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Conserved domains on  [gi|162287421|ref|NP_001034320|]
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kruppel-related zinc finger protein-like [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 28-68 6.90e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 6.90e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 162287421   28 VTYEDVHVNFTREEWALLDPSQKSLYKDVMLETYRTLRAIG 68
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-439 1.04e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 286 KPYACNQCGKAFACHSHLQSHERT--HTGE--KPYECD--QCGKAFSWNYCLQIHKRTHTGEKPYEC--NQCGKAF---- 353
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 354 -ACHSHLQRHEKTHTGEKPYECD--QCGKAFSWNYCLQIHKRTHTGEKPYACN--QCGKAFPRHHHLQNHERTHTGEKPY 428
Cdd:COG5048  368 nNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|.
gi 162287421 429 ECNQCGKTFAC 439
Cdd:COG5048  448 LCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
137-362 8.97e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 8.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 137 MHSRTQAGDKPCDCNTLGKSCTCNSHLQSHKRTDTR----ENPYKCNHCGKAFARHRDLQNHERTHTG-EKPYECKQCGK 211
Cdd:COG5048  218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSsssaSESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNI 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 212 AFALNSYLHIHERT--HTGE--KPFEC--SQCGKAFACHSHLQSHKRTHTGEKPYEC--NQCGKAFS-----WNYCLQIH 278
Cdd:COG5048  298 SFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQ 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 279 KRTHTGEKPYAC--NQCGKAFACHSHLQSHERTHTGEKPYECD--QCGKAFSWNYCLQIHKRTHTGEKPYECNQCGKAFA 354
Cdd:COG5048  378 YKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457


                 ....*...
gi 162287421 355 ChSHLQRH 362
Cdd:COG5048  458 D-LDLSNH 464
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 28-68 6.90e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 6.90e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 162287421   28 VTYEDVHVNFTREEWALLDPSQKSLYKDVMLETYRTLRAIG 68
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 28-64 5.60e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 5.60e-18
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 162287421  28 VTYEDVHVNFTREEWALLDPSQKSLYKDVMLETYRTL 64
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
28-69 1.43e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 1.43e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 162287421    28 VTYEDVHVNFTREEWALLDPSQKSLYKDVMLETYRTLRAIGC 69
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-439 1.04e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 286 KPYACNQCGKAFACHSHLQSHERT--HTGE--KPYECD--QCGKAFSWNYCLQIHKRTHTGEKPYEC--NQCGKAF---- 353
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 354 -ACHSHLQRHEKTHTGEKPYECD--QCGKAFSWNYCLQIHKRTHTGEKPYACN--QCGKAFPRHHHLQNHERTHTGEKPY 428
Cdd:COG5048  368 nNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|.
gi 162287421 429 ECNQCGKTFAC 439
Cdd:COG5048  448 LCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
137-362 8.97e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 8.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 137 MHSRTQAGDKPCDCNTLGKSCTCNSHLQSHKRTDTR----ENPYKCNHCGKAFARHRDLQNHERTHTG-EKPYECKQCGK 211
Cdd:COG5048  218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSsssaSESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNI 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 212 AFALNSYLHIHERT--HTGE--KPFEC--SQCGKAFACHSHLQSHKRTHTGEKPYEC--NQCGKAFS-----WNYCLQIH 278
Cdd:COG5048  298 SFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQ 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 279 KRTHTGEKPYAC--NQCGKAFACHSHLQSHERTHTGEKPYECD--QCGKAFSWNYCLQIHKRTHTGEKPYECNQCGKAFA 354
Cdd:COG5048  378 YKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457


                 ....*...
gi 162287421 355 ChSHLQRH 362
Cdd:COG5048  458 D-LDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
358-382 1.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.68e-04
                          10        20
                  ....*....|....*....|....*
gi 162287421  358 HLQRHEKTHTGEKPYECDQCGKAFS 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
246-270 3.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.41e-04
                          10        20
                  ....*....|....*....|....*
gi 162287421  246 HLQSHKRTHTGEKPYECNQCGKAFS 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 28-68 6.90e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 6.90e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 162287421   28 VTYEDVHVNFTREEWALLDPSQKSLYKDVMLETYRTLRAIG 68
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 28-64 5.60e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 5.60e-18
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 162287421  28 VTYEDVHVNFTREEWALLDPSQKSLYKDVMLETYRTL 64
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
28-69 1.43e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 1.43e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 162287421    28 VTYEDVHVNFTREEWALLDPSQKSLYKDVMLETYRTLRAIGC 69
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-439 1.04e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 286 KPYACNQCGKAFACHSHLQSHERT--HTGE--KPYECD--QCGKAFSWNYCLQIHKRTHTGEKPYEC--NQCGKAF---- 353
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 354 -ACHSHLQRHEKTHTGEKPYECD--QCGKAFSWNYCLQIHKRTHTGEKPYACN--QCGKAFPRHHHLQNHERTHTGEKPY 428
Cdd:COG5048  368 nNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|.
gi 162287421 429 ECNQCGKTFAC 439
Cdd:COG5048  448 LCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
137-362 8.97e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 8.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 137 MHSRTQAGDKPCDCNTLGKSCTCNSHLQSHKRTDTR----ENPYKCNHCGKAFARHRDLQNHERTHTG-EKPYECKQCGK 211
Cdd:COG5048  218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSsssaSESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNI 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 212 AFALNSYLHIHERT--HTGE--KPFEC--SQCGKAFACHSHLQSHKRTHTGEKPYEC--NQCGKAFS-----WNYCLQIH 278
Cdd:COG5048  298 SFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQ 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 279 KRTHTGEKPYAC--NQCGKAFACHSHLQSHERTHTGEKPYECD--QCGKAFSWNYCLQIHKRTHTGEKPYECNQCGKAFA 354
Cdd:COG5048  378 YKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457


                 ....*...
gi 162287421 355 ChSHLQRH 362
Cdd:COG5048  458 D-LDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
230-295 7.92e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 7.92e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 162287421 230 KPFECSQCGKAFACHSHLQSHKRTHTGEKPYECNQ--CGKAFSWNYCLQIHKRTHTGEKPYACNQCGK 295
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-351 1.00e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.00e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 162287421 286 KPYACNQCGKAFACHSHLQSHERTHTGEKPYEC--DQCGKAFSWNYCLQIHKRTHTGEKPYECNQCGK 351
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
358-382 1.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.68e-04
                          10        20
                  ....*....|....*....|....*
gi 162287421  358 HLQRHEKTHTGEKPYECDQCGKAFS 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
302-326 2.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.86e-04
                          10        20
                  ....*....|....*....|....*
gi 162287421  302 HLQSHERTHTGEKPYECDQCGKAFS 326
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
246-270 3.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.41e-04
                          10        20
                  ....*....|....*....|....*
gi 162287421  246 HLQSHKRTHTGEKPYECNQCGKAFS 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
160-449 3.65e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 160 NSHLQSHKRTDTREN------PYKCNHCGKAFARHRDLQNHERTHTGEKPYEC--KQCGKAFALNSYLHIHERTHTGEKP 231
Cdd:COG5048   12 NNSVLSSTPKSTLKSlsnaprPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 232 FECS-QCGKAFACHSHLQSHKRTHTGEKPYECNQCGKAFSWNYCLQIHKRTHT---GEKPYACNQCGKAFACHSHLQS-H 306
Cdd:COG5048   92 DLNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHPpL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 307 ERTHTGEKPYECDQcgkafswnycLQIHKRTHTGEKPYECNQCGKAFACHSHLQRHEKTHTGEKPYECDQCGKAFSWNYC 386
Cdd:COG5048  172 PANSLSKDPSSNLS----------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLL 241

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162287421 387 LQIHKRT------HTGEKPYACNQCGKAFPRHHHLQNHERTHTG-EKPYECNQCGKTFACHSAFQRHKRT 449
Cdd:COG5048  242 SQSPSSLsssdssSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRS 311
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-439 4.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.15e-04
                          10        20
                  ....*....|....*....|....*.
gi 162287421  414 HLQNHERTHTGEKPYECNQCGKTFAC 439
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
190-214 6.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.91e-04
                          10        20
                  ....*....|....*....|....*
gi 162287421  190 DLQNHERTHTGEKPYECKQCGKAFA 214
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-355 9.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.19e-04
                          10        20
                  ....*....|....*....|....*
gi 162287421  331 LQIHKRTHTGEKPYECNQCGKAFAC 355
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-299 1.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|....*
gi 162287421  275 LQIHKRTHTGEKPYACNQCGKAFAC 299
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-409 4.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.05e-03
                          10        20
                  ....*....|....*....|...
gi 162287421  387 LQIHKRTHTGEKPYACNQCGKAF 409
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
222-243 4.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.83e-03
                          10        20
                  ....*....|....*....|..
gi 162287421  222 HERTHTGEKPFECSQCGKAFAC 243
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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