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Conserved domains on  [gi|197276600|ref|NP_001127836|]
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microtubule-associated protein 4 isoform 4 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 992-1021 1.61e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 1.61e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 197276600   992 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 1021
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1023-1052 2.53e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.53e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 197276600  1023 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 1052
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 575-919 3.15e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 3.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  575 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 653
Cdd:PHA03247 2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  654 CNSQPSELSSETSGiARPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTI 733
Cdd:PHA03247 2669 RLGRAAQASSPPQR-PRRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  734 GGLNKKPMSLASGLVPAAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTT 811
Cdd:PHA03247 2745 PAGPATPGGPARPARPPTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  812 TAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVV 885
Cdd:PHA03247 2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQ 2904

                         330       340       350
                  ....*....|....*....|....*....|....
gi 197276600  886 PSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPR 919
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1054-1084 5.10e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 5.10e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 197276600  1054 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1084
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 931-952 2.61e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.49  E-value: 2.61e-08
                           10        20
                   ....*....|....*....|..
gi 197276600   931 DLKNVRSKVGSTENIKHQPGGG 952
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 992-1021 1.61e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 1.61e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 197276600   992 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 1021
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1023-1052 2.53e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.53e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 197276600  1023 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 1052
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 575-919 3.15e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 3.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  575 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 653
Cdd:PHA03247 2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  654 CNSQPSELSSETSGiARPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTI 733
Cdd:PHA03247 2669 RLGRAAQASSPPQR-PRRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  734 GGLNKKPMSLASGLVPAAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTT 811
Cdd:PHA03247 2745 PAGPATPGGPARPARPPTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  812 TAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVV 885
Cdd:PHA03247 2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQ 2904

                         330       340       350
                  ....*....|....*....|....*....|....
gi 197276600  886 PSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPR 919
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1054-1084 5.10e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 5.10e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 197276600  1054 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1084
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 931-952 2.61e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.49  E-value: 2.61e-08
                           10        20
                   ....*....|....*....|..
gi 197276600   931 DLKNVRSKVGSTENIKHQPGGG 952
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 665-986 5.41e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.60  E-value: 5.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   665 TSGIARPEegrpVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMS 742
Cdd:pfam05109  436 TTGFAAPN----TTTGLPSSTHVPTNLTAPAStgPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTS 511

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   743 LASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRA----------------------SPSKPASAPASRSG 800
Cdd:pfam05109  512 AVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNAtsptpavttptpnatiptlgktSPTSAVTTPTPNAT 591

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   801 SKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGK----PAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLS 876
Cdd:pfam05109  592 SPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQhnitSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLT 671

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   877 GTAPAAG-----VVPSRVK------ATPMPsRPSTTPFID---KKPTSAKP------------SSTTPRLSRlATNTSAP 930
Cdd:pfam05109  672 SAHPTGGenitqVTPASTSthhvstSSPAP-RPGTTSQASgpgNSSTSTKPgevnvtkgtppkNATSPQAPS-GQKTAVP 749

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 197276600   931 DLKNVRSKVGSTENIKHQPG-GGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQK 986
Cdd:pfam05109  750 TVTSTGGKANSTTGGKHTTGhGARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSK 806
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 992-1021 1.61e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 1.61e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 197276600   992 VQIVSKKVSYSHIQSKCGSKDNIKHVPGGG 1021
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1023-1052 2.53e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 64.74  E-value: 2.53e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 197276600  1023 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 1052
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 575-919 3.15e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 3.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  575 DVPPLSETEATPVPIKDMEIAQTQKGISE-DSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLeKLGERKP 653
Cdd:PHA03247 2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPpDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRAR 2668

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  654 CNSQPSELSSETSGiARPEEGRPVVSGTGNDITTPPNkelPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTI 733
Cdd:PHA03247 2669 RLGRAAQASSPPQR-PRRRAARPTVGSLTSLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV 2744

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  734 GGLNKKPMSLASGLVPAAP--PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTT 811
Cdd:PHA03247 2745 PAGPATPGGPARPARPPTTagPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  812 TAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAE----VKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA--GVV 885
Cdd:PHA03247 2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlpPDQ 2904

                         330       340       350
                  ....*....|....*....|....*....|....
gi 197276600  886 PSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPR 919
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1054-1084 5.10e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.41  E-value: 5.10e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 197276600  1054 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1084
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 931-952 2.61e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 50.49  E-value: 2.61e-08
                           10        20
                   ....*....|....*....|..
gi 197276600   931 DLKNVRSKVGSTENIKHQPGGG 952
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 668-925 8.51e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 8.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  668 IARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTS----LPKQPAPTTIGGLNKKPmSL 743
Cdd:PHA03247 2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESReslpSPWDPADPPAAVLAPAA-AL 2818

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  744 ASGLVPAAP-PKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPS 822
Cdd:PHA03247 2819 PPAASPAGPlPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF 2898

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  823 SRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADlsRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTP 902
Cdd:PHA03247 2899 ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP--PPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR 2976

                         250       260
                  ....*....|....*....|....*
gi 197276600  903 FI--DKKPTSAKPSSTTPRLSRLAT 925
Cdd:PHA03247 2977 FRvpQPAPSREAPASSTPPLTGHSL 3001
PHA03247 PHA03247
large tegument protein UL36; Provisional
 653-924 5.48e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 5.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  653 PCNSQPSELSSETSGIARPEEGRPVVSG--TGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAP 730
Cdd:PHA03247 2575 PRPSEPAVTSRARRPDAPPQSARPRAPVddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRD 2654

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  731 TTIGG---LNKKPMSLASGLVPAAPPKRPAVASARPSI---------------------------------------LPS 768
Cdd:PHA03247 2655 DPAPGrvsRPRRARRLGRAAQASSPPQRPRRRAARPTVgsltsladpppppptpepaphalvsatplppgpaaarqaSPA 2734

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  769 KDVKPKPIADAKAPEKRASPSKPASaPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVkk 848
Cdd:PHA03247 2735 LPAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAV-- 2811

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  849 mtakSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKP----SSTTPRLSRLA 924
Cdd:PHA03247 2812 ----LAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAakpaAPARPPVRRLA 2887
PHA03247 PHA03247
large tegument protein UL36; Provisional
 660-988 2.46e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 2.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  660 ELSSETSGIARPEEGrPVVSGTGNDITTPPNKELPPSPE-----KKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPttig 734
Cdd:PHA03247 2542 ELASDDAGDPPPPLP-PAAPPAAPDRSVPPPRPAPRPSEpavtsRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---- 2616

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  735 glnkkpmslasgLVPAAPPKRPAVASARPSilPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAA 814
Cdd:PHA03247 2617 ------------LPPDTHAPDPPPPSPSPA--ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR 2682

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  815 AVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPM 894
Cdd:PHA03247 2683 PRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  895 PSRPSTTpfidkKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIkhQPGGGRAKVEKKTEAAATTRKPESnAV 974
Cdd:PHA03247 2763 TAGPPAP-----APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP--AAVLAPAAALPPAASPAGPLPPPT-SA 2834

                         330
                  ....*....|....
gi 197276600  975 TKTAGPIASAQKQP 988
Cdd:PHA03247 2835 QPTAPPPPPGPPPP 2848
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 573-930 2.74e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.71  E-value: 2.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  573 AKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERK 652
Cdd:PHA03307   15 AEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLST 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  653 PCNSQPSELSSETSGIARPEEGRPvvsgtgndiTTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTt 732
Cdd:PHA03307   95 LAPASPAREGSPTPPGPSSPDPPP---------PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVAS- 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  733 iGGLNKKPMSLASGLVPAA-----PPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTV 807
Cdd:PHA03307  165 -DAASSRQAALPLSSPEETarapsSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSE 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  808 AKTTTAAAVASTGPSSRSPSTLLPKKPTAIktEGKPAEVKKMTAKSVPADLSR-----------PKSTSTSSMKKTTTLS 876
Cdd:PHA03307  244 SSGCGWGPENECPLPRPAPITLPTRIWEAS--GWNGPSSRPGPASSSSSPRERspspspsspgsGPAPSSPRASSSSSSS 321

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 197276600  877 GTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAP 930
Cdd:PHA03307  322 RESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAP 375
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
727-989 1.08e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.85  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  727 QPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASAR-------PSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRS 799
Cdd:PRK07003  359 EPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASavpavtaVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  800 GSKSTQtvaktttaaavastgpssrSPSTLLPKKPTAIKTEGKPAEvkkmtAKSVPADLSRPKSTSTSSMKKTTTLSGTA 879
Cdd:PRK07003  439 GDDAAD-------------------GDAPVPAKANARASADSRCDE-----RDAQPPADSGSASAPASDAPPDAAFEPAP 494

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  880 PAAGVVPSRVKATPMPSRPSTTPFIDK-------KPTSAKPSSTTPRLSRLATNTSAP--DLKNVRSKVGSTeniKHQPG 950
Cdd:PRK07003  495 RAAAPSAATPAAVPDARAPAAASREDApaaaappAPEARPPTPAAAAPAARAGGAAAAldVLRNAGMRVSSD---RGARA 571

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 197276600  951 GGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPA 989
Cdd:PRK07003  572 AAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPP 610
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 665-986 5.41e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.60  E-value: 5.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   665 TSGIARPEegrpVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMS 742
Cdd:pfam05109  436 TTGFAAPN----TTTGLPSSTHVPTNLTAPAStgPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTS 511

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   743 LASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRA----------------------SPSKPASAPASRSG 800
Cdd:pfam05109  512 AVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNAtsptpavttptpnatiptlgktSPTSAVTTPTPNAT 591

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   801 SKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGK----PAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLS 876
Cdd:pfam05109  592 SPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQhnitSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLT 671

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   877 GTAPAAG-----VVPSRVK------ATPMPsRPSTTPFID---KKPTSAKP------------SSTTPRLSRlATNTSAP 930
Cdd:pfam05109  672 SAHPTGGenitqVTPASTSthhvstSSPAP-RPGTTSQASgpgNSSTSTKPgevnvtkgtppkNATSPQAPS-GQKTAVP 749

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 197276600   931 DLKNVRSKVGSTENIKHQPG-GGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQK 986
Cdd:pfam05109  750 TVTSTGGKANSTTGGKHTTGhGARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSK 806
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 578-930 1.20e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 1.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   578 PLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTF----MISPE---TVTGTGKKCSLPAEEDSVLEklge 650
Cdd:pfam05109  425 PESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVstadVTSPTpagTTSGASPVTPSPSPRDNGTE---- 500

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   651 rkpcnSQPSELSSETSGIARPEegrPVVSGTGNDITTP-PNKELP-------------PSPEKKTKPLATTQPAKTST-- 714
Cdd:pfam05109  501 -----SKAPDMTSPTSAVTTPT---PNATSPTPAVTTPtPNATSPtlgktsptsavttPTPNATSPTPAVTTPTPNATip 572

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   715 SKAKTQPTSLPKQPAPT------------------TIGGLNKKPmslasglVPAAPPKRP--AVASARPSILPSK----D 770
Cdd:pfam05109  573 TLGKTSPTSAVTTPTPNatsptvgetspqanttnhTLGGTSSTP-------VVTSPPKNAtsAVTTGQHNITSSStssmS 645

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   771 VKPKPIADAKAPEK--RASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTG-PSSRSPSTLLPKKPTAIKTEGKPAEV- 846
Cdd:pfam05109  646 LRPSSISETLSPSTsdNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSsPAPRPGTTSQASGPGNSSTSTKPGEVn 725

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   847 -------KKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVvPSRVKATPMPSR--PSTTPFIDKKPTSAKPSSTT 917
Cdd:pfam05109  726 vtkgtppKNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGH-GARTSTEPTTDYggDSTTPRTRYNATTYLPPSTS 804

                          410
                   ....*....|...
gi 197276600   918 PRLSRLATNTSAP 930
Cdd:pfam05109  805 SKLRPRWTFTSPP 817
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 638-994 3.25e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 3.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   638 PAEEDSVLEKLGERKPCNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKT-----KPLATTQPAKT 712
Cdd:pfam03154  151 PQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATsqppnQTQSTAAPHTL 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   713 STSKAKTQPTSLPK-----QPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKdVKPKPIADAKAPEKRAS 787
Cdd:pfam03154  231 IQQTPTLHPQRLPSphpplQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHP-VPPQPFPLTPQSSQSQV 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   788 PSKPASA-----------PASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAiKTEGKPAEVKKMTAKSVPA 856
Cdd:pfam03154  310 PPGPSPAapgqsqqrihtPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNP-QSHKHPPHLSGPSPFQMNS 388

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600   857 DLSRPKSTST-SSMKKTTTLSGTAPAAGVVPsrvKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNV 935
Cdd:pfam03154  389 NLPPPPALKPlSSLSTHHPPSAHPPPLQLMP---QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQH 465

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 197276600   936 RSKVGSTENIKHQPGggrakVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQI 994
Cdd:pfam03154  466 PFVPGGPPPITPPSG-----PPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQI 519
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
665-930 8.40e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 8.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  665 TSGIARPEEGRPVVSGT--GNDITTPPNKELPPSPEKKTKPLATTQPA--KTSTSKAKTQPTSLPKQPAPTTIGGLNKKP 740
Cdd:PRK07003  363 TGGGAPGGGVPARVAGAvpAPGARAAAAVGASAVPAVTAVTGAAGAALapKAAAAAAATRAEAPPAAPAPPATADRGDDA 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  741 MSlasglVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTG 820
Cdd:PRK07003  443 AD-----GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAS 517

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  821 PSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPST 900
Cdd:PRK07003  518 REDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVP 597

                         250       260       270
                  ....*....|....*....|....*....|
gi 197276600  901 TPFIDKKPTSAKPSSTTPRLSRLATNTSAP 930
Cdd:PRK07003  598 TPRARAATGDAPPNGAARAEQAAESRGAPP 627
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 752-913 2.15e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.37  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  752 PPKRPAvASARPsilpskdvkPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPS-----SRSP 826
Cdd:PTZ00449  510 PPEGPE-ASGLP---------PKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSkiptlSKKP 579

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  827 StlLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTL--SGTAPAAGVVPSRVKAtpmPSRPSTT--P 902
Cdd:PTZ00449  580 E--FPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRpeSPKSPKRPPPPQRPSS---PERPEGPkiI 654

                         170
                  ....*....|.
gi 197276600  903 FIDKKPTSAKP 913
Cdd:PTZ00449  655 KSPKPPKSPKP 665
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 653-928 2.42e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.98  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  653 PCNSQPSELSSETS-GIARPEEGRPVVSGTGNDITTPPNkelPPSPEKKTK-PLATTQPAKTSTSKAKTQPTS--LPKQP 728
Cdd:PTZ00449  524 PGDKEGEEGEHEDSkESDEPKEGGKPGETKEGEVGKKPG---PAKEHKPSKiPTLSKKPEFPKDPKHPKDPEEpkKPKRP 600

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  729 APTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPA---------------S 793
Cdd:PTZ00449  601 RSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKppfdpkfkekfyddyL 680

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  794 APASRSGSKSTQTVAKTTTAAAVASTGPSS-----RSPSTLLPKKPTAIKTEGKPaeVKKMTAKSV-PADLSRPKSTSTS 867
Cdd:PTZ00449  681 DAAAKSKETKTTVVLDESFESILKETLPETpgtpfTTPRPLPPKLPRDEEFPFEP--IGDPDAEQPdDIEFFTPPEEERT 758

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 197276600  868 SMKKTttlSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTP------------RLSRLATNTS 928
Cdd:PTZ00449  759 FFHET---PADTPLPDILAEEFKEEDIHAETGEPDEAMKRPDSPSEHEDKPpgdhpslpkkrhRLDGLALSTT 828
PHA03378 PHA03378
EBNA-3B; Provisional
 672-992 3.82e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 3.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  672 EEGRPVVSGTGNDITTPPNK----ELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGL 747
Cdd:PHA03378  549 ESDEPASTEPVHDQLLPAPGlgplQIQPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPL 628

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  748 VP-AAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSP 826
Cdd:PHA03378  629 RPiPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPA 708

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  827 STLLPKKPTAIKTEGKPAEVKKMTAKSVPADL---SRPKSTSTSSMKKTTTLSGTAPAAGVVPSRvkATPMPsRPSTTPF 903
Cdd:PHA03378  709 APPGRAQRPAAATGRARPPAAAPGRARPPAAApgrARPPAAAPGRARPPAAAPGRARPPAAAPGA--PTPQP-PPQAPPA 785

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  904 IDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRskvGSTENIKHQPGGGRAKvekktEAAATTRKPESNAVTKTAGPIAS 983
Cdd:PHA03378  786 PQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQ---GPTKQILRQLLTGGVK-----RGRPSLKKPAALERQAAAGPTPS 857


                  ....*....
gi 197276600  984 AQKQPAGKV 992
Cdd:PHA03378  858 PGSGTSDKI 866
PHA03247 PHA03247
large tegument protein UL36; Provisional
 557-895 5.34e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  557 PLAKDGVLTLANNVTPAkdvPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKkcs 636
Cdd:PHA03247 2686 RAARPTVGSLTSLADPP---PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR--- 2759

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  637 lPAEEDSVLEKLGERKPCNSQPSELS---SETSGIARPEEGRPVVSGTGNDITTPPNKELPPS--PEKKTKPLATTQPAK 711
Cdd:PHA03247 2760 -PPTTAGPPAPAPPAAPAAGPPRRLTrpaVASLSESRESLPSPWDPADPPAAVLAPAAALPPAasPAGPLPPPTSAQPTA 2838

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  712 TSTSKAKTQPtSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDV------------KPKPIADA 779
Cdd:PHA03247 2839 PPPPPGPPPP-SLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESfalppdqperppQPQAPPPP 2917

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  780 KAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPkkptaikteGKPAEVKKMTAKSVPadlS 859
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP---------GRVAVPRFRVPQPAP---S 2985

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 197276600  860 RPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMP 895
Cdd:PHA03247 2986 REAPASSTPPLTGHSLSRVSSWASSLALHEETDPPP 3021
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 508-921 8.40e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 40.48  E-value: 8.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  508 PLSETEMALGKDVTPPPETEVvliKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAkDVPPLSETEATPV 587
Cdd:PRK14949  343 PKSGLEMALLRAVAFVPEKPV---KRWQVDDPAEISLPEGQTPSALAAAVQAPHANEPQFVNAAPA-EKKTALTEQTTAQ 418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  588 PIKDMEIAQTQKGISEDSHLESLQDVG---QSAAPTFMISPETV-------TGTGKKCSLPAEEDSVLEKLGErKPCNSQ 657
Cdd:PRK14949  419 QQVQAANAEAVAEADASAEPADTVEQAlddESELLAALNAEQAVilsqaqsQGFEASSSLDADNSAVPEQIDS-TAEQSV 497

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  658 PSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEK-----KTKPLATTQP---AKTSTSKAKTQPTSLPKQPA 729
Cdd:PRK14949  498 VNPSVTDTQVDDTSASNNSAADNTVDDNYSAEDTLESNGLDEgdyaqDSAPLDAYQDdyvAFSSESYNALSDDEQHSANV 577

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  730 PTTIGGLNKKPMSLASGLVPAAPPKRP---------AVASARPSIL-------PSKDVKPKPIADAK--APEKRASPSKP 791
Cdd:PRK14949  578 QSAQSAAEAQPSSQSLSPISAVTTAAAsladddildAVLAARDSLLsdldalsPKEGDGKKSSADRKpkTPPSRAPPASL 657

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  792 ASAPAS-RSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKkmtAKSVPADLSRPKSTSTSSMK 870
Cdd:PRK14949  658 SKPASSpDASQTSASFDLDPDFELATHQSVPEAALASGSAPAPPPVPDPYDRPPWEE---APEVASANDGPNNAAEGNLS 734

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 197276600  871 KTTTLSGTAPAAGVVPsrvKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLS 921
Cdd:PRK14949  735 ESVEDASNSELQAVEQ---QATHQPQVQAEAQSPASTTALTQTSSEVQDTE 782
PHA03247 PHA03247
large tegument protein UL36; Provisional
 447-801 8.78e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  447 ARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPET 526
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA 2746

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  527 EVVLIKNVCLP-----PEMEVALTEDQVPALKTEAPLAKDGVLTLANNvTPAKDVPPLSETEATPVPIKDMEIAQTQKGI 601
Cdd:PHA03247 2747 GPATPGGPARParpptTAGPPAPAPPAAPAAGPPRRLTRPAVASLSES-RESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  602 SEDSHLESLQDVGQSAAPTFMISPETVTGTgkkcSLPAEEdsvlekLGERKPCNSQPSELSSETSGIARpEEGRPVVSGT 681
Cdd:PHA03247 2826 GPLPPPTSAQPTAPPPPPGPPPPSLPLGGS----VAPGGD------VRRRPPSRSPAAKPAAPARPPVR-RLARPAVSRS 2894

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197276600  682 GNDITTPPNK-ELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGglnKKPMSLASGLVPAapPKRPAVAS 760
Cdd:PHA03247 2895 TESFALPPDQpERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD---PAGAGEPSGAVPQ--PWLGALVP 2969

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 197276600  761 ARPSILPSKDVKPKPIADAKAPekraSPSKPASAPASRSGS 801
Cdd:PHA03247 2970 GRVAVPRFRVPQPAPSREAPAS----STPPLTGHSLSRVSS 3006
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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