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Conserved domains on  [gi|289666734|ref|NP_001166238|]
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forkhead box protein P2 isoform VI [Homo sapiens]

Protein Classification

FOXP-CC domain-containing protein( domain architecture ID 11241229)

FOXP-CC domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FOXP-CC pfam16159
FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found ...
 367-434 4.54e-42

FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain


:

Pssm-ID: 465036  Cd Length: 68  Bit Score: 143.21  E-value: 4.54e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 289666734  367 LYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHL 434
Cdd:pfam16159   1 LFGHGVCRWPGCETVCEDFGSFLKHLNSEHALDDRSTAQCRVQMQVVQQLEIQLTKEKERLQAMMAHL 68
 
Name Accession Description Interval E-value
FOXP-CC pfam16159
FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found ...
 367-434 4.54e-42

FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain


Pssm-ID: 465036  Cd Length: 68  Bit Score: 143.21  E-value: 4.54e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 289666734  367 LYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHL 434
Cdd:pfam16159   1 LFGHGVCRWPGCETVCEDFGSFLKHLNSEHALDDRSTAQCRVQMQVVQQLEIQLTKEKERLQAMMAHL 68
 
Name Accession Description Interval E-value
FOXP-CC pfam16159
FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found ...
 367-434 4.54e-42

FOXP coiled-coil domain; This domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins in various Mammalia species. It is a coiled-coil domain, which modulates the dimeric associations of FOXP transcription factors. Several key disease mutations, for instance those found in the IPEX syndrome are located in this domain


Pssm-ID: 465036  Cd Length: 68  Bit Score: 143.21  E-value: 4.54e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 289666734  367 LYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHL 434
Cdd:pfam16159   1 LFGHGVCRWPGCETVCEDFGSFLKHLNSEHALDDRSTAQCRVQMQVVQQLEIQLTKEKERLQAMMAHL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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