NCBI Conserved Domain Search

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

615-872

1.30e-44

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 162.25 E-value: 1.30e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 615 WYPLASLPFyDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRcRHNS--LVYDGKIYTLGGLG 692
Cdd:COG3055    3 WSSLPDLPT-PRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPP-RHHAaaVAQDGKLYVFGGFT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 693 VAGN----VDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVlQSYVPQTNTWSFIES-PMID 767
Cdd:COG3055   81 GANPsstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWV-EVYDPATGTWTQLAPlPTPR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 768 NKYAPAVTLNGFVFILGGAYarattiYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGivssEGPALGNMEAYEPTT 847
Cdd:COG3055  160 DHLAAAVLPDGKILVIGGRN------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG----ESGFSDEVEAYDPAT 229

                        250       260
                 ....*....|....*....|....*
gi 256818756 848 NTWTLLPHMPCPVFRHGCVVIKKYI 872
Cdd:COG3055  230 NTWTALGELPTPRHGHAAVLTDGKV 254

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

436-537

2.97e-39

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 140.76 E-value: 2.97e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  436 CLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRAQY 515
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 256818756  516 AAELLAAVRLPFIHPSYLLNVV 537
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

436-536

2.22e-32

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 120.91 E-value: 2.22e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   436 CLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRAQY 515
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 256818756   516 AAELLAAVRLPFIHPSYLLNV 536
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

319-431

6.65e-25

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 100.02 E-value: 6.65e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLEFVYTGSLv 398
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVS-----EITLDDVSPEDFEALLEFMYTGKL- 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 256818756  399 IDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:pfam00651  75 ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

330-431

7.91e-21

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 87.75 E-value: 7.91e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   330 DLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLE 409
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKS-----EIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLE 75

                           90       100
                   ....*....|....*....|..
gi 256818756   410 AASKFQFHTFCKVCVSFLEKQL 431
Cdd:smart00225  76 LADYLQIPGLVELCEEFLLKLL 97

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

672-717

1.70e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 53.77 E-value: 1.70e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 256818756  672 PRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLP 717
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

PHA03247

large tegument protein UL36; Provisional

39-290

3.98e-09

large tegument protein UL36; Provisional

Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 60.72 E-value: 3.98e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   39 AGGSTASSLSARPGLLPLPVVPSRlPTPATAPApctTGSSEAITSLVVSSASAATTKAPgiSKADNQSQGLTTSIRWGQT 118
Cdd:PHA03247 2745 PAGPATPGGPARPARPPTTAGPPA-PAPPAAPA---AGPPRRLTRPAVASLSESRESLP--SPWDPADPPAAVLAPAAAL 2818

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  119 PVNQsTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQ--PSLITHSYGVTQPPTFSPAVNVQAPVIGVT---PSLPPHV 193
Cdd:PHA03247 2819 PPAA-SPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSvaPGGDVRRRPPSRSPAAKPAAPARPPVRRLArpaVSRSTES 2897

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  194 GPQLPLIPGHYSLPQPPSQPLSSVVVNMPAQALYASPQ------PLAVSTLP-GVGQVSRPGPTPvGNGHMAGPLLPPPP 266
Cdd:PHA03247 2898 FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPpprpqpPLAPTTDPaGAGEPSGAVPQP-WLGALVPGRVAVPR 2976

                         250       260
                  ....*....|....*....|....
gi 256818756  267 PAQPSAALPSSVPATNGPPTTDSA 290
Cdd:PHA03247 2977 FRVPQPAPSREAPASSTPPLTGHS 3000

Kelch

Kelch domain;

822-870

6.30e-08

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 49.48 E-value: 6.30e-08

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 256818756   822 KIYATGGIVSSEgpALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIKK 870
Cdd:smart00612   1 KIYVVGGFDGGQ--RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

Atrophin-1

pfam03154

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...

94-287

1.04e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.

Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 46.30 E-value: 1.04e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   94 TKAPGI-SKADNQSQGLTTS---IRWGQTPVNQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPSLITHSYGVTQP 169
Cdd:pfam03154 143 STSPSIpSPQDNESDSDSSAqqqILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQ 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  170 PTFSPAVNVQA--------------PVIGVTPSLPP-HVGPQLPLIPGHYSLPQPPSQPLSSVVVNMPAQAlyaSPQPLA 234
Cdd:pfam03154 223 STAAPHTLIQQtptlhpqrlpsphpPLQPMTQPPPPsQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPV---PPQPFP 299

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256818756  235 VSTLPGVGQVSrPGPTPVGNGHMAGPLLPPPPPAQPSAALPS----------SVPATNGPPTT 287
Cdd:pfam03154 300 LTPQSSQSQVP-PGPSPAAPGQSQQRIHTPPSQSQLQSQQPPreqplppaplSMPHIKPPPTT 361

Chi1

COG3469

Chitinase [Carbohydrate transport and metabolism];

21-193

1.05e-03

Chitinase [Carbohydrate transport and metabolism];

Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 42.43 E-value: 1.05e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  21 WSVNGTHGATSVCSVTSGAGGSTASSLSARPGLLPLPVVPSRLPTPATAPAPCTTGSSEAITSLVVSSASAATTKAPGIS 100
Cdd:COG3469   52 AASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 101 KADNQSQGLTTSIRWGQTPVNQSTPWDTDEPPSKQmrESDNPGTGPWVTTVAAGNQPSliTHSYGVTQPPTFSPAvnvqA 180
Cdd:COG3469  132 STTTSGASATSSAGSTTTTTTVSGTETATGGTTTT--STTTTTTSASTTPSATTTATA--TTASGATTPSATTTA----T 203

                        170
                 ....*....|...
gi 256818756 181 PVIGVTPSLPPHV 193
Cdd:COG3469  204 TTGPPTPGLPKHV 216

Name

Accession

Description

Interval

E-value

BTB_POZ_KLHL29_KBTBD9

cd18258

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

312-438

7.46e-83

Pssm-ID: 349567 [Multi-domain] Cd Length: 125 Bit Score: 261.45 E-value: 7.46e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 312 PKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSqsSREKLELVLSNLQADVLELLLEF 391
Cdd:cd18258    1 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSG--GGEKLELTMSNINADVLELLLEF 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 256818756 392 VYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18258   79 VYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125

BACK_KLHL29_KBTBD9

cd18468

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...

432-533

4.45e-62

Pssm-ID: 350543 [Multi-domain] Cd Length: 102 Bit Score: 204.57 E-value: 4.45e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 432 TASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPAT 511
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                         90       100
                 ....*....|....*....|..
gi 256818756 512 RAQYAAELLAAVRLPFIHPSYL 533
Cdd:cd18468   81 RKQHIAELLAVVRLPFIHPSYL 102

PHA03098

kelch-like protein; Provisional

333-860

2.13e-46

kelch-like protein; Provisional

Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 174.57 E-value: 2.13e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 333 IVVEGREFEVHQNVLASCSLYFKDLIqrsvqdSSQSSREKLELvlsNLQADVLELLLEFVYTGSLVIDSANAKTLLEAAS 412
Cdd:PHA03098  16 IVNGGGIIKVHKIILSSSSEYFKKMF------KNNFKENEINL---NIDYDSFNEVIKYIYTGKINITSNNVKDILSIAN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 413 KFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTK 492
Cdd:PHA03098  87 YLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 493 AEELVYETVIKWIKKDPATRAQYAAELLaavrlPFIHPSYLlnvvdNEELIKSSEACRdLVNEAKRYhmlPHARQEMQTP 572
Cdd:PHA03098 167 SEDVVLEIIIKWLTSKKNNKYKDICLIL-----KVLRITFL-----SEEGIKKLKRWK-LRIKKKKI---VFNKRCIKII 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 573 RTRPRLSAGVAEVIVLVGG-RQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFydREFFSVVSAGDNIYLSGGM-ESGVTL 650
Cdd:PHA03098 233 YSKKYNLNKILPRSSTFGSiIYIHITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNNVIYFIGGMnKNNLSV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 651 ADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGG 730
Cdd:PHA03098 311 NSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG-----AYARATTI--YDPEKGNIKA 803
Cdd:PHA03098 391 LIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidNIKVYNIVesYNPVTNKWTE 470

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 256818756 804 GPNMNHSRQFCSAVVLDGKIYATGGIvsSEGPALGNMEAYEPTTNTWTLLpHMPCPV 860
Cdd:PHA03098 471 LSSLNFPRINASLCIFNNKIYVVGGD--KYEYYINEIEVYDDKTNTWTLF-CKFPKV 524

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

615-872

1.30e-44

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 162.25 E-value: 1.30e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 615 WYPLASLPFyDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRcRHNS--LVYDGKIYTLGGLG 692
Cdd:COG3055    3 WSSLPDLPT-PRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPP-RHHAaaVAQDGKLYVFGGFT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 693 VAGN----VDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVlQSYVPQTNTWSFIES-PMID 767
Cdd:COG3055   81 GANPsstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWV-EVYDPATGTWTQLAPlPTPR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 768 NKYAPAVTLNGFVFILGGAYarattiYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGivssEGPALGNMEAYEPTT 847
Cdd:COG3055  160 DHLAAAVLPDGKILVIGGRN------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG----ESGFSDEVEAYDPAT 229

                        250       260
                 ....*....|....*....|....*
gi 256818756 848 NTWTLLPHMPCPVFRHGCVVIKKYI 872
Cdd:COG3055  230 NTWTALGELPTPRHGHAAVLTDGKV 254

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

562-831

8.28e-44

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 159.94 E-value: 8.28e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 562 LPHARQEMQTprtrprlsAGVAEVIVLVGGRQMVGMTQRSLVavtcWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLS 641
Cdd:COG3055    9 LPTPRSEAAA--------ALLDGKVYVAGGLSGGSASNSFEV----YDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 642 GGM----ESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLP 717
Cdd:COG3055   77 GGFtganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 718 KAV-HSAAATVCGGKIYVFGGVNEAGraagvlqsyvpQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTI--Y 794
Cdd:COG3055  157 TPRdHLAAAVLPDGKILVIGGRNGSG-----------FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVeaY 225

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 256818756 795 DPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVS 831
Cdd:COG3055  226 DPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETK 262

BACK_KLHL12

cd18452

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...

431-566

3.89e-40

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.

Pssm-ID: 350527 [Multi-domain] Cd Length: 136 Bit Score: 144.46 E-value: 3.89e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 256818756 511 TRAQYAAELLAAVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHAR 566
Cdd:cd18452   81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRPELR 136

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

436-537

2.97e-39

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 140.76 E-value: 2.97e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  436 CLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRAQY 515
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 256818756  516 AAELLAAVRLPFIHPSYLLNVV 537
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102

BACK_KLHL3

cd18513

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...

431-560

1.98e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.

Pssm-ID: 350588 [Multi-domain] Cd Length: 130 Bit Score: 125.18 E-value: 1.98e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 256818756 511 TRAQYAAELLAAVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYH 560
Cdd:cd18513   81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

436-536

2.22e-32

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 120.91 E-value: 2.22e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   436 CLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRAQY 515
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 256818756   516 AAELLAAVRLPFIHPSYLLNV 536
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101

BACK_KLHL2_like

cd18445

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...

434-544

1.38e-31

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

Pssm-ID: 350520 [Multi-domain] Cd Length: 114 Bit Score: 119.26 E-value: 1.38e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 434 SNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRA 513
Cdd:cd18445    4 SNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRK 83

                         90       100       110
                 ....*....|....*....|....*....|.
gi 256818756 514 QYAAELLAAVRLPFIHPSYLLNVVDNEELIK 544
Cdd:cd18445   84 EHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114

BACK_KLHL2_Mayven

cd18512

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...

431-560

8.34e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.

Pssm-ID: 350587 [Multi-domain] Cd Length: 130 Bit Score: 114.74 E-value: 8.34e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 256818756 511 TRAQYAAELLAAVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYH 560
Cdd:cd18512   81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130

BTB_POZ_KLHL21

cd18250

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

308-436

2.92e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349559 [Multi-domain] Cd Length: 124 Bit Score: 112.94 E-value: 2.92e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 308 DPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLEL 387
Cdd:cd18250    1 DPAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRAD-----RVVLHGVSAEILGL 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 256818756 388 LLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18250   76 LLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BACK_KLHL18

cd18457

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...

435-537

2.19e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.

Pssm-ID: 350532 [Multi-domain] Cd Length: 107 Bit Score: 107.01 E-value: 2.19e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 435 NCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRAQ 514
Cdd:cd18457    5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREE 84

                         90       100
                 ....*....|....*....|...
gi 256818756 515 YAAELLAAVRLPFIHPSYLLNVV 537
Cdd:cd18457   85 YLPELLSKVRLPLLRPQFLTDRV 107

BTB_POZ_KLHL35

cd18265

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-438

6.00e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349574 [Multi-domain] Cd Length: 128 Bit Score: 106.39 E-value: 6.00e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREklelvLSNLQADVLELL 388
Cdd:cd18265    4 PCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVE-----IQKVSAAAMEVL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18265   79 LDYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128

BTB_POZ_KLHL30

cd18259

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

295-438

1.07e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349568 [Multi-domain] Cd Length: 137 Bit Score: 106.07 E-value: 1.07e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 295 MLRTIGvgKYEFTDPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREkle 374
Cdd:cd18259    1 MVRNID--DLDFCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVE--- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256818756 375 lvLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18259   76 --IKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137

BTB_POZ_KLHL7

cd18237

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-438

2.08e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349546 [Multi-domain] Cd Length: 126 Bit Score: 104.88 E-value: 2.08e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREklelvLSNLQADVLELLLE 390
Cdd:cd18237    4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVE-----LKDAEPDIIELLVE 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18237   79 FAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126

BTB_POZ_KLHL25

cd18254

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-438

4.69e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349563 [Multi-domain] Cd Length: 128 Bit Score: 103.94 E-value: 4.69e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREklelVLSNLQADVLELL 388
Cdd:cd18254    3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVN----FHDSLHPEVLELL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18254   79 LDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128

BTB_POZ_KLHL24_KRIP6

cd18253

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-436

1.06e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349562 [Multi-domain] Cd Length: 121 Bit Score: 102.61 E-value: 1.06e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqDSSQSSREKLeLVLSNLQADVLELLLE 390
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFC----NDHRESREML-VEINGILAEAMDCFLQ 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18253   76 YVYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121

BTB_POZ_KLHL12_C3IP1_DKIR

cd18242

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

310-436

1.27e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349551 [Multi-domain] Cd Length: 124 Bit Score: 102.52 E-value: 1.27e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 310 GHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdSSQSSREKLELVLSNLQADVLELLL 389
Cdd:cd18242    3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFT-----SEMSEKGKSEVELQGLTASTMEILL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 256818756 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18242   78 DFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124

BTB_POZ_KLHL27_IPP

cd18256

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-438

5.06e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349565 [Multi-domain] Cd Length: 125 Bit Score: 100.94 E-value: 5.06e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLE 390
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKD-----VVQIHGVEPDIFHILLD 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18256   78 FIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

319-431

6.65e-25

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 100.02 E-value: 6.65e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLEFVYTGSLv 398
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVS-----EITLDDVSPEDFEALLEFMYTGKL- 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 256818756  399 IDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:pfam00651  75 ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB_POZ_KLHL10

cd18240

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

319-436

7.87e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349549 [Multi-domain] Cd Length: 120 Bit Score: 100.09 E-value: 7.87e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqDSSQSSREKLELVLSNLQADVLELLLEFVYTGSLV 398
Cdd:cd18240    8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALF-----TNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVP 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 256818756 399 IDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18240   83 ITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120

BACK_KLHL38

cd18476

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...

431-530

1.03e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.

Pssm-ID: 350551 [Multi-domain] Cd Length: 99 Bit Score: 99.05 E-value: 1.03e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLnTKAEELVYETVIKWIKKDPA 510
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                         90       100
                 ....*....|....*....|
gi 256818756 511 TRAQYAAELLAAVRLPFIHP 530
Cdd:cd18476   80 ARKGYIHDLFKKVRLQYVHP 99

BTB_POZ_KLHL38

cd18268

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

306-439

2.38e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349577 [Multi-domain] Cd Length: 129 Bit Score: 99.09 E-value: 2.38e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 306 FTDPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVL 385
Cdd:cd18268    1 FKDQDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQA-----KVDLKGIDSDVL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 256818756 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18268   76 DQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129

BACK_KLHL8

cd18448

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...

430-526

5.03e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Pssm-ID: 350523 [Multi-domain] Cd Length: 97 Bit Score: 96.99 E-value: 5.03e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18448    1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*..
gi 256818756 510 ATRAQYAAELLAAVRLP 526
Cdd:cd18448   81 QHRKRHLDDLLSQVRLP 97

BTB_POZ_ZBTB_KLHL-like

cd18186

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

328-414

6.23e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349497 [Multi-domain] Cd Length: 82 Bit Score: 96.08 E-value: 6.23e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSS-----EIELDDVSPEAFEALLDYIYTGELELSEENVEEL 75


                 ....*..
gi 256818756 408 LEAASKF 414
Cdd:cd18186   76 LAAADKL 82

BTB_POZ_KLHL37_ENC1

cd18267

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

304-439

1.44e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349576 [Multi-domain] Cd Length: 147 Bit Score: 97.37 E-value: 1.44e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 304 YEFTDPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSsQSSREKLElvlSNLQAD 383
Cdd:cd18267   16 YLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKES-QDSEVNFH---DSIHPE 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 256818756 384 VLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18267   92 VLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

571-745

2.01e-23

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 101.00 E-value: 2.01e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 571 TPRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVavtcWNPQNNKWYPLASLPFyDREFFSVVSAGDN-IYLSGGMES 646
Cdd:COG3055  106 APMPTPRGGATALLLdgkIYVVGGWDDGGNVAWVEV----YDPATGTWTQLAPLPT-PRDHLAAAVLPDGkILVIGGRNG 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 647 GVTLadvwcymsllDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGvaGNVDHVERYDTITNQWEAVAPLPKAVHSAAAT 726
Cdd:COG3055  181 SGFS----------NTWTTLAPLPTARAGHAAAVLGGKILVFGGES--GFSDEVEAYDPATNTWTALGELPTPRHGHAAV 248

                        170
                 ....*....|....*....
gi 256818756 727 VCGGKIYVFGGVNEAGRAA 745
Cdd:COG3055  249 LTDGKVYVIGGETKPGVRT 267

BTB_POZ_KLHL20_KLEIP

cd18249

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

306-438

3.08e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349558 [Multi-domain] Cd Length: 128 Bit Score: 95.98 E-value: 3.08e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 306 FTDPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVL 385
Cdd:cd18249    1 YTSDKHPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQT-----EVTIRDIDERAM 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 256818756 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18249   76 ELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128

BTB_POZ_NS1BP

cd18306

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-439

4.20e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349615 [Multi-domain] Cd Length: 124 Bit Score: 95.40 E-value: 4.20e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREklelvLSNLQADVLELLLE 390
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVK-----LDGLDPDAVEVLVN 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18306   76 YAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124

BACK_KLHL1_like

cd18444

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...

430-533

5.73e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.

Pssm-ID: 350519 [Multi-domain] Cd Length: 106 Bit Score: 94.32 E-value: 5.73e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18444    1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                         90       100
                 ....*....|....*....|....
gi 256818756 510 ATRAQYAAELLAAVRLPFIHPSYL 533
Cdd:cd18444   81 PERKKHLAKLLALIRLPLLTPQFL 104

BACK_KLHL19_KEAP1

cd18458

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...

430-520

2.61e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.

Pssm-ID: 350533 [Multi-domain] Cd Length: 91 Bit Score: 88.89 E-value: 2.61e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18458    1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                         90
                 ....*....|.
gi 256818756 510 ATRAQYAAELL 520
Cdd:cd18458   81 ENRRQYLEALL 91

BTB_POZ_KBTBD6_7

cd18273

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

305-440

6.13e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349582 [Multi-domain] Cd Length: 142 Bit Score: 89.88 E-value: 6.13e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 305 EFTDPGHPKEMLKELNQQRRAKAFTDLKIVVE--------GREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSrekleLV 376
Cdd:cd18273    3 ELEDAAHARALLAQLKSFYDARLLTDVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSMFTGGLYESKQET-----VT 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256818756 377 LSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVL 440
Cdd:cd18273   78 IHDVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141

BTB_POZ_ZBTB8A_BOZF1

cd18329

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-427

7.40e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349638 [Multi-domain] Cd Length: 116 Bit Score: 88.73 E-value: 7.40e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREKLELvlsnLQADVLELLLE 390
Cdd:cd18329    4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDV----FSPDTFTIILD 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18329   80 FVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

330-431

7.91e-21

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 87.75 E-value: 7.91e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   330 DLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLE 409
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKS-----EIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLE 75

                           90       100
                   ....*....|....*....|..
gi 256818756   410 AASKFQFHTFCKVCVSFLEKQL 431
Cdd:smart00225  76 LADYLQIPGLVELCEEFLLKLL 97

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-427

8.89e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 88.25 E-value: 8.89e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREKLELVlsnlQADVLELLLE 390
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVF----SSDAFSIILD 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18199   77 FVYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BTB_POZ_KLHL40-like

cd18269

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

313-439

1.83e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349578 [Multi-domain] Cd Length: 133 Bit Score: 88.23 E-value: 1.83e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 313 KEMLKElnqqrraKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdSSQSSREKLELVLSNLQADVLELLLEFV 392
Cdd:cd18269   19 KDLLDE-------NKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFL-----SDLEESKKKEVVLEDVDPDVMGMILKYL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 256818756 393 YTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18269   87 YTSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133

BACK_KEL_like

cd18508

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...

432-508

2.05e-20

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.

Pssm-ID: 350583 [Multi-domain] Cd Length: 77 Bit Score: 85.92 E-value: 2.05e-20

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 256818756 432 TASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKD 508
Cdd:cd18508    1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77

BTB_POZ_KLHL40_KBTBD5

cd18340

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

328-439

3.01e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349649 [Multi-domain] Cd Length: 134 Bit Score: 87.58 E-value: 3.01e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSsqssrEKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18340   27 FVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEES-----KKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDI 101

                         90       100       110
                 ....*....|....*....|....*....|..
gi 256818756 408 LEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18340  102 FAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133

BTB_POZ_KLHL8

cd18238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

314-438

6.26e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349547 [Multi-domain] Cd Length: 120 Bit Score: 86.19 E-value: 6.26e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 314 EMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREklelvLSNLQADVLELLLEFVY 393
Cdd:cd18238    1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSIT-----IKDIDEEAVELLVDFAY 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 256818756 394 TGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18238   76 TGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120

BTB_POZ_KLHL28_BTBD5

cd18257

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-433

7.41e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349566 [Multi-domain] Cd Length: 118 Bit Score: 86.05 E-value: 7.41e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVqdssqSSREKLELVLSNLQADVLELLLE 390
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNL-----SEKENSEVEFQCIDETALQAIVE 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTA 433
Cdd:cd18257   76 YAYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118

BACK_KLHL24

cd18463

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...

430-507

7.48e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.

Pssm-ID: 350538 [Multi-domain] Cd Length: 78 Bit Score: 84.37 E-value: 7.48e-20

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 256818756 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKK 507
Cdd:cd18463    1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78

BTB_POZ_KLHL23

cd18252

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

308-438

1.24e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349561 [Multi-domain] Cd Length: 127 Bit Score: 85.65 E-value: 1.24e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 308 DPGHPKEMLKELNQQRRAKAFTDLKIV-VEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLE 386
Cdd:cd18252    1 DSSHPADFLDAFRTFYLDGLFTDITLQcASGQIFHCHKAALAACSSYFKVMFTADMKEKSNN-----VIKLSGIDHDILE 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 256818756 387 LLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18252   76 ALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127

BTB_POZ_ZBTB7

cd18198

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-428

1.28e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349507 [Multi-domain] Cd Length: 120 Bit Score: 85.30 E-value: 1.28e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREklelvLSNLQADVLELL 388
Cdd:cd18198    6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYE-----IDFVSPEALTAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18198   81 LEFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120

BACK_KLHL10

cd18450

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...

431-509

1.31e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

Pssm-ID: 350525 [Multi-domain] Cd Length: 80 Bit Score: 83.81 E-value: 1.31e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQ-EEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHDP 80

BACK_KLHL37_ENC1

cd18515

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...

434-528

3.77e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350590 [Multi-domain] Cd Length: 98 Bit Score: 83.10 E-value: 3.77e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 434 SNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRA 513
Cdd:cd18515    3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82

                         90
                 ....*....|....*
gi 256818756 514 QYAAELLAAVRLPFI 528
Cdd:cd18515   83 CYLSELLQTVRLALL 97

BTB_POZ_KLHL26

cd18255

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-436

4.34e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349564 [Multi-domain] Cd Length: 121 Bit Score: 83.60 E-value: 4.34e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLE 390
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQD-----EIELKGVSAKGLKHILD 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18255   76 FAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121

BACK_KLHL1

cd18509

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...

431-533

6.89e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350584 [Multi-domain] Cd Length: 106 Bit Score: 82.76 E-value: 6.89e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100
                 ....*....|....*....|...
gi 256818756 511 TRAQYAAELLAAVRLPFIHPSYL 533
Cdd:cd18509   82 RRCSDLSMLLAYIRLPLLPPQLL 104

BACK_KLHL21

cd18460

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...

431-528

7.61e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.

Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 82.54 E-value: 7.61e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*...
gi 256818756 511 TRAQYAAELLAAVRLPFI 528
Cdd:cd18460   81 HRQHFWPELLQHVRLPFV 98

BTB_POZ_ZBTB7A

cd18326

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-428

1.27e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349635 [Multi-domain] Cd Length: 120 Bit Score: 82.29 E-value: 1.27e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREklelvLSNLQADVLELL 388
Cdd:cd18326    6 PDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYE-----IDFVSAEALTAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18326   81 LDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

314-421

1.97e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 81.51 E-value: 1.97e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 314 EMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREKLELVLSnlqaDVLELLLEFVY 393
Cdd:cd18330    4 KLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTS----EAFSIILDFLY 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 256818756 394 TGSLVIDSANAKTLLEAASKFQFH---TFCK 421
Cdd:cd18330   80 SGKLDLCSENVIEVMSAASYLQMTdvvNFCK 110

BACK_KLHL28_BTBD5

cd18467

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...

431-528

2.28e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.

Pssm-ID: 350542 [Multi-domain] Cd Length: 99 Bit Score: 81.15 E-value: 2.28e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*...
gi 256818756 511 TRAQYAAELLAAVRLPFI 528
Cdd:cd18467   81 ERQKYLAQLLHCVRLPLL 98

BACK_KLHL7

cd18447

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...

430-527

3.80e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.

Pssm-ID: 350522 [Multi-domain] Cd Length: 98 Bit Score: 80.48 E-value: 3.80e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                         90
                 ....*....|....*...
gi 256818756 510 ATRAQYAAELLAAVRLPF 527
Cdd:cd18447   81 PNRQPYMVDILAKVRFPL 98

BACK_KLHL25_like

cd18464

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...

434-525

4.55e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350539 [Multi-domain] Cd Length: 98 Bit Score: 80.23 E-value: 4.55e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 434 SNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRA 513
Cdd:cd18464    3 SNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRH 82

                         90
                 ....*....|..
gi 256818756 514 QYAAELLAAVRL 525
Cdd:cd18464   83 EVLPELLRSVRL 94

BTB_POZ_KBTBD2_BKLHD1

cd18270

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

314-440

5.03e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349579 [Multi-domain] Cd Length: 133 Bit Score: 81.20 E-value: 5.03e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 314 EMLKELNQQrraKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLEFVY 393
Cdd:cd18270   15 EQLKFFYEQ---QLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQT-----HVHLRNVDAATLQIIITYAY 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 256818756 394 TGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVL 440
Cdd:cd18270   87 TGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133

BACK_KBTBD12

cd18485

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

431-530

6.87e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350560 [Multi-domain] Cd Length: 100 Bit Score: 79.77 E-value: 6.87e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18485    1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                         90       100
                 ....*....|....*....|
gi 256818756 511 TRAQYAAELLAAVRLPFIHP 530
Cdd:cd18485   81 SRVQHLVELLKQVRLELVSP 100

BTB_POZ_ZBTB7C_ZBTB36

cd18328

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-428

6.99e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349637 [Multi-domain] Cd Length: 120 Bit Score: 80.31 E-value: 6.99e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVqDSSQSSREKLELVlsnlQADVLELL 388
Cdd:cd18328    6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGT-LADQPYVYEIDFV----TPEALSAI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18328   81 LEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120

BTB_POZ_ZBTB7B_ZBTB15

cd18327

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-428

8.60e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349636 [Multi-domain] Cd Length: 127 Bit Score: 80.27 E-value: 8.60e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLI----QRSVQDSSQSSREKLELVLsnLQADV 384
Cdd:cd18327    6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFtgggGGSGDLGAGGGQDVCELDF--VGPEA 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 256818756 385 LELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18327   84 LGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB_POZ_KLHL41_KBTBD10

cd18341

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

313-439

1.03e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349650 [Multi-domain] Cd Length: 133 Bit Score: 80.28 E-value: 1.03e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 313 KEMLKElnqqrraKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdSSQSSREKLELVLSNLQADVLELLLEFV 392
Cdd:cd18341   19 KELLDE-------NKFVDCTLKAGDKSLPCHRLILAACSPYFREYFL-----SEESEEKKKEVVLDNVDPNIMDMILKYL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 256818756 393 YTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18341   87 YSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133

BACK_KLHL5

cd18511

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...

430-533

1.21e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.

Pssm-ID: 350586 [Multi-domain] Cd Length: 106 Bit Score: 79.34 E-value: 1.21e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....
gi 256818756 510 ATRAQYAAELLAAVRLPFIHPSYL 533
Cdd:cd18511   81 EQRRKDLSKLLAYIRLPLLAPQFL 104

BACK_KLHL30

cd18469

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...

429-532

1.25e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.

Pssm-ID: 350544 [Multi-domain] Cd Length: 104 Bit Score: 79.03 E-value: 1.25e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 429 KQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKD 508
Cdd:cd18469    1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                         90       100
                 ....*....|....*....|....
gi 256818756 509 PATRAQYAAELLAAVRLPFIHPSY 532
Cdd:cd18469   81 PQARAAHLPELLSLVHLSLLTDQY 104

BTB_POZ_ZBTB46

cd18230

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-434

1.48e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349539 [Multi-domain] Cd Length: 125 Bit Score: 79.72 E-value: 1.48e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREKLELVlsnlQADVLELL 388
Cdd:cd18230    2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIV----TAQGFKAI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTAS 434
Cdd:cd18230   78 IDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123

BTB_POZ_KLHL2-like

cd18235

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-431

2.16e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349544 [Multi-domain] Cd Length: 121 Bit Score: 79.01 E-value: 2.16e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsVQDSSQSSREKleLVLSNLQADVLELL 388
Cdd:cd18235    2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMF---TGDLSESRANR--VTLQDVDGKALLLL 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18235   77 IDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQL 119

BTB_POZ_KBTBD8

cd18274

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

308-439

3.42e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349583 [Multi-domain] Cd Length: 129 Bit Score: 78.49 E-value: 3.42e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 308 DPGHPKEMLKELNQQRRAKAFTDlkIVVE---GREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADV 384
Cdd:cd18274    2 DPLHACSILQQLKAMYDEGQLTD--IVVEvdhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQK-----EVRIVGVEAES 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 256818756 385 LELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18274   75 MHLVLDYAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129

BACK_KLHL25_ENC2

cd18514

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...

431-528

3.76e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).

Pssm-ID: 350589 [Multi-domain] Cd Length: 99 Bit Score: 77.58 E-value: 3.76e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*...
gi 256818756 511 TRAQYAAELLAAVRLPFI 528
Cdd:cd18514   81 KRKDYLPELLRNVRLALL 98

BACK_KLHL17

cd18456

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...

431-528

4.73e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.

Pssm-ID: 350531 [Multi-domain] Cd Length: 102 Bit Score: 77.35 E-value: 4.73e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90
                 ....*....|....*...
gi 256818756 511 TRAQYAAELLAAVRLPFI 528
Cdd:cd18456   81 GRRQHVPRLMKCVRLPLL 98

BTB_POZ_ZBTB30_HIC2

cd18334

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-429

4.96e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349643 [Multi-domain] Cd Length: 120 Bit Score: 78.09 E-value: 4.96e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsVQDSsqssreklelvLSNLQAD----- 383
Cdd:cd18334    2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLV---LHDN-----------LINLDTDmvnpt 67

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 256818756 384 VLELLLEFVYTGSLVIDSA----NAKTLLEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18334   68 VFRQILDFIYTGKLLTSDQpgeqNFNALLTAASYLQLHDLAALCRKKLKR 117

BACK_KLHL40_like

cd18477

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...

431-524

5.84e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

Pssm-ID: 350552 [Multi-domain] Cd Length: 99 Bit Score: 76.80 E-value: 5.84e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....
gi 256818756 511 TRAQYAAELLAAVR 524
Cdd:cd18477   81 NRQKALPTVFESIR 94

BACK_KLHL20

cd18459

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...

430-528

6.52e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.

Pssm-ID: 350534 [Multi-domain] Cd Length: 100 Bit Score: 76.70 E-value: 6.52e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18459    1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                         90
                 ....*....|....*....
gi 256818756 510 ATRAQYAAELLAAVRLPFI 528
Cdd:cd18459   81 QERRPHLPQVLQHVRLPLL 99

BTB_POZ_KLHL1-like

cd18234

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

329-437

6.70e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349543 [Multi-domain] Cd Length: 105 Bit Score: 77.02 E-value: 6.70e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 329 TDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLL 408
Cdd:cd18234    2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEE-----EIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLL 76

                         90       100
                 ....*....|....*....|....*....
gi 256818756 409 EAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18234   77 ATACLLQLSEVVEACCGFLMKQLHPSNCL 105

BTB_POZ_KLHL6

cd18236

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

306-438

7.95e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349545 [Multi-domain] Cd Length: 129 Bit Score: 77.58 E-value: 7.95e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 306 FTDPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVqdssqssREKLE--LVLSNLQAD 383
Cdd:cd18236    2 FDDTGLSLVLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDL-------KEKYEekIIIKGVDAE 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 256818756 384 VLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Cdd:cd18236   75 TMQILLDYTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129

BTB_POZ_KLHL3

cd18339

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

308-431

1.36e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349648 [Multi-domain] Cd Length: 121 Bit Score: 76.68 E-value: 1.36e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 308 DPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsVQDSSQSSREKLElvLSNLQADVLEL 387
Cdd:cd18339    1 NPAHMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMF---TGDMSESKAKKIE--IKDVDGQTLSK 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 256818756 388 LLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18339   76 LIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119

BACK_KLHL4

cd18510

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...

430-533

2.39e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350585 [Multi-domain] Cd Length: 106 Bit Score: 75.34 E-value: 2.39e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 430 QLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100
                 ....*....|....*....|....
gi 256818756 510 ATRAQYAAELLAAVRLPFIHPSYL 533
Cdd:cd18510   81 QNRQKDLGMLLSYIRLPLLPPQLL 104

BACK_KLHL41_KBTBD10

cd18517

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...

431-524

2.66e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.

Pssm-ID: 350592 [Multi-domain] Cd Length: 99 Bit Score: 75.19 E-value: 2.66e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                         90
                 ....*....|....
gi 256818756 511 TRAQYAAELLAAVR 524
Cdd:cd18517   81 NRVKSLGEIFDCIR 94

BTB_POZ_ZBTB44

cd18228

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-431

2.67e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349537 [Multi-domain] Cd Length: 126 Bit Score: 76.05 E-value: 2.67e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLI--QRSVQDSSQSSREKLELVLSNLQADVLELL 388
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLvgQASPRLVLVSPAGKCVLDLHHVTVTGFAPL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18228   82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124

BTB_POZ_KLHL31_KBTBD1

cd18260

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-437

3.66e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349569 [Multi-domain] Cd Length: 120 Bit Score: 75.23 E-value: 3.66e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSvqdssqSSREKLElvLSNLQADVLELLLE 390
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKD------PSLQRVE--LNDISPLGLATVIT 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18260   73 YAYTGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119

BTB_POZ_KLHL19_KEAP1

cd18248

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

310-431

4.08e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349557 [Multi-domain] Cd Length: 124 Bit Score: 75.49 E-value: 4.08e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 310 GHPKEMLKELNQQRRAKAFTDLKIVVEGR----EFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVL 385
Cdd:cd18248    3 DHTKEAFQIMNELRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSGLRECGME-----VVPIEGVHPCVM 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 256818756 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18248   78 SRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123

BACK_KLHL6

cd18446

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...

431-538

4.27e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Pssm-ID: 350521 [Multi-domain] Cd Length: 108 Bit Score: 74.81 E-value: 4.27e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                         90       100
                 ....*....|....*....|....*...
gi 256818756 511 TRAQYAAELLAAVRLPFIHPSYLLNVVD 538
Cdd:cd18446   81 ERLPLLPRVLENVRLPLLDPWYFVETVE 108

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-426

5.19e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 74.41 E-value: 5.19e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFkdliqRSVQDSSQSSreklELVLSNLQADVLELLLE 390
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFF-----QSLYGDGTSG----SVVLPESFAEVFGLLLD 71

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSF 426
Cdd:cd18232   72 FFYTGELALTRENRDRVLLAAKELRVPEAVELCQRF 107

BTB_POZ_ZBTB38_CIBZ

cd18223

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-429

1.03e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349532 [Multi-domain] Cd Length: 114 Bit Score: 74.05 E-value: 1.03e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqdSSQ---SSREKLElvLSNLQADVLEL 387
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAF------SSQeiwISSHVLE--LPDLKAEVFAE 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 256818756 388 LLEFVYTGSLVIDSANAKTLLEAASKfqfhtfcKVCVSFLEK 429
Cdd:cd18223   73 ILNFIYSSKVVVKRQETVTDLVAAGK-------KLGITFLEN 107

BTB_POZ_KBTBD3_BKLHD3

cd18271

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

310-437

1.46e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349580 [Multi-domain] Cd Length: 130 Bit Score: 74.10 E-value: 1.46e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 310 GHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSrekleLVLSNLQADVLELLL 389
Cdd:cd18271    6 CHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGS-----VTISNLSPKAVKAFL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 256818756 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18271   81 DYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128

BACK_KBTBD2

cd18479

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

431-525

2.78e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.

Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 72.01 E-value: 2.78e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                         90
                 ....*....|....*
gi 256818756 511 TRAQYAAELLAAVRL 525
Cdd:cd18479   81 SRSQYLSSVLSQIRI 95

BACK_KLHL23

cd18462

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...

431-533

3.88e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.

Pssm-ID: 350537 [Multi-domain] Cd Length: 102 Bit Score: 71.69 E-value: 3.88e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18462    1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                         90       100
                 ....*....|....*....|...
gi 256818756 511 TRAQYAAELLAAVRLPfIHPSYL 533
Cdd:cd18462   81 KRIECAYDLLSSIKLD-LDEIYL 102

PHA02790

Kelch-like protein; Provisional

331-787

4.88e-15

Kelch-like protein; Provisional

Pssm-ID: 165153 [Multi-domain] Cd Length: 480 Bit Score: 78.55 E-value: 4.88e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 331 LKIVVE--GREFEVHQNVLASCSLYFKD-LIQRSVQDSSQSSREKLELVLSNLQADVLellleFVYTGSLVIDSANAKTL 407
Cdd:PHA02790  22 FKTIIEaiGGNIIVNSTILKKLSPYFRThLRQKYTKNKDPVTRVCLDLDIHSLTSIVI-----YSYTGKVYIDSHNVVNL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 408 LEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVaaQEEIlsISKDDFIAY---V 484
Cdd:PHA02790  97 LRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLEL--EDDI--IDNFDYLSMkliL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 485 SNDSLNTKAEELVYETVIKWIKKDPATRAQYAAELLAAVRLPFIHPSYLLNV---VDNEELIKsseaCRDLVNEAKRYHM 561
Cdd:PHA02790 173 ESDELNVPDEDYVVDFVIKWYMKRRNRLGNLLLLIKNVIRSNYLSPRGINNVkwiLDCTKIFH----CDKQPRKSYKYPF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 562 LPHARQEMQTPRT-RPRLSAGVAEVIVLVGGrQMVGMTQRSLVAVTCwnpQNNKWYPLASLPfYDREFFSVVSAGDNIYL 640
Cdd:PHA02790 249 IEYPMNMDQIIDIfHMCTSTHVGEVVYLIGG-WMNNEIHNNAIAVNY---ISNNWIPIPPMN-SPRLYASGVPANNKLYV 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 641 SGGMESGVTLaDVWCYMSllDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGlgvagnvdHVERyDTIT-------NQWEAV 713
Cdd:PHA02790 324 VGGLPNPTSV-ERWFHGD--AAWVNMPSLLKPRCNPAVASINNVIYVIGG--------HSET-DTTTeyllpnhDQWQFG 391

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256818756 714 APLPKAVHSAAATVCGGKIYVfggvneAGRAAgvlQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAY 787
Cdd:PHA02790 392 PSTYYPHYKSCALVFGRRLFL------VGRNA---EFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFY 456

BTB_POZ_KLHL2_Mayven

cd18338

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

308-431

6.25e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349647 [Multi-domain] Cd Length: 121 Bit Score: 72.03 E-value: 6.25e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 308 DPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLEL 387
Cdd:cd18338    1 NPRHMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAK-----RVRIKEVDGWTLKM 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 256818756 388 LLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18338   76 LIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119

BTB_POZ_KBTBD12

cd18276

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-439

6.98e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349585 [Multi-domain] Cd Length: 127 Bit Score: 72.14 E-value: 6.98e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLE 390
Cdd:cd18276    4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQR-----EVVLHDITAESVSIILN 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18276   79 YMYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127

BTB_POZ_KLHL16_gigaxonin

cd18245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

315-428

7.12e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349554 [Multi-domain] Cd Length: 111 Bit Score: 71.22 E-value: 7.12e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSvQDSSQSSREKLElvLSNLQADVLELLLEFVYT 394
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYN-PPKDDGSTYKIE--LEGISVEVMEEILDYIYT 77

                         90       100       110
                 ....*....|....*....|....*....|....
gi 256818756 395 GSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18245   78 GQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111

BTB_POZ_ZBTB17_MIZ1

cd18206

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-426

9.59e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349515 [Multi-domain] Cd Length: 112 Bit Score: 71.11 E-value: 9.59e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLI--QRSVqdssqssrekLELVLSNlqADVLE 386
Cdd:cd18206    3 PQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFvdQKDV----------VHLDISN--AAGLG 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 256818756 387 LLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSF 426
Cdd:cd18206   71 QVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

BTB_POZ_ZBTB10

cd18201

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

314-431

9.67e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349510 [Multi-domain] Cd Length: 122 Bit Score: 71.53 E-value: 9.67e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 314 EMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDS-SQSSREKLELVlsnlQADVLELLLEFV 392
Cdd:cd18201    7 QLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKEScDQTTVTHLDVV----AVQGFSVILDFM 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 256818756 393 YTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18201   83 YSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121

BACK_KLHL40_KBTBD5

cd18516

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...

431-525

1.03e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 70.56 E-value: 1.03e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18516    1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQE 80

                         90
                 ....*....|....*
gi 256818756 511 TRAQYAAELLAAVRL 525
Cdd:cd18516   81 ERTKALPVLLESIRF 95

BTB_POZ_KLHL11

cd18241

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

306-436

1.28e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349550 [Multi-domain] Cd Length: 135 Bit Score: 71.43 E-value: 1.28e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 306 FTDPGHPKEMLKELNQQRRAKAFTDLKIVV---EGREFEVHQNVLASCSLYFKDLIQRSVQDSsQSSREKLELVLSN--L 380
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFggaGGREFRAHRSVLAAATEYFTPLLSGQFSES-RSGRVEMRKWSSEpgP 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 256818756 381 QADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18241   80 DPDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135

BTB_POZ_ZBTB31_myoneurin

cd18217

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-423

2.81e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349526 [Multi-domain] Cd Length: 111 Bit Score: 69.78 E-value: 2.81e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFkdliqrsvqdSSQSSREKLELVL---SNLQADVLEL 387
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYF----------GAQYKDTEDNIVFldqSQVSADGFQK 70

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 256818756 388 LLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18217   71 LLEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106

BTB_POZ_ZBTB11

cd18202

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

310-425

2.85e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349511 [Multi-domain] Cd Length: 118 Bit Score: 69.88 E-value: 2.85e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 310 GHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsVQDSSQSSREKLeLVLSNLQADVLELLL 389
Cdd:cd18202    1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELF---IEKGAVSSHEAV-VDLSGFCKSSFLPLL 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 256818756 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
Cdd:cd18202   77 EFAYTSELTFDFCSMAEVAMLARHLFMNEVLEICES 112

BTB_POZ_ZBTB18_2-like

cd18325

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-431

4.68e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349634 [Multi-domain] Cd Length: 128 Bit Score: 69.68 E-value: 4.68e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKdLIQRSVQDssqsSREKLELVLSNLQADVLELL 388
Cdd:cd18325    4 PDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFH-LFYRDQLD----KRDIVHLNSDIVTAPAFSLL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL-EKQL 431
Cdd:cd18325   79 LEFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLkDKEL 122

BTB_POZ_ZBTB29-like

cd18216

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-429

7.74e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349525 [Multi-domain] Cd Length: 118 Bit Score: 68.71 E-value: 7.74e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsVQDSsqssreklelvLSNLQAD----- 383
Cdd:cd18216    1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLV---LHDN-----------LIHLDQDmvspt 66

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 256818756 384 VLELLLEFVYTGSLvIDSA----NAKTLLEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18216   67 VFQQILDFIYTGKL-LDSLfeepNLSEVLAAANYLQLPDLAALCRSKLKR 115

BACK_KBTBD8

cd18483

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

431-526

8.89e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.

Pssm-ID: 350558 [Multi-domain] Cd Length: 97 Bit Score: 67.96 E-value: 8.89e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                         90
                 ....*....|....*..
gi 256818756 511 TRAQYAAELLA-AVRLP 526
Cdd:cd18483   81 KREMHLPEIFAkCIRMP 97

BACK_KLHL16_gigaxonin

cd18455

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...

432-524

1.11e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

Pssm-ID: 350530 [Multi-domain] Cd Length: 97 Bit Score: 67.34 E-value: 1.11e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 432 TASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPAT 511
Cdd:cd18455    1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80

                         90
                 ....*....|...
gi 256818756 512 RAQYAAELLAAVR 524
Cdd:cd18455   81 RKVHLKDLMSSCW 93

BTB_POZ_KLHL5

cd18337

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

306-439

1.55e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349646 [Multi-domain] Cd Length: 130 Bit Score: 68.16 E-value: 1.55e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 306 FTDPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVL 385
Cdd:cd18337    1 FQALNHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQE-----EIKMEGVEPNAL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 256818756 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18337   76 WALVQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129

BTB_POZ_KLHL18

cd18247

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

312-430

1.88e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349556 [Multi-domain] Cd Length: 116 Bit Score: 67.31 E-value: 1.88e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 312 PKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLEF 391
Cdd:cd18247    3 PSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQD-----EITMQGIEPSALEALINF 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 256818756 392 VYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
Cdd:cd18247   78 AYSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116

BTB_POZ_KLHL4

cd18336

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-439

2.53e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349645 [Multi-domain] Cd Length: 126 Bit Score: 67.38 E-value: 2.53e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLE 390
Cdd:cd18336    2 HAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQE-----EIKMEGVDPDALKALVH 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18336   77 YAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125

BTB_POZ_KLHL36

cd18266

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

304-437

2.54e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349575 [Multi-domain] Cd Length: 135 Bit Score: 67.61 E-value: 2.54e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 304 YEFTDpgHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreKLELVLSNLQAd 383
Cdd:cd18266    3 YRWAD--HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQK---EVELVGASYIG- 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 256818756 384 vLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18266   77 -LKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYL 129

BTB_POZ_KLHL17_actinfilin

cd18246

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-431

4.60e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349555 [Multi-domain] Cd Length: 139 Bit Score: 67.36 E-value: 4.60e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLE 390
Cdd:cd18246   22 HYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQT-----HVTLHDIDPQALEQLVQ 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18246   97 YAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 137

BTB_POZ_ZBTB4

cd18195

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-413

4.63e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349504 [Multi-domain] Cd Length: 124 Bit Score: 66.84 E-value: 4.63e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRS----------VQDSSQSSREKLElvLSNL 380
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPlplgaaavaaAPGATQSPERVLE--LPGV 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 256818756 381 QADVLELLLEFVYTGSLVIDSANAKTLLEAASK 413
Cdd:cd18195   79 KAGVFSDVLNFIYSSRVALPGSAAAKELGAAGK 111

BTB_POZ_ZBTB35_ZNF131

cd18221

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-415

5.55e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349530 [Multi-domain] Cd Length: 113 Bit Score: 66.18 E-value: 5.55e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFkdliQRSVQDSSQSSREKLELVlSNLqadVLELLLE 390
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFF----YKFFQDFTQEPLVEIEGV-SNM---AFRHLIE 72

                         90       100
                 ....*....|....*....|....*.
gi 256818756 391 FVYTGSLVI-DSANAKTLLEAASKFQ 415
Cdd:cd18221   73 FTYTAKLMVqGEEEANDVWKAAEYLQ 98

BTB_POZ_KLHL32

cd18261

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-437

6.16e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 66.53 E-value: 6.16e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSsqssrEKLELVLSNLQADVLELLLE 390
Cdd:cd18261   11 HKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVES-----EADEVNLHGVTSLGLKQALD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18261   86 FAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132

BTB_POZ_ZBTB18_RP58

cd18324

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

305-433

8.03e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349633 [Multi-domain] Cd Length: 147 Bit Score: 66.60 E-value: 8.03e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 305 EFtdPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYF----KDLIQRsvqdssqssREKLELVLSNL 380
Cdd:cd18324    2 EF--PDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFhlfyKDQLDK---------RDIVHLNSDIV 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 256818756 381 QADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTA 433
Cdd:cd18324   71 TAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATT 123

BTB_POZ_ZBTB39

cd18224

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

310-425

8.26e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349533 [Multi-domain] Cd Length: 123 Bit Score: 66.01 E-value: 8.26e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 310 GHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsrekleLVLSNLQADVLELLL 389
Cdd:cd18224    8 DHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVART------YVVDFITPANFEKVL 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 256818756 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
Cdd:cd18224   82 SFIYTSELFTDLINVGVIYEVAEKLGMEDLLKACHS 117

BACK_KLHL27_IPP

cd18466

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...

434-533

1.27e-12

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.

Pssm-ID: 350541 [Multi-domain] Cd Length: 103 Bit Score: 64.81 E-value: 1.27e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 434 SNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRA 513
Cdd:cd18466    4 ANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRK 83

                         90       100
                 ....*....|....*....|
gi 256818756 514 QYAAELLAAVRLPFIHPSYL 533
Cdd:cd18466   84 KHVVEVLEPVRFPLLPPQRL 103

BTB_POZ_ZBTB5

cd18196

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-427

1.65e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349505 [Multi-domain] Cd Length: 126 Bit Score: 65.07 E-value: 1.65e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrSVQDSSQsSREKLELVLSNLQADVLELL 388
Cdd:cd18196    2 PGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALF--TVAEGDQ-TMNMIQLDSEVVTAEAFAAL 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18196   79 IDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 117

BTB_POZ_ZBTB49

cd18233

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-428

2.32e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349542 [Multi-domain] Cd Length: 112 Bit Score: 64.14 E-value: 2.32e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvQDSSQSSREKLELVLSNLQAdvLELLLE 390
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLF----QNSSSQKNDVFHLDIKNVGG--IGQILD 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18233   75 FMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112

BTB_POZ_ZBTB3-like

cd18194

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

305-434

2.52e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349503 [Multi-domain] Cd Length: 128 Bit Score: 64.84 E-value: 2.52e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 305 EFtdPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKdLIQRSVQDSSQSSREKLELVlsnlQADV 384
Cdd:cd18194    2 EF--PEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LFYRDRLDKRDLVRLNSDIV----TAPA 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 256818756 385 LELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTAS 434
Cdd:cd18194   75 FGLLLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKALAE 124

BTB_POZ_BAB-like

cd18315

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

328-415

4.42e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349624 [Multi-domain] Cd Length: 85 Bit Score: 62.57 E-value: 4.42e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdsSQSSREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLK------ETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESL 74


                 ....*...
gi 256818756 408 LEAASKFQ 415
Cdd:cd18315   75 LKLAELLQ 82

BTB_POZ_trishanku-like

cd18314

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

328-423

5.74e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 62.75 E-value: 5.74e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSqssreKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18314    6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESN-----LKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDL 80

                         90
                 ....*....|....*.
gi 256818756 408 LEAASKFQFHTFCKVC 423
Cdd:cd18314   81 LMLASKYQVPDLEKLC 96

BTB_POZ_ZBTB3

cd18323

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

305-445

6.11e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349632 [Multi-domain] Cd Length: 128 Bit Score: 63.69 E-value: 6.11e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 305 EFtdPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFkdliqrsvQDSSQSSREKLELVLSNLQ--- 381
Cdd:cd18323    2 EF--PDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFF--------HMFYKEQLDKRDLVCINNEivt 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256818756 382 ADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCvsflEKQLTASnclgvlAMAEA 445
Cdd:cd18323   72 APAFSLLLEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVC----KKRLQAR------ALAEA 125

BTB_POZ_ZBTB14

cd18204

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-423

6.75e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349513 [Multi-domain] Cd Length: 114 Bit Score: 63.13 E-value: 6.75e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsrekleLVLSNLQADVLELLLE 390
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSV------IEIDFLRSDIFEEVLN 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18204   75 YMYTAKISVKKEDVNLMMSSGQILGIRFLDKLC 107

BTB_POZ_ABTB2-like

cd18297

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

328-435

6.85e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349606 [Multi-domain] Cd Length: 117 Bit Score: 63.06 E-value: 6.85e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqDSSQSSREKLELVLSNLQADVLELLLEFVYTG---SLVIDSANA 404
Cdd:cd18297   12 MSDVTFLVEGRPFYAHKIVLVTASDRFKSML-----SSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGgveSLDVAQDDA 86

                         90       100       110
                 ....*....|....*....|....*....|.
gi 256818756 405 KTLLEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18297   87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB_POZ_KLHL14_printor

cd18243

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

308-435

7.27e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349552 [Multi-domain] Cd Length: 130 Bit Score: 63.52 E-value: 7.27e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 308 DPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrSVQDssqssrekleLVLSNLQADVLEL 387
Cdd:cd18243   12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF--SINN----------LVLQGCSSIGLRL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 256818756 388 LLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18243   80 VLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127

BTB_POZ_KLHL1

cd18335

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-439

7.88e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349644 [Multi-domain] Cd Length: 126 Bit Score: 63.14 E-value: 7.88e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLE 390
Cdd:cd18335    2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQE-----EIKMEGIDPNALWDLVQ 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18335   77 FAYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125

BTB_POZ_ZBTB41

cd18226

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-411

8.35e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349535 [Multi-domain] Cd Length: 114 Bit Score: 62.89 E-value: 8.35e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQR-RAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklelvLSNLQADVLELLL 389
Cdd:cd18226    4 YNKNLLKYLNDDRqKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTDAVT--------LDHVSYSVFQHLL 75

                         90       100
                 ....*....|....*....|..
gi 256818756 390 EFVYTGSLVIDSANAKTLLEAA 411
Cdd:cd18226   76 EFLYTSEFFVYENEIPLVLEAA 97

BTB_POZ_BTBD19

cd18294

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

313-427

8.73e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349603 [Multi-domain] Cd Length: 111 Bit Score: 62.65 E-value: 8.73e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 313 KEMLKELNQQRrakaFTDLKIVV--EGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSreklELVLSNLQADVLELLLE 390
Cdd:cd18294    3 ADMKSLINNPE----FSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTQS----PLVLSDIEPEVFRAVLE 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18294   75 FIYTNCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111

BTB_POZ_BACH2

cd18278

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

304-427

1.28e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349587 [Multi-domain] Cd Length: 124 Bit Score: 62.66 E-value: 1.28e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 304 YEFTDPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYF-KDLIQRSVQDSSQSSREKlelvlsnLQA 382
Cdd:cd18278    7 YVYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFlQALVGQTENDLVVSLPEE-------VTA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 256818756 383 DVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18278   80 RGFGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB_POZ_ZBTB29_HIC1

cd18333

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-429

1.28e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349642 [Multi-domain] Cd Length: 121 Bit Score: 62.61 E-value: 1.28e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsVQDSsqssreklelvLSNLQAD----- 383
Cdd:cd18333    2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLV---VHDN-----------LINLDHEmvspg 67

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 256818756 384 VLELLLEFVYTGSLV-IDSANAKTL---LEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18333   68 IFRLILDYIYTGRLSeGDPGSEQNLgavLAAASYLQIPDLVALCKKKLKR 117

BTB_POZ_KBTBD4

cd18272

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

304-440

1.33e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349581 [Multi-domain] Cd Length: 140 Bit Score: 62.99 E-value: 1.33e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 304 YEFTDPGHPKEMLKE-LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSrekleLVLSNLQA 382
Cdd:cd18272    7 YTFTDRSHSSRVAQSiMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRV-----IELKDVSE 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 256818756 383 DVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVL 440
Cdd:cd18272   82 SVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQVM 139

BTB_POZ_BTBD14A_NAC2

cd18289

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-415

1.78e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349598 [Multi-domain] Cd Length: 131 Bit Score: 62.35 E-value: 1.78e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqdsSQSSREKLELVlSNLQADVLELL 388
Cdd:cd18289   10 PNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLF-------SGNSKSAFELP-ATVPPACFQQI 81

                         90       100
                 ....*....|....*....|....*..
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQ 415
Cdd:cd18289   82 LSFCYTGKLTMAASEQLVVMYTAGFLQ 108

BTB_POZ_BACH1

cd18277

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-427

2.08e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349586 [Multi-domain] Cd Length: 120 Bit Score: 62.01 E-value: 2.08e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqdSSQSSREKLELVLSNLQADVLELLLE 390
Cdd:cd18277   10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRI------VGQADAELNITLPEEVTVKGFEPLIQ 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18277   84 FAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB_POZ_ZBTB33_KAISO

cd18219

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

308-398

2.56e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349528 [Multi-domain] Cd Length: 106 Bit Score: 61.00 E-value: 2.56e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 308 DPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQdssqssreklELVLSNLQADVLEL 387
Cdd:cd18219    1 DTQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAGQ----------VVELNFIRADIFAE 70

                         90
                 ....*....|.
gi 256818756 388 LLEFVYTGSLV 398
Cdd:cd18219   71 ILNYIYSSKIV 81

BTB_POZ_ZBTB19_PATZ1

cd18207

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

304-423

3.18e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349516 [Multi-domain] Cd Length: 128 Bit Score: 61.52 E-value: 3.18e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 304 YEFTDPGHPKEMLKELNQQRRAKA-FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSreklELVLSNLQA 382
Cdd:cd18207    2 YTYQVSQHSADMLHNLNQQRKSGGrFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPR----ELEMHTISS 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 256818756 383 DVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18207   78 KVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDIC 118

BACK_KBTBD3

cd18480

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

434-512

3.24e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350555 [Multi-domain] Cd Length: 82 Bit Score: 60.03 E-value: 3.24e-11

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256818756 434 SNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATR 512
Cdd:cd18480    4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEAR 82

BTB_POZ_ZBTB42

cd18956

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

305-423

3.95e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349737 [Multi-domain] Cd Length: 129 Bit Score: 61.37 E-value: 3.95e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 305 EFtdPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKdLIQRsvqDSSQSSREKLELVLSNLQADV 384
Cdd:cd18956    2 EF--PEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYR---DRPAGGRDTVRLNGDIVTAPA 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 256818756 385 LELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18956   76 FGRLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVC 114

BTB_POZ_KLHL34

cd18264

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

321-436

7.24e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349573 [Multi-domain] Cd Length: 136 Bit Score: 60.58 E-value: 7.24e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 321 QQRRAKAF-TDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqDSSQSSREKLeLVLSNLQADVLELLLEFVYTGSLVI 399
Cdd:cd18264   20 QSLRAEGFlCDVVLEAEGNEFPAHRSLLACSSDYFRALFK----DYTQESKARV-IHLPVVSAAGLQRVLDFIYTSWLSL 94

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 256818756 400 DSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18264   95 SLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131

BTB_POZ_ZBTB43

cd18227

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

305-428

8.53e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349536 [Multi-domain] Cd Length: 121 Bit Score: 59.95 E-value: 8.53e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 305 EFtdPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliQRSVQDSSQssrekleLVLSN-LQAD 383
Cdd:cd18227    4 EF--PDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCD--QVLLKNSRR-------IVLPDvMNPR 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 256818756 384 VLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18227   73 VFENILLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117

BTB_POZ_calicin

cd18307

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

328-426

1.14e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349616 [Multi-domain] Cd Length: 97 Bit Score: 59.05 E-value: 1.14e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrSVQDSSQSSREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18307    1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLI--SSNDMKATDELSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDL 78

                         90
                 ....*....|....*....
gi 256818756 408 LEAASKFQFHTFCKVCVSF 426
Cdd:cd18307   79 LKGAKYFNIPRLKDHCVDF 97

BTB_POZ_BTBD18

cd18293

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

315-415

1.30e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349602 [Multi-domain] Cd Length: 120 Bit Score: 59.42 E-value: 1.30e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQssreKLELVLSNLQADVLELLLEFVYT 394
Cdd:cd18293    2 AFLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQ----KVVLELQGLKAHTLLKLVDFLYT 77

                         90       100
                 ....*....|....*....|.
gi 256818756 395 GSLVIDSANAKTLLEAASKFQ 415
Cdd:cd18293   78 SELEVSSEEAQDVLAAARRLQ 98

BACK_KLHL33

cd18472

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...

431-504

1.69e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 57.78 E-value: 1.69e-10

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKW 504
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRW 74

BTB_POZ_KLHL9_13

cd18239

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

306-436

3.59e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349548 [Multi-domain] Cd Length: 128 Bit Score: 58.66 E-value: 3.59e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 306 FTDPGHPKEMLKELNQQRRAKAFTDLKIVVEGRE--FEVHQNVLASCSLYFKDLIQRSVQDssqssREKLELVLSNLQAD 383
Cdd:cd18239    1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDetFPVHRAMMASASDYFKAMFTGGMKE-----QELMCIKLHGVSKI 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 256818756 384 VLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18239   76 GLKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128

BTB_POZ_ZBTB1

cd18192

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-417

3.93e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349501 [Multi-domain] Cd Length: 114 Bit Score: 57.91 E-value: 3.93e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQssrekleLVLSNLQ--ADVLE 386
Cdd:cd18192    2 PSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQ-------LNLSNMKisAECFD 74

                         90       100       110
                 ....*....|....*....|....*....|.
gi 256818756 387 LLLEFVYTGSLVIDSANAKTLLEAASKFQFH 417
Cdd:cd18192   75 LILQFMYLGKIMTAPSDFEQLKVAMNYLQLY 105

BTB_POZ_ZBTB37

cd18222

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-428

4.68e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349531 [Multi-domain] Cd Length: 123 Bit Score: 58.13 E-value: 4.68e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliQRSVQDSSQSSREklelVLSNlqADVLELL 388
Cdd:cd18222    6 PDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRD--HMSLNEMSTVSIS----VIKN--PTVFEQL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18222   78 LSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILE 117

BTB_POZ

cd01165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

332-414

4.69e-10

Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 56.52 E-value: 4.69e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 332 KIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAA 411
Cdd:cd01165    2 VLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQA-----EINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAA 76


                 ...
gi 256818756 412 SKF 414
Cdd:cd01165   77 NFL 79

BTB_POZ_ZBTB9

cd18200

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-429

5.35e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349509 [Multi-domain] Cd Length: 111 Bit Score: 57.56 E-value: 5.35e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsVQDSSQssrekleLVLSN-LQADVLELLL 389
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLL--LNDTNC-------LVLPSvIEAAAFENLL 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 256818756 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18200   72 QLIYSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELLKE 111

BACK

cd14733

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...

432-486

6.57e-10

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 55.36 E-value: 6.57e-10

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 256818756 432 TASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSN 486
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BTB_POZ_BACH

cd18955

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

330-427

7.26e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349736 [Multi-domain] Cd Length: 94 Bit Score: 56.71 E-value: 7.26e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 330 DLKIVVEGREFEVHQNVLASCSLYFkdlIQRSVQDSSQssreklELVLsNLQADV----LELLLEFVYTGSLVIDSANAK 405
Cdd:cd18955    3 DVTIVVEDQRFRAHRAVLAACSDYF---LSRVVGQTDG------DLVI-TLPEEVtvkgFEPLLQFAYTAKLLLSKENVL 72

                         90       100
                 ....*....|....*....|..
gi 256818756 406 TLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18955   73 EVCRCAEFLGVHNIEKACFDFL 94

BTB_POZ_BTBD17

cd18292

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

328-426

1.28e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349601 [Multi-domain] Cd Length: 114 Bit Score: 56.53 E-value: 1.28e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLI-QRSVQDSSQSsreKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKT 406
Cdd:cd18292   17 LSDIVLRVGGKVFHAHRLILAKSSDVFRVMLsNDWWSESKQS---EIELVEDPECAAVFEKFLRYLYTGQISVNLETALP 93

                         90       100
                 ....*....|....*....|
gi 256818756 407 LLEAASKFQFHTFCKVCVSF 426
Cdd:cd18292   94 LLMLADKYNVTDLKQLCVDF 113

BTB2_POZ_KLHL33

cd18263

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

316-437

1.43e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349572 [Multi-domain] Cd Length: 118 Bit Score: 56.36 E-value: 1.43e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 316 LKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLEFVYTG 395
Cdd:cd18263    1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQS-----VVQLPTIPAKDLRLLISFAYSG 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 256818756 396 SLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18263   76 ILHLSWENLFEATCTALQLQISGALALCLDFLQREISPARCL 117

BTB_POZ_BTBD14B_NAC1

cd18290

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-415

1.53e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349599 [Multi-domain] Cd Length: 123 Bit Score: 56.58 E-value: 1.53e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqdssQSSREKLELVLSNLQADVLELL 388
Cdd:cd18290    8 PNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF--------NSSRSAVVELPAAVQPQSFQQI 79

                         90       100
                 ....*....|....*....|....*..
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQ 415
Cdd:cd18290   80 LSFCYTGRLSMNVGDQFLLMYTAGFLQ 106

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

672-717

1.70e-09

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 53.77 E-value: 1.70e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 256818756  672 PRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLP 717
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ZBTB34

cd18220

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

305-428

1.81e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349529 [Multi-domain] Cd Length: 120 Bit Score: 56.19 E-value: 1.81e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 305 EFTDPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliqrsvqDSSQSSREKLEL-VLSNlqAD 383
Cdd:cd18220    2 QFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRD-------HSALSTMSGLSIsVIKN--PN 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 256818756 384 VLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18220   73 VFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117

BTB_POZ_ZBTB28_BCL6B

cd18332

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-428

2.18e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349641 [Multi-domain] Cd Length: 114 Bit Score: 56.02 E-value: 2.18e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqdSSQSSREKLELVL-SNLQADVLELLL 389
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIF------SGRVGEGVSVLTLpSGLEARGFQLLL 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 256818756 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLE 428
Cdd:cd18332   76 DFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114

BTB_POZ_SPOPL

cd18343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

328-435

3.12e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349652 [Multi-domain] Cd Length: 123 Bit Score: 55.78 E-value: 3.12e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREklelvLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18343   21 FTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVE-----INDVDPEVFKEMMRFIYTGKAPNLDKMADNL 95

                         90       100
                 ....*....|....*....|....*...
gi 256818756 408 LEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18343   96 LAAADKYALERLKVMCEEALCNNLSVEN 123

PHA03247

large tegument protein UL36; Provisional

39-290

3.98e-09

large tegument protein UL36; Provisional

Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 60.72 E-value: 3.98e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   39 AGGSTASSLSARPGLLPLPVVPSRlPTPATAPApctTGSSEAITSLVVSSASAATTKAPgiSKADNQSQGLTTSIRWGQT 118
Cdd:PHA03247 2745 PAGPATPGGPARPARPPTTAGPPA-PAPPAAPA---AGPPRRLTRPAVASLSESRESLP--SPWDPADPPAAVLAPAAAL 2818

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  119 PVNQsTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQ--PSLITHSYGVTQPPTFSPAVNVQAPVIGVT---PSLPPHV 193
Cdd:PHA03247 2819 PPAA-SPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSvaPGGDVRRRPPSRSPAAKPAAPARPPVRRLArpaVSRSTES 2897

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  194 GPQLPLIPGHYSLPQPPSQPLSSVVVNMPAQALYASPQ------PLAVSTLP-GVGQVSRPGPTPvGNGHMAGPLLPPPP 266
Cdd:PHA03247 2898 FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPpprpqpPLAPTTDPaGAGEPSGAVPQP-WLGALVPGRVAVPR 2976

                         250       260
                  ....*....|....*....|....
gi 256818756  267 PAQPSAALPSSVPATNGPPTTDSA 290
Cdd:PHA03247 2977 FRVPQPAPSREAPASSTPPLTGHS 3000

BTB_POZ_ZBTB24_ZNF450

cd18212

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-411

7.22e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349521 [Multi-domain] Cd Length: 118 Bit Score: 54.42 E-value: 7.22e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSvQDSSQSSrekleLVLSNLQADVLELLLE 390
Cdd:cd18212    6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADE-GEVGQSI-----YMLEGMVAETFGALLE 79

                         90       100
                 ....*....|....*....|.
gi 256818756 391 FVYTGSLVIDSANAKTLLEAA 411
Cdd:cd18212   80 FIYTGCLQVGEKSLEQILATA 100

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

431-509

7.68e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 53.28 E-value: 7.68e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18474    1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79

BTB_POZ_SPOP-like

cd18279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

328-435

8.69e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349588 [Multi-domain] Cd Length: 120 Bit Score: 54.46 E-value: 8.69e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREklelvLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18279   18 FTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVE-----INDVDPEVFKEMMRFIYTGKAPNLDKMADDL 92

                         90       100
                 ....*....|....*....|....*...
gi 256818756 408 LEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18279   93 LAAADKYALERLKVMCEDALCSNLSVEN 120

BTB_POZ_BTBD11

cd18351

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

326-437

9.34e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349660 [Multi-domain] Cd Length: 131 Bit Score: 54.60 E-value: 9.34e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 326 KAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqdSSQSSREKLELVLSNLQADVLELLLEFVYTG---SLVIDSA 402
Cdd:cd18351   22 KEMSDVTFLVEGRPFYAHKVLLFTASPRFKALL------SNKPSAENTCIEISYVKYHIFQLVMQYLYCGgteSLLIKNN 95

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 256818756 403 NAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18351   96 EIMELLSAAKFFQLEALQRHCEIICAKSINTENCV 130

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

329-435

1.05e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 54.02 E-value: 1.05e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 329 TDLKIVVEGREFEVHQNVLASCSLYFkdliqRSVQDSSQSSREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLL 408
Cdd:cd18352   14 SDVTFLVEGRRFYAHRIALLASSDAF-----RAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLL 88

                         90       100
                 ....*....|....*....|....*..
gi 256818756 409 EAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18352   89 RAADQYLLEGLKRLCEYTIAQDLTLEN 115

BTB_POZ_ZBTB21_ZNF295

cd18209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-409

1.25e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349518 [Multi-domain] Cd Length: 112 Bit Score: 53.72 E-value: 1.25e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSvQDSSQSSREklelvLSNLQADVLELLLE 390
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEK-ENESQSVFQ-----LDFCEPDAFENVLN 74

                         90
                 ....*....|....*....
gi 256818756 391 FVYTGSLVIDSANAKTLLE 409
Cdd:cd18209   75 YIYSSSLFVEKSSLAAVQE 93

BTB_POZ_KLHL15

cd18244

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

330-440

2.05e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349553 [Multi-domain] Cd Length: 137 Bit Score: 53.81 E-value: 2.05e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 330 DLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDssqssREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLE 409
Cdd:cd18244   32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRE-----RDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEILQ 106

                         90       100       110
                 ....*....|....*....|....*....|.
gi 256818756 410 AASKFQFHTFCKVCVSFLEKQLTASNCLGVL 440
Cdd:cd18244  107 AAMYVQLTEVVKFCCSFLLAKICLDNCAEIM 137

BTB_POZ_ZBTB47_ZNF651

cd18231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

316-430

2.30e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 53.00 E-value: 2.30e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 316 LKELNQQRRAK---AFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQdssqssREKLELVLSNLQADVLELLLEFV 392
Cdd:cd18231    1 MDRLNEQRLFQpdlCDVDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQ------LQRVELSLEALTSQGLQQILNFI 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 256818756 393 YTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
Cdd:cd18231   75 YTSKLLVNSCNVQDVLNAAAVLQMNDIAASCQELIDSR 112

BTB_POZ_ZBTB12

cd18203

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

306-423

2.91e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349512 [Multi-domain] Cd Length: 122 Bit Score: 52.96 E-value: 2.91e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 306 FTDPGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliQRSVQDSSQssrekLELVLSNLQADVL 385
Cdd:cd18203    3 FQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRD--QFLLNPSSE-----LQVSLMHSSRVVA 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 256818756 386 ELLLEfVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18203   76 DLLLS-CYTGALEFSVRDIVNYLTAASYLQMEHVVEKC 112

BTB_POZ_BTBD9

cd18287

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

328-416

2.96e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349596 [Multi-domain] Cd Length: 119 Bit Score: 52.62 E-value: 2.96e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreKLELVLSNLQAdvLELLLEFVYTGSLV---IDSANA 404
Cdd:cd18287   22 YSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQS---EIELKDTNAEA--FKALLKYIYTGRLTltdLKEDVL 96

                         90
                 ....*....|..
gi 256818756 405 KTLLEAASKFQF 416
Cdd:cd18287   97 LDVLGLAHQYGF 108

BTB_POZ_ZBTB27-like

cd18215

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-426

2.98e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349524 [Multi-domain] Cd Length: 113 Bit Score: 52.57 E-value: 2.98e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvQDSSQSSREKLELVlSNLQADVLELLLE 390
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIF----TDQLKNNVSVINLD-PEIEPEGFRILLD 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSF 426
Cdd:cd18215   77 FMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112

PRK14131

N-acetylneuraminate epimerase;

670-785

3.82e-08

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 56.56 E-value: 3.82e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 670 TVPRCRHNSLVYDGKIYTLGGLGVAGN------VDHVERYDTITNQWEAV---APLPKAVHSAAaTVCGGKIYVFGGVNE 740
Cdd:PRK14131  72 GGPREQAVAAFIDGKLYVFGGIGKTNSegspqvFDDVYKYDPKTNSWQKLdtrSPVGLAGHVAV-SLHNGKAYITGGVNK 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 741 A---------GRAAG-------------------------VLqSYVPQTNTWSFI-ESPMIDNKYAPAVTLNGFVFILGG 785
Cdd:PRK14131 151 NifdgyfedlAAAGKdktpkdkindayfdkkpedyffnkeVL-SYDPSTNQWKNAgESPFLGTAGSAVVIKGNKLWLING 229

BTB2_POZ_ABTB1_BPOZ1

cd18296

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

328-431

4.84e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349605 [Multi-domain] Cd Length: 121 Bit Score: 52.30 E-value: 4.84e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18296   17 FPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENNGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDV 96

                         90       100
                 ....*....|....*....|....
gi 256818756 408 LEAASKFQFHTFCKVCVSFLEKQL 431
Cdd:cd18296   97 LYVADMYLLPGLKRLCGTVLAQSL 120

BTB_POZ_ABTB2_BPOZ2

cd18350

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

326-437

5.18e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349659 [Multi-domain] Cd Length: 134 Bit Score: 52.54 E-value: 5.18e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 326 KAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSReklELVLSNLQADVLELLLEFVYTG---SLVIDSA 402
Cdd:cd18350   22 KEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEQESQGSK---TIEISDIKYHIFQMLMQYLYYGgteSMEIPIA 98

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 256818756 403 NAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 437
Cdd:cd18350   99 DVLELLSAASLFQLDALQRHCEILCSQTINLENAV 133

BTB1_POZ_KLHL33

cd18262

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

311-411

5.27e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349571 [Multi-domain] Cd Length: 101 Bit Score: 51.44 E-value: 5.27e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRsvqdssqSSREKLELVLSNLQADvLELLLE 390
Cdd:cd18262    1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLG-------SNGPLPPLSLEVTPVG-WEAVLT 72

                         90       100
                 ....*....|....*....|.
gi 256818756 391 FVYTGSLVIDSANAKTLLEAA 411
Cdd:cd18262   73 FAYTGVLGRNPATVGDILVAA 93

BTB_POZ_ZBTB45

cd18229

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

313-423

5.46e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349538 [Multi-domain] Cd Length: 112 Bit Score: 51.78 E-value: 5.46e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 313 KEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliqrsvqdssqssreKLELVLSNLQ------ADVLE 386
Cdd:cd18229    3 KSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHD---------------KLLLGHSEIEvppvvpAQTVR 67

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 256818756 387 LLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18229   68 QLVEFMYSGSLVVAQSEALQILTAASILQIKTVIDEC 104

Kelch

Kelch domain;

822-870

6.30e-08

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 49.48 E-value: 6.30e-08

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 256818756   822 KIYATGGIVSSEgpALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIKK 870
Cdd:smart00612   1 KIYVVGGFDGGQ--RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB16_PLZF

cd18205

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-427

6.90e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349514 [Multi-domain] Cd Length: 107 Bit Score: 51.57 E-value: 6.90e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQdssqssreklELVLSNLQADVLELLLE 390
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQ----------HYTLDFLSPKTFQQILE 70

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18205   71 YAYTATLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107

BTB1_POZ_IBtk

cd18301

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

330-396

7.45e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349610 [Multi-domain] Cd Length: 99 Bit Score: 51.13 E-value: 7.45e-08

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 256818756 330 DLKIVVEGREFEVHQNVLASCSLYFKDLIqRSVQDSSQSSREKLELVLSNLQADVLELLLEFVYTGS 396
Cdd:cd18301   20 DVVFQVGGKTFPAHKFILASRSDYFRKLF-LSSLLTSEDAVGCDVVHIEKVPPEIFEQLLQFIYTDT 85

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

811-857

9.40e-08

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 49.15 E-value: 9.40e-08

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 256818756  811 RQFCSAVVLDGKIYATGGIVSSEgpALGNMEAYEPTTNTWTLLPHMP 857
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQ--SLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ZBTB27_BCL6

cd18331

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-427

1.21e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349640 [Multi-domain] Cd Length: 118 Bit Score: 51.01 E-value: 1.21e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvqdssqSSREKLELVLSNLQADV----LE 386
Cdd:cd18331    7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIF---------TDQLKCNLSVINLDPEInpegFN 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 256818756 387 LLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18331   78 ILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118

PRK14131

N-acetylneuraminate epimerase;

682-785

1.32e-07

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 54.64 E-value: 1.32e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 682 DGKIYTlgGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHS-AAATVCGGKIYVFGGVNEAGrAAGVLQ------SYVPQ 754
Cdd:PRK14131  38 NNTVYV--GLGSAGTSWYKLDLNAPSKGWTKIAAFPGGPREqAVAAFIDGKLYVFGGIGKTN-SEGSPQvfddvyKYDPK 114

                         90       100       110
                 ....*....|....*....|....*....|...
gi 256818756 755 TNTWSFI--ESPMIDNKYAPAVTLNGFVFILGG 785
Cdd:PRK14131 115 TNSWQKLdtRSPVGLAGHVAVSLHNGKAYITGG 147

BTB_POZ_ZBTB23_GZF1

cd18211

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

312-431

1.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349520 [Multi-domain] Cd Length: 128 Bit Score: 51.01 E-value: 1.52e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 312 PKEMLKELNQQRRAKAFTDLKIVVE----GREFEVHQNVLASCSLYFKDL-IQRSVQDSSQSSrekleLVLSNLQADVLE 386
Cdd:cd18211    9 PSNLLNEMHKLRLLGHLCDVTVQVEhqgsKEEFSAHKAVLAASSKYFKEVfLNEKISDGKNTN-----VMLNEIYTADFA 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 256818756 387 LLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCvSFLEKQL 431
Cdd:cd18211   84 SFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETC-FQLKKQM 127

BTB_POZ_roadkill-like

cd18345

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

327-435

2.43e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349654 [Multi-domain] Cd Length: 121 Bit Score: 50.23 E-value: 2.43e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 327 AFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREklelvLSNLQADVLELLLEFVYTGSLVIDSANAKT 406
Cdd:cd18345   17 AFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVE-----ITDVDHEVMREMLRFIYTGKAPNLDKMADD 91

                         90       100
                 ....*....|....*....|....*....
gi 256818756 407 LLEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18345   92 LLAAADKYALERLKVMCEEALCSNLSVEN 120

BTB_POZ_KLHL22

cd18251

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-427

2.48e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349560 [Multi-domain] Cd Length: 125 Bit Score: 50.20 E-value: 2.48e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLE 390
Cdd:cd18251    6 HSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQT-----EVLIHGVSYNAMCKILD 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18251   81 FIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFL 117

BTB_POZ_SPOP

cd18342

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

328-435

2.53e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349651 [Multi-domain] Cd Length: 125 Bit Score: 50.49 E-value: 2.53e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 328 FTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREklelvLSNLQADVLELLLEFVYTGSLVIDSANAKTL 407
Cdd:cd18342   22 FTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVE-----INDVEPEVFKEMMCFIYTGKAPNLDKMADDL 96

                         90       100
                 ....*....|....*....|....*...
gi 256818756 408 LEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18342   97 LAAADKYALERLKVMCEDALCSNLSVEN 124

PHA03247

large tegument protein UL36; Provisional

39-250

2.66e-07

large tegument protein UL36; Provisional

Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.94 E-value: 2.66e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   39 AGGSTASSLSARPGLLPLPVVP----SRLPTPATAPAPCTTGSSEAITSLVVSSASAATTKAPGISKADNQSqglttsir 114
Cdd:PHA03247 2673 AAQASSPPQRPRRRAARPTVGSltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-------- 2744

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  115 wGQTPVNQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPSLITHSYGVTQPPTFSPAVNVQAPVIGVTPSLPPHVG 194
Cdd:PHA03247 2745 -PAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 256818756  195 PQLPLIPGHYSLPQPPSQPlssvvvnmpaQALYASPQPLAVSTLPGvGQVSRPGPT 250
Cdd:PHA03247 2824 PAGPLPPPTSAQPTAPPPP----------PGPPPPSLPLGGSVAPG-GDVRRRPPS 2868

BTB_POZ_CP190-like

cd18311

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

315-435

4.94e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349620 [Multi-domain] Cd Length: 110 Bit Score: 49.12 E-value: 4.94e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 315 MLKELNQQRRAKAFTDLKI-VVEGREFEVHQNVLASCSLYFkdliqrSVQDSSQSSREKLELVLSNLQADVLELLLEFVY 393
Cdd:cd18311    1 FLQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYF------NVLEQTCEIVDDTLIMPNELQADAVVPVINFMY 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 256818756 394 TGSLVIDSANAKTLLEAASKFQfhtfckvcVSFLEKQLTASN 435
Cdd:cd18311   75 TGQLEFEEKSYGKLLRTAKELN--------MTVLLKLLEAHR 108

BACK_KLHL26

cd18465

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...

431-528

6.03e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.

Pssm-ID: 350540 Cd Length: 97 Bit Score: 48.37 E-value: 6.03e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18465    1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80

                         90
                 ....*....|....*...
gi 256818756 511 TRAQyAAELLAAVRLPFI 528
Cdd:cd18465   81 RRAS-ASHVLCHIRFPLM 97

BACK_KBTBD6_7

cd18482

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...

431-524

6.21e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

Pssm-ID: 350557 [Multi-domain] Cd Length: 99 Bit Score: 48.27 E-value: 6.21e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEIL-SISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509
Cdd:cd18482    1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQLLAKEEELcELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                         90
                 ....*....|....*
gi 256818756 510 ATRAQYAAELLAAVR 524
Cdd:cd18482   81 KERAASAAEVLKCVR 95

BTB_POZ_NPR_plant

cd18310

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

327-439

6.95e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349619 [Multi-domain] Cd Length: 145 Bit Score: 49.61 E-value: 6.95e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 327 AFTDLKIVVE-GREFEVHQNVLASCSLYFKDLIQRSVQDSSqSSREKLEL--VL--SNLQADVLELLLEFVYTGSLvidS 401
Cdd:cd18310   17 FYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGA-NTKPKLELreLIpgGIVGYDAFMLVLSYLYSGRL---R 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 256818756 402 ANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
Cdd:cd18310   93 LVPKEGSACVDSDCWHVACRPAVDFALEVLYAASVFQI 130

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

799-857

8.48e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 51.70 E-value: 8.48e-07

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 256818756 799 GNIKAGPNMNHSRQFCSAVVLDGKIYATGGIvsSEGPALGNMEAYEPTTNTWTLLPHMP 857
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGL--SGGSASNSFEVYDPATNTWSELAPLP 57

BTB_POZ_ZBTB20_DPZF

cd18208

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

315-429

9.06e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349517 [Multi-domain] Cd Length: 117 Bit Score: 48.52 E-value: 9.06e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSqssreklelVLSNLQADVLELLLEFVYT 394
Cdd:cd18208   12 VLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIE---------IPSVVSVQSVQKLIDFMYS 82

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 256818756 395 GSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18208   83 GVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 117

BACK_KLHL9_13

cd18449

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...

435-526

1.02e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Pssm-ID: 350524 [Multi-domain] Cd Length: 95 Bit Score: 47.80 E-value: 1.02e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 435 NCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPAtRAQ 514
Cdd:cd18449    5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDD-RMQ 83

                         90
                 ....*....|..
gi 256818756 515 YAAELLAAVRLP 526
Cdd:cd18449   84 FAAKLMENIRFP 95

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

330-427

1.85e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 47.66 E-value: 1.85e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 330 DLKIVVEGREFEVHQNVLASCSlYFKDLIQRSVQDSSQSsREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLE 409
Cdd:cd18305   17 DITICALGREWKLHKIYLCQSG-YFASMFSGSWKESKET-VINLEIPDDNITVEALNVVFGSLYRDEIEIKPSRVVSILA 94

                         90
                 ....*....|....*...
gi 256818756 410 AASKFQFHTFCKVCVSFL 427
Cdd:cd18305   95 AATLLQLDGLIQQCSEVM 112

BTB_POZ_ZBTB40

cd18225

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

309-427

2.00e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349534 [Multi-domain] Cd Length: 116 Bit Score: 47.51 E-value: 2.00e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 309 PGHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSreklelVLSnlqADVLELL 388
Cdd:cd18225    4 PNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDAS------VVS---PEEFALL 74

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 256818756 389 LEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18225   75 LEMVYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLL 113

BTB_POZ_ZBTB22_BING1

cd18210

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

315-427

2.11e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349519 [Multi-domain] Cd Length: 112 Bit Score: 47.14 E-value: 2.11e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliQRSVQDSSQSSrekLELVLSNLqadVLELLLEFVYT 394
Cdd:cd18210    8 LLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHD--QVLLKNMSSIS---LPGVMDPG---AFESVLASAYT 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 256818756 395 GSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18210   80 GKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BACK_KLHL31_KBTBD1

cd18470

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...

431-525

2.55e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Pssm-ID: 350545 Cd Length: 98 Bit Score: 46.79 E-value: 2.55e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDpA 510
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-Q 79

                         90
                 ....*....|....*
gi 256818756 511 TRAQYAAELLAAVRL 525
Cdd:cd18470   80 KRVKYAADLLSNIRF 94

BTB_POZ_ZBTB32_FAZF_TZFP

cd18218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-423

2.57e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349527 [Multi-domain] Cd Length: 110 Bit Score: 46.86 E-value: 2.57e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSlyfkdliQRSVQDSSQSSREKLELvLSNLQADVLELLLE 390
Cdd:cd18218    1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGAS-------QQLGRQLTNPNPGQWCL-GEGISPSTFKQLLD 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Cdd:cd18218   73 FVYGESVEVQPGELRPLLEAARALEVESLEEAC 105

BTB_POZ_TDPOZ

cd18344

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

312-435

6.43e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349653 [Multi-domain] Cd Length: 128 Bit Score: 46.49 E-value: 6.43e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 312 PKEMLK-ELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREklelvLSNLQADVLELLLE 390
Cdd:cd18344    6 PRHMLTdDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIE-----IHDLDPQVFKEMMG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 256818756 391 FVYTGSL--VIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASN 435
Cdd:cd18344   81 FIYTGKAphLHSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127

BTB_POZ_RCBTB1_2

cd18298

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

325-429

6.86e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349607 [Multi-domain] Cd Length: 108 Bit Score: 45.71 E-value: 6.86e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 325 AKAF-----TDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdSSQSSREKLELVLSNLQADVLELLLEFVYTGSLVI 399
Cdd:cd18298    4 RKAFndprtSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQ-----SHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDL 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 256818756 400 DSANAKTLLEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18298   79 PPEDAIGLLDLANSYCEERLKKLCEDIIKQ 108

PLN02153

epithiospecifier protein

672-872

7.31e-06

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 49.21 E-value: 7.31e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 672 PRCRHNSLVYDGKIYTLGGLGVAGnvDHVER----YDTITNQWeAVAP----LPK-AVHSAAATVCGGKIYVFGGVNEAg 742
Cdd:PLN02153  22 PRCSHGIAVVGDKLYSFGGELKPN--EHIDKdlyvFDFNTHTW-SIAPangdVPRiSCLGVRMVAVGTKLYIFGGRDEK- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 743 RAAGVLQSYVPQTNTWSFIESpmIDNKYAP-AVTLNG------FVFILGGAyARATTIYDPEK------GNIKAG----- 804
Cdd:PLN02153  98 REFSDFYSYDTVKNEWTFLTK--LDEEGGPeARTFHSmasdenHVYVFGGV-SKGGLMKTPERfrtieaYNIADGkwvql 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 805 --PNMN-HSRQFCSAVVLDGKIYATGGIVSSEGPALGN------MEAYEPTTNTWTLLPHMPC-----PVFRHGcvVIKK 870
Cdd:PLN02153 175 pdPGENfEKRGGAGFAVVQGKIWVVYGFATSILPGGKSdyesnaVQFFDPASGKWTEVETTGAkpsarSVFAHA--VVGK 252


                 ..
gi 256818756 871 YI 872
Cdd:PLN02153 253 YI 254

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

313-416

8.18e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 45.28 E-value: 8.18e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 313 KEMLKELNQQrrakAFTDLKIVVEGRE-FEVHQNVLASCSLYFKDLIqrSVQdssqssrekLELVLSNL-QADVLELLLE 390
Cdd:cd18299    1 EDLRNLLHSP----SCADVVFILQGGVrIFAHRIVLAAASSVFADLF--LMM---------TVVTLDSDiTPEAFRRVLE 65

                         90       100
                 ....*....|....*....|....*.
gi 256818756 391 FVYTGSLVIDSANAKTLLEAASKFQF 416
Cdd:cd18299   66 FLYTGVLDENEDDLKELKDAAELLEL 91

BTB_POZ_KBTBD11

cd18275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

330-440

1.04e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349584 [Multi-domain] Cd Length: 104 Bit Score: 45.17 E-value: 1.04e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 330 DLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVqdssqssrekleLVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLE 409
Cdd:cd18275    6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDI------------LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVA 73

                         90       100       110
                 ....*....|....*....|....*....|.
gi 256818756 410 AASKFQFHTFCKVCVSFLEKQLTASNCLGVL 440
Cdd:cd18275   74 GARFLQMPCAAQCAVDAVRAQLCLGNCYEVL 104

Kelch

Kelch domain;

638-683

1.32e-05

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 42.93 E-value: 1.32e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 256818756   638 IYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDG 683
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_Rank-5

cd18303

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

326-436

1.59e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349612 [Multi-domain] Cd Length: 120 Bit Score: 45.01 E-value: 1.59e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 326 KAFTDLKIVVEGREFEVHQNVLAScslyfkdliqRSVQDSSQSSREKLELVLSNLQADVLELLLEFVYTGsLVIDSANAK 405
Cdd:cd18303   16 ELYSDITIKLADKSIPAHKFVLAA----------RSEKWSNENLASTNELDLSDISYEVVLALLRWLYTD-ELDLTLDDE 84

                         90       100       110
                 ....*....|....*....|....*....|....
gi 256818756 406 TLLE---AASKFQFHTFCKVCVSFLEKQLTASNC 436
Cdd:cd18303   85 FLLElmkAAKRFQLTDLVERCERALMSSVNVDNC 118

BTB_POZ_ZBTB6

cd18197

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

304-427

1.64e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349506 [Multi-domain] Cd Length: 116 Bit Score: 44.86 E-value: 1.64e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 304 YEFTDPGhpKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliqrsvQDSSQSSREKLELVLSNlqAD 383
Cdd:cd18197    3 FKFEQQG--DAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRD------QFLLNQSKQVRITILQS--AE 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 256818756 384 VLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
Cdd:cd18197   73 VGRKLLLSCYTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116

BACK_KLHL11

cd18451

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...

431-518

2.04e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Pssm-ID: 350526 [Multi-domain] Cd Length: 88 Bit Score: 43.80 E-value: 2.04e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPA 510
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 256818756 511 TRAQYAAE 518
Cdd:cd18451   81 ERERYFEE 88

BTB_POZ_BPM_plant

cd18280

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

329-414

2.27e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349589 [Multi-domain] Cd Length: 121 Bit Score: 44.63 E-value: 2.27e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 329 TDLKIVVEGREFEVHQNVLASCSLYFKDLIqrsvQDSSQSSREKlELVLSNLQADVLELLLEFVYTGSL----------- 397
Cdd:cd18280   15 ADVTFNVDGEKFRAHKLVLAARSPVFRSML----FGPMREENEG-EIVIEDVEPPVFKALLHFIYKDELpddvepagsds 89

                         90
                 ....*....|....*...
gi 256818756 398 -VIDSANAKTLLEAASKF 414
Cdd:cd18280   90 sSLDTTMAQHLLAAADRY 107

BTB_POZ_ZBTB25_ZNF46_KUP

cd18213

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

310-452

3.08e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349522 [Multi-domain] Cd Length: 128 Bit Score: 44.50 E-value: 3.08e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 310 GHPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRsvqdssQSSrEKLELVLSNLQADVLELLL 389
Cdd:cd18213    3 SHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIH------QSS-ECIKIQPTDIQPDIFSYLL 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256818756 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVcvsflekqltaSNCLGVLAMAEAMQCSELY 452
Cdd:cd18213   76 HIMYTGKGPKQSVDHSRLEEGIRFLHANYLSRI-----------ATEMNQDFSPETMQSSNLY 127

Kelch_6

Kelch motif;

672-719

4.13e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 41.55 E-value: 4.13e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 256818756  672 PRCRHNSLVYDGKIYTLGGLGVAGN-VDHVERYDTITNQWEAVAPLPKA 719
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPaLNKLEVYNPLTKSWEELPPLPTP 49

Kelch

Kelch domain;

684-730

4.34e-05

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 41.39 E-value: 4.34e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 256818756   684 KIYTLGGLGvaGNVDH--VERYDTITNQWEAVAPLPKAVHSAAATVCGG 730
Cdd:smart00612   1 KIYVVGGFD--GGQRLksVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

721-765

4.68e-05

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 41.44 E-value: 4.68e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 256818756  721 HSAAATVCGGKIYVFGGVNEAGRAAGVlQSYVPQTNTWSFIESPM 765
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQSLNSV-EVYDPETNTWSKLPSMP 46

PHA02713

hypothetical protein; Provisional

305-713

5.08e-05

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 46.93 E-value: 5.08e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 305 EFTDPGHPKEMLKELNQQRRAKAFTDLKIVV-EGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSSREKLELvlsnLQAD 383
Cdd:PHA02713   2 DIDDIKHNRRVVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNLQM----FDKD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 384 VLELLLEFVYTGSlvIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLamaeamqcSELYHMAKAFALQIF 463
Cdd:PHA02713  78 AVKNIVQYLYNRH--ISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMY--------HRLYEMSHIPIVKYI 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 464 PEVAAQEEILSISKDDFIAYVSN---DSLNTKAEELVYE------TVIKWIKKDPATRAQYAAeLLAAVRLPFIHPSYLL 534
Cdd:PHA02713 148 KRMLMSNIPTLITTDAFKKTVFEilfDIISTNDNVYLYRegykvtILLKWLEYNYITEEQLLC-ILSCIDIQNLDKKSRL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 535 NVVDNEELIKSSEACRDLVNEAKRYHMLPhaRQ-------------------------EMQTPRTRPR-----LSAGVAE 584
Cdd:PHA02713 227 LLYSNKTINMYPSCIQFLLDNKQNRNIIP--RQlclvchdtkynvcnpcilvynintmEYSVISTIPNhiinyASAIVDN 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 585 VIVLVGGRQMVgmtqrslvavtcwNPQNNKWYPL-------ASLP--FYDREFFSVVSAGDNIYLSGGMESGVTLADVWC 655
Cdd:PHA02713 305 EIIIAGGYNFN-------------NPSLNKVYKInienkihVELPpmIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIEC 371

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 256818756 656 YMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGG---------------LGVAGNV---DHVERYDTITNQWEAV 713
Cdd:PHA02713 372 YTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGrtehidytsvhhmnsIDMEEDThssNKVIRYDTVNNIWETL 447

PRK10263

DNA translocase FtsK; Provisional

66-247

5.80e-05

DNA translocase FtsK; Provisional

Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 47.00 E-value: 5.80e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   66 PATAPapcTTGSSEAITSLVVSSASA-ATTKAPGISKADNQSQGLTtsIRWGQTPVNQS-----TPWDTDEPPSKQMRES 139
Cdd:PRK10263  315 PITEP---VAVAAAATTATQSWAAPVePVTQTPPVASVDVPPAQPT--VAWQPVPGPQTgepviAPAPEGYPQQSQYAQP 389

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  140 DNPGTGPWVTTVAAgNQPSLITHSYGVTQPPTFSPAVN--VQAPVIGVTPSLPPHVGPQLPLIPGHYSLPQPPSQPLSSV 217
Cdd:PRK10263  390 AVQYNEPLQQPVQP-QQPYYAPAAEQPAQQPYYAPAPEqpAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTY 468

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 256818756  218 VVNMPAQALYASPQ----PLAVSTLPGVGQV--SRP 247
Cdd:PRK10263  469 QQPAAQEPLYQQPQpveqQPVVEPEPVVEETkpARP 504

BTB_POZ_ZBTB2

cd18193

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

315-414

5.94e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349502 [Multi-domain] Cd Length: 115 Bit Score: 43.06 E-value: 5.94e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRsvQDSsqssrEKLELVLSNLQADVLELLLEFVYT 394
Cdd:cd18193    8 LLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVH--QTS-----ECVRLKPTDIQPDIFSYLLHLMYT 80

                         90       100
                 ....*....|....*....|...
gi 256818756 395 GSL---VIDSANaktlLEAASKF 414
Cdd:cd18193   81 GKMapqLIDPVR----LEQGIKF 99

Atrophin-1

pfam03154

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...

94-287

1.04e-04

Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 46.30 E-value: 1.04e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   94 TKAPGI-SKADNQSQGLTTS---IRWGQTPVNQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPSLITHSYGVTQP 169
Cdd:pfam03154 143 STSPSIpSPQDNESDSDSSAqqqILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQ 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  170 PTFSPAVNVQA--------------PVIGVTPSLPP-HVGPQLPLIPGHYSLPQPPSQPLSSVVVNMPAQAlyaSPQPLA 234
Cdd:pfam03154 223 STAAPHTLIQQtptlhpqrlpsphpPLQPMTQPPPPsQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPV---PPQPFP 299

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256818756  235 VSTLPGVGQVSrPGPTPVGNGHMAGPLLPPPPPAQPSAALPS----------SVPATNGPPTT 287
Cdd:pfam03154 300 LTPQSSQSQVP-PGPSPAAPGQSQQRIHTPPSQSQLQSQQPPreqplppaplSMPHIKPPPTT 361

Kelch_4

pfam13418

Galactose oxidase, central domain;

811-858

1.24e-04

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 40.29 E-value: 1.24e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 256818756  811 RQFCSAVVL-DGKIYATGGIvSSEGPALGNMEAYEPTTNTWTLLPHMPC 858
Cdd:pfam13418   2 RAYHTSTSIpDDTIYLFGGE-GEDGTLLSDLWVFDLSTNEWTRLGSLPS 49

PHA03247

large tegument protein UL36; Provisional

34-295

1.56e-04

large tegument protein UL36; Provisional

Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.70 E-value: 1.56e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   34 SVTSGAGGSTASSLSARP-------GLLPLPVVPSRLPTPATAPAPCTTGSSEAITSLVVSSASAAttkaPGISKADNQS 106
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPrapvddrGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTV----PPPERPRDDP 2656

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  107 QGLTTSIRwgQTPVNQSTPWDTDEPPSKQMRESDNPGTGPwVTTVA----AGNQPSLITHSYGVTQPPTFSPAVNVQA-P 181
Cdd:PHA03247 2657 APGRVSRP--RRARRLGRAAQASSPPQRPRRRAARPTVGS-LTSLAdpppPPPTPEPAPHALVSATPLPPGPAAARQAsP 2733

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  182 VIGVTPSLPPH-VGPQLPLIPGHYSLPQPPSQPLSS----VVVNMPAQALYASPQPLAVSTLPGVGQVSRPGPTPVGNGH 256
Cdd:PHA03247 2734 ALPAAPAPPAVpAGPATPGGPARPARPPTTAGPPAPappaAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA 2813

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 256818756  257 MAGPLLPPPPPAQPSAALPSSVPATNGPPTTDSAHGLQM 295
Cdd:PHA03247 2814 PAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL 2852

Kelch_6

Kelch motif;

811-859

2.98e-04

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 39.24 E-value: 2.98e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 256818756  811 RQFCSAVVLDGKIYATGGIVSSeGPALGNMEAYEPTTNTWTLLPHMPCP 859
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNA-SPALNKLEVYNPLTKSWEELPPLPTP 49

BTB2_POZ_IBtk

cd18302

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

328-394

3.95e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349611 [Multi-domain] Cd Length: 113 Bit Score: 40.81 E-value: 3.95e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 256818756 328 FTDLKIV-VEGREFEVHQNVLASCSLYFKDLIQRSVQDSsqSSREKLELVLSnlqADVLELLLEFVYT 394
Cdd:cd18302    5 LYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSSWIEA--SSCSALTMPIP---SDILEIILDYLYT 67

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

329-401

4.50e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 40.71 E-value: 4.50e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256818756 329 TDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSSQSsreklELVLSNLQADVLELLLEFVYTGSLVIDS 401
Cdd:cd18286   18 SDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSS-----EITLTGVSHAAVSFVLLFIYGGVLDLPD 85

BACK_NS1BP_IVNS1ABP

cd18502

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...

431-507

6.10e-04

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

Pssm-ID: 350577 Cd Length: 99 Bit Score: 39.91 E-value: 6.10e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256818756 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSIS--KDDFIaYVSNDSLNTKAEELVYETVIKWIKK 507
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPrlQIEVI-LESNQELESINERKLCQLVLEWVQR 78

Kelch_6

Kelch motif;

721-767

7.68e-04

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 38.09 E-value: 7.68e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 256818756  721 HSAAAtvCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMID 767
Cdd:pfam13964   5 HSVVS--VGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTP 49

PLN02193

nitrile-specifier protein

631-788

8.27e-04

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 43.02 E-value: 8.27e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 631 VVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNL---VSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTIT 707
Cdd:PLN02193 224 MVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLltpVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVD 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 708 NQW-EAVAPLPK--AVHSAAATVCGGKIYVFGGVNeaGRAAGVLQSYVPQTNTWSFIES----PMIDNKYAPAVtLNGFV 780
Cdd:PLN02193 304 KKWfHCSTPGDSfsIRGGAGLEVVQGKVWVVYGFN--GCEVDDVHYYDPVQDKWTQVETfgvrPSERSVFASAA-VGKHI 380


                 ....*...
gi 256818756 781 FILGGAYA 788
Cdd:PLN02193 381 VIFGGEIA 388

Kelch_4

pfam13418

Galactose oxidase, central domain;

672-717

1.00e-03

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 37.59 E-value: 1.00e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 256818756  672 PRCRHnSLVY--DGKIYTLGGLGVAGNV-DHVERYDTITNQWEAVAPLP 717
Cdd:pfam13418   1 PRAYH-TSTSipDDTIYLFGGEGEDGTLlSDLWVFDLSTNEWTRLGSLP 48

Chi1

COG3469

Chitinase [Carbohydrate transport and metabolism];

21-193

1.05e-03

Chitinase [Carbohydrate transport and metabolism];

Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 42.43 E-value: 1.05e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  21 WSVNGTHGATSVCSVTSGAGGSTASSLSARPGLLPLPVVPSRLPTPATAPAPCTTGSSEAITSLVVSSASAATTKAPGIS 100
Cdd:COG3469   52 AASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 101 KADNQSQGLTTSIRWGQTPVNQSTPWDTDEPPSKQmrESDNPGTGPWVTTVAAGNQPSliTHSYGVTQPPTFSPAvnvqA 180
Cdd:COG3469  132 STTTSGASATSSAGSTTTTTTVSGTETATGGTTTT--STTTTTTSASTTPSATTTATA--TTASGATTPSATTTA----T 203

                        170
                 ....*....|...
gi 256818756 181 PVIGVTPSLPPHV 193
Cdd:COG3469  204 TTGPPTPGLPKHV 216

BTB_POZ_BTBD1_2

cd18281

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

343-435

1.39e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349590 [Multi-domain] Cd Length: 127 Bit Score: 39.73 E-value: 1.39e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 343 HQNVLASCSLYFKDLIQRSVQDSSQssreklELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
Cdd:cd18281   41 HKFVLSIGSAVFDAMFNGGMATTSA------EIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESA 114

                         90
                 ....*....|...
gi 256818756 423 CVSFLEKQLTASN 435
Cdd:cd18281  115 CVEFLKKNLSSDN 127

PLN02153

epithiospecifier protein

631-785

1.42e-03

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 41.90 E-value: 1.42e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 631 VVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTV---PRCR--HNSLVYDGKIYTLGGLGVAGNVDHVERYDT 705
Cdd:PLN02153  81 MVAVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEeggPEARtfHSMASDENHVYVFGGVSKGGLMKTPERFRT 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 706 IT------NQWeAVAPLP----KAVHSAAATVCGGKIYVFGGVNEAGRAAG-------VLQSYVPQTNTWSFIES----P 764
Cdd:PLN02153 161 IEayniadGKW-VQLPDPgenfEKRGGAGFAVVQGKIWVVYGFATSILPGGksdyesnAVQFFDPASGKWTEVETtgakP 239

                        170       180
                 ....*....|....*....|.
gi 256818756 765 MIDNKYAPAVtLNGFVFILGG 785
Cdd:PLN02153 240 SARSVFAHAV-VGKYIIIFGG 259

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

672-716

1.49e-03

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 37.32 E-value: 1.49e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 256818756  672 PRCRHNSLVYDGKIYTLGGLGVAGN--VDHVERYDTITNQWEAVAPL 716
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDlsSSDVLVYDPETNVWTEVPRL 47

BACK_calicin

cd18503

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...

435-506

2.12e-03

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.

Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 37.71 E-value: 2.12e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 256818756 435 NCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIK 506
Cdd:cd18503    5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTE 76

BACK_BTBD9

cd14822

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...

431-528

2.55e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

Pssm-ID: 350518 [Multi-domain] Cd Length: 101 Bit Score: 37.98 E-value: 2.55e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 431 LTASN-CLgVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLntKAEEL-VYETVIKWIKKD 508
Cdd:cd14822    1 LNIRNvCL-IYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSF--CAPEVdIFNAVRRWCEHN 77

                         90       100
                 ....*....|....*....|
gi 256818756 509 PaTRAQYAAELLAAVRLPFI 528
Cdd:cd14822   78 P-DSKEDAKEILEAVRLPLM 96

BTB1_POZ_BTBD7

cd18283

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

329-397

2.65e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349592 [Multi-domain] Cd Length: 92 Bit Score: 37.70 E-value: 2.65e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 256818756 329 TDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSvqdSSQSSREKLELVLSNLQADVLELLLEFVYTGSL 397
Cdd:cd18283    3 TDVDLVFQGTCFPVHRAILSARCPFFRDLLSSS---PGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEF 68

Kelch_3

pfam13415

Galactose oxidase, central domain;

682-727

2.67e-03

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 36.50 E-value: 2.67e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 256818756  682 DGKIYTLGGLGVAGN--VDHVERYDTITNQWEAVAPLPKAVHSAAATV 727
Cdd:pfam13415   1 GDKLYIFGGLGFDGQtrLNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48

BTB_POZ_ZBTB26_Bioref

cd18214

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

311-429

3.05e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349523 [Multi-domain] Cd Length: 122 Bit Score: 38.65 E-value: 3.05e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 311 HPKEMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDliQRSVQDSSqssreklELVLSNLQ-ADVLELLL 389
Cdd:cd18214    8 YGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRD--QFLLNDSR-------EVQISILQnSEVGRQLL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 256818756 390 EFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18214   79 LSCYTGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWK 118

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

572-654

3.73e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 40.14 E-value: 3.73e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 572 PRTRPRLSAGVAEVIVLVggrqmVGMTQRSLVAVTCWNPQNNKWYPLASLPFyDREFFSVVSAGDNIYLSGGM-ESGVTL 650
Cdd:COG3055  194 PTARAGHAAAVLGGKILV-----FGGESGFSDEVEAYDPATNTWTALGELPT-PRHGHAAVLTDGKVYVIGGEtKPGVRT 267


                 ....
gi 256818756 651 ADVW 654
Cdd:COG3055  268 PLVT 271

PHA03378

EBNA-3B; Provisional

47-251

4.26e-03

EBNA-3B; Provisional

Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 40.82 E-value: 4.26e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  47 LSARPGLLPLPVVPSRLPTPA--TAPAPCTTGSSEAITSLVVSSASAATTKAPGISKADNQSQGLTTSI-----RWGQTP 119
Cdd:PHA03378 563 LLPAPGLGPLQIQPLTSPTTSqlASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIpmrplRMQPIT 642

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 120 VNQSTPWDTDEPPSKQMresdNPGTGPWVTTVAAGNQPSLITHSygVTQPPTFSPAvNVQAPVIGVTPSLPPHVGPQLPL 199
Cdd:PHA03378 643 FNVLVFPTPHQPPQVEI----TPYKPTWTQIGHIPYQPSPTGAN--TMLPIQWAPG-TMQPPPRAPTPMRPPAAPPGRAQ 715

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 256818756 200 IPGHYSLPQPPSQ--------PLSSVVVNMPAQALYASPQPLAVSTLPGVGQVSRPG-PTP 251
Cdd:PHA03378 716 RPAAATGRARPPAaapgrarpPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGaPTP 776

DUF5585

pfam17823

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.

30-251

4.59e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.

Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 40.71 E-value: 4.59e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   30 TSVCSVTSGAGGSTASSLSARPGLLPLPVVPSRLPTPATAP-----------APCTTGSSEAITSLVVSSASAATTKAPG 98
Cdd:pfam17823  97 LSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALpseafsapraaACRANASAAPRAAIAAASAPHAASPAPR 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756   99 ISKADNQSQGLTTSIRWGQTPVNQSTPwDTDEPPSkqmresdnpgtgPWVTTVAAGNQPSLIThsyGVTQPPTFSPAV-N 177
Cdd:pfam17823 177 TAASSTTAASSTTAASSAPTTAASSAP-ATLTPAR------------GISTAATATGHPAAGT---ALAAVGNSSPAAgT 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  178 VQAPVIGVTP----SLPPHVGpQLPLIPGHYSLPQPPSQPLSSvVVNMPAQALYASPQP----------LAVST-LPGVG 242
Cdd:pfam17823 241 VTAAVGTVTPaalaTLAAAAG-TVASAAGTINMGDPHARRLSP-AKHMPSDTMARNPAApmgaqaqgpiIQVSTdQPVHN 318


                  ....*....
gi 256818756  243 QVSRPGPTP 251
Cdd:pfam17823 319 TAGEPTPSP 327

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

626-670

7.46e-03

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 35.28 E-value: 7.46e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 256818756  626 REFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

Kelch_6

Kelch motif;

626-673

8.85e-03

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 35.00 E-value: 8.85e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 256818756  626 REFFSVVSAGDNIYLSGG-MESGVTLADVWCYmSLLDN-WNLVSRMTVPR 673
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVY-NPLTKsWEELPPLPTPR 50

BTB_POZ_RCBTB1_CLLD7

cd18353

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

329-429

8.91e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349662 [Multi-domain] Cd Length: 117 Bit Score: 37.24 E-value: 8.91e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 329 TDLKIVVEGREFEVHQNVLASCSLYFKDLIQrsvqdSSQSSREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLL 408
Cdd:cd18353   21 SDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQ-----SHWNEDMKEVIEIDQFSYPVYRAFLEYLYTDSVDLPPEDAIGLL 95

                         90       100
                 ....*....|....*....|.
gi 256818756 409 EAASKFQFHTFCKVCVSFLEK 429
Cdd:cd18353   96 DLATSYCENRLKKLCQHIIKR 116

PRK12323

DNA polymerase III subunit gamma/tau;

38-255

9.14e-03

DNA polymerase III subunit gamma/tau;

Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 39.86 E-value: 9.14e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756  38 GAGGSTASSLSARPGLLPLPVV---PSRLPTPATAPAPCTTGSSEAITSLVVSSASAATTKAPGISKADNQSQGLTTSIR 114
Cdd:PRK12323 368 SGGGAGPATAAAAPVAQPAPAAaapAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGA 447

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256818756 115 WGQTPVNQSTPWDTDEPPSKQMRESDNPGTG-PWVTTVAAGNQPSLITHSYGVTQPPTFspavnvqaPVIGVTPSLPPHV 193
Cdd:PRK12323 448 PAPAPAPAAAPAAAARPAAAGPRPVAAAAAAaPARAAPAAAPAPADDDPPPWEELPPEF--------ASPAPAQPDAAPA 519

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256818756 194 GPQLPLIPGH-YSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPgvgQVSRPGPTPVGNG 255
Cdd:PRK12323 520 GWVAESIPDPaTADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPP---RASASGLPDMFDG 579

Kelch