIQQLQTSLHDRNKEV-----EDLSATLLCKLGPGQSEIAEELCQRLQRKERmLQDLLSDRNKQVLEHEMEIQGLLQ 650
Cdd:COG4717   345 RIEELQELLREAEELEEELqleelEQEIAALLAEAGVEDEEELRAALEQAEEYQE-LKEELEELEEQLEELLGELEELLE 423
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 525313637  651 SVSTREQESQaaAEKLVQALMERNSELQALRQYLGGRDSLMSQA 694
Cdd:COG4717   424 ALDEEELEEE--LEELEEELEELEEELEELREELAELEAELEQL 465
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
34-484 2.72e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.85  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   34 QQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNS-----QNEAELRRQFEERQQETEHVYELLENK 108
Cdd:COG4717    79 ELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQllplyQELEALEAELAELPERLEELEERLEEL 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  109 IQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQvkpDQYTEALAQRDKRIEELNQSLAA--QE 186
Cdd:COG4717   159 RELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRL---AELEEELEEAQEELEELEEELEQleNE 235
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  187 RLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVsdSHLAELQEKIQQTEATNKILQEKLNEMS 266
Cdd:COG4717   236 LEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGL--LALLFLLLAREKASLGKEAEELQALPAL 313
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  267 YELKcaqesSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQS 346
Cdd:COG4717   314 EELE-----EEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELR 388
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  347 ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEAswkhnQELRKALQQLQEELQNKSQQLRAWEAeky 426
Cdd:COG4717   389 AALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEEL-----EELEEELEELEEELEELREELAELEA--- 460
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 525313637  427 nEIRTQEQniqhlNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDK 484
Cdd:COG4717   461 -ELEQLEE-----DGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREE 512
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1841-2018 2.92e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 2.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1841 ADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSH 1920
Cdd:COG1196   241 LEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEE 320
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1921 VSREHSQET---ESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQ 1997
Cdd:COG1196   321 LEEELAELEeelEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAA 400
                         170       180
                  ....*....|....*....|.
gi 525313637 1998 QCEEKQQLFESLQSELQIYEA 2018
Cdd:COG1196   401 QLEELEEAEEALLERLERLEE 421
mukB PRK04863
chromosome partition protein MukB;
169-547 3.05e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 53.04  E-value: 3.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  169 AQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEE---------PTSMEVQPMTEELLKQQKLNSHETtitqqsvsds 239
Cdd:PRK04863  782 AAREKRIEQLRAEREELAERYATLSFDVQKLQRLHQAfsrfigshlAVAFEADPEAELRQLNRRRVELER---------- 851
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  240 HLAELQEKIQQTEATNKILQEKLNEMSyelKCAQESSQKQDgtiqnlkETLKSRERETEElyQVIEGQNdtmAKLREMLH 319
Cdd:PRK04863  852 ALADHESQEQQQRSQLEQAKEGLSALN---RLLPRLNLLAD-------ETLADRVEEIRE--QLDEAEE---AKRFVQQH 916
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  320 QSQLGQLhssegtspaQQQVALLDlqsalfCSQLEIQKLQRVVRQKERQLADAKQCV----QFVEAAAH----ESEQQKE 391
Cdd:PRK04863  917 GNALAQL---------EPIVSVLQ------SDPEQFEQLKQDYQQAQQTQRDAKQQAfaltEVVQRRAHfsyeDAAEMLA 981
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  392 ASWKHNQELRKALQQLQEELQNKSQQLRAWEAE--KYNEIRTQeqniqhLNHSLSHKEQLLQEFRELLQyrdnsDKTLEA 469
Cdd:PRK04863  982 KNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQlaQYNQVLAS------LKSSYDAKRQMLQELKQELQ-----DLGVPA 1050
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  470 NEMLLEKLRQRiHDKAVALERAIDEKFSALEEK----EKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG 545
Cdd:PRK04863 1051 DSGAEERARAR-RDELHARLSANRSRRNQLEKQltfcEAEMDNLTKKLRKLERDYHEMREQVVNAKAGWCAVLRLVKDNG 1129

                  ..
gi 525313637  546 LE 547
Cdd:PRK04863 1130 VE 1131
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
358-849 3.30e-06

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 52.44  E-value: 3.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   358 LQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRaweaEKYNEIRTQEQNIQ 437
Cdd:pfam05557   11 LSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALR----EQAELNRLKKKYLE 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   438 HLNHSLSHKEQLL-----------QEFRELLQYRDNSDKTLEANEMLLEKLRQRiHDKAVALERAIDEKFSALEEKEKEL 506
Cdd:pfam05557   87 ALNKKLNEKESQLadarevisclkNELSELRRQIQRAELELQSTNSELEELQER-LDLLKAKASEAEQLRQNLEKQQSSL 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   507 RQLRLAVRERDHDLERLRD----VLSSNE--ATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEE---METKFSRWQKEQE 577
Cdd:pfam05557  166 AEAEQRIKELEFEIQSQEQdseiVKNSKSelARIPELEKELERLREHNKHLNENIENKLLLKEEvedLKRKLEREEKYRE 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   578 SII------QQLQTSLHDRNKEVEDLSATLlcklgPGQSEIAEELCQrLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQS 651
Cdd:pfam05557  246 EAAtlelekEKLEQELQSWVKLAQDTGLNL-----RSPEDLSRRIEQ-LQQREIVLKEENSSLTSSARQLEKARRELEQE 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   652 VS----------TREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQ---------------------- 699
Cdd:pfam05557  320 LAqylkkiedlnKKLKRHKALVRRLQRRVLLLTKERDGYRAILESYDKELTMSNYSPQllerieeaedmtqkmqahneem 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   700 -----QAEVTPTG-RLGKQTDQGSMQIPSRDDST--SLTAKEDVSIPRStlgDLDTVAGLEKELSNAKEELEL-MAKKER 770
Cdd:pfam05557  400 eaqlsVAEEELGGyKQQAQTLERELQALRQQESLadPSYSKEEVDSLRR---KLETLELERQRLREQKNELEMeLERRCL 476
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   771 ESQMELS---ALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIP--AMERLTQEVLLLREKVASVE 845
Cdd:pfam05557  477 QGDYDPKktkVLHLSMNPAAEAYQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLPetTSTMNFKEVLDLRKELESAE 556

                   ....
gi 525313637   846 SQGQ 849
Cdd:pfam05557  557 LKNQ 560
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
63-622 3.68e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 52.48  E-value: 3.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLaKNEAARMAALVEAEKECNLELSE 142
Cdd:pfam01576   18 KERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQEL-EEILHELESRLEEEEERSQQLQN 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   143 KLKGVTKNWEDVPgDQVKPDQYTEALAQRDK-----RIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMevqpMTEE 217
Cdd:pfam01576   97 EKKKMQQHIQDLE-EQLDEEEAARQKLQLEKvtteaKIKKLEEDILLLEDQNSKLSKERKLLEERISEFTSN----LAEE 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   218 LLKQQKL----NSHETTITqqsvsdshlaELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSR 293
Cdd:pfam01576  172 EEKAKSLsklkNKHEAMIS----------DLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKK 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   294 ERETEELYQVIEGQ----NDTMAKLREML-HQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKL-------QRV 361
Cdd:pfam01576  242 EEELQAALARLEEEtaqkNNALKKIRELEaQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTldttaaqQEL 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   362 VRQKERQLADAKQCVQfVEAAAHESeQQKEASWKHNQELRKALQQLQEELQNKS------QQLRAWEAEKYNEIRTQEQN 435
Cdd:pfam01576  322 RSKREQEVTELKKALE-EETRSHEA-QLQEMRQKHTQALEELTEQLEQAKRNKAnlekakQALESENAELQAELRTLQQA 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   436 IQHLNHSLSHKEQLLQEfrelLQYRDNSDktleanemllEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRE 515
Cdd:pfam01576  400 KQDSEHKRKKLEGQLQE----LQARLSES----------ERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSS 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   516 RDHDLERLRDVLSsnEATMQSMESLLRAKGLEVEQLSTTCQnlqwLKEEMETKfsrwqKEQESIIQQLQTSLHDRNKEVE 595
Cdd:pfam01576  466 LESQLQDTQELLQ--EETRQKLNLSTRLRQLEDERNSLQEQ----LEEEEEAK-----RNVERQLSTLQAQLSDMKKKLE 534
                          570       580
                   ....*....|....*....|....*..
gi 525313637   596 DLSATLlcklgpgqsEIAEELCQRLQR 622
Cdd:pfam01576  535 EDAGTL---------EALEEGKKRLQR 552
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
29-666 6.40e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 51.88  E-value: 6.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   29 LEERMQQKYEA--SREDIYKRNIELKVEVESLKRELQDKKQHLD-------------------KTWADVENLNSQNEAEL 87
Cdd:COG3096   363 LEEQEEVVEEAaeQLAEAEARLEAAEEEVDSLKSQLADYQQALDvqqtraiqyqqavqalekaRALCGLPDLTPENAEDY 442
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   88 RRQFEERQQE-TEHVYELlenkiqllqeESRLAKNEAARmaalveAEKECNLELSEKLKG-VTKNWEDVPGDQV---KPD 162
Cdd:COG3096   443 LAAFRAKEQQaTEEVLEL----------EQKLSVADAAR------RQFEKAYELVCKIAGeVERSQAWQTARELlrrYRS 506
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  163 QytEALAQRDKRIE----ELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSD 238
Cdd:COG3096   507 Q--QALAQRLQQLRaqlaELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELR 584
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  239 SHLAELQEKIQQTEATNKI---LQEKLNEMSYELKCAQESSQKQDGTIQNLKEtlksRERETEELYQVIEGQNDTMAKLR 315
Cdd:COG3096   585 QQLEQLRARIKELAARAPAwlaAQDALERLREQSGEALADSQEVTAAMQQLLE----REREATVERDELAARKQALESQI 660
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  316 EMLHQ------SQLGQLHSSEG---TSPAQQQVALLDLQ--SALFC---SQLEIQKLQRVVRQKErQLADAKQCVQFVE- 380
Cdd:COG3096   661 ERLSQpggaedPRLLALAERLGgvlLSEIYDDVTLEDAPyfSALYGparHAIVVPDLSAVKEQLA-GLEDCPEDLYLIEg 739
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  381 ------AAAHESEQQKEASWKHNQEL--------------RKALQQLQEELQNKSQQLraweAEKYNEIRTQEQNIQHLN 440
Cdd:COG3096   740 dpdsfdDSVFDAEELEDAVVVKLSDRqwrysrfpevplfgRAAREKRLEELRAERDEL----AEQYAKASFDVQKLQRLH 815
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  441 HSLShkeQLLQEFRELlqyrdnsdkTLEAN-EMLLEKLRQRIhdkavaleRAIDEKFSALEEKEKELRQLRLAVRER--- 516
Cdd:COG3096   816 QAFS---QFVGGHLAV---------AFAPDpEAELAALRQRR--------SELERELAQHRAQEQQLRQQLDQLKEQlql 875
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  517 ------------DHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQ---WLKEEMETKFSRWQKEQESIIQ 581
Cdd:COG3096   876 lnkllpqanllaDETLADRLEELREELDAAQEAQAFIQQHGKALAQLEPLVAVLQsdpEQFEQLQADYLQAKEQQRRLKQ 955
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  582 QL-------QTSLH-------DRNKEVEDLSATLLCKLgpgqsEIAEELCQRLQRKERMLQDLLSDRNkQVLehemeiQG 647
Cdd:COG3096   956 QIfalsevvQRRPHfsyedavGLLGENSDLNEKLRARL-----EQAEEARREAREQLRQAQAQYSQYN-QVL------AS 1023
                         730
                  ....*....|....*....
gi 525313637  648 LLQSVSTREQESQAAAEKL 666
Cdd:COG3096  1024 LKSSRDAKQQTLQELEQEL 1042
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
331-538 1.25e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.15  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  331 GTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEE 410
Cdd:COG4942    12 ALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKE 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  411 LQNKSQQLRAWEAEKYNEIRTQEQNIQH-------LNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQrihd 483
Cdd:COG4942    92 IAELRAELEAQKEELAELLRALYRLGRQpplalllSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA---- 167
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 525313637  484 kavALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSME 538
Cdd:COG4942   168 ---ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQ 219
PTZ00121 PTZ00121
MAEBL; Provisional
35-698 1.51e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.52  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   35 QKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEE---RQQETEHVYELLENKIQL 111
Cdd:PTZ00121 1176 KKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEakkDAEEAKKAEEERNNEEIR 1255
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  112 LQEESRLAknEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQ 191
Cdd:PTZ00121 1256 KFEEARMA--HFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADA 1333
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  192 LSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKlNEMSYELKC 271
Cdd:PTZ00121 1334 AKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEED-KKKADELKK 1412
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  272 AQESSQKQDGTIQNLKETLKSRE---------------------RETEELYQVIE---------GQNDTMAKLREMLHQS 321
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKADEakkkaeeakkadeakkkaeeaKKAEEAKKKAEeakkadeakKKAEEAKKADEAKKKA 1492
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  322 QLGQLHSSEGTSPAQQQVALLDLQSALfcsqlEIQKLQRVVRQKERQLADAKQCVQFVEAAaheSEQQKEASWKHNQELR 401
Cdd:PTZ00121 1493 EEAKKKADEAKKAAEAKKKADEAKKAE-----EAKKADEAKKAEEAKKADEAKKAEEKKKA---DELKKAEELKKAEEKK 1564
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  402 KALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEfrELLQYRDNSDKTLEANEMLLEKLRQRI 481
Cdd:PTZ00121 1565 KAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA--EEAKIKAEELKKAEEEKKKVEQLKKKE 1642
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  482 HD---KAVALERAIDE-KFSALEEKEKELRQLRLA--VRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEV------- 548
Cdd:PTZ00121 1643 AEekkKAEELKKAEEEnKIKAAEEAKKAEEDKKKAeeAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKkkaeelk 1722
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  549 ---EQLSTTCQNLQWLKEEMETKFSRWQKEQE--SIIQQLQTSLHDRNKEVEDLSATLLcklgpgQSEIAEELCQRLQRK 623
Cdd:PTZ00121 1723 kaeEENKIKAEEAKKEAEEDKKKAEEAKKDEEekKKIAHLKKEEEKKAEEIRKEKEAVI------EEELDEEDEKRRMEV 1796
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 525313637  624 ERMLQDLLSdrNKQVLEhEMEIQGLLQSVSTREQESQAAAEKLVQALMERNsELQALRQYLGGRDSLMSQAPISN 698
Cdd:PTZ00121 1797 DKKIKDIFD--NFANII-EGGKEGNLVINDSKEMEDSAIKEVADSKNMQLE-EADAFEKHKFNKNNENGEDGNKE 1867
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
165-527 1.54e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.68  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  165 TEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLlhlleeptsmevqpmTEELLKQQKLNSHETTITQQSVSDSHLAEL 244
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERLEALEAELDAL---------------QERREALQRLAEYSWDEIDVASAEREIAEL 673
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  245 QEKIQQTEATNKILQEkLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLG 324
Cdd:COG4913   674 EAELERLDASSDDLAA-LEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLE 752
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  325 QLHSSEGTSPAQQQVAlLDLQSalfcsqlEIQKLQRVVRQKERQLADAKQcvQFVEAAAHESeQQKEASWKHNQELRKAL 404
Cdd:COG4913   753 ERFAAALGDAVERELR-ENLEE-------RIDALRARLNRAEEELERAMR--AFNREWPAET-ADLDADLESLPEYLALL 821
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  405 QQLQEE------------LQNKSQQLRAWEAEK-YNEIRTQEQNIQHLNHSLSHkeqllqefrelLQYRDNSDKTLEANE 471
Cdd:COG4913   822 DRLEEDglpeyeerfkelLNENSIEFVADLLSKlRRAIREIKERIDPLNDSLKR-----------IPFGPGRYLRLEARP 890
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 525313637  472 MLLE---KLRQRIHDkavALERAIDEKFSALEEKEKELRQL--RLAVRERDHDLERLRDVL 527
Cdd:COG4913   891 RPDPevrEFRQELRA---VTSGASLFDEELSEARFAALKRLieRLRSEEEESDRRWRARVL 948
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
351-527 2.29e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.91  E-value: 2.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  351 SQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEEL-QNKSQQLRAWEAekynEI 429
Cdd:COG4913   272 AELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIrGNGGDRLEQLER----EI 347
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  430 RTQEQNIQHLNHSLSHKEQLLQEF--------RELLQYRDNSDKTLEAnemlLEKLRQRIHDKAVALERAIDEKFSALEE 501
Cdd:COG4913   348 ERLERELEERERRRARLEALLAALglplpasaEEFAALRAEAAALLEA----LEEELEALEEALAEAEAALRDLRRELRE 423
                         170       180
                  ....*....|....*....|....*.
gi 525313637  502 KEKELRQLRLAVRERDHDLERLRDVL 527
Cdd:COG4913   424 LEAEIASLERRKSNIPARLLALRDAL 449
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
163-682 3.02e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 49.58  E-value: 3.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   163 QYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
Cdd:TIGR00618  153 EFAQFLKAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLR 232
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   243 ELQEKIQQTEATNKILQEKLNEmsyelkcaQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDtmaKLREMLHQSQ 322
Cdd:TIGR00618  233 EALQQTQQSHAYLTQKREAQEE--------QLKKQQLLKQLRARIEELRAQEAVLEETQERINRARK---AAPLAAHIKA 301
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   323 LGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFveAAAHESEQQKEASWKHNQELRK 402
Cdd:TIGR00618  302 VTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHI--RDAHEVATSIREISCQQHTLTQ 379
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   403 ALQQLQEELQNKSQQLRAWEAEKYN--------EIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ--YRDNSDKTLEANEM 472
Cdd:TIGR00618  380 HIHTLQQQKTTLTQKLQSLCKELDIlqreqatiDTRTSAFRDLQGQLAHAKKQQELQQRYAELCaaAITCTAQCEKLEKI 459
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   473 LLEKLRQRIHDKAVALERAidekfSALEEKEKELRQLRLAVRERDHDLER-LRDVLSSNEATMQSM------ESLLRAKG 545
Cdd:TIGR00618  460 HLQESAQSLKEREQQLQTK-----EQIHLQETRKKAVVLARLLELQEEPCpLCGSCIHPNPARQDIdnpgplTRRMQRGE 534
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   546 LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATL-----LCKLGPGQSEIAEELCQRL 620
Cdd:TIGR00618  535 QTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQnitvrLQDLTEKLSEAEDMLACEQ 614
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 525313637   621 QRKERMLQDLLSDRNK-QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQ 682
Cdd:TIGR00618  615 HALLRKLQPEQDLQDVrLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELLAS 677
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
50-262 3.38e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 3.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   50 ELKVEVESLKRELQDKKQHLDKTWADVENLNSQneaelRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAAL 129
Cdd:COG4942    24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQ-----LAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  130 VEAEKEcnlELSEKLKGVTKNWE----------DVPGDQVKPDQYTEALAQ-RDKRIEELNQSLAAQERLVEQLSREKQQ 198
Cdd:COG4942    99 LEAQKE---ELAELLRALYRLGRqpplalllspEDFLDAVRRLQYLKYLAPaRREQAEELRADLAELAALRAELEAERAE 175
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 525313637  199 LLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSdshLAELQEKIQQTEATNKILQEKL 262
Cdd:COG4942   176 LEALLAELEEERAALEALKAERQKLLARLEKELAELAAE---LAELQQEAEELEALIARLEAEA 236
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
335-547 3.47e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 3.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  335 AQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNK 414
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  415 SQQLRAWEAEKY--------------NEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQR 480
Cdd:COG4942   103 KEELAELLRALYrlgrqpplalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAE 182
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 525313637  481 IHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLE 547
Cdd:COG4942   183 LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFA 249
PTZ00121 PTZ00121
MAEBL; Provisional
54-682 3.47e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 3.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   54 EVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQ--EESRLA----KNEAARMA 127
Cdd:PTZ00121 1105 KTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARkaEEARKAedakKAEAARKA 1184
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  128 ALV-EAEKECNLELSEKLKGVTKNWEDVPGDQVKPdqytealAQRDKRIEELNQSLAAQERLVEQLSREKQQllhLLEEP 206
Cdd:PTZ00121 1185 EEVrKAEELRKAEDARKAEAARKAEEERKAEEARK-------AEDAKKAEAVKKAEEAKKDAEEAKKAEEER---NNEEI 1254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  207 TSMEVQPMTEELLKQQKLNSHETTITQQsVSDSHLAELQEKIQQTEATNKIlqEKLNEMSYELKCAQESSQKQdgtiQNL 286
Cdd:PTZ00121 1255 RKFEEARMAHFARRQAAIKAEEARKADE-LKKAEEKKKADEAKKAEEKKKA--DEAKKKAEEAKKADEAKKKA----EEA 1327
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  287 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKE 366
Cdd:PTZ00121 1328 KKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKA 1407
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  367 RQLADAKQCVQFVEAAAHESEQQKEASW--KHNQELRKAlqqlqEELQNKSQQLR-AWEAEKYNEIRTQEQNIQHLNHSL 443
Cdd:PTZ00121 1408 DELKKAAAAKKKADEAKKKAEEKKKADEakKKAEEAKKA-----DEAKKKAEEAKkAEEAKKKAEEAKKADEAKKKAEEA 1482
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  444 SHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAiDEKFSALEEKEKELRQLRLAVR--ERDHDLE 521
Cdd:PTZ00121 1483 KKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKA-EEAKKADEAKKAEEKKKADELKkaEELKKAE 1561
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  522 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTslhdRNKEVEDLSATL 601
Cdd:PTZ00121 1562 EKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEEL----KKAEEEKKKVEQ 1637
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  602 LCKLGPGQSEIAEELCQRLQ----RKERMLQDLLSDRNK-QVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSE 676
Cdd:PTZ00121 1638 LKKKEAEEKKKAEELKKAEEenkiKAAEEAKKAEEDKKKaEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKK 1717

                  ....*.
gi 525313637  677 LQALRQ 682
Cdd:PTZ00121 1718 AEELKK 1723
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
446-700 4.35e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 4.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  446 KEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIhdkaVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRD 525
Cdd:COG4942    29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRI----AALARRIRALEQELAALEAELAELEKEIAELRAELEAQKE 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  526 VLSSNEATMQSMESLLRAK-GLEVEQLSTTCQNLQWLKEemetkFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLlck 604
Cdd:COG4942   105 ELAELLRALYRLGRQPPLAlLLSPEDFLDAVRRLQYLKY-----LAPARREQAEELRADLAELAALRAELEAERAEL--- 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  605 lgpgqseiaEELCQRLQRKERMLQDLLSDRNKqvlehemeiqgLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 684
Cdd:COG4942   177 ---------EALLAELEEERAALEALKAERQK-----------LLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
                         250
                  ....*....|....*.
gi 525313637  685 GGRDSLMSQAPISNQQ 700
Cdd:COG4942   237 AAAAERTPAAGFAALK 252
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
15-494 5.97e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 48.52  E-value: 5.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   15 LKKENFSLKLRIYFLEERMQQKYEASR--EDIYKRNIELK------VEVESLKRELQDKKQHLDKTWADVENLNSQNEAE 86
Cdd:PRK03918  250 LEGSKRKLEEKIRELEERIEELKKEIEelEEKVKELKELKekaeeyIKLSEFYEEYLDELREIEKRLSRLEEEINGIEER 329
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   87 LR---------RQFEERQQETEHVYELLENKIQLLQEesrlAKNEAARMAALVEAEKECNLE-LSEKLKGVTKNWEDVpg 156
Cdd:PRK03918  330 IKeleekeerlEELKKKLKELEKRLEELEERHELYEE----AKAKKEELERLKKRLTGLTPEkLEKELEELEKAKEEI-- 403
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  157 dQVKPDQYTEALAQRDKRIEELNQSLAA-------------------QERLVEQLSREKQQLLHLLEEPTSMEVQPMTEE 217
Cdd:PRK03918  404 -EEEISKITARIGELKKEIKELKKAIEElkkakgkcpvcgrelteehRKELLEEYTAELKRIEKELKEIEEKERKLRKEL 482
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  218 LLKQQKLNSHETTITQQSVSDsHLAELQEKiqqteaTNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERET 297
Cdd:PRK03918  483 RELEKVLKKESELIKLKELAE-QLKELEEK------LKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELK 555
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  298 EELYQVIEGQNDTMAKLREMLHQ------SQLGQLHS--SEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQL 369
Cdd:PRK03918  556 KKLAELEKKLDELEEELAELLKEleelgfESVEELEErlKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEEL 635
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  370 ADAKQCVQfvEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEaekyNEIRTQEQNIQHLNHSLSHKEQL 449
Cdd:PRK03918  636 AETEKRLE--ELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELE----KRREEIKKTLEKLKEELEEREKA 709
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 525313637  450 LQEFRELlqyrdnsDKTLEANEMLLEKLRQRihdKAVALERAIDE 494
Cdd:PRK03918  710 KKELEKL-------EKALERVEELREKVKKY---KALLKERALSK 744
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
81-546 6.31e-05

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 48.21  E-value: 6.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    81 SQNEAE-LRRQFEERQQETEHVYELLENKIQLLQEEsrlAKNEAARMAALVEAEkecnlELSEKLKGVTKNWEDVPGD-- 157
Cdd:pfam07111  195 AQKEAElLRKQLSKTQEELEAQVTLVESLRKYVGEQ---VPPEVHSQTWELERQ-----ELLDTMQHLQEDRADLQATve 266
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   158 --QVKPDQYTEALAQRDkriEELNQSLAAQERLVEQLSREKQQLLHLLEEPT-SMEVQpmteelLKQQKLnSHETTITQQ 234
Cdd:pfam07111  267 llQVRVQSLTHMLALQE---EELTRKIQPSDSLEPEFPKKCRSLLNRWREKVfALMVQ------LKAQDL-EHRDSVKQL 336
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   235 SVsdsHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERET----EELYQVIEGQNDT 310
Cdd:pfam07111  337 RG---QVAELQEQVTSQSQEQAILQRALQDKAAEVEVERMSAKGLQMELSRAQEARRRQQQQTasaeEQLKFVVNAMSST 413
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   311 MAKLREMLHQSQ----------------LGQLHSSEGTSPAQQQVALLDLQS-----------ALFCSQLEIQKLQRVVR 363
Cdd:pfam07111  414 QIWLETTMTRVEqavaripslsnrlsyaVRKVHTIKGLMARKVALAQLRQEScpppppappvdADLSLELEQLREERNRL 493
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   364 QKERQLAdAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAW---------EAEKYNEIRTQEQ 434
Cdd:pfam07111  494 DAELQLS-AHLIQQEVGRAREQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVArqgqqesteEAASLRQELTQQQ 572
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   435 NI--QHLNHSLSHKEQLLQEfrellQYRDNSDKTLEAnemlleklrQRIHDKAVALERAIDEKFSALEEKEKELRqlRLA 512
Cdd:pfam07111  573 EIygQALQEKVAEVETRLRE-----QLSDTKRRLNEA---------RREQAKAVVSLRQIQHRATQEKERNQELR--RLQ 636
                          490       500       510
                   ....*....|....*....|....*....|....
gi 525313637   513 VRERDHDLERLRDVLSSNEATMQSMESLLRAKGL 546
Cdd:pfam07111  637 DEARKEEGQRLARRVQELERDKNLMLATLQQEGL 670
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
237-425 6.75e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.90  E-value: 6.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  237 SDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAK-LR 315
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGErAR 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  316 EMLHQ----SQLGQLHSSEGTSPAQQQVALLD-LQSAlfcSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQK 390
Cdd:COG3883    94 ALYRSggsvSYLDVLLGSESFSDFLDRLSALSkIADA---DADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAK 170
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 525313637  391 EASWKHNQELRKALQQLQEELQNKSQQLRAWEAEK 425
Cdd:COG3883   171 AELEAQQAEQEALLAQLSAEEAAAEAQLAELEAEL 205
PTZ00121 PTZ00121
MAEBL; Provisional
31-682 7.04e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 7.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQ 110
Cdd:PTZ00121 1112 EEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAE 1191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  111 LLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVE 190
Cdd:PTZ00121 1192 ELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAA 1271
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  191 QLSREKQQllhlLEEPTSMEVQPMTEELLKQQKLNSHEtTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELK 270
Cdd:PTZ00121 1272 IKAEEARK----ADELKKAEEKKKADEAKKAEEKKKAD-EAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAE 1346
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  271 CAQESSQKQDGTIQNLKETLKSRERETEELYQviegQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQqvalLDLQSALFC 350
Cdd:PTZ00121 1347 AAKAEAEAAADEAEAAEEKAEAAEKKKEEAKK----KADAAKKKAEEKKKADEAKKKAEEDKKKADE----LKKAAAAKK 1418
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  351 SQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQK-EASWKHNQELRKAlqqlqEELQNKSQqlrawEAEKYNEI 429
Cdd:PTZ00121 1419 KADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKaEEAKKKAEEAKKA-----DEAKKKAE-----EAKKADEA 1488
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  430 RTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD--NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKeLR 507
Cdd:PTZ00121 1489 KKKAEEAKKKADEAKKAAEAKKKADEAKKAEEakKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKK-AE 1567
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  508 QLRLAVRERDHDLERLRDVLSSNEATMQS-MESLLRAKGLEVEQLSTtcqnlqwlKEEMETKFSRWQKEQE--SIIQQLQ 584
Cdd:PTZ00121 1568 EAKKAEEDKNMALRKAEEAKKAEEARIEEvMKLYEEEKKMKAEEAKK--------AEEAKIKAEELKKAEEekKKVEQLK 1639
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  585 TSLHDRNKEVEDLSatllcKLGPGQSEIAEELCQRLQRKERMLQDLLSD-----RNKQVLEHEMEIQGLLQSVSTREQES 659
Cdd:PTZ00121 1640 KKEAEEKKKAEELK-----KAEEENKIKAAEEAKKAEEDKKKAEEAKKAeedekKAAEALKKEAEEAKKAEELKKKEAEE 1714
                         650       660
                  ....*....|....*....|...
gi 525313637  660 QAAAEKLVQALMERNSELQALRQ 682
Cdd:PTZ00121 1715 KKKAEELKKAEEENKIKAEEAKK 1737
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
474-932 8.22e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 48.11  E-value: 8.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  474 LEKLRQRIHDKAVALERAIDEKFSALEEKEKE------------LRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLL 541
Cdd:PRK02224  164 LEEYRERASDARLGVERVLSDQRGSLDQLKAQieekeekdlherLNGLESELAELDEEIERYEEQREQARETRDEADEVL 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  542 ---RAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEqesiIQQLQTSLHDRNKEVEDLSATllCKLGPGQSEIAEELCQ 618
Cdd:PRK02224  244 eehEERREELETLEAEIEDLRETIAETEREREELAEE----VRDLRERLEELEEERDDLLAE--AGLDDADAEAVEARRE 317
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  619 RLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISN 698
Cdd:PRK02224  318 ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELR 397
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  699 QQAEVTPTgRLGKQTDQGSMQIPSRDDS----TSLTAK---------------------------EDVSIPRSTLGDLDT 747
Cdd:PRK02224  398 ERFGDAPV-DLGNAEDFLEELREERDELrereAELEATlrtarerveeaealleagkcpecgqpvEGSPHVETIEEDRER 476
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  748 VAGLEKELSNAKEELELMAKK-ER-----ESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDP 821
Cdd:PRK02224  477 VEELEAELEDLEEEVEEVEERlERaedlvEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEK 556
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  822 EDipAMERLTQEVLLLREKVASVESQGQEISgNRRQQL------LLMLEGLVDERSRLNEALQA------ERQLYSSlvk 889
Cdd:PRK02224  557 RE--AAAEAEEEAEEAREEVAELNSKLAELK-ERIESLerirtlLAAIADAEDEIERLREKREAlaelndERRERLA--- 630
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 525313637  890 fhahpESSERDRTLQVE-----LEGAQVLRSRLEEVLGRSLERLNRLE 932
Cdd:PRK02224  631 -----EKRERKRELEAEfdearIEEAREDKERAEEYLEQVEEKLDELR 673
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
13-621 1.10e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 47.86  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    13 NDLKKENFSLKLRIYFLEERMQQKYEASrediyKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAE---LRR 89
Cdd:pfam01576  148 SKLSKERKLLEERISEFTSNLAEEEEKA-----KSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGEstdLQE 222
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    90 QFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLkgvtknwEDVPGDQVkpdQYTEALA 169
Cdd:pfam01576  223 QIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQ-------EDLESERA---ARNKAEK 292
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   170 QRDKRIEELN----------QSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEelLKQQKLNSHETTITQQSVSDS 239
Cdd:pfam01576  293 QRRDLGEELEalkteledtlDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQE--MRQKHTQALEELTEQLEQAKR 370
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   240 HLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLH 319
Cdd:pfam01576  371 NKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLN 450
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   320 QSQLGQLHSSEGTSPAQQQvaLLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQE 399
Cdd:pfam01576  451 EAEGKNIKLSKDVSSLESQ--LQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSD 528
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   400 LRKALQQ--------------LQEELQNKSQQL--RAWEAEKYNEIRTQEQ--------NIQHLNHSLSHKEQLLQEFRE 455
Cdd:pfam01576  529 MKKKLEEdagtlealeegkkrLQRELEALTQQLeeKAAAYDKLEKTKNRLQqelddllvDLDHQRQLVSNLEKKQKKFDQ 608
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   456 LL-QYRDNSDKTLEANEMLLEKLRQRiHDKAVALERAIDEKFSALEEKEKELRQLRLavrerdhdleRLRDVLSSNEATM 534
Cdd:pfam01576  609 MLaEEKAISARYAEERDRAEAEAREK-ETRALSLARALEEALEAKEELERTNKQLRA----------EMEDLVSSKDDVG 677
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   535 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEM---ETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSE 611
Cdd:pfam01576  678 KNVHELERSKRALEQQVEEMKTQLEELEDELqatEDAKLRLEVNMQALKAQFERDLQARDEQGEEKRRQLVKQVRELEAE 757
                          650
                   ....*....|
gi 525313637   612 IAEELCQRLQ 621
Cdd:pfam01576  758 LEDERKQRAQ 767
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
232-976 1.13e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 47.73  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   232 TQQSVSDSHLAELQEKIQQTEATNKIlQEKLNEMSYELKCAQESSQKQDGTIQNLKEtlksRERETEELYQVIEGQNDTM 311
Cdd:TIGR00606  197 TQGQKVQEHQMELKYLKQYKEKACEI-RDQITSKEAQLESSREIVKSYENELDPLKN----RLKEIEHNLSKIMKLDNEI 271
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   312 AKL--REMLHQSQLGQLHssegtspaqqqvalLDLQSALFCSQLEIQKL----QRVVRQKERQLADAKQCVQFVEAAAHE 385
Cdd:TIGR00606  272 KALksRKKQMEKDNSELE--------------LKMEKVFQGTDEQLNDLyhnhQRTVREKERELVDCQRELEKLNKERRL 337
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   386 SEQQKeaswkhnQELRKALQQLQEELQNKSQQLRAWEAEKY-NEIRTQEQNIQHLNHSlshkEQLLQEFRELLQYRDNSD 464
Cdd:TIGR00606  338 LNQEK-------TELLVEQGRLQLQADRHQEHIRARDSLIQsLATRLELDGFERGPFS----ERQIKNFHTLVIERQEDE 406
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   465 --------KTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERD---HDLERLRDVLSSNEAT 533
Cdd:TIGR00606  407 aktaaqlcADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEgssDRILELDQELRKAERE 486
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   534 MQSME--SLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQL-----QTSLHDRNKEVEDLSATLLCKLG 606
Cdd:TIGR00606  487 LSKAEknSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEmltkdKMDKDEQIRKIKSRHSDELTSLL 566
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   607 P--GQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQAL--MERNSELQALRQ 682
Cdd:TIGR00606  567 GyfPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCgsQDEESDLERLKE 646
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   683 YLggRDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEDVS-IPRSTLGDLDTVAGLEKELSNAKEE 761
Cdd:TIGR00606  647 EI--EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISdLQSKLRLAPDKLKSTESELKKKEKR 724
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   762 LELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPE----DIPAMERLTQEVLLL 837
Cdd:TIGR00606  725 RDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKvcltDVTIMERFQMELKDV 804
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   838 REKVASVESQGQEISGNRR-QQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERD-RTLQVELEGAQVLRS 915
Cdd:TIGR00606  805 ERKIAQQAAKLQGSDLDRTvQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNElKSEKLQIGTNLQRRQ 884
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 525313637   916 RLEEvlgRSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEK 976
Cdd:TIGR00606  885 QFEE---QLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDK 942
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1912-2060 1.20e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.74  E-value: 1.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1912 RRLQAQLSHVSREHS---QETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRL 1988
Cdd:TIGR02168  263 QELEEKLEELRLEVSeleEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 525313637  1989 QHKLVLLQQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAysldachqipLSSDLSHLVAEVRALRGQLEQ 2060
Cdd:TIGR02168  343 EEKLEELKEELESLEAELEELEAELEELESRLEELEEQLET----------LRSKVAQLELQIASLNNEIER 404
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
294-682 1.61e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.04  E-value: 1.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   294 ERETEELYQVIEGQ---NDTMAKLREMLHQSQLgqlhssEGTSPAQQqvALLDLQSALFCSQleiqklQRVVRQKERQLA 370
Cdd:pfam17380  286 ERQQQEKFEKMEQErlrQEKEEKAREVERRRKL------EEAEKARQ--AEMDRQAAIYAEQ------ERMAMERERELE 351
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   371 DAKQcvqfvEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAwEAEKYNEIRTQEQNIQhlnhslshkEQLL 450
Cdd:pfam17380  352 RIRQ-----EERKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQ-ELEAARKVKILEEERQ---------RKIQ 416
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   451 QEFRELLQYRDNSDktlEANEMLLEKLRqrihdkavaleraidekfsalEEKEKELRQLRLAVRERDHDLERLRDVLSSN 530
Cdd:pfam17380  417 QQKVEMEQIRAEQE---EARQREVRRLE---------------------EERAREMERVRLEEQERQQQVERLRQQEEER 472
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   531 EATMQSMESLLRAKGLEVEqlsttcQNLQWLKEEMETKfSRWQKEQESIIQQLQTSLHDRnkevedlsatllcklgpgQS 610
Cdd:pfam17380  473 KRKKLELEKEKRDRKRAEE------QRRKILEKELEER-KQAMIEEERKRKLLEKEMEER------------------QK 527
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 525313637   611 EIAEELCQRLQRKERmlqdllsdRNKQVLEHEMEIQgllqsvstrEQESQAAAEKLVQALMERNSELqaLRQ 682
Cdd:pfam17380  528 AIYEEERRREAEEER--------RKQQEMEERRRIQ---------EQMRKATEERSRLEAMEREREM--MRQ 580
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
489-861 2.45e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.60  E-value: 2.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   489 ERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDvlssneatmqSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETK 568
Cdd:TIGR02169  169 DRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRR----------EREKAERYQALLKEKREYEGYELLKEKEALERQ 238
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   569 FSRWQKEQESI---IQQLQTSLHDRNKEVEDLSATLlcklgpgqSEIAEELcqrlqrkERMLQDLLSDRNKQVLEHEMEI 645
Cdd:TIGR02169  239 KEAIERQLASLeeeLEKLTEEISELEKRLEEIEQLL--------EELNKKI-------KDLGEEEQLRVKEKIGELEAEI 303
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   646 QGLLQSVSTREQESQAAAEKLVQALMERNSEL-------QALRQYLGGRDSLMSQapISNQQAEvtptgRLGKQTDQGSM 718
Cdd:TIGR02169  304 ASLERSIAEKERELEDAEERLAKLEAEIDKLLaeieeleREIEEERKRRDKLTEE--YAELKEE-----LEDLRAELEEV 376
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   719 qipsrdDSTSLTAKEDVSIPRSTLGDL-DTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADM 797
Cdd:TIGR02169  377 ------DKEFAETRDELKDYREKLEKLkREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEI 450
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 525313637   798 ESLTRNI-QIKEDLIKDLQMQLVDPEDIPAME-RLTQEVLLLREKVASVESQGQEISGNRRQQLLL 861
Cdd:TIGR02169  451 KKQEWKLeQLAADLSKYEQELYDLKEEYDRVEkELSKLQRELAEAEAQARASEERVRGGRAVEEVL 516
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
182-702 2.90e-04

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 46.33  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  182 LAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTeelLKQQKLNSHETTITQQSVSDSHLAELQEKIQQteatnkiLQEK 261
Cdd:PRK10246  372 FSQQTSDREQLRQWQQQLTHAEQKLNALPAITLT---LTADEVAAALAQHAEQRPLRQRLVALHGQIVP-------QQKR 441
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  262 LNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEgQNDTMAKLREMLHQSQLGQLHSSEGTS--PAQQQV 339
Cdd:PRK10246  442 LAQLQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADVKTICE-QEARIKDLEAQRAQLQAGQPCPLCGSTshPAVEAY 520
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  340 ALLDLQSalfcSQLEIQKLQRVVRQ-KERQLADAKQcvqfVEAAAHESEQQKEASwkhnQELRKALQQLQEELQNKSQQL 418
Cdd:PRK10246  521 QALEPGV----NQSRLDALEKEVKKlGEEGAALRGQ----LDALTKQLQRDESEA----QSLRQEEQALTQQWQAVCASL 588
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  419 raweaekyNEIRTQEQNIQH-LNHSLSHKEQLLQefrelLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAI----- 492
Cdd:PRK10246  589 --------NITLQPQDDIQPwLDAQEEHERQLRL-----LSQRHELQGQIAAHNQQIIQYQQQIEQRQQQLLTALagyal 655
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  493 -----DEKFSALEEKEKEL-----RQLRL-AVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEV--EQLSTTCQnLQ 559
Cdd:PRK10246  656 tlpqeDEEASWLATRQQEAqswqqRQNELtALQNRIQQLTPLLETLPQSDDLPHSEETVALDNWRQVheQCLSLHSQ-LQ 734
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  560 WLKEEMETKFSRWQKEQESIIQQLQTSLHDrnkeveDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVL 639
Cdd:PRK10246  735 TLQQQDVLEAQRLQKAQAQFDTALQASVFD------DQQAFLAALLDEETLTQLEQLKQNLENQRQQAQTLVTQTAQALA 808
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  640 EHEMEIQGLLQSVSTREQeSQAAAEKLVQALME---RNSEL-QALRQYLGGRD---SLMSQAPISNQQAE 702
Cdd:PRK10246  809 QHQQHRPDGLDLTVTVEQ-IQQELAQLAQQLREnttRQGEIrQQLKQDADNRQqqqALMQQIAQATQQVE 877
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
352-1036 2.92e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.50  E-value: 2.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   352 QLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQ-KEASWKHNQELRKALQQLQeeLQNKSQQLRAWEAEKYNEIR 430
Cdd:TIGR00618  200 TLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQtQQSHAYLTQKREAQEEQLK--KQQLLKQLRARIEELRAQEA 277
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   431 TQEQNIQHLNHSlSHKEQLLQEFRELLQYRDNSDK---TLEANEMLLEKLRQriHDKAVALERAIDEKFSALEEKEkeLR 507
Cdd:TIGR00618  278 VLEETQERINRA-RKAAPLAAHIKAVTQIEQQAQRihtELQSKMRSRAKLLM--KRAAHVKQQSSIEEQRRLLQTL--HS 352
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   508 QLRLAVRERDHDLERlRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLqtsl 587
Cdd:TIGR00618  353 QEIHIRDAHEVATSI-REISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLA---- 427
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   588 HDRNKEVEDLSATLLCKLGPG---QSEIAEE-LCQRLQRKERMLQDLLSDRnKQVLEHEMEIQGLLQSVSTREQESQAAA 663
Cdd:TIGR00618  428 HAKKQQELQQRYAELCAAAITctaQCEKLEKiHLQESAQSLKEREQQLQTK-EQIHLQETRKKAVVLARLLELQEEPCPL 506
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   664 EKlvqALMERNSELQALRQyLGGRDSLMSQ---APISNQQAEVTPTGRLGKQTDQG---SMQIPSRDDSTSLTAKEDVSI 737
Cdd:TIGR00618  507 CG---SCIHPNPARQDIDN-PGPLTRRMQRgeqTYAQLETSEEDVYHQLTSERKQRaslKEQMQEIQQSFSILTQCDNRS 582
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   738 PRStlgdldtVAGLEKELSNAKEELELMAKKERESQMELSAlqsmmavQEEELQVQAADMESLTRNIQIKEDLIKDLQmq 817
Cdd:TIGR00618  583 KED-------IPNLQNITVRLQDLTEKLSEAEDMLACEQHA-------LLRKLQPEQDLQDVRLHLQQCSQELALKLT-- 646
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   818 lvdpedipAMERLTQEVLLLREKVASVES-QGQEISGNRRQQLLLMLEGLVDE----RSRLNEALQAERQLYSSLVKFHA 892
Cdd:TIGR00618  647 --------ALHALQLTLTQERVREHALSIrVLPKELLASRQLALQKMQSEKEQltywKEMLAQCQTLLRELETHIEEYDR 718
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   893 H-PESSERDRTLQVELEGAQVLrsrLEEVLGrSLERLNRlETLAAIGGAAAGDDTEDTSTEFTDSIEEE-AAHHSHQQLV 970
Cdd:TIGR00618  719 EfNEIENASSSLGSDLAAREDA---LNQSLK-ELMHQAR-TVLKARTEAHFNNNEEVTAALQTGAELSHlAAEIQFFNRL 793
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 525313637   971 KVALEKSLATVETQNPSFSPPspmGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEE 1036
Cdd:TIGR00618  794 REEDTHLLKTLEAEIGQEIPS---DEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEE 856
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
31-308 3.18e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.88  E-value: 3.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    31 ERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRR-QFEERQQETEHV-YELLENK 108
Cdd:pfam17380  294 EKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERiRQEERKRELERIrQEEIAME 373
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   109 IQLLQEESRLA-----KNEAARMaalvEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQyTEALAQRDKRIEELNQSLA 183
Cdd:pfam17380  374 ISRMRELERLQmerqqKNERVRQ----ELEAARKVKILEEERQRKIQQQKVEMEQIRAEQ-EEARQREVRRLEEERAREM 448
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   184 AQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQT-------EATNK 256
Cdd:pfam17380  449 ERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKllekemeERQKA 528
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 525313637   257 ILQEKLNEMSYELKCAQESS------QKQDGTIQNLKETLKSRERETEELYQVIEGQN 308
Cdd:pfam17380  529 IYEEERRREAEEERRKQQEMeerrriQEQMRKATEERSRLEAMEREREMMRQIVESEK 586
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
162-430 3.22e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.16  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  162 DQYTEALAQRDKRIEELNQSLAAQERLVEQLsREKQQLLHLleeptSMEVQPMTEELlkqqklnsheTTITQQsvsdshL 241
Cdd:COG3206   171 EEARKALEFLEEQLPELRKELEEAEAALEEF-RQKNGLVDL-----SEEAKLLLQQL----------SELESQ------L 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  242 AELQEKIQQTEATNKILQEKLNEMSYELkcaqeSSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREmlhqs 321
Cdd:COG3206   229 AEARAELAEAEARLAALRAQLGSGPDAL-----PELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRA----- 298
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  322 qlgQLHSSEGTSPAQQQVALLDLQSalfcsqlEIQKLQRVVRQKERQLADAKQcvQFVEAAAHESEQQKeaswkHNQELr 401
Cdd:COG3206   299 ---QIAALRAQLQQEAQRILASLEA-------ELEALQAREASLQAQLAQLEA--RLAELPELEAELRR-----LEREV- 360
                         250       260
                  ....*....|....*....|....*....
gi 525313637  402 KALQQLQEELQNKSQQLRAWEAEKYNEIR 430
Cdd:COG3206   361 EVARELYESLLQRLEEARLAEALTVGNVR 389
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1844-2025 3.23e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.08  E-value: 3.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLshvsr 1923
Cdd:COG1196   339 LEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALL----- 413
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1924 ehsQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQ 2003
Cdd:COG1196   414 ---ERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAA 490
                         170       180
                  ....*....|....*....|..
gi 525313637 2004 QLFESLQSELQIYEALYGNSKK 2025
Cdd:COG1196   491 ARLLLLLEAEADYEGFLEGVKA 512
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
398-933 3.49e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 3.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  398 QELRKALQQLQEELQNKSQQLRAWE-----AEKYNEIRTQEQNIQHLNHSLSH--KEQLLQEFRELLQYRDNSDKTLEAN 470
Cdd:COG4913   231 VEHFDDLERAHEALEDAREQIELLEpirelAERYAAARERLAELEYLRAALRLwfAQRRLELLEAELEELRAELARLEAE 310
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  471 EMLLEKLRQRIHDKAVALERAIDE-KFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVE 549
Cdd:COG4913   311 LERLEARLDALREELDELEAQIRGnGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAA 390
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  550 QLSTTCQNLQwlkEEMETKFSRWQKEqesiIQQLQTSLHDRNKEVEDLSATLLCkLGPGQSEIAEELCQRLQRKERMLQ- 628
Cdd:COG4913   391 ALLEALEEEL---EALEEALAEAEAA----LRDLRRELRELEAEIASLERRKSN-IPARLLALRDALAEALGLDEAELPf 462
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  629 --DLLsdrnkQVLEHEME----IQGLLQSVSTR-----EQESQAAA--------EKLV-QALMERNSELQA--------- 679
Cdd:COG4913   463 vgELI-----EVRPEEERwrgaIERVLGGFALTllvppEHYAAALRwvnrlhlrGRLVyERVRTGLPDPERprldpdsla 537
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  680 -------------LRQYLGGRDSLM---SQAPISNQQAEVTPTGrLGKQtdqgsmqipsrddSTSLTAKEDVSIPRST-- 741
Cdd:COG4913   538 gkldfkphpfrawLEAELGRRFDYVcvdSPEELRRHPRAITRAG-QVKG-------------NGTRHEKDDRRRIRSRyv 603
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  742 LGD--LDTVAGLEKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAA--DMESLTRNIQIKEDLIKDLQmq 817
Cdd:COG4913   604 LGFdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDeiDVASAEREIAELEAELERLD-- 681
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  818 lvdpEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQqlllmlegLVDERSRLNEALQAERQLYSSLVKFHAHPESS 897
Cdd:COG4913   682 ----ASSDDLAALEEQLEELEAELEELEEELDELKGEIGR--------LEKELEQAEEELDELQDRLEAAEDLARLELRA 749
                         570       580       590
                  ....*....|....*....|....*....|....*...
gi 525313637  898 ERDRTLQVELEGAQV--LRSRLEEVLGRSLERLNRLET 933
Cdd:COG4913   750 LLEERFAAALGDAVEreLRENLEERIDALRARLNRAEE 787
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1841-2060 3.52e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1841 ADLLEEHLGEIRNLRQRLEesicindRLREQLEHrltstargrgstsnfysqgLESIPQLCNENRVLREDNRRLQAQLSH 1920
Cdd:COG4913   227 ADALVEHFDDLERAHEALE-------DAREQIEL-------------------LEPIRELAERYAAARERLAELEYLRAA 280
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1921 VSREHSQ-ETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEvlhfreerlsLQEND----SRLQHKLVLL 1995
Cdd:COG4913   281 LRLWFAQrRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQ----------IRGNGgdrlEQLEREIERL 350
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 525313637 1996 QQQCEEKQQLFESLQSELQIYEALYGNSKKGLKAYS------LDACHQI--PLSSDLSHLVAEVRALRGQLEQ 2060
Cdd:COG4913   351 ERELEERERRRARLEALLAALGLPLPASAEEFAALRaeaaalLEALEEEleALEEALAEAEAALRDLRRELRE 423
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
356-577 4.40e-04

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 44.75  E-value: 4.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   356 QKLQRVVRQKERQLADAKqcvqfvEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEkyneirTQEQN 435
Cdd:pfam09787   14 QKAARILQSKEKLIASLK------EGSGVEGLDSSTALTLELEELRQERDLLREEIQKLRGQIQQLRTE------LQELE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   436 IQHLNHSLSHKEQLlQEFRELLQYRDNSDKTLEANemlLEKLRQRIHdkavaleraidekfSALEEKEKELRQLRLAVRE 515
Cdd:pfam09787   82 AQQQEEAESSREQL-QELEEQLATERSARREAEAE---LERLQEELR--------------YLEEELRRSKATLQSRIKD 143
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 525313637   516 RDHDLERLRDVL---SSNEATMQSMESLLR-------AKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQE 577
Cdd:pfam09787  144 REAEIEKLRNQLtskSQSSSSQSELENRLHqltetliQKQTMLEALSTEKNSLVLQLERMEQQIKELQGEGS 215
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
385-536 5.57e-04

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 43.36  E-value: 5.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   385 ESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKY------NEIRTQEQNIQHLNHslsHKEQLLQEFRELLQ 458
Cdd:pfam13851   44 RNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLENYEKDKQslknlkARLKVLEKELKDLKW---EHEVLEQRFEKVER 120
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   459 YRDNsdkTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL----ERLRDVLSSNEATM 534
Cdd:pfam13851  121 ERDE---LYDKFEAAIQDVQQKTGLKNLLLEKKLQALGETLEKKEAQLNEVLAAANLDPDALqavtEKLEDVLESKNQLI 197

                   ..
gi 525313637   535 QS 536
Cdd:pfam13851  198 KD 199
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
8-300 6.97e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.06  E-value: 6.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637     8 LSQHLNDLKKENFSLKLRIyfleERMQQKYEASREDIYkrniELKVEVESLKRELQDKKQHLDKTWADVEnlnsqneaEL 87
Cdd:TIGR02169  707 LSQELSDASRKIGEIEKEI----EQLEQEEEKLKERLE----ELEEDLSSLEQEIENVKSELKELEARIE--------EL 770
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    88 RRQFEERQQETEHVY-ELLENKIQLLQEESRLAKNEAARM-AALVEAEKECNLELSEKlkgvTKNWEDVPGDQVKPDQYT 165
Cdd:TIGR02169  771 EEDLHKLEEALNDLEaRLSHSRIPEIQAELSKLEEEVSRIeARLREIEQKLNRLTLEK----EYLEKEIQELQEQRIDLK 846
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   166 EALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEpTSMEVQPMTEELLK-QQKLNSHETTITQQsvsDSHLAEL 244
Cdd:TIGR02169  847 EQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGD-LKKERDELEAQLRElERKIEELEAQIEKK---RKRLSEL 922
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 525313637   245 QEKIQQTEATNKILQEKLNEMSYELKCaqessqkqDGTIQNLKETLKSRERETEEL 300
Cdd:TIGR02169  923 KAKLEALEEELSEIEDPKGEDEEIPEE--------ELSLEDVQAELQRVEEEIRAL 970
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1841-2060 7.53e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.05  E-value: 7.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1841 ADLLEEHLGEIRNLRQRLEESICINDRLREQLEhRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSH 1920
Cdd:TIGR02168  704 RKELEELEEELEQLRKELEELSRQISALRKDLA-RLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEA 782
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1921 VSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCE 2000
Cdd:TIGR02168  783 EIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIE 862
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  2001 EKQQLFESLQSELQIYEALYGNSKKGLKAYSLDachQIPLSSDLSHLVAEVRALRGQLEQ 2060
Cdd:TIGR02168  863 ELEELIEELESELEALLNERASLEEALALLRSE---LEELSEELRELESKRSELRRELEE 919
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
333-516 8.43e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 43.37  E-value: 8.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  333 SPAQQQVALLDLQSALfcsqLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEaswkhnqELRKALQQLQEELQ 412
Cdd:COG1579     1 AMPEDLRALLDLQELD----SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELE-------DLEKEIKRLELEIE 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  413 NKSQQLRAWEaEKYNEIRTQEQnIQHLNHSLSH----KEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIhdkaVAL 488
Cdd:COG1579    70 EVEARIKKYE-EQLGNVRNNKE-YEALQKEIESlkrrISDLEDEILELMERIEELEEELAELEAELAELEAEL----EEK 143
                         170       180
                  ....*....|....*....|....*...
gi 525313637  489 ERAIDEKFSALEEKEKELRQLRLAVRER 516
Cdd:COG1579   144 KAELDEELAELEAELEELEAEREELAAK 171
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
7-528 8.70e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 44.73  E-value: 8.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637     7 TLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIyKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNsQNEAE 86
Cdd:pfam05557   38 ALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQA-ELNRLKKKYLEALNKKLNEKESQLADAREVISCLK-NELSE 115
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    87 LRRQFEERQQETEHvyelLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVtKNWEDVPGDQVKPDQYTE 166
Cdd:pfam05557  116 LRRQIQRAELELQS----TNSELEELQERLDLLKAKASEAEQLRQNLEKQQSSLAEAEQRI-KELEFEIQSQEQDSEIVK 190
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   167 ALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSME-----VQPMTEELLK--------QQKLNSHETTITQ 233
Cdd:pfam05557  191 NSKSELARIPELEKELERLREHNKHLNENIENKLLLKEEVEDLKrklerEEKYREEAATlelekeklEQELQSWVKLAQD 270
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   234 QSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELK----CAQESSQKQDGTIQNLKETLKSREReTEELYQVIEGQND 309
Cdd:pfam05557  271 TGLNLRSPEDLSRRIEQLQQREIVLKEENSSLTSSARqlekARRELEQELAQYLKKIEDLNKKLKR-HKALVRRLQRRVL 349
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   310 TMAKLREMLHQ------SQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQklqrvVRQKERQLADAKQCVQFVEA-- 381
Cdd:pfam05557  350 LLTKERDGYRAilesydKELTMSNYSPQLLERIEEAEDMTQKMQAHNEEMEAQ-----LSVAEEELGGYKQQAQTLERel 424
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   382 -AAHESEQQKEASWKHNQ--ELRKALQQLQEELQNKSQQLRAWEAEkyneirTQEQNIQHLNHSLSHKEQLLQEfRELLQ 458
Cdd:pfam05557  425 qALRQQESLADPSYSKEEvdSLRRKLETLELERQRLREQKNELEME------LERRCLQGDYDPKKTKVLHLSM-NPAAE 497
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   459 YRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLS 528
Cdd:pfam05557  498 AYQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLPETTSTMNFKEVLDLRKELESAELKNQRLKEVFQ 567
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
227-693 9.07e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.43  E-value: 9.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   227 HETTITQQSVSDSH-------LAELQEKIQQTEATNKILQEKLNEMSyelkcAQESSQKQDgtIQNLKETLKSRERETEE 299
Cdd:pfam10174  270 REEEIKQMEVYKSHskfmknkIDQLKQELSKKESELLALQTKLETLT-----NQNSDCKQH--IEVLKESLTAKEQRAAI 342
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   300 LYQVIEGQNDTMAKLREMLH--QSQLGQLHSSEGTspaqQQVALLDLQSALFCS-------QLEIQKLQRVVRQKERQLA 370
Cdd:pfam10174  343 LQTEVDALRLRLEEKESFLNkkTKQLQDLTEEKST----LAGEIRDLKDMLDVKerkinvlQKKIENLQEQLRDKDKQLA 418
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   371 DAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLL 450
Cdd:pfam10174  419 GLKERVKSLQTDSSNTDTALTTLEEALSEKERIIERLKEQREREDRERLEELESLKKENKDLKEKVSALQPELTEKESSL 498
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   451 QEFRELLQ-------YRDNSDKTLEAN-------EMLLEKLRQRIHDKAVAlERAIDEKFSALEEKEKELRQLRLAVRER 516
Cdd:pfam10174  499 IDLKEHASslassglKKDSKLKSLEIAveqkkeeCSKLENQLKKAHNAEEA-VRTNPEINDRIRLLEQEVARYKEESGKA 577
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   517 DHDLERLRDVL-------SSNEATMQSMESLLRAKGLEveqLSTTCQNLQWLKEEMETKfsrwqkeqesIIQQLQTSLHD 589
Cdd:pfam10174  578 QAEVERLLGILrevenekNDKDKKIAELESLTLRQMKE---QNKKVANIKHGQQEMKKK----------GAQLLEEARRR 644
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   590 RNKEVEDLSATLLCKLGPGQSEIAEEL----------CQRLQRKERMLQDLLSDRNKQVLEH-EMEIQGLLQSVStrEQE 658
Cdd:pfam10174  645 EDNLADNSQQLQLEELMGALEKTRQELdatkarlsstQQSLAEKDGHLTNLRAERRKQLEEIlEMKQEALLAAIS--EKD 722
                          490       500       510
                   ....*....|....*....|....*....|....*.
gi 525313637   659 SQAAAEKLVQALMERNS-ELQALRQYlggRDSLMSQ 693
Cdd:pfam10174  723 ANIALLELSSSKKKKTQeEVMALKRE---KDRLVHQ 755
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
1-305 9.44e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 44.56  E-value: 9.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    1 MSNGYRTLSQHLNDLKKENFSLKlriyflEERMQQKYEAsrediykrNIELKVEVESLKRELQDKKQHLDKTWADVENLN 80
Cdd:COG5185   251 TSDKLEKLVEQNTDLRLEKLGEN------AESSKRLNEN--------ANNLIKQFENTKEKIAEYTKSIDIKKATESLEE 316
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   81 SQNEAELRRQFEERQQETEHvyELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLE-LSEKLKGVTKNWEDVPgdQV 159
Cdd:COG5185   317 QLAAAEAEQELEESKRETET--GIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELSkSSEELDSFKDTIESTK--ES 392
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  160 KPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEpTSMEVQPMTEELLKQQKLNSHETTITQQSVSDS 239
Cdd:COG5185   393 LDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQATSSNEE-VSKLLNELISELNKVMREADEESQSRLEEAYDE 471
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  240 HLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNL----KETLKSRERETEELYQVIE 305
Cdd:COG5185   472 INRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLERQLEGVRSKldqvAESLKDFMRARGYAHILAL 541
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
42-597 1.03e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   42 EDIYKRNIELKVEVESLkRELQDKKQHLDKTWADvenLNSQNEAELRRQFEERQQEtehvYELLENKIQLLQEEsrLAKN 121
Cdd:COG4913   238 ERAHEALEDAREQIELL-EPIRELAERYAAARER---LAELEYLRAALRLWFAQRR----LELLEAELEELRAE--LARL 307
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  122 EAARmaALVEAEKEcnlELSEKLKGVTKNWEDVPGDQVkpdqytEALAQrdkRIEELNQSLAAQERLVEQLsrekQQLLH 201
Cdd:COG4913   308 EAEL--ERLEARLD---ALREELDELEAQIRGNGGDRL------EQLER---EIERLERELEERERRRARL----EALLA 369
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  202 LLEEPTsmevqPMTEELLKQQKLNSHEttitQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKcAQESSQKQ-D 280
Cdd:COG4913   370 ALGLPL-----PASAEEFAALRAEAAA----LLEALEEELEALEEALAEAEAALRDLRRELRELEAEIA-SLERRKSNiP 439
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  281 GTIQNLKETLKS--RERETE-----ELYQVIEGQND--------------TM-------AKLREMLHQSQLGQLHSSEGT 332
Cdd:COG4913   440 ARLLALRDALAEalGLDEAElpfvgELIEVRPEEERwrgaiervlggfalTLlvppehyAAALRWVNRLHLRGRLVYERV 519
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  333 SPAQQQVALLDLQSALFCSQLEIQK------LQRVVRQK--------ERQLADAKQCV-------QFVEAAAHESEQQKE 391
Cdd:COG4913   520 RTGLPDPERPRLDPDSLAGKLDFKPhpfrawLEAELGRRfdyvcvdsPEELRRHPRAItragqvkGNGTRHEKDDRRRIR 599
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  392 ASWKHNQELRKALQQLQEELQNKSQQLRAWEAEkYNEIRTQEQNIQhlnhslshkeQLLQEFRELLQYRDNSDKTLEANE 471
Cdd:COG4913   600 SRYVLGFDNRAKLAALEAELAELEEELAEAEER-LEALEAELDALQ----------ERREALQRLAEYSWDEIDVASAER 668
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  472 ML--LEKLRQRI---HDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAkgL 546
Cdd:COG4913   669 EIaeLEAELERLdasSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARL--E 746
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 525313637  547 EVEQLSTTCQNLqwLKEEMETKFSRWQKEQesiIQQLQTSLHDRNKEVEDL 597
Cdd:COG4913   747 LRALLEERFAAA--LGDAVERELRENLEER---IDALRARLNRAEEELERA 792
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1844-2014 1.62e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.90  E-value: 1.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGS-----------------TSNFYSQGLESI--------- 1897
Cdd:TIGR02169  714 ASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENvkselkelearieeleeDLHKLEEALNDLearlshsri 793
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1898 PQLCNENRVLREDNRRLQAQLSHVSREHSQETEsLREALLSSRSHLQELEKELEHQKVERQQLLEDLR-----------E 1966
Cdd:TIGR02169  794 PEIQAELSKLEEEVSRIEARLREIEQKLNRLTL-EKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNgkkeeleeeleE 872
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 525313637  1967 KQQEVLHFREERLSLQENDSRLQHKLVLLQ---QQCEEKQQLFESLQSELQ 2014
Cdd:TIGR02169  873 LEAALRDLESRLGDLKKERDELEAQLRELErkiEELEAQIEKKRKRLSELK 923
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1905-2014 1.76e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.77  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1905 RVLREDNRRLQAQL-SHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLLEDLREKQQEVLHFREERLSLQE 1983
Cdd:COG1196   216 RELKEELKELEAELlLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLA 295
                          90       100       110
                  ....*....|....*....|....*....|.
gi 525313637 1984 NDSRLQHKLVLLQQQCEEKQQLFESLQSELQ 2014
Cdd:COG1196   296 ELARLEQDIARLEERRRELEERLEELEEELA 326
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
739-1123 2.02e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.51  E-value: 2.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   739 RSTLGDLDTVAGLEKELSNAKEELELMAKKE---RESQMELSALQsmmavqeeeLQVQAADMESLTRNIQIKEDLIKDLQ 815
Cdd:TIGR02168  182 ERTRENLDRLEDILNELERQLKSLERQAEKAeryKELKAELRELE---------LALLVLRLEELREELEELQEELKEAE 252
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   816 MQLVDPEdiPAMERLTQEVLLLREKVASVESQGQEISGNrrqqlllmLEGLVDERSRLNEALQaerqlysslvkfhahpE 895
Cdd:TIGR02168  253 EELEELT--AELQELEEKLEELRLEVSELEEEIEELQKE--------LYALANEISRLEQQKQ----------------I 306
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   896 SSERDRTLQVELEGAQVLRSRLEEVLGRSLERLNRLEtlaaiggaaagddteDTSTEFTDSIEEEAAHHSHQQLVKVALE 975
Cdd:TIGR02168  307 LRERLANLERQLEELEAQLEELESKLDELAEELAELE---------------EKLEELKEELESLEAELEELEAELEELE 371
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   976 KSLATvetqnpsfsppspmggdsnrcLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQIEEAGFS-SVSHIRNTMLSLCL 1054
Cdd:TIGR02168  372 SRLEE---------------------LEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRrERLQQEIEELLKKL 430
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 525313637  1055 ENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSEsSLQAEFRKLQGKLKNAHNIINLLKEQL 1123
Cdd:TIGR02168  431 EEAELKELQAELEELEEELEELQEELERLEEALEELREELE-EAEQALDAAERELAQLQARLDSLERLQ 498
PLN02939 PLN02939
transferase, transferring glycosyl groups
377-668 2.19e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.35  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  377 QFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNksqqlraweAEK----YNEIRTQEqnIQHLNHSLSHKEQLLQE 452
Cdd:PLN02939  103 QRDEAIAAIDNEQQTNSKDGEQLSDFQLEDLVGMIQN---------AEKnillLNQARLQA--LEDLEKILTEKEALQGK 171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  453 FREL---LQYRDNSDKT-------LEANEMLLEKLRQRIHDKAV---ALERAIDEKFSALEEKEKELRQLRLAVR----- 514
Cdd:PLN02939  172 INILemrLSETDARIKLaaqekihVEILEEQLEKLRNELLIRGAtegLCVHSLSKELDVLKEENMLLKDDIQFLKaelie 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  515 -----ERDHDLERLRDVLssnEATMQSMESLLRAKGLEVEQLSTTCQNLQWLK-EEMETKFSRWQKEQESIIQQLQTSlH 588
Cdd:PLN02939  252 vaeteERVFKLEKERSLL---DASLRELESKFIVAQEDVSKLSPLQYDCWWEKvENLQDLLDRATNQVEKAALVLDQN-Q 327
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  589 DRNKEVEDLSATLlckLGPGQSEIAEELCQRLQRKERMLQDLLsdrnkQVLEHEMEIQGLLQSVSTreQESQAAAEKLVQ 668
Cdd:PLN02939  328 DLRDKVDKLEASL---KEANVSKFSSYKVELLQQKLKLLEERL-----QASDHEIHSYIQLYQESI--KEFQDTLSKLKE 397
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
447-677 2.23e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.37  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  447 EQLLQEFRELLQYRDNSDKTLEANEML--LEKLRQRIHDKAVALE--RAIDEKFS------ALEEKEKELRQLRLAVRER 516
Cdd:COG4913   228 DALVEHFDDLERAHEALEDAREQIELLepIRELAERYAAARERLAelEYLRAALRlwfaqrRLELLEAELEELRAELARL 307
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  517 DHDLERLRDVLSSNEATMQSMESLLRAKGLE-VEQLSttcQNLQWLKEEMETKFSRWQkEQESIIQQLQTSLHDRNKEVE 595
Cdd:COG4913   308 EAELERLEARLDALREELDELEAQIRGNGGDrLEQLE---REIERLERELEERERRRA-RLEALLAALGLPLPASAEEFA 383
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  596 DLSATLlcklgPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNS 675
Cdd:COG4913   384 ALRAEA-----AALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALAEALGLDEA 458

                  ..
gi 525313637  676 EL 677
Cdd:COG4913   459 EL 460
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
84-666 2.42e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 43.24  E-value: 2.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    84 EAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEkecnlELSEKLKGVTKNWEDVPGDqvkpdq 163
Cdd:pfam01576   11 EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAE-----EMRARLAARKQELEEILHE------ 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   164 yteaLAQRDKRIEELNQSLAAQERlveqlsrEKQQLLHLLEEPtsmevqpMTEELLKQQKLNSHETTItqqsvsDSHLAE 243
Cdd:pfam01576   80 ----LESRLEEEEERSQQLQNEKK-------KMQQHIQDLEEQ-------LDEEEAARQKLQLEKVTT------EAKIKK 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   244 LQEKIQQTEATN-------KILQEKLNEMSYELKCAQESSQ-------KQDGTIQNLKETLKSRE---RETEELYQVIEG 306
Cdd:pfam01576  136 LEEDILLLEDQNsklskerKLLEERISEFTSNLAEEEEKAKslsklknKHEAMISDLEERLKKEEkgrQELEKAKRKLEG 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   307 QndtmaklremlhqsqlgqlhssegTSPAQQQVALLdlqsalfcsQLEIQKLQRVVRQKERQLADAkqcvqfvEAAAHES 386
Cdd:pfam01576  216 E------------------------STDLQEQIAEL---------QAQIAELRAQLAKKEEELQAA-------LARLEEE 255
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   387 EQQKEASWKHNQELRKALQQLQEELQ------NKSQQLRAWEAEKYNEIRTQ------------------EQNIQHLNHS 442
Cdd:pfam01576  256 TAQKNNALKKIRELEAQISELQEDLEseraarNKAEKQRRDLGEELEALKTEledtldttaaqqelrskrEQEVTELKKA 335
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   443 LSHK----EQLLQEFREllqyrdnsdKTLEANEMLLEKLRQRIHDKAvALERAIDEKFSALEEKEKELRQLRLAVRERDH 518
Cdd:pfam01576  336 LEEEtrshEAQLQEMRQ---------KHTQALEELTEQLEQAKRNKA-NLEKAKQALESENAELQAELRTLQQAKQDSEH 405
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   519 DLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQT------------- 585
Cdd:pfam01576  406 KRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDtqellqeetrqkl 485
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   586 SLHDRNKEVEDLSATLLcklgpGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGL----------LQSVSTR 655
Cdd:pfam01576  486 NLSTRLRQLEDERNSLQ-----EQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALeegkkrlqreLEALTQQ 560
                          650
                   ....*....|.
gi 525313637   656 EQESQAAAEKL 666
Cdd:pfam01576  561 LEEKAAAYDKL 571
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
8-285 2.58e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 42.92  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637    8 LSQHLNDLKKEnFSLKLRIYFLEERMQQKYEASREDIYKRNIE-------LKVEVESLKRE-------------LQDKKQ 67
Cdd:PLN03229  460 LNEMIEKLKKE-IDLEYTEAVIAMGLQERLENLREEFSKANSQdqlmhpvLMEKIEKLKDEfnkrlsrapnylsLKYKLD 538
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   68 HLDKTWADVENLNSQNEAE-LRRQFEERQQETEHVYELLEnKIQLLQEEsrLAKNEAARMAAL--------VEAEKECNL 138
Cdd:PLN03229  539 MLNEFSRAKALSEKKSKAEkLKAEINKKFKEVMDRPEIKE-KMEALKAE--VASSGASSGDELdddlkekvEKMKKEIEL 615
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  139 ELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKrIEELNqslaaqerlvEQLSREKQQLLHlleeptSMEVQPMTEEL 218
Cdd:PLN03229  616 ELAGVLKSMGLEVIGVTKKNKDTAEQTPPPNLQEK-IESLN----------EEINKKIERVIR------SSDLKSKIELL 678
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  219 lkqqKLNSHETTITQQSVSDSHLAELQEKIQQ--TEATNKI-LQEKLNEMSYELKCAQESSQKQDGTIQN 285
Cdd:PLN03229  679 ----KLEVAKASKTPDVTEKEKIEALEQQIKQkiAEALNSSeLKEKFEELEAELAAARETAAESNGSLKN 744
HAUS5 pfam14817
HAUS augmin-like complex subunit 5; This family includes HAUS augmin-like complex subunit 5. ...
1899-1983 2.87e-03

HAUS augmin-like complex subunit 5; This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis.


Pssm-ID: 464332 [Multi-domain]  Cd Length: 643  Bit Score: 42.73  E-value: 2.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1899 QLCNENRVLREDNRRLQAQL----------SHVSREHSQETESLREA---------LLSSRSHLQELEKELEHQKVERQQ 1959
Cdd:pfam14817  317 QFLNELAETRSRCQQLQARLqglkdeaeleSLGIGDTSQNDSLLRQVlelelqaagLAASRDTLRSECQQLNKLARERQE 396
                           90       100
                   ....*....|....*....|....
gi 525313637  1960 LLEDLREKQQEVLHFREERLSLQE 1983
Cdd:pfam14817  397 ALRSLQKKWQRILDFRQLVSELQE 420
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
738-932 3.05e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 3.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  738 PRSTLGDLDTVAGLEKELSNAKEELELmAKKERESQMELSALQSMMAVQEEELQVQAADMESLT-----RNIQIKEDLIK 812
Cdd:COG4913   220 EPDTFEAADALVEHFDDLERAHEALED-AREQIELLEPIRELAERYAAARERLAELEYLRAALRlwfaqRRLELLEAELE 298
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  813 DLQMQLVDPEDipAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERSRLNEALQAERQLYSSLvkfHA 892
Cdd:COG4913   299 ELRAELARLEA--ELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAAL---GL 373
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 525313637  893 HPESSERD-----RTLQVELEGAQVLRSRLEEVLGRSLERLNRLE 932
Cdd:COG4913   374 PLPASAEEfaalrAEAAALLEALEEELEALEEALAEAEAALRDLR 418
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
408-682 3.42e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.85  E-value: 3.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   408 QEELQNKSQQLRAWEaEKYNEIRTQEQNIQHLNHSLSHKEQLLQEfrellQYRDNSDKTLEANEMlleklRQRIHDKAVA 487
Cdd:pfam01576    4 EEEMQAKEEELQKVK-ERQQKAESELKELEKKHQQLCEEKNALQE-----QLQAETELCAEAEEM-----RARLAARKQE 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   488 LERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMEsllrakgLEVEQLSTTCQNLQ---WLKEE 564
Cdd:pfam01576   73 LEEILHELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQ-------LEKVTTEAKIKKLEediLLLED 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   565 METKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSatllcKLGPGQSEIAEELCQRLQRKERMLQDL----------LSDR 634
Cdd:pfam01576  146 QNSKLSKERKLLEERISEFTSNLAEEEEKAKSLS-----KLKNKHEAMISDLEERLKKEEKGRQELekakrklegeSTDL 220
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 525313637   635 NKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQ 682
Cdd:pfam01576  221 QEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRE 268
PRK11281 PRK11281
mechanosensitive channel MscK;
368-684 3.66e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  368 QLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQlraweaekyneIRTQEQNIQHLNHSLSHKE 447
Cdd:PRK11281   25 AFARAASNGDLPTEADVQAQLDALNKQKLLEAEDKLVQQDLEQTLALLDK-----------IDRQKEETEQLKQQLAQAP 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  448 QLLQEF-RELLQYRDNSDKTLEANemlLEKLRQRihdkavALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDV 526
Cdd:PRK11281   94 AKLRQAqAELEALKDDNDEETRET---LSTLSLR------QLESRLAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQAA 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  527 LSSNEATMQSMESLLRAKGLEVEQLSTTCQNLqwlkeemetkfsrWQKEQESIiqQLQTSLhdRNKEVEdlSATLLCKLG 606
Cdd:PRK11281  165 LYANSQRLQQIRNLLKGGKVGGKALRPSQRVL-------------LQAEQALL--NAQNDL--QRKSLE--GNTQLQDLL 225
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 525313637  607 PGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMeiqgllQSVSTREQESQAAAEKLVQALMERNSELQalrQYL 684
Cdd:PRK11281  226 QKQRDYLTARIQRLEHQLQLLQEAINSKRLTLSEKTV------QEAQSQDEAARIQANPLVAQELEINLQLS---QRL 294
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
226-1051 4.71e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.52  E-value: 4.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   226 SHETTI-TQQSVSDSHLAELQEKIQQTEATnkiLQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQvi 304
Cdd:pfam12128  269 SDETLIaSRQEERQETSAELNQLLRTLDDQ---WKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAA-- 343
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   305 egqndtmaklremLHQSQLGQLHSSegtspaqqqvalLDLQSALFCSQLEiqKLQRVVRQKERQLADAK-QCVQFVEAAA 383
Cdd:pfam12128  344 -------------ADQEQLPSWQSE------------LENLEERLKALTG--KHQDVTAKYNRRRSKIKeQNNRDIAGIK 396
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   384 HESEQQKEASWKHNQELRKALQQLQEEL--QNKSQQLRAWEAEKYNEIRTQEQNIQhLNHSLSHKEQLLQefrellqyrd 461
Cdd:pfam12128  397 DKLAKIREARDRQLAVAEDDLQALESELreQLEAGKLEFNEEEYRLKSRLGELKLR-LNQATATPELLLQ---------- 465
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   462 nsdktLEANEMLLEKLRQrihdkavALERAidekFSALEEKEKELRQLRLAvreRDHDLERLRD----VLSSNEATMQSM 537
Cdd:pfam12128  466 -----LENFDERIERARE-------EQEAA----NAEVERLQSELRQARKR---RDQASEALRQasrrLEERQSALDELE 526
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   538 ESLLRAKGLEVEQLSTTCQNlqwlkeemetkfsrWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLG----------- 606
Cdd:pfam12128  527 LQLFPQAGTLLHFLRKEAPD--------------WEQSIGKVISPELLHRTDLDPEVWDGSVGGELNLYgvkldlkridv 592
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   607 PGQSEIAEELCQRLQRKERMLQDlLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLgg 686
Cdd:pfam12128  593 PEWAASEEELRERLDKAEEALQS-AREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKK-- 669
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   687 rdslmSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEdvsiprSTLGDLDTVAGLEKELSNAKEEL-ELM 765
Cdd:pfam12128  670 -----NKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKRE------ARTEKQAYWQVVEGALDAQLALLkAAI 738
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   766 AKKERESQMELSALQSMMAvqeEELQVQAADMESLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLR-----EK 840
Cdd:pfam12128  739 AARRSGAKAELKALETWYK---RDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEVLRYFDWYQETWLQRrprlaTQ 815
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   841 VASVESQGQEISGN----------RRQQLLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGA 910
Cdd:pfam12128  816 LSNIERAISELQQQlarliadtklRRAKLEMERKASEKQQVRLSENLRGLRCEMSKLATLKEDANSEQAQGSIGERLAQL 895
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   911 QVLRSRLEEVLGRSLERLNRLETLAAIGGAAAGDdtedtstEFTDSIEEEAAHHSHQQLVKVALEKSLATVEtqnPSFSP 990
Cdd:pfam12128  896 EDLKLKRDYLSESVKKYVEHFKNVIADHSGSGLA-------ETWESLREEDHYQNDKGIRLLDYRKLVPYLE---QWFDV 965
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 525313637   991 PSPMGGDSNRCLQEEMLHLRAEFHQHLEE-KRKAEEELKELKAQI-EEAGFSSVSHIRNTMLS 1051
Cdd:pfam12128  966 RVPQSIMVLREQVSILGVDLTEFYDVLADfDRRIASFSRELQREVgEEAFFEGVSESAVRIRS 1028
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
335-928 5.55e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 5.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  335 AQQQVALLDLQSALFcSQLEIQKLQRVVRQKERQLADAkqcvqfvEAAAHESEQQKEAswkHNQELRKALQQLQeelQNK 414
Cdd:COG4913   271 LAELEYLRAALRLWF-AQRRLELLEAELEELRAELARL-------EAELERLEARLDA---LREELDELEAQIR---GNG 336
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  415 SQQLRAWEAEkyneirtqeqnIQHLNHSLSHKEQLLQEFRELLQyrdNSDKTLEANEMLLEKLRQRIHDKAVALERAIDE 494
Cdd:COG4913   337 GDRLEQLERE-----------IERLERELEERERRRARLEALLA---ALGLPLPASAEEFAALRAEAAALLEALEEELEA 402
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  495 KFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRakglevEQLSTTCQNLQWLKEEME--TKFSRW 572
Cdd:COG4913   403 LEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALA------EALGLDEAELPFVGELIEvrPEEERW 476
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  573 QKEQE---------------------SIIQQLQTSLH---------DRNKEVEDLSA-TLLCKL----GPGQSEIAEELC 617
Cdd:COG4913   477 RGAIErvlggfaltllvppehyaaalRWVNRLHLRGRlvyervrtgLPDPERPRLDPdSLAGKLdfkpHPFRAWLEAELG 556
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  618 QR-----------LQRKER--MLQDLLSDRNKQvleHEMEIQGLLQSV-----STREQ-----ESQAAAEKLVQALMERN 674
Cdd:COG4913   557 RRfdyvcvdspeeLRRHPRaiTRAGQVKGNGTR---HEKDDRRRIRSRyvlgfDNRAKlaaleAELAELEEELAEAEERL 633
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  675 SELQALRQYLGGRDSLMSQapISNQQAEvtptgrlgkqtdqgsmqipsrddstsltakedvsiprstlgDLDtVAGLEKE 754
Cdd:COG4913   634 EALEAELDALQERREALQR--LAEYSWD-----------------------------------------EID-VASAERE 669
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  755 LSNAKEELELMakkeRESQMELSALQSMMAVQEEELQVQAADMESLTRNI-----QIK--EDLIKDLQMQLVDPEDIPAm 827
Cdd:COG4913   670 IAELEAELERL----DASSDDLAALEEQLEELEAELEELEEELDELKGEIgrlekELEqaEEELDELQDRLEAAEDLAR- 744
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  828 erlTQEVLLLREKVAsvesqgQEISGNRRQQlllMLEGLVDERSRLNEAL-QAERQLYSSLVKFHAHPESSERDrtLQVE 906
Cdd:COG4913   745 ---LELRALLEERFA------AALGDAVERE---LRENLEERIDALRARLnRAEEELERAMRAFNREWPAETAD--LDAD 810
                         650       660
                  ....*....|....*....|..
gi 525313637  907 LEGAQVLRSRLEEVLGRSLERL 928
Cdd:COG4913   811 LESLPEYLALLDRLEEDGLPEY 832
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
414-964 5.56e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 42.12  E-value: 5.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   414 KSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEfrELLQYRDnsdktleanemllekLRQRIHDKAVALERAID 493
Cdd:pfam10174   43 KERALRKEEAARISVLKEQYRVTQEENQHLQLTIQALQD--ELRAQRD---------------LNQLLQQDFTTSPVDGE 105
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   494 EKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
Cdd:pfam10174  106 DKFSTPELTEENFRRLQSEHERQAKELFLLRKTLEEMELRIETQKQTLGARDESIKKLLEMLQSKGLPKKSGEEDWERTR 185
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   574 K--EQESIIQQLQTSLHDRNKEVEDLSATLLCKL-GPGQSEIAEELCQRLQRKERMLQDLlsDRNKQVLEHEMEI---QG 647
Cdd:pfam10174  186 RiaEAEMQLGHLEVLLDQKEKENIHLREELHRRNqLQPDPAKTKALQTVIEMKDTKISSL--ERNIRDLEDEVQMlktNG 263
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   648 LLQSVSTREQESQAAA------------EKLVQALMERNSELQALRQYLggrDSLMSQAPISNQQAEVTptgrlgkqtdq 715
Cdd:pfam10174  264 LLHTEDREEEIKQMEVykshskfmknkiDQLKQELSKKESELLALQTKL---ETLTNQNSDCKQHIEVL----------- 329
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   716 gsmqipsrddSTSLTAKEDVSIPRSTLGDLDTVAGLEKE--LSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQ 793
Cdd:pfam10174  330 ----------KESLTAKEQRAAILQTEVDALRLRLEEKEsfLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVL 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   794 AADMESLTRNIQIKEDLIKDLQ--MQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLllmleglvDERS 871
Cdd:pfam10174  400 QKKIENLQEQLRDKDKQLAGLKerVKSLQTDSSNTDTALTTLEEALSEKERIIERLKEQREREDRERL--------EELE 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   872 RLNEALQAERQLYSSLvkfhaHPESSERDRTLQVELEGAQVLRSR----------LEEVLGRSLERLNRLETlaAIGGAA 941
Cdd:pfam10174  472 SLKKENKDLKEKVSAL-----QPELTEKESSLIDLKEHASSLASSglkkdsklksLEIAVEQKKEECSKLEN--QLKKAH 544
                          570       580
                   ....*....|....*....|....*.
gi 525313637   942 AGDDTEDTSTEFTDSI---EEEAAHH 964
Cdd:pfam10174  545 NAEEAVRTNPEINDRIrllEQEVARY 570
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
1902-2017 6.03e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 40.27  E-value: 6.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  1902 NENRVLREDNRRLQAQLSHVSREHsQETESLREALLSSRSHLQEL--EKELEhqkvERQQLLEDLREKQQEVLHFREERL 1979
Cdd:pfam15619   67 EEVRVLRERLRRLQEKERDLERKL-KEKEAELLRLRDQLKRLEKLseDKNLA----EREELQKKLEQLEAKLEDKDEKIQ 141
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 525313637  1980 SLQE----NDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYE 2017
Cdd:pfam15619  142 DLERklelENKSFRRQLAAEKKKHKEAQEEVKILQEEIERLQ 183
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
471-682 7.44e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.54  E-value: 7.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  471 EMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRlavreRDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQ 550
Cdd:COG3206   163 EQNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFR-----QKNGLVDLSEEAKLLLQQLSELESQLAEARAELAE 237
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637  551 LSTTCQNLQWLKEEMETKFSRWQkeQESIIQQLQTSLHDRNKEVEDLSATLlcklGPGQSEIaeelcQRLQRKERMLQDL 630
Cdd:COG3206   238 AEARLAALRAQLGSGPDALPELL--QSPVIQQLRAQLAELEAELAELSARY----TPNHPDV-----IALRAQIAALRAQ 306
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 525313637  631 LSDRNKQVLEhemEIQGLLQSVSTREQESQAAAEKL---VQALMERNSELQALRQ 682
Cdd:COG3206   307 LQQEAQRILA---SLEAELEALQAREASLQAQLAQLearLAELPELEAELRRLER 358
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1844-2018 7.85e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 7.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSR 1923
Cdd:COG4942    32 LQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLR 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637 1924 EHSQETESLREALLSSRSHLQELEKELEHQKV---ERQQLLEDLREKQQEV----LHFREERLSLQENDSRLQHKLVLLQ 1996
Cdd:COG4942   112 ALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYlapARREQAEELRADLAELaalrAELEAERAELEALLAELEEERAALE 191
                         170       180
                  ....*....|....*....|..
gi 525313637 1997 QQCEEKQQLFESLQSELQIYEA 2018
Cdd:COG4942   192 ALKAERQKLLARLEKELAELAA 213
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
609-918 8.25e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.58  E-value: 8.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   609 QSEIAEELcQRLQRKERMLQ-DLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGR 687
Cdd:TIGR02168  208 QAEKAERY-KELKAELRELElALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEEL 286
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   688 DSLMSQapISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKedvsipRSTLGDLDTVAGLEKELSNAKEELELMAK 767
Cdd:TIGR02168  287 QKELYA--LANEISRLEQQKQILRERLANLERQLEELEAQLEELE------SKLDELAEELAELEEKLEELKEELESLEA 358
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   768 KERESQMELSALQSMMAVQEEELQVQAAD-------MESLTRNIQIKEDLIKDLQMQLvdpedipamERLTQEVLLLREK 840
Cdd:TIGR02168  359 ELEELEAELEELESRLEELEEQLETLRSKvaqlelqIASLNNEIERLEARLERLEDRR---------ERLQQEIEELLKK 429
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 525313637   841 VASVESQGQEISGNRRQQlllMLEGLVDERSRLNEALQAERQLYSslVKFHAHPESSERDRTLQVELEGAQVLRSRLE 918
Cdd:TIGR02168  430 LEEAELKELQAELEELEE---ELEELQEELERLEEALEELREELE--EAEQALDAAERELAQLQARLDSLERLQENLE 502
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
103-459 8.38e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 41.03  E-value: 8.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   103 ELLENKIQLLQEESR--LAKNEAARMAALVEAE--KECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEEL 178
Cdd:pfam07888   30 ELLQNRLEECLQERAelLQAQEAANRQREKEKEryKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSAS 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   179 NQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSH-ETTITQQSVSDSHLAELQEKIQQTEATNKI 257
Cdd:pfam07888  110 SEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERaKKAGAQRKEEEAERKQLQAKLQQTEEELRS 189
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   258 LQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEgqndTMAKLREMLHQSQ-----LGQLHSSEGT 332
Cdd:pfam07888  190 LSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLE----ELRSLQERLNASErkvegLGEELSSMAA 265
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525313637   333 SPAQQQVALLdlQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAahesEQQKEASWKHNQELRKALQQLQEElQ 412
Cdd:pfam07888  266 QRDRTQAELH--QARLQAAQLTLQLADASLALREGRARWAQERETLQQSA----EADKDRIEKLSAELQRLEERLQEE-R 338
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 525313637   413 NKSQQLRAWEAEKYNEIRTQ----EQNIQHLNHSL----SHKEQLLQEFRELLQY 459
Cdd:pfam07888  339 MEREKLEVELGREKDCNRVQlsesRRELQELKASLrvaqKEKEQLQAEKQELLEY 393
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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