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Conserved domains on  [gi|294712554|ref|NP_001171014|]
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KRAB box and zinc finger, C2H2 type domain containing [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.99e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 1.99e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 294712554    3 LVTYDDVHVNFTQDEWALLDPSQKSLYKGVMLETYKNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-486 6.63e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 6.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554  74 PSEFIQCGKAFAYESGRQRHQIKHNGEKHHDCNQCGKD--FRTWNVLQIHKRTHTGEKPYDC-KQCGKVFARSCHLQIHN 150
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 151 RTHAGEKQYECNQCGKAFKRRINLQIHKRTHTGEKPYECNQC-GKAFASSGELQKHKRTHTGEKPyeckqcgKAFSQSSH 229
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 230 LRIHKRTHTGEKPYECNQCGKAFARSGDLQKHKRTHTGEKPYECKQCGKAFAHS------SHLHKHERTHTGDKPYECKQ 303
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 304 CGKAFAVIYTLQMHKRTHTG-DKPYECKQCGKAFAVIYTLQMHKRT--HTGE--KPYKC--KQCGKAFARSCHLRIHKRT 376
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 377 HTGEKPYEC--NQCGKAFAESST-----LQIHNRTHTGEKPYEC--NQCGKAFITRRVLQIHKRTHTGEKPYECN--QCG 445
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 294712554 446 KAFARSCDLQKHKRTHTGEKPYECNHCGKAFAQSSSLRIHK 486
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.99e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 1.99e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 294712554    3 LVTYDDVHVNFTQDEWALLDPSQKSLYKGVMLETYKNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 5.23e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.94  E-value: 5.23e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 294712554     4 VTYDDVHVNFTQDEWALLDPSQKSLYKGVMLETYKNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 9.13e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.04  E-value: 9.13e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 294712554   4 VTYDDVHVNFTQDEWALLDPSQKSLYKGVMLETYKNLT 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-486 6.63e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 6.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554  74 PSEFIQCGKAFAYESGRQRHQIKHNGEKHHDCNQCGKD--FRTWNVLQIHKRTHTGEKPYDC-KQCGKVFARSCHLQIHN 150
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 151 RTHAGEKQYECNQCGKAFKRRINLQIHKRTHTGEKPYECNQC-GKAFASSGELQKHKRTHTGEKPyeckqcgKAFSQSSH 229
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 230 LRIHKRTHTGEKPYECNQCGKAFARSGDLQKHKRTHTGEKPYECKQCGKAFAHS------SHLHKHERTHTGDKPYECKQ 303
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 304 CGKAFAVIYTLQMHKRTHTG-DKPYECKQCGKAFAVIYTLQMHKRT--HTGE--KPYKC--KQCGKAFARSCHLRIHKRT 376
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 377 HTGEKPYEC--NQCGKAFAESST-----LQIHNRTHTGEKPYEC--NQCGKAFITRRVLQIHKRTHTGEKPYECN--QCG 445
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 294712554 446 KAFARSCDLQKHKRTHTGEKPYECNHCGKAFAQSSSLRIHK 486
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 2.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 294712554  201 ELQKHKRTHTGEKPYECKQCGKAFSQ 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.99e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 1.99e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 294712554    3 LVTYDDVHVNFTQDEWALLDPSQKSLYKGVMLETYKNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 5.23e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.94  E-value: 5.23e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 294712554     4 VTYDDVHVNFTQDEWALLDPSQKSLYKGVMLETYKNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 9.13e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.04  E-value: 9.13e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 294712554   4 VTYDDVHVNFTQDEWALLDPSQKSLYKGVMLETYKNLT 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-486 6.63e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 6.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554  74 PSEFIQCGKAFAYESGRQRHQIKHNGEKHHDCNQCGKD--FRTWNVLQIHKRTHTGEKPYDC-KQCGKVFARSCHLQIHN 150
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 151 RTHAGEKQYECNQCGKAFKRRINLQIHKRTHTGEKPYECNQC-GKAFASSGELQKHKRTHTGEKPyeckqcgKAFSQSSH 229
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 230 LRIHKRTHTGEKPYECNQCGKAFARSGDLQKHKRTHTGEKPYECKQCGKAFAHS------SHLHKHERTHTGDKPYECKQ 303
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 304 CGKAFAVIYTLQMHKRTHTG-DKPYECKQCGKAFAVIYTLQMHKRT--HTGE--KPYKC--KQCGKAFARSCHLRIHKRT 376
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 377 HTGEKPYEC--NQCGKAFAESST-----LQIHNRTHTGEKPYEC--NQCGKAFITRRVLQIHKRTHTGEKPYECN--QCG 445
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 294712554 446 KAFARSCDLQKHKRTHTGEKPYECNHCGKAFAQSSSLRIHK 486
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-497 9.41e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 9.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 198 SSGELQKHKRTHTGE----KPYECKQCGKAFSQSSHLRIHKRTHTGEKPYECNQ--CGKAFARSGDLQKHKRTHTGEKPY 271
Cdd:COG5048   13 NSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 272 ECKQCGKAFAHSSHLHKHERTHTGD-KPYECKQCGKAFAVIYTLQMHKRTHTGDKPYECKQCGKAFAVIYT--------- 341
Cdd:COG5048   93 LNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplp 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 342 -------------LQMHKRTHTGEKPYKCKQCGKAFARSCHLRIHKRTHTGEKPYECNQCGKAFAESSTLQIHNRT---- 404
Cdd:COG5048  173 anslskdpssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssd 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 405 --HTGEKPYECNQCGKAFITRRVLQIHKRTHTG-EKPYECNQCGKAFARSCDLQKHKRT--HTGE--KPYECNH--CGKA 475
Cdd:COG5048  253 ssSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKL 332

                        330       340
                 ....*....|....*....|..
gi 294712554 476 FAQSSSLRIHKRTYTGERQYEC 497
Cdd:COG5048  333 FSRNDALKRHILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-289 8.46e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 129 KPYDCKQCGKVFARSCHLQIHNRT--HAGE--KQYEC--NQCGKAFKRRINLQIHKRTHTGEKPYEC--NQCGKAF---- 196
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294712554 197 --ASSGELQKHKRTHTgEKPYEC--KQCGKAFSQSSHLRIHKRTHTGEKPYECN--QCGKAFARSGDLQKHKRTHTGEKP 270
Cdd:COG5048  368 nnEPPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170       180
                 ....*....|....*....|.
gi 294712554 271 YECKQCGK--AFAHSSHLHKH 289
Cdd:COG5048  447 LLCSILKSfrRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 2.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 294712554  201 ELQKHKRTHTGEKPYECKQCGKAFSQ 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-366 2.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.21e-04
                          10        20
                  ....*....|....*....|....*
gi 294712554  342 LQMHKRTHTGEKPYKCKQCGKAFAR 366
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 2.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.23e-04
                          10        20
                  ....*....|....*....|....*.
gi 294712554  257 DLQKHKRTHTGEKPYECKQCGKAFAH 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 3.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.54e-04
                          10        20
                  ....*....|....*....|....*.
gi 294712554  453 DLQKHKRTHTGEKPYECNHCGKAFAQ 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 4.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.40e-04
                          10        20
                  ....*....|....*....|....*.
gi 294712554  173 NLQIHKRTHTGEKPYECNQCGKAFAS 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-254 4.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 294712554  229 HLRIHKRTHTGEKPYECNQCGKAFAR 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-393 8.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.57e-04
                          10        20
                  ....*....|....*....|....*
gi 294712554  369 HLRIHKRTHTGEKPYECNQCGKAFA 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-337 1.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|....
gi 294712554  314 LQMHKRTHTGDKPYECKQCGKAFA 337
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-450 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*
gi 294712554  426 LQIHKRTHTGEKPYECNQCGKAFAR 450
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
437-498 3.51e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 3.51e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 294712554 437 KPYECNQCGKAFARSCDLQKHKRTHTGEKPYECNHCGKAFAQS--SSLRIHKRTYTGERQYECN 498
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 4.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|....*
gi 294712554  118 LQIHKRTHTGEKPYDCKQCGKVFAR 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-422 6.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.23e-03
                          10        20
                  ....*....|....*....|....*
gi 294712554  398 LQIHNRTHTGEKPYECNQCGKAFIT 422
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-309 8.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.53e-03
                          10        20
                  ....*....|....*....|..
gi 294712554  288 KHERTHTGDKPYECKQCGKAFA 309
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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