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Conserved domains on  [gi|169646737|ref|NP_001014419|]
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uncharacterized protein LOC433804 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 1.41e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.41e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 169646737   12 LLTFKDVALDFSLEEWERLSFAQRTLYIDVMLENYNNLLFV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-519 5.69e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 5.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 207 KKPYKSSKSDKCFTHQIHLRSHQGIHTGEKPHKCS--ECDKCFTHKFNLRAHQRIHTGEKLYKCSecDKCFTHKSRLNYH 284
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 285 QRIHTGEKPhkcSECDKCFTHKFNLRAHQIIHtgEKPHKCSECDKCFTHKFNLRAHQRIHTGEKPYKCS--ECDKCFTRK 362
Cdd:COG5048  109 SLSSSSSNS---NDNNLLSSHSLPPSSRDPQL--PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPanSLSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 363 FHLGIHHRIHTGEKPYKCSECDKCFTGKGSLRIHQRIHIGEKPYKCSECDKCFTGKGSLRIHQRIHTGERPHKCSECDKC 442
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 443 FTGK------GSLRIHQRMHTG-EKPYKCSECDKCFTQKSHLNIHQ--GIHTGE--KPYKCSE--CDKCFTHKSHLINHQ 509
Cdd:COG5048  264 SLPTassqssSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330
                 ....*....|
gi 169646737 510 KIHTGEKPYK 519
Cdd:COG5048  344 LLHTSISPAK 353
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 1.41e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.41e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 169646737   12 LLTFKDVALDFSLEEWERLSFAQRTLYIDVMLENYNNLLFV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-55 2.28e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.09  E-value: 2.28e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 169646737    13 LTFKDVALDFSLEEWERLSFAQRTLYIDVMLENYNNLLFVENH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 3.29e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 66.42  E-value: 3.29e-14
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 169646737  13 LTFKDVALDFSLEEWERLSFAQRTLYIDVMLENYNNLLF 51
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-519 5.69e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 5.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 207 KKPYKSSKSDKCFTHQIHLRSHQGIHTGEKPHKCS--ECDKCFTHKFNLRAHQRIHTGEKLYKCSecDKCFTHKSRLNYH 284
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 285 QRIHTGEKPhkcSECDKCFTHKFNLRAHQIIHtgEKPHKCSECDKCFTHKFNLRAHQRIHTGEKPYKCS--ECDKCFTRK 362
Cdd:COG5048  109 SLSSSSSNS---NDNNLLSSHSLPPSSRDPQL--PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPanSLSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 363 FHLGIHHRIHTGEKPYKCSECDKCFTGKGSLRIHQRIHIGEKPYKCSECDKCFTGKGSLRIHQRIHTGERPHKCSECDKC 442
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 443 FTGK------GSLRIHQRMHTG-EKPYKCSECDKCFTQKSHLNIHQ--GIHTGE--KPYKCSE--CDKCFTHKSHLINHQ 509
Cdd:COG5048  264 SLPTassqssSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330
                 ....*....|
gi 169646737 510 KIHTGEKPYK 519
Cdd:COG5048  344 LLHTSISPAK 353
zf-H2C2_2 pfam13465
Zinc-finger double domain;
336-361 8.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 169646737  336 NLRAHQRIHTGEKPYKCSECDKCFTR 361
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 1.41e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.41e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 169646737   12 LLTFKDVALDFSLEEWERLSFAQRTLYIDVMLENYNNLLFV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-55 2.28e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.09  E-value: 2.28e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 169646737    13 LTFKDVALDFSLEEWERLSFAQRTLYIDVMLENYNNLLFVENH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 3.29e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 66.42  E-value: 3.29e-14
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 169646737  13 LTFKDVALDFSLEEWERLSFAQRTLYIDVMLENYNNLLF 51
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-519 5.69e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 5.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 207 KKPYKSSKSDKCFTHQIHLRSHQGIHTGEKPHKCS--ECDKCFTHKFNLRAHQRIHTGEKLYKCSecDKCFTHKSRLNYH 284
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 285 QRIHTGEKPhkcSECDKCFTHKFNLRAHQIIHtgEKPHKCSECDKCFTHKFNLRAHQRIHTGEKPYKCS--ECDKCFTRK 362
Cdd:COG5048  109 SLSSSSSNS---NDNNLLSSHSLPPSSRDPQL--PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPanSLSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 363 FHLGIHHRIHTGEKPYKCSECDKCFTGKGSLRIHQRIHIGEKPYKCSECDKCFTGKGSLRIHQRIHTGERPHKCSECDKC 442
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 443 FTGK------GSLRIHQRMHTG-EKPYKCSECDKCFTQKSHLNIHQ--GIHTGE--KPYKCSE--CDKCFTHKSHLINHQ 509
Cdd:COG5048  264 SLPTassqssSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330
                 ....*....|
gi 169646737 510 KIHTGEKPYK 519
Cdd:COG5048  344 LLHTSISPAK 353
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
38-369 1.32e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737  38 YIDVMLENYNNLLFVENHCIRGKYRKVLDQD-SQYIVHEHMNIQEKSSKWDKLSKVLLDSPQYTPYKTYHSSLQywnQKR 116
Cdd:COG5048  132 SRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPL---SSS 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 117 LKPRNTKEVCKYNDSVNSVSLfstISLNQGIHMQKKKHKRNAEfekvfvsKHKDMVKQKNTGVNPYKCSEFHKYLTQREK 196
Cdd:COG5048  209 YSIPSSSSDQNLENSSSSLPL---TTNSQLSPKSLLSQSPSSL-------SSSDSSSSASESPRSSLPTASSQSSSPNES 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 197 LQTQQRIYhgKKPYKSSKSDKCFTHQIHLRSHQ--GIHTGE--KPHKCSE--CDKCFTHKFNLRAHQRIHTGEKLYKCSE 270
Cdd:COG5048  279 DSSSEKGF--SLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKL 356

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 271 CDKCFTHKSRLN-------YHQRIHTGEKPHKC--SECDKCFTHKFNLRAHQIIHTGEKPH--KCSECDKCFTHKFNLRA 339
Cdd:COG5048  357 LNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIP 436

                        330       340       350
                 ....*....|....*....|....*....|
gi 169646737 340 HQRIHTGEKPYKCseCDKCFTRKFHLGIHH 369
Cdd:COG5048  437 HKKIHTNHAPLLC--SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-465 3.51e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 220 THQIHLRSHQGIHTGEKPHKCSECDKCFTHKFNLRAHQRIHTGEKLYKCSECDKCFTHKSRLNYHQRIHTGEKPHKCSEC 299
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 300 DKCFTHKFNLRAHQIIHTGE-------KPHKCSECDKCFTHKFNLRAHQR--IHTGE--KPYKCSE--CDKCFTRKFHLG 366
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 367 IHHRIHTGEKPYKCSEC------DKCFTGKGSLRIHQRIHIGEKPYKC---SECDKCFTGKGSLRIHQRIHTGERPH--K 435
Cdd:COG5048  341 RHILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYncK 420

                        250       260       270
                 ....*....|....*....|....*....|
gi 169646737 436 CSECDKCFTGKGSLRIHQRMHTGEKPYKCS 465
Cdd:COG5048  421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
336-361 8.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 169646737  336 NLRAHQRIHTGEKPYKCSECDKCFTR 361
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 346-424 1.33e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 346 GEKPYKCS--ECDKCFTRKFHLGiHHRIHtgekpykcSECDKCFTGKGSLRIHQRIHIGEKPYKCSECDKCFTGKGSLRI 423
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLK-YHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 169646737 424 H 424
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
448-473 1.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 169646737  448 SLRIHQRMHTGEKPYKCSECDKCFTQ 473
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
280-305 2.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 169646737  280 RLNYHQRIHTGEKPHKCSECDKCFTH 305
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 290-369 3.21e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 290 GEKPHKCS--ECDKCFTHKFNLRAHQII-HTGEKPHKCSECDKcfthkfnlraHQRIHTGEKPYKCSECDKCFTR----K 362
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNlnglK 415


                 ....*..
gi 169646737 363 FHLGIHH 369
Cdd:COG5189  416 YHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
224-249 4.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.05e-03
                          10        20
                  ....*....|....*....|....*.
gi 169646737  224 HLRSHQGIHTGEKPHKCSECDKCFTH 249
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
308-333 4.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 169646737  308 NLRAHQIIHTGEKPHKCSECDKCFTH 333
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
420-444 7.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.16e-03
                          10        20
                  ....*....|....*....|....*
gi 169646737  420 SLRIHQRIHTGERPHKCSECDKCFT 444
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 262-340 9.10e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 9.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169646737 262 GEKLYKCS--ECDKCFTHKSRLNYHQRI-HTGEKPHKCSECDKcfthkfnlraHQIIHTGEKPHKCSECDKCFTHKFNLR 338
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ..
gi 169646737 339 AH 340
Cdd:COG5189  416 YH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
392-416 9.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.52e-03
                          10        20
                  ....*....|....*....|....*
gi 169646737  392 SLRIHQRIHIGEKPYKCSECDKCFT 416
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
252-277 1.00e-02

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 1.00e-02
                          10        20
                  ....*....|....*....|....*.
gi 169646737  252 NLRAHQRIHTGEKLYKCSECDKCFTH 277
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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