|
Name |
Accession |
Description |
Interval |
E-value |
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
635-952 |
2.09e-40 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 151.74 E-value: 2.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 635 LDLKETDLGVNGLKTLCEALKCkgckLRVLRLASCDLNVARCQKLSNALQTNRSL--VFLNLSLNNLSNDGVKSLCEVLE 712
Cdd:cd00116 3 LSLKGELLKTERATELLPKLLC----LQVLRLEGNTLGEEAAKALASALRPQPSLkeLCLSLNETGRIPRGLQSLLQGLT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 713 NpNSSLERLALASCGLTKAGCKVLSSaLTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQCTLQSLVLRSCSFTPIGSEH 792
Cdd:cd00116 79 K-GCGLQELDLSDNALGPDGCGVLES-LLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 793 LSTALLHNRSLVHLDLGQNKLADNGVKLLCHSLQQpHCNLQELELMSCVLTSKACGDLASVLVNNSNLWSLDLGHNILDD 872
Cdd:cd00116 157 LAKALRANRDLKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 873 AGLNILCDALRNPNCHVQRLGLENCGLTPGCCQDLLGILSNNKSVIQMNLMKNALDHESIKNLCKVLRSPTCKMEFLALD 952
Cdd:cd00116 236 AGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVK 315
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
81-249 |
2.96e-38 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 140.52 E-value: 2.96e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 81 QTVVLQGAAGIGKTTLLKKAVLEWADGNLYQQFTHVFYLNGKEISQVKEK-SFAQLISKHWPSSEGPIEQV----LSKPS 155
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNArSLADLLFSQWPEPAAPVSEVwaviLELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 156 SLLFIIDSFDELDFSFEEPQFALckdwtqisPVSFLISSLLRKVMLPESYLLVATRSTAWKRLVPLLQKPQRVKLSGLSK 235
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDGPC--------PVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEPRYLEVRGFSE 152
|
170
....*....|....
gi 228008318 236 NARMDYIHHLLKDK 249
Cdd:pfam05729 153 SDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
383-500 |
8.83e-29 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 111.61 E-value: 8.83e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 383 HLHVQEFFAALFYLLRENLEEQDYPSEPFENLY------LLLESNHIHDPHLEQMKCFLFGLLNKDRVRQLEETFNLTIS 456
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLRKreslksLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLGCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 228008318 457 MEVREELLACLEglEKDDSSLSQLRFQDLLHCIYETQDQEFITQ 500
Cdd:pfam17776 81 SEIKQELLQWIK--SLIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
5-583 |
3.54e-20 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
:
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 96.80 E-value: 3.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 5 DDEMEYEASKEETVSEDKDFDDGIDYRTVIKENIFTMWYKTSLHGEFATLNCVITPkdQNLLQHIFDEDIQTSEAPQT-- 82
Cdd:COG5635 105 LALLELAALLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLYVP--LNLLERIESLKRLELLEAKKkr 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 83 VVLQGAAGIGKTTLLKKAVLEWADGNLYQQFTHVFYLNGKEISqvKEKSFAQLISKHWPSSEGPIEQVLS---KPSSLLF 159
Cdd:COG5635 183 LLILGEPGSGKTTLLRYLALELAERYLDAEDPIPILIELRDLA--EEASLEDLLAEALEKRGGEPEDALErllRNGRLLL 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 160 IIDSFDELdfsFEEPQFALCKDWtqispvsflISSLLRKvmLPESYLLVATRSTAWKRlvPLLQKPQRVKLSGLSKNARM 239
Cdd:COG5635 261 LLDGLDEV---PDEADRDEVLNQ---------LRRFLER--YPKARVIITSRPEGYDS--SELEGFEVLELAPLSDEQIE 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 240 DYIHHLLKDKAW-ATSAIYSLRMNWRLFHMCHVCHMCQMICAVLKGQvekgGRVEEtckTSTALFTYYICSLF-----PR 313
Cdd:COG5635 325 EFLKKWFEATERkAERLLEALEENPELRELARNPLLLTLLALLLRER----GELPD---TRAELYEQFVELLLerwdeQR 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 314 IPVGCVTLPNETLLRSLCKAAVegiWTMKHVLY-------QQNLRKHELTREDILLFLDAKVLQQD---TEYENCYMFTH 383
Cdd:COG5635 398 GLTIYRELSREELRELLSELAL---AMQENGRTefareelEEILREYLGRRKDAEALLDELLLRTGllvERGEGRYSFAH 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 384 LHVQEFFAALFYLlrenleeqdypsEPFENLYLLLESNHIHDPHLEQMKCFLFGLLNKDRVRQLEETFNLTISMEVREEL 463
Cdd:COG5635 475 RSFQEYLAARALV------------EELDEELLELLAEHLEDPRWREVLLLLAGLLDDVKQIKELIDALLARDDAAALAL 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 464 LACLEGLEKDDSSLSQLRFQDLLHCIYETQDQEFITQALMYFQKIIVRVDEEPQLRIYSFCLKHCHTLKTMRLTARADLK 543
Cdd:COG5635 543 AAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLL 622
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 228008318 544 NMLDTAEMCLEGAAVQVIHYWQDLFSVLHTNESLIEMDLY 583
Cdd:COG5635 623 ALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLL 662
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
635-952 |
2.09e-40 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 151.74 E-value: 2.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 635 LDLKETDLGVNGLKTLCEALKCkgckLRVLRLASCDLNVARCQKLSNALQTNRSL--VFLNLSLNNLSNDGVKSLCEVLE 712
Cdd:cd00116 3 LSLKGELLKTERATELLPKLLC----LQVLRLEGNTLGEEAAKALASALRPQPSLkeLCLSLNETGRIPRGLQSLLQGLT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 713 NpNSSLERLALASCGLTKAGCKVLSSaLTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQCTLQSLVLRSCSFTPIGSEH 792
Cdd:cd00116 79 K-GCGLQELDLSDNALGPDGCGVLES-LLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 793 LSTALLHNRSLVHLDLGQNKLADNGVKLLCHSLQQpHCNLQELELMSCVLTSKACGDLASVLVNNSNLWSLDLGHNILDD 872
Cdd:cd00116 157 LAKALRANRDLKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 873 AGLNILCDALRNPNCHVQRLGLENCGLTPGCCQDLLGILSNNKSVIQMNLMKNALDHESIKNLCKVLRSPTCKMEFLALD 952
Cdd:cd00116 236 AGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVK 315
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
81-249 |
2.96e-38 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 140.52 E-value: 2.96e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 81 QTVVLQGAAGIGKTTLLKKAVLEWADGNLYQQFTHVFYLNGKEISQVKEK-SFAQLISKHWPSSEGPIEQV----LSKPS 155
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNArSLADLLFSQWPEPAAPVSEVwaviLELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 156 SLLFIIDSFDELDFSFEEPQFALckdwtqisPVSFLISSLLRKVMLPESYLLVATRSTAWKRLVPLLQKPQRVKLSGLSK 235
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDGPC--------PVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEPRYLEVRGFSE 152
|
170
....*....|....
gi 228008318 236 NARMDYIHHLLKDK 249
Cdd:pfam05729 153 SDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
383-500 |
8.83e-29 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 111.61 E-value: 8.83e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 383 HLHVQEFFAALFYLLRENLEEQDYPSEPFENLY------LLLESNHIHDPHLEQMKCFLFGLLNKDRVRQLEETFNLTIS 456
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLRKreslksLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLGCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 228008318 457 MEVREELLACLEglEKDDSSLSQLRFQDLLHCIYETQDQEFITQ 500
Cdd:pfam17776 81 SEIKQELLQWIK--SLIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
629-883 |
5.73e-22 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 99.86 E-value: 5.73e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 629 NKKVTHLDLKETDLGVNGLKTLCEALKcKGCKLRVLRLASCDLNVARCQKLSNALQTNRSLVFLNLSLNNLSNDGVKSLC 708
Cdd:COG5238 179 NNSVETVYLGCNQIGDEGIEELAEALT-QNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 709 EVLENpNSSLERLALASCGLTKAGCKVLSSALTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQcTLQSLVLRSCSFTPI 788
Cdd:COG5238 258 EALKN-NTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK-TLHTLNLAYNGIGAQ 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 789 GSEHLSTALLHNRSLVHLDLGQNKLADNGVKLLCHSLQQpHCNLQELELMSCVLTSKACGDLASVLVNNsNLWSLDLGHN 868
Cdd:COG5238 336 GAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEG-NTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGN 413
|
250
....*....|....*...
gi 228008318 869 ILDD---AGLNILCDALR 883
Cdd:COG5238 414 LIGAeaqQRLEQLLERIK 431
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
5-583 |
3.54e-20 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 96.80 E-value: 3.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 5 DDEMEYEASKEETVSEDKDFDDGIDYRTVIKENIFTMWYKTSLHGEFATLNCVITPkdQNLLQHIFDEDIQTSEAPQT-- 82
Cdd:COG5635 105 LALLELAALLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLYVP--LNLLERIESLKRLELLEAKKkr 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 83 VVLQGAAGIGKTTLLKKAVLEWADGNLYQQFTHVFYLNGKEISqvKEKSFAQLISKHWPSSEGPIEQVLS---KPSSLLF 159
Cdd:COG5635 183 LLILGEPGSGKTTLLRYLALELAERYLDAEDPIPILIELRDLA--EEASLEDLLAEALEKRGGEPEDALErllRNGRLLL 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 160 IIDSFDELdfsFEEPQFALCKDWtqispvsflISSLLRKvmLPESYLLVATRSTAWKRlvPLLQKPQRVKLSGLSKNARM 239
Cdd:COG5635 261 LLDGLDEV---PDEADRDEVLNQ---------LRRFLER--YPKARVIITSRPEGYDS--SELEGFEVLELAPLSDEQIE 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 240 DYIHHLLKDKAW-ATSAIYSLRMNWRLFHMCHVCHMCQMICAVLKGQvekgGRVEEtckTSTALFTYYICSLF-----PR 313
Cdd:COG5635 325 EFLKKWFEATERkAERLLEALEENPELRELARNPLLLTLLALLLRER----GELPD---TRAELYEQFVELLLerwdeQR 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 314 IPVGCVTLPNETLLRSLCKAAVegiWTMKHVLY-------QQNLRKHELTREDILLFLDAKVLQQD---TEYENCYMFTH 383
Cdd:COG5635 398 GLTIYRELSREELRELLSELAL---AMQENGRTefareelEEILREYLGRRKDAEALLDELLLRTGllvERGEGRYSFAH 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 384 LHVQEFFAALFYLlrenleeqdypsEPFENLYLLLESNHIHDPHLEQMKCFLFGLLNKDRVRQLEETFNLTISMEVREEL 463
Cdd:COG5635 475 RSFQEYLAARALV------------EELDEELLELLAEHLEDPRWREVLLLLAGLLDDVKQIKELIDALLARDDAAALAL 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 464 LACLEGLEKDDSSLSQLRFQDLLHCIYETQDQEFITQALMYFQKIIVRVDEEPQLRIYSFCLKHCHTLKTMRLTARADLK 543
Cdd:COG5635 543 AAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLL 622
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 228008318 544 NMLDTAEMCLEGAAVQVIHYWQDLFSVLHTNESLIEMDLY 583
Cdd:COG5635 623 ALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLL 662
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
326-381 |
2.55e-12 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 62.58 E-value: 2.55e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 228008318 326 LLRSLCKAAVEGIWTMKHVLYQQNLRKHELTREDILLFLDAKVLQQDTEYENCYMF 381
Cdd:pfam17779 2 LLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQKDLGCEKVYSF 57
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
80-167 |
1.54e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 40.05 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 80 PQTVVLQGAAGIGKTTLLKKAVlewadGNLYQQFTHVFYLNGKEISQVKEKSFAQLISKHWPSSEGPIEQV------LSK 153
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALA-----RELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLrlalalARK 76
|
90
....*....|....
gi 228008318 154 PSSLLFIIDSFDEL 167
Cdd:smart00382 77 LKPDVLILDEITSL 90
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
635-952 |
2.09e-40 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 151.74 E-value: 2.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 635 LDLKETDLGVNGLKTLCEALKCkgckLRVLRLASCDLNVARCQKLSNALQTNRSL--VFLNLSLNNLSNDGVKSLCEVLE 712
Cdd:cd00116 3 LSLKGELLKTERATELLPKLLC----LQVLRLEGNTLGEEAAKALASALRPQPSLkeLCLSLNETGRIPRGLQSLLQGLT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 713 NpNSSLERLALASCGLTKAGCKVLSSaLTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQCTLQSLVLRSCSFTPIGSEH 792
Cdd:cd00116 79 K-GCGLQELDLSDNALGPDGCGVLES-LLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 793 LSTALLHNRSLVHLDLGQNKLADNGVKLLCHSLQQpHCNLQELELMSCVLTSKACGDLASVLVNNSNLWSLDLGHNILDD 872
Cdd:cd00116 157 LAKALRANRDLKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 873 AGLNILCDALRNPNCHVQRLGLENCGLTPGCCQDLLGILSNNKSVIQMNLMKNALDHESIKNLCKVLRSPTCKMEFLALD 952
Cdd:cd00116 236 AGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVK 315
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
81-249 |
2.96e-38 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 140.52 E-value: 2.96e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 81 QTVVLQGAAGIGKTTLLKKAVLEWADGNLYQQFTHVFYLNGKEISQVKEK-SFAQLISKHWPSSEGPIEQV----LSKPS 155
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNArSLADLLFSQWPEPAAPVSEVwaviLELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 156 SLLFIIDSFDELDFSFEEPQFALckdwtqisPVSFLISSLLRKVMLPESYLLVATRSTAWKRLVPLLQKPQRVKLSGLSK 235
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDGPC--------PVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEPRYLEVRGFSE 152
|
170
....*....|....
gi 228008318 236 NARMDYIHHLLKDK 249
Cdd:pfam05729 153 SDRKQYVRKYFSDE 166
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
626-897 |
1.19e-31 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 126.32 E-value: 1.19e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 626 LASNKKVTHLDL--KETDLGVNGLKTLCEALKcKGCKLRVLRLASCDLNVARCQKLSNALQtNRSLVFLNLSLNNLSNDG 703
Cdd:cd00116 47 LRPQPSLKELCLslNETGRIPRGLQSLLQGLT-KGCGLQELDLSDNALGPDGCGVLESLLR-SSSLQELKLNNNGLGDRG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 704 VKSLCEVLENPNSSLERLALASCGLTKAGCKVLSSALTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHpQCTLQSLVLRSC 783
Cdd:cd00116 125 LRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNN 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 784 SFTPIGSEHLSTALLHNRSLVHLDLGQNKLADNGVKLLCHSLQQPHCNLQELELMSCVLTSKACGDLASVLVNNSNLWSL 863
Cdd:cd00116 204 GLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLEL 283
|
250 260 270
....*....|....*....|....*....|....
gi 228008318 864 DLGHNILDDAGLNILCDALRNPNCHVQRLGLENC 897
Cdd:cd00116 284 DLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
566-840 |
1.87e-29 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 120.15 E-value: 1.87e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 566 DLFSVLHTNESLIEMDL--YESRLDESLMKILNEELSHpKCKLQKLIFRAVDFL-NGCQDFTFLASNKKVTHLDLKETDL 642
Cdd:cd00116 42 ALASALRPQPSLKELCLslNETGRIPRGLQSLLQGLTK-GCGLQELDLSDNALGpDGCGVLESLLRSSSLQELKLNNNGL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 643 GVNGLKTLCEALKCKGCKLRVLRLASCDLNVARCQKLSNALQTNRSLVFLNLSLNNLSNDGVKSLCEVLENpNSSLERLA 722
Cdd:cd00116 121 GDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKA-NCNLEVLD 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 723 LASCGLTKAGCKVLSSALTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQCTLQSLVLRSCSFTPIGSEHLSTALLHNRS 802
Cdd:cd00116 200 LNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES 279
|
250 260 270
....*....|....*....|....*....|....*...
gi 228008318 803 LVHLDLGQNKLADNGVKLLCHSLQQPHCNLQELELMSC 840
Cdd:cd00116 280 LLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
383-500 |
8.83e-29 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 111.61 E-value: 8.83e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 383 HLHVQEFFAALFYLLRENLEEQDYPSEPFENLY------LLLESNHIHDPHLEQMKCFLFGLLNKDRVRQLEETFNLTIS 456
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLRKreslksLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLGCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 228008318 457 MEVREELLACLEglEKDDSSLSQLRFQDLLHCIYETQDQEFITQ 500
Cdd:pfam17776 81 SEIKQELLQWIK--SLIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
629-883 |
5.73e-22 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 99.86 E-value: 5.73e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 629 NKKVTHLDLKETDLGVNGLKTLCEALKcKGCKLRVLRLASCDLNVARCQKLSNALQTNRSLVFLNLSLNNLSNDGVKSLC 708
Cdd:COG5238 179 NNSVETVYLGCNQIGDEGIEELAEALT-QNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 709 EVLENpNSSLERLALASCGLTKAGCKVLSSALTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQcTLQSLVLRSCSFTPI 788
Cdd:COG5238 258 EALKN-NTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK-TLHTLNLAYNGIGAQ 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 789 GSEHLSTALLHNRSLVHLDLGQNKLADNGVKLLCHSLQQpHCNLQELELMSCVLTSKACGDLASVLVNNsNLWSLDLGHN 868
Cdd:COG5238 336 GAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEG-NTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGN 413
|
250
....*....|....*...
gi 228008318 869 ILDD---AGLNILCDALR 883
Cdd:COG5238 414 LIGAeaqQRLEQLLERIK 431
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
5-583 |
3.54e-20 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 96.80 E-value: 3.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 5 DDEMEYEASKEETVSEDKDFDDGIDYRTVIKENIFTMWYKTSLHGEFATLNCVITPkdQNLLQHIFDEDIQTSEAPQT-- 82
Cdd:COG5635 105 LALLELAALLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLYVP--LNLLERIESLKRLELLEAKKkr 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 83 VVLQGAAGIGKTTLLKKAVLEWADGNLYQQFTHVFYLNGKEISqvKEKSFAQLISKHWPSSEGPIEQVLS---KPSSLLF 159
Cdd:COG5635 183 LLILGEPGSGKTTLLRYLALELAERYLDAEDPIPILIELRDLA--EEASLEDLLAEALEKRGGEPEDALErllRNGRLLL 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 160 IIDSFDELdfsFEEPQFALCKDWtqispvsflISSLLRKvmLPESYLLVATRSTAWKRlvPLLQKPQRVKLSGLSKNARM 239
Cdd:COG5635 261 LLDGLDEV---PDEADRDEVLNQ---------LRRFLER--YPKARVIITSRPEGYDS--SELEGFEVLELAPLSDEQIE 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 240 DYIHHLLKDKAW-ATSAIYSLRMNWRLFHMCHVCHMCQMICAVLKGQvekgGRVEEtckTSTALFTYYICSLF-----PR 313
Cdd:COG5635 325 EFLKKWFEATERkAERLLEALEENPELRELARNPLLLTLLALLLRER----GELPD---TRAELYEQFVELLLerwdeQR 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 314 IPVGCVTLPNETLLRSLCKAAVegiWTMKHVLY-------QQNLRKHELTREDILLFLDAKVLQQD---TEYENCYMFTH 383
Cdd:COG5635 398 GLTIYRELSREELRELLSELAL---AMQENGRTefareelEEILREYLGRRKDAEALLDELLLRTGllvERGEGRYSFAH 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 384 LHVQEFFAALFYLlrenleeqdypsEPFENLYLLLESNHIHDPHLEQMKCFLFGLLNKDRVRQLEETFNLTISMEVREEL 463
Cdd:COG5635 475 RSFQEYLAARALV------------EELDEELLELLAEHLEDPRWREVLLLLAGLLDDVKQIKELIDALLARDDAAALAL 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 464 LACLEGLEKDDSSLSQLRFQDLLHCIYETQDQEFITQALMYFQKIIVRVDEEPQLRIYSFCLKHCHTLKTMRLTARADLK 543
Cdd:COG5635 543 AAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLL 622
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 228008318 544 NMLDTAEMCLEGAAVQVIHYWQDLFSVLHTNESLIEMDLY 583
Cdd:COG5635 623 ALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLL 662
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
712-943 |
3.63e-19 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 91.39 E-value: 3.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 712 ENPNSSLERLALASCGLTKAGCKVLSSALTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQcTLQSLVLrscSFTPIGSE 791
Cdd:COG5238 176 ALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNK-SLTTLDL---SNNQIGDE 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 792 ---HLSTALLHNRSLVHLDLGQNKLADNGVKLlchslqqphcnlqelelmscvltskacgdLASVLVNNSNLWSLDLGHN 868
Cdd:COG5238 252 gviALAEALKNNTTVETLYLSGNQIGAEGAIA-----------------------------LAKALQGNTTLTSLDLSVN 302
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 228008318 869 ILDDAGLNILCDALRNpNCHVQRLGLENCGLTPGCCQDLLGILSNNKSVIQMNLMKNALDHESIKNLCKVLRSPT 943
Cdd:COG5238 303 RIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT 376
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
626-815 |
5.11e-18 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 87.92 E-value: 5.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 626 LASNKKVTHLDLKETDLGVNGLKTLCEALKcKGCKLRVLRLASCDLNVARCQKLSNALQTNRSLVFLNLSLNNLSNDGVK 705
Cdd:COG5238 232 LKGNKSLTTLDLSNNQIGDEGVIALAEALK-NNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAI 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 706 SLCEVLENpNSSLERLALASCGLTKAGCKVLSSALTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQcTLQSLVLRSCSF 785
Cdd:COG5238 311 ALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-TLRELNLGKNNI 388
|
170 180 190
....*....|....*....|....*....|
gi 228008318 786 TPIGSEHLSTALLHNRsLVHLDLGQNKLAD 815
Cdd:COG5238 389 GKQGAEALIDALQTNR-LHTLILDGNLIGA 417
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
567-785 |
3.62e-17 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 83.56 E-value: 3.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 567 LFSVLHTNESLIEMDLYESRLDESLMKILNEELSHPKCKLQKLIFRAVDFLNGCQDFT--FLASNKKVTHLDLKETDLGV 644
Cdd:cd00116 100 VLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALakALRANRDLKELNLANNGIGD 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 645 NGLKTLCEALKcKGCKLRVLRLASCDLNVARCQKLSNALQTNRSLVFLNLSLNNLSNDGVKSLCEVLENPNSSLERLALA 724
Cdd:cd00116 180 AGIRALAEGLK-ANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLS 258
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 228008318 725 SCGLTKAGCKVLSSALTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQCTLQSLVLRSCSF 785
Cdd:cd00116 259 CNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDDSF 319
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
326-381 |
2.55e-12 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 62.58 E-value: 2.55e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 228008318 326 LLRSLCKAAVEGIWTMKHVLYQQNLRKHELTREDILLFLDAKVLQQDTEYENCYMF 381
Cdd:pfam17779 2 LLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQKDLGCEKVYSF 57
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
626-770 |
8.36e-10 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 62.11 E-value: 8.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 626 LASNKKVTHLDLKETDLGVNGLKTLCEALKcKGCKLRVLRLASCDLNVARCQKLSNALQTNRSLVFLNLSLNNLSNDGVK 705
Cdd:COG5238 288 LQGNTTLTSLDLSVNRIGDEGAIALAEGLQ-GNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAI 366
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 228008318 706 SLCEVLENpNSSLERLALASCGLTKAGCKVLSSALtKSKRLTHLCLSDNVLEDEGIKLLSHTLKH 770
Cdd:COG5238 367 ALAKYLEG-NTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLER 429
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
80-167 |
1.54e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 40.05 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228008318 80 PQTVVLQGAAGIGKTTLLKKAVlewadGNLYQQFTHVFYLNGKEISQVKEKSFAQLISKHWPSSEGPIEQV------LSK 153
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALA-----RELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLrlalalARK 76
|
90
....*....|....
gi 228008318 154 PSSLLFIIDSFDEL 167
Cdd:smart00382 77 LKPDVLILDEITSL 90
|
|
| |
