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Conserved domains on  [gi|133904140|ref|NP_001076587|]
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telomeric repeat-binding factor 2 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRFH cd00280
Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain ...
 90-289 2.46e-111

Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, protecting the chromosome ends from degradation and end-to-end fusion. Proteins TRF1, TRF2 and Taz1 bind telomeric DNA and are also involved in recruiting interacting proteins, TIN2, and Rap1, to the telomeres. It has also been demonstrated that PARP1 associates with TRF2 and is capable of poly(ADP-ribosyl)ation of TRF2, which affects binding of TRF2 to telomeric DNA. TRF1, TRF2 and Taz1 proteins contain three functional domains: an N-terminal acidic domain, a central TRF-specific/dimerization domain, and a C-terminal DNA binding domain with a single Myb-like repeat. Homodimerization, a prerequisite to DNA binding, results in the juxtaposition of two Myb DNA binding domains.


:

Pssm-ID: 238174  Cd Length: 200  Bit Score: 327.10  E-value: 2.46e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133904140  90 EARLEEAVNRWVLKFYFHEALRAFRSSRYRDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEA 169
Cdd:cd00280    1 EADAEAVANRWVLDFYFHSACRAFREGRYEDFRRTRDIAEALLVGPLKLTATQLKTLRIMQFLSRIAEGKNLDCQFENDE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133904140 170 ELTPLESAINVLEMIKTEFTLTDSMVESSRKLVKEAAVIICIKNKEFEKASKILKKYMSkDPTTQKLRTDLLNIIREKNL 249
Cdd:cd00280   81 ELTPLESALMVLESIEKEFSLPETLHEEIRKLIKEQAVAVCMENGEFKKAEEVLKRLFS-DPESQKLRMKLLMIIREKDP 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 133904140 250 AHPVIQNFSYEVFQQKMLRFLESHLDDTE-PYLLTMAKKAL 289
Cdd:cd00280  160 AHPVLQNFSYSHFMQKMKSYVELVLDEKEsPFLLKAAAKVV 200
TRF2_RBM cd11654
RAP1 binding motif of telomere repeat binding factor; TRF2 (Telomere repeat binding factor 2) ...
 319-359 2.79e-16

RAP1 binding motif of telomere repeat binding factor; TRF2 (Telomere repeat binding factor 2) functions as part of the 6-component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminus (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA-binding proteins (TRF2, TRF1 and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM) described by this model, the TIN2 binding motif (TBM), and a myb-like DNA binding domain.


:

Pssm-ID: 212553  Cd Length: 42  Bit Score: 72.41  E-value: 2.79e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 133904140 319 QPQNPPATIGIRTLKAAFKALSTAQDSEAAFAKLDQKDLVL 359
Cdd:cd11654    1 QPVSTPTTIGISTLKAAFKSLSQAEDSDAAFAKLDQKDLVR 41
 
Name Accession Description Interval E-value
TRFH cd00280
Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain ...
 90-289 2.46e-111

Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, protecting the chromosome ends from degradation and end-to-end fusion. Proteins TRF1, TRF2 and Taz1 bind telomeric DNA and are also involved in recruiting interacting proteins, TIN2, and Rap1, to the telomeres. It has also been demonstrated that PARP1 associates with TRF2 and is capable of poly(ADP-ribosyl)ation of TRF2, which affects binding of TRF2 to telomeric DNA. TRF1, TRF2 and Taz1 proteins contain three functional domains: an N-terminal acidic domain, a central TRF-specific/dimerization domain, and a C-terminal DNA binding domain with a single Myb-like repeat. Homodimerization, a prerequisite to DNA binding, results in the juxtaposition of two Myb DNA binding domains.


Pssm-ID: 238174  Cd Length: 200  Bit Score: 327.10  E-value: 2.46e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133904140  90 EARLEEAVNRWVLKFYFHEALRAFRSSRYRDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEA 169
Cdd:cd00280    1 EADAEAVANRWVLDFYFHSACRAFREGRYEDFRRTRDIAEALLVGPLKLTATQLKTLRIMQFLSRIAEGKNLDCQFENDE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133904140 170 ELTPLESAINVLEMIKTEFTLTDSMVESSRKLVKEAAVIICIKNKEFEKASKILKKYMSkDPTTQKLRTDLLNIIREKNL 249
Cdd:cd00280   81 ELTPLESALMVLESIEKEFSLPETLHEEIRKLIKEQAVAVCMENGEFKKAEEVLKRLFS-DPESQKLRMKLLMIIREKDP 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 133904140 250 AHPVIQNFSYEVFQQKMLRFLESHLDDTE-PYLLTMAKKAL 289
Cdd:cd00280  160 AHPVLQNFSYSHFMQKMKSYVELVLDEKEsPFLLKAAAKVV 200
TRF pfam08558
Telomere repeat binding factor (TRF); Telomere repeat binding factor (TRF) family proteins are ...
 100-267 8.73e-40

Telomere repeat binding factor (TRF); Telomere repeat binding factor (TRF) family proteins are important for the regulation of telomere stability. The two related human TRF proteins hTRF1 and hTRF2 form homodimers and bind directly to telomeric TTAGGG repeats via the myb DNA binding domain pfam00249 at the carboxy terminus. TRF1 is implicated in telomere length regulation and TRF2 in telomere protection. Other telomere complex associated proteins are recruited through their interaction with either TRF1 or TRF2. The fission yeast protein Taz1p (telomere-associated in Schizosaccharomyces pombe) has similarity to both hTRF1 and hTRF2 and may perform the dual functions of TRF1 and TRF2 at fission yeast telomeres. This domain is composed of multiple alpha helices arranged in a solenoid conformation similar to TPR repeats. The fungal members have now also been found to carry two double strand telomeric repeat binding factors.


Pssm-ID: 400735  Cd Length: 212  Bit Score: 142.54  E-value: 8.73e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133904140  100 WVLKFYFHEALRAFRSSRYR-----------DFRQIRDIMQALLVRPLGKEHTVSRLLR----------VMQCLSRIEEG 158
Cdd:pfam08558   3 WVLDNLSTQLLRALREGPYTdvlaivsepdsEFRESFDILESLFERTKKLYSTRSPLLSpsilkiresyIMQTLRRINLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133904140  159 ENLDCSFDMEaELTPLESAINVLEMIKTEftlTDSMVESSRKL---VKEAAVIICIKNKEFEKASKILKKYMSKDPTT-- 233
Cdd:pfam08558  83 TFLDSVFGNL-EVGFLELAENFLDIFCPE---DGKLLKPQGVLyldLKTQAYIVALKEGPFKSASEILDKLFPDDLADil 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 133904140  234 -------------------QKLRTDLLNIIREKNLAHPVIQNFSYEVFQQKML 267
Cdd:pfam08558 159 kqrndklltpsetdfvercKKRREKLLNIINEKDPYHPLLQNFSWESFLKELL 211
TRF2_RBM cd11654
RAP1 binding motif of telomere repeat binding factor; TRF2 (Telomere repeat binding factor 2) ...
 319-359 2.79e-16

RAP1 binding motif of telomere repeat binding factor; TRF2 (Telomere repeat binding factor 2) functions as part of the 6-component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminus (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA-binding proteins (TRF2, TRF1 and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM) described by this model, the TIN2 binding motif (TBM), and a myb-like DNA binding domain.


Pssm-ID: 212553  Cd Length: 42  Bit Score: 72.41  E-value: 2.79e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 133904140 319 QPQNPPATIGIRTLKAAFKALSTAQDSEAAFAKLDQKDLVL 359
Cdd:cd11654    1 QPVSTPTTIGISTLKAAFKSLSQAEDSDAAFAKLDQKDLVR 41
TERF2_RBM pfam16772
Telomeric repeat-binding factor 2 Rap1-binding motif; This domain, found in telomeric ...
 320-359 5.34e-15

Telomeric repeat-binding factor 2 Rap1-binding motif; This domain, found in telomeric repeat-binding factor 2, binds to the C-terminus of repressor activator protein 1 (RAP1) (telomeric repeat-binding factor 2-interacting protein 1).


Pssm-ID: 435576  Cd Length: 41  Bit Score: 68.60  E-value: 5.34e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 133904140  320 PQNPPATIGIRTLKAAFKALSTAQDSEAAFAKLDQKDLVL 359
Cdd:pfam16772   1 PPETPTTYGISVLKAAFKSLSDSQDPDAAFTKLDETDLTL 40
 
Name Accession Description Interval E-value
TRFH cd00280
Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain ...
 90-289 2.46e-111

Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, protecting the chromosome ends from degradation and end-to-end fusion. Proteins TRF1, TRF2 and Taz1 bind telomeric DNA and are also involved in recruiting interacting proteins, TIN2, and Rap1, to the telomeres. It has also been demonstrated that PARP1 associates with TRF2 and is capable of poly(ADP-ribosyl)ation of TRF2, which affects binding of TRF2 to telomeric DNA. TRF1, TRF2 and Taz1 proteins contain three functional domains: an N-terminal acidic domain, a central TRF-specific/dimerization domain, and a C-terminal DNA binding domain with a single Myb-like repeat. Homodimerization, a prerequisite to DNA binding, results in the juxtaposition of two Myb DNA binding domains.


Pssm-ID: 238174  Cd Length: 200  Bit Score: 327.10  E-value: 2.46e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133904140  90 EARLEEAVNRWVLKFYFHEALRAFRSSRYRDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEA 169
Cdd:cd00280    1 EADAEAVANRWVLDFYFHSACRAFREGRYEDFRRTRDIAEALLVGPLKLTATQLKTLRIMQFLSRIAEGKNLDCQFENDE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133904140 170 ELTPLESAINVLEMIKTEFTLTDSMVESSRKLVKEAAVIICIKNKEFEKASKILKKYMSkDPTTQKLRTDLLNIIREKNL 249
Cdd:cd00280   81 ELTPLESALMVLESIEKEFSLPETLHEEIRKLIKEQAVAVCMENGEFKKAEEVLKRLFS-DPESQKLRMKLLMIIREKDP 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 133904140 250 AHPVIQNFSYEVFQQKMLRFLESHLDDTE-PYLLTMAKKAL 289
Cdd:cd00280  160 AHPVLQNFSYSHFMQKMKSYVELVLDEKEsPFLLKAAAKVV 200
TRF pfam08558
Telomere repeat binding factor (TRF); Telomere repeat binding factor (TRF) family proteins are ...
 100-267 8.73e-40

Telomere repeat binding factor (TRF); Telomere repeat binding factor (TRF) family proteins are important for the regulation of telomere stability. The two related human TRF proteins hTRF1 and hTRF2 form homodimers and bind directly to telomeric TTAGGG repeats via the myb DNA binding domain pfam00249 at the carboxy terminus. TRF1 is implicated in telomere length regulation and TRF2 in telomere protection. Other telomere complex associated proteins are recruited through their interaction with either TRF1 or TRF2. The fission yeast protein Taz1p (telomere-associated in Schizosaccharomyces pombe) has similarity to both hTRF1 and hTRF2 and may perform the dual functions of TRF1 and TRF2 at fission yeast telomeres. This domain is composed of multiple alpha helices arranged in a solenoid conformation similar to TPR repeats. The fungal members have now also been found to carry two double strand telomeric repeat binding factors.


Pssm-ID: 400735  Cd Length: 212  Bit Score: 142.54  E-value: 8.73e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133904140  100 WVLKFYFHEALRAFRSSRYR-----------DFRQIRDIMQALLVRPLGKEHTVSRLLR----------VMQCLSRIEEG 158
Cdd:pfam08558   3 WVLDNLSTQLLRALREGPYTdvlaivsepdsEFRESFDILESLFERTKKLYSTRSPLLSpsilkiresyIMQTLRRINLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133904140  159 ENLDCSFDMEaELTPLESAINVLEMIKTEftlTDSMVESSRKL---VKEAAVIICIKNKEFEKASKILKKYMSKDPTT-- 233
Cdd:pfam08558  83 TFLDSVFGNL-EVGFLELAENFLDIFCPE---DGKLLKPQGVLyldLKTQAYIVALKEGPFKSASEILDKLFPDDLADil 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 133904140  234 -------------------QKLRTDLLNIIREKNLAHPVIQNFSYEVFQQKML 267
Cdd:pfam08558 159 kqrndklltpsetdfvercKKRREKLLNIINEKDPYHPLLQNFSWESFLKELL 211
TRF2_RBM cd11654
RAP1 binding motif of telomere repeat binding factor; TRF2 (Telomere repeat binding factor 2) ...
 319-359 2.79e-16

RAP1 binding motif of telomere repeat binding factor; TRF2 (Telomere repeat binding factor 2) functions as part of the 6-component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminus (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA-binding proteins (TRF2, TRF1 and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM) described by this model, the TIN2 binding motif (TBM), and a myb-like DNA binding domain.


Pssm-ID: 212553  Cd Length: 42  Bit Score: 72.41  E-value: 2.79e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 133904140 319 QPQNPPATIGIRTLKAAFKALSTAQDSEAAFAKLDQKDLVL 359
Cdd:cd11654    1 QPVSTPTTIGISTLKAAFKSLSQAEDSDAAFAKLDQKDLVR 41
TERF2_RBM pfam16772
Telomeric repeat-binding factor 2 Rap1-binding motif; This domain, found in telomeric ...
 320-359 5.34e-15

Telomeric repeat-binding factor 2 Rap1-binding motif; This domain, found in telomeric repeat-binding factor 2, binds to the C-terminus of repressor activator protein 1 (RAP1) (telomeric repeat-binding factor 2-interacting protein 1).


Pssm-ID: 435576  Cd Length: 41  Bit Score: 68.60  E-value: 5.34e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 133904140  320 PQNPPATIGIRTLKAAFKALSTAQDSEAAFAKLDQKDLVL 359
Cdd:pfam16772   1 PPETPTTYGISVLKAAFKSLSDSQDPDAAFTKLDETDLTL 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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