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Conserved domains on  [gi|156616310|ref|NP_001096081|]
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SET and MYND domain-containing protein 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 418-598 3.00e-68

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


:

Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 224.48  E-value: 3.00e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 418 KYGSNYNAIFSLLPHTEKHSPEHRFICAISVSALCRQLkadsvQAQTLKSPKLKAVTPGLCADLTVWGAAMLRHMLQLQC 497
Cdd:cd10536   44 PYSSDYRSVYNLVTHTENRSPEDLFQRALTAVFLAKCL-----QLSGYFLLWEASTELNGEEPESILGGLLLRHLQQLQC 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 498 NAQAITSICHTGSNESIITNSrQIRLATGIFPVVSLLNHSCRPNTSVSFTGTVATVRAAQRIAKGQEILHCYGPHESRMG 577
Cdd:cd10536  119 NAHAITELQTTSSGSQVDTSK-QVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITICYGPHFSRMK 197

                        170       180
                 ....*....|....*....|.
gi 156616310 578 VAERQQRLSSQYFFDCRCGAC 598
Cdd:cd10536  198 RSERQRLLKEQYFFDCSCEAC 218
zf-MYND pfam01753
MYND finger;
296-335 6.70e-10

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 54.73  E-value: 6.70e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 156616310  296 CHRCLKHTLATVPCGSCSYAKYCSQECMQQAWdLYHSTEC 335
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
3a0801s09 super family cl36792
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 39-211 3.33e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00990:

Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 47.29  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310   39 PSSSLLQPEDEMFLKELSS--SYSVEKDNDAPLFYREEGNRKFQEKEYTDAAVLYSKGVShSRPNtediSLCYANRSAAL 116
Cdd:TIGR00990  96 PKNAPVEPADELPEIDESSvaNLSEEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIE-CKPD----PVYYSNRAACH 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310  117 FHLGQYEACLKDIVEAgmhgypERLQP---KMMVRKTECLVNLGRLQEArqtISDLESSLTAKPTLVLSSYQILQRNVQH 193
Cdd:TIGR00990 171 NALGDWEKVVEDTTAA------LELDPdysKALNRRANAYDGLGKYADA---LLDLTASCIIDGFRNEQSAQAVERLLKK 241

                         170       180
                  ....*....|....*....|
gi 156616310  194 LKI-KIQEK-ETLPEPIPAA 211
Cdd:TIGR00990 242 FAEsKAKEIlETKPENLPSV 261
TPR_12 pfam13424
Tetratricopeptide repeat;
655-725 3.46e-05

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.76  E-value: 3.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156616310  655 QVCMAQKLLRTGKPEQAIQQLLRCREAAESFLSAEHTVLGEIEDGLAQAHATLGNWLKSAAHVQKSLQVVE 725
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 243-299 6.38e-03

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd20071:

Pssm-ID: 394802 [Multi-domain]  Cd Length: 122  Bit Score: 37.36  E-value: 6.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156616310 243 KGRHLVATKDILPGELLVKEDAFVSVlipgemprPHHCLENKWDTRVTSGDLYC------HRC 299
Cdd:cd20071    9 KGRGLVATRDIEPGELILVEKPLVSV--------PSNSFSLTDGLNEIGVGLFPlasllnHSC 63
 
Name Accession Description Interval E-value
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 418-598 3.00e-68

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 224.48  E-value: 3.00e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 418 KYGSNYNAIFSLLPHTEKHSPEHRFICAISVSALCRQLkadsvQAQTLKSPKLKAVTPGLCADLTVWGAAMLRHMLQLQC 497
Cdd:cd10536   44 PYSSDYRSVYNLVTHTENRSPEDLFQRALTAVFLAKCL-----QLSGYFLLWEASTELNGEEPESILGGLLLRHLQQLQC 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 498 NAQAITSICHTGSNESIITNSrQIRLATGIFPVVSLLNHSCRPNTSVSFTGTVATVRAAQRIAKGQEILHCYGPHESRMG 577
Cdd:cd10536  119 NAHAITELQTTSSGSQVDTSK-QVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITICYGPHFSRMK 197

                        170       180
                 ....*....|....*....|.
gi 156616310 578 VAERQQRLSSQYFFDCRCGAC 598
Cdd:cd10536  198 RSERQRLLKEQYFFDCSCEAC 218
zf-MYND pfam01753
MYND finger;
296-335 6.70e-10

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 54.73  E-value: 6.70e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 156616310  296 CHRCLKHTLATVPCGSCSYAKYCSQECMQQAWdLYHSTEC 335
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 524-570 1.71e-07

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 50.21  E-value: 1.71e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 156616310  524 ATGIFPVVSLLNHSCRPNTSVSF----TGTVATVRAAQRIAKGQEILHCYG 570
Cdd:pfam00856  65 ALYYGNWARFINHSCDPNCEVRVvyvnGGPRIVIFALRDIKPGEELTIDYG 115
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 524-571 5.93e-06

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 46.17  E-value: 5.93e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 156616310   524 ATGIFPVVSLLNHSCRPNTSVSF----TGTVATVRAAQRIAKGQEILHCYGP 571
Cdd:smart00317  68 ARRKGNLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGEELTIDYGS 119
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
532-599 1.44e-05

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 45.34  E-value: 1.44e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 532 SLLNHSCRPNTSVSFTGTVATVRAAQRIAKGQEILHCYG--PHESRmgvaerqqrlssqyfFDCRCGACH 599
Cdd:COG2940   78 RFINHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDYGldYDEEE---------------YPCRCPNCR 132
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 39-211 3.33e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 47.29  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310   39 PSSSLLQPEDEMFLKELSS--SYSVEKDNDAPLFYREEGNRKFQEKEYTDAAVLYSKGVShSRPNtediSLCYANRSAAL 116
Cdd:TIGR00990  96 PKNAPVEPADELPEIDESSvaNLSEEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIE-CKPD----PVYYSNRAACH 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310  117 FHLGQYEACLKDIVEAgmhgypERLQP---KMMVRKTECLVNLGRLQEArqtISDLESSLTAKPTLVLSSYQILQRNVQH 193
Cdd:TIGR00990 171 NALGDWEKVVEDTTAA------LELDPdysKALNRRANAYDGLGKYADA---LLDLTASCIIDGFRNEQSAQAVERLLKK 241

                         170       180
                  ....*....|....*....|
gi 156616310  194 LKI-KIQEK-ETLPEPIPAA 211
Cdd:TIGR00990 242 FAEsKAKEIlETKPENLPSV 261
TPR_12 pfam13424
Tetratricopeptide repeat;
655-725 3.46e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.76  E-value: 3.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156616310  655 QVCMAQKLLRTGKPEQAIQQLLRCREAAESFLSAEHTVLGEIEDGLAQAHATLGNWLKSAAHVQKSLQVVE 725
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
51-211 1.87e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.67  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310  51 FLKELSSSYSVEKDNDAPLFYrEEGNRKFQEKEYTDAAVLYSKGVSHsRPnteDISLCYANRSAALFHLGQYEACLKDIV 130
Cdd:COG4785   57 ALAAERIDRALALPDLAQLYY-ERGVAYDSLGDYDLAIADFDQALEL-DP---DLAEAYNNRGLAYLLLGDYDAALEDFD 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 131 EAGmhgypeRLQPKM---MVRKTECLVNLGRLQEArqtISDLESSLTAKPTLVlssYQILQRNVQHLKIKIQE-KETLPE 206
Cdd:COG4785  132 RAL------ELDPDYayaYLNRGIALYYLGRYELA---IADLEKALELDPNDP---ERALWLYLAERKLDPEKaLALLLE 199


                 ....*
gi 156616310 207 PIPAA 211
Cdd:COG4785  200 DWATA 204
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 243-299 6.38e-03

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 37.36  E-value: 6.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156616310 243 KGRHLVATKDILPGELLVKEDAFVSVlipgemprPHHCLENKWDTRVTSGDLYC------HRC 299
Cdd:cd20071    9 KGRGLVATRDIEPGELILVEKPLVSV--------PSNSFSLTDGLNEIGVGLFPlasllnHSC 63
 
Name Accession Description Interval E-value
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 418-598 3.00e-68

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 224.48  E-value: 3.00e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 418 KYGSNYNAIFSLLPHTEKHSPEHRFICAISVSALCRQLkadsvQAQTLKSPKLKAVTPGLCADLTVWGAAMLRHMLQLQC 497
Cdd:cd10536   44 PYSSDYRSVYNLVTHTENRSPEDLFQRALTAVFLAKCL-----QLSGYFLLWEASTELNGEEPESILGGLLLRHLQQLQC 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 498 NAQAITSICHTGSNESIITNSrQIRLATGIFPVVSLLNHSCRPNTSVSFTGTVATVRAAQRIAKGQEILHCYGPHESRMG 577
Cdd:cd10536  119 NAHAITELQTTSSGSQVDTSK-QVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITICYGPHFSRMK 197

                        170       180
                 ....*....|....*....|.
gi 156616310 578 VAERQQRLSSQYFFDCRCGAC 598
Cdd:cd10536  198 RSERQRLLKEQYFFDCSCEAC 218
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 513-598 2.88e-22

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 92.83  E-value: 2.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 513 SIITNSRQIRLATGIFPVVSLLNHSCRPNTSVSFTGT-VATVRAAQRIAKGQEILHCYGPHEsrMGVAERQQRLSSQYFF 591
Cdd:cd20071   38 SFSLTDGLNEIGVGLFPLASLLNHSCDPNAVVVFDGNgTLRVRALRDIKAGEELTISYIDPL--LPRTERRRELLEKYGF 115


                 ....*..
gi 156616310 592 DCRCGAC 598
Cdd:cd20071  116 TCSCPRC 122
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 510-598 1.32e-20

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 90.56  E-value: 1.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 510 SNESIITNSRQIRLATGIFPVVSLLNHSCRPNTSVSFTGTVATVRAAQRIAKGQEILHCYGPheSRMGVAERQQRLSSQY 589
Cdd:cd19167  117 CNGFTISDEELQHVGVGIYPQAALLNHSCCPNCIVTFNGPNIEVRAVQEIEPGEEVFHSYID--LLYPTEERRDQLRDQY 194


                 ....*....
gi 156616310 590 FFDCRCGAC 598
Cdd:cd19167  195 FFLCQCADC 203
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 486-598 2.11e-17

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 81.64  E-value: 2.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 486 AAMLRHMLQ--LQCNAQAITS------ICHTGSNESIITNSRQIRLATGIFPVVSLLNHSCRPNTSVSFTGTVATVRAAQ 557
Cdd:cd19203   90 AMVLQHYLReeIQDASQLPPAfdifelFAKVTCNSFTICDAEMQEVGVGLYPSASLLNHSCDPNCVIVFNGPHLLLRAIR 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 156616310 558 RIAKGQEILHCYgpHESRMGVAERQQRLSSQYFFDCRCGAC 598
Cdd:cd19203  170 EIEVGEELTISY--IDMLMPSEERRKQLRDQYCFECDCFRC 208
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
 523-598 1.87e-14

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 72.93  E-value: 1.87e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156616310 523 LATGIFPVVSLLNHSCRPNTSVSFTGTVATVRAAQRIAKGQEILHCYgpHESRMGVAERQQRLSSQYFFDCRCGAC 598
Cdd:cd19202  131 LGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY--IDLLYPTEDRNDRLRDSYFFTCECQEC 204
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 523-598 1.25e-11

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 64.74  E-value: 1.25e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156616310 523 LATGIFPVVSLLNHSCRPNTSVSFTGTVATVRAAQRIAKGQEILHCYgpHESRMGVAERQQRLSSQYFFDCRCGAC 598
Cdd:cd10526  135 VGVGIFPNLCLVNHDCWPNCTVIFNNGRIELRALGKISEGDELTVSY--IDFLNTSEDRKEQLKKQYYFDCTCEHC 208
zf-MYND pfam01753
MYND finger;
296-335 6.70e-10

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 54.73  E-value: 6.70e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 156616310  296 CHRCLKHTLATVPCGSCSYAKYCSQECMQQAWdLYHSTEC 335
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 526-601 4.68e-09

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 58.47  E-value: 4.68e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 156616310 526 GIFPVVSLLNHSCRPNTSVSFTGTVAT--VRAAQRIAKGQEILHCYGPHESR-MGVAERQQRLSSQYFFDCRCGACHAE 601
Cdd:cd10521  204 GLYLLQSCCNHSCVPNAEITFPENNFTlsLKALRDIQEGEEICISYLDECQReRSRHSRQKILRENYLFICNCPKCEAQ 282
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 524-570 1.71e-07

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 50.21  E-value: 1.71e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 156616310  524 ATGIFPVVSLLNHSCRPNTSVSF----TGTVATVRAAQRIAKGQEILHCYG 570
Cdd:pfam00856  65 ALYYGNWARFINHSCDPNCEVRVvyvnGGPRIVIFALRDIKPGEELTIDYG 115
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 524-571 5.93e-06

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 46.17  E-value: 5.93e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 156616310   524 ATGIFPVVSLLNHSCRPNTSVSF----TGTVATVRAAQRIAKGQEILHCYGP 571
Cdd:smart00317  68 ARRKGNLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGEELTIDYGS 119
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
532-599 1.44e-05

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 45.34  E-value: 1.44e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 532 SLLNHSCRPNTSVSFTGTVATVRAAQRIAKGQEILHCYG--PHESRmgvaerqqrlssqyfFDCRCGACH 599
Cdd:COG2940   78 RFINHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDYGldYDEEE---------------YPCRCPNCR 132
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 39-211 3.33e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 47.29  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310   39 PSSSLLQPEDEMFLKELSS--SYSVEKDNDAPLFYREEGNRKFQEKEYTDAAVLYSKGVShSRPNtediSLCYANRSAAL 116
Cdd:TIGR00990  96 PKNAPVEPADELPEIDESSvaNLSEEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIE-CKPD----PVYYSNRAACH 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310  117 FHLGQYEACLKDIVEAgmhgypERLQP---KMMVRKTECLVNLGRLQEArqtISDLESSLTAKPTLVLSSYQILQRNVQH 193
Cdd:TIGR00990 171 NALGDWEKVVEDTTAA------LELDPdysKALNRRANAYDGLGKYADA---LLDLTASCIIDGFRNEQSAQAVERLLKK 241

                         170       180
                  ....*....|....*....|
gi 156616310  194 LKI-KIQEK-ETLPEPIPAA 211
Cdd:TIGR00990 242 FAEsKAKEIlETKPENLPSV 261
TPR_12 pfam13424
Tetratricopeptide repeat;
655-725 3.46e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.76  E-value: 3.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156616310  655 QVCMAQKLLRTGKPEQAIQQLLRCREAAESFLSAEHTVLGEIEDGLAQAHATLGNWLKSAAHVQKSLQVVE 725
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 529-572 1.26e-04

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 44.36  E-value: 1.26e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 156616310 529 PVVSLLNHS-CRPNTSVSFTGTVAT--VRAAQRIAKGQEILHCYGPH 572
Cdd:cd10527  178 PLADMLNHSpDAPNVRYEYDEDEGSfvLVATRDIAAGEEVFISYGPK 224
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
 529-572 2.47e-04

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 43.44  E-value: 2.47e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 156616310 529 PVVSLLNHSCRPNTSVSFTGTVA--TVRAAQRIAKGQEILHCYGPH 572
Cdd:cd19177  187 PFLDLLNHSPDVNVKAGFNKSGKcyEIRTGTDYKKGEEVFISYGPH 232
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 532-572 9.24e-04

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 39.54  E-value: 9.24e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 156616310 532 SLLNHSCRPNTSVS--FTGTVATVRAAQRIAKGQEILHCYGPH 572
Cdd:cd10540   67 SMFNHSYTPNAEYEidFENQTIVFYALRDIEAGEELTINYGDD 109
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
51-211 1.87e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.67  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310  51 FLKELSSSYSVEKDNDAPLFYrEEGNRKFQEKEYTDAAVLYSKGVSHsRPnteDISLCYANRSAALFHLGQYEACLKDIV 130
Cdd:COG4785   57 ALAAERIDRALALPDLAQLYY-ERGVAYDSLGDYDLAIADFDQALEL-DP---DLAEAYNNRGLAYLLLGDYDAALEDFD 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156616310 131 EAGmhgypeRLQPKM---MVRKTECLVNLGRLQEArqtISDLESSLTAKPTLVlssYQILQRNVQHLKIKIQE-KETLPE 206
Cdd:COG4785  132 RAL------ELDPDYayaYLNRGIALYYLGRYELA---IADLEKALELDPNDP---ERALWLYLAERKLDPEKaLALLLE 199


                 ....*
gi 156616310 207 PIPAA 211
Cdd:COG4785  200 DWATA 204
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 531-598 3.42e-03

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 38.42  E-value: 3.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156616310 531 VSLLNHSCRPNTS-VSFTGTVATVRAAQRIAKGQEILHCYGPHesrmgvaerqqrlssqYFF----DCRCGAC 598
Cdd:cd10524   77 AAFINHDCRPNCKfVPTGKSTACVKVLRDIEPGEEITVYYGDN----------------YFGenneECECETC 133
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 535-570 3.58e-03

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 36.85  E-value: 3.58e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 156616310 535 NHSCRPNTSVSFTGT----VATVRAAQRIAKGQEILHCYG 570
Cdd:cd08161   33 NHSCEPNCEFEEVYVggkpRVFIVALRDIKAGEELTVDYG 72
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 243-299 6.38e-03

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 37.36  E-value: 6.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156616310 243 KGRHLVATKDILPGELLVKEDAFVSVlipgemprPHHCLENKWDTRVTSGDLYC------HRC 299
Cdd:cd20071    9 KGRGLVATRDIEPGELILVEKPLVSV--------PSNSFSLTDGLNEIGVGLFPlasllnHSC 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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