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Conserved domains on  [gi|153281205|ref|NP_001093134|]
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neuropeptide W preproprotein [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPBW super family cl21045
Neuropeptides B and W; The function of this family, NPBW, which includes Neuropeptides B and W, ...
 34-140 7.78e-28

Neuropeptides B and W; The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.


The actual alignment was detected with superfamily member pfam15180:

Pssm-ID: 464547  Cd Length: 118  Bit Score: 100.54  E-value: 7.78e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153281205   34 ASAWYKHVASPRYHTVGRASGLLMGLRRSPYQWRRALGGAAGPLSR---LPGPVARGAL-LLPSSGQELWEVRSRsspag 109
Cdd:pfam15180  16 AEAWYKQAAGPSYYSVGRASGLLSGIRRSPYARRSEPEGAAGPLEGagaAPEPRQRSSLrSLAVCVKDVSPNLQS----- 90

                          90       100       110
                  ....*....|....*....|....*....|...
gi 153281205  110 lpvhaPWSPRDLEGVRQ--PEQSLSLHSWISEE 140
Cdd:pfam15180  91 -----CELLQDGRGTFQckADVFLSLDSADCAS 118
 
Name Accession Description Interval E-value
NPBW pfam15180
Neuropeptides B and W; The function of this family, NPBW, which includes Neuropeptides B and W, ...
 34-140 7.78e-28

Neuropeptides B and W; The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.


Pssm-ID: 464547  Cd Length: 118  Bit Score: 100.54  E-value: 7.78e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153281205   34 ASAWYKHVASPRYHTVGRASGLLMGLRRSPYQWRRALGGAAGPLSR---LPGPVARGAL-LLPSSGQELWEVRSRsspag 109
Cdd:pfam15180  16 AEAWYKQAAGPSYYSVGRASGLLSGIRRSPYARRSEPEGAAGPLEGagaAPEPRQRSSLrSLAVCVKDVSPNLQS----- 90

                          90       100       110
                  ....*....|....*....|....*....|...
gi 153281205  110 lpvhaPWSPRDLEGVRQ--PEQSLSLHSWISEE 140
Cdd:pfam15180  91 -----CELLQDGRGTFQckADVFLSLDSADCAS 118
 
Name Accession Description Interval E-value
NPBW pfam15180
Neuropeptides B and W; The function of this family, NPBW, which includes Neuropeptides B and W, ...
 34-140 7.78e-28

Neuropeptides B and W; The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.


Pssm-ID: 464547  Cd Length: 118  Bit Score: 100.54  E-value: 7.78e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153281205   34 ASAWYKHVASPRYHTVGRASGLLMGLRRSPYQWRRALGGAAGPLSR---LPGPVARGAL-LLPSSGQELWEVRSRsspag 109
Cdd:pfam15180  16 AEAWYKQAAGPSYYSVGRASGLLSGIRRSPYARRSEPEGAAGPLEGagaAPEPRQRSSLrSLAVCVKDVSPNLQS----- 90

                          90       100       110
                  ....*....|....*....|....*....|...
gi 153281205  110 lpvhaPWSPRDLEGVRQ--PEQSLSLHSWISEE 140
Cdd:pfam15180  91 -----CELLQDGRGTFQckADVFLSLDSADCAS 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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