|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
1230-1779 |
4.14e-154 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 490.12 E-value: 4.14e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1230 EELIQLKAKERHFLEQLldgkKLENYKIPVPINAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhc 1309
Cdd:COG0553 211 LELLAEAAVDAFRLRRL----REALESLPAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALL----- 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1310 qraQEYARSKLAEcmplPSLVVCPPTLTGHWVDEVGKFCSReyLNPLHYTGPpTERIRLQHQVKRHNLIVASYDVVRNDI 1389
Cdd:COG0553 282 ---LELKERGLAR----PVLIVAPTSLVGNWQRELAKFAPG--LRVLVLDGT-RERAKGANPFEDADLVITSYGLLRRDI 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1390 DFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPIL 1469
Cdd:COG0553 352 ELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIE 431
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1470 ASRDArsssreqeagvlAMDALHRQVLPFLLRRMKEDVLQDLPPKIIQDYYCTLSPLQVQLYEdfaksrakcdvdeTVSS 1549
Cdd:COG0553 432 KGDEE------------ALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALYE-------------AVLE 486
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1550 AALSEETEKPKLKATGHVFQALQYLRKLCNHPALVLtpqhpefksttekltvQNSSLHDIqHAPKLSALKQLLldcglgn 1629
Cdd:COG0553 487 YLRRELEGAEGIRRRGLILAALTRLRQICSHPALLL----------------EEGAELSG-RSAKLEALLELL------- 542
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1630 gsstesgTESVVAQHRILIFCQLKSMLDIVEHDLLKPHLPsvtYLRLDGSIPPGQRHSIVSRFNNDPSIDVLLLTTHVGG 1709
Cdd:COG0553 543 -------EELLAEGEKVLVFSQFTDTLDLLEERLEERGIE---YAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGG 612
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1710 LGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQKFKMNIANTVIS 1779
Cdd:COG0553 613 EGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
1265-1502 |
3.81e-152 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 466.44 E-value: 3.81e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRAQEYarsklaECMPLPSLVVCPPTLTGHWVDEV 1344
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILASDHHKRANSF------NSENLPSLVVCPPTLVGHWVAEI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSREYLNPLHYTGPPTERIRLQHQVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTA 1424
Cdd:cd17999 75 KKYFPNAFLKPLAYVGPPQERRRLREQGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKA 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 123858774 1425 NYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLPFLLRR 1502
Cdd:cd17999 155 NHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKQVLPFLLRR 232
|
|
| DUF3535 |
pfam12054 |
Domain of unknown function (DUF3535); This presumed domain is functionally uncharacterized. ... |
585-1050 |
1.37e-121 |
|
Domain of unknown function (DUF3535); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 439 to 459 amino acids in length. This domain is found associated with pfam00271, pfam02985, pfam00176. This domain has two completely conserved residues (P and K) that may be functionally important.
Pssm-ID: 463447 Cd Length: 445 Bit Score: 390.84 E-value: 1.37e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 585 VWMELLSKA-SVQYLVAAACPWMSAWLCLMMQPSHLPIDLNMLLE--------------VKARAKEKTGGKVRQGQIQNK 649
Cdd:pfam12054 1 VWEALLRSLkPPEALLHAFCPHLSPWLTLLMTPIGVPMDASLLLKpsgqpyspperrksKKKEEPPPSDIPSPGRQGSSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 650 -EVLQEYIAGADTIMEDPatrdfVVMRARMMAAKLLGALCCYIcdpsvnmvnQEIKPADSLGQLLLFYLNSKSALQRISV 728
Cdd:pfam12054 81 hNVDKPMIGGDVTLVGMD-----VVIRTRIAAAKALGLLLSYW---------PEESPLDFFTKLLLPYLNSPSALQRLLA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 729 ALVICEWAALQK-----ECKAVTLAVQPRLLDIL---SEHLYYDEIAVPFTRMQNECKQFISSLADAHIEVGNRVNN--- 797
Cdd:pfam12054 147 AIIIEEWAKNCKkekssSVSTLPETLSEKLLEILenpSRPPYYRELVPYLTRLRTQCQQLLNTFRDVGKVSQSKLPKlav 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 798 ----------NVLTIDQANDLVTTIFNEVTSTFDLNPQVL--QQLDSKRHQVQMTVAETNQEWQVLQLRVHTFAACAVVS 865
Cdd:pfam12054 227 vvqgepeagpGAFSIEQAEKLVGEDYDKLKKSLSPKQKLLalQQLEDRRRRVQAAIEEAKEAKEQRDVRVLAAAAGALVA 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 866 LQQLPEKLNPIIKPLMETIKKEENTLVQNYAAQYIAKLLQQCTTR-TPCPNSKVIKNLCSSLCVDPYLTPCVtcpvptqs 944
Cdd:pfam12054 307 LKGLPKKLNPIIKPLMDSIKKEENEELQQRSADALAHLIDLCVDRgKPGPNDKIVKNLCTFLCVDTSETPEF-------- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 945 gqenskgsnsekdgmHHTVTKHRGIITLYRHQKAAFAITSrrgpipkaikaqiadlpagssgtilVELDEGQKPYLVQRR 1024
Cdd:pfam12054 379 ---------------HPNAKLTDGILTLRKEEDKADHADA-------------------------AKFEEEAKEARIQRR 418
|
490 500
....*....|....*....|....*.
gi 123858774 1025 GAEFALTTIVKHFGAEMAVKLPHLWD 1050
Cdd:pfam12054 419 GAKLALEQLAKKFGASLFEKVPKLWE 444
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
1261-1504 |
2.73e-83 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 272.52 E-value: 2.73e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1261 INAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhCQRAQEYarsklaecMPLPSLVVCPPTLTGHW 1340
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALL----LSRKEEG--------RKGPSLVVAPTSLIYNW 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1341 VDEVGKFCSReyLNPLHYTGPPTERiRLQHQVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVK 1420
Cdd:cd18012 69 EEEAAKFAPE--LKVLVIHGTKRKR-EKLRALEDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1421 QLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARsssreqeagvlAMDALHRQVLPFLL 1500
Cdd:cd18012 146 ALKADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDEE-----------ALEELKKLISPFIL 214
|
....
gi 123858774 1501 RRMK 1504
Cdd:cd18012 215 RRLK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
1258-1813 |
7.04e-82 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 293.63 E-value: 7.04e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1258 PVPINAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRAqeyarsklaecMPLPSLVVCPPTLT 1337
Cdd:PLN03142 163 PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRG-----------ITGPHMVVAPKSTL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1338 GHWVDEVGKFCSreYLNPLHYTGPPTERirlQHQvkRHNLIVA--------SYDVVRNDIDFFRNIKFNYCILDEGHVIK 1409
Cdd:PLN03142 232 GNWMNEIRRFCP--VLRAVKFHGNPEER---AHQ--REELLVAgkfdvcvtSFEMAIKEKTALKRFSWRYIIIDEAHRIK 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1410 NGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGkpilasrdarSSSREQEAGVLAMd 1489
Cdd:PLN03142 305 NENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQ----------ISGENDQQEVVQQ- 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1490 aLHRQVLPFLLRRMKEDVLQDLPPKIIQDYYCTLSPLQVQLYedfaKSRAKCDVDetvssaALSEETEKPKLkatghVFQ 1569
Cdd:PLN03142 374 -LHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYY----KALLQKDLD------VVNAGGERKRL-----LNI 437
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1570 ALQyLRKLCNHPALV--LTPQHPEFksTTEKLtVQNSSlhdiqhapklsalKQLLLDCGLGNGSSTESgtesvvaqhRIL 1647
Cdd:PLN03142 438 AMQ-LRKCCNHPYLFqgAEPGPPYT--TGEHL-VENSG-------------KMVLLDKLLPKLKERDS---------RVL 491
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1648 IFCQLKSMLDIVEHDLLkphLPSVTYLRLDGSIPPGQRHSIVSRFNNDPSID-VLLLTTHVGGLGLNLTGADTVVFVEHD 1726
Cdd:PLN03142 492 IFSQMTRLLDILEDYLM---YRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADIVILYDSD 568
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1727 WNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQKFKMNIANTVISQ----ENSSLqsmGTDQLLDLFTLDkd 1802
Cdd:PLN03142 569 WNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQgrlaEQKTV---NKDELLQMVRYG-- 643
|
570
....*....|.
gi 123858774 1803 gkAEKADSSTS 1813
Cdd:PLN03142 644 --AEMVFSSKD 652
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
1268-1584 |
2.78e-68 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 232.19 E-value: 2.78e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1268 YQQDGVNWLAFL-NKYKLHGILCDDMGLGKTLQSICILAGDHCQRAQeyarsklaecMPLPSLVVCPPTLTGHWVDEVGK 1346
Cdd:pfam00176 1 YQIEGVNWMLSLeNNLGRGGILADEMGLGKTLQTISLLLYLKHVDKN----------WGGPTLIVVPLSLLHNWMNEFER 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1347 FCSREYLNPLHYTGPPTERIRLQHQVKR---HNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLT 1423
Cdd:pfam00176 71 WVSPPALRVVVLHGNKRPQERWKNDPNFladFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1424 ANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSReqeagvlamdaLHRQVLPFLLRRM 1503
Cdd:pfam00176 151 TRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGVSR-----------LHKLLKPFLLRRT 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1504 KEDVLQDLPPKIIQDYYCTLSPLQVQLYEDFAKSRakcDVDETVSSaalseetEKPKLKATGhVFQALQYLRKLCNHPAL 1583
Cdd:pfam00176 220 KKDVEKSLPPKVEYILFCRLSKLQRKLYQTFLLKK---DLNAIKTG-------EGGREIKAS-LLNILMRLRKICNHPGL 288
|
.
gi 123858774 1584 V 1584
Cdd:pfam00176 289 I 289
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
1265-1454 |
6.26e-65 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 218.20 E-value: 6.26e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRAQeyarsklaecmPLPSLVVCPPTLTGHWVDEV 1344
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKE-----------RGPVLVVCPLSVLENWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSReyLNPLHYTGPPTERIRLQHQ--VKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQL 1422
Cdd:cd17919 70 EKWTPD--LRVVVYHGSQRERAQIRAKekLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKAL 147
|
170 180 190
....*....|....*....|....*....|..
gi 123858774 1423 TANYRIILSGTPIQNNVLELWSLFDFLMPGFL 1454
Cdd:cd17919 148 RAKRRLLLTGTPLQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
1265-1502 |
1.15e-59 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 205.30 E-value: 1.15e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHcqraqeyaRSKLAEcmplPSLVVCPPTLTGHWVDEV 1344
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMF--------DSGLIK----SVLVVMPTSLIPHWVKEF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSREYLNpLHYTGPPTERIRLQHQVKR-HNLIVASYDVVRNDIDFF-----RNIKFNYCILDEGHVIKNGKTKLSKA 1418
Cdd:cd18001 69 AKWTPGLRVK-VFHGTSKKERERNLERIQRgGGVLLTTYGMVLSNTEQLsaddhDEFKWDYVILDEGHKIKNSKTKSAKS 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1419 VKQLTANYRIILSGTPIQNNVLELWSLFDFLMPG-FLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLP 1497
Cdd:cd18001 148 LREIPAKNRIILTGTPIQNNLKELWALFDFACNGsLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQIIKP 227
|
....*
gi 123858774 1498 FLLRR 1502
Cdd:cd18001 228 YFLRR 232
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
1605-1754 |
2.73e-53 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 183.06 E-value: 2.73e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1605 SLHDIQHAPKLSALKQLLLDCGLGNgsstesgtesvvaqHRILIFCQLKSMLDIVEHDLLKPHlpsVTYLRLDGSIPPGQ 1684
Cdd:cd18793 3 PKIEEVVSGKLEALLELLEELREPG--------------EKVLIFSQFTDTLDILEEALRERG---IKYLRLDGSTSSKE 65
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1685 RHSIVSRFNNDPSIDVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLI 1754
Cdd:cd18793 66 RQKLVDRFNEDPDIRVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
1265-1504 |
1.92e-51 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 181.82 E-value: 1.92e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhCQRAQEyarsklaecMPLPSLVVCPPTLTGHWVDEV 1344
Cdd:cd18009 4 MRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLA---HLRERG---------VWGPFLVIAPLSTLPNWVNEF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSReyLNPLHYTGPPTERIRLQHQVKRHN-------LIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSK 1417
Cdd:cd18009 72 ARFTPS--VPVLLYHGTKEERERLRKKIMKREgtlqdfpVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1418 AVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASR--DARSSSREQEAGVLAMdaLHRQV 1495
Cdd:cd18009 150 ELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFDFSSLSDNaaDISNLSEEREQNIVHM--LHAIL 227
|
....*....
gi 123858774 1496 LPFLLRRMK 1504
Cdd:cd18009 228 KPFLLRRLK 236
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
1265-1502 |
1.81e-49 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 176.42 E-value: 1.81e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILA---------GDHCQRAQEYARSKLAECMPLPSLVVCPPT 1335
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAavlgktgtrRDRENNRPRFKKKPPASSAKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1336 LTGHWVDEVGKFcsrEYLNPLHYTGPPTERIrLQHQVK--RHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKT 1413
Cdd:cd18005 81 VLYNWKDELDTW---GHFEVGVYHGSRKDDE-LEGRLKagRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1414 KLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHR 1493
Cdd:cd18005 157 KLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAV 236
|
....*....
gi 123858774 1494 QVLPFLLRR 1502
Cdd:cd18005 237 KLSKFFLRR 245
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
1265-1454 |
8.30e-49 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 172.51 E-value: 8.30e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCqrAQEYARsklaecmplPSLVVCPPTLTGHWVDEV 1344
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHH--SKLGLG---------PSLIVCPATVLKQWVKEF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSREYLNPLHYTGPPT-----------ERIRLQHQVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKT 1413
Cdd:cd18000 70 HRWWPPFRVVVLHSSGSGTgseeklgsierKSQLIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDA 149
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 123858774 1414 KLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFL 1454
Cdd:cd18000 150 EITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFPPYL 190
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
1265-1502 |
9.12e-49 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 174.40 E-value: 9.12e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWL----AFLNKYKLHG-ILCDDMGLGKTLQSICILAGDHCQRaqEYARSKLAECmplpsLVVCPPTLTGH 1339
Cdd:cd18004 1 LRPHQREGVQFLydclTGRRGYGGGGaILADEMGLGKTLQAIALVWTLLKQG--PYGKPTAKKA-----LIVCPSSLVGN 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1340 WVDEVGKFCSREYLNPLHYTGPPTERIRLQHQV---KRHNLIVASYDVVRNDID-FFRNIKFNYCILDEGHVIKNGKTKL 1415
Cdd:cd18004 74 WKAEFDKWLGLRRIKVVTADGNAKDVKASLDFFssaSTYPVLIISYETLRRHAEkLSKKISIDLLICDEGHRLKNSESKT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1416 SKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQV 1495
Cdd:cd18004 154 TKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELT 233
|
....*..
gi 123858774 1496 LPFLLRR 1502
Cdd:cd18004 234 SRFILRR 240
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
1265-1502 |
2.85e-47 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 170.16 E-value: 2.85e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLaflnkykLH--GILCDDMGLGKTLQSICILAGDHCQRAQEY----ARSKLAECMPLPS--LVVCPPTL 1336
Cdd:cd18008 1 LLPYQKQGLAWM-------LPrgGILADEMGLGKTIQALALILATRPQDPKIPeeleENSSDPKKLYLSKttLIVVPLSL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1337 TGHWVDEVGKFCSREYLNPLHYTGPptERIRLQHQVKRHNLIVASYDVVRNDIDFF----------------RNIKFNYC 1400
Cdd:cd18008 74 LSQWKDEIEKHTKPGSLKVYVYHGS--KRIKSIEELSDYDIVITTYGTLASEFPKNkkgggrdskekeasplHRIRWYRV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1401 ILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDArsssre 1480
Cdd:cd18008 152 ILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKNDRK------ 225
|
250 260
....*....|....*....|..
gi 123858774 1481 qeagvlAMDALHRQVLPFLLRR 1502
Cdd:cd18008 226 ------ALERLQALLKPILLRR 241
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
1265-1502 |
8.75e-45 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 162.14 E-value: 8.75e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRaQEYArsklaecmplPSLVVCPPTLTGHWVDEV 1344
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEK-GNWG----------PHLIVVPTSVMLNWEMEF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSReyLNPLHYTGPPTERIRlqhqvKRH--------NLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLS 1416
Cdd:cd18003 70 KRWCPG--FKILTYYGSAKERKL-----KRQgwmkpnsfHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRW 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1417 KAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPIlasrDARSSSREQEAGVLaMDALHRQVL 1496
Cdd:cd18003 143 QTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPL----TAMSEGSQEENEEL-VRRLHKVLR 217
|
....*.
gi 123858774 1497 PFLLRR 1502
Cdd:cd18003 218 PFLLRR 223
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
1265-1451 |
9.26e-45 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 160.63 E-value: 9.26e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqRAQEYARsklaecmPLPSLVVCPPTLTGHWVDEV 1344
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLA-----YLKEIGI-------PGPHLVVVPSSTLDNWLREF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSReyLNPLHYTGPPTERIRLQHQVKR----HNLIVASYDVV---RNDIDFFRNIKFNYCILDEGHVIKNGKTKLSK 1417
Cdd:cd17998 69 KRWCPS--LKVEPYYGSQEERKHLRYDILKgledFDVIVTTYNLAtsnPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYR 146
|
170 180 190
....*....|....*....|....*....|....
gi 123858774 1418 AVKQLTANYRIILSGTPIQNNVLELWSLFDFLMP 1451
Cdd:cd17998 147 HLMTINANFRLLLTGTPLQNNLLELMSLLNFIMP 180
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
1262-1504 |
7.95e-41 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 150.55 E-value: 7.95e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1262 NAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqraqeYArsKLAECMPLPSLVVCPPTLTGHWV 1341
Cdd:cd17997 1 GGTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLG---------YL--KHYKNINGPHLIIVPKSTLDNWM 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1342 DEVGKFCSReyLNPLHYTGPPTER---IRLQHQVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKA 1418
Cdd:cd17997 70 REFKRWCPS--LRVVVLIGDKEERadiIRDVLLPGKFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1419 VKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYgkpilaSRDARSSSREQeagvlAMDALHRQVLPF 1498
Cdd:cd17997 148 VRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWF------NVNNCDDDNQE-----VVQRLHKVLRPF 216
|
....*.
gi 123858774 1499 LLRRMK 1504
Cdd:cd17997 217 LLRRIK 222
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
1265-1502 |
8.28e-41 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 151.12 E-value: 8.28e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqraqeyarsKLAECMPL--PSLVVCPPTLTGHWVD 1342
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLA-------------HLAEEHNIwgPFLVIAPASTLHNWQQ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1343 EVGKFCSReyLNPLHYTGPPTERIRLQHQVKRHNL---------IVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKT 1413
Cdd:cd18002 68 EISRFVPQ--FKVLPYWGNPKDRKVLRKFWDRKNLytrdapfhvVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1414 KLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEagvlaMDALHR 1493
Cdd:cd18002 146 SRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGLNEHQ-----LKRLHM 220
|
....*....
gi 123858774 1494 QVLPFLLRR 1502
Cdd:cd18002 221 ILKPFMLRR 229
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
1265-1502 |
1.04e-40 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 150.48 E-value: 1.04e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFlNKYKLHG-ILCDDMGLGKTLQSICILagdhcqraqEYARSKlaECMPLPSLVVCPPTLTGHWVDE 1343
Cdd:cd17995 1 LRDYQLEGVNWLLF-NWYNRRNcILADEMGLGKTIQSIAFL---------EHLYQV--EGIRGPFLVIAPLSTIPNWQRE 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1344 VGKFCSreyLNPLHYTGPPTER-IRLQHQ-------------VKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIK 1409
Cdd:cd17995 69 FETWTD---MNVVVYHGSGESRqIIQQYEmyfkdaqgrkkkgVYKFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1410 NGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGkpilasrDARSSSREQEagvlamd 1489
Cdd:cd17995 146 NRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFG-------DLKTAEQVEK------- 211
|
250
....*....|...
gi 123858774 1490 aLHRQVLPFLLRR 1502
Cdd:cd17995 212 -LQALLKPYMLRR 223
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
1262-1504 |
1.14e-40 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 150.60 E-value: 1.14e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1262 NAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqraqeYarskLAECMPL--PSLVVCP-PTLTG 1338
Cdd:cd17996 1 GGTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLIT---------Y----LMEKKKNngPYLVIVPlSTLSN 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1339 hWVDEVGKFCSReyLNPLHYTGPPTERIRLQHQVK--RHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLS 1416
Cdd:cd17996 68 -WVSEFEKWAPS--VSKIVYKGTPDVRKKLQSQIRagKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLT 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1417 KAVKQ-LTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQV 1495
Cdd:cd17996 145 QTLNTyYHARYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTGEQVKIELNEEETLLIIRRLHKVL 224
|
....*....
gi 123858774 1496 LPFLLRRMK 1504
Cdd:cd17996 225 RPFLLRRLK 233
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
1265-1502 |
1.18e-40 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 149.90 E-value: 1.18e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqraqeYARSKLAecMPLPSLVVCPPTLTGHWVDEV 1344
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLW---------YLAGRLK--LLGPFLVLCPLSVLDNWKEEL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSReyLNPLHYTGPPTERIRLQHQVK---RHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQ 1421
Cdd:cd18006 70 NRFAPD--LSVITYMGDKEKRLDLQQDIKstnRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1422 LTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTER--QFAARYgkpilasrdarsssREQEAGVLAMDALHRQVLPFL 1499
Cdd:cd18006 148 FSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFPKDKldDFIKAY--------------SETDDESETVEELHLLLQPFL 213
|
...
gi 123858774 1500 LRR 1502
Cdd:cd18006 214 LRR 216
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
1264-1502 |
4.11e-40 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 148.66 E-value: 4.11e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1264 ELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdHCQRAQEyarsklaecMPLPSLVVCPPTLTGHWVDE 1343
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLS--YLFHSQQ---------QYGPFLVVVPLSTMPAWQRE 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1344 VGKFCSReyLNPLHYTGPPTER--IR----LQHQVKR--HNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKL 1415
Cdd:cd17993 70 FAKWAPD--MNVIVYLGDIKSRdtIReyefYFSQTKKlkFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1416 SKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKpilasrdarsssrEQEAGVlamDALHRQV 1495
Cdd:cd17993 148 YEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEHDE-------------EQEKGI---ADLHKEL 211
|
....*..
gi 123858774 1496 LPFLLRR 1502
Cdd:cd17993 212 EPFILRR 218
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
1263-1514 |
1.26e-35 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 136.72 E-value: 1.26e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1263 AELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqrAQEYARSklaecMPLPSLVVCPPTLTGHWVD 1342
Cdd:cd18064 14 GKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLG------YMKHYRN-----IPGPHMVLVPKSTLHNWMA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1343 EVGKFCSReyLNPLHYTGPPTERIRLQHQV---KRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAV 1419
Cdd:cd18064 83 EFKRWVPT--LRAVCLIGDKDQRAAFVRDVllpGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1420 KQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYgkpilasrDARSSSREQEagvlAMDALHRQVLPFL 1499
Cdd:cd18064 161 REFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWF--------DTNNCLGDQK----LVERLHMVLRPFL 228
|
250
....*....|....*
gi 123858774 1500 LRRMKEDVLQDLPPK 1514
Cdd:cd18064 229 LRRIKADVEKSLPPK 243
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
1265-1502 |
5.09e-33 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 129.13 E-value: 5.09e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWL----AFLNKYKLHG-ILCDDMGLGKTLQSICIL-----AGDHCQRAQEYArsklaecmplpsLVVCPP 1334
Cdd:cd18067 1 LRPHQREGVKFLyrcvTGRRIRGSHGcIMADEMGLGKTLQCITLMwtllrQSPQCKPEIDKA------------IVVSPS 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1335 TLTGHWVDEVGKFCSREyLNPLHYTGPPTERIRLQ---------HQVKRHNLIVaSYDVVRNDIDFFRNIKFNYCILDEG 1405
Cdd:cd18067 69 SLVKNWANELGKWLGGR-LQPLAIDGGSKKEIDRKlvqwasqqgRRVSTPVLII-SYETFRLHVEVLQKGEVGLVICDEG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1406 HVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGV 1485
Cdd:cd18067 147 HRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGE 226
|
250
....*....|....*..
gi 123858774 1486 LAMDALHRQVLPFLLRR 1502
Cdd:cd18067 227 EKLQELISIVNRCIIRR 243
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
1261-1504 |
7.73e-33 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 128.64 E-value: 7.73e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1261 INAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqRAQEYARsklaecMPLPSLVVCPPTLTGHW 1340
Cdd:cd18063 20 INGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALIT-----YLMEHKR------LNGPYLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1341 VDEVGKFCSReyLNPLHYTGPPTERIRLQHQVK--RHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKA 1418
Cdd:cd18063 89 TYEFDKWAPS--VVKISYKGTPAMRRSLVPQLRsgKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1419 VK-QLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPiLASRDARSSSREQEAgVLAMDALHRQVLP 1497
Cdd:cd18063 167 LNtHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAP-FAMTGERVDLNEEET-ILIIRRLHKVLRP 244
|
....*..
gi 123858774 1498 FLLRRMK 1504
Cdd:cd18063 245 FLLRRLK 251
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
1287-1482 |
2.86e-32 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 126.64 E-value: 2.86e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1287 ILCDDMGLGKTLQSICILagdhcqraQEYARSKLAECMPLpslVVCPPTLTGHWVDEVGKFCSREYLNPLHYTGPPTERI 1366
Cdd:cd18007 30 ILAHTMGLGKTLQVITFL--------HTYLAAAPRRSRPL---VLCPASTLYNWEDEFKKWLPPDLRPLLVLVSLSASKR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1367 RLQHQV------KRHNLIVASYDVVRNDI-----------DFFRNIKFNYC---ILDEGHVIKNGKTKLSKAVKQLTANY 1426
Cdd:cd18007 99 ADARLRkinkwhKEGGVLLIGYELFRNLAsnattdprlkqEFIAALLDPGPdllVLDEGHRLKNEKSQLSKALSKVKTKR 178
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 123858774 1427 RIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQE 1482
Cdd:cd18007 179 RILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQCVDSTEEDVR 234
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
1265-1449 |
5.75e-32 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 126.06 E-value: 5.75e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHG-ILCDDMGLGKTLQSIC-ILAGDHCQRAQEYAR--------SKLAECMpLPS---LVV 1331
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGgILADDMGLGKTLTMIAlILAQKNTQNRKEEEKekalteweSKKDSTL-VPSagtLVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1332 CPPTLTGHWVDEVGKFCSREYLNPLHYTGPptERIRLQHQVKRHNLIVASYDVVRNDIDFFRN---------IKFNYCIL 1402
Cdd:cd18072 80 CPASLVHQWKNEVESRVASNKLRVCLYHGP--NRERIGEVLRDYDIVITTYSLVAKEIPTYKEesrssplfrIAWARIIL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 123858774 1403 DEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFL 1449
Cdd:cd18072 158 DEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFL 204
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
1265-1502 |
1.24e-31 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 124.57 E-value: 1.24e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLH-----GILCDDMGLGKTLQSICILAGDHCQraQEYARSKLAEcmplPSLVVCPPTLTGH 1339
Cdd:cd18066 1 LRPHQREGIEFLYECVMGMRVnerfgAILADEMGLGKTLQCISLIWTLLRQ--GPYGGKPVIK----RALIVTPGSLVKN 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1340 WVDEVGKFCSREylnplhytgppteRIRL-----QHQVKR------HNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVI 1408
Cdd:cd18066 75 WKKEFQKWLGSE-------------RIKVftvdqDHKVEEfiasplYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1409 KNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAM 1488
Cdd:cd18066 142 KNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARA 221
|
250
....*....|....
gi 123858774 1489 DALHRQVLPFLLRR 1502
Cdd:cd18066 222 AELTRLTGLFILRR 235
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
1261-1504 |
1.29e-31 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 125.16 E-value: 1.29e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1261 INAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqRAQEYARsklaecMPLPSLVVCPPTLTGHW 1340
Cdd:cd18062 20 VNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALIT-----YLMEHKR------INGPFLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1341 VDEVGKFCSReyLNPLHYTGPPTERIRLQHQVK--RHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKA 1418
Cdd:cd18062 89 VYEFDKWAPS--VVKVSYKGSPAARRAFVPQLRsgKFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1419 VK-QLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASrdARSSSREQEAGVLAMDALHRQVLP 1497
Cdd:cd18062 167 LNtHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMT--GEKVDLNEEETILIIRRLHKVLRP 244
|
....*..
gi 123858774 1498 FLLRRMK 1504
Cdd:cd18062 245 FLLRRLK 251
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
1265-1504 |
3.68e-31 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 123.20 E-value: 3.68e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqraqeyaRSKLAECMPLPSLVVCPPTLTGHWVDEV 1344
Cdd:cd18065 16 LRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLG-----------YLKHYRNIPGPHMVLVPKSTLHNWMNEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSReyLNPLHYTGPPTER---IRLQHQVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQ 1421
Cdd:cd18065 85 KRWVPS--LRAVCLIGDKDARaafIRDVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVRE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1422 LTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYgkpilasrDARSSSREQEagvlAMDALHRQVLPFLLR 1501
Cdd:cd18065 163 FKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWF--------DTKNCLGDQK----LVERLHAVLKPFLLR 230
|
...
gi 123858774 1502 RMK 1504
Cdd:cd18065 231 RIK 233
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
1265-1482 |
4.40e-31 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 122.31 E-value: 4.40e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWlAFLNKYKLhgILCDDMGLGKTLQSICILAgdhcqraqeYARsklAECmplPSLVVCPPTLTGHWVDEV 1344
Cdd:cd18010 1 LLPFQREGVCF-ALRRGGRV--LIADEMGLGKTVQAIAIAA---------YYR---EEW---PLLIVCPSSLRLTWADEI 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSREYLNPLHYTGPPTERIR-LQHQVkrhnLIVaSYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLT 1423
Cdd:cd18010 63 ERWLPSLPPDDIQVIVKSKDGLRdGDAKV----VIV-SYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLL 137
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 123858774 1424 --ANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASR--DARSSSREQE 1482
Cdd:cd18010 138 krAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRRYCAAKQGGFgwDYSGSSNLEE 200
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
1262-1502 |
2.76e-30 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 120.88 E-value: 2.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1262 NAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRaQEYArsklaecmplPSLVVCPPTLTGHWV 1341
Cdd:cd18054 18 NLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQH-QLYG----------PFLLVVPLSTLTSWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1342 DE-------------VGKFCSREYLNPLHYTGPPTERIRLqhqvkrhNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVI 1408
Cdd:cd18054 87 REfeiwapeinvvvyIGDLMSRNTIREYEWIHSQTKRLKF-------NALITTYEILLKDKTVLGSINWAFLGVDEAHRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1409 KNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKpilasrdarssSREQeagvlAM 1488
Cdd:cd18054 160 KNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGK-----------GREN-----GY 223
|
250
....*....|....
gi 123858774 1489 DALHRQVLPFLLRR 1502
Cdd:cd18054 224 QSLHKVLEPFLLRR 237
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
1286-1502 |
1.29e-29 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 119.11 E-value: 1.29e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1286 GILCDDMGLGKTLQSICILAGDhcqraqeyarsklaecmplPSLVVCPPTLTGHWVDEVGKFCSREYLNPLHYTGPptER 1365
Cdd:cd18071 51 GILADDMGLGKTLTTISLILAN-------------------FTLIVCPLSVLSNWETQFEEHVKPGQLKVYTYHGG--ER 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1366 IRLQHQVKRHNLIVASYDVVRNDIDF-----FRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVL 1440
Cdd:cd18071 110 NRDPKLLSKYDIVLTTYNTLASDFGAkgdspLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPK 189
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 123858774 1441 ELWSLFDFLMPGFLGTERQFAARYGKPIlasrdarssSREQEAGVLAMDALHRQVlpfLLRR 1502
Cdd:cd18071 190 DLGSLLSFLHLKPFSNPEYWRRLIQRPL---------TMGDPTGLKRLQVLMKQI---TLRR 239
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
1264-1502 |
1.92e-27 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 112.84 E-value: 1.92e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1264 ELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILaGDHCQRAQEYArsklaecmplPSLVVCPPTLTGHWVDE 1343
Cdd:cd18053 20 ELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFL-NYLFHEHQLYG----------PFLLVVPLSTLTSWQRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1344 V-------------GKFCSREYLNPLHYTGPPTERIRLqhqvkrhNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKN 1410
Cdd:cd18053 89 IqtwapqmnavvylGDINSRNMIRTHEWMHPQTKRLKF-------NILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1411 GKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKpilaSRDARSSSreqeagvlamda 1490
Cdd:cd18053 162 DDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGK----GREYGYAS------------ 225
|
250
....*....|..
gi 123858774 1491 LHRQVLPFLLRR 1502
Cdd:cd18053 226 LHKELEPFLLRR 237
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
1265-1451 |
3.74e-25 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 106.66 E-value: 3.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNkyklhGILCDDMGLGKTLQSI-CILAGDHCQRAQE--YARSKLAECMPLP-----------SLV 1330
Cdd:cd18070 1 LLPYQRRAVNWMLVPG-----GILADEMGLGKTVEVLaLILLHPRPDNDLDaaDDDSDEMVCCPDClvaetpvsskaTLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1331 VCPPTLTGHWVDEVGKFcSREYLNPLHYTGPPTE---RIRLQHQVKRHNLIVASYDVVRNDIDF---FRN---------- 1394
Cdd:cd18070 76 VCPSAILAQWLDEINRH-VPSSLKVLTYQGVKKDgalASPAPEILAEYDIVVTTYDVLRTELHYaeaNRSnrrrrrqkry 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 123858774 1395 ---------IKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMP 1451
Cdd:cd18070 155 eappsplvlVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGV 220
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
1286-1480 |
7.71e-25 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 105.36 E-value: 7.71e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1286 GILCDDMGLGKTLQSICILagdH----CQRAQEYARSklaecmplpsLVVCPPTLTGHWVDEVGKFcsREYLNPLH---- 1357
Cdd:cd18068 31 CILAHCMGLGKTLQVVTFL---HtvllCEKLENFSRV----------LVVCPLNTVLNWLNEFEKW--QEGLKDEEkiev 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1358 -----YTGPPTERIRLQHQVKRHNLIVASYDVVRNdIDFFRNIKF-----------------NYCILDEGHVIKNGKTKL 1415
Cdd:cd18068 96 nelatYKRPQERSYKLQRWQEEGGVMIIGYDMYRI-LAQERNVKSreklkeifnkalvdpgpDFVVCDEGHILKNEASAV 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 123858774 1416 SKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSRE 1480
Cdd:cd18068 175 SKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQCADSTLVD 239
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
1265-1502 |
1.78e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 103.59 E-value: 1.78e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhcqraQEYARSKLAEcmplPSLVVCPPTLTGHWVDEV 1344
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFL--------QEVYNVGIHG----PFLVIAPLSTITNWEREF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSreyLNPLHYTGPPTERIRLQHQ--------------VKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKN 1410
Cdd:cd18060 69 NTWTE---MNTIVYHGSLASRQMIQQYemyckdsrgrlipgAYKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKN 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1411 GKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYGkpilasrDARSSSREQEagvlamda 1490
Cdd:cd18060 146 RNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFG-------DLKTEEQVQK-------- 210
|
250
....*....|..
gi 123858774 1491 LHRQVLPFLLRR 1502
Cdd:cd18060 211 LQAILKPMMLRR 222
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
1264-1458 |
1.02e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 100.64 E-value: 1.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1264 ELRKYQQDGVNWLAFLNKyklHGILCDDMGLGKTLQsicilagdhcqrAQEYARSKLAECMPLPSLVVCP-PTLTGHWVD 1342
Cdd:smart00487 8 PLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLA------------ALLPALEALKRGKGGRVLVLVPtRELAEQWAE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1343 EVGKFCSREYLNPLHYTGPPTERIRLQHQVKRH-NLIVASYDVVRNDI--DFFRNIKFNYCILDEGHVIKNG--KTKLSK 1417
Cdd:smart00487 73 ELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLenDKLSLSNVDLVILDEAHRLLDGgfGDQLEK 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 123858774 1418 AVKQL-TANYRIILSGTP---IQNNVLELWSLFDFLMPGFLGTER 1458
Cdd:smart00487 153 LLKLLpKNVQLLLLSATPpeeIENLLELFLNDPVFIDVGFTPLEP 197
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
1265-1465 |
5.81e-23 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 99.34 E-value: 5.81e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFlNKYKLHG-ILCDDMGLGKTLQSICILAGDHCQRAQEyarsklaecmplPSLVVCPPTLTGHWVDE 1343
Cdd:cd18059 1 LREYQLEGVNWLLF-NWYNTRNcILADEMGLGKTIQSITFLYEIYLKGIHG------------PFLVIAPLSTIPNWERE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1344 vgkFCSREYLNPLHYTGPPTERIRLQ--------------HQVKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIK 1409
Cdd:cd18059 68 ---FRTWTELNVVVYHGSQASRRTIQlyemyfkdpqgrviKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLK 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 123858774 1410 NGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYG 1465
Cdd:cd18059 145 NRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFG 200
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
1265-1465 |
4.87e-22 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 96.65 E-value: 4.87e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAgdhcqraQEYARSklaecMPLPSLVVCPPTLTGHWVDEv 1344
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLS-------EIFLMG-----IRGPFLIIAPLSTITNWERE- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 gkFCSREYLNPLHYTGPPTERIRLQHQ--------------VKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKN 1410
Cdd:cd18058 68 --FRTWTEMNAIVYHGSQISRQMIQQYemyyrdeqgnplsgIFKFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKN 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 123858774 1411 GKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYG 1465
Cdd:cd18058 146 RNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFG 200
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
1644-1743 |
2.13e-21 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 90.73 E-value: 2.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1644 HRILIFCQLKSMLDIvehDLLKpHLPSVTYLRLDGSIPPGQRHSIVSRFNNDpSIDVLLlTTHVGGLGLNLTGADTVVFV 1723
Cdd:pfam00271 16 GKVLIFSQTKKTLEA---ELLL-EKEGIKVARLHGDLSQEEREEILEDFRKG-KIDVLV-ATDVAERGLDLPDVDLVINY 89
|
90 100
....*....|....*....|
gi 123858774 1724 EHDWNPMRDLQAMDRAHRIG 1743
Cdd:pfam00271 90 DLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
1287-1469 |
9.14e-21 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 92.96 E-value: 9.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1287 ILCDDMGLGKTLQSICILagdhcqraqeyarSKLAECMPLPS-LVVCPPTLTGHWVDEVGKFCSREYLNPLhyTGPPTER 1365
Cdd:cd18069 32 ILAHSMGLGKTLQVISFL-------------DVLLRHTGAKTvLAIVPVNTLQNWLSEFNKWLPPPEALPN--VRPRPFK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1366 IRLQHQVkrHNLIVASYDVVRN----------DIDFFRNIKF-NYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTP 1434
Cdd:cd18069 97 VFILNDE--HKTTAARAKVIEDwvkdggvllmGYEMFRLRPGpDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYP 174
|
170 180 190
....*....|....*....|....*....|....*
gi 123858774 1435 IQNNVLELWSLFDFLMPGFLGTERQFAARYGKPIL 1469
Cdd:cd18069 175 LQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPIL 209
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
1265-1465 |
2.72e-20 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 91.61 E-value: 2.72e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhcqraQEYARSKLAEcmplPSLVVCPPTLTGHWVDEv 1344
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFL--------YEILLTGIRG----PFLIIAPLSTIANWERE- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 gkFCSREYLNPLHYTGPPTERIRLQHQ--------------VKRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKN 1410
Cdd:cd18061 68 --FRTWTDLNVVVYHGSLISRQMIQQYemyfrdsqgriirgAYRFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKN 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 123858774 1411 GKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYG 1465
Cdd:cd18061 146 KNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFG 200
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
1265-1502 |
3.06e-20 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 90.58 E-value: 3.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhcqraqeYARSKLAECMPlPSLVVCPPTLTGHWVDEV 1344
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFL----------YSLYKEGHSKG-PFLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSREYLnpLHYTGppterirlqhqvkrHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTA 1424
Cdd:cd17994 70 EMWAPDFYV--VTYVG--------------DHVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKI 133
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 123858774 1425 NYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYgkpilasrdARSSSREQeagvlaMDALHRQVLPFLLRR 1502
Cdd:cd17994 134 GYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEF---------ADISKEDQ------IKKLHDLLGPHMLRR 196
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
1265-1502 |
2.40e-18 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 86.22 E-value: 2.40e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhcqraqeYARSKLAECMPlPSLVVCPPTLTGHWVDEV 1344
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFL----------YSLYKEGHTKG-PFLVSAPLSTIINWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKFCSREYLnpLHYTGPPTER-----------------------IRLQHQVKRHnLIVASYDVVRNDIDFFRNIKFNYCI 1401
Cdd:cd18055 70 QMWAPDFYV--VTYTGDKDSRaiirenefsfddnavkggkkafkMKREAQVKFH-VLLTSYELVTIDQAALGSIRWACLV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1402 LDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYgkpilasrdARSSSREQ 1481
Cdd:cd18055 147 VDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF---------ADISKEDQ 217
|
250 260
....*....|....*....|.
gi 123858774 1482 eagvlaMDALHRQVLPFLLRR 1502
Cdd:cd18055 218 ------IKKLHDLLGPHMLRR 232
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
1265-1502 |
9.07e-18 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 84.35 E-value: 9.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdhcqraqeYARSKLAECMPlPSLVVCPPTLTGHWVDE- 1343
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFL----------YSLYKEGHSKG-PYLVSAPLSTIINWEREf 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1344 ------------VGKFCSREYLNPLHY--------TGPPTERIRLQHQVKRHnLIVASYDVVRNDIDFFRNIKFNYCILD 1403
Cdd:cd18057 70 emwapdfyvvtyTGDKESRSVIRENEFsfednairSGKKVFRMKKEAQIKFH-VLLTSYELITIDQAILGSIEWACLVVD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1404 EGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMPGFLGTERQFAARYgkpilasrdARSSSREQea 1483
Cdd:cd18057 149 EAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF---------ADISKEDQ-- 217
|
250
....*....|....*....
gi 123858774 1484 gvlaMDALHRQVLPFLLRR 1502
Cdd:cd18057 218 ----IKKLHDLLGPHMLRR 232
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1657-1743 |
1.23e-17 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 79.18 E-value: 1.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1657 DIVEHDLLKPHLPsvtYLRLDGSIPPGQRHSIVSRFNNDPSidVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAM 1736
Cdd:smart00490 1 EELAELLKELGIK---VARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRI 75
|
....*..
gi 123858774 1737 DRAHRIG 1743
Cdd:smart00490 76 GRAGRAG 82
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
1265-1451 |
1.85e-17 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 83.58 E-value: 1.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILagdHCQRAQEYARSKLAECMPLPSLV-------VCPPTLt 1337
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFL---YSLYKEGHSKGPFLVSAPLSTIInwerefeMWAPDM- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1338 gHWVDEVGKFCSREYLNPLHYT--------GPPTERIRLQHQVKRHnLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIK 1409
Cdd:cd18056 77 -YVVTYVGDKDSRAIIRENEFSfednairgGKKASRMKKEASVKFH-VLLTSYELITIDMAILGSIDWACLIVDEAHRLK 154
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 123858774 1410 NGKTKLSKAVKQLTANYRIILSGTPIQNNVLELWSLFDFLMP 1451
Cdd:cd18056 155 NNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTP 196
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
1265-1453 |
4.05e-15 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 76.17 E-value: 4.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVnwLAFLNKYKLHGILCDDMGLGKTLQSICIlagdhcqrAQEYARSKLAEcmplPSLVVCPPTLTGHWVDEV 1344
Cdd:cd18011 1 PLPHQIDAV--LRALRKPPVRLLLADEVGLGKTIEAGLI--------IKELLLRGDAK----RVLILCPASLVEQWQDEL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1345 GKfcsREYLNPLHYTGPPTERIRLQHQV--KRHNLIVASYDVVRNDI---DFFRNIKFNYCILDEGHVIKNG----KTKL 1415
Cdd:cd18011 67 QD---KFGLPFLILDRETAAQLRRLIGNpfEEFPIVIVSLDLLKRSEerrGLLLSEEWDLVVVDEAHKLRNSgggkETKR 143
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 123858774 1416 SKAVKQLTAN--YRIILSGTPIQNNVLELWSLFDFLMPGF 1453
Cdd:cd18011 144 YKLGRLLAKRarHVLLLTATPHNGKEEDFRALLSLLDPGR 183
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
1265-1434 |
1.17e-08 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 55.77 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGV-NWLAFLNKYklHGILCDDMGLGKTLQSICILAgdhcqraqeyarsklaECMPLPSLVVCPPT-LTGHWVD 1342
Cdd:cd17926 1 LRPYQEEALeAWLAHKNNR--RGILVLPTGSGKTLTALALIA----------------YLKELRTLIVVPTDaLLDQWKE 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1343 EVGKFCSREYLNPLhyTGPPTERIRLQhqvkrhNLIVASYDVVRNDI----DFFRniKFNYCILDEGHVIkNGKTkLSKA 1418
Cdd:cd17926 63 RFEDFLGDSSIGLI--GGGKKKDFDDA------NVVVATYQSLSNLAeeekDLFD--QFGLLIVDEAHHL-PAKT-FSEI 130
|
170
....*....|....*.
gi 123858774 1419 VKQLTANYRIILSGTP 1434
Cdd:cd17926 131 LKELNAKYRLGLTATP 146
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
1265-1468 |
2.24e-08 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 56.59 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1265 LRKYQQDGVNwlaFLNKYKLHGILCDdMGLGKTLQSICILAGDHcqraqeyarsklAECMPLPSLVVCPPTLTGH-WVDE 1343
Cdd:cd18013 1 PHPYQKVAIN---FIIEHPYCGLFLD-MGLGKTVTTLTALSDLQ------------LDDFTRRVLVIAPLRVARStWPDE 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1344 VGKFcsrEYLNPLHY---TGPPTERIRLQHqvKRHNLIVASYDVVrNDIDFFRNIKFNY--CILDEGHVIKNGKTKLSKA 1418
Cdd:cd18013 65 VEKW---NHLRNLTVsvaVGTERQRSKAAN--TPADLYVINRENL-KWLVNKSGDPWPFdmVVIDELSSFKSPRSKRFKA 138
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 123858774 1419 VKQL--TANYRIILSGTPIQNNVLELWSLFDFLMPGflgtER------QFAARYGKPI 1468
Cdd:cd18013 139 LRKVrpVIKRLIGLTGTPSPNGLMDLWAQIALLDQG----ERlgrsitAYRERWFDPD 192
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
1608-1837 |
6.31e-08 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 57.82 E-value: 6.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1608 DIQHaPKLSALKQLLLDCGLGNGSStesgtesvvaqhRILIFCQLKSMLD-IVEHdLLKPHLPSVTYLrldgsippGQ-- 1684
Cdd:COG1111 331 DIEH-PKLSKLREILKEQLGTNPDS------------RIIVFTQYRDTAEmIVEF-LSEPGIKAGRFV--------GQas 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1685 -----------RHSIVSRFNNDpSIDVLLlTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVnVyrL 1753
Cdd:COG1111 389 kegdkgltqkeQIEILERFRAG-EFNVLV-ATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKREGRVV-V--L 463
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1754 ITRGTLEEKI--MGLQKFK------MNIANTVISQENSSLQSMGTDQLLDLFT---LDKDGKAEKADSSTSGKASMKSV- 1821
Cdd:COG1111 464 IAKGTRDEAYywSSRRKEKkmksilKKLKKLLDKQEKEKLKESAQATLDEFESikeLAEDEINEKDLDEIESSENGAHVd 543
|
250
....*....|....*....
gi 123858774 1822 ---LENLSDLWDAEQYDSE 1837
Cdd:COG1111 544 wrePVLLQVIVSTLAESLE 562
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
1264-1434 |
1.22e-05 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 50.02 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1264 ELRKYQQDGVN-WLAFLNKYKLHGILCDDMGLGKTLqsicILAGDhcqrAQEYARSKLAecmplpsLVVCP-PTLTGHWV 1341
Cdd:COG1061 80 ELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTV----LALAL----AAELLRGKRV-------LVLVPrRELLEQWA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 1342 DEVgkfcsREYLNPLHYTGPPTERirlqhqvkRHNLIVASYDVVRND--IDFFRNiKFNYCILDEGHVIknGKTKLSKAV 1419
Cdd:COG1061 145 EEL-----RRFLGDPLAGGGKKDS--------DAPITVATYQSLARRahLDELGD-RFGLVIIDEAHHA--GAPSYRRIL 208
|
170
....*....|....*
gi 123858774 1420 KQLTANYRIILSGTP 1434
Cdd:COG1061 209 EAFPAAYRLGLTATP 223
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
339-453 |
7.33e-05 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 44.62 E-value: 7.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 339 EDLVIRLLCVFALDRFGDfvsDEVVAP-----------VRETCAQTLGvvlkhmnETGVHKTVDVLLKLLTQEQWEVRHG 407
Cdd:COG1413 28 EDPDVRAAAARALGRLGD---PRAVPAllealkdpdpeVRAAAAEALG-------RIGDPEAVPALIAALKDEDPEVRRA 97
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 123858774 408 GLlgikYALAVRQDvintllPKVLTRIIEGLQDLDDDVRAVAAASL 453
Cdd:COG1413 98 AA----EALGRLGD------PAAVPALLEALKDPDWEVRRAAARAL 133
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
343-453 |
9.12e-04 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 41.15 E-value: 9.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123858774 343 IRLLCVFALDRFGDfvsDEVVAP-----------VRETCAQTLGvvlkhmnETGVHKTVDVLLKLLTQEQWEVRHGGLlg 411
Cdd:COG1413 1 VRRAAARALGRLGD---PAAVPAliaaladedpdVRAAAARALG-------RLGDPRAVPALLEALKDPDPEVRAAAA-- 68
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 123858774 412 ikYALAVRQDvintllPKVLTRIIEGLQDLDDDVRAVAAASL 453
Cdd:COG1413 69 --EALGRIGD------PEAVPALIAALKDEDPEVRRAAAEAL 102
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
1701-1745 |
3.19e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 38.07 E-value: 3.19e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 123858774 1701 LLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQK 1745
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD 69
|
|
| |
