NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|285026483|ref|NP_001165544|]
View 

tetratricopeptide repeat protein 4 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 175-334 1.58e-75

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


:

Pssm-ID: 439174  Cd Length: 153  Bit Score: 229.37  E-value: 1.58e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483 175 EALLQAIKARNIRLVSESAGEDEDSASNGPaeilldglSSENPYGARLSIDDQGRLSWPVLFLYPEYAQSDFISAFHEDT 254
Cdd:cd21380    1 EKLIKAIKERGIKLEGSKKGESDDLSLLEP--------CHPELSGARVHLDEEGRLVWPVLFLYPEYKQSDFIQAFHEDT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483 255 RFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDEDRAELYQVSPDSTLLQVLQHPRCCVKALTPAFLVCVGSSPFCRNYL 334
Cdd:cd21380   73 TFIDHLEVMFEEPPPWDVEKKYTPDNLNVYFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLVKGSEFEKEFL 152
3a0801s09 super family cl36792
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 28-173 1.50e-09

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00990:

Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 59.23  E-value: 1.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483   28 RYPEEQAKTY----KDEGNDYFKEKDYKKAVLSYSEGLKKKcADPdlnaVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKP 103
Cdd:TIGR00990 117 NLSEEERKKYaaklKEKGNKAYRNKDFNKAIKLYSKAIECK-PDP----VYYSNRAACHNALGDWEKVVEDTTAALELDP 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  104 GHLKAIIRGALCHLELKHFAEAvnwcdeglqidakekkLLEIRA-------KADKLKRMEERDLRK---AKLKEKKEQHQ 173
Cdd:TIGR00990 192 DYSKALNRRANAYDGLGKYADA----------------LLDLTAsciidgfRNEQSAQAVERLLKKfaeSKAKEILETKP 255
 
Name Accession Description Interval E-value
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 175-334 1.58e-75

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439174  Cd Length: 153  Bit Score: 229.37  E-value: 1.58e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483 175 EALLQAIKARNIRLVSESAGEDEDSASNGPaeilldglSSENPYGARLSIDDQGRLSWPVLFLYPEYAQSDFISAFHEDT 254
Cdd:cd21380    1 EKLIKAIKERGIKLEGSKKGESDDLSLLEP--------CHPELSGARVHLDEEGRLVWPVLFLYPEYKQSDFIQAFHEDT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483 255 RFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDEDRAELYQVSPDSTLLQVLQHPRCCVKALTPAFLVCVGSSPFCRNYL 334
Cdd:cd21380   73 TFIDHLEVMFEEPPPWDVEKKYTPDNLNVYFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLVKGSEFEKEFL 152
Wheel pfam18972
Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human ...
 225-309 1.90e-23

Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.


Pssm-ID: 436877  Cd Length: 114  Bit Score: 93.05  E-value: 1.90e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  225 DDQGRLSWPVLFLYPEYAQSDFISAFHEDTRFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDeDRAELYQVSPDSTLLQ 304
Cdd:pfam18972   4 DPESTLIFPVFFLYPLHAQSDFIKAFSETTTPQDHLEYVFPSPPPWDTKKEYTPKNVEVYMET-RTGGLVKVGKKVPLRK 82


                  ....*
gi 285026483  305 VLQHP 309
Cdd:pfam18972  83 VLSSA 87
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 28-173 1.50e-09

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 59.23  E-value: 1.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483   28 RYPEEQAKTY----KDEGNDYFKEKDYKKAVLSYSEGLKKKcADPdlnaVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKP 103
Cdd:TIGR00990 117 NLSEEERKKYaaklKEKGNKAYRNKDFNKAIKLYSKAIECK-PDP----VYYSNRAACHNALGDWEKVVEDTTAALELDP 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  104 GHLKAIIRGALCHLELKHFAEAvnwcdeglqidakekkLLEIRA-------KADKLKRMEERDLRK---AKLKEKKEQHQ 173
Cdd:TIGR00990 192 DYSKALNRRANAYDGLGKYADA----------------LLDLTAsciidgfRNEQSAQAVERLLKKfaeSKAKEILETKP 255
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
19-136 4.09e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.08  E-value: 4.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  19 LQSMIFDDDRYPEEQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAA 98
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE---LDPD-LAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 285026483  99 KKLKPGHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 136
Cdd:COG4785  134 LELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171
 
Name Accession Description Interval E-value
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 175-334 1.58e-75

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439174  Cd Length: 153  Bit Score: 229.37  E-value: 1.58e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483 175 EALLQAIKARNIRLVSESAGEDEDSASNGPaeilldglSSENPYGARLSIDDQGRLSWPVLFLYPEYAQSDFISAFHEDT 254
Cdd:cd21380    1 EKLIKAIKERGIKLEGSKKGESDDLSLLEP--------CHPELSGARVHLDEEGRLVWPVLFLYPEYKQSDFIQAFHEDT 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483 255 RFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDEDRAELYQVSPDSTLLQVLQHPRCCVKALTPAFLVCVGSSPFCRNYL 334
Cdd:cd21380   73 TFIDHLEVMFEEPPPWDVEKKYTPDNLNVYFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLVKGSEFEKEFL 152
CTWD_Cns1-like cd21377
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo ...
 175-335 8.36e-45

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo sapiens tetratricopeptide repeat protein 4 (TTC4), and similar proteins; The family includes Hsp70/Hsp90 co-chaperone Cns1 from Saccharomyces cerevisiae and the human Cns1 homolog tetratricopeptide repeat protein 4 (TTC4), both of which contain a C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses.


Pssm-ID: 439173  Cd Length: 159  Bit Score: 150.57  E-value: 8.36e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483 175 EALLQAIKARNIRLvsesagededsasnGPAEilldgLSSENPYGARLSIDDQGRLSWPVLFLYPEYAQSDFISAFHEDT 254
Cdd:cd21377    1 KALLSALKSRGIKL--------------GPPL-----YDEELTGERKPYLDEDGELHWPVLLLYPEVGQSDFIEDFSEDD 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483 255 RFIDHLMAMFSE---APSWDSEHKYHPENLEVYFED--------------EDRAELYQVSPDSTLLQVLQHPRCCVKALT 317
Cdd:cd21377   62 TLGDHLDVMFPEpapPLPWDTEGEYTRDNLEVYYETnavkplpsesskagPKEKKWVRVDPDTTLGDVLAHPDYYVIPGI 141

                        170
                 ....*....|....*...
gi 285026483 318 PAFLVCVGSSPFCRNYLQ 335
Cdd:cd21377  142 PVFYVVPKGSPFEKRFLK 159
Wheel pfam18972
Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human ...
 225-309 1.90e-23

Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.


Pssm-ID: 436877  Cd Length: 114  Bit Score: 93.05  E-value: 1.90e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  225 DDQGRLSWPVLFLYPEYAQSDFISAFHEDTRFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDeDRAELYQVSPDSTLLQ 304
Cdd:pfam18972   4 DPESTLIFPVFFLYPLHAQSDFIKAFSETTTPQDHLEYVFPSPPPWDTKKEYTPKNVEVYMET-RTGGLVKVGKKVPLRK 82


                  ....*
gi 285026483  305 VLQHP 309
Cdd:pfam18972  83 VLSSA 87
CTWD_TTC4 cd21381
C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and ...
 166-309 2.59e-22

C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and similar proteins; TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses. The model corresponds to TTC4 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439175  Cd Length: 150  Bit Score: 91.42  E-value: 2.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483 166 KEKKEQhqneALLQAIKARNIRLV-SESAGEDEDsasngPAEILLdglssENPygarLSIDDQgrLSWPVLFLYPEYAQS 244
Cdd:cd21381    1 KERKKK----TLKAALKARNITTRtTSQPPELLE-----DAKILL-----EDP----LDPESQ--LIFPALLLYPLHLQS 60

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 285026483 245 DFISAFHEDTRFIDHLMAMFSEAPSWDSEHKYHPENLEVYFEDEDrAELYQVSPDSTLLQVLQHP 309
Cdd:cd21381   61 DFIKAFSELSTPQEHLEYVLPRPWDWDKHEEYTPKNVECYMETES-GGLVKVGKKVPLLKVLSNG 124
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 28-173 1.50e-09

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 59.23  E-value: 1.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483   28 RYPEEQAKTY----KDEGNDYFKEKDYKKAVLSYSEGLKKKcADPdlnaVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKP 103
Cdd:TIGR00990 117 NLSEEERKKYaaklKEKGNKAYRNKDFNKAIKLYSKAIECK-PDP----VYYSNRAACHNALGDWEKVVEDTTAALELDP 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  104 GHLKAIIRGALCHLELKHFAEAvnwcdeglqidakekkLLEIRA-------KADKLKRMEERDLRK---AKLKEKKEQHQ 173
Cdd:TIGR00990 192 DYSKALNRRANAYDGLGKYADA----------------LLDLTAsciidgfRNEQSAQAVERLLKKfaeSKAKEILETKP 255
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
19-136 4.09e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.08  E-value: 4.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  19 LQSMIFDDDRYPEEQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAA 98
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE---LDPD-LAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 285026483  99 KKLKPGHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 136
Cdd:COG4785  134 LELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
32-163 3.12e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 3.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  32 EQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKKkcaDPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIR 111
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL---DPD-DAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 285026483 112 GALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEIRAKA-DKLKRMEE--RDLRKA 163
Cdd:COG0457   82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLAlLELGRYDEaiEAYERA 136
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
32-210 5.32e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.01  E-value: 5.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  32 EQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIR 111
Cdd:COG0457   40 DDAEALYNLGLAYLRLGRYEEALADYEQALE---LDPD-DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483 112 GALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEIRAKAdkLKRMEERDLRKAKLKEKKEQHQNEALLQAIKARNIRLVSE 191
Cdd:COG0457  116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA--LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAA 193

                        170
                 ....*....|....*....
gi 285026483 192 SAGEDEDSASNGPAEILLD 210
Cdd:COG0457  194 EVLLALLLALEQALRKKLA 212
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
32-206 1.44e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.77  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  32 EQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIR 111
Cdd:COG0457   74 DDAEALNNLGLALQALGRYEEALEDYDKALE---LDPD-DAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483 112 GALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEIRAKADKLKRMEERDLRKAKLKEKKEQHQNEALLQAIKARNIRLVSE 191
Cdd:COG0457  150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALAL 229

                        170
                 ....*....|....*
gi 285026483 192 SAGEDEDSASNGPAE 206
Cdd:COG0457  230 LLALRLAALALYQYR 244
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 41-147 2.74e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.37  E-value: 2.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  41 GNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIRGALCHLELK 120
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALR---LDPD-NADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQG 99

                         90       100
                 ....*....|....*....|....*..
gi 285026483 121 HFAEAVNWCDEGLQIDAKEKKLLEIRA 147
Cdd:COG4235  100 DYAEAIAAWQKLLALLPADAPARLLEA 126
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 25-136 5.50e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.90  E-value: 5.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  25 DDDRYPEEQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPG 104
Cdd:COG3914   69 AAAAALLLLAALLELAALLLQALGRYEEALALYRRALA---LNPD-NAEALFNLGNLLLALGRLEEALAALRRALALNPD 144

                         90       100       110
                 ....*....|....*....|....*....|..
gi 285026483 105 HLKAIIRGALCHLELKHFAEAVNWCDEGLQID 136
Cdd:COG3914  145 FAEAYLNLGEALRRLGRLEEAIAALRRALELD 176
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
32-120 9.01e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.28  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  32 EQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDLNAVLYtNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIR 111
Cdd:COG4785  105 DLAEAYNNRGLAYLLLGDYDAALEDFDRALE---LDPDYAYAYL-NRGIALYYLGRYELAIADLEKALELDPNDPERALW 180


                 ....*....
gi 285026483 112 GALCHLELK 120
Cdd:COG4785  181 LYLAERKLD 189
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 34-178 1.76e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.98  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  34 AKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDLnavlytnrAAAQYYLGNVRSSLNDVLAAK-------KLKPGHL 106
Cdd:COG3914  112 AEALFNLGNLLLALGRLEEALAALRRALA---LNPDF--------AEAYLNLGEALRRLGRLEEAIaalrralELDPDNA 180

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 285026483 107 KAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKK----LLEIRAKADKLKRMEERDLRKAKLKEKKEQHQNEALL 178
Cdd:COG3914  181 EALNNLGNALQDLGRLEEAIAAYRRALELDPDNADahsnLLFALRQACDWEVYDRFEELLAALARGPSELSPFALL 256
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
44-138 2.52e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  44 YFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLnDVLAAKKLKPGHLKAIIRGALCHLELKHFA 123
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALE---LDPD-NADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYD 76

                         90
                 ....*....|....*
gi 285026483 124 EAVNWCDEGLQIDAK 138
Cdd:COG3063   77 EALAYLERALELDPS 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 44-181 4.35e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.17  E-value: 4.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  44 YFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAIIRGALCHLELKHFA 123
Cdd:COG2956  120 YEQEGDWEKAIEVLERLLK---LGPE-NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYE 195

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 285026483 124 EAVNWCDEGLQIDAKEKKLLEIRAKAdkLKRMEERDLRKAKLKEKKEQHQNEALLQAI 181
Cdd:COG2956  196 EAIAALERALEQDPDYLPALPRLAEL--YEKLGDPEEALELLRKALELDPSDDLLLAL 251
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 31-157 7.39e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.79  E-value: 7.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  31 EEQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAII 110
Cdd:COG2956  141 PENAHAYCELAELYLEQGDYDEAIEALEKALK---LDPD-CARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALP 216

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 285026483 111 RGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEIRAKADKLKRMEE 157
Cdd:COG2956  217 RLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEA 263
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 31-175 9.64e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 35.94  E-value: 9.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285026483  31 EEQAKTYKDEGNDYFKEKDYKKAVLSYSEGLKkkcADPDlNAVLYTNRAAAQYYLGNVRSSLNDVLAAKKLKPGHLKAII 110
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALE---LDPD-NPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARL 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 285026483 111 RGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEIRAKAdkLKRMEERDLRKAKLKEKKEQHQNE 175
Cdd:COG4783   77 NLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA--YRALGRPDEAIAALEKALELDPDD 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH