NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|313151240|ref|NP_001074921|]
View 

uncharacterized protein LOC100009614 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-94 1.20e-04

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 39.39  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313151240    7 SSGCQPSCCVSSPCQPSCCVSNPCQSSCCVSSSCQSACCRPAICIPVRYQVACCVPVSCRPTVCMAPSCQSSVCMPVSCR 86
Cdd:pfam01500  65 TSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCG 144


                  ....*...
gi 313151240   87 PVCVTSSC 94
Cdd:pfam01500 145 QSCCRPAC 152
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-94 1.20e-04

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 39.39  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313151240    7 SSGCQPSCCVSSPCQPSCCVSNPCQSSCCVSSSCQSACCRPAICIPVRYQVACCVPVSCRPTVCMAPSCQSSVCMPVSCR 86
Cdd:pfam01500  65 TSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCG 144


                  ....*...
gi 313151240   87 PVCVTSSC 94
Cdd:pfam01500 145 QSCCRPAC 152
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-94 1.20e-04

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 39.39  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313151240    7 SSGCQPSCCVSSPCQPSCCVSNPCQSSCCVSSSCQSACCRPAICIPVRYQVACCVPVSCRPTVCMAPSCQSSVCMPVSCR 86
Cdd:pfam01500  65 TSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCG 144


                  ....*...
gi 313151240   87 PVCVTSSC 94
Cdd:pfam01500 145 QSCCRPAC 152
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
59-103 1.92e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 36.59  E-value: 1.92e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 313151240   59 CCVPVSCRPTVCMAPSCQSSVCMPVSCRPVCVTSSCQSSGGCQPS 103
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-119 1.77e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 35.92  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313151240    7 SSGCQPSCCVSSPCQPSCCVSnpCQSSCCVSSSCQSACCRPAICIPVRYQVACCV----------PVSCRPTVCMAPSCQ 76
Cdd:pfam01500  32 SSCCRPSCCQTSCCQPTTFQS--SCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGigygqegssgAVSSRTRWCRPDCRV 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 313151240   77 SSVCMPVSCRPVCVTSSCQSSGGCQPSCptvvCRPVTCNPSCC 119
Cdd:pfam01500 110 EGTCLPPCCVVSCTPPTCCQLHHAQASC----CRPSYCGQSCC 148
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-119 4.05e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 35.15  E-value: 4.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313151240    7 SSGCQPSCCVSSPCQPSCC---VSNPCQSSCCVSSSCQSACCRPAICIPVRYQVACCVPVSCRPTVCMAPSCQSSVCMPV 83
Cdd:pfam01500  22 SGCCQPCCCQSSCCRPSCCqtsCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTR 101

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 313151240   84 SCRPVCVTSSCQSSGGCQPSC-PTVVCRPVTCNPSCC 119
Cdd:pfam01500 102 WCRPDCRVEGTCLPPCCVVSCtPPTCCQLHHAQASCC 138
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 7-106 4.81e-03

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 34.79  E-value: 4.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313151240    7 SSGCQPSCCVSSPCQPSC------CVSNPCQSSCCVSSSCQSACCRPAICIPVRYQVACCVPVSCRPTVCMAPSCQSSVC 80
Cdd:pfam05287  73 PCTSSTSYCVPSPCQRSCysprtsCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGY 152

                          90       100
                  ....*....|....*....|....*.
gi 313151240   81 MPVSCRPVCVTSSCQSSGGCQPSCPT 106
Cdd:pfam05287 153 GSSFCRPSYVSSRSYQPSCFRPSCGS 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH