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Conserved domains on  [gi|218505694|ref|NP_001136202|]
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BTB/POZ domain-containing protein KCTD1 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BTB_POZ_KCTD1 cd18387
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
636-740 2.98e-67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.


:

Pssm-ID: 349695  Cd Length: 105  Bit Score: 218.72  E-value: 2.98e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 636 SNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTL 715
Cdd:cd18387    1 SNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYSL 80
                         90       100
                 ....*....|....*....|....*
gi 218505694 716 LYEEAKYFQLQPMLLEMERWKQDRE 740
Cdd:cd18387   81 LYEEAKYFQLQPMLLELERWKQDRE 105
DUF3504 super family cl48127
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
284-440 8.83e-07

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


The actual alignment was detected with superfamily member pfam12012:

Pssm-ID: 463430  Cd Length: 162  Bit Score: 49.57  E-value: 8.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694  284 ITRADLRKLYTSSVFSTNTPFGLLNKVWFETCMYFCTRGRENQRELEEDSFGLAMDEDGR-KFVYFKslgpYHKSRSSSW 362
Cdd:pfam12012   2 FSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKPNPReKSTYLR----YYEPPDQVE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694  363 SKKRAESSDEENL-PRMYE--TGTEFCPYASFVKYLSKRNPLCK----AFFQRPRDHCSEGDVTWYENKAIGKNLLGtrm 435
Cdd:pfam12012  78 TGGRKKRDEGVNKvVEQHEnsENPLRCPVKLYEFYLSKCPESVKqrkdVFYLQPEPSCVPDSPLWYSSQPLGRNTLE--- 154

                  ....*
gi 218505694  436 QMLSK 440
Cdd:pfam12012 155 SMLTR 159
H1_KCTD12-like super family cl41727
H1 domain found in potassium channel tetramerization domain-containing proteins; The H1 domain ...
762-845 9.74e-03

H1 domain found in potassium channel tetramerization domain-containing proteins; The H1 domain is found in potassium channel tetramerization domain-containing proteins such as KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), KCTD12b, and KCTD16. They serve as auxiliary gamma-aminobutyric acid type B (GABA-B) receptor subunits that constitute receptor subtypes with distinct functional properties. KCTD12 and -12b generate desensitizing receptor responses while KCTD8 and -16 generate largely non-desensitizing receptor responses. They control GABA-B signaling and regulate the rise time and duration of G protein-coupled inwardly rectifying potassium (GIRK) currents, as well as enhance receptor expression levels. KCTD12 regulates agonist potency and kinetics of GABA-B receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. Members of this family consist of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits and is responsible for desensitization. This model corresponds to the H1 domain.


The actual alignment was detected with superfamily member cd22204:

Pssm-ID: 425358  Cd Length: 118  Bit Score: 36.80  E-value: 9.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 762 RITLSGDKSLIEEVFpeiGDVMCNSVNAGWNHDSTHVIRFPLNgYCHLNsvQVLERLQQRGFEIVGSCGGGVDS------ 835
Cdd:cd22204   29 RILVCGKVSLCREVF---GDTLNESRDPDRGEPDRYTSRFFLK-HNYLE--QAFDQLAEAGFRLVASCGSGTSGlpsagd 102
                         90
                 ....*....|....*.
gi 218505694 836 ------SQFSEYVLRR 845
Cdd:cd22204  103 seekrwNHYTEFVFVR 118
 
Name Accession Description Interval E-value
BTB_POZ_KCTD1 cd18387
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
636-740 2.98e-67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.


Pssm-ID: 349695  Cd Length: 105  Bit Score: 218.72  E-value: 2.98e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 636 SNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTL 715
Cdd:cd18387    1 SNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYSL 80
                         90       100
                 ....*....|....*....|....*
gi 218505694 716 LYEEAKYFQLQPMLLEMERWKQDRE 740
Cdd:cd18387   81 LYEEAKYFQLQPMLLELERWKQDRE 105
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
640-732 9.06e-16

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 73.39  E-value: 9.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694  640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDgTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTS-KLLIPDDfKDYTLLYE 718
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLE-LECDDYDDDTNEYFFDRSPKHFETILNFYRTGgKLHRPEE-VCLDEFLE 78
                          90
                  ....*....|....
gi 218505694  719 EAKYFQLQPMLLEM 732
Cdd:pfam02214  79 EAEFYGLDELALEL 92
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
640-735 2.98e-10

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 57.70  E-value: 2.98e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694   640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPivlDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDfkDYTLLYEE 719
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKE---SDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE--NVEELLEL 76
                           90
                   ....*....|....*.
gi 218505694   720 AKYFQLQPMLLEMERW 735
Cdd:smart00225  77 ADYLQIPGLVELCEEF 92
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
284-440 8.83e-07

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


Pssm-ID: 463430  Cd Length: 162  Bit Score: 49.57  E-value: 8.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694  284 ITRADLRKLYTSSVFSTNTPFGLLNKVWFETCMYFCTRGRENQRELEEDSFGLAMDEDGR-KFVYFKslgpYHKSRSSSW 362
Cdd:pfam12012   2 FSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKPNPReKSTYLR----YYEPPDQVE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694  363 SKKRAESSDEENL-PRMYE--TGTEFCPYASFVKYLSKRNPLCK----AFFQRPRDHCSEGDVTWYENKAIGKNLLGtrm 435
Cdd:pfam12012  78 TGGRKKRDEGVNKvVEQHEnsENPLRCPVKLYEFYLSKCPESVKqrkdVFYLQPEPSCVPDSPLWYSSQPLGRNTLE--- 154

                  ....*
gi 218505694  436 QMLSK 440
Cdd:pfam12012 155 SMLTR 159
H1_KCTD12-like cd22204
H1 domain found in potassium channel tetramerization domain-containing proteins; The H1 domain ...
762-845 9.74e-03

H1 domain found in potassium channel tetramerization domain-containing proteins; The H1 domain is found in potassium channel tetramerization domain-containing proteins such as KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), KCTD12b, and KCTD16. They serve as auxiliary gamma-aminobutyric acid type B (GABA-B) receptor subunits that constitute receptor subtypes with distinct functional properties. KCTD12 and -12b generate desensitizing receptor responses while KCTD8 and -16 generate largely non-desensitizing receptor responses. They control GABA-B signaling and regulate the rise time and duration of G protein-coupled inwardly rectifying potassium (GIRK) currents, as well as enhance receptor expression levels. KCTD12 regulates agonist potency and kinetics of GABA-B receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. Members of this family consist of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits and is responsible for desensitization. This model corresponds to the H1 domain.


Pssm-ID: 409026  Cd Length: 118  Bit Score: 36.80  E-value: 9.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 762 RITLSGDKSLIEEVFpeiGDVMCNSVNAGWNHDSTHVIRFPLNgYCHLNsvQVLERLQQRGFEIVGSCGGGVDS------ 835
Cdd:cd22204   29 RILVCGKVSLCREVF---GDTLNESRDPDRGEPDRYTSRFFLK-HNYLE--QAFDQLAEAGFRLVASCGSGTSGlpsagd 102
                         90
                 ....*....|....*.
gi 218505694 836 ------SQFSEYVLRR 845
Cdd:cd22204  103 seekrwNHYTEFVFVR 118
 
Name Accession Description Interval E-value
BTB_POZ_KCTD1 cd18387
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
636-740 2.98e-67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.


Pssm-ID: 349695  Cd Length: 105  Bit Score: 218.72  E-value: 2.98e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 636 SNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTL 715
Cdd:cd18387    1 SNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYSL 80
                         90       100
                 ....*....|....*....|....*
gi 218505694 716 LYEEAKYFQLQPMLLEMERWKQDRE 740
Cdd:cd18387   81 LYEEAKYFQLQPMLLELERWKQDRE 105
BTB_POZ_KCTD1-like cd18361
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-733 1.06e-62

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.


Pssm-ID: 349670  Cd Length: 94  Bit Score: 205.69  E-value: 1.06e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEE 719
Cdd:cd18361    1 VHIDVGGHIYTSSLETLTKYPESRLGKLFNGSIPIVLDSLKQHYFIDRDGKMFRHILNFLRTSKLLLPDDFTEFDLLYEE 80
                         90
                 ....*....|....
gi 218505694 720 AKYFQLQPMLLEME 733
Cdd:cd18361   81 ARYYELQPMVKQLE 94
BTB_POZ_KCTD15 cd18388
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
637-735 4.30e-59

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.


Pssm-ID: 349696  Cd Length: 99  Bit Score: 195.98  E-value: 4.30e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 637 NAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLL 716
Cdd:cd18388    1 NAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFNLL 80
                         90
                 ....*....|....*....
gi 218505694 717 YEEAKYFQLQPMLLEMERW 735
Cdd:cd18388   81 YEEAKYYQLQPMVKELERW 99
BTB_POZ_KCTD6_like cd18365
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
638-729 1.36e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349674 [Multi-domain]  Cd Length: 94  Bit Score: 127.13  E-value: 1.36e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 638 APVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLY 717
Cdd:cd18365    1 DIVNLNVGGVHYTTTLATLTRFPDSMLGAMFSGSMPTTRDD-QGNYFIDRDGTLFRYILNFLRSSQLSLPEDFKEYDLLL 79
                         90
                 ....*....|..
gi 218505694 718 EEAKYFQLQPML 729
Cdd:cd18365   80 READFYQIEPLI 91
BTB_POZ_KCTD6 cd18394
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
639-729 1.21e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349702 [Multi-domain]  Cd Length: 104  Bit Score: 124.68  E-value: 1.21e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 639 PVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYE 718
Cdd:cd18394    4 PVTLNVGGHLYTTSLSTLTRYPDSMLGAMFRGDFPTARDS-QGNYFIDRDGPLFRYILNFLRTSELTLPVDFKEFDLLRK 82
                         90
                 ....*....|.
gi 218505694 719 EAKYFQLQPML 729
Cdd:cd18394   83 EADFYQIEPLI 93
BTB_POZ_KCTD21 cd18395
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
639-733 1.21e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349703 [Multi-domain]  Cd Length: 98  Bit Score: 121.59  E-value: 1.21e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 639 PVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYE 718
Cdd:cd18395    2 PITLNVGGKLYTTSLATLTRYPDSMLGAMFSGKFPTKKDS-QGNCFIDRDGKIFRYILNFLRTSHLDLPEDFQEMGLLKR 80
                         90
                 ....*....|....*
gi 218505694 719 EAKYFQLQPMLLEME 733
Cdd:cd18395   81 EADFYQIQPLIEALQ 95
BTB_POZ_KCTD-like cd18316
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-723 1.32e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349625  Cd Length: 83  Bit Score: 120.74  E-value: 1.32e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEE 719
Cdd:cd18316    1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGRWPLPRDE-DGSIFIDRDPELFRHILNFLRTGKLPLPSDFVELEELLAE 79

                 ....
gi 218505694 720 AKYF 723
Cdd:cd18316   80 AEFY 83
BTB_POZ_KCTD4 cd18364
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-725 6.25e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349673 [Multi-domain]  Cd Length: 86  Bit Score: 113.24  E-value: 6.25e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEE 719
Cdd:cd18364    2 VTLNVGGYLYITQRQTLTKYPDSFLEGMVNGKIQCTVDA-DGNYFIDRDGLLFRHVLNFLRNGELLLPEGFQENQLLALE 80

                 ....*.
gi 218505694 720 AKYFQL 725
Cdd:cd18364   81 ADFYQL 86
BTB_POZ_KCTD8-like cd18367
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-729 6.34e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349676  Cd Length: 100  Bit Score: 105.45  E-value: 6.34e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEP--IVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLY 717
Cdd:cd18367    5 VELNVGGQVYTTSLSTLIKDPDSLLGRMFSGKNRqeLARDS-KGRYFLDRDGVLFRYILDYLRNQKLVLPENFPERERLK 83
                         90
                 ....*....|..
gi 218505694 718 EEAKYFQLQPML 729
Cdd:cd18367   84 REAEYFQLPELV 95
BTB_POZ_FIP2-like cd18376
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-727 6.93e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349685  Cd Length: 89  Bit Score: 99.24  E-value: 6.93e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIP-DDFKDYTLLYE 718
Cdd:cd18376    1 VKLNVGGQKFTTTLDTLTKDPDSMLAAMFSGRHSLKKDE-DGSYFIDRDGTHFRHILNYLRDGEVKIPtEDRSVLKELLE 79

                 ....*....
gi 218505694 719 EAKYFQLQP 727
Cdd:cd18376   80 EAEYYQLRG 88
BTB_POZ_KCNRG cd18375
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-734 6.91e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349684  Cd Length: 97  Bit Score: 96.72  E-value: 6.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPiVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEE 719
Cdd:cd18375    3 VTLNVGGKKFTTRPSTLRRFPDSRLARMLDGKDQ-DFKVVNGQFFVDRDGSLFSYILDYLRTGQLTLPTEFSDYNRLARE 81
                         90
                 ....*....|....*
gi 218505694 720 AKYFQLQPMLLEMER 734
Cdd:cd18375   82 AEFYGLYSLADLLSQ 96
BTB_POZ_KCTD11 cd18370
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-724 1.96e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.


Pssm-ID: 349679  Cd Length: 88  Bit Score: 89.29  E-value: 1.96e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQ---HYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLL 716
Cdd:cd18370    1 VTLNVGGTLYSTTLETLTRFPDSMLGAMFRAGTPIPPNLNMQgggHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALL 80

                 ....*...
gi 218505694 717 YEEAKYFQ 724
Cdd:cd18370   81 RAEADFYQ 88
BTB_POZ_KCTD14 cd18371
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-733 1.02e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349680  Cd Length: 99  Bit Score: 87.50  E-value: 1.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKL---LIPDdfkdytlL 716
Cdd:cd18371    4 VSLNVGGHIYTTTLSTLRKFPGSKLAELFNGQPKLRTDS-EGRYFIDRDGTYFRYILEYLRTNQVptqHIQE-------V 75
                         90
                 ....*....|....*..
gi 218505694 717 YEEAKYFQLQPMLLEME 733
Cdd:cd18371   76 YKEALFYDIEPLVKLLE 92
BTB_POZ_KCTD7 cd18366
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-729 4.53e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349675  Cd Length: 92  Bit Score: 82.74  E-value: 4.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDytlLYEE 719
Cdd:cd18366    6 VPLNVGGMHFTTRLSTLRKYEDSMLAAMFSGRHHIPKDS-EGRYFIDRDGSYFGYILNFLRDGDLPPRERARA---VYKE 81
                         90
                 ....*....|
gi 218505694 720 AKYFQLQPML 729
Cdd:cd18366   82 AQYYGIGPLI 91
BTB_POZ_KCTD16 cd18398
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-732 3.42e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349706 [Multi-domain]  Cd Length: 103  Bit Score: 80.73  E-value: 3.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLF----DGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTL 715
Cdd:cd18398    5 VELNVGGQVYFTRHATLVSIPHSLLWKMFspkrDTANDLAKDS-KGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKGR 83
                         90
                 ....*....|....*..
gi 218505694 716 LYEEAKYFQLqPMLLEM 732
Cdd:cd18398   84 LKREAEYFQL-PDLVKL 99
BTB_POZ_KCTD12_Pfetin cd18397
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-728 2.20e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12); KCTD12, also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349705 [Multi-domain]  Cd Length: 100  Bit Score: 78.00  E-value: 2.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVL--DSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLY 717
Cdd:cd18397    5 VELNVGGQVYVTRHTTLVSVPDSLLWHMFSQQKPGELarDS-KGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQ 83
                         90
                 ....*....|.
gi 218505694 718 EEAKYFQLQPM 728
Cdd:cd18397   84 REAEFFQLPEL 94
BTB2_POZ_KCTD19 cd18374
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
640-731 2.73e-17

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19); KCTD19 is a BTB/POZ domain-containing protein with unclear biological function. It may be a host factor involved in Nef-induced downregulation of MHC-I. Nef is a HIV-1-encoded protein that plays a key role in the development of AIDS. KCTD19 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349683  Cd Length: 99  Bit Score: 77.93  E-value: 2.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPEsrigrLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEE 719
Cdd:cd18374    3 VKVYVGSHWYATYLKTLLKYPE-----LLSNSKKVRWITYGQTLLISGDGQMFRHILNFLRLGKLLLPSEFKEWPLLCQE 77
                         90
                 ....*....|..
gi 218505694 720 AKYFQLqPMLLE 731
Cdd:cd18374   78 VEEYQI-PALSE 88
BTB_POZ_KCTD8 cd18396
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-729 3.39e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349704 [Multi-domain]  Cd Length: 103  Bit Score: 74.84  E-value: 3.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVL--DSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLY 717
Cdd:cd18396    6 VELNVGGQVYVTKHSTLLSVPDSTLASMFSRRAARELprDN-RGRFFIDRDGFLFRYVLDYLRDKQLALPDHFPEKERLL 84
                         90
                 ....*....|..
gi 218505694 718 EEAKYFQLQPML 729
Cdd:cd18396   85 REAEYFQLGDLV 96
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
640-732 9.06e-16

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 73.39  E-value: 9.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694  640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDgTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTS-KLLIPDDfKDYTLLYE 718
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLE-LECDDYDDDTNEYFFDRSPKHFETILNFYRTGgKLHRPEE-VCLDEFLE 78
                          90
                  ....*....|....
gi 218505694  719 EAKYFQLQPMLLEM 732
Cdd:pfam02214  79 EAEFYGLDELALEL 92
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-722 2.03e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


Pssm-ID: 349626  Cd Length: 82  Bit Score: 66.09  E-value: 2.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEpiVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKdYTLLYEE 719
Cdd:cd18317    1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESH--AYDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVC-PASFKEE 77

                 ...
gi 218505694 720 AKY 722
Cdd:cd18317   78 LEF 80
BTB_POZ_KCTD9 cd18368
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-733 6.22e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.


Pssm-ID: 349677 [Multi-domain]  Cd Length: 100  Bit Score: 65.36  E-value: 6.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKY-PESRIGRLF--DGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIpDDFKDYTLL 716
Cdd:cd18368    3 IKLNVGGRIFTTTRSTLVKKePDSMLARMFsdDSTWPSSRDE-NGAYLIDRSPEYFEPILNYLRHGQLIL-NDGLNPLGV 80
                         90
                 ....*....|....*..
gi 218505694 717 YEEAKYFQLQPMLLEME 733
Cdd:cd18368   81 LEEAKFFGIQSLIEILE 97
BTB_POZ_Kv_KCTD cd18187
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-723 9.75e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349498  Cd Length: 83  Bit Score: 64.42  E-value: 9.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLyEE 719
Cdd:cd18187    1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPGREFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISIPDLR-EE 79

                 ....
gi 218505694 720 AKYF 723
Cdd:cd18187   80 CDFY 83
BTB_POZ_KCNV1 cd18424
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
642-718 1.17e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349731  Cd Length: 109  Bit Score: 62.14  E-value: 1.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 642 IDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVL------DSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTL 715
Cdd:cd18424    3 INVGGSRFVLSQQVLSSHPETRLGKLAVSVRDSVLelcddaNFVDNEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAISF 82

                 ...
gi 218505694 716 LYE 718
Cdd:cd18424   83 LQE 85
BTB_POZ_KCNV2 cd18425
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-723 3.96e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349732  Cd Length: 108  Bit Score: 60.55  E-value: 3.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPI----VLDSLKQH---YFIDRDGQMFRYILNFLRTSKLLIPDDFKD 712
Cdd:cd18425    1 LNINVGGTSYQISYRVAASYPKTRIGRLATYTDRSrkldLCDDYNVQndeYFFDRDPAVFHHIYNFYRTGVLWVKDELCP 80
                         90
                 ....*....|.
gi 218505694 713 YTLLyEEAKYF 723
Cdd:cd18425   81 RNFL-EEINYW 90
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
640-735 2.98e-10

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 57.70  E-value: 2.98e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694   640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPivlDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDfkDYTLLYEE 719
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKE---SDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE--NVEELLEL 76
                           90
                   ....*....|....*.
gi 218505694   720 AKYFQLQPMLLEMERW 735
Cdd:smart00225  77 ADYLQIPGLVELCEEF 92
BTB_POZ_KCTD3-like cd18363
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-723 3.08e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349672  Cd Length: 86  Bit Score: 57.38  E-value: 3.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTepivLDSLKQHY---FIDRDGQMFRYILNFLRTSKLLIPDdfKDYTLL 716
Cdd:cd18363    4 INLNVGGKRFSTSRQTLTWIPDSFFTSLLSGR----ISSLKDETgaiFIDRDPKLFSIILNYLRTKEIDLRN--VDISSL 77

                 ....*..
gi 218505694 717 YEEAKYF 723
Cdd:cd18363   78 RHEAEFY 84
BTB_POZ_SHKBP1 cd18393
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-733 3.73e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349701  Cd Length: 103  Bit Score: 57.64  E-value: 3.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQhYFIDRDGQMFRYILNFLRTSKLLIPDdfKDYTLLYEE 719
Cdd:cd18393    4 IHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDETGA-IFIDRDPTVFAPILNFLRTKELDPRG--IHVSLLLHE 80
                         90
                 ....*....|....
gi 218505694 720 AKYFQLQPMLLEME 733
Cdd:cd18393   81 AQFYGITPLVRRLQ 94
BTB_POZ_KCTD10-like_BACURD cd18369
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-726 4.01e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.


Pssm-ID: 349678 [Multi-domain]  Cd Length: 91  Bit Score: 57.02  E-value: 4.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYpESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEE 719
Cdd:cd18369    1 VKLNVGGSLHYTTIGTLTKQ-DTMLRAMFSGRMEVLTDS-EGWILIDRCGKHFGTILNYLRDGSVPLPESRRELAELLAE 78

                 ....*..
gi 218505694 720 AKYFQLQ 726
Cdd:cd18369   79 AKYYLVQ 85
BTB_POZ_KCTD13_BACURD1 cd18400
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-729 1.04e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 13 (KCTD13); KCTD13, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (BACURD1), or TNFAIP1-like protein, is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD13 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.


Pssm-ID: 349708  Cd Length: 103  Bit Score: 56.48  E-value: 1.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKyPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEE 719
Cdd:cd18400    4 VKLNVGGSLHYTTVQTLTK-QDTMLKAMFSGRVEVLTDS-EGWVLIDRSGRHFGTILNYLRDGSVPLPESTRELEELLGE 81
                         90
                 ....*....|
gi 218505694 720 AKYFQLQPML 729
Cdd:cd18400   82 ARYYLVQGLV 91
BTB_POZ_KCTD18 cd18372
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-723 1.17e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18); KCTD18 is a BTB/POZ domain-containing protein with with unknown biological function. A duplication of the KCTD18 gene has been found in a patient with epilepsy, developmental delay, and autistic behavior, which may contribute to the phenotype. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349681  Cd Length: 101  Bit Score: 56.35  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRtSKLLIPDDFKDYTLLYEE 719
Cdd:cd18372    3 LRLNVGGCIYTARRESLCRFKDSMLSSMFSGRFPLKLDE-SGACVIDRDGRLFKYLLDYLH-GELQIPEDEQTRLALQEE 80

                 ....
gi 218505694 720 AKYF 723
Cdd:cd18372   81 ADYF 84
BTB1_POZ_KCTD19 cd18373
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
641-740 1.68e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 19 (KCTD19); KCTD19 is a BTB/POZ domain-containing protein with unclear biological function. It may be a host factor involved in Nef-induced downregulation of MHC-I. Nef is a HIV-1-encoded protein that plays a key role in the development of AIDS. KCTD19 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349682  Cd Length: 98  Bit Score: 55.56  E-value: 1.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 641 HIDVGGHMYTSSLATLTKYPESRIGRlfdgtEPIVLD-SLKQHYFIDRDGQMFRYILNFLRTSKLLIpDDFKDYTLLYEE 719
Cdd:cd18373    2 YFNVGGWIFSVPKSKLAQFPDSLLWK-----EASSLSeSENTRLFIDRDGFTFRHVHYYLQTSKLSS-SSCSELNLLYEQ 75
                         90       100
                 ....*....|....*....|.
gi 218505694 720 AKYFQLQPMLLEMERWKQDRE 740
Cdd:cd18373   76 AAGLQLTSLLQALDNLKEGKH 96
BTB_POZ_Kv4_KCND cd18380
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
642-727 1.88e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349689 [Multi-domain]  Cd Length: 102  Bit Score: 55.45  E-value: 1.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 642 IDVGGHMYTSSLATLTKYPESRIGrlfdGTE-PIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDfKDYTLLYEEA 720
Cdd:cd18380    4 INVSGRRFETWKNTLEKYPDTLLG----STEkEFFYDDDTKEYFFDRDPEIFRHILNFYRTGKLHYPRH-ECISAYDDEL 78

                 ....*..
gi 218505694 721 KYFQLQP 727
Cdd:cd18380   79 AFFGILP 85
BTB_POZ_KCTD10_BACURD3 cd18399
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
634-741 2.46e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 10 (KCTD10); KCTD10, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (BACURD3), is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. Furthermore, KCTD10 may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD10 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.


Pssm-ID: 349707  Cd Length: 110  Bit Score: 55.46  E-value: 2.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 634 TKSNAPVHIDVGGHMYTSSLATLTKyPESRIGRLFDGTEPIVLDSlKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDY 713
Cdd:cd18399    3 SPSSKYVKLNVGGALYYTTMQTLTK-QDTMLKAMFSGRMEVLTDS-EGWILIDRCGKHFGTILNYLRDGAVPLPESRREI 80
                         90       100
                 ....*....|....*....|....*...
gi 218505694 714 TLLYEEAKYFQLQPMLLEMERWKQDRET 741
Cdd:cd18399   81 EELLAEAKYYLVQGLVEECQAALQNKDT 108
BTB_POZ_KCND1 cd18417
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
621-707 3.14e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349724 [Multi-domain]  Cd Length: 138  Bit Score: 56.11  E-value: 3.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 621 PLNNQGIPTPA--QLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGrlfDGTEPIVLDSLKQHYFIDRDGQMFRYILNF 698
Cdd:cd18417   16 PLAKKPMPKPPsdKKRRNDEILVVNVSGRRFQTWKNTLDRYPDTLLG---SSEKEFFYNEDTQEYFFDRDPEMFRHILNF 92

                 ....*....
gi 218505694 699 LRTSKLLIP 707
Cdd:cd18417   93 YRTGRLHYP 101
BTB_POZ_KCNS1 cd18426
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-731 3.89e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349733 [Multi-domain]  Cd Length: 106  Bit Score: 54.90  E-value: 3.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLF--DGTEPIV-----LDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKD 712
Cdd:cd18426    1 ININVGGLKRRLSSSTLSKFPDTRLGRLLscDSEESILqicddYDVSAKEFYFDRNPGLFPYVLHFYQTGKLHIMEELCV 80
                         90
                 ....*....|....*....
gi 218505694 713 YTlLYEEAKYFQLQPMLLE 731
Cdd:cd18426   81 FS-FSQEIEYWGINEFFLD 98
BTB_POZ_KCTD2-like cd18362
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-723 4.80e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.


Pssm-ID: 349671 [Multi-domain]  Cd Length: 85  Bit Score: 53.91  E-value: 4.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPivLDSLKQH---YFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLL 716
Cdd:cd18362    2 VKLNVGGTYFLTTRTTLCRDPKSFLCRLCQEDPD--LPSDKDEtgaYLIDRDPTYFGPILNYLRHGKLIIDKDLAEEGVL 79

                 ....*..
gi 218505694 717 yEEAKYF 723
Cdd:cd18362   80 -EEAEFY 85
BTB_POZ_Kv3_KCNC cd18379
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-709 2.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349688 [Multi-domain]  Cd Length: 109  Bit Score: 52.78  E-value: 2.04e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIV-LDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDD 709
Cdd:cd18379    1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEASAFdYDPVTGEFFFDRHPGVFAQILNYYRTGKLHCPAD 71
BTB_POZ_KCTD3 cd18392
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-727 2.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349700  Cd Length: 88  Bit Score: 52.18  E-value: 2.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTepivLDSLKQH---YFIDRDGQMFRYILNFLRTSKLLIpdDFKDYTLL 716
Cdd:cd18392    4 IQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGR----ISSLKDEtgaIFIDRDPTAFVPILNFLRTKELDL--RGVNINVL 77
                         90
                 ....*....|.
gi 218505694 717 YEEAKYFQLQP 727
Cdd:cd18392   78 RHEAEFYGITP 88
BTB_POZ_TNFAIP1_BACURD2 cd18401
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
637-740 2.37e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.


Pssm-ID: 349709  Cd Length: 104  Bit Score: 52.58  E-value: 2.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 637 NAPVHIDVGGHMYTSSLATLTKYpESRIGRLFDGTEPIVLDslKQHY-FIDRDGQMFRYILNFLRTSKLLIPDDFKDYTL 715
Cdd:cd18401    2 NKYVRLNVGGSLYYTTVQVLTRH-DTMLKAMFSGRMEVLTD--KEGWiLIDRCGKHFGTILNYLRDDTVALPKSRQEIKE 78
                         90       100
                 ....*....|....*....|....*
gi 218505694 716 LYEEAKYFQLQPMLLEMERWKQDRE 740
Cdd:cd18401   79 LMAEAKYYLIQGLVDMCQAALQDKK 103
BTB_POZ_KCTD2 cd18389
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-740 4.25e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.


Pssm-ID: 349697 [Multi-domain]  Cd Length: 105  Bit Score: 51.91  E-value: 4.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDgtEPIVLDSLKQH---YFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLL 716
Cdd:cd18389    3 VRLNVGGTYFVSTKQTLCRDPKSFLYRLCQ--EDPDLDSDKDEtgaYLIDRDPTYFGPILNYLRHGKLIINKELAEEGVL 80
                         90       100
                 ....*....|....*....|....
gi 218505694 717 yEEAKYFQLQPMLLEMERWKQDRE 740
Cdd:cd18389   81 -EEAEFYNIASLVRLVKERIRDNE 103
BTB_POZ_Kv2_KCNB cd18378
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-709 6.74e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349687 [Multi-domain]  Cd Length: 109  Bit Score: 51.24  E-value: 6.74e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGT--EPIV-----LDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDD 709
Cdd:cd18378    4 VLLNVGGVRHEVLWRTLDRLPRTRLGRLRECNthESLLelcddYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEE 80
BTB_POZ_KCTD17 cd18391
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-729 8.51e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.


Pssm-ID: 349699  Cd Length: 101  Bit Score: 50.76  E-value: 8.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLyEE 719
Cdd:cd18391    3 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVL-EE 81
                         90
                 ....*....|
gi 218505694 720 AKYFQLQPML 729
Cdd:cd18391   82 AEFYNIGPLI 91
BTB_POZ_Shal-like cd18420
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
621-727 1.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349727 [Multi-domain]  Cd Length: 139  Bit Score: 51.77  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 621 PLNNQGIPTPAQLTKSNAP----VHIDVGGHMYTSSLATLTKYPESRIGrlfDGTEPIVLDSLKQHYFIDRDGQMFRYIL 696
Cdd:cd18420   15 PIANNPLPPPPVDQERRRTddekLIINVSGRRFETWRNTLEKYPDTLLG---SNEREFFYDEETKEYFFDRDPDIFRHIL 91
                         90       100       110
                 ....*....|....*....|....*....|.
gi 218505694 697 NFLRTSKLLIPDDfKDYTLLYEEAKYFQLQP 727
Cdd:cd18420   92 NYYRTGKLHYPKH-ECLTAYDEELAFFGIMP 121
BTB_Shaw-like cd18416
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-737 1.61e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349723 [Multi-domain]  Cd Length: 112  Bit Score: 50.35  E-value: 1.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLfdgTEPIV-LDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDyTLLYE 718
Cdd:cd18416    4 VVLNVGGIRHETYKATLKKIPATRLSRL---TEALAnYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTDVCG-PLFEE 79
                         90
                 ....*....|....*....
gi 218505694 719 EAKYFQLQPMLLEMERWKQ 737
Cdd:cd18416   80 ELEFWGLDANQVEPCCWMT 98
BTB_POZ_KCND3 cd18419
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
621-730 6.07e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349726 [Multi-domain]  Cd Length: 138  Bit Score: 49.59  E-value: 6.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 621 PLNNQGIP-TPAQLTKSNAPVHI-DVGGHMYTSSLATLTKYPESRIGRlfdGTEPIVLDSLKQHYFIDRDGQMFRYILNF 698
Cdd:cd18419   16 PVANCPMPlAPADKNKRQDELIVlNVSGRRFQTWRTTLERYPDTLLGS---TEKEFFFNEDTKEYFFDRDPEVFRCVLNF 92
                         90       100       110
                 ....*....|....*....|....*....|...
gi 218505694 699 LRTSKLLIPDdfKDYTLLY-EEAKYFQLQPMLL 730
Cdd:cd18419   93 YRTGKLHYPR--YECISAYdEELAFYGILPEII 123
BTB_POZ_KCNS2 cd18427
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-704 7.19e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349734  Cd Length: 107  Bit Score: 48.31  E-value: 7.19e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFD--GTEPIV-----LDSLKQHYFIDRDGQMFRYILNFLRTSKL 704
Cdd:cd18427    2 ISINVGGFKKRLRSHTLLRFPETRLGRLLScrSKESILelcddYDDTKNEFYFDRNPELFPYVLHFYNTGKL 73
DUF3504 pfam12012
Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. ...
284-440 8.83e-07

Domain of unknown function (DUF3504); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.


Pssm-ID: 463430  Cd Length: 162  Bit Score: 49.57  E-value: 8.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694  284 ITRADLRKLYTSSVFSTNTPFGLLNKVWFETCMYFCTRGRENQRELEEDSFGLAMDEDGR-KFVYFKslgpYHKSRSSSW 362
Cdd:pfam12012   2 FSRVEEEHLWECKQLGAHSPIVLLNTLVYFNTKYFNLRTVEEHRRLSFSNVVRHTKPNPReKSTYLR----YYEPPDQVE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694  363 SKKRAESSDEENL-PRMYE--TGTEFCPYASFVKYLSKRNPLCK----AFFQRPRDHCSEGDVTWYENKAIGKNLLGtrm 435
Cdd:pfam12012  78 TGGRKKRDEGVNKvVEQHEnsENPLRCPVKLYEFYLSKCPESVKqrkdVFYLQPEPSCVPDSPLWYSSQPLGRNTLE--- 154

                  ....*
gi 218505694  436 QMLSK 440
Cdd:pfam12012 155 SMLTR 159
BTB_POZ_KCND2 cd18418
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
642-707 1.20e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349725 [Multi-domain]  Cd Length: 103  Bit Score: 47.64  E-value: 1.20e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 218505694 642 IDVGGHMYTSSLATLTKYPESRIGrlfDGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIP 707
Cdd:cd18418    4 LNVSGTRFQTWRNTLERYPDTLLG---SSERDFFYHEETQEYFFDRDPDIFRHILNFYRTGKLHYP 66
BTB_POZ_Kv6_KCNG cd18382
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
642-704 1.54e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349691 [Multi-domain]  Cd Length: 109  Bit Score: 47.43  E-value: 1.54e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 642 IDVGGHMYTSSLATLTKYPESRIGRL--FDGTEPIV-----LDSLKQHYFIDRDGQMFRYILNFLRTSKL 704
Cdd:cd18382    3 INVGGARYSLPWSTLDRFPLTRLSRLkaCRSEDDILrvcddYDVERNEFFFDRSPEAFGVILLFLRAGKL 72
BTB_POZ_KCNS3 cd18428
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-704 1.66e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349735  Cd Length: 108  Bit Score: 47.52  E-value: 1.66e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFD-GTEPIVLD------SLKQHYFIDRDGQMFRYILNFLRTSKL 704
Cdd:cd18428    3 INLNVGGFKQSVDQSTLLRFPHTRLGKLLNcHSEEAILElcddysVADKEYYFDRNPSLFRYVLNFYYTGKL 74
BTB_POZ_Kv9_KCNS cd18384
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-709 2.86e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349692  Cd Length: 106  Bit Score: 46.75  E-value: 2.86e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLF--DGTEPIV-----LDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDD 709
Cdd:cd18384    1 IRINVGGFRRRLSASALLRFPGTRLGRLLacHSEEAILelcddYDVAAREFYFDRNPGFFLYVLHFYRTGKLHVMDE 77
BTB_POZ_KCTD5 cd18390
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-729 3.97e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.


Pssm-ID: 349698 [Multi-domain]  Cd Length: 112  Bit Score: 46.52  E-value: 3.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPivLDSLKQH---YFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLL 716
Cdd:cd18390    7 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPD--LDSDKDEtgaYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVL 84
                         90
                 ....*....|...
gi 218505694 717 yEEAKYFQLQPML 729
Cdd:cd18390   85 -EEAEFYNITSLI 96
BTB_POZ_Shab-like cd18413
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
637-709 6.56e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349720 [Multi-domain]  Cd Length: 109  Bit Score: 45.64  E-value: 6.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 637 NAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGT--EPIV-----LDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDD 709
Cdd:cd18413    1 NRRVVINVGGVKHEVLWRTLDRMPHTRLGKLRDSNthEAIVelcddYSLADNEYFFDRHPRSFASILNFYRTGKLHLVEE 80
BTB_KCNC1_3 cd18414
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
642-723 1.47e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349721 [Multi-domain]  Cd Length: 117  Bit Score: 44.95  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 642 IDVGGHMYTSSLATLTKYPESRIGRLfdgTEPIVL-----DSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFkdYTLL 716
Cdd:cd18414    7 INVGGTRHETYRSTLRTLPGTRLAWL---AEPDAHsnfdyDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADV--CGPL 81

                 ....*..
gi 218505694 717 YEEAKYF 723
Cdd:cd18414   82 YEEELAF 88
BTB_POZ_KCNG1_2 cd18421
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-704 5.44e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349728 [Multi-domain]  Cd Length: 114  Bit Score: 40.51  E-value: 5.44e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRL-----FDGTEPIV--LDSLKQHYFIDRDGQMFRYILNFLRTSKL 704
Cdd:cd18421    6 VIINVGGIKYRIPWTTLEEFPLTRLGQLkscnnFDEIMDICddYDVTCNEFFFDRNPCAFRTILTFLRAGKL 77
BTB_POZ_KCNG4 cd18423
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-706 5.92e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349730 [Multi-domain]  Cd Length: 112  Bit Score: 40.19  E-value: 5.92e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRL--FDGTEPIV-----LDSLKQHYFIDRDGQMFRYILNFLRTSKLLI 706
Cdd:cd18423    4 IIINVGGIKYLMPWSTLDEFPLTRLGKLkfCSSYEEIVqicddYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRL 77
BTB_POZ_KCNA4 cd18405
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-725 1.00e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 4 (KCNA4); KCNA4 is also called HPCN2, or voltage-gated K(+) channel HuKII, voltage-gated potassium channel HBK4, voltage-gated potassium channel HK1, or voltage-gated potassium channel subunit Kv1.4. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA4 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349712  Cd Length: 97  Bit Score: 39.21  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEpiVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEE 719
Cdd:cd18405    3 VVINVSGLRFETQLKTLAQFPETLLGDPEKRMR--YFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFSEE 80

                 ....*.
gi 218505694 720 AKYFQL 725
Cdd:cd18405   81 VKFYEL 86
BTB_POZ_KCNB2 cd18412
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
628-704 1.45e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349719 [Multi-domain]  Cd Length: 127  Bit Score: 39.61  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 628 PTPAQLTKSNA---PVHIDVGGHMYTSSLATLTKYPESRIGRLFD-GTEPIVLD-----SLKQH-YFIDRDGQMFRYILN 697
Cdd:cd18412    4 PEPVEIIRSKAcsrRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDcNTHESLLEvcddyNLNENeYFFDRHPGAFTSILN 83

                 ....*..
gi 218505694 698 FLRTSKL 704
Cdd:cd18412   84 FYRTGKL 90
BTB_POZ_KCNA5 cd18406
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-738 3.56e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 5 (KCNA5); KCNA5, also called HPCN1, voltage-gated potassium channel HK2, or voltage-gated potassium channel subunit Kv1.5, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA5 may play a role in regulating the secretion of insulin in normal pancreatic islets. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA5 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349713  Cd Length: 97  Bit Score: 37.54  E-value: 3.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIG------RLFDgtepivldSLKQHYFIDRDGQMFRYILNFLRT-SKLLIP----- 707
Cdd:cd18406    3 VIINIAGLRFETQLGTLNQFPDTLLGdpdkrmRYFD--------PLRNEYFFDRNRPSFDGILYFYQSgGKIRRPvnvsi 74
                         90       100       110
                 ....*....|....*....|....*....|.
gi 218505694 708 DDFKDytllyeEAKYFQLQPMllEMERWKQD 738
Cdd:cd18406   75 DVFAD------EIRFYQLGEE--AMERFRED 97
BTB_POZ_KCNA2_KCNA3 cd18403
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-734 4.42e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A members 2 (KCNA2) and 3 (KCNA3); KCNA2 is also called NGK1, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, or voltage-gated potassium channel subunit Kv1.2. KCNA3 is also called HGK5, HLK3, HPCN3, voltage-gated K(+) channel HuKIII, or voltage-gated potassium channel subunit Kv1.3. KCNA2 and KCNA3 mediate transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA2 primarily functions in the brain and the central nervous system, but also in the cardiovascular system. It prevents aberrant action potential firing and regulates neuronal output. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA2 and KCNA3 are alpha subunits that form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349711  Cd Length: 99  Bit Score: 37.64  E-value: 4.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIG------RLFDgtepivldSLKQHYFIDRDGQMFRYILNFLRTSKLL-----IPD 708
Cdd:cd18403    3 VVINISGLRFETQLKTLAQFPETLLGdpkkrmRYFD--------PLRNEYFFDRNRPSFDAILYYYQSGGRLrrpvnVPL 74
                         90       100
                 ....*....|....*....|....*.
gi 218505694 709 DfkdytLLYEEAKYFQLQPMLLEMER 734
Cdd:cd18403   75 D-----IFSEEIRFYELGEEAMEMFR 95
BTB_POZ_KCNB1 cd18411
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-704 6.59e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349718 [Multi-domain]  Cd Length: 117  Bit Score: 37.29  E-value: 6.59e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIGRLFD-GTEPIVLDSLKQH------YFIDRDGQMFRYILNFLRTSKL 704
Cdd:cd18411   12 VKLNVGGLAHEVLWRTLDRLPRTRLGKLRDcNTHESLMEICDDYnleeneYFFDRHPGAFTSILNFYRTGKL 83
BTB_POZ_Kv1_KCNA cd18377
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
640-724 6.69e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNA/Kv1 subfamily of Shaker-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv1, also known as subfamily A, contains eight alpha subunit members, Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), and Kv1.8 (KCNA10), which are orthologs of the Shaker gene in Drosophila. They are delayed rectifiers except for Kv1.4 (KCNA4), which is an A-type potassium channel. Delayed rectifiers are slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics, they play an important role in controlling action potential duration. A-type channels are fast/rapidly inactivating potassium channels. Kv1/KCNA subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349686  Cd Length: 85  Bit Score: 36.50  E-value: 6.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 640 VHIDVGGHMYTSSLATLTKYPESRIG------RLFDgtepivldSLKQHYFIDRDGQMFRYILNFLRTSKLL-----IPD 708
Cdd:cd18377    3 VVINVSGLRFETQLKTLAQFPNTLLGdpnkrmRFFD--------PLRNEYFFDRNRPSFDAILYYYQSGGRLrrpvnVPL 74
                         90
                 ....*....|....*.
gi 218505694 709 DfkdytLLYEEAKYFQ 724
Cdd:cd18377   75 D-----IFLEEIRFYE 85
H1_KCTD12-like cd22204
H1 domain found in potassium channel tetramerization domain-containing proteins; The H1 domain ...
762-845 9.74e-03

H1 domain found in potassium channel tetramerization domain-containing proteins; The H1 domain is found in potassium channel tetramerization domain-containing proteins such as KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), KCTD12b, and KCTD16. They serve as auxiliary gamma-aminobutyric acid type B (GABA-B) receptor subunits that constitute receptor subtypes with distinct functional properties. KCTD12 and -12b generate desensitizing receptor responses while KCTD8 and -16 generate largely non-desensitizing receptor responses. They control GABA-B signaling and regulate the rise time and duration of G protein-coupled inwardly rectifying potassium (GIRK) currents, as well as enhance receptor expression levels. KCTD12 regulates agonist potency and kinetics of GABA-B receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. Members of this family consist of an N-terminal BTB domain followed by a region called the H1 domain. The BTB domain mediates interaction with the receptor. The C-terminal H1 domain, which possesses a beta-propeller-like fold, engages in interactions with G-protein beta-gamma subunits and is responsible for desensitization. This model corresponds to the H1 domain.


Pssm-ID: 409026  Cd Length: 118  Bit Score: 36.80  E-value: 9.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218505694 762 RITLSGDKSLIEEVFpeiGDVMCNSVNAGWNHDSTHVIRFPLNgYCHLNsvQVLERLQQRGFEIVGSCGGGVDS------ 835
Cdd:cd22204   29 RILVCGKVSLCREVF---GDTLNESRDPDRGEPDRYTSRFFLK-HNYLE--QAFDQLAEAGFRLVASCGSGTSGlpsagd 102
                         90
                 ....*....|....*.
gi 218505694 836 ------SQFSEYVLRR 845
Cdd:cd22204  103 seekrwNHYTEFVFVR 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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