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Conserved domains on  [gi|209529739|ref|NP_001129337|]
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nuclear pore complex-interacting protein family member B5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPIP super family cl05750
Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate ...
 41-303 6.08e-85

Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans.


The actual alignment was detected with superfamily member pfam06409:

Pssm-ID: 461900 [Multi-domain]  Cd Length: 267  Bit Score: 276.62  E-value: 6.08e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739    41 VINTLADHHHRGTDFGGSPWLHVIIAFPTSYKVVITLWIVYLWVSLLKTIFWSRNGHDGSTDVQQRAWRSNRRRQEGLrs 120
Cdd:pfam06409   22 LIITLADHRHKFADFGCSPWLCIIFLFLIFPKFAGHDCSSDLCQRALKSIFPRQEGHDGSLDDIFRARRQNERKQEAI-- 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739   121 icmhtkkrvssfrgnKIGLKDVITLRRHVETKVRAKIRKRKVTTKINHHDKINGKRKTAR---------------KQKMF 185
Cdd:pfam06409  100 ---------------ICKLEDIFKLNRHDEIKGKAKIAKEHLRKKSMKEDEHGEKEKQAKeaeekgkldekehgeKEEMF 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739   186 QRAQELRRRAEDYHKCKIPPSARKALCNWVRMAAAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKT 265
Cdd:pfam06409  165 QEAEALGKLAEDEIHCKIEMFARAPACNRRAEAAAECKHSPGAPKPLCLRAEMAAAEHGHQPGLPTQPHLIADNLKNLKG 244

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 209529739   266 PPECLLTPLPPSADdnlktppecvltplpPSADDNLKT 303
Cdd:pfam06409  245 HPECLLTPLHPIAD---------------NSADDKLKP 267
AFD_class_I super family cl17068
Adenylate forming domain, Class I superfamily; This family includes acyl- and aryl-CoA ligases, ...
 2-41 2.23e-11

Adenylate forming domain, Class I superfamily; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.


The actual alignment was detected with superfamily member cd05928:

Pssm-ID: 473059 [Multi-domain]  Cd Length: 530  Bit Score: 67.88  E-value: 2.23e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 209529739    2 VKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKV 41
Cdd:cd05928   467 VKAFVVLAPQFLSHDPEQLTKELQQHVKSVTAPYKYPRKV 506
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 871-1131 2.80e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  871 RGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAP---PSADDNI 947
Cdd:PHA03307  142 GSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSpisASASSPA 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  948 KTPAERLRGPLPPSADDNLKTPSERqltplppsappsaddniKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPK 1027
Cdd:PHA03307  222 PAPGRSAADDAGASSSDSSSSESSG-----------------CGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGP 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739 1028 RQRAA---EMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGD--------VEPSRKPKRRRAADVEPSSP 1096
Cdd:PHA03307  285 ASSSSsprERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSrgaavspgPSPSRSPSPSRPPPPADPSS 364

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 209529739 1097 EPKRRRVGDVEPSR-----KPKRRRAAdvePSLPEPKRRR 1131
Cdd:PHA03307  365 PRKRPRPSRAPSSPaasagRPTRRRAR---AAVAGRARRR 401
 
Name Accession Description Interval E-value
NPIP pfam06409
Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate ...
 41-303 6.08e-85

Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans.


Pssm-ID: 461900 [Multi-domain]  Cd Length: 267  Bit Score: 276.62  E-value: 6.08e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739    41 VINTLADHHHRGTDFGGSPWLHVIIAFPTSYKVVITLWIVYLWVSLLKTIFWSRNGHDGSTDVQQRAWRSNRRRQEGLrs 120
Cdd:pfam06409   22 LIITLADHRHKFADFGCSPWLCIIFLFLIFPKFAGHDCSSDLCQRALKSIFPRQEGHDGSLDDIFRARRQNERKQEAI-- 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739   121 icmhtkkrvssfrgnKIGLKDVITLRRHVETKVRAKIRKRKVTTKINHHDKINGKRKTAR---------------KQKMF 185
Cdd:pfam06409  100 ---------------ICKLEDIFKLNRHDEIKGKAKIAKEHLRKKSMKEDEHGEKEKQAKeaeekgkldekehgeKEEMF 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739   186 QRAQELRRRAEDYHKCKIPPSARKALCNWVRMAAAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKT 265
Cdd:pfam06409  165 QEAEALGKLAEDEIHCKIEMFARAPACNRRAEAAAECKHSPGAPKPLCLRAEMAAAEHGHQPGLPTQPHLIADNLKNLKG 244

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 209529739   266 PPECLLTPLPPSADdnlktppecvltplpPSADDNLKT 303
Cdd:pfam06409  245 HPECLLTPLHPIAD---------------NSADDKLKP 267
MACS_euk cd05928
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ...
 2-41 2.23e-11

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.


Pssm-ID: 341251 [Multi-domain]  Cd Length: 530  Bit Score: 67.88  E-value: 2.23e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 209529739    2 VKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKV 41
Cdd:cd05928   467 VKAFVVLAPQFLSHDPEQLTKELQQHVKSVTAPYKYPRKV 506
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 871-1131 2.80e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  871 RGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAP---PSADDNI 947
Cdd:PHA03307  142 GSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSpisASASSPA 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  948 KTPAERLRGPLPPSADDNLKTPSERqltplppsappsaddniKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPK 1027
Cdd:PHA03307  222 PAPGRSAADDAGASSSDSSSSESSG-----------------CGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGP 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739 1028 RQRAA---EMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGD--------VEPSRKPKRRRAADVEPSSP 1096
Cdd:PHA03307  285 ASSSSsprERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSrgaavspgPSPSRSPSPSRPPPPADPSS 364

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 209529739 1097 EPKRRRVGDVEPSR-----KPKRRRAAdvePSLPEPKRRR 1131
Cdd:PHA03307  365 PRKRPRPSRAPSSPaasagRPTRRRAR---AAVAGRARRR 401
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 1022-1133 3.09e-04

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 44.52  E-value: 3.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  1022 KPRKPKRQRAAEMEPPPEPKRRRVGDVEPSRKPKRRRAadvepSSPEPKRRRVGDvePSRKPKRRRAADVEPSSPEPK-- 1099
Cdd:TIGR01622    3 RDRERERLRDSSSAGDRDRRRDKGRERSRDRSRDRERS-----RSRRRDRHRDRD--YYRGRERRSRSRRPNRRYRPRek 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 209529739  1100 --------RRRVGDVEPSRKPKRRRAADVEPsLPEPKRRRLS 1133
Cdd:TIGR01622   76 rrrrgdsyRRRRDDRRSRREKPRARDGTPEP-LTEDERDRRT 116
 
Name Accession Description Interval E-value
NPIP pfam06409
Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate ...
 41-303 6.08e-85

Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans.


Pssm-ID: 461900 [Multi-domain]  Cd Length: 267  Bit Score: 276.62  E-value: 6.08e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739    41 VINTLADHHHRGTDFGGSPWLHVIIAFPTSYKVVITLWIVYLWVSLLKTIFWSRNGHDGSTDVQQRAWRSNRRRQEGLrs 120
Cdd:pfam06409   22 LIITLADHRHKFADFGCSPWLCIIFLFLIFPKFAGHDCSSDLCQRALKSIFPRQEGHDGSLDDIFRARRQNERKQEAI-- 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739   121 icmhtkkrvssfrgnKIGLKDVITLRRHVETKVRAKIRKRKVTTKINHHDKINGKRKTAR---------------KQKMF 185
Cdd:pfam06409  100 ---------------ICKLEDIFKLNRHDEIKGKAKIAKEHLRKKSMKEDEHGEKEKQAKeaeekgkldekehgeKEEMF 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739   186 QRAQELRRRAEDYHKCKIPPSARKALCNWVRMAAAEHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSITDNSLSLKT 265
Cdd:pfam06409  165 QEAEALGKLAEDEIHCKIEMFARAPACNRRAEAAAECKHSPGAPKPLCLRAEMAAAEHGHQPGLPTQPHLIADNLKNLKG 244

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 209529739   266 PPECLLTPLPPSADdnlktppecvltplpPSADDNLKT 303
Cdd:pfam06409  245 HPECLLTPLHPIAD---------------NSADDKLKP 267
MACS_euk cd05928
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ...
 2-41 2.23e-11

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.


Pssm-ID: 341251 [Multi-domain]  Cd Length: 530  Bit Score: 67.88  E-value: 2.23e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 209529739    2 VKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRKV 41
Cdd:cd05928   467 VKAFVVLAPQFLSHDPEQLTKELQQHVKSVTAPYKYPRKV 506
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 871-1131 2.80e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  871 RGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAP---PSADDNI 947
Cdd:PHA03307  142 GSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSpisASASSPA 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  948 KTPAERLRGPLPPSADDNLKTPSERqltplppsappsaddniKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPK 1027
Cdd:PHA03307  222 PAPGRSAADDAGASSSDSSSSESSG-----------------CGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGP 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739 1028 RQRAA---EMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGD--------VEPSRKPKRRRAADVEPSSP 1096
Cdd:PHA03307  285 ASSSSsprERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSrgaavspgPSPSRSPSPSRPPPPADPSS 364

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 209529739 1097 EPKRRRVGDVEPSR-----KPKRRRAAdvePSLPEPKRRR 1131
Cdd:PHA03307  365 PRKRPRPSRAPSSPaasagRPTRRRAR---AAVAGRARRR 401
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 1022-1133 3.09e-04

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 44.52  E-value: 3.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  1022 KPRKPKRQRAAEMEPPPEPKRRRVGDVEPSRKPKRRRAadvepSSPEPKRRRVGDvePSRKPKRRRAADVEPSSPEPK-- 1099
Cdd:TIGR01622    3 RDRERERLRDSSSAGDRDRRRDKGRERSRDRSRDRERS-----RSRRRDRHRDRD--YYRGRERRSRSRRPNRRYRPRek 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 209529739  1100 --------RRRVGDVEPSRKPKRRRAADVEPsLPEPKRRRLS 1133
Cdd:TIGR01622   76 rrrrgdsyRRRRDDRRSRREKPRARDGTPEP-LTEDERDRRT 116
PRK13709 PRK13709
conjugal transfer nickase/helicase TraI; Provisional
 999-1116 1.25e-03

conjugal transfer nickase/helicase TraI; Provisional


Pssm-ID: 237478 [Multi-domain]  Cd Length: 1747  Bit Score: 43.24  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  999 PLPPSADDNLKTPPLATQEAEAEKPRKPKRQRAAEM------EPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRR 1072
Cdd:PRK13709 1629 VQPGAGNGEPVTAEVLAQRQAEEAIRRETERRADEIvrkmaeNKPDLPDGKTEQAVRDIAGQERDRAAISEREAALPESV 1708

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 209529739 1073 rvgdvepSRKPKRRRAADVEPSSPEPKRRRVGDVE--PSRKPKRRR 1116
Cdd:PRK13709 1709 -------LREPQREREAVREVARENLLRERLQQMErdMVRDLQKEK 1747
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 1016-1116 2.40e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 41.83  E-value: 2.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  1016 QEAEAEKPRKPKRQRAAEMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPK---RRRVGDVEPSRKPKRRRAadve 1092
Cdd:TIGR01622   19 RDRRRDKGRERSRDRSRDRERSRSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPRekrRRRGDSYRRRRDDRRSRR---- 94

                           90       100
                   ....*....|....*....|....
gi 209529739  1093 psspEPKRRRVGDVEPSRKPKRRR 1116
Cdd:TIGR01622   95 ----EKPRARDGTPEPLTEDERDR 114
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 952-1116 2.41e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.81  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  952 ERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQRA 1031
Cdd:PRK12678   57 EARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEA 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739 1032 AEMEPPPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRRRVGDVEPSRK 1111
Cdd:PRK12678  137 ARRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRRE 216


                  ....*
gi 209529739 1112 PKRRR 1116
Cdd:PRK12678  217 ERGRR 221
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 867-1133 4.62e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 4.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  867 GERLRGPLPPSADdnlkTPSERQLTPLPPSAPPSADDNIKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDN 946
Cdd:PHA03307  100 PAREGSPTPPGPS----SPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALP 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  947 IKTPAERLRGPLPPSADDNLKTPSERQLTPLPPSAP---PSADDNIKTPAERLRGPLPPSADDNLKTPPLATQEAEAEKP 1023
Cdd:PHA03307  176 LSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSpisASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENEC 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739 1024 RKPkrqRAAEMEPPPEPKRRRVGDVEPSRKPKRR-RAADVEPS-SPEPKRRRVGDVEPSRKPKRRRAADVEPSSPEPKRR 1101
Cdd:PHA03307  256 PLP---RPAPITLPTRIWEASGWNGPSSRPGPASsSSSPRERSpSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSS 332

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 209529739 1102 RVGD--------VEPSRKPKRRRAADVEPSLPEPKRRRLS 1133
Cdd:PHA03307  333 SESSrgaavspgPSPSRSPSPSRPPPPADPSSPRKRPRPS 372
MACS_like cd05972
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ...
 1-41 7.09e-03

Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.


Pssm-ID: 341276 [Multi-domain]  Cd Length: 428  Bit Score: 40.40  E-value: 7.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 209529739    1 MVKLSIVLTPQFLSHDQgqLTKELQQHVKSVTCPCEYLRKV 41
Cdd:cd05972   369 VVKAFVVLTSGYEPSEE--LAEELQGHVKKVLAPYKYPREI 407
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 1016-1102 7.78e-03

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 40.29  E-value: 7.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  1016 QEAEAEKPRKPKRQRAAEMEPPPEPKRRRVGDvEPSRKPKRRRAADVEPSSPEPKRrrvGDVEPSRKPKRRRAADVEPSS 1095
Cdd:TIGR01622   33 RSRDRERSRSRRRDRHRDRDYYRGRERRSRSR-RPNRRYRPREKRRRRGDSYRRRR---DDRRSRREKPRARDGTPEPLT 108


                   ....*..
gi 209529739  1096 PEPKRRR 1102
Cdd:TIGR01622  109 EDERDRR 115
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 990-1126 9.31e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.06  E-value: 9.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209529739  990 KTPAERLRGPLPPSADDNLKTPPLATQEAEAEKPRKPKRQRAAEMEP--------PPEPKRRRvgDVEPSRKPKRRRAAD 1061
Cdd:PTZ00449  527 KEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPtlskkpefPKDPKHPK--DPEEPKKPKRPRSAQ 604

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 209529739 1062 VEPSSPEPKRRRVGDVEPSRKPKRRRAADVEPSSPE----PKRRRVGDVEPSRKPKRRRAADVEPSLPE 1126
Cdd:PTZ00449  605 RPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQrpssPERPEGPKIIKSPKPPKSPKPPFDPKFKE 673
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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