NCBI Conserved Domain Search

Conserved domains on [gi|242397478|ref|NP_001156412|]

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olfactory receptor 715-like [Mus musculus]

Protein Classification

olfactory receptor( domain architecture ID 11607024)

olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 10, subfamily A olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

26-299

5.89e-148

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 416.86 E-value: 5.89e-148

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15225    2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15225   82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15225  162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 266 K--EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15225  242 YspETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

Name

Accession

Description

Interval

E-value

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

26-299

5.89e-148

Pssm-ID: 320353 Cd Length: 277 Bit Score: 416.86 E-value: 5.89e-148

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15225    2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15225   82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15225  162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 266 K--EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15225  242 YspETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-302

1.65e-47

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 160.74 E-value: 1.65e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478   31 FLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGCT 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  111 QCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALAST 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  191 DTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKEQEK 270
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 242397478  271 LVSVF----YAMVTPMLNPLIYSLRNKDVKGALWKV 302
Cdd:pfam13853 241 LLQIMmanaYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

27-237

4.12e-03

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 38.61 E-value: 4.12e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNlFLMFLVRADSRLHTPMYFFLCNLSLADLCFsTNIVPQALIHllSRKKTISFRRCAAQLLLFLI 106
Cdd:PHA03087  43 LIVVYSTIFFFGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDLLF-VMTLPFQIYY--YILFQWSFGEFACKIVSGLY 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALL--AVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWtsgiLVSVVDTtFTLRLPYRGSNSIAHFFCeapal 184
Cdd:PHA03087 119 YIGFYNSMNfiTVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIW----IISIIET-TPILFVYTTKKDHETLIC----- 188

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 242397478 185 LALASTDTQTSEMAI-FLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKA 237
Cdd:PHA03087 189 CMFYNNKTMNWKLFInFEINIIGMLIPLTILLYCYSKILITLKGINKSKKNKKA 242

Name

Accession

Description

Interval

E-value

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

26-299

5.89e-148

Pssm-ID: 320353 Cd Length: 277 Bit Score: 416.86 E-value: 5.89e-148

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15225    2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15225   82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15225  162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 266 K--EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15225  242 YspETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

26-299

7.34e-145

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 408.79 E-value: 7.34e-145

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15428    2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15428   82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS- 264
Cdd:cd15428  162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSs 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 265 -SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15428  242 tSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

25-292

2.37e-139

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 394.72 E-value: 2.37e-139

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15237    1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPAL 184
Cdd:cd15237   81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 LALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS 264
Cdd:cd15237  161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 242397478 265 --SKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15237  241 thSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-292

1.90e-137

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 389.92 E-value: 1.90e-137

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd13954    2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd13954   82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS- 264
Cdd:cd13954  162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSs 241

                        250       260
                 ....*....|....*....|....*....
gi 242397478 265 -SKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd13954  242 ySSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

26-292

8.88e-132

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 375.31 E-value: 8.88e-132

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15230    2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15230   82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15230  162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                        250       260
                 ....*....|....*....|....*....
gi 242397478 266 K--EQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15230  242 YslDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-299

1.85e-128

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 367.26 E-value: 1.85e-128

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15421    2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15421   82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15421  162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 266 K--EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15421  242 HspEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

12-296

4.85e-125

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 358.94 E-value: 4.85e-125

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  12 FILLGLSDDPHTQKLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKT 91
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  92 ISFRRCAAQLLLFLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGS 171
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 172 NSIAHFFCEAPALLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILF 251
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 242397478 252 YGSGIITYMTPKS--SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVK 296
Cdd:cd15408  241 YGSLAFMYLRPSSrySLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

26-292

6.65e-125

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 358.07 E-value: 6.65e-125

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15431    2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDtTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15431   82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIP-VLTMPLHFCGPNVINHFFCEVQALL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTP--K 263
Cdd:cd15431  161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPqsK 240

                        250       260
                 ....*....|....*....|....*....
gi 242397478 264 SSKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15431  241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

27-299

1.11e-122

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 352.86 E-value: 1.11e-122

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15429    3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLA 186
Cdd:cd15429   83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS-- 264
Cdd:cd15429  163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSgs 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 242397478 265 SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15429  243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

27-299

1.17e-122

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 352.78 E-value: 1.17e-122

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15411    3 LFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLA 186
Cdd:cd15411   83 LATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS-- 264
Cdd:cd15411  163 LSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSsy 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 242397478 265 SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15411  243 SLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNAL 277

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

26-299

1.29e-122

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 352.72 E-value: 1.29e-122

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15231    2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15231   82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS- 264
Cdd:cd15231  162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSg 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 265 -SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15231  242 ySLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

26-292

4.60e-122

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 351.02 E-value: 4.60e-122

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15911    2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15911   82 SLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS- 264
Cdd:cd15911  162 KLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTn 241

                        250       260
                 ....*....|....*....|....*....
gi 242397478 265 -SKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15911  242 tSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

24-299

5.00e-122

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 351.14 E-value: 5.00e-122

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  24 QKLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLL 103
Cdd:cd15235    1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 104 FLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPA 183
Cdd:cd15235   81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 184 LLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPK 263
Cdd:cd15235  161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 242397478 264 SSK--EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15235  241 SSYsaDKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

11-302

1.20e-120

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 348.20 E-value: 1.20e-120

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  11 EFILLGLSDDPHTQKLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKK 90
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  91 TISFRRCAAQLLLFLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRG 170
Cdd:cd15943   81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 171 SNSIAHFFCEAPALLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVIL 250
Cdd:cd15943  161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 242397478 251 FYGSGIITYMTPKSS--KEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWKV 302
Cdd:cd15943  241 FYGTTLFMYLRPSSSysLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

26-299

1.21e-120

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 347.66 E-value: 1.21e-120

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15229    2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15229   82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTP--K 263
Cdd:cd15229  162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPnsA 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 264 SSKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15229  242 SSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

27-292

1.92e-120

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 346.92 E-value: 1.92e-120

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15947    3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLA 186
Cdd:cd15947   83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS-- 264
Cdd:cd15947  163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSsy 242

                        250       260
                 ....*....|....*....|....*...
gi 242397478 265 SKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15947  243 SQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

12-302

2.13e-120

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 347.72 E-value: 2.13e-120

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  12 FILLGLSDDPHTQKLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKT 91
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  92 ISFRRCAAQLLLFLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGS 171
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 172 NSIAHFFCEAPALLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILF 251
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 242397478 252 YGSGIITYMTPKS--SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWKV 302
Cdd:cd15410  241 HGTILFMYCRPSSsySLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

26-301

3.65e-120

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 346.60 E-value: 3.65e-120

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15419    2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15419   82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPK-- 263
Cdd:cd15419  162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGav 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 242397478 264 SSKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWK 301
Cdd:cd15419  242 SSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

26-299

6.36e-119

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 343.16 E-value: 6.36e-119

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15420    2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15420   82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15420  162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 266 K--EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15420  242 NsaEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-301

4.29e-118

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 341.16 E-value: 4.29e-118

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15417    2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15417   82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS- 264
Cdd:cd15417  162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSs 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 242397478 265 -SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWK 301
Cdd:cd15417  242 hSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

26-292

5.93e-118

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 340.62 E-value: 5.93e-118

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15912    2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15912   82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPK-- 263
Cdd:cd15912  162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSqs 241

                        250       260
                 ....*....|....*....|....*....
gi 242397478 264 SSKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15912  242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

26-292

1.47e-117

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 339.43 E-value: 1.47e-117

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15227    2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15227   82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS- 264
Cdd:cd15227  162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSd 241

                        250       260
                 ....*....|....*....|....*....
gi 242397478 265 -SKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15227  242 sPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

25-299

4.24e-113

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 328.57 E-value: 4.24e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15434    1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPAL 184
Cdd:cd15434   81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 LALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPK- 263
Cdd:cd15434  161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKn 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 242397478 264 -SSKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15434  241 sVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

26-299

4.99e-113

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 328.23 E-value: 4.99e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15424    2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15424   82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS- 264
Cdd:cd15424  162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSg 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 265 -SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15424  242 sTPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

25-292

6.00e-112

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 325.34 E-value: 6.00e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15918    1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPAL 184
Cdd:cd15918   81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 LALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS 264
Cdd:cd15918  161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 242397478 265 --SKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15918  241 shSASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

25-301

2.00e-111

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 324.35 E-value: 2.00e-111

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15412    1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPAL 184
Cdd:cd15412   81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 LALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS 264
Cdd:cd15412  161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 242397478 265 SK--EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWK 301
Cdd:cd15412  241 EEsvEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

25-299

1.47e-110

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 322.12 E-value: 1.47e-110

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15432    1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPAL 184
Cdd:cd15432   81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 LALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS 264
Cdd:cd15432  161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 242397478 265 --SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15432  241 nsSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

12-301

5.02e-110

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 321.31 E-value: 5.02e-110

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  12 FILLGLSDDPHTQKLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKT 91
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  92 ISFRRCAAQLLLFLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGS 171
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 172 NSIAHFFCEAPALLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILF 251
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 242397478 252 YGSGIITYMTPKS--SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWK 301
Cdd:cd15945  241 YGTLLFMYLRPSSsySLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

12-302

6.14e-109

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 318.65 E-value: 6.14e-109

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  12 FILLGLSDDPHTQKLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKT 91
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  92 ISFRRCAAQLLLFLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGS 171
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 172 NSIAHFFCEAPALLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILF 251
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 242397478 252 YGSGIITYMTPKS--SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWKV 302
Cdd:cd15944  241 YGTVIFMYLRPTSvySLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

27-301

1.11e-107

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 314.65 E-value: 1.11e-107

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15413    3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLA 186
Cdd:cd15413   83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSK 266
Cdd:cd15413  163 LSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSH 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 242397478 267 --EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWK 301
Cdd:cd15413  243 slDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

26-301

3.88e-106

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 310.88 E-value: 3.88e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15409    2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15409   82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15409  162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 242397478 266 K--EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWK 301
Cdd:cd15409  242 YalDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

27-299

3.43e-105

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 308.53 E-value: 3.43e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15416    3 LFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLA 186
Cdd:cd15416   83 FGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS-- 264
Cdd:cd15416  163 LSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSsy 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 242397478 265 SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15416  243 SMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGAL 277

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

16-302

9.96e-105

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 307.76 E-value: 9.96e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  16 GLSDDPHTQKLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFR 95
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  96 RCAAQLLLFLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIA 175
Cdd:cd15406   81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 176 HFFCEAPALLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSG 255
Cdd:cd15406  161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 242397478 256 IITYMTPKSSK--EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWKV 302
Cdd:cd15406  241 IFMYLKPSSSSsmTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

25-292

2.24e-104

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 306.22 E-value: 2.24e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15430    1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPAL 184
Cdd:cd15430   81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 LALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS 264
Cdd:cd15430  161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 242397478 265 SKEQ--EKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15430  241 KNAQisDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

26-292

5.69e-104

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 304.98 E-value: 5.69e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15224    2 LLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15224   82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPK-- 263
Cdd:cd15224  162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKai 241

                        250       260
                 ....*....|....*....|....*....
gi 242397478 264 SSKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15224  242 SSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

26-299

2.78e-103

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 303.34 E-value: 2.78e-103

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15234    2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15234   82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15234  162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 266 KEQEK--LVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15234  242 HSSRKtaVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

26-292

5.59e-102

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 299.78 E-value: 5.59e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15946    2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15946   82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS- 264
Cdd:cd15946  162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSn 241

                        250       260
                 ....*....|....*....|....*....
gi 242397478 265 -SKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15946  242 ySPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

27-301

1.17e-100

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 297.02 E-value: 1.17e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15415    3 LFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLA 186
Cdd:cd15415   83 FVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS-- 264
Cdd:cd15415  163 LSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSqy 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 242397478 265 SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWK 301
Cdd:cd15415  243 SLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

27-301

2.61e-100

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 295.87 E-value: 2.61e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15407    3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLA 186
Cdd:cd15407   83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS-- 264
Cdd:cd15407  163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSsh 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 242397478 265 SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWK 301
Cdd:cd15407  243 SMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-292

1.11e-98

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 291.47 E-value: 1.11e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15232    2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15232   82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS- 264
Cdd:cd15232  162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSs 241

                        250       260
                 ....*....|....*....|....*....
gi 242397478 265 -SKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15232  242 ySPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-305

4.76e-97

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 287.79 E-value: 4.76e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15414    2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15414   82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS- 264
Cdd:cd15414  162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSs 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 242397478 265 -SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL-WKVATK 305
Cdd:cd15414  242 sSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALrRTIRRK 284

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

25-299

4.01e-95

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 282.84 E-value: 4.01e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15433    1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPAL 184
Cdd:cd15433   81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 LALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS 264
Cdd:cd15433  161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 242397478 265 SKEQE--KLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15433  241 RYSQAhgKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

26-299

4.39e-95

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 282.80 E-value: 4.39e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRK-KTISFRRCAAQLLLF 104
Cdd:cd15916    2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPAL 184
Cdd:cd15916   82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 LALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS 264
Cdd:cd15916  162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 242397478 265 SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15916  242 KEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

25-292

3.82e-94

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 279.87 E-value: 3.82e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15939    1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPAL 184
Cdd:cd15939   81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 LALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTvVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS 264
Cdd:cd15939  161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVT 239

                        250       260
                 ....*....|....*....|....*...
gi 242397478 265 SKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15939  240 TFPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-292

3.10e-92

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 274.85 E-value: 3.10e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15226    2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15226   82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKmKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15226  162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFST 240

                        250       260
                 ....*....|....*....|....*..
gi 242397478 266 KEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15226  241 FPVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

26-299

4.29e-92

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 275.08 E-value: 4.29e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15228    2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15228   82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15228  162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 242397478 266 KEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15228  242 PVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

27-292

1.13e-91

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 273.80 E-value: 1.13e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15915    3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLA 186
Cdd:cd15915   83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKM-KSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTP--K 263
Cdd:cd15915  163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPssG 242

                        250       260
                 ....*....|....*....|....*....
gi 242397478 264 SSKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15915  243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

26-299

6.47e-91

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 272.03 E-value: 6.47e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15236    2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15236   82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15236  162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 266 KEQEK--LVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15236  242 NSSDKdiVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

27-299

1.04e-90

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 271.60 E-value: 1.04e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15405    3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLA 186
Cdd:cd15405   83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS-- 264
Cdd:cd15405  163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSvg 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 242397478 265 SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15405  243 SVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

26-292

4.83e-90

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 269.63 E-value: 4.83e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15914    2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15914   82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15914  162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                        250       260
                 ....*....|....*....|....*....
gi 242397478 266 KE--QEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15914  242 YSldYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

26-292

3.76e-89

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 267.38 E-value: 3.76e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15940    2 AFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15940   82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMkSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15940  162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTS 240

                        250       260
                 ....*....|....*....|....*..
gi 242397478 266 KEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15940  241 FSEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

26-292

1.00e-88

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 266.10 E-value: 1.00e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15913    2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15913   82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTP--K 263
Cdd:cd15913  162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPgsG 241

                        250       260
                 ....*....|....*....|....*....
gi 242397478 264 SSKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15913  242 NSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

24-302

5.89e-88

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 264.72 E-value: 5.89e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  24 QKLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLL 103
Cdd:cd15418    1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 104 FLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPA 183
Cdd:cd15418   81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 184 LLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPK 263
Cdd:cd15418  161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 242397478 264 SSK--EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGALWKV 302
Cdd:cd15418  241 SSHtpDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

26-299

7.18e-85

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 256.64 E-value: 7.18e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15233    2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15233   82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS- 264
Cdd:cd15233  162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSv 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 265 -SKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15233  242 ySSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

27-299

1.76e-83

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 253.12 E-value: 1.76e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15942    3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLA 186
Cdd:cd15942   83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSK 266
Cdd:cd15942  163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 242397478 267 EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15942  243 PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

26-299

1.08e-82

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 251.31 E-value: 1.08e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHT-PMYFFLCNLSLADLCFSTNIVPQALIHLLSRK-KTISFRRCAAQLLL 103
Cdd:cd15941    2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 104 FLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPA 183
Cdd:cd15941   82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 184 LLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPK 263
Cdd:cd15941  162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 264 SSKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15941  242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-292

1.12e-80

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 245.71 E-value: 1.12e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15936    2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15936   82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGhIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15936  162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYT-VILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQT 240

                        250       260
                 ....*....|....*....|....*..
gi 242397478 266 KEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15936  241 FPMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-292

1.04e-73

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 227.83 E-value: 1.04e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15938    2 LLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15938   82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVvkmKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15938  162 KLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTI---RSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFST 238

                        250       260
                 ....*....|....*....|....*..
gi 242397478 266 KEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15938  239 FPVDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

26-292

5.86e-71

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 220.79 E-value: 5.86e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRL-HTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15935    2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPAL 184
Cdd:cd15935   82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 LALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGhIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKS 264
Cdd:cd15935  162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYG-IILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS 240

                        250       260
                 ....*....|....*....|....*...
gi 242397478 265 SKEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15935  241 SSSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

26-292

5.12e-66

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 208.05 E-value: 5.12e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15937    2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15937   82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTvVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15937  162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRS 240

                        250       260
                 ....*....|....*....|....*..
gi 242397478 266 KEQEKLVSVFYAMVTPMLNPLIYSLRN 292
Cdd:cd15937  241 FPMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

26-299

1.34e-62

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 199.83 E-value: 1.34e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15223    2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15223   82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 186 ALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSS 265
Cdd:cd15223  162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 242397478 266 K----EQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15223  242 KtippDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

29-293

4.15e-59

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 190.58 E-value: 4.15e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15917    5 IPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALA 188
Cdd:cd15917   85 AMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 189 STDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKEQ 268
Cdd:cd15917  165 CGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHV 244

                        250       260
                 ....*....|....*....|....*....
gi 242397478 269 EK----LVSVFYAMVTPMLNPLIYSLRNK 293
Cdd:cd15917  245 PPhvhiLLANLYLLLPPMLNPIVYGVRTK 273

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

29-295

7.52e-58

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 187.62 E-value: 7.52e-58

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15950    5 IPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALA 188
Cdd:cd15950   85 AVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 189 STDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKE- 267
Cdd:cd15950  165 CADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRFGQGv 244

                        250       260       270
                 ....*....|....*....|....*....|.
gi 242397478 268 ---QEKLVSVFYAMVTPMLNPLIYSLRNKDV 295
Cdd:cd15950  245 pphTQVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

29-293

1.74e-57

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 186.34 E-value: 1.74e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15221    5 IPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALA 188
Cdd:cd15221   85 VTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 189 STDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKEQ 268
Cdd:cd15221  165 CADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGRHI 244

                        250       260
                 ....*....|....*....|....*....
gi 242397478 269 EKLVSVF----YAMVTPMLNPLIYSLRNK 293
Cdd:cd15221  245 PRHVHILlanlYVLVPPMLNPIVYGVKTK 273

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

29-295

1.27e-56

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 184.12 E-value: 1.27e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15952    5 FPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALA 188
Cdd:cd15952   85 GMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 189 STDTQTSemAIFLMGVV-ILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKE 267
Cdd:cd15952  165 CASIRIN--IIYGLFAIsVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHN 242

                        250       260       270
                 ....*....|....*....|....*....|..
gi 242397478 268 QEK----LVSVFYAMVTPMLNPLIYSLRNKDV 295
Cdd:cd15952  243 IPRyihiLLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

29-295

1.44e-55

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 181.39 E-value: 1.44e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15951    5 IPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALA 188
Cdd:cd15951   85 TMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 189 STDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKEQ 268
Cdd:cd15951  165 CADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNV 244

                        250       260       270
                 ....*....|....*....|....*....|.
gi 242397478 269 EKLVSVF----YAMVTPMLNPLIYSLRNKDV 295
Cdd:cd15951  245 PPHVHILianvYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

29-293

1.75e-53

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 176.30 E-value: 1.75e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15953    5 IPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALA 188
Cdd:cd15953   85 IMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 189 STDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKEQ 268
Cdd:cd15953  165 CGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFGQGI 244

                        250       260
                 ....*....|....*....|....*....
gi 242397478 269 EK----LVSVFYAMVTPMLNPLIYSLRNK 293
Cdd:cd15953  245 APhihiILANLYLLVPPMLNPIIYGVKTK 273

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

27-293

3.38e-51

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 170.37 E-value: 3.38e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15222    3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLA 186
Cdd:cd15222   83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LASTDTQTSemaIFLMGVVILL---IPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPK 263
Cdd:cd15222  163 LACSDTRVN---SIYGLFVVLStmgLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHR 239

                        250       260       270
                 ....*....|....*....|....*....|....
gi 242397478 264 SSKEQEKLVSVF----YAMVTPMLNPLIYSLRNK 293
Cdd:cd15222  240 FGKHASPLVHVLmanvYLLVPPVLNPIIYSVKTK 273

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-302

1.65e-47

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 160.74 E-value: 1.65e-47

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478   31 FLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGCT 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  111 QCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALAST 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  191 DTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKEQEK 270
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 242397478  271 LVSVF----YAMVTPMLNPLIYSLRNKDVKGALWKV 302
Cdd:pfam13853 241 LLQIMmanaYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

29-296

2.31e-47

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 160.46 E-value: 2.31e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15948    6 IPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALA 188
Cdd:cd15948   86 IMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 189 STDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKEQ 268
Cdd:cd15948  166 CGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHRFARHV 245

                        250       260       270
                 ....*....|....*....|....*....|..
gi 242397478 269 EK----LVSVFYAMVTPMLNPLIYSLRNKDVK 296
Cdd:cd15948  246 APhvhiLLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

10-296

3.31e-46

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 158.02 E-value: 3.31e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  10 TEFILLGLSDDPHTQKLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRK 89
Cdd:cd15949    2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  90 KTISFRRCAAQLLLFLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYR 169
Cdd:cd15949   82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 170 GSNSIAHFFCEAPALLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVI 249
Cdd:cd15949  162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 242397478 250 LFY----GSGIITYMTPKSSKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVK 296
Cdd:cd15949  242 AFYvpiaVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

27-295

4.29e-44

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 151.94 E-value: 4.29e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15956    3 LSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLA 186
Cdd:cd15956   83 FSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMT----P 262
Cdd:cd15956  163 LACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMhrfgH 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 242397478 263 KSSKEQEKLVSVFYAMVTPMLNPLIYSLRNKDV 295
Cdd:cd15956  243 SVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

41-288

9.93e-41

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 142.44 E-value: 9.93e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478   41 GNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALI-HLLSRKKTISFRRCAAQLLLFLIFGCTQCALLAVMS 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVyYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  120 YDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNsiaHFFCeapalLALASTDTQTSEMAI 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVC-----FIDFPEDLSKPVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  200 FLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRF-------KAFSTCGSHLMVVILFYGSGIITYM------TPKSSK 266
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILCWLPYHIVNLldslalDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 242397478  267 EQEKLVSV--FYAMVTPMLNPLIY 288
Cdd:pfam00001 233 LLDKALSVtlWLAYVNSCLNPIIY 256

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

29-295

4.51e-40

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 141.44 E-value: 4.51e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15955    5 IPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLAT-VSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLAL 187
Cdd:cd15955   85 AFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVlVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 188 ASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKE 267
Cdd:cd15955  165 AADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHH 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 242397478 268 QEK----LVSVFYAMVTPMLNPLIYSLRNKDV 295
Cdd:cd15955  245 VAPyvhiLLSNLYLLVPPVLNPIVYGVKTKQI 276

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

29-295

1.91e-39

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 139.96 E-value: 1.91e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15954    5 IPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALA 188
Cdd:cd15954   85 GMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 189 STDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKEQ 268
Cdd:cd15954  165 CANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFGGHH 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 242397478 269 -----EKLVSVFYAMVTPMLNPLIYSLRNKDV 295
Cdd:cd15954  245 itphiHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

27-292

2.81e-24

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 99.29 E-value: 2.81e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCeapalla 186
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWP------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 lastDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAG--------------RFKAFSTCGSHLMVVILFY 252
Cdd:cd00637  154 ----DLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRssssnssrrrrrrrERKVTKTLLIVVVVFLLCW 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 242397478 253 GSGIITYMTPKSSKEQEKLVSVFY------AMVTPMLNPLIYSLRN 292
Cdd:cd00637  230 LPYFILLLLDVFGPDPSPLPRILYflalllAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

27-299

1.30e-20

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 89.16 E-value: 1.30e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMV-TVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd14967    1 LLAVFLSLIILvTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMT-WRVCIQLATVsWTSGILVSVvdTTFTLRLPYRGSNSIAHFFCeapal 184
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTkKRALIMIAAV-WVYSLLISL--PPLVGWRDETQPSVVDCECE----- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 lalastDTQTSEMAIFLMgVVILLIPVSLILVSYGHIIVTVVKmksaagRFKAFSTcgshLMVVIL--------FYGSGI 256
Cdd:cd14967  153 ------FTPNKIYVLVSS-VISFFIPLLIMIVLYARIFRVARR------ELKAAKT----LAIIVGafllcwlpFFIIYL 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 242397478 257 ITYMTPKSSKEQEkLVSVFY--AMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd14967  216 VSAFCPPDCVPPI-LYAVFFwlGYLNSALNPIIYALFNRDFRRAF 259

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

29-299

1.36e-15

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 75.41 E-value: 1.36e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd14972    3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVmSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVvdttftlrLPYRGSNSIahfFCEAPALLALA 188
Cdd:cd14972   83 ASAYSLLAI-AVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLGWNCV---LCDQESCSPLG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 189 STDTqtseMAIFLMGVVILLIPVSLILVSYGHIIVTVVK--------MKSAAGRFKAFSTCGSHLMVVILF-----YGSG 255
Cdd:cd14972  151 PGLP----KSYLVLILVFFFIALVIIVFLYVRIFWCLWRhanaiaarQEAAVPAQPSTSRKLAKTVVIVLGvflvcWLPL 226

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 242397478 256 IITYMTPKSSKEQEKLVSVFYAMVTPML-----NPLIYSLRNKDVKGAL 299
Cdd:cd14972  227 LILLVLDVLCPSVCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRAV 275

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

26-299

1.97e-15

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 74.94 E-value: 1.97e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGiymvtVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd14969    7 LSLIGVLG-----VVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLhYSSTMTWRVCIQLATVSWTSGILVSVvdttftlrLPYRGSNSIAHFF----Cea 181
Cdd:cd14969   82 FLGLVSISTLAALAFERYLVIVRPL-KAFRLSKRRALILIAFIWLYGLFWAL--------PPLFGWSSYVPEGggtsC-- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 182 pallALASTDTQTSEMA-IFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHL--------MVVILfy 252
Cdd:cd14969  151 ----SVDWYSKDPNSLSyIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKkaekkvakMVLVM-- 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242397478 253 gsgIITYM---TP------KSSKEQEKLVSVFYAMVTPML-------NPLIYSLRNKDVKGAL 299
Cdd:cd14969  225 ---IVAFLiawTPyavvslYVSFGGESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

26-298

4.35e-14

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 70.85 E-value: 4.35e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15067    1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWLFGRDWCDVWHSFD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSvvdttFTLRLPYRGSNSIahffcEAPAL 184
Cdd:cd15067   81 VLASTASILnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALIS-----FPAIAWWRAVDPG-----PSPPN 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 LALASTDTqtseMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAgrfkafSTCGSHLMVVIL----FYGSGIITYM 260
Cdd:cd15067  151 QCLFTDDS----GYLIFSSCVSFYIPLVVMLFTYYRIYRAAAKEQKAA------KTLGIVMGVFILcwlpFFVTNILIGF 220

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 242397478 261 TPKSSKEQEKLVSVFYA---MVTPMLNPLIYSLRNKDVKGA 298
Cdd:cd15067  221 CPSNCVSNPDILFPLVTwlgYINSGMNPIIYACSSRDFRRA 261

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

28-299

1.81e-12

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 66.51 E-value: 1.81e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  28 FILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALihLLSRKKTISFRRCAAQLLLFLIF 107
Cdd:cd14968    4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAI--LISLGLPTNFHGCLFMACLVLVL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 108 gcTQC---ALLAVmSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVV-----DTTFTLRLPYRGSNSIAHFfc 179
Cdd:cd14968   82 --TQSsifSLLAI-AIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTpmfgwNNGAPLESGCGEGGIQCLF-- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 180 eapallalasTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVK---------MKSAAGRF--KAFSTCGSHLMVV 248
Cdd:cd14968  157 ----------EEVIPMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKqlrqiesllRSRRSRSTlqKEVKAAKSLAIIL 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242397478 249 ILFYGSGI-------ITYMTPksskEQEKLVSVFYAMV-----TPMLNPLIYSLRNKDVKGAL 299
Cdd:cd14968  227 FLFALCWLplhiincITLFCP----ECKVPKILTYIAIllshaNSAVNPIVYAYRIRKFRQTF 285

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

30-298

2.89e-11

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 62.83 E-value: 2.89e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLG-IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15050    5 IALStISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVAS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWtsgiLVSvvdttFTLRLPYRGSNsiaHFFCEAPALLALA 188
Cdd:cd15050   85 TASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAW----LLS-----FLWVIPILGWH---HFARGGERVVLED 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 189 STDTQTSEMAIF--LMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRF----KAFSTCgsHLMVVILFygsgIITYMTP 262
Cdd:cd15050  153 KCETDFHDVTWFkvLTAILNFYIPSLLMLWFYAKIFKAVNRERKAAKQLgfimAAFILC--WIPYFILF----MVIAFCK 226

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 263 KSSKEQEKLVSVFYAMVTPMLNPLIYSLRNKDVKGA 298
Cdd:cd15050  227 NCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKT 262

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

29-299

6.90e-11

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 61.85 E-value: 6.90e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLL-SRKKTISFRRCAAQLLLFLIF 107
Cdd:cd15305    5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILyDYAWPLPRYLCPIWISLDVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 108 GCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVvdttftlRLPYRGSNSIAHFFCEAPALLal 187
Cdd:cd15305   85 STASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISM-------PIPVIGLQDDEKVFVNGTCVL-- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 188 astdtqTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVIL----FYGSGIITYMTPK 263
Cdd:cd15305  156 ------NDENFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLImwcpFFITNILSVLCKE 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 242397478 264 SSKEQ--EKLVSVFY--AMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15305  230 ACDQKlmEELLNVFVwvGYVSSGINPLVYTLFNKTYRRAF 269

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

34-156

3.43e-10

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 60.16 E-value: 3.43e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPqALIHLLSRKKTISFRRCAAQLLLFL-IFGCTQC 112
Cdd:cd15005   10 ILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFP-FVMASVRHGSGWIYGALSCKVIAFLaVLFCFHS 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 242397478 113 A-LLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15005   89 AfTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMA 133

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

26-236

3.50e-10

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 59.77 E-value: 3.50e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15012    1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIahfFCEAPALL 185
Cdd:cd15012   81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDG---QEEEICVL 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 242397478 186 ALASTDTQTSEMAIFlmgVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFK 236
Cdd:cd15012  158 DREMFNSKLYDTINF---IVWYLIPLLIMTVLYSKISIVLWKSSSIEARRK 205

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

26-293

5.29e-10

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 59.15 E-value: 5.29e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd14993    2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS----VVDTTFTLRLPYRGsnSIAHFFCea 181
Cdd:cd14993   82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMlpllVVYELEEIISSEPG--TITIYIC-- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 182 pallalasTDTQTSEM-----AIFLMgVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLM---------- 246
Cdd:cd14993  158 --------TEDWPSPElrkayNVALF-VVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRILrskkkvarml 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242397478 247 --VVILF-------YGSGIITYMTPKSSKEQEKLVSVFYAMVTPM------LNPLIYSLRNK 293
Cdd:cd14993  229 ivVVVLFalswlpyYVLSILLDFGPLSSEESDENFLLILPFAQLLgysnsaINPIIYCFMSK 290

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

26-227

5.36e-10

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 59.10 E-value: 5.36e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPqalihlLSRKKTIS----FRRCAAQL 101
Cdd:cd15055    2 LLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP------FSMIRSIEtcwyFGDTFCKL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 102 LLFLIFGCTQCAL--LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVdttftlrlpyrgsnsIAHFFC 179
Cdd:cd15055   76 HSSLDYILTSASIfnLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSV---------------LLYDNL 140

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 242397478 180 EAPALLALASTDTQTSEMAIFLMGVVILL----IPVSLILVSYGHIIVTVVK 227
Cdd:cd15055  141 NQPGLIRYNSCYGECVVVVNFIWGVVDLVltfiLPCTVMIVLYMRIFVVARS 192

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

26-157

5.36e-10

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 58.88 E-value: 5.36e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCaaQLLLFL 105
Cdd:cd15064    2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLC--DIWISL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 242397478 106 IFGCTQCAL--LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15064   80 DVTCCTASIlhLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISL 133

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

36-149

1.19e-09

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 57.95 E-value: 1.19e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  36 MVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGCTQCALL 115
Cdd:cd15318   12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHL 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 242397478 116 AVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSW 149
Cdd:cd15318   92 CFISIDRHCAICDPLLYPSKFTIRVACIFIAAGW 125

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

27-156

2.04e-09

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 57.36 E-value: 2.04e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15312    3 MYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMM 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15312   83 LSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFA 132

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

34-222

2.33e-09

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 57.30 E-value: 2.33e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTIsFRRCAAQLLLFLIFGCTQCA 113
Cdd:cd14997   10 IFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWL-LGEFMCKLVPFVELTVAHAS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 114 LLAVM--SYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPAllalastD 191
Cdd:cd14997   89 VLTILaiSFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGTPVAVCRTPA-------D 161

                        170       180       190
                 ....*....|....*....|....*....|.
gi 242397478 192 TQTSEMAIFLMGVVILLIPVSLILVSYGHII 222
Cdd:cd14997  162 TFWKVAYILSTIVVFFVVPLAILSGLYSVIC 192

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

26-149

3.39e-09

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 56.69 E-value: 3.39e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15317    2 IIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSW 149
Cdd:cd15317   82 LLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGW 125

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

29-299

4.31e-09

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 56.48 E-value: 4.31e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKK-TISFRRCAAQLLLFLIF 107
Cdd:cd15304    5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 108 GCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSvvdttftLRLPYRGSNSIAHFFCEAPALLAl 187
Cdd:cd15304   85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGIS-------MPIPVFGLQDDSKVFKEGSCLLA- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 188 astdtqtSEMAIFLMGVVILLIPVSLILVSYGHIIVTVvkMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKE 267
Cdd:cd15304  157 -------DENFVLIGSFVAFFIPLTIMVITYFLTIKSL--QQSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVICKE 227

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 242397478 268 --QEKLVS------VFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15304  228 scNEVVIGgllnvfVWIGYLSSAVNPLVYTLFNKTYRSAF 267

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

30-299

5.79e-09

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 55.76 E-value: 5.79e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLG-IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFlIFG 108
Cdd:cd15330    5 LFLGtLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALD-VLC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSvVDTTFTLRLPYRGSNSIAHFFCEAPALlal 187
Cdd:cd15330   84 CTSSILhLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSIS-IPPMLGWRTPEDRSDPDACTISKDPGY--- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 188 astdTQTSEMAIFlmgvvilLIPVSLILVSYGHIivtvvkMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKE 267
Cdd:cd15330  160 ----TIYSTFGAF-------YIPLILMLVLYGRI------FKAAARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCES 222

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 242397478 268 QEKLVSVFYAMVT------PMLNPLIYSLRNKDVKGAL 299
Cdd:cd15330  223 TCHMPELLGAIINwlgysnSLLNPIIYAYFNKDFQSAF 260

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

27-299

5.88e-09

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 56.18 E-value: 5.88e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIymVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFS-TNIVPQALIHLLsRKKTIsFRRCAAQLLLFL 105
Cdd:cd15337    5 IYIAIVGI--LGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSaVNGFPLKTISSF-NKKWI-WGKVACELYGFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 --IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVvdttftlrLPYRGsnsIAHFFCEapA 183
Cdd:cd15337   81 ggIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSI--------PPFFG---WGRYVPE--G 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 184 LLALASTD--TQTSEMAIFLMGVVIL--LIPVSLILVSYGHIIVTVVK------------------------------MK 229
Cdd:cd15337  148 FQTSCTFDylSRDLNNRLFILGLFIFgfLCPLLIIIFCYVNIIRAVRNhekemtqtaksgmgkdtekndarkkaeiriAK 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 230 SAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKeqeklVSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15337  228 VAIILISLFLLSWTPYAVVALLGQFGPAYWITPYVSE-----LPVMFAKASAIYNPIIYALSHPKFRAAL 292

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

26-158

1.03e-08

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 55.54 E-value: 1.03e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15058    2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMT-WRVCIQLATVsWTSGILVSVV 158
Cdd:cd15058   82 LCVTASIETLCVIAVDRYIAITRPLRYQVLLTkRRARVIVCVV-WIVSALVSFV 134

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

26-298

1.03e-08

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 55.01 E-value: 1.03e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIymVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKK-TISFRRCAAQLLLF 104
Cdd:cd15052    4 ALLLLLLVI--ATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGVwPLPLVLCLLWVTLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPyrgSNSIAHFFC--EAP 182
Cdd:cd15052   82 VLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDT---TNVLNNGTCvlFNP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 183 ALLALAStdtqtsemaiflmgVVILLIPVSLILVSYGhiivtvVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTP 262
Cdd:cd15052  159 NFVIYGS--------------IVAFFIPLLIMVVTYA------LTIRLLSNEQKASKVLGIVFAVFVICWCPFFITNILT 218

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 242397478 263 KSSKE-----QEKLVSVFYAM--VTPMLNPLIYSLRNKDVKGA 298
Cdd:cd15052  219 GLCEEcncriSPWLLSVFVWLgyVSSTINPIIYTIFNKTFRRA 261

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

34-157

3.85e-08

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 53.39 E-value: 3.85e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFST-NIVPQALIhllsrkkTISFRRCAAQLL--------LF 104
Cdd:cd15196   10 ILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALfNVLPQLIW-------DITYRFYGGDLLcrlvkylqVV 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 242397478 105 LIFGCTQcaLLAVMSYDRYVAICNPLHySSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15196   83 GMYASSY--VLVATAIDRYIAICHPLS-SHRWTSRRVHLMVAIAWVLSLLLSI 132

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

30-158

4.08e-08

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 53.26 E-value: 4.08e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGC 109
Cdd:cd15103    6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIDNVIDSM 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 242397478 110 TQCALLA------VMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVV 158
Cdd:cd15103   86 ICSSLLAsicsllAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGIL 140

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

25-235

4.08e-08

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 53.49 E-value: 4.08e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKktISFRRCAAQLLLF 104
Cdd:cd15083    1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGR--WIFGKTGCDMYGF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 L--IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVdttftlrlPYRGSNSiahFFCEap 182
Cdd:cd15083   79 SggLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLP--------PLFGWSR---YVLE-- 145

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 242397478 183 ALLALASTD----TQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRF 235
Cdd:cd15083  146 GLLTSCSFDylsrDDANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEM 202

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

29-218

6.17e-08

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 52.85 E-value: 6.17e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVP-QALIHLLSRKKTISFRRCAAQLLLFLIF 107
Cdd:cd14971    5 LFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPfTATIYPLPGWVFGDFMCKFVHYFQQVSM 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 108 GCTqCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV-VDTTFTLRLPYRGSNSIAHFFCEAPAlla 186
Cdd:cd14971   85 HAS-IFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAApVLALHRLRNYTPGNRTVCSEAWPSRA--- 160

                        170       180       190
                 ....*....|....*....|....*....|...
gi 242397478 187 lastdtqtSEMAIFLMGVVIL-LIPVSLILVSY 218
Cdd:cd14971  161 --------HRRAFALCTFLFGyLLPLLLICVCY 185

7tmA_AstC_insect

cd15094

somatostatin-like receptor for allatostatin C, member of the class A family of ...

29-296

6.34e-08

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.

Pssm-ID: 320222 [Multi-domain] Cd Length: 282 Bit Score: 52.86 E-value: 6.34e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIvPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15094    5 VLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGL-PFLIVTMILKYWPFGAAMCKIYMVLTSINQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALA 188
Cdd:cd15094   84 FTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSSAVNGQK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 189 STDTQTsemaiFLMGvviLLIPVSLILVSYghiIVTVVKMKSAAGRFKAFSTCGSHLMV------VI-------LFYGSG 255
Cdd:cd15094  164 AFTLYT-----FLLG---FAIPLLLISVFY---TLVILRLRTVGPKNKSKEKRRSHRKVtrlvltVIsvyiicwLPYWAF 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 242397478 256 IITYMTPKSSKEQEKLVSVFYAMVT------PMLNPLIYSLRNKDVK 296
Cdd:cd15094  233 QVHLIFLPPGTDMPKWEILMFLLLTvlsyanSMVNPLLYAFLSENFR 279

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

29-150

7.78e-08

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 53.03 E-value: 7.78e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYM-VTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKK-TISFRRCAAQLLLFLI 106
Cdd:cd15217    4 LVLLGLIIcVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWT 150
Cdd:cd15217   84 FCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWT 127

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

26-158

8.26e-08

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 52.72 E-value: 8.26e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLG-IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15051    1 IVLGVVLAvIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 242397478 105 LIFgCTQCAL-LAVMSYDRYVAICNPLHYSSTMT-WRVCIQLATVsWTSGILVSVV 158
Cdd:cd15051   81 VML-CTASILnLFAISLDRYLAITAPLRYPSRVTpRRVAIALAAI-WVVSLAVSFL 134

7tmA_AstA_R_insect

cd15096

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...

29-240

1.28e-07

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320224 [Multi-domain] Cd Length: 284 Bit Score: 51.91 E-value: 1.28e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLsrKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYV--LPTWPFGDVWCKIVQYLVYV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCAL--LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSgILVSVVDTTFTLRLPYRGSNSIAHFFCeapALLA 186
Cdd:cd15096   83 TAYASVytLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIV-ILVANIPVLFLHGVVSYGFSSEAYSYC---TFLT 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 242397478 187 LASTDTQTSEMAIFLMGVVillIPVSLILVSYGHIIVTVVKMKSAAGRFKAFST 240
Cdd:cd15096  159 EVGTAAQTFFTSFFLFSYL---IPLTLICVLYMLMLRRLRRQKSPGGRRSAESQ 209

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

26-157

2.62e-07

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 51.20 E-value: 2.62e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLsRKKTISFRRCAAQLLLFL 105
Cdd:cd14979    2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFW-WQYPWAFGDGGCKLYYFL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 242397478 106 IFGCTQCALLAV--MSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd14979   81 FEACTYATVLTIvaLSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAI 134

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

30-162

4.46e-07

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 50.18 E-value: 4.46e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGC 109
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMDNVIDTM 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 242397478 110 TQCALLAVMSY------DRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTF 162
Cdd:cd15351   86 ICSSVVSSLSFlgaiavDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVY 144

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

30-158

4.86e-07

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 50.27 E-value: 4.86e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFST-NIVPQALIHLL-SRKKTISFRRCAAQLLLFLIF 107
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVsNSLETIMIAVLnSGYLVISDQFIQHMDNVFDSM 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 242397478 108 GCTQ-----CALLAVmSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVV 158
Cdd:cd15352   86 ICISlvasiCNLLAI-AVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIV 140

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

29-306

5.29e-07

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 50.22 E-value: 5.29e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKK-TISFRRCAAQLLLFLIF 107
Cdd:cd15306    5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFLDVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 108 GCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWtsgilvsVVDTTFTLRLPYRGSNSIAHFFCEAPALLAl 187
Cdd:cd15306   85 STASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVW-------LISIGIAIPVPIKGIETDVDNPNNITCVLT- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 188 astdTQTSEMAIFLMGVVILLIPVSLILVSYgHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMT-----P 262
Cdd:cd15306  157 ----KERFGDFILFGSLAAFFTPLAIMIVTY-FLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNITsvlcdS 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 242397478 263 KSSKEQEKLVSVF--YAMVTPMLNPLIYSLRNKDVKGALWKVATKN 306
Cdd:cd15306  232 CNQTTLQMLMEIFvwIGYVSSGVNPLVYTLFNKTFRDAFGRYITCN 277

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

26-157

6.10e-07

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 49.89 E-value: 6.10e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVP-QALIHLLSRkktISFRRCAAQLLLF 104
Cdd:cd15325    2 VLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPfSAIFEILGY---WAFGRVFCNIWAA 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 242397478 105 L-IFGCTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15325   79 VdVLCCTASIMsLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISI 133

7tmA_Histamine_H3R_H4R

cd15048

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...

26-155

7.07e-07

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320176 [Multi-domain] Cd Length: 296 Bit Score: 49.99 E-value: 7.07e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLL-F 104
Cdd:cd15048    2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVdY 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 242397478 105 LIfgCTQCALLAVM-SYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILV 155
Cdd:cd15048   82 TL--CTASALTIVLiSLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLL 131

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

26-157

7.20e-07

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 49.58 E-value: 7.20e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRC----AAQL 101
Cdd:cd15329    2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCdvwiSFDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 242397478 102 LLflifgCTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15329   82 LL-----CTASILnLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISI 133

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

29-302

1.13e-06

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 49.18 E-value: 1.13e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15307    5 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVvdtTFTLRLPYRGSNSIAHFFCEAPALLALa 188
Cdd:cd15307   85 TASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL---PLSLMYSKDHASVLVNGTCQIPDPVYK- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 189 stdtqtsemaiFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRF-----KAFSTCGSHLMVVILFYGSGIITYMTPK 263
Cdd:cd15307  161 -----------LVGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIirleqKATKVLGVVFFTFVILWSPFFVLNLLPT 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 242397478 264 SSKEQEKLVS-------VFYAMVTPMLNPLIYSLRNKDVKGALWKV 302
Cdd:cd15307  230 VCAECEERIShwvfdvvTWLGYASSMVNPIFYTIFNKVFRQAFKKV 275

7tmA_Gal2_Gal3_R

cd15097

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...

29-293

1.17e-06

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320225 [Multi-domain] Cd Length: 279 Bit Score: 49.05 E-value: 1.17e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGN-LFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVP-QALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15097    5 VVFSLIFLLGTVGNsLVLAVLLRSGQSGHNTTNLFILNLSVADLCFILFCVPfQATIYSLEGWVFGSFLCKAVHFFIYLT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVmSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYrGSNSIAHFFCEAPALLA 186
Cdd:cd15097   85 MYASSFTLAAV-SVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDY-ANSTVCMPGWEEARRKA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 187 LastDTQTsemaiFLMGvviLLIPVSLILVSYGHII----VTVVKMKSAAGRFKAFSTCGSHLMVV-ILF------YGSG 255
Cdd:cd15097  163 M---DTCT-----FAFG---YLIPVLVVSLSYTRTIkylwTAVDPLEAMSESKRAKRKVTKMIIIVtALFclcwlpHHVV 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 242397478 256 IITYMTPKSSKEQE----KLVSVFYAMVTPMLNPLIYSLRNK 293
Cdd:cd15097  232 ILCYLYGDFPFNQAtyafRLLSHCMAYANSCLNPIVYALVSK 273

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

26-288

1.36e-06

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 48.80 E-value: 1.36e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFsTNIVPQALIHLLSRKKTISFRR-CAAQLLLF 104
Cdd:cd14982    2 LFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLF-VLTLPFRIYYYLNGGWWPFGDFlCRLTGLLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSgILVSVVDTTFTLRLPYRGSNSIAHFFceapal 184
Cdd:cd14982   81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWIL-VLVASVPLLLLRSTIAKENNSTTCFE------ 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 lALASTDTQTSEMAIFLMgVVILLIPVSLILVSYGHIIVTVVKMKSAAG----RFKAFSTCGSHLMVVILFYG------- 253
Cdd:cd14982  154 -FLSEWLASAAPIVLIAL-VVGFLIPLLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVFLVCFLpyhvtri 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 242397478 254 ------SGIITYMTPKSSKEQEKLVSVFYAMVTPMLNPLIY 288
Cdd:cd14982  232 lyllvrLSFIADCSARNSLYKAYRITLCLASLNSCLDPLIY 272

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

27-293

1.55e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 48.81 E-value: 1.55e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIymVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15074    5 IYLTVIGI--LSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNP-----LHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTlrlPYRGSnsiahffCEA 181
Cdd:cd15074   83 FGCCSINTLTAISIYRYLKICHPpygpkLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYGPE---PFGTS-------CSI 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 182 PALLALASTDTQTSEMAIFlmgVVILLIPVSLILVSYGHIIVTVvkmKSAAGRFKAFSTCGSH------------LMVVI 249
Cdd:cd15074  153 DWTGASASVGGMSYIISIF---IFCYLLPVLIIVFSYVKIIRKV---KSSRKRVAGFDSRSKRqhkierkvtkvaVLICA 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 242397478 250 LFYGS----GIITYMTPKSSKEQ-EKLVSVFYAMV---TPMLNPLIYSLRNK 293
Cdd:cd15074  227 GFLIAwtpyAVVSMWSAFGSPDSvPILASILPALFaksSCMYNPIIYLLFSS 278

7tmA_alpha1D_AR

cd15327

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

30-157

2.00e-06

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320450 [Multi-domain] Cd Length: 261 Bit Score: 48.37 E-value: 2.00e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLGIY-MVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVP-QALIHLLSrkkTISFRRCAAQLLLFL-I 106
Cdd:cd15327    5 VFLAIFiLMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPfSATLEVLG---FWAFGRVFCDIWAAVdV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 242397478 107 FGCTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15327   82 LCCTASILsLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISI 133

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

30-150

2.31e-06

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 48.01 E-value: 2.31e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFS-TNIVPQALIHLLSRKKTI---SFRRCAAQLLLFL 105
Cdd:cd15354    6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSvSNAWETITIYLLNNRHLViedAFVRHIDNVFDSL 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 242397478 106 I---FGCTQCALLAVmSYDRYVAICNPLHYSSTMTWRVCIQLATVSWT 150
Cdd:cd15354   86 IcisVVASMCSLLAI-AVDRYVTIFYALRYHNIMTVRRAGIIIACIWT 132

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

34-296

2.34e-06

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 48.24 E-value: 2.34e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALihLLSRKKTISFRRCAAQLLLFLIFGCTQCA 113
Cdd:cd15070   10 IGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAI--VVSLGVTIHFYSCLFMSCLLVVFTHASIM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 114 LLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALLALastdtq 193
Cdd:cd15070   88 SLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFTSVMRM------ 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 194 tsEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKS-------AAGRF--KAFSTCGSHLMVVILFYGSGI-------I 257
Cdd:cd15070  162 --DYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSqnatgfrETGAFygREFKTAKSLALVLFLFAVCWLplsiincV 239

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 242397478 258 TYMTPKSSKEQeKLVSVFYAMVTPMLNPLIYSLRNKDVK 296
Cdd:cd15070  240 VYFNPKVPKIA-LYLGILLSHANSMMNPIVYACKIKKFK 277

7tmA_5-HT1F

cd15334

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...

26-299

2.36e-06

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320456 [Multi-domain] Cd Length: 259 Bit Score: 48.02 E-value: 2.36e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLsrKKTISFRRCAAQLLLFL 105
Cdd:cd15334    2 LISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIV--KETWIMGQVVCDIWLSV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALL--AVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVvdttftlrlpyrgsnsiahffceaPA 183
Cdd:cd15334   80 DITCCTCSILhlSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISM------------------------PP 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 184 LLALASTDTQTSEMAIFLMGVVILL--------IPVSLILVSYGHIIVTVVKMKSAAGRFKAFstCGSHLMVVILFYGSG 255
Cdd:cd15334  136 LFWRHQTTSREDECIIKHDHIVFTIystfgafyIPLALILILYYKIYRAATRERKAATTLGLI--LGAFVICWLPFFVKE 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 242397478 256 IITYMTPK--SSKEQEKLVSvFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15334  214 VIVNTCDScyISEEMSNFLT-WLGYINSLINPLIYTIFNEDFKKAF 258

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

26-157

2.56e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 48.01 E-value: 2.56e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIymvtvLGNLFLMFlVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd14978    7 LPVICIFGI-----IGNILNLV-VLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPYI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 242397478 106 IF--GCTQCA---LLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd14978   81 YPlaNTFQTAsvwLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNL 137

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

34-224

2.78e-06

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 48.19 E-value: 2.78e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMY-FFLCNLSLADLCFSTNIVPQALIHLLSrkKTISFRRCAAQLLLFLIFGCTQC 112
Cdd:cd15057   10 LVLLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAILVMPWAAVNEVA--GYWPFGSFCDVWVSFDIMCSTAS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 113 AL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVdtTFTLRLPYRGSNSIAHFFCEAPAL--LALAS 189
Cdd:cd15057   88 ILnLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFI--PVQLGWHRADDTSEALALYADPCQcdSSLNR 165

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 242397478 190 TDTQTSEMAIFlmgvvilLIPVSLILVSYGHIIVT 224
Cdd:cd15057  166 TYAISSSLISF-------YIPVAIMIVTYTRIYRI 193

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

25-299

2.83e-06

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 47.85 E-value: 2.83e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADL----CFSTNIvpqalihLLSRKKTISFRRC--- 97
Cdd:cd15102    1 GATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLlagaAYLANI-------LLSGARTLRLSPAqwf 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  98 AAQLLLFLIFGCTQCALLAVmSYDRYVAICNPLHYSSTMTWRVcIQLATVSWTSGILVSVvdttftlrLPYRGSNSIAHf 177
Cdd:cd15102   74 LREGSMFVALSASVFSLLAI-AIERHLTMAKMKPYGASKTSRV-LLLIGACWLISLLLGG--------LPILGWNCLGA- 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 178 fceapalLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTV----VKMKSAAGRFKAFSTCGSHLMVVILFYG 253
Cdd:cd15102  143 -------LDACSTVLPLYSKHYVLFCVTIFAGILAAIVALYARIYCLVrasgRKATRASASPRSLALLKTVLIVLLVFIA 215

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 242397478 254 S-----GIITYMTPKSSKEQEKLVSVFY----AMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15102  216 CwgplfILLLLDVACPVKTCPILYKADWflalAVLNSALNPIIYTLRSRELRRAV 270

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

28-275

3.14e-06

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 47.80 E-value: 3.14e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  28 FILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFS-TNIVPQalihlLSRKKTISFRR--CAAQLLLF 104
Cdd:cd15197    4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGlINVLTD-----IIWRITVEWRAgdFACKVIRY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCA--LLAVMSYDRYVAICNPLHYSStmTWRVCIQLATVSWTSGILVSVVdttfTLRLPYRGSNSIAHFFCeap 182
Cdd:cd15197   79 LQVVVTYAStyVLVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSALFSIP----MLIIFEKTGLSNGEVQC--- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 183 alLALASTDTQTsEMAIFLMGVVILLIPVSLILVSYGhIIVTVVKMKSAAgrFKAFSTCGSHLMVVILFYGSGIITYMTP 262
Cdd:cd15197  150 --WILWPEPWYW-KVYMTIVAFLVFFIPATIISICYI-IIVRTIWKKSKI--QVTINKAGLHDGSSRRSSSRGIIPRAKI 223

                        250
                 ....*....|...
gi 242397478 263 KSSKEQEKLVSVF 275
Cdd:cd15197  224 KTIKMTFVIVTVF 236

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

32-227

3.26e-06

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 47.76 E-value: 3.26e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  32 LGIYMV-TVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFS-TNIVPQALIHLLSRKKTISFR-RCAAQLLLFLIFG 108
Cdd:cd14986    7 LGVLFVfTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEATGEWVAGDVLcRIVKYLQVVGLFA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQcaLLAVMSYDRYVAICNPLHySSTMTWRVCIqLATVSWTSGILVSVVDttftlrlpyrgsnsiAHFFCE------AP 182
Cdd:cd14986   87 STY--ILVSMSLDRYQAIVKPMS-SLKPRKRARL-MIVVAWVLSFLFSIPQ---------------LVIFVErelgdgVH 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 242397478 183 ALLALASTDTQTSEMAIFLMgVVILLIPVSLILVSYGHIIVTVVK 227
Cdd:cd14986  148 QCWSSFYTPWQRKVYITWLA-TYVFVIPLIILSYCYGRILRTIWI 191

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

29-222

3.57e-06

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 47.67 E-value: 3.57e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFsTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd14970    5 AVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLhysSTMTWRVCIQLATVS---WTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPall 185
Cdd:cd14970   84 FTSIFCLTVMSVDRYLAVVHPV---KSLRFRTPRKAKLVSlcvWALSLVLGLPVIIFARTLQEEGGTISCNLQWPDP--- 157

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 242397478 186 alASTDTQTSEMAIFLMGVVillIPVSLILVSYGHII 222
Cdd:cd14970  158 --PDYWGRVFTIYTFVLGFA---VPLLVITVCYSLII 189

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

33-157

3.59e-06

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 47.48 E-value: 3.59e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  33 GIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIhlLSRKKTISFRRCAAQLLLFL-IFGCTQ 111
Cdd:cd15062    9 AFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSAT--LEVLGYWAFGRIFCDVWAAVdVLCCTA 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 242397478 112 CAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15062   87 SIMsLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISI 133

7tmA_capaR

cd15134

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...

26-225

4.67e-06

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.

Pssm-ID: 320262 [Multi-domain] Cd Length: 298 Bit Score: 47.33 E-value: 4.67e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSrKKTISFRRCAAQLLLFL 105
Cdd:cd15134    2 PITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQ-QYPWVFGEVFCKLRAFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAV--MSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV-----VDTTFTLRLPYRGSNSIAHFF 178
Cdd:cd15134   81 SEMSSYASVLTItaFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALpfaiqTRIVYLEYPPTSGEALEESAF 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 242397478 179 CEAPallalasTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTV 225
Cdd:cd15134  161 CAML-------NEIPPITPVFQLSTFLFFIIPMIAIIVLYVLIGLQL 200

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

26-156

5.17e-06

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 46.97 E-value: 5.17e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSrkKTISFRRCAAQLLLFL 105
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLL--GYWPLGSHLCDFWISL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 242397478 106 -IFGCTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15061   79 dVLLCTASILnLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLIT 131

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

34-234

5.83e-06

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 47.10 E-value: 5.83e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFST-NIVPQALIHLLSRKKTISFR-RCAAQLLLFLIFGCTQ 111
Cdd:cd15386   10 ILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLIWEITYRFQGPDLLcRAVKYLQVLSMFASTY 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 112 caLLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIA-----HFFCEAPALLa 186
Cdd:cd15386   90 --MLIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGATWLLSCILSLPQVFIFSLREVDQGSGVLDcwadfGFPWGAKAYI- 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 242397478 187 lastdTQTSeMAIFLMGVVILLIPVSLILvsygHIIVTVVKMKSAAGR 234
Cdd:cd15386  167 -----TWTT-LSIFVLPVAILIVCYSLIC----YEICKNLKGKTQTSR 204

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

26-225

6.19e-06

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 46.97 E-value: 6.19e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLsrkktisfrrcaaqLLLFL 105
Cdd:cd15392    2 IIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALL--------------ILQYW 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCAL---------------LAVMSYDRYVAICNPLhySSTMTWRVCIQLATVSWTSGILVSvVDTTFTLRLPYRG 170
Cdd:cd15392   68 PFGEFMCPVvnylqavsvfvsaftLVAISIDRYVAIMWPL--RPRMTKRQALLLIAVIWIFALATA-LPIAITSRLFEDS 144

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 242397478 171 SNSIAHFFCeapallalasTDTQTSEMAIFLMGVVILL----IPVSLILVSYGHIIVTV 225
Cdd:cd15392  145 NASCGQYIC----------TESWPSDTNRYIYSLVLMIlqyfVPLAVLVFTYTRIGIVV 193

7tmA_NMBR

cd15125

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...

30-227

7.00e-06

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.

Pssm-ID: 320253 [Multi-domain] Cd Length: 292 Bit Score: 46.87 E-value: 7.00e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGC 109
Cdd:cd15125    6 LYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 110 TQCALLAVMSYDRYVAICNPLHY-SSTMTWRVCIQLATVsWTSGILVSVVDTTFTlRLPYRGSNSIAHFfceaPALLALA 188
Cdd:cd15125   86 VSVFTLTALSADRYKAIVNPMDIqTSSAVLRTCLKAIAI-WVVSVLLAVPEAVFS-EVAHIMPDDNTTF----TACIPYP 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 242397478 189 STDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVK 227
Cdd:cd15125  160 QTDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIK 198

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

36-299

7.78e-06

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 46.45 E-value: 7.78e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  36 MVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGCTQCALL 115
Cdd:cd15321   18 LFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 116 AVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDttftlrLPYRGSNSiahffceaPALLALASTDTQTS 195
Cdd:cd15321   98 CAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPP------LIYKGKQK--------DEQGGLPQCKLNEE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 196 EMAIFLMGVVILLIPVSLILVSYGHIIVtVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKEQEKLVSVF 275
Cdd:cd15321  164 AWYILSSSIGSFFAPCLIMILVYLRIYL-IAKNREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPELCKVPHSLFQFF 242

                        250       260
                 ....*....|....*....|....*.
gi 242397478 276 Y--AMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15321  243 FwiGYCNSSLNPVIYTIFNQDFRRAF 268

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

30-155

8.35e-06

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 46.31 E-value: 8.35e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFS-TNIVPQALIHL-----LSRKKTISFRRCAAQLLL 103
Cdd:cd15350    6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSlYKTLENILIILadmgyLNRRGPFETKLDDIMDSL 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 242397478 104 FLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWT----SGILV 155
Cdd:cd15350   86 FCLSLLGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTfcggSGILM 141

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

34-156

8.79e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 46.34 E-value: 8.79e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAqLLLFLIFGCTQCA 113
Cdd:cd15054   10 IILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPI-WYAFDVMCCSASI 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 242397478 114 L-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15054   89 LnLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALAS 132

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

26-288

9.12e-06

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 46.47 E-value: 9.12e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHllsrkktiSFRRCAAQLLLFL 105
Cdd:cd15314    2 LLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVR--------SVETCWYFGDLFC 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 -------IFGCTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAhf 177
Cdd:cd15314   74 kihssfdITLCTASILnLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELNIKGIYYNHVA-- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 178 fCEAPALLALastdtqtSEMAIFLMGVVILLIPVSLILVSYGHI----------IVTVVKMKSAAGRFK----------- 236
Cdd:cd15314  152 -CEGGCLVFF-------SKVSSVVGSVFSFYIPAVIMLCIYLKIflvaqrqarsIQSARTKSGASSSKMerkatktlaiv 223

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 242397478 237 --AFSTCGSHLMVVILFYGsgIITYMTPKSSKEqeklVSVFYAMVTPMLNPLIY 288
Cdd:cd15314  224 mgVFLLCWTPFFLCNIIDP--FINYSIPPVLIE----VLNWLGYSNSTLNPFIY 271

7tmA_5-HT1E

cd15335

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...

34-157

9.79e-06

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320457 [Multi-domain] Cd Length: 258 Bit Score: 46.07 E-value: 9.79e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIfgCTQCA 113
Cdd:cd15335   10 ITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMT--CCTCS 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 242397478 114 L--LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15335   88 IlhLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISI 133

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

34-221

1.00e-05

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 46.35 E-value: 1.00e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFST-NIVPQALIHLLSRKKTISFR-RCAAQLLLFLIFGCTQ 111
Cdd:cd15385   10 IFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLPQLCWDITYRFYGPDFLcRIVKHLQVLGMFASTY 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 112 caLLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGS---NSIAHFFceapallala 188
Cdd:cd15385   90 --MLVMMTADRYIAICHPLKTLQQPTKRSYLMIGSAWALSFILSTPQYFIFSLSEIENGSgvyDCWANFI---------- 157

                        170       180       190
                 ....*....|....*....|....*....|...
gi 242397478 189 stDTQTSEMAIFLMGVVILLIPVSLILVSYGHI 221
Cdd:cd15385  158 --VPWGIKAYITWITISIFVVPVIILLTCYGFI 188

7tmA_D1A_dopamine_R

cd15320

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

25-221

1.08e-05

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320443 [Multi-domain] Cd Length: 319 Bit Score: 46.54 E-value: 1.08e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMV-TVLGNLFLMFLVRADSRLHTPMY-FFLCNLSLADLCFSTNIVP-QALIHLLSRKKTISFrrCAAQL 101
Cdd:cd15320    1 RVLTGCFLSVLILsTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPwKAVAEIAGFWPFGSF--CNIWV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 102 LLFLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVdttfTLRLPYRGSNSIAHFFCEA 181
Cdd:cd15320   79 AFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFI----PVQLNWHKAKPTSFLDLNA 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 242397478 182 PAL-LALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHI 221
Cdd:cd15320  155 SLRdLTMDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRI 195

7tmA_GPR135

cd15212

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...

29-156

1.08e-05

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320340 [Multi-domain] Cd Length: 285 Bit Score: 46.30 E-value: 1.08e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTI-SFRRCAAQLLLFLIF 107
Cdd:cd15212    5 LVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLfGDRLCLANGFFNACF 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 242397478 108 GCTQCALLAVMSYDRYVAICNPLHysSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15212   85 GIVSTLTMTLISFDRYYAIVRQPQ--GKIGRRRALQLLAAAWLTALGFS 131

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

28-228

1.16e-05

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 46.11 E-value: 1.16e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  28 FILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVP-QALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15001    3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPlKTAEYFSPTWSLGAFLCKAVAYLQLLS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTqCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEapalla 186
Cdd:cd15001   83 FICS-VLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQ------ 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 242397478 187 LASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHI-IVTVVKM 228
Cdd:cd15001  156 KAWPSTLYSRLYVVYLAIVIFFIPLIVMTFAYARDtRKQVIKM 198

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

28-147

1.24e-05

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 45.86 E-value: 1.24e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  28 FILFLGIymVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIF 107
Cdd:cd15336    6 VILIIGI--TGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALF 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 242397478 108 GCTQCALLAVMSYDRYVAICNPLhysSTMTW----RVCIQLATV 147
Cdd:cd15336   84 GITSMITLLAISLDRYLVITKPL---ASIRWvskkRAMIIILLV 124

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

26-158

1.26e-05

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 46.19 E-value: 1.26e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAqLLLFL 105
Cdd:cd15065    1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNI-WISFD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 242397478 106 IFGCTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVV 158
Cdd:cd15065   80 VMCSTASILnLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFL 133

7tmA_Encephalopsin

cd15078

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...

25-230

1.47e-05

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320206 [Multi-domain] Cd Length: 279 Bit Score: 45.59 E-value: 1.47e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15078    1 ELLALLIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVC--IQLATVSWTSGILVSVVDTTFtlrlpyrgsnSIAHFFCEap 182
Cdd:cd15078   81 SLFGIVSIMTLTVLAYERYIRVVHAKVVNFSWSWRAItyIWLYSLAWTGAPLLGWNRYTL----------EVHGLGCS-- 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 242397478 183 alLALASTDTQTSEMAIFLMgVVILLIPVSLILVSYGHIIVTVVKMKS 230
Cdd:cd15078  149 --FDWKSKDPNDTSFVLLFF-LGCLVVPLGIMAYCYGHILYEIRMLRS 193

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

26-130

1.90e-05

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 45.36 E-value: 1.90e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15390    2 LWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAI 81

                         90       100
                 ....*....|....*....|....*
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPL 130
Cdd:cd15390   82 TTVAASVFTLMAISIDRYIAIVHPL 106

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

29-296

1.99e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 45.31 E-value: 1.99e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIhlLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15069    5 ALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAIT--ISLGFCTDFHSCLFLACFVLVLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWtsgILVSVVDTTftlrlPYRGSNS--IAHFFCEAPA--- 183
Cdd:cd15069   83 QSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLW---VLAFGIGLT-----PFLGWNKamSATNNSTNPAdhg 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 184 -------LLALASTDTQTSEMAIF-LMGVVilLIPVSLILVSYGHIIVTVVKM--------KSAAGRFKAFSTCGSHLMV 247
Cdd:cd15069  155 tnhscclISCLFENVVPMSYMVYFnFFGCV--LPPLLIMLVIYIKIFLVACRQlqrtelmdHSRTTLQREIHAAKSLAII 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 242397478 248 VILF-------YGSGIITYMTPKSSKEQEKL---VSVFYAMVTPMLNPLIYSLRNKDVK 296
Cdd:cd15069  233 VGIFalcwlpvHILNCITLFQPEFSKSKPKWamnVAILLSHANSVVNPIVYAYRNRDFR 291

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

26-296

2.79e-05

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 44.96 E-value: 2.79e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIY-MVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd17790    1 VLIVITTGILsLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTlrlpyrgsnsiAHFFCEAPAL 184
Cdd:cd17790   81 YVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFW-----------QYLVGERTVL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 185 LALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFstcgshLMVVILFYGSGIITYMTPKS 264
Cdd:cd17790  150 AGQCYIQFLSQPIITFGTAIAAFYLPVTIMIILYWRIYRETIKEKKAARTLSAI------LLAFILTWTPYNIMVLVSTF 223

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 242397478 265 SKE--QEKLVSVFYAM--VTPMLNPLIYSLRNKDVK 296
Cdd:cd17790  224 CKDcvPKTLWELGYWLcyVNSTVNPMCYALCNKSFR 259

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

36-156

2.93e-05

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 44.90 E-value: 2.93e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  36 MVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGCTQCALL 115
Cdd:cd15959   12 LVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 242397478 116 AVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15959   92 CAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAIS 132

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

30-154

3.42e-05

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 44.51 E-value: 3.42e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFS-TNIVPQALIHLLSRKKT--ISFRRCAAQLLLFLI 106
Cdd:cd15353    6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSvSNGSETVVITLLNGNDTdaQSFTVNIDNVIDSVI 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 242397478 107 FG---CTQCALLAVmSYDRYVAICNPLHYSSTMTWRVCIQLATVSWT----SGIL 154
Cdd:cd15353   86 CSsllASICSLLSI-AVDRYFTIFYALQYHNIMTVRRAGVIITCIWTactvSGVL 139

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

26-157

3.43e-05

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 44.34 E-value: 3.43e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAqLLLFL 105
Cdd:cd15060    2 VTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQM-WLTCD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 242397478 106 IFGCTQCAL-LAVMSYDRYVAICNPLHYSSTMTW-RVCIQLATVsWTSGILVSV 157
Cdd:cd15060   81 ILCCTASILnLCAIALDRYWAIHDPINYAQKRTLkRVLLMIVVV-WALSALISV 133

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

28-295

3.53e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 44.54 E-value: 3.53e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  28 FILFLGIYMVT-VLGNLFLMFLVRADSRLH--TPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRR-CAAQLLL 103
Cdd:cd14981    3 SPAPPALMFVFgVLGNLLALIVLARSSKSHkwSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDGGQPlCDYFGFM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 104 FLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVvdttftlrLPYRGSNSIAHFFCEAPA 183
Cdd:cd14981   83 MSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAS--------LPLLGLGSYVLQYPGTWC 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 184 LLALASTDTQTSEMAIFLMGVVILLIPVSLILVSYghIIVTVVKMKSAAGRFKA-------------------------F 238
Cdd:cd14981  155 FLDFYSKNTGDAAYAYLYSILGLLILLVTLLCNLL--VIITLLRMRRRKKRHRRsrrsarrqkrneiqmvvlllaitvvF 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 242397478 239 STCGSHLMVVILFYGSGiitymtPKSSKEQEKLVSVFYAMVTPMLNPLIYSLRNKDV 295
Cdd:cd14981  233 SVCWLPLMIRVLINATG------DSEKNGKTDLLAVRMASWNQILDPWVYILLRKEV 283

7tmA_leucokinin-like

cd15393

leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...

26-157

3.58e-05

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.

Pssm-ID: 320515 [Multi-domain] Cd Length: 288 Bit Score: 44.71 E-value: 3.58e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLcfstnivpqaLIHLLSrkktISFRRCAA--QLLL 103
Cdd:cd15393    2 LLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADI----------IIGLFS----IPFQFQAAllQRWV 67

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242397478 104 FLIFGCTQCAL------------LAVMSYDRYVAICNPLhySSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15393   68 LPRFMCPFCPFvqvlsvnvsvftLTVIAVDRYRAVIHPL--KARCSKKSAKIIILIIWILALLVAL 131

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

27-225

3.72e-05

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 44.49 E-value: 3.72e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIymVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIvPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15079    5 FIYIFLGI--VSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGCQIYAFLGSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHySSTMTWRVCIQLATVSWtsgilvsVVDTTFTLRLPYRGSNSIAhffceAPALLA 186
Cdd:cd15079   82 SGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIW-------LYALPWALLPLLFGWGRYV-----PEGFLT 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 242397478 187 LASTD--TQTSEMAIFLMG--VVILLIPVSLILVSYGHIIVTV 225
Cdd:cd15079  149 SCSFDylTRDWNTRSFVATifVFAYVIPLIIIIYCYSFIVKAV 191

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

24-298

4.68e-05

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 44.02 E-value: 4.68e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  24 QKLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLL 103
Cdd:cd15333    4 KISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 104 FLIFgCTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVdttftlrlPYrgsnsiahFFCEAP 182
Cdd:cd15333   84 DITC-CTASILhLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLP--------PF--------FWRQAK 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 183 ALLALASTDTQTSEMAIFLMGVV-ILLIPVSLILVSYGHIIVtvvkmKSAAGRFKAFSTCGSHLMVVIL----FYGSGII 257
Cdd:cd15333  147 AEEEVSECVVNTDHILYTVYSTVgAFYIPTLLLIALYGRIYV-----EARARERKATKTLGIILGAFIVcwlpFFIISLV 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 242397478 258 TYMTPKSSKEQEKLVSVFYAM--VTPMLNPLIYSLRNKDVKGA 298
Cdd:cd15333  222 LPICKDACWFHLAIFDFFTWLgyLNSLINPIIYTMSNEDFKQA 264

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

34-157

4.77e-05

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 44.26 E-value: 4.77e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFgCTQCA 113
Cdd:cd15059   10 VILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLF-CTASI 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 242397478 114 L-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15059   89 VnLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISL 133

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

30-158

5.85e-05

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 43.90 E-value: 5.85e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGC 109
Cdd:cd15066    5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 242397478 110 TQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVV 158
Cdd:cd15066   85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFL 133

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

29-221

6.39e-05

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 43.71 E-value: 6.39e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15978    5 LLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEapallALA 188
Cdd:cd15978   85 SVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMCR-----LLW 159

                        170       180       190
                 ....*....|....*....|....*....|...
gi 242397478 189 STDTQTSEMAIFLMgVVILLIPVSLILVSYGHI 221
Cdd:cd15978  160 PNDVTQQSWYIFLL-LILFLIPGIVMMTAYGLI 191

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

26-165

7.43e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 43.65 E-value: 7.43e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIymvtvLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFStniVPQALIHLLSrkkTISFRRCAAQLLLFL 105
Cdd:cd15387    7 LALILFLAL-----TGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVA---VFQVLPQLIW---DITFRFYGPDFLCRL 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242397478 106 I--------FGCTQcaLLAVMSYDRYVAICNPLHYSSTMTWRVCIqlaTVSWTSGILVSVVDT-TFTLR 165
Cdd:cd15387   76 VkylqvvgmFASTY--MLLLMSIDRCLAICQPLRSLHRRSDRVYV---LFSWLLSLVFSIPQVhIFSLR 139

7tmA_GPR26_GPR78-like

cd15219

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...

26-163

7.50e-05

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320347 [Multi-domain] Cd Length: 264 Bit Score: 43.60 E-value: 7.50e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNL--FLMFLVRADSRLHTPMYFFLcNLSLADLCFSTNIVPQALIHLLSRKKtiSFRRCAAQLLL 103
Cdd:cd15219    1 LLAVLLVVVLVVSLLSNLlvLLCFLYSAELRKQVPGIFLL-NLSFCNLLLTVLNMPFTLLGVVRNRQ--PFGDGFCQAVG 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242397478 104 FL-IFGCTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFT 163
Cdd:cd15219   78 FLeTFLTSNAMLsMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLS 139

7tmA_MCHR-like

cd15088

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...

26-158

8.98e-05

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320216 [Multi-domain] Cd Length: 278 Bit Score: 43.21 E-value: 8.98e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIvpQALIHLLSRKKTISFRRCAAQlLLFL 105
Cdd:cd15088    2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGM--PFLIHQFAIDGQWYFGEVMCK-IITA 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 242397478 106 IFGCTQCA---LLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSW-TSGILVSVV 158
Cdd:cd15088   79 LDANNQFTstyILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWaASFLSILPV 135

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

26-149

9.08e-05

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 43.25 E-value: 9.08e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLG-IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIhlLSRKKTISFRRCAAQLLLF 104
Cdd:cd15063    1 LISLLVLTfLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAV--NEVLDVWIFGHTWCQIWLA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 242397478 105 L-IFGCTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSW 149
Cdd:cd15063   79 VdVWMCTASILnLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVW 125

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

29-251

1.07e-04

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 43.18 E-value: 1.07e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGN---LFLMFLVRADSRLHTPMYFFLcNLSLADLCFSTNIVP-QALIHLLSRKKTISFRrCAAQLLLF 104
Cdd:cd15098    5 VVFGLIFCLGVLGNslvITVLARVKPGKRRSTTNVFIL-NLSIADLFFLLFCVPfQATIYSLPEWVFGAFM-CKFVHYFF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV-VDTTFTLRLPYRGSNsiaHFFC--EA 181
Cdd:cd15098   83 TVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASpVAVHQDLVHHWTASN---QTFCweNW 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242397478 182 PallalASTDTQTSEMAIFLMGvviLLIPVSLILVSYGHIIV---TVVKMKSAAGRFKAFSTCGSHLMVVILF 251
Cdd:cd15098  160 P-----EKQQKPVYVVCTFVFG---YLLPLLLITFCYAKVLNhlhKKLKNMSKKSERSKKKTAQTVLVVVVVF 224

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

26-155

1.14e-04

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 42.89 E-value: 1.14e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15301    2 LIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDY 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILV 155
Cdd:cd15301   82 LASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLL 131

7tmA_GPBAR1

cd15905

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...

27-154

1.20e-04

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.

Pssm-ID: 320571 [Multi-domain] Cd Length: 272 Bit Score: 42.82 E-value: 1.20e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCfsTNIVPQALIHlLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15905    1 IFWLSVPLSSLIIFANLFIILGIACNRKLHNTANYFFLSLLLADLL--TGVALPFIPG-MSNESRRGYHSCLFVYVAPNF 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRvCIQLA-TVSWTSGIL 154
Cdd:cd15905   78 LFLSFLANLLMVHYERYLCIVYPLQYHNFWVHR-WVPLAlLLTWALPLL 125

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

29-156

1.31e-04

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 42.91 E-value: 1.31e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15215    4 VLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFA 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15215   84 FAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQS 131

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

30-157

1.38e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 42.57 E-value: 1.38e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLGIYMV-TVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQAlihllsrkktisfrrCAAQLLLFLIFG 108
Cdd:cd15326    5 LVLGAFILfAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFS---------------ATLEILGYWVFG 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242397478 109 --------------CTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15326   70 rifcdiwaavdvlcCTASILsLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISI 133

7tmA_SREB2_GPR85

cd15218

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...

37-156

1.54e-04

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320346 [Multi-domain] Cd Length: 330 Bit Score: 42.71 E-value: 1.54e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  37 VTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPqALIHLLSRKKTISFRRCAAQLLLFL-IFGCTQCA-L 114
Cdd:cd15218   13 VSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFP-FVFTSVKNGSTWTYGTLTCKVIAFLgVLSCFHTAfM 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 242397478 115 LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15218   92 LFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMA 133

7tmA_TAAR6_8_9

cd15316

trace amine-associated receptors 6, 8, and 9, member of the class A family of ...

26-156

1.75e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320439 [Multi-domain] Cd Length: 290 Bit Score: 42.54 E-value: 1.75e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15316    2 ILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15316   82 SFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYS 132

7tmA_Beta2_AR

cd15957

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...

29-156

2.83e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.

Pssm-ID: 341355 [Multi-domain] Cd Length: 301 Bit Score: 41.77 E-value: 2.83e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15957    5 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCV 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15957   85 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTS 132

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

26-149

2.98e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 41.85 E-value: 2.98e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIhlLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15068    2 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSW 149
Cdd:cd15068   80 VLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW 123

7tmA_D1B_dopamine_R

cd15319

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

115-221

3.11e-04

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320442 [Multi-domain] Cd Length: 317 Bit Score: 41.87 E-value: 3.11e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 115 LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVdttfTLRLPYRGSNSIAHFFCEAPALLALASTDTQT 194
Cdd:cd15319   91 LCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFI----PVQLNWHKDSGDDWVGLHNSSISRQVEENCDS 166

                         90       100
                 ....*....|....*....|....*....
gi 242397478 195 SEMAIFLM--GVVILLIPVSLILVSYGHI 221
Cdd:cd15319  167 SLNRTYAIssSLISFYIPVAIMIVTYTRI 195

7tmA_PAR

cd15162

protease-activated receptors, member of the class A family of seven-transmembrane G ...

25-236

4.07e-04

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.

Pssm-ID: 341328 [Multi-domain] Cd Length: 280 Bit Score: 41.28 E-value: 4.07e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLlsRKKTISFRRCAAQLLLF 104
Cdd:cd15162    1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHI--HGNNWIFGEALCRLVTV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCA--LLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV----VDTTFTLRLPYRGSNSIAHFF 178
Cdd:cd15162   79 AFYGNMYCSilLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLplylVKQTIFLPALDITTCHDVLPE 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242397478 179 CE-----APALLALAstdtqtsemaiflmgVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFK 236
Cdd:cd15162  159 QLlvgdwFYYFLSLA---------------IVGFLIPFILTASCYVATIRTLAALEDENSEKK 206

7tmA_alpha-2D_AR

cd15324

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

26-156

4.83e-04

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320447 [Multi-domain] Cd Length: 256 Bit Score: 41.01 E-value: 4.83e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15324    2 LIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15324   82 LFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVIS 132

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

26-142

5.11e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 40.95 E-value: 5.11e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCA----AQL 101
Cdd:cd15202    2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHfsnfAQY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 242397478 102 LLFLIFGCTqcalLAVMSYDRYVAICNPLHYSSTMTWRVCI 142
Cdd:cd15202   82 CSVHVSAYT----LTAIAVDRYQAIMHPLKPRISKTKAKFI 118

7tmA_TACR_family

cd14992

tachykinin receptor and closely related proteins, member of the class A family of ...

26-292

7.71e-04

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320123 [Multi-domain] Cd Length: 291 Bit Score: 40.49 E-value: 7.71e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAaqLLLFL 105
Cdd:cd14992    2 ILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCK--IVNYL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLA--VMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTlRLPYRGSNSIahffCEAPA 183
Cdd:cd14992   80 RTVSVYASSLTltAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYA-TTEVLFSVKN----QEKIF 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 184 LLALASTDTQTSEMAIFLM-GVVILLIPVSLILVSYGHIIVTVVKMKSAagrfkAFSTCGSHLM--------------VV 248
Cdd:cd14992  155 CCQIPPVDNKTYEKVYFLLiFVVIFVLPLIVMTLAYARISRELWFRKVP-----GFSIKEVERKrlkckrrvikmlvcVV 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 242397478 249 ILF-------YGSGIITYMTPKSSKEQEKLvSVFY-----AMVTPMLNPLIYSLRN 292
Cdd:cd14992  230 VLFvicwlpfHLFFLLRDFFPLIMKEKHTL-QVYYflhwiAMSNSMYNPIIYVTLN 284

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

38-156

8.87e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 40.31 E-value: 8.87e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  38 TVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGCTQCALLAV 117
Cdd:cd15323   14 TIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCA 93

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 242397478 118 MSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15323   94 ISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVIS 132

7tmA_mAChR

cd15049

muscarinic acetylcholine receptor subfamily, member of the class A family of ...

36-155

8.97e-04

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341322 [Multi-domain] Cd Length: 262 Bit Score: 40.38 E-value: 8.97e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  36 MVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCaaQLLLFLIFGCTQCAL- 114
Cdd:cd15049   12 LVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLC--DLWLALDYVASNASVm 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 242397478 115 -LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILV 155
Cdd:cd15049   90 nLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVL 131

7tmA_D3_dopamine_R

cd15310

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...

29-299

9.17e-04

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320436 [Multi-domain] Cd Length: 259 Bit Score: 40.34 E-value: 9.17e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15310    5 LSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMM 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCAL-LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSnsiahffceaPALLAL 187
Cdd:cd15310   85 CTASILnLCAISIDRYTAVVMPVHYQHGTGQSSCRRVSLMITAVWVLAFAVSCPLLFGFNTTGD----------PTVCSI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 188 ASTDTqtsemaIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKAfsTCGSHLMVVILFYGSGIITYMTPKSSKE 267
Cdd:cd15310  155 SNPDF------VIYSSVVSFYLPFGVTLLVYVRIYVVLLREKKATQMLAI--VLGAFIVCWLPFFLTHILNTHCQACHVP 226

                        250       260       270
                 ....*....|....*....|....*....|...
gi 242397478 268 QEKL-VSVFYAMVTPMLNPLIYSLRNKDVKGAL 299
Cdd:cd15310  227 PELYsATTWLGYVNSALNPVIYTTFNIEFRRAF 259

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

26-147

1.07e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 40.02 E-value: 1.07e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGiymVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15053    5 LFLLLLPL---LTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKWYLGPILCDIYIAMD 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 242397478 106 IFGCTQCAL-LAVMSYDRYVAICNPLHYS-STMTWRVCIQLATV 147
Cdd:cd15053   82 VMCSTASIFnLCAISIDRYIAVTQPIKYArQKNSKRVLLTIAIV 125

7tmA_NTSR1

cd15355

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...

26-214

1.12e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320477 [Multi-domain] Cd Length: 310 Bit Score: 40.22 E-value: 1.12e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGN---LFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLL 102
Cdd:cd15355    2 LVTAIYLALFVVGTVGNsitLYTLARKKSLQHLQSTVHYHLASLALSDLLILLLAMPVELYNFIWVHHPWAFGDAACRGY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 103 LFLIFGCTQCALLAV--MSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSvVDTTFTLRLPYRGSNSIAHFFCE 180
Cdd:cd15355   82 YFLRDACTYATALNVasLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLA-IPMLFTMGEQNRSGTHPGGLICT 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 242397478 181 APALLALASTDTQTSEMAIFLMGVVILLIPVSLI 214
Cdd:cd15355  161 PIVDTSTLKVVIQVNAFLSFLFPMLVISVLNTLI 194

7tmA_alpha2A_AR

cd15322

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

26-156

1.21e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320445 [Multi-domain] Cd Length: 259 Bit Score: 39.93 E-value: 1.21e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMV-TVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15322    1 LTLIILVGLLMLlTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVS 156
Cdd:cd15322   81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVIS 132

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

26-229

1.21e-03

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 39.68 E-value: 1.21e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGN-LFLMFLVRaDSRLHTPMYFFLCNLSLADLCFSTNIVPQALIhllsrkktisfrrcaAQLLLF 104
Cdd:cd15206    2 LIIPLYSVIFLLAVVGNiLVIVTLVQ-NKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLV---------------GQLLRN 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 105 LIFGCTQCAL---------------LAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPY- 168
Cdd:cd15206   66 FIFGEVMCKLipyfqavsvsvstftLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMs 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 242397478 169 -RGSNSIAHFFceapallalasTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMK 229
Cdd:cd15206  146 rPGGHKCREVW-----------PNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLLEAK 196

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

26-157

1.29e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 39.72 E-value: 1.29e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTIsFRRCAAQLLLFL 105
Cdd:cd15394    2 LIIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWV-FGRFMCYFVFLM 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 242397478 106 IFGCTQCAL--LAVMSYDRYVAICNPLHysSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15394   81 QPVTVYVSVftLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLSCGLAL 132

7tmA_GPR63

cd15404

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...

34-232

1.64e-03

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320526 [Multi-domain] Cd Length: 265 Bit Score: 39.44 E-value: 1.64e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGCTQCA 113
Cdd:cd15404   10 ILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFWLFVMEGVA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 114 LLAVMSYDRYVAICNPLHYSSTMTWRVCIqlaTVSWTsgilvsvvdTTFTLRLPYRGSNSIAHFFCEAPALLALASTDTQ 193
Cdd:cd15404   90 ILLIISIDRFLIIVQKQDKLNPYRAKVLI---AVSWA---------VSFCVAFPLAVGSPDLQIPSRAPQCVFGYTTNPG 157

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 242397478 194 TSEMAIFLMgVVILLIPVSLILVSYGHIIVTVVKMKSAA 232
Cdd:cd15404  158 YQAYVILIM-LIFFFIPFMVMLYSFMGILNTVRSFKTRA 195

7tmA_GPR6

cd15962

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...

42-299

1.67e-03

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.

Pssm-ID: 320628 [Multi-domain] Cd Length: 268 Bit Score: 39.53 E-value: 1.67e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  42 NLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAaqlLLFLIFGCTQCALLAVmSYD 121
Cdd:cd15962   18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETISLITVG---FLVASFTASVSSLLAI-TVD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 122 RYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVvdttftlrLPYRGSNSIAHFF-CEAPALLALAS-TDTQTSEMAI 199
Cdd:cd15962   94 RYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGL--------LPVLGWNCLEERAsCSIVRPLTKSNvTLLSASFFFI 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 200 FLMgVVILLIPVSLILVSYGHIIvTVVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYMTPKSSKEQEKLVSVFYAMV 279
Cdd:cd15962  166 FIL-MLHLYIKICKIVCRHAHQI-ALQQHFLTASHYVATKKGVSTLAIILGTFGASWLPFAIYCVVGDHEYPAVYTYATL 243

                        250       260
                 ....*....|....*....|....*
gi 242397478 280 TP-----MLNPLIYSLRNKDVKGAL 299
Cdd:cd15962  244 LPatynsMINPIIYAYRNQEIQRSM 268

7tmA_Kappa_opioid_R

cd15091

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...

34-130

2.20e-03

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320219 [Multi-domain] Cd Length: 282 Bit Score: 39.17 E-value: 2.20e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSrkkTISFRRCAAQLLLFLIF--GCTQ 111
Cdd:cd15091   10 VFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMN---SWPFGDVLCKIVISIDYynMFTS 86

                         90
                 ....*....|....*....
gi 242397478 112 CALLAVMSYDRYVAICNPL 130
Cdd:cd15091   87 IFTLTMMSVDRYIAVCHPV 105

7tmA_mAChR_M2

cd15297

muscarinic acetylcholine receptor subtype M2, member of the class A family of ...

26-149

2.40e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320424 [Multi-domain] Cd Length: 262 Bit Score: 38.79 E-value: 2.40e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIY-MVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15297    1 VFIVLVAGSLsLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSW 149
Cdd:cd15297   81 YVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAW 125

7tmA_Mel1C

cd15401

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...

27-229

2.48e-03

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320523 [Multi-domain] Cd Length: 279 Bit Score: 39.12 E-value: 2.48e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15401    3 LAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSgILVSVVDTTFTLRLPYRgsnsiahffceaPALLA 186
Cdd:cd15401   83 SVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVL-TLAAIVPNFFVGSLQYD------------PRIYS 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 242397478 187 LASTDTQTSEMAIFLMgVVILLIPVSLILVSYGHIIVTVVKMK 229
Cdd:cd15401  150 CTFAQTVSSSYTITVV-VVHFIVPLSIVTFCYLRIWVLVIQVK 191

7tmA_5-HT4

cd15056

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...

26-138

2.65e-03

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320184 [Multi-domain] Cd Length: 294 Bit Score: 39.01 E-value: 2.65e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMvTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15056    3 LSTFLSLVILL-TILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDV 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 242397478 106 IFGCTQCALLAVMSYDRYVAIC-NPLHYSSTMTW 138
Cdd:cd15056   82 LLTTASIMHLCCIALDRYYAICcQPLVYKMTPLR 115

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

57-155

2.74e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 38.89 E-value: 2.74e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  57 TPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLlFLIFGCTQCAL-LAVMSYDRYVAICNPLHYSST 135
Cdd:cd15104   33 TKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMC-FVITSCAASVLsLAAIAFDRYLALKQPLRYKQI 111

                         90       100
                 ....*....|....*....|
gi 242397478 136 MTWRVCIQLATVSWTSGILV 155
Cdd:cd15104  112 MTGKSAGALIAGLWLYSGLI 131

7tmA_mAChR_M5

cd15300

muscarinic acetylcholine receptor subtype M5, member of the class A family of ...

34-137

3.02e-03

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320427 [Multi-domain] Cd Length: 262 Bit Score: 38.47 E-value: 3.02e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGCTQCA 113
Cdd:cd15300   10 VSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVM 89

                         90       100
                 ....*....|....*....|....
gi 242397478 114 LLAVMSYDRYVAICNPLHYSSTMT 137
Cdd:cd15300   90 NLLVISFDRYFSITRPLTYRAKRT 113

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

29-154

3.35e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 38.62 E-value: 3.35e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLcFSTNIVPQALIHLLsRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15928    5 AVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPLDLYRLW-RYRPWRFGDLLCRLMYFFSET 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 242397478 109 CTQCALLAV--MSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGIL 154
Cdd:cd15928   83 CTYASILHItaLSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIV 130

7tmA_KiSS1R

cd15095

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...

34-157

3.41e-03

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.

Pssm-ID: 320223 [Multi-domain] Cd Length: 288 Bit Score: 38.42 E-value: 3.41e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVP-QALIHLLSrkkTISFRRCAAQLLLFLIFGCTQ- 111
Cdd:cd15095   10 IFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPfTAALYATP---SWVFGDFMCKFVNYMMQVTVQa 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 242397478 112 -CALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15095   87 tCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSI 133

7tmA_CCR8

cd15187

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...

26-222

3.47e-03

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.

Pssm-ID: 320315 [Multi-domain] Cd Length: 276 Bit Score: 38.63 E-value: 3.47e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQAliHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15187    2 FLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQA--YYLLDQWVFGNAMCKIVSGAYY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAPALL 185
Cdd:cd15187   80 IGFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPGQGNSW 159

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 242397478 186 ALASTdtqtsemaiFLMGVVILLIPVSLILVSYGHII 222
Cdd:cd15187  160 KVFTN---------FEVNILGLLIPFSILIFCYHNIL 187

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

34-158

3.50e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 38.67 E-value: 3.50e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIhlLSRKKTISFRRCAAQLLLFLIFgcTQCA 113
Cdd:cd15071   10 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAII--INIGPQTEFYSCLMVACPVLIL--TQSS 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 242397478 114 LLAVM--SYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVV 158
Cdd:cd15071   86 ILALLaiAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLT 132

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

24-237

3.73e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 38.39 E-value: 3.73e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  24 QKLLFILFLGIY-MVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLL 102
Cdd:cd15299    2 QVVLIAFLTGILaLVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 103 LFLIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRlpYRGSNSIAHFFCEAP 182
Cdd:cd15299   82 IDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQY--FVGKRTVPPDECFIQ 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 242397478 183 ALlalastdtqTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKA 237
Cdd:cd15299  160 FL---------SEPIITFGTAIAAFYLPVTIMTILYWRIYKETIKEKKAAQTLSA 205

7tmA_Retinal_GPR

cd15072

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...

33-297

4.10e-03

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.

Pssm-ID: 320200 [Multi-domain] Cd Length: 260 Bit Score: 38.11 E-value: 4.10e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  33 GIYMVTVLGNLFL----MFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISfRRCAAQLLLFLIFG 108
Cdd:cd15072    5 SILLVEALVGFSLngltILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSLLRRWPYGS-EGCQAHGFQGFFTA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNP--LHYSSTMTWRVCIQLATVSWTSGILV-------SVVDTTFTLRLPYRGSNSIAHFFC 179
Cdd:cd15072   84 LASICSSAAIAWDRYHHYCTRskLQWSTAISLVLFVWLFSAFWAAMPLLgwgeydyEPLGTCCTLDYSKGDRNYVSYLFT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 180 eapallalastdtqtseMAIFLMgvvilLIPVSLILVSYGHIivtVVKMKSaAGRFKAfsTCGSHLMVVILFYGSGIITY 259
Cdd:cd15072  164 -----------------MAFFNF-----ILPLFILLTSYSSI---EQKLKK-EGHLRF--NTGLPLLTLLICWGPYAILA 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 242397478 260 M-------TPKSSKEQekLVSVFYAMVTPMLNPLIYSLRNKDVKG 297
Cdd:cd15072  216 LyaaitdvTSISPKLR--MVPALLAKTSPTINAILYALGNENYRG 258

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

27-237

4.12e-03

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 38.61 E-value: 4.12e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNlFLMFLVRADSRLHTPMYFFLCNLSLADLCFsTNIVPQALIHllSRKKTISFRRCAAQLLLFLI 106
Cdd:PHA03087  43 LIVVYSTIFFFGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDLLF-VMTLPFQIYY--YILFQWSFGEFACKIVSGLY 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALL--AVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWtsgiLVSVVDTtFTLRLPYRGSNSIAHFFCeapal 184
Cdd:PHA03087 119 YIGFYNSMNfiTVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIW----IISIIET-TPILFVYTTKKDHETLIC----- 188

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 242397478 185 LALASTDTQTSEMAI-FLMGVVILLIPVSLILVSYGHIIVTVVKMKSAAGRFKA 237
Cdd:PHA03087 189 CMFYNNKTMNWKLFInFEINIIGMLIPLTILLYCYSKILITLKGINKSKKNKKA 242

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

29-221

4.33e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 38.26 E-value: 4.33e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFG 108
Cdd:cd15979    5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 109 CTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEapalLALA 188
Cdd:cd15979   85 SVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCR----HAWP 160

                        170       180       190
                 ....*....|....*....|....*....|...
gi 242397478 189 STDTQTSEMAIFLMgvVILLIPVSLILVSYGHI 221
Cdd:cd15979  161 SAQVRQAWYVLLLL--ILFFIPGVVMIVAYGLI 191

7tm_GPCRs

cd14964

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

27-137

4.75e-03

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410628 [Multi-domain] Cd Length: 267 Bit Score: 38.18 E-value: 4.75e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd14964    1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYG 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLHYSSTMT 137
Cdd:cd14964   81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSS 111

7tmA_mAChR_M4

cd15298

muscarinic acetylcholine receptor subtype M4, member of the class A family of ...

36-149

4.89e-03

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341344 [Multi-domain] Cd Length: 262 Bit Score: 38.08 E-value: 4.89e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  36 MVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGCTQCALL 115
Cdd:cd15298   12 LVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNL 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 242397478 116 AVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSW 149
Cdd:cd15298   92 LIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAW 125

7tmA_Delta_opioid_R

cd15089

opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...

30-130

5.02e-03

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.

Pssm-ID: 320217 [Multi-domain] Cd Length: 281 Bit Score: 38.01 E-value: 5.02e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  30 LFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLsrkKTISFRRCAAQLLLFLIF-- 107
Cdd:cd15089    6 LYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLM---ETWPFGELLCKAVLSIDYyn 82

                         90       100
                 ....*....|....*....|...
gi 242397478 108 GCTQCALLAVMSYDRYVAICNPL 130
Cdd:cd15089   83 MFTSIFTLTMMSVDRYIAVCHPV 105

7tmA_BRS-3

cd15123

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...

26-227

5.21e-03

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.

Pssm-ID: 320251 [Multi-domain] Cd Length: 294 Bit Score: 37.98 E-value: 5.21e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSrkKTISFRRCAAQLLLFL 105
Cdd:cd15123    2 AIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIA--DTWLFGRIGCKLLSFI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCAL--LAVMSYDRYVAICNPLHY-SSTMTWRVCIQLATVsWTSGILVSVVDTTFTLRLPYRGSNSIAHFFCEAP 182
Cdd:cd15123   80 QLTSVGVSVftLTVLSADRYRAIVKPLELqTSDAVLKTCCKAGCV-WIVSMLFAIPEAVFSDLYSFRDPEKNTTFEACAP 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 242397478 183 allaLASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVK 227
Cdd:cd15123  159 ----YPVSEKILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYK 199

7tmA_NTSR

cd15130

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-157

5.36e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.

Pssm-ID: 320258 [Multi-domain] Cd Length: 281 Bit Score: 38.00 E-value: 5.36e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLV---RADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLL 102
Cdd:cd15130    2 LVTAIYLALFVVGTVGNSVTLFTLarkKSLQSLQSTVRYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGY 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 242397478 103 LFLIFGCTQCALLAV--MSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15130   82 YFLRDACTYATALNVasLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAI 138

7tmA_RNL3R

cd14976

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...

26-251

5.42e-03

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.

Pssm-ID: 320107 [Multi-domain] Cd Length: 290 Bit Score: 37.87 E-value: 5.42e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHT--PMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLL 103
Cdd:cd14976    2 LVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQqsESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 104 FLIFGCTQCALLAVMSYDRYVAICNPL----HYSSTMTWRVCIQLatvsWTSGILVSVVDTTFTLrlpyRGSNSIAHFFC 179
Cdd:cd14976   82 TKLNMYSSIFFLTALSVTRYIAVARALkhgwIRKAFGAFATTIAI----WAAAALAAIPEAIFST----DTWSSVNHTLC 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 242397478 180 EAPALLALASTDTQTSEMAIFLMGVVI-LLIPVSLILVSYGHIIVTVVKMKSAAGRFKAFSTCGSHLMVVILF 251
Cdd:cd14976  154 LLRFPKNSSVTRWYNWLGMYQLQKVVLgFFLPLGIITLSYLLLLRFLQRKRGGSKRRKSRVTKSVFIVVLSFF 226

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

55-299

5.80e-03

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 37.79 E-value: 5.80e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  55 LHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIFGCTQCALLAVMSYDRYVAICNPLHYSS 134
Cdd:cd15073   31 LRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAVDRYLTICRPDLGRK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 135 tMTWRVCIQLATVSWTSGIlvsvvdttFTLRLPYRGsnsiahFFCEAPALLALASTDTQT---SEMAIFLMGVVIL--LI 209
Cdd:cd15073  111 -MTTNTYTVMILLAWTNAF--------FWAAMPLVG------WASYALDPTGATCTINWRkndSSFVSYTMSVIVVnfIV 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 210 PVSLILVSYGHIIVTvVKMKSAAGRFKAFSTCGSHLMVVILFYGSGIITYM---TPKS------SKEQEKLVSVFYAMVT 280
Cdd:cd15073  176 PLAVMFYCYYNVSRF-VKKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLvawSPYSivclwaSFGEPKKIPPWMAIIP 254

                        250       260
                 ....*....|....*....|....*.
gi 242397478 281 PML-------NPLIYSLRNKDVKGAL 299
Cdd:cd15073  255 PLFaksstfyNPCIYVIANKKFRRAI 280

7tmA_GHSR

cd15131

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...

34-149

6.63e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.

Pssm-ID: 320259 [Multi-domain] Cd Length: 291 Bit Score: 37.56 E-value: 6.63e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  34 IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQalIHLLSRKKTISFRRCAAQLLLFLIFGCTQCA 113
Cdd:cd15131   10 LFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLD--LYRLWQYRPWNFGDLLCKLFQFVSESCTYST 87

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 242397478 114 LLAV--MSYDRYVAICNPLHYSSTMTWRVCIQLATVSW 149
Cdd:cd15131   88 ILNItaLSVERYFAICFPLRAKVVVTKRRVKLVILVLW 125

7tmA_OXR

cd15208

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

27-135

6.74e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.

Pssm-ID: 320336 [Multi-domain] Cd Length: 303 Bit Score: 37.75 E-value: 6.74e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  27 LFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSrkKTISFRRCAAQLLLFL- 105
Cdd:cd15208    3 LIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVT--ETWFFGQVLCKIIPYLq 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 242397478 106 -IFGCTQCALLAVMSYDRYVAICNPLHYSST 135
Cdd:cd15208   81 tVSVSVSVLTLSCIALDRWYAICHPLMFKST 111

7tmA_GPR150

cd15198

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...

29-288

8.01e-03

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.

Pssm-ID: 320326 [Multi-domain] Cd Length: 299 Bit Score: 37.48 E-value: 8.01e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLG-IYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALI-HLLSRKKTISFRRCAAQLLLFLI 106
Cdd:cd15198    4 LIFLGvILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIwELLGDRWMAGDVACRLLKLLQAS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 107 FGCTQCALLAVMSYDRYVAICNPLhyssTMTWRVCiQLATVSWTSGILVSVvDTTFTLRLPYRGSNSIA---HFFCEApa 183
Cdd:cd15198   84 ARGASANLVVLLALDRHQAIRAPL----GQPLRAW-KLAALGWLLALLLAL-PQAYVFRVDFPDDPASAwpgHTLCRG-- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 184 llALASTDTQTSEMAIFLMGVVILLIPVSLILVSYGHIIVTVVKMKSAA----------GRFKAFSTCGSHL-------- 245
Cdd:cd15198  156 --IFAPLPRWHLQVYATYEAVVGFVAPVVILGVCYGRLLLKWWERANQApgakkpwkkpSKSHLRATAPSALprakvktl 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 242397478 246 ----MVVILFYGSGI------ITYMTPKSSKEQEKLVSVF--YAMVTPMLNPLIY 288
Cdd:cd15198  234 kmtlVIALLFVGCSLpyfiaeLAAAFGSGDWEPEKVAAALgvMAVANSATNPFVF 288

7tmA_NPR-like_invertebrate

cd15391

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...

26-221

8.31e-03

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.

Pssm-ID: 320513 [Multi-domain] Cd Length: 289 Bit Score: 37.49 E-value: 8.31e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  26 LLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFL 105
Cdd:cd15391    2 HLINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478 106 IFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLatVSWTSGILVSVVDtTFTLRLPYRGSNSIAHFFCEApall 185
Cdd:cd15391   82 VSVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIA--SIWAISFSLSSVQ-LFAGRTQRYGQYSEGRVLCGE---- 154

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 242397478 186 ALASTDTQTSEMAIFLMgVVILLIPVSLILVSYGHI 221
Cdd:cd15391  155 SWPGPDTSRSAYTVFVM-LLTYIIPLLILTSTYGYV 189

7tmA_GPR161

cd15214

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...

28-137

8.39e-03

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320342 [Multi-domain] Cd Length: 261 Bit Score: 37.23 E-value: 8.39e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  28 FILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIVPQALIHLLSRKKTISFRRCAAQLLLFLIF 107
Cdd:cd15214    3 SIAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLI 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 242397478 108 GCTQCALLAVMSYDRYVAICNPLHYSSTMT 137
Cdd:cd15214   83 SSASMLTLGAIAIDRYYAVLYPMVYPMKIT 112

7tmA_Cannabinoid_R

cd15099

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...

37-158

8.82e-03

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320227 [Multi-domain] Cd Length: 281 Bit Score: 37.12 E-value: 8.82e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  37 VTVLGNLFLMFLVRADSRLH-TPMYFFLCNLSLADLCFSTNIVPQALI-HLLSRKKTisfrrcaAQLLLFLIFGCTQCAL 114
Cdd:cd15099   13 VTFLENILVLLTILSSTALRrRPSYLFIGSLALADMLASVIFTISFLDfHVFHQRDS-------RNLFLFKLGGVTMAFT 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 242397478 115 LAVMSY-----DRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSVV 158
Cdd:cd15099   86 ASVGSLlltalDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFL 134

7tmA_V2R

cd15388

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...

29-130

9.37e-03

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320510 [Multi-domain] Cd Length: 295 Bit Score: 37.06 E-value: 9.37e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  29 ILFLGIYMVTV-LGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFST-NIVPQalihlLSRKKTISFR------RCAAQ 100
Cdd:cd15388    4 IAVLAIIFACAlLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFfQVLPQ-----LVWDITDRFRgpdvlcRLVKY 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 242397478 101 LLLFLIFGCTQcaLLAVMSYDRYVAICNPL 130
Cdd:cd15388   79 LQVVGMFASSY--MIVAMTFDRHQAICRPM 106

7tmA_LPAR5

cd15154

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...

25-157

9.80e-03

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.

Pssm-ID: 320282 [Multi-domain] Cd Length: 285 Bit Score: 37.05 E-value: 9.80e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397478  25 KLLFILFLGIYMVTVLGNLFLMFLVRADSRLHTPMYFFLCNLSLADLCFSTNIvPQALIHLLSRKKTISFRRCAAQLLLF 104
Cdd:cd15154    1 TLHLVGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSL-PLRIYYYANHYWPFGNFLCQFSGSIF 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 242397478 105 LIFGCTQCALLAVMSYDRYVAICNPLHYSSTMTWRVCIQLATVSWTSGILVSV 157
Cdd:cd15154   80 QMNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSV 132

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01