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Conserved domains on  [gi|224994257|ref|NP_001139335|]
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zinc finger protein RP23-11F9.3-001 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.79e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 1.79e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 224994257    4 VTYDDVHVNFTREEWALLDSSQKNLYKEVMLETYRNLAAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-453 1.47e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 1.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257  99 AETPYECNQCGKSFARKSHLLRHKRTHTGEKPFQCYQCGKTLARNT----------------HLLQHKKVHTGEKPYECK 162
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplelsrhlrthhnnpsDLNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 163 H-------CDKASVCHIGL----------LYHKRTHAGQRPYEW--------------------NECGKSIVYHSCIKQC 205
Cdd:COG5048  110 LsssssnsNDNNLLSSHSLppssrdpqlpDLLSISNLRNNPLPGnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 206 KRRHTGEKPFECNQCGKSFARKSNLLRHKRIHTGEKPYKCDQCGK------DFASPSSLKCHKRVHTGENPYECKQCGKA 279
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQlspkslLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 280 FARLSILRTHKRTHTG-EKPFECNECGKSFARKSHLLRHKR--IHTGE--KPYKCD--QCGKDLACPNSLQYHKRVHTGE 352
Cdd:COG5048  270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 353 KSYECKQC-------GKAFAFSTSLRIHKRTHTGEKPYEC--NQCGKAFSSPSGFLYHKQTHTGERPYECN--ECGKSFI 421
Cdd:COG5048  350 SPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                        410       420       430
                 ....*....|....*....|....*....|..
gi 224994257 422 HRSNFQMHKRTHTGEKPFECDQCGKSFAQNTY 453
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 1.49e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....*.
gi 224994257  453 YLLQHKRVHTGEKPYECKHCGKAFAY 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.79e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 1.79e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 224994257    4 VTYDDVHVNFTREEWALLDSSQKNLYKEVMLETYRNLAAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 2.08e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 78.79  E-value: 2.08e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994257     4 VTYDDVHVNFTREEWALLDSSQKNLYKEVMLETYRNLAAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.22e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 1.22e-17
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 224994257   4 VTYDDVHVNFTREEWALLDSSQKNLYKEVMLETYRNLA 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-453 1.47e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 1.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257  99 AETPYECNQCGKSFARKSHLLRHKRTHTGEKPFQCYQCGKTLARNT----------------HLLQHKKVHTGEKPYECK 162
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplelsrhlrthhnnpsDLNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 163 H-------CDKASVCHIGL----------LYHKRTHAGQRPYEW--------------------NECGKSIVYHSCIKQC 205
Cdd:COG5048  110 LsssssnsNDNNLLSSHSLppssrdpqlpDLLSISNLRNNPLPGnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 206 KRRHTGEKPFECNQCGKSFARKSNLLRHKRIHTGEKPYKCDQCGK------DFASPSSLKCHKRVHTGENPYECKQCGKA 279
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQlspkslLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 280 FARLSILRTHKRTHTG-EKPFECNECGKSFARKSHLLRHKR--IHTGE--KPYKCD--QCGKDLACPNSLQYHKRVHTGE 352
Cdd:COG5048  270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 353 KSYECKQC-------GKAFAFSTSLRIHKRTHTGEKPYEC--NQCGKAFSSPSGFLYHKQTHTGERPYECN--ECGKSFI 421
Cdd:COG5048  350 SPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                        410       420       430
                 ....*....|....*....|....*....|..
gi 224994257 422 HRSNFQMHKRTHTGEKPFECDQCGKSFAQNTY 453
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-254 1.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.72e-04
                          10        20
                  ....*....|....*....|....*.
gi 224994257  229 NLLRHKRIHTGEKPYKCDQCGKDFAS 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 1.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....*.
gi 224994257  453 YLLQHKRVHTGEKPYECKHCGKAFAY 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.79e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 1.79e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 224994257    4 VTYDDVHVNFTREEWALLDSSQKNLYKEVMLETYRNLAAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 2.08e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 78.79  E-value: 2.08e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 224994257     4 VTYDDVHVNFTREEWALLDSSQKNLYKEVMLETYRNLAAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.22e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 1.22e-17
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 224994257   4 VTYDDVHVNFTREEWALLDSSQKNLYKEVMLETYRNLA 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-453 1.47e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 1.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257  99 AETPYECNQCGKSFARKSHLLRHKRTHTGEKPFQCYQCGKTLARNT----------------HLLQHKKVHTGEKPYECK 162
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplelsrhlrthhnnpsDLNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 163 H-------CDKASVCHIGL----------LYHKRTHAGQRPYEW--------------------NECGKSIVYHSCIKQC 205
Cdd:COG5048  110 LsssssnsNDNNLLSSHSLppssrdpqlpDLLSISNLRNNPLPGnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 206 KRRHTGEKPFECNQCGKSFARKSNLLRHKRIHTGEKPYKCDQCGK------DFASPSSLKCHKRVHTGENPYECKQCGKA 279
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQlspkslLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 280 FARLSILRTHKRTHTG-EKPFECNECGKSFARKSHLLRHKR--IHTGE--KPYKCD--QCGKDLACPNSLQYHKRVHTGE 352
Cdd:COG5048  270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 353 KSYECKQC-------GKAFAFSTSLRIHKRTHTGEKPYEC--NQCGKAFSSPSGFLYHKQTHTGERPYECN--ECGKSFI 421
Cdd:COG5048  350 SPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                        410       420       430
                 ....*....|....*....|....*....|..
gi 224994257 422 HRSNFQMHKRTHTGEKPFECDQCGKSFAQNTY 453
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-491 6.68e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 213 KPFECNQCGKSFARKSNLLRHKRIHTGEKPYKCDQCGKD--FASPSSLKCHKRVHTGENPYECKQ--------------- 275
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 276 -CGKAFARLSILRTHKRTHTGEKPFECNECGKSFARKSHLLRHKRIHTGEK-------PYKCDQCGKDLACPNSLQYHKR 347
Cdd:COG5048  112 sSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 348 VHTGEKSYECKQCGKAFAFSTSLRIHKRTHTGEKPYECNQCGKAFSSPSGFLYHKQTHTgerPYECNECGKSFIHRSNFQ 427
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSASESPRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 428 MHKRTH----------TGEKPFECDQCGKSFAQNTYLLQHKR--VHTGE--KPYECKH--CGKAFAYSNNLRVHIRTHTK 491
Cdd:COG5048  269 SSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-228 1.86e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257  79 QCDKAFAFQSHNQRQER--IHTAE--TPYEC--NQCGKSFARKSHLLRHKRTHTGEKPFQCYQC-------GKTLARNTH 145
Cdd:COG5048  294 QCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQ 373

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 146 LLQHKKVHTGEKPYECKH--CDKASVCHIGLLYHKRTHAGQRPYE--WNECGKSIVYHSCIKQCKRRHTGEKPFECNQCG 221
Cdd:COG5048  374 SLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNckNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK 453


                 ....*..
gi 224994257 222 KSFARKS 228
Cdd:COG5048  454 SFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-254 1.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.72e-04
                          10        20
                  ....*....|....*....|....*.
gi 224994257  229 NLLRHKRIHTGEKPYKCDQCGKDFAS 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-450 3.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.56e-04
                          10        20
                  ....*....|....*....|....*.
gi 224994257  425 NFQMHKRTHTGEKPFECDQCGKSFAQ 450
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-310 4.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.55e-04
                          10        20
                  ....*....|....*....|....*
gi 224994257  286 LRTHKRTHTGEKPFECNECGKSFAR 310
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 323-406 5.49e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 5.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224994257 323 GEKPYKCD--QCGKDLACPNSLQYHKRV-HTGEKSYECKQCGKAFAFSTSlrihkrthtgEKPYECNQCGKAFSSPSGFL 399
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAK----------DKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 224994257 400 YHKqTHT 406
Cdd:COG5189  416 YHR-KHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 9.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.12e-04
                          10        20
                  ....*....|....*....|....*.
gi 224994257  369 SLRIHKRTHTGEKPYECNQCGKAFSS 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 1.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....*.
gi 224994257  453 YLLQHKRVHTGEKPYECKHCGKAFAY 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-334 3.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.27e-03
                          10        20
                  ....*....|....*....|..
gi 224994257  313 HLLRHKRIHTGEKPYKCDQCGK 334
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGK 22
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-365 5.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.35e-03
                          10        20
                  ....*....|....*....|....*
gi 224994257  341 SLQYHKRVHTGEKSYECKQCGKAFA 365
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
117-139 6.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.13e-03
                          10        20
                  ....*....|....*....|...
gi 224994257  117 HLLRHKRTHTGEKPFQCYQCGKT 139
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKS 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 103-125 7.01e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.01e-03
                          10        20
                  ....*....|....*....|...
gi 224994257  103 YECNQCGKSFARKSHLLRHKRTH 125
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 299-321 8.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.87e-03
                          10        20
                  ....*....|....*....|...
gi 224994257  299 FECNECGKSFARKSHLLRHKRIH 321
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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