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Conserved domains on  [gi|224451023|ref|NP_001138931|]
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homeodomain-only protein isoform b [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10052840)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Gene Ontology:  GO:0003677|GO:0006357|GO:0043565
PubMed:  1357790|26464018|21557080

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 10-62 3.78e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 52.25  E-value: 3.78e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 224451023 10 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSE 62
Cdd:cd00086   8 TPEQLEELEKEFEK-NPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 10-62 3.78e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 52.25  E-value: 3.78e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 224451023 10 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSE 62
Cdd:cd00086   8 TPEQLEELEKEFEK-NPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
9-60 5.60e-08

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 44.41  E-value: 5.60e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224451023   9 PTEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRR 60
Cdd:pfam00046  7 FTPEQLEELEKEFQE-NPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 10-59 6.70e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 44.16  E-value: 6.70e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 224451023   10 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWR 59
Cdd:smart00389  9 TPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
10-61 4.06e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 36.26  E-value: 4.06e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224451023  10 TEDQVEILEYNFnKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRS 61
Cdd:COG5576   59 TDEQLMVLEREF-EINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKK 109
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 10-62 3.78e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 52.25  E-value: 3.78e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 224451023 10 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSE 62
Cdd:cd00086   8 TPEQLEELEKEFEK-NPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
9-60 5.60e-08

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 44.41  E-value: 5.60e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224451023   9 PTEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRR 60
Cdd:pfam00046  7 FTPEQLEELEKEFQE-NPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 10-59 6.70e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 44.16  E-value: 6.70e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 224451023   10 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWR 59
Cdd:smart00389  9 TPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
10-61 4.06e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 36.26  E-value: 4.06e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224451023  10 TEDQVEILEYNFnKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRS 61
Cdd:COG5576   59 TDEQLMVLEREF-EINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKK 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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