NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|262263303|ref|NP_001160143|]
View 

gem-associated protein 5 isoform 4 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-448 2.05e-41

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.77  E-value: 2.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303   46 LLLWDLTQSWRRKYTLFSTSAEGHNHSRIvfnlcSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAF 125
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVL-----SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  126 SPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQISST 205
Cdd:COG2319   129 SP-DGKTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  206 yHKKTVYRLAWGPpvppmslGGEgdrpslTLYSCGGEGVVlqhnpwKLsgeaFDInklvrDTNSIRYKLPVHTE----IS 281
Cdd:COG2319   203 -HTGAVRSVAFSP-------DGK------LLASGSADGTV------RL----WDL-----ATGKLLRTLTGHSGsvrsVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  282 WKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHEhGSRpelsclLASGSNNAVIYVHNLKAvlesnpe 361
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKL------LASGSDDGTVRLWDLAT------- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  362 spitiTEPYRTLSGHTAKITSLAWSPhhDGR-LVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGA 440
Cdd:COG2319   320 -----GKLLRTLTGHTGAVRSVAFSP--DGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGS 391


                  ....*...
gi 262263303  441 DDFCVYRW 448
Cdd:COG2319   392 ADGTVRLW 399
COG3899 super family cl28481
Predicted ATPase [General function prediction only];
611-971 9.20e-03

Predicted ATPase [General function prediction only];


The actual alignment was detected with superfamily member COG3899:

Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 40.61  E-value: 9.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  611 HAKAELNEDVSADLEERFHLGLFTDRATLYRMMETEGKGHLESGHPELF--HQLMLWKGDLKGVLQAAAERGELTDSLVA 688
Cdd:COG3899   806 YEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLReaLEAGLETGDAALALLALAAAAAAAAAAAA 885

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  689 VAPVAGYSVWLWAVEAFAKQLCFQDQYVKAASYLLSIHKVYEAVEllksnhLYREAIAVAKARLRPEdpvlkELYLSWGS 768
Cdd:COG3899   886 LAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAA------LALAAAAAAAAAAALA-----AAAAAAAL 954

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  769 ILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTAAELAAIAGEHELAASLALRCAQELLLMKNWVGAQEALGLH 848
Cdd:COG3899   955 AAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAA 1034

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  849 ESLQGQRLVFCLLELLCRHLEEKQPLEVRGPSSIYHQWATGSEGTLVQRVTGVWRSAFSVDTPEQCQAALQKLQDVKYPS 928
Cdd:COG3899  1035 ALLAAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAAL 1114

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 262263303  929 ATSNTPFRQLLLHVCHDLTLAMLSQQAAAWEEAVPALLQAVVR 971
Cdd:COG3899  1115 ALAAALAALALAAAARAAAALLLLAAALALALAALLLLAALLL 1157
FimV COG3170
Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];
1043-1169 9.67e-03

Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];


:

Pssm-ID: 442403 [Multi-domain]  Cd Length: 508  Bit Score: 40.16  E-value: 9.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303 1043 AESTVSDKQSKPEDSASAEDMEQPPGPGPRLSAESERLLSAcKELFSERHASLQTSQRtVAEVQETLAEMIRQHQKSQLC 1122
Cdd:COG3170   241 VEPAPAAAAPAAPPAAAAAAGPVPAAAEDTLSPEVTAAAAA-EEADALPEAAAELAER-LAALEAQLAELQRLLALKNPA 318

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 262263303 1123 KATTNGP--SRDEPSRDEPSQEAERAPSQPPSPTEERNAPVSLPELTRR 1169
Cdd:COG3170   319 PAAAVSApaAAAAAATVEAAAPAAAAQPAAAAPAPALDNPLLLAGLLRR 367
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-448 2.05e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.77  E-value: 2.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303   46 LLLWDLTQSWRRKYTLFSTSAEGHNHSRIvfnlcSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAF 125
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVL-----SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  126 SPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQISST 205
Cdd:COG2319   129 SP-DGKTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  206 yHKKTVYRLAWGPpvppmslGGEgdrpslTLYSCGGEGVVlqhnpwKLsgeaFDInklvrDTNSIRYKLPVHTE----IS 281
Cdd:COG2319   203 -HTGAVRSVAFSP-------DGK------LLASGSADGTV------RL----WDL-----ATGKLLRTLTGHSGsvrsVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  282 WKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHEhGSRpelsclLASGSNNAVIYVHNLKAvlesnpe 361
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKL------LASGSDDGTVRLWDLAT------- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  362 spitiTEPYRTLSGHTAKITSLAWSPhhDGR-LVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGA 440
Cdd:COG2319   320 -----GKLLRTLTGHTGAVRSVAFSP--DGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGS 391


                  ....*...
gi 262263303  441 DDFCVYRW 448
Cdd:COG2319   392 ADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-406 6.88e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 6.88e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303   67 EGHNHSrivfnLCSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWN 146
Cdd:cd00200     6 KGHTGG-----VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  147 tlsIKNNYDVKNFwQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKpPQISSTYHKKTVYRLAWGPpvppmslg 226
Cdd:cd00200    80 ---LETGECVRTL-TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK-CLTTLRGHTDWVNSVAFSP-------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  227 gegdrPSLTLYSCGGEGVVlqhnpwKLsgeaFDINklvrdTNSIRYKLPVHTE----ISWKGDGKVLALGNEDGSIEIFQ 302
Cdd:cd00200   146 -----DGTFVASSSQDGTI------KL----WDLR-----TGKCVATLTGHTGevnsVAFSPDGEKLLSSSSDGTIKLWD 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  303 VPNLRLLCTIQQHHKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNLKAvlesnpespitiTEPYRTLSGHTAKITS 382
Cdd:cd00200   206 LSTGKCLGTLRGHENGVNSVAFSPDGY-------LLASGSEDGTIRVWDLRT------------GECVQTLSGHTNSVTS 266

                         330       340
                  ....*....|....*....|....*
gi 262263303  383 LAWSPhhDG-RLVSACYDGTAQVWD 406
Cdd:cd00200   267 LAWSP--DGkRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 368-406 1.64e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 1.64e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 262263303    368 EPYRTLSGHTAKITSLAWSPHHDgRLVSACYDGTAQVWD 406
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 337-448 4.22e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 4.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  337 LLASGSNNAVIYVHNLKAVLESNPEspitITEPYRTLSGHTaKITSLAWSPHHDGRLVSACYDGTAQVWDALREEPLFNF 416
Cdd:PLN00181  497 FFATAGVNKKIKIFECESIIKDGRD----IHYPVVELASRS-KLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEM 571

                          90       100       110
                  ....*....|....*....|....*....|..
gi 262263303  417 RGHRGRLLCVAWSPVDPECIYSGADDFCVYRW 448
Cdd:PLN00181  572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
WD40 pfam00400
WD domain, G-beta repeat;
368-406 1.42e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 1.42e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 262263303   368 EPYRTLSGHTAKITSLAWSPHHDgRLVSACYDGTAQVWD 406
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
COG3899 COG3899
Predicted ATPase [General function prediction only];
611-971 9.20e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 40.61  E-value: 9.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  611 HAKAELNEDVSADLEERFHLGLFTDRATLYRMMETEGKGHLESGHPELF--HQLMLWKGDLKGVLQAAAERGELTDSLVA 688
Cdd:COG3899   806 YEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLReaLEAGLETGDAALALLALAAAAAAAAAAAA 885

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  689 VAPVAGYSVWLWAVEAFAKQLCFQDQYVKAASYLLSIHKVYEAVEllksnhLYREAIAVAKARLRPEdpvlkELYLSWGS 768
Cdd:COG3899   886 LAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAA------LALAAAAAAAAAAALA-----AAAAAAAL 954

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  769 ILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTAAELAAIAGEHELAASLALRCAQELLLMKNWVGAQEALGLH 848
Cdd:COG3899   955 AAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAA 1034

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  849 ESLQGQRLVFCLLELLCRHLEEKQPLEVRGPSSIYHQWATGSEGTLVQRVTGVWRSAFSVDTPEQCQAALQKLQDVKYPS 928
Cdd:COG3899  1035 ALLAAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAAL 1114

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 262263303  929 ATSNTPFRQLLLHVCHDLTLAMLSQQAAAWEEAVPALLQAVVR 971
Cdd:COG3899  1115 ALAAALAALALAAAARAAAALLLLAAALALALAALLLLAALLL 1157
FimV COG3170
Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];
1043-1169 9.67e-03

Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];


Pssm-ID: 442403 [Multi-domain]  Cd Length: 508  Bit Score: 40.16  E-value: 9.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303 1043 AESTVSDKQSKPEDSASAEDMEQPPGPGPRLSAESERLLSAcKELFSERHASLQTSQRtVAEVQETLAEMIRQHQKSQLC 1122
Cdd:COG3170   241 VEPAPAAAAPAAPPAAAAAAGPVPAAAEDTLSPEVTAAAAA-EEADALPEAAAELAER-LAALEAQLAELQRLLALKNPA 318

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 262263303 1123 KATTNGP--SRDEPSRDEPSQEAERAPSQPPSPTEERNAPVSLPELTRR 1169
Cdd:COG3170   319 PAAAVSApaAAAAAATVEAAAPAAAAQPAAAAPAPALDNPLLLAGLLRR 367
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-448 2.05e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.77  E-value: 2.05e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303   46 LLLWDLTQSWRRKYTLFSTSAEGHNHSRIvfnlcSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAF 125
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVL-----SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  126 SPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQISST 205
Cdd:COG2319   129 SP-DGKTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  206 yHKKTVYRLAWGPpvppmslGGEgdrpslTLYSCGGEGVVlqhnpwKLsgeaFDInklvrDTNSIRYKLPVHTE----IS 281
Cdd:COG2319   203 -HTGAVRSVAFSP-------DGK------LLASGSADGTV------RL----WDL-----ATGKLLRTLTGHSGsvrsVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  282 WKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHEhGSRpelsclLASGSNNAVIYVHNLKAvlesnpe 361
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKL------LASGSDDGTVRLWDLAT------- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  362 spitiTEPYRTLSGHTAKITSLAWSPhhDGR-LVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGA 440
Cdd:COG2319   320 -----GKLLRTLTGHTGAVRSVAFSP--DGKtLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGS 391


                  ....*...
gi 262263303  441 DDFCVYRW 448
Cdd:COG2319   392 ADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
34-407 1.10e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 1.10e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303   34 PTQLVSSCFGGELLLWDLTQSWRRkytlfsTSAEGHNHS--RIVFnlcslkTEDGkQLLLSTSMDRDVKCWDMATLECCW 111
Cdd:COG2319    90 GRLLASASADGTVRLWDLATGLLL------RTLTGHTGAvrSVAF------SPDG-KTLASGSADGTVRLWDLATGKLLR 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  112 TLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPNkeGC-LAFGTDDGKVG 190
Cdd:COG2319   157 TLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRSVAFSPD--GKlLASGSADGTVR 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  191 LYDTcSNKPPQISSTYHKKTVYRLAWGPpvppmslGGEgdrpslTLYSCGGEGVVLQhnpWKLsgeafdinklvrDTNSI 270
Cdd:COG2319   230 LWDL-ATGKLLRTLTGHSGSVRSVAFSP-------DGR------LLASGSADGTVRL---WDL------------ATGEL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  271 RYKLPVHTE----ISWKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHeHGSRpelsclLASGSNNAV 346
Cdd:COG2319   281 LRTLTGHSGgvnsVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKT------LASGSDDGT 353

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 262263303  347 IYVHNLKAvlesnpespitiTEPYRTLSGHTAKITSLAWSPhhDGR-LVSACYDGTAQVWDA 407
Cdd:COG2319   354 VRLWDLAT------------GELLRTLTGHTGAVTSVAFSP--DGRtLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
88-448 4.16e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.14  E-value: 4.16e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303   88 QLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKV 167
Cdd:COG2319    49 ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGL----LLRTLTGHTGAV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  168 TALCWHPNKEgCLAFGTDDGKVGLYDTCSNKPPQISSTyHKKTVYRLAWGPpvppmslGGEgdrpslTLYSCGGEGVVLQ 247
Cdd:COG2319   124 RSVAFSPDGK-TLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSP-------DGK------LLASGSDDGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  248 hnpWKLsgeafdinklvrDTNSIRYKLPVHTE----ISWKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIV 323
Cdd:COG2319   189 ---WDL------------ATGKLLRTLTGHTGavrsVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  324 WHHEhGSRpelsclLASGSNNAVIYVHNLKAvlesnpespitiTEPYRTLSGHTAKITSLAWSPhhDGR-LVSACYDGTA 402
Cdd:COG2319   254 FSPD-GRL------LASGSADGTVRLWDLAT------------GELLRTLTGHSGGVNSVAFSP--DGKlLASGSDDGTV 312

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 262263303  403 QVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGADDFCVYRW 448
Cdd:COG2319   313 RLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-406 6.88e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 6.88e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303   67 EGHNHSrivfnLCSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWN 146
Cdd:cd00200     6 KGHTGG-----VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  147 tlsIKNNYDVKNFwQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDTCSNKpPQISSTYHKKTVYRLAWGPpvppmslg 226
Cdd:cd00200    80 ---LETGECVRTL-TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK-CLTTLRGHTDWVNSVAFSP-------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  227 gegdrPSLTLYSCGGEGVVlqhnpwKLsgeaFDINklvrdTNSIRYKLPVHTE----ISWKGDGKVLALGNEDGSIEIFQ 302
Cdd:cd00200   146 -----DGTFVASSSQDGTI------KL----WDLR-----TGKCVATLTGHTGevnsVAFSPDGEKLLSSSSDGTIKLWD 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  303 VPNLRLLCTIQQHHKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNLKAvlesnpespitiTEPYRTLSGHTAKITS 382
Cdd:cd00200   206 LSTGKCLGTLRGHENGVNSVAFSPDGY-------LLASGSEDGTIRVWDLRT------------GECVQTLSGHTNSVTS 266

                         330       340
                  ....*....|....*....|....*
gi 262263303  383 LAWSPhhDG-RLVSACYDGTAQVWD 406
Cdd:cd00200   267 LAWSP--DGkRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 160-448 8.36e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 8.36e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  160 WQGVKSKVTALCWHPNKEGcLAFGTDDGKVGLYDTCSNKpPQISSTYHKKTVYRLAWGPpvppmslggegdrPSLTLYSC 239
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASA-------------DGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  240 GGEGVVlqhnpwKLsgeaFDINklvrdTNSIRYKLPVHTE----ISWKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQH 315
Cdd:cd00200    70 SSDKTI------RL----WDLE-----TGECVRTLTGHTSyvssVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  316 HKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNLK-----AVLE-----------SNPESPI-------TIT----- 367
Cdd:cd00200   135 TDWVNSVAFSPDGT-------FVASSSQDGTIKLWDLRtgkcvATLTghtgevnsvafSPDGEKLlssssdgTIKlwdls 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  368 --EPYRTLSGHTAKITSLAWSPhhDGRLVSACY-DGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGADDFC 444
Cdd:cd00200   208 tgKCLGTLRGHENGVNSVAFSP--DGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGT 284


                  ....
gi 262263303  445 VYRW 448
Cdd:cd00200   285 IRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
12-305 1.55e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 1.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303   12 SGGVDPTVkeRLW--------LTLHWPKNQPT---------QLVSSCFGGELLLWDLTqSWRRKYTLfstsaEGHNHS-- 72
Cdd:COG2319   137 SGSADGTV--RLWdlatgkllRTLTGHSGAVTsvafspdgkLLASGSDDGTVRLWDLA-TGKLLRTL-----TGHTGAvr 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303   73 RIVFnlcslkTEDGkQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPvDVGSLAIGVGDGMIRVWNTlsikN 152
Cdd:COG2319   209 SVAF------SPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDL----A 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  153 NYDVKNFWQGVKSKVTALCWHPNkeGC-LAFGTDDGKVGLYDTCSNKPPQISSTyHKKTVYRLAWGPpvppmslGGEgdr 231
Cdd:COG2319   277 TGELLRTLTGHSGGVNSVAFSPD--GKlLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSP-------DGK--- 343

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 262263303  232 pslTLYSCGGEGVVlqhnpwKLsgeaFDInklvrDTNSIRYKLPVHTE----ISWKGDGKVLALGNEDGSIEIFQVPN 305
Cdd:COG2319   344 ---TLASGSDDGTV------RL----WDL-----ATGELLRTLTGHTGavtsVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 35-302 9.90e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 9.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303   35 TQLVSSCFGGELLLWDLtQSWRRKYTLfstsaEGHNHSrivfnLCSLKTEDGKQLLLSTSMDRDVKCWDMATLECCWTLP 114
Cdd:cd00200    64 TYLASGSSDKTIRLWDL-ETGECVRTL-----TGHTSY-----VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  115 SLGGFAYSLAFSPVDvGSLAIGVGDGMIRVWNtlsIKNNYDVKNFwQGVKSKVTALCWHPNKEgCLAFGTDDGKVGLYDT 194
Cdd:cd00200   133 GHTDWVNSVAFSPDG-TFVASSSQDGTIKLWD---LRTGKCVATL-TGHTGEVNSVAFSPDGE-KLLSSSSDGTIKLWDL 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  195 csNKPPQISS-TYHKKTVYRLAWGPpvppmslggegdrPSLTLYSCGGEGVVLQhnpWKLsgeafdinklvrDTNSIRYK 273
Cdd:cd00200   207 --STGKCLGTlRGHENGVNSVAFSP-------------DGYLLASGSEDGTIRV---WDL------------RTGECVQT 256

                         250       260       270
                  ....*....|....*....|....*....|...
gi 262263303  274 LPVHTE----ISWKGDGKVLALGNEDGSIEIFQ 302
Cdd:cd00200   257 LSGHTNsvtsLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 207-455 1.24e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 1.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  207 HKKTVYRLAWGPPVPpmslggegdrpslTLYSCGGEGVVLQhnpWKLsgeafdinklvrDTNSIRYKLPVHTE----ISW 282
Cdd:cd00200     8 HTGGVTCVAFSPDGK-------------LLATGSGDGTIKV---WDL------------ETGELLRTLKGHTGpvrdVAA 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  283 KGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNlkavlesnpes 362
Cdd:cd00200    60 SADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR-------ILSSSSRDKTIKVWD----------- 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  363 pITITEPYRTLSGHTAKITSLAWSPHhDGRLVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGADD 442
Cdd:cd00200   122 -VETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSD 198

                         250
                  ....*....|...
gi 262263303  443 FCVYRWLTSMQDH 455
Cdd:cd00200   199 GTIKLWDLSTGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
285-448 4.83e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.80  E-value: 4.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  285 DGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVWHHEHGsrpelscLLASGSNNAVIYVHNLKAvlesnpespi 364
Cdd:COG2319    47 DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR-------LLASASADGTVRLWDLAT---------- 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  365 tiTEPYRTLSGHTAKITSLAWSPhhDG-RLVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPvDPECIYSGADDF 443
Cdd:COG2319   110 --GLLLRTLTGHTGAVRSVAFSP--DGkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDG 184


                  ....*
gi 262263303  444 CVYRW 448
Cdd:COG2319   185 TVRLW 189
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 369-448 2.73e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.06  E-value: 2.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  369 PYRTLSGHTAKITSLAWSPHHDgRLVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWSPVDpECIYSGADDFCVYRW 448
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLW 78
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 368-406 1.64e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 1.64e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 262263303    368 EPYRTLSGHTAKITSLAWSPHHDgRLVSACYDGTAQVWD 406
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 337-448 4.22e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 4.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  337 LLASGSNNAVIYVHNLKAVLESNPEspitITEPYRTLSGHTaKITSLAWSPHHDGRLVSACYDGTAQVWDALREEPLFNF 416
Cdd:PLN00181  497 FFATAGVNKKIKIFECESIIKDGRD----IHYPVVELASRS-KLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEM 571

                          90       100       110
                  ....*....|....*....|....*....|..
gi 262263303  417 RGHRGRLLCVAWSPVDPECIYSGADDFCVYRW 448
Cdd:PLN00181  572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
WD40 pfam00400
WD domain, G-beta repeat;
368-406 1.42e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 1.42e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 262263303   368 EPYRTLSGHTAKITSLAWSPHHDgRLVSACYDGTAQVWD 406
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 278-324 3.84e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 46.50  E-value: 3.84e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 262263303   278 TEISWKGDGKVLALGNEDGSIEIFQVPNLRLLCTIQQHHKLVNAIVW 324
Cdd:pfam12894   42 TSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGW 88
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 87-211 9.82e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 9.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303   87 KQLLLSTSMDRDVKCWDMATLECCWTLPSLGGFAYSLAFSPVDVGSLAIGVGDGMIRVWntlSIKNNYDVKNfwqgVKSK 166
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW---SINQGVSIGT----IKTK 617

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 262263303  167 VTALCWH-PNKEG-CLAFGTDDGKVGLYDTCSNKPPQISSTYHKKTV 211
Cdd:PLN00181  618 ANICCVQfPSESGrSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTV 664
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 373-429 1.47e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 1.47e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 262263303   373 LSGHTAKITSLAWSPhhDGR-LVSACYDGTAQVWDALREEPLFNFRGHRGRLLCVAWS 429
Cdd:pfam12894   34 PDKEDLEVTSLAWRP--DGKlLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
PTZ00420 PTZ00420
coronin; Provisional
 332-414 7.68e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 7.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  332 PELSCLLASGSNNAVIYVHNLKavleSNPESPITITEPYRTLSGHTAKITSLAWSPHHDGRLVSACYDGTAQVWDALREE 411
Cdd:PTZ00420   84 PCFSEILASGSEDLTIRVWEIP----HNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159


                  ...
gi 262263303  412 PLF 414
Cdd:PTZ00420  160 RAF 162
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 411-448 7.82e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 7.82e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 262263303    411 EPLFNFRGHRGRLLCVAWSPvDPECIYSGADDFCVYRW 448
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 133-217 1.77e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 1.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303   133 LAIGVGDGMI--------RVWnTLSIKNNydvknfwqgvKSKVTALCWHPNkEGCLAFGTDDGKVGLYDTcSNKPPQISS 204
Cdd:pfam12894   10 IALATEDGELllhrlnwqRVW-TLSPDKE----------DLEVTSLAWRPD-GKLLAVGYSDGTVRLLDA-ENGKIVHHF 76

                           90
                   ....*....|...
gi 262263303   205 TYHKKTVYRLAWG 217
Cdd:pfam12894   77 SAGSDLITCLGWG 89
WD40 pfam00400
WD domain, G-beta repeat;
411-448 4.10e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 4.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 262263303   411 EPLFNFRGHRGRLLCVAWSPvDPECIYSGADDFCVYRW 448
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
COG3899 COG3899
Predicted ATPase [General function prediction only];
611-971 9.20e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 40.61  E-value: 9.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  611 HAKAELNEDVSADLEERFHLGLFTDRATLYRMMETEGKGHLESGHPELF--HQLMLWKGDLKGVLQAAAERGELTDSLVA 688
Cdd:COG3899   806 YEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLReaLEAGLETGDAALALLALAAAAAAAAAAAA 885

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  689 VAPVAGYSVWLWAVEAFAKQLCFQDQYVKAASYLLSIHKVYEAVEllksnhLYREAIAVAKARLRPEdpvlkELYLSWGS 768
Cdd:COG3899   886 LAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAA------LALAAAAAAAAAAALA-----AAAAAAAL 954

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  769 ILERDGHYAIAAKCYLGATSAYDAAKVLARKGDAASLRTAAELAAIAGEHELAASLALRCAQELLLMKNWVGAQEALGLH 848
Cdd:COG3899   955 AAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAA 1034

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303  849 ESLQGQRLVFCLLELLCRHLEEKQPLEVRGPSSIYHQWATGSEGTLVQRVTGVWRSAFSVDTPEQCQAALQKLQDVKYPS 928
Cdd:COG3899  1035 ALLAAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAAL 1114

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 262263303  929 ATSNTPFRQLLLHVCHDLTLAMLSQQAAAWEEAVPALLQAVVR 971
Cdd:COG3899  1115 ALAAALAALALAAAARAAAALLLLAAALALALAALLLLAALLL 1157
FimV COG3170
Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];
1043-1169 9.67e-03

Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];


Pssm-ID: 442403 [Multi-domain]  Cd Length: 508  Bit Score: 40.16  E-value: 9.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262263303 1043 AESTVSDKQSKPEDSASAEDMEQPPGPGPRLSAESERLLSAcKELFSERHASLQTSQRtVAEVQETLAEMIRQHQKSQLC 1122
Cdd:COG3170   241 VEPAPAAAAPAAPPAAAAAAGPVPAAAEDTLSPEVTAAAAA-EEADALPEAAAELAER-LAALEAQLAELQRLLALKNPA 318

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 262263303 1123 KATTNGP--SRDEPSRDEPSQEAERAPSQPPSPTEERNAPVSLPELTRR 1169
Cdd:COG3170   319 PAAAVSApaAAAAAATVEAAAPAAAAQPAAAAPAPALDNPLLLAGLLRR 367
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH