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Conserved domains on  [gi|85719305|ref|NP_001034277|]
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ras-responsive element-binding protein 1 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
111-136 1.20e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 1.20e-05
                           10        20
                   ....*....|....*....|....*.
gi 85719305    111 SLDRHMLVHSGERPYKCTVCGQSFTT 136
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
669-693 2.93e-05

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 41.77  E-value: 2.93e-05
                           10        20
                   ....*....|....*....|....*
gi 85719305    669 YQCNICDYIAADKAALIRHIRTHSG 693
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-244 1.05e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85719305   64 SSYNCPLCEKICTTQHQLTMHIRQHNTDTGGAD-HAC--SICGKSLSSASSLDRHMLVHSGERPYKC--TVCGQSFTTNG 138
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKpFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85719305  139 NMHRHMKIHEKDTNSTTAAAPPSPLKRRRLSSKRKLShdaesedpgpakkmvedgQSGDLDKMSDEI--FHCPVCFKEFV 216
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNL------------------SLHIITHLSFRPynCKNPPCSKSFN 429

                        170       180
                 ....*....|....*....|....*....
gi 85719305  217 CKYELETHMETHSD-NPLRCDICCVTFRT 244
Cdd:COG5048  430 RHYNLIPHKKIHTNhAPLLCSILKSFRRD 458
ZnF_C2H2 smart00355
zinc finger;
1253-1273 8.14e-03

zinc finger;


:

Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 8.14e-03
                            10        20
                    ....*....|....*....|.
gi 85719305    1253 CPHCPRVFPWASSLQRHMLTH 1273
Cdd:smart00355    3 CPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
111-136 1.20e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 1.20e-05
                           10        20
                   ....*....|....*....|....*.
gi 85719305    111 SLDRHMLVHSGERPYKCTVCGQSFTT 136
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
669-693 2.93e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 41.77  E-value: 2.93e-05
                           10        20
                   ....*....|....*....|....*
gi 85719305    669 YQCNICDYIAADKAALIRHIRTHSG 693
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-244 1.05e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85719305   64 SSYNCPLCEKICTTQHQLTMHIRQHNTDTGGAD-HAC--SICGKSLSSASSLDRHMLVHSGERPYKC--TVCGQSFTTNG 138
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKpFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85719305  139 NMHRHMKIHEKDTNSTTAAAPPSPLKRRRLSSKRKLShdaesedpgpakkmvedgQSGDLDKMSDEI--FHCPVCFKEFV 216
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNL------------------SLHIITHLSFRPynCKNPPCSKSFN 429

                        170       180
                 ....*....|....*....|....*....
gi 85719305  217 CKYELETHMETHSD-NPLRCDICCVTFRT 244
Cdd:COG5048  430 RHYNLIPHKKIHTNhAPLLCSILKSFRRD 458
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 206-228 1.65e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 37.24  E-value: 1.65e-03
                           10        20
                   ....*....|....*....|...
gi 85719305    206 FHCPVCFKEFVCKYELETHMETH 228
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
ZnF_C2H2 smart00355
zinc finger;
125-147 2.96e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.29  E-value: 2.96e-03
                            10        20
                    ....*....|....*....|...
gi 85719305     125 YKCTVCGQSFTTNGNMHRHMKIH 147
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
ZnF_C2H2 smart00355
zinc finger;
1253-1273 8.14e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 8.14e-03
                            10        20
                    ....*....|....*....|.
gi 85719305    1253 CPHCPRVFPWASSLQRHMLTH 1273
Cdd:smart00355    3 CPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
111-136 1.20e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 1.20e-05
                           10        20
                   ....*....|....*....|....*.
gi 85719305    111 SLDRHMLVHSGERPYKCTVCGQSFTT 136
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
669-693 2.93e-05

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 41.77  E-value: 2.93e-05
                           10        20
                   ....*....|....*....|....*
gi 85719305    669 YQCNICDYIAADKAALIRHIRTHSG 693
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 125-147 1.03e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 1.03e-04
                           10        20
                   ....*....|....*....|...
gi 85719305    125 YKCTVCGQSFTTNGNMHRHMKIH 147
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-244 1.05e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85719305   64 SSYNCPLCEKICTTQHQLTMHIRQHNTDTGGAD-HAC--SICGKSLSSASSLDRHMLVHSGERPYKC--TVCGQSFTTNG 138
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKpFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85719305  139 NMHRHMKIHEKDTNSTTAAAPPSPLKRRRLSSKRKLShdaesedpgpakkmvedgQSGDLDKMSDEI--FHCPVCFKEFV 216
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNL------------------SLHIITHLSFRPynCKNPPCSKSFN 429

                        170       180
                 ....*....|....*....|....*....
gi 85719305  217 CKYELETHMETHSD-NPLRCDICCVTFRT 244
Cdd:COG5048  430 RHYNLIPHKKIHTNhAPLLCSILKSFRRD 458
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 206-228 1.65e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 37.24  E-value: 1.65e-03
                           10        20
                   ....*....|....*....|...
gi 85719305    206 FHCPVCFKEFVCKYELETHMETH 228
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
ZnF_C2H2 smart00355
zinc finger;
125-147 2.96e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.29  E-value: 2.96e-03
                            10        20
                    ....*....|....*....|...
gi 85719305     125 YKCTVCGQSFTTNGNMHRHMKIH 147
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 125-147 4.16e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 36.08  E-value: 4.16e-03
                           10        20
                   ....*....|....*....|...
gi 85719305    125 YKCTVCGQSFTTNGNMHRHMKIH 147
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
683-704 4.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 4.62e-03
                           10        20
                   ....*....|....*....|..
gi 85719305    683 ALIRHIRTHSGERPYICKICHY 704
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGK 22
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 97-119 5.64e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 5.64e-03
                           10        20
                   ....*....|....*....|...
gi 85719305     97 HACSICGKSLSSASSLDRHMLVH 119
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 669-691 7.72e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 7.72e-03
                           10        20
                   ....*....|....*....|...
gi 85719305    669 YQCNICDYIAADKAALIRHIRTH 691
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
1253-1273 8.14e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 8.14e-03
                            10        20
                    ....*....|....*....|.
gi 85719305    1253 CPHCPRVFPWASSLQRHMLTH 1273
Cdd:smart00355    3 CPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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