NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|166235138|ref|NP_001107571|]
View 

seizure 6-like protein 2 isoform 3 precursor [Homo sapiens]

Protein Classification

CUB and CCP domain-containing protein( domain architecture ID 12870549)

CUB and CCP domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 457-547 2.59e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.00  E-value: 2.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 457 CGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ 530
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90
                 ....*....|....*..
gi 166235138 531 PRRRLLSSGPDLTLQFQ 547
Cdd:cd00041   81 LPPPIISSGNSLTVRFR 97
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 595-758 6.97e-17

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 81.62  E-value: 6.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 595 GTVLTYQCEPGYELLGSDILTCQW----DLSWSAAPPACQKImTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLE 670
Cdd:PHA02927 105 GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 671 GAAMLTCYSRDtgtpkWSDRvPKCALKyePCLNPGVpENGY-QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpS 749
Cdd:PHA02927 184 GNSGVLCSGGE-----WSDP-PTCQIV--KCPHPTI-SNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG--N 252


                 ....*....
gi 166235138 750 QWTSQPPLC 758
Cdd:PHA02927 253 TWQPELPKC 261
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 279-347 3.57e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.45  E-value: 3.57e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 166235138 279 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 347
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsYDYLEIYDGPSTSSPLL 73
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 103-215 8.48e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.82  E-value: 8.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 103 CNNNIS-EGEGYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGSpglaprlla 176
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPN---NLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPST--------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 166235138 177 NSSMLGE------GQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQA 215
Cdd:cd00041   69 SSPLLGRfcgstlPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 220-275 3.43e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


:

Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.38  E-value: 3.43e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 166235138   220 CGFPPRPAHGDVSV--TDLHPGGTATFHCDSGYQLQGEETLICLNGTrpSWNGETPSC 275
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLENG--TWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
394-453 2.55e-06

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.18  E-value: 2.55e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 166235138  394 CFAPF-LAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 453
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRLV---GSPTITCQE--DGTWSPPFPEC 56
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 457-547 2.59e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.00  E-value: 2.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 457 CGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ 530
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90
                 ....*....|....*..
gi 166235138 531 PRRRLLSSGPDLTLQFQ 547
Cdd:cd00041   81 LPPPIISSGNSLTVRFR 97
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 595-758 6.97e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 81.62  E-value: 6.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 595 GTVLTYQCEPGYELLGSDILTCQW----DLSWSAAPPACQKImTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLE 670
Cdd:PHA02927 105 GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 671 GAAMLTCYSRDtgtpkWSDRvPKCALKyePCLNPGVpENGY-QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpS 749
Cdd:PHA02927 184 GNSGVLCSGGE-----WSDP-PTCQIV--KCPHPTI-SNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG--N 252


                 ....*....
gi 166235138 750 QWTSQPPLC 758
Cdd:PHA02927 253 TWQPELPKC 261
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 279-347 3.57e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.45  E-value: 3.57e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 166235138 279 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 347
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsYDYLEIYDGPSTSSPLL 73
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 574-630 5.45e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 61.32  E-value: 5.45e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 166235138 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 630
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 103-215 8.48e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.82  E-value: 8.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 103 CNNNIS-EGEGYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGSpglaprlla 176
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPN---NLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPST--------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 166235138 177 NSSMLGE------GQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQA 215
Cdd:cd00041   69 SSPLLGRfcgstlPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
457-547 1.48e-11

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 61.93  E-value: 1.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138  457 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-----GDMLTLFDGDGPSARVLAQLRGPQP 531
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDhdecgYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90
                  ....*....|....*.
gi 166235138  532 RRRLLSSGPDLTLQFQ 547
Cdd:pfam00431  81 PEDIVSSSNQMTIKFV 96
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 574-629 1.77e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 59.85  E-value: 1.77e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 166235138   574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 629
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 466-547 3.37e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 60.48  E-value: 3.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138   466 GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ-PRRRLLSSG 539
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEaPPPVISSSS 80


                   ....*...
gi 166235138   540 PDLTLQFQ 547
Cdd:smart00042  81 NSLTLTFV 88
Sushi pfam00084
Sushi repeat (SCR repeat);
574-629 7.99e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 57.89  E-value: 7.99e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 166235138  574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 629
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 220-275 3.43e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.38  E-value: 3.43e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 166235138   220 CGFPPRPAHGDVSV--TDLHPGGTATFHCDSGYQLQGEETLICLNGTrpSWNGETPSC 275
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLENG--TWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 220-275 6.24e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.55  E-value: 6.24e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 166235138 220 CGFPPRPAHGDV--SVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTrpsWNGETPSC 275
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGG---WSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
220-275 1.95e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 51.35  E-value: 1.95e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 166235138  220 CGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQGEETLICLNGtrPSWNGETPSC 275
Cdd:pfam00084   1 CPPPPDIPNGKVSATKneYNYGASVSYECDPGYRLVGSPTITCQED--GTWSPPFPEC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 289-347 5.95e-08

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 51.24  E-value: 5.95e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 166235138   289 GRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN----DRLMVRSGGSPLSPVI 347
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASSPLL 63
Sushi pfam00084
Sushi repeat (SCR repeat);
394-453 2.55e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.18  E-value: 2.55e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 166235138  394 CFAPF-LAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 453
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRLV---GSPTITCQE--DGTWSPPFPEC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 112-213 1.31e-05

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 44.69  E-value: 1.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138   112 GYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGggsPGLAPRLLAN--SSMLGEg 184
Cdd:smart00042   1 GTITSPNYPQSYPN---NLDCVWTIRAPPGYRIELQFTDFDLESSDNceydyVEIYDG---PSASSPLLGRfcGSEAPP- 73

                           90       100
                   ....*....|....*....|....*....
gi 166235138   185 QVLRSPTNRLLLHFQSPRVPRGGGFRIHY 213
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
279-347 6.06e-05

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 43.05  E-value: 6.06e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 166235138  279 CGGTIHNATlGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 347
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHdecgYDYVEIRDGPSASSPLL 72
CUB pfam00431
CUB domain;
103-213 1.54e-04

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 41.90  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138  103 CNNNISEGEGYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGspglaprllAN 177
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPP---NKDCVWLIRAPPGFRVKLTFQDFELEDHDEcgydyVEIRDGPS---------AS 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 166235138  178 SSMLGE------GQVLRSPTNRLLLHFQSPRVPRGGGFRIHY 213
Cdd:pfam00431  69 SPLLGRfcgsgiPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 397-454 1.68e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.14  E-value: 1.68e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 166235138 397 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPACK 454
Cdd:cd00033    5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV---GSSTITCTE--NGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 397-453 6.73e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.28  E-value: 6.73e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 166235138   397 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 453
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLI---GSSTITCLE--NGTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 206-275 1.97e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 40.79  E-value: 1.97e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 166235138 206 GGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPS--WNGETPSC 275
Cdd:PHA02927  72 GTGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDFGSSITYSCNSGYQLIGESKSYCELGSTGSmvWNPEAPIC 143
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 457-547 2.59e-19

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 84.00  E-value: 2.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 457 CGGELSEPA-GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ 530
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90
                 ....*....|....*..
gi 166235138 531 PRRRLLSSGPDLTLQFQ 547
Cdd:cd00041   81 LPPPIISSGNSLTVRFR 97
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 595-758 6.97e-17

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 81.62  E-value: 6.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 595 GTVLTYQCEPGYELLGSDILTCQW----DLSWSAAPPACQKImTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLE 670
Cdd:PHA02927 105 GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 671 GAAMLTCYSRDtgtpkWSDRvPKCALKyePCLNPGVpENGY-QTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpS 749
Cdd:PHA02927 184 GNSGVLCSGGE-----WSDP-PTCQIV--KCPHPTI-SNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG--N 252


                 ....*....
gi 166235138 750 QWTSQPPLC 758
Cdd:PHA02927 253 TWQPELPKC 261
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 279-347 3.57e-15

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 72.45  E-value: 3.57e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 166235138 279 CGGTIHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 347
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsYDYLEIYDGPSTSSPLL 73
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 595-767 9.14e-14

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 72.38  E-value: 9.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 595 GTVLTYQCEPGY--ELLGSDILTCQWDlSWSAAPPACQKimTCADPGEIANGHRTASDAGFpvGSHVQYRCLPGYSLEGA 672
Cdd:PHA02927  47 GDTIEYLCLPGYrkQKMGPIYAKCTGT-GWTLFNQCIKR--RCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 673 AMLTCYSRDTGTPKWSDRVPKCalKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpsQWt 752
Cdd:PHA02927 122 SKSYCELGSTGSMVWNPEAPIC--ESVKCQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG---EW- 195

                        170
                 ....*....|....*
gi 166235138 753 SQPPLCKVTQTTDPS 767
Cdd:PHA02927 196 SDPPTCQIVKCPHPT 210
PHA02639 PHA02639
EEV host range protein; Provisional
 631-769 2.90e-13

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 71.23  E-value: 2.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 631 KIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYsRDTGTPKWSDRVPKCALKyePCLNPGVPENG 710
Cdd:PHA02639  18 KSIYCDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCI-KDKNNAIWSNKAPFCMLK--ECNDPPSIING 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 166235138 711 YQTLYKHHYQAGESLRFFCYE----GFELIGEVTITCVpgHPSQWTSQPPLCKVTQTTDPSRQ 769
Cdd:PHA02639  95 KIYNKREMYKVGDEIYYVCNEhkgvQYSLVGNEKITCI--QDKSWKPDPPICKMINCRFPALQ 155
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 574-630 5.45e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 61.32  E-value: 5.45e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 166235138 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQ 630
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 701-759 7.97e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 60.94  E-value: 7.97e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 166235138 701 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpSQWTSQPPLCK 759
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN--GGWSPPPPTCE 57
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 103-215 8.48e-12

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 62.82  E-value: 8.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 103 CNNNIS-EGEGYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGSpglaprlla 176
Cdd:cd00041    1 CGGTLTaSTSGTISSPNYPNNYPN---NLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPST--------- 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 166235138 177 NSSMLGE------GQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQA 215
Cdd:cd00041   69 SSPLLGRfcgstlPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
457-547 1.48e-11

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 61.93  E-value: 1.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138  457 CGGELSEPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVRE-----GDMLTLFDGDGPSARVLAQLRGPQP 531
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDhdecgYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90
                  ....*....|....*.
gi 166235138  532 RRRLLSSGPDLTLQFQ 547
Cdd:pfam00431  81 PEDIVSSSNQMTIKFV 96
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 574-629 1.77e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 59.85  E-value: 1.77e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 166235138   574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 629
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 466-547 3.37e-11

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 60.48  E-value: 3.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138   466 GVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREG-----DMLTLFDGDGPSARVLAQLRGPQ-PRRRLLSSG 539
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEaPPPVISSSS 80


                   ....*...
gi 166235138   540 PDLTLQFQ 547
Cdd:smart00042  81 NSLTLTFV 88
Sushi pfam00084
Sushi repeat (SCR repeat);
574-629 7.99e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 57.89  E-value: 7.99e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 166235138  574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPAC 629
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 635-694 1.01e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.54  E-value: 1.01e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138   635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCysrdTGTPKWSDRVPKC 694
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITC----LENGTWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 701-758 1.06e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 57.54  E-value: 1.06e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 166235138   701 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpSQWTSQPPLC 758
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN--GTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 635-694 1.15e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.47  E-value: 1.15e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCysrdTGTPKWSDRVPKC 694
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITC----TENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 220-275 3.43e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.38  E-value: 3.43e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 166235138   220 CGFPPRPAHGDVSV--TDLHPGGTATFHCDSGYQLQGEETLICLNGTrpSWNGETPSC 275
Cdd:smart00032   1 CPPPPDIENGTVTSssGTYSYGDTVTYSCDPGYTLIGSSTITCLENG--TWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 220-275 6.24e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 55.55  E-value: 6.24e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 166235138 220 CGFPPRPAHGDV--SVTDLHPGGTATFHCDSGYQLQGEETLICL-NGTrpsWNGETPSC 275
Cdd:cd00033    1 CPPPPVPENGTVtgSKGSYSYGSTVTYSCNEGYTLVGSSTITCTeNGG---WSPPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 595-765 7.24e-10

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 61.22  E-value: 7.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 595 GTVLTYQCEPGYELLGSDILTCQWDLS---WSAAPPACQkIMTCADPGEIANGHRTASDAGFPVGSHVQYRCLP----GY 667
Cdd:PHA02639  43 GKLIEYTCNTDYALIGDRFRTCIKDKNnaiWSNKAPFCM-LKECNDPPSIINGKIYNKREMYKVGDEIYYVCNEhkgvQY 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 668 SLEGAAMLTCysrdTGTPKWSDRVPKCalKYEPCLNPGVPE---NGYQTLYKHHYQAgeSLRFFCYEGFELIGEVTITCv 744
Cdd:PHA02639 122 SLVGNEKITC----IQDKSWKPDPPIC--KMINCRFPALQNgyiNGIPSNKKFYYKT--RVGFSCKSGFDLVGEKYSTC- 192

                        170       180
                 ....*....|....*....|.
gi 166235138 745 pGHPSQWTSQPPLCKVTQTTD 765
Cdd:PHA02639 193 -NINATWFPSIPTCVRNKPID 212
PHA02831 PHA02831
EEV host range protein; Provisional
 598-758 9.70e-10

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 60.39  E-value: 9.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 598 LTYQCEPGYEllgSDILTCQwDLSWSAAPpACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRC----LPGYSLEGAA 673
Cdd:PHA02831  46 LEYKCNNNFD---KVFVTCN-NGSWSTKN-MCIGKRNCKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNE 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 674 MLTCYSRdtgtpKWSDRVPKCAL---KYePCLnpgvpENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCvpGHPSQ 750
Cdd:PHA02831 121 TVKCINK-----QWVPKYPVCKLircKY-PAL-----QNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTC--DINSI 187


                 ....*...
gi 166235138 751 WTSQPPLC 758
Cdd:PHA02831 188 WYPGIPKC 195
Sushi pfam00084
Sushi repeat (SCR repeat);
220-275 1.95e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 51.35  E-value: 1.95e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 166235138  220 CGFPPRPAHGDVSVTD--LHPGGTATFHCDSGYQLQGEETLICLNGtrPSWNGETPSC 275
Cdd:pfam00084   1 CPPPPDIPNGKVSATKneYNYGASVSYECDPGYRLVGSPTITCQED--GTWSPPFPEC 56
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 289-347 5.95e-08

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 51.24  E-value: 5.95e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 166235138   289 GRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDN----DRLMVRSGGSPLSPVI 347
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASSPLL 63
Sushi pfam00084
Sushi repeat (SCR repeat);
635-694 7.55e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.42  E-value: 7.55e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138  635 CADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCysrdTGTPKWSDRVPKC 694
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITC----QEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
701-758 4.59e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 47.49  E-value: 4.59e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 166235138  701 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGhpSQWTSQPPLC 758
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED--GTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
394-453 2.55e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.18  E-value: 2.55e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 166235138  394 CFAPF-LAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 453
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRLV---GSPTITCQE--DGTWSPPFPEC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 643-766 7.26e-06

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 48.50  E-value: 7.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 643 NGHRTASDAGFPVGSHVQYRCLPGYSLEgaAMLTCYSRDTGTpKWSdRVPKCALKYepCLNPGVPENGYQTLYKHHYqaG 722
Cdd:PHA02927  34 NSVETDANANYNIGDTIEYLCLPGYRKQ--KMGPIYAKCTGT-GWT-LFNQCIKRR--CPSPRDIDNGQLDIGGVDF--G 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 166235138 723 ESLRFFCYEGFELIGEVTITCVPGHPSQ--WTSQPPLCKVTQTTDP 766
Cdd:PHA02927 106 SSITYSCNSGYQLIGESKSYCELGSTGSmvWNPEAPICESVKCQSP 151
PHA02817 PHA02817
EEV Host range protein; Provisional
 594-703 9.34e-06

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 47.63  E-value: 9.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 594 RGTVLTYQCEPG-----YELLGSDILTCQWDLSWSAAPPACqKIMTCADPGeIANGHRTA--SDAGFPVGSHVQYRCLPG 666
Cdd:PHA02817  44 IGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVC-KIIRCRFPA-LQNGFVNGipDSKKFYYESEVSFSCKPG 121

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 166235138 667 YSLEGAAMLTCYSRDTgtpkWSDRVPKCaLKYEPCLN 703
Cdd:PHA02817 122 FVLIGTKYSVCGINSS----WIPKVPIC-SRDNITYN 153
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 112-213 1.31e-05

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 44.69  E-value: 1.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138   112 GYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGggsPGLAPRLLAN--SSMLGEg 184
Cdd:smart00042   1 GTITSPNYPQSYPN---NLDCVWTIRAPPGYRIELQFTDFDLESSDNceydyVEIYDG---PSASSPLLGRfcGSEAPP- 73

                           90       100
                   ....*....|....*....|....*....
gi 166235138   185 QVLRSPTNRLLLHFQSPRVPRGGGFRIHY 213
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
279-347 6.06e-05

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 43.05  E-value: 6.06e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 166235138  279 CGGTIHNATlGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDED----NDRLMVRSGGSPLSPVI 347
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHdecgYDYVEIRDGPSASSPLL 72
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 595-694 6.19e-05

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 45.85  E-value: 6.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 595 GTVLTYQCEPGYELLGSDILTCQWDlSWSAAPPACQKimtCADPgEIANGhrTASDAGFPVGSHVQYRCLPGYSLEGAAM 674
Cdd:PHA02954 150 GEHITINCDVGYEVIGASYISCTAN-SWNVIPSCQQK---CDIP-SLSNG--LISGSTFSIGGVIHLSCKSGFTLTGSPS 222

                         90       100
                 ....*....|....*....|
gi 166235138 675 LTCYSrdtgtPKWSDRVPKC 694
Cdd:PHA02954 223 STCID-----GKWNPVLPIC 237
CUB pfam00431
CUB domain;
103-213 1.54e-04

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 41.90  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138  103 CNNNISEGEGYVESPDLGSPVSRtlgLLDCTYSIHVYPGYGIEIQVQTLNLSQEEE-----LLVLAGGGspglaprllAN 177
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPP---NKDCVWLIRAPPGFRVKLTFQDFELEDHDEcgydyVEIRDGPS---------AS 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 166235138  178 SSMLGE------GQVLRSPTNRLLLHFQSPRVPRGGGFRIHY 213
Cdd:pfam00431  69 SPLLGRfcgsgiPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 397-454 1.68e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.14  E-value: 1.68e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 166235138 397 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPACK 454
Cdd:cd00033    5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV---GSSTITCTE--NGGWSPPPPTCE 57
PHA02817 PHA02817
EEV Host range protein; Provisional
 635-758 2.39e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 43.39  E-value: 2.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 635 CADPGEIANGHRTASDAGFPVGSHVQYRC------LPgYSLEGAAMLTCySRDTgtpKWSDRVPKCAL---KYePCLNPG 705
Cdd:PHA02817  24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCgnntrgVR-YTLVGEKNIIC-EKDG---KWNKEFPVCKIircRF-PALQNG 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 166235138 706 VPeNGYQTLYKHHYQagESLRFFCYEGFELIGEVTITCvpGHPSQWTSQPPLC 758
Cdd:PHA02817  98 FV-NGIPDSKKFYYE--SEVSFSCKPGFVLIGTKYSVC--GINSSWIPKVPIC 145
PHA02817 PHA02817
EEV Host range protein; Provisional
 694-769 5.79e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 42.24  E-value: 5.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166235138 694 CALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEG-----FELIGEVTITCvpGHPSQWTSQPPLCKVTQTTDPSR 768
Cdd:PHA02817  17 SLCDLNKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIIC--EKDGKWNKEFPVCKIIRCRFPAL 94


                 .
gi 166235138 769 Q 769
Cdd:PHA02817  95 Q 95
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 397-453 6.73e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.28  E-value: 6.73e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 166235138   397 PFLAHGNVTTTDPEYRPGALATFSCLPGYALEppgPPNAIECVDptEPHWNDTEPAC 453
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLI---GSSTITCLE--NGTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 206-275 1.97e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 40.79  E-value: 1.97e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 166235138 206 GGGFRIHYQAYLLSCGFPPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPS--WNGETPSC 275
Cdd:PHA02927  72 GTGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDFGSSITYSCNSGYQLIGESKSYCELGSTGSmvWNPEAPIC 143
PHA02831 PHA02831
EEV host range protein; Provisional
 701-769 2.04e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 40.75  E-value: 2.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 166235138 701 CLNPGVPENGYQTLYKHHYQAGESLRFFC----YEGFELIGEVTITCVPGhpsQWTSQPPLCKVTQTTDPSRQ 769
Cdd:PHA02831  78 CKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNETVKCINK---QWVPKYPVCKLIRCKYPALQ 147
PHA02639 PHA02639
EEV host range protein; Provisional
 701-772 4.20e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 40.03  E-value: 4.20e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 166235138 701 CLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPG-HPSQWTSQPPLCKVTQTTDPSRQLEG 772
Cdd:PHA02639  22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDkNNAIWSNKAPFCMLKECNDPPSIING 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH