NCBI Conserved Domain Search

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 207.99 E-value: 2.62e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  262 GTVTEFKHPSNFYIQLYSSEVLENMNQLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVDVLQRKAHV 341
Cdd:cd20408    1 GTVTEFKNPGEFYIQIYTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKKAGV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 50355698  342 LYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCV 391
Cdd:cd20408   81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 198.05 E-value: 4.86e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  936 ANVLEIISPALFYAIPSEMSENQEKLCVLAAELLEHCNAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLETSESDVKVL 1015
Cdd:cd20411    1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDSEVKVL 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 50355698 1016 YADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 1051
Cdd:cd20411   81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 144.91 E-value: 6.43e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  512 GHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPK 591
Cdd:cd20409    1 GRQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPS 80


                 ..
gi 50355698  592 LL 593
Cdd:cd20409   81 LL 82

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 126.31 E-value: 6.14e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698    489 DEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHvIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVL 568
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYAS-KPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 50355698    569 VGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAG 606
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 124.77 E-value: 2.32e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698    715 CMMYSPGEFYCHFLKDDalEKLDDLNQSLADYCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDY 794
Cdd:pfam00567    8 SHIESPSTFYIQPKSDS--KKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEVLFIDY 85

                           90       100       110
                   ....*....|....*....|....*....|
gi 50355698    795 GNVEEVTTDQLQAILPQFLLLPFQGMQCWL 824
Cdd:pfam00567   86 GNTETVPLSDLRPLPPELESLPPQAIKCQL 115

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 121.29 E-value: 6.30e-33

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 50355698  755 FKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQFL 813
Cdd:cd20410    1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 115.14 E-value: 6.25e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698    932 KTIAANVLEIISPALFYAIPSEmseNQEKLCVLAAELLEHCNaQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLETSESD 1011
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKS---DSKKLEKLTEELQEYYA-SKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDG 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 50355698   1012 -VKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 1051
Cdd:pfam00567   77 lVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 111.29 E-value: 1.21e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698    258 MEIKGTVTEFKHPSNFYIQlySSEVLENMNQLSTSLKETYANVVPEdGYLPVKGEVCVAKYTVDQTWNRAIVQaVDVLQR 337
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPE-SLPPAVGDGCVAAFSEDGKWYRAKIT-ESLDDG 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 50355698    338 KAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSG 378
Cdd:pfam00567   77 LVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 101.75 E-value: 2.74e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  514 KLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLL 593
Cdd:cd20411   25 KLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLE-TSDSEVKVLYADYGNTETLPLSRILPITKSHL 103

                         90
                 ....*....|...
gi 50355698  594 DLPMQALNCVLAG 606
Cdd:cd20411  104 ELPFQIIRCSLAG 116

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 95.90 E-value: 3.90e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  493 GVVAHIQTPEDFF--CQQLQSGHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAY-ASEESVLV 569
Cdd:cd20408    1 GTVTEFKNPGEFYiqIYTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVdVQQKKAGV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 50355698  570 GYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEAV 619
Cdd:cd20408   81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 93.28 E-value: 2.14e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  719 SPGEFYC-HFLKDDALEKLDDLNQSLADYC-AQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSgNVKVHFVDYGN 796
Cdd:cd20411    8 SPDLFYAlPKTGQVNVEKLKALMTELAEYCsKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDS-EVKVLYADYGN 86

                         90       100
                 ....*....|....*....|....*...
gi 50355698  797 VEEVTTDQLQAILPQFLLLPFQGMQCWL 824
Cdd:cd20411   87 TETLPLSRILPITKSHLELPFQIIRCSL 114

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 92.55 E-value: 6.21e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  481 KVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHvipRSDFYPTIGDVCCAQFSEDDQWYRASVLA 560
Cdd:cd20439    2 KEYLFKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLI---HNDPYKHGQIACVAKYSKDGKWYRAAVLK 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 50355698  561 YASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGV 607
Cdd:cd20439   79 QVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 92.43 E-value: 6.74e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  718 YSPGEFYCHFLKDDALEKLDDLNQSLAD-YCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGN-VKVHFVDYG 795
Cdd:cd20408    7 KNPGEFYIQIYTLEVLESLVKLTSQLKKtYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKkAGVFYIDYG 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 50355698  796 NVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWTKEA 838
Cdd:cd20408   87 NEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEEC 129

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 91.37 E-value: 1.34e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  271 SNFYIQLYSSEVLEN-MNQL-STSLKETyanVVPEDGYLPVKGEVCVAKYTVDQTWNRAIV-----QAVDVLQRKAHVLY 343
Cdd:cd20443    2 GRFYVQVVSDQRLSSiQQQLeGLSLKDK---ANPPGGFNPKKGELVLAQFSADNSWNRAMVvnaprQGTQSPKDEYEVFY 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 50355698  344 IDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIP 381
Cdd:cd20443   79 IDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 85.97 E-value: 3.61e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  959 EKLCVLAAELLEHCNAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLE-TSESDVKVLYADYGNIETLPLSRVQPIPASH 1037
Cdd:cd20409    2 RQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAySSEDSVLVGYIDFGNSEEVALSRLRPIPPSL 81


                 .
gi 50355698 1038 L 1038
Cdd:cd20409   82 L 82

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 85.50 E-value: 1.87e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  938 VLEIISPALFYAIPsEMSENQEKLCVLAAELLEHCNAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLETSESD--VKVL 1015
Cdd:cd20408    3 VTEFKNPGEFYIQI-YTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQkkAGVF 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 50355698 1016 YADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEGPMELNGSCS 1060
Cdd:cd20408   82 YIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWS 126

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 85.24 E-value: 2.90e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  493 GVVAHIQTPEDFFCQQlqSGHKLAELQESLSEYCGHVIPRSDFYPTI--GDVCCAQFSEDDQWYRASVLAYASEEsVLVG 570
Cdd:cd20426    3 AYATAVDSPEYFWCQF--ATEKIQCLAVKVQEAGEQVADRGNFIPSIyvGDPCIVKYSEDNHWYRALVTKINDNL-VSVR 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 50355698  571 YVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEAV 619
Cdd:cd20426   80 FVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEAN 128

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 77.89 E-value: 5.81e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  505 FCQQLQSGHKLAELQESLSEYC--GHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVL------AYASEESVLVGYVDYGN 576
Cdd:cd20443    4 FYVQVVSDQRLSSIQQQLEGLSlkDKANPPGGFNPKKGELVLAQFSADNSWNRAMVVnaprqgTQSPKDEYEVFYIDYGN 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 50355698  577 FEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 609
Cdd:cd20443   84 QETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 75.03 E-value: 2.35e-16

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50355698  977 GQPAYRPRTGDACCAKYTNDDFWYRAIVlETSESD--VKVLYADYGNIETLPLSRVQPIPAS 1036
Cdd:cd20433   22 LPGSYTPRKGDLCAAKFVEDGEWYRAKV-EKVEGDkkVHVLYIDYGNREVLPSTRLAALPPA 82

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 76.38 E-value: 3.89e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  934 IAANVLEIISPALFYAIPSemSENQEKLCVLAAELLEHcNAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLETSESDVK 1013
Cdd:cd20426    1 IEAYATAVDSPEYFWCQFA--TEKIQCLAVKVQEAGEQ-VADRGNFIPSIYVGDPCIVKYSEDNHWYRALVTKINDNLVS 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 50355698 1014 VLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEGPMELNGSCSQ 1061
Cdd:cd20426   78 VRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSD 125

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 74.26 E-value: 4.93e-16

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50355698  283 LEN-MNQLSTslkETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVDVlQRKAHVLYIDYGNEEMIPIDSVHPL 360
Cdd:cd20433    5 LEKlMEKLRF---EIASNPPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEG-DKKVHVLYIDYGNREVLPSTRLAAL 79

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 74.26 E-value: 5.08e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  735 KLDDLNQSLADYCAQKPPNG--FKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQF 812
Cdd:cd20433    4 QLEKLMEKLRFEIASNPPLPgsYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAF 83

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 72.55 E-value: 7.25e-16

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 50355698  759 IGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAI 808
Cdd:cd20379    1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 73.87 E-value: 8.06e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  735 KLDDLNQSLADYCAQKPPNGFKAEI--GRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQF 812
Cdd:cd20412    5 QLDKLVQEMTQYYESEENRHTLLTVqvGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSDF 84

                         90
                 ....*....|
gi 50355698  813 LLLPFQGMQC 822
Cdd:cd20412   85 LSLPFQAIEC 94

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 72.72 E-value: 1.45e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  511 SGHKLAELQESLSEYCG-HVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPII 589
Cdd:cd20433    1 TGPQLEKLMEKLRFEIAsNPPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80


                 .
gi 50355698  590 P 590
Cdd:cd20433   81 P 81

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 74.82 E-value: 1.47e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  756 KAEIGRPCCAFFSGDGNWYRALVKEILpSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWT 835
Cdd:cd20438   54 KPEPGLLCCARYSKDRHYYRAVITEVL-DLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWT 132


                 ....*...
gi 50355698  836 KEATARFQ 843
Cdd:cd20438  133 KNANDFFK 140

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 71.60 E-value: 1.86e-15

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 50355698  535 FYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLL 593
Cdd:cd20410    1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 72.87 E-value: 4.40e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  717 MYSPGEFYCHFLKDDalEKLDDLNQSLADYCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGN 796
Cdd:cd20440   19 VYSPAKFYCQLDRNT--EILEALMEKIAEISKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYFVDYGN 96

                         90       100       110
                 ....*....|....*....|....*....|.
gi 50355698  797 VEEVTTDQLQAILPQF---LLLPFQGMQCWL 824
Cdd:cd20440   97 KQIVEKNEVLPIPDTAvdlLLTPMQAIKCCL 127

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 70.97 E-value: 5.84e-15

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50355698  542 VCCAQFSEDDQWYRASVL-AYASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLG 612
Cdd:cd20423    8 VCLAKYSEDGKWCRALIDnVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 72.53 E-value: 9.12e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  719 SPGEFYCHFlkddALEKLDDLNQSLADYCAQKPPNGFKA---EIGRPCCAFFSGDGNWYRALVKEIlPSGNVKVHFVDYG 795
Cdd:cd20426   10 SPEYFWCQF----ATEKIQCLAVKVQEAGEQVADRGNFIpsiYVGDPCIVKYSEDNHWYRALVTKI-NDNLVSVRFVDYG 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 50355698  796 NVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWTKEATARF 842
Cdd:cd20426   85 NEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYF 131

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 71.73 E-value: 9.41e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  979 PAYRPRTGDACCAKYTNDDFWYRAIVLE-------TSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 1051
Cdd:cd20443   34 GGFNPKKGELVLAQFSADNSWNRAMVVNaprqgtqSPKDEYEVFYIDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAH 113

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 69.08 E-value: 1.18e-14

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 50355698  539 IGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPI 588
Cdd:cd20379    1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 70.94 E-value: 1.48e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  264 VTEFKHPSNFYI-QLYSSEVLENMNQLSTSLKEtYANVVPE-DGYLPVKGEVCVAKYTVDQTWNRAIVqaVDVLQRKAHV 341
Cdd:cd20411    3 VLEVISPDLFYAlPKTGQVNVEKLKALMTELAE-YCSKQSVpQQFRPRIGDACCARFTGDKNWYRAVV--LETSDSEVKV 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 50355698  342 LYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSG 378
Cdd:cd20411   80 LYADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 71.00 E-value: 2.51e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  756 KAEIGRPCCAFFSGDGnWYRALVKEILPSGnVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNKHWT 835
Cdd:cd20422   49 KPQPGQLCCAKWKEDR-YYRAIVTAVKGKM-VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWS 126


                 ....*...
gi 50355698  836 KEATARFQ 843
Cdd:cd20422  127 PEAISAFK 134

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 70.60 E-value: 2.75e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  718 YSPGEFYCHFLKDdaLEKLDDLNQSLADYCAQKPPNGFKAEIGrpCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNV 797
Cdd:cd20439   20 NSPGDFWCQLQTK--SSELKSLMKQIQSYYLIHNDPYKHGQIA--CVAKYSKDGKWYRAAVLKQVSAKEVDVIFVDYGNQ 95

                         90       100       110
                 ....*....|....*....|....*....|
gi 50355698  798 EEVTTDQLQAILPQFLLLPFQGMQCWLVDI 827
Cdd:cd20439   96 ERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 68.66 E-value: 3.34e-14

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50355698  761 RPCCAFFSGDGNWYRALVKEI-LPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPN 831
Cdd:cd20423    7 PVCLAKYSEDGKWCRALIDNVyEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPS 78

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 69.02 E-value: 3.46e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  734 EKLDDLNQSLADYCAQKPPN-GFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQF 812
Cdd:cd20409    2 RQLAELQESLSAYCKVAPASsDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSL 81


                 .
gi 50355698  813 L 813
Cdd:cd20409   82 L 82

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 69.02 E-value: 6.96e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  719 SPGEFYCHFLKDDAL-----EKLDDLNQSlADYCAQKPPNgfkaeIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVD 793
Cdd:cd20425   11 SPSDFYVQLAQDEDElsmisEKLNASKAN-DEEVECESLQ-----LGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQFID 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 50355698  794 YGNVEEVTTDQLQAILPQFLLLPFQGMQCWL 824
Cdd:cd20425   85 YGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 69.37 E-value: 7.29e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  719 SPGEFYCHFLKDDalEKLDDLNQSLADYCAQKppngfKAEIGRPC------CAFFSGDGNWYRALVKEILPSGNVKVHFV 792
Cdd:cd20437   14 SPSKFYCQLLSWE--PELSKLTTQMTLHYESV-----SKELNPSCenfgllCAAKGKDGQWHRGFLQQLLPPSQVKVWFI 86

                         90       100       110
                 ....*....|....*....|....*....|..
gi 50355698  793 DYGNVEEVTTDQLQAILPQFLLLPFQGMQCWL 824
Cdd:cd20437   87 DYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 68.23 E-value: 1.19e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  943 SPALFYAipsEMSENQEKLCVLAAELLEHCNAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLETSESD-VKVLYADYGN 1021
Cdd:cd20441    1 SPSRFFI---QLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVLPGKsFKVEFIDYGN 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 50355698 1022 IETLPLSRVQPIPASHLELPFQIIRCSLEGP 1052
Cdd:cd20441   78 TAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 66.00 E-value: 1.23e-13

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 50355698  986 GDACCAKYTNDDFWYRAIVLETSESD-VKVLYADYGNIETLPLSRVQPI 1033
Cdd:cd20379    2 GDLCAAKYEEDGKWYRARVLEVLSNDkVEVFFVDYGNTETVPLSDLRPL 50

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 67.87 E-value: 2.27e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  495 VAHIQTPEDFFCQQLQSGHKLAELQESLSEYcGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDY 574
Cdd:cd20440   16 ITHVYSPAKFYCQLDRNTEILEALMEKIAEI-SKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYFVDY 94

                         90       100       110
                 ....*....|....*....|....*....|...
gi 50355698  575 GNFEILSLKRLCPI---IPKLLDLPMQALNCVL 604
Cdd:cd20440   95 GNKQIVEKNEVLPIpdtAVDLLLTPMQAIKCCL 127

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 65.58 E-value: 4.14e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50355698  988 ACCAKYTNDDFWYRAIVLETSES--DVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEGPMELNG 1057
Cdd:cd20423    8 VCLAKYSEDGKWCRALIDNVYEPveMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 65.19 E-value: 7.29e-13

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50355698  313 VCVAKYTVDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAG 384
Cdd:cd20423    8 VCLAKYSEDGKWCRALIDNVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 66.32 E-value: 7.51e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  938 VLEIISPALFYAIPSEmSENQEKLCVLAAELLEHCNAQKGQPAYRP-----RTGDACCAKYTNDDFWYRAIVLET-SESD 1011
Cdd:cd20419    2 VEYIESPSQFYVRFYS-KDTSEMLEDMMIEMRRCYSNEHVSERYVMpeafiQPGQVCCVRIPEDVWWYRVIIHQVlNKQE 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 50355698 1012 VKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSL 1049
Cdd:cd20419   81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 63.51 E-value: 1.55e-12

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 50355698  981 YRPRTGDACCAKYTNDDFWYRAIVLE-TSESDVKVLYADYGNIETLPLSRVQPIPASHL 1038
Cdd:cd20410    1 FKPIVGEPCCAFFSGDGNWYRAMVKEiLPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 64.74 E-value: 1.73e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  533 SDFYPtiGDVCCAQFSeDDQWYRASVLAYASEESV--LVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPS 610
Cdd:cd20418    2 TDFRP--EMPCLAEYS-DGKWYRAKLLSILEFNPVkiLVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPP 78

                         90       100
                 ....*....|....*....|...
gi 50355698  611 LGI-----------WTPEAVCVM 622
Cdd:cd20418   79 LNDseteripycpeWSMKALWAM 101

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 62.53 E-value: 2.32e-12

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 50355698  310 KGEVCVAKYTVDQTWNRAIVQAVDvLQRKAHVLYIDYGNEEMIPIDSVHPL 360
Cdd:cd20379    1 VGDLCAAKYEEDGKWYRARVLEVL-SNDKVEVFFVDYGNTETVPLSDLRPL 50

MYND finger;

Pssm-ID: 460312 Cd Length: 39 Bit Score: 62.05 E-value: 2.45e-12

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 50355698    163 CHRCGLFGS--LRCSQCKQTYYCSTACQRRDWSSHSTIC 199
Cdd:pfam01753    1 CAVCGKEALklLRCSRCKSVYYCSKECQKADWPYHKKEC 39

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 64.84 E-value: 3.14e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  261 KGTVTEFKHPSNFYIQLYSSEVleNMNQLSTSLKETYANVVPEDGYL--PVKGEVCVAKYTvDQTWNRAIVQAVDvlQRK 338
Cdd:cd20422    3 DAQVEFVKDPSEFWIRLGEHAV--PFSKLMRSMTAFYSQASKLDGVVlkPQPGQLCCAKWK-EDRYYRAIVTAVK--GKM 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 50355698  339 AHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCVAAVK 395
Cdd:cd20422   78 VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 64.45 E-value: 4.54e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  491 FC-GVVAHIQTPEDFFCQQLQSGHKLAELQESLSeycghviprsDFY------------PTIGDVCCAQFsEDDQWYRAS 557
Cdd:cd20422    1 FYdAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMT----------AFYsqaskldgvvlkPQPGQLCCAKW-KEDRYYRAI 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50355698  558 VLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEAVCVMK 623
Cdd:cd20422   70 VTA-VKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 63.63 E-value: 5.45e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  495 VAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDY 574
Cdd:cd20425    6 VSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQFIDY 85

                         90       100       110
                 ....*....|....*....|....*....|
gi 50355698  575 GNFEILSLKRLCPIIPKLLDLPMQALNCVL 604
Cdd:cd20425   86 GNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 63.22 E-value: 5.52e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  515 LAELQEslsEYCGHVIPRSDFY-PTIGDVCCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLL 593
Cdd:cd20415    5 TKKIQE---FYKEGDDGGLEILcPVQGQACVALF-EDGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFL 80

                         90
                 ....*....|....*.
gi 50355698  594 DLPMQALNCVLAGVKP 609
Cdd:cd20415   81 SLPEKARECRLAFIEP 96

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 62.31 E-value: 5.73e-12

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50355698  518 LQESLSEYC--GHVIPRSdfyPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKL 592
Cdd:cd20430    1 LSDELAEVCptAPPLFGT---PDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 63.08 E-value: 5.80e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  514 KLAELQESLSEY--CGHVIPRSDfYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPK 591
Cdd:cd20412    5 QLDKLVQEMTQYyeSEENRHTLL-TVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSD 83

                         90
                 ....*....|.
gi 50355698  592 LLDLPMQALNC 602
Cdd:cd20412   84 FLSLPFQAIEC 94

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 63.63 E-value: 6.76e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  938 VLEIISPALFYAIPSEMSENQEKLCVLAAELLEHCNAQKgqpaYRPRTGDACCAKYTNDDFWYRAIVLET-SESDVKVLY 1016
Cdd:cd20440   16 ITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNSQI----LDNCKTRLCLAKYFEDGQWYRALAHPVeSSSHLSVYF 91

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 50355698 1017 ADYGNIETLPLSRVQPIPASHLEL---PFQIIRCSL 1049
Cdd:cd20440   92 VDYGNKQIVEKNEVLPIPDTAVDLlltPMQAIKCCL 127

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 62.06 E-value: 1.71e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  501 PEDFFCQQLQSGHKLAELQESLSEYCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEIL 580
Cdd:cd20441    2 PSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTAVV 81

                         90       100
                 ....*....|....*....|....*..
gi 50355698  581 SLKRLCPIIPKLLDLPMQALNCVLAGV 607
Cdd:cd20441   82 DKSNIYTLQEKFLSLPRLSIPCSLSGV 108

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 62.88 E-value: 2.21e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  493 GVVAHIQTPEDFFCQQLQSGHKLAELQESLSEY---CG---HVIPRsdfyPTIGDVCCAQFSEDDQWYRAsVLAYASEES 566
Cdd:cd20438    9 AFVEYVLNPSNFWIRTDEYNNEFQALMKNIADIynlCGndeELLKK----PEPGLLCCARYSKDRHYYRA-VITEVLDLK 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 50355698  567 VLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEA 618
Cdd:cd20438   84 VSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTKNA 135

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 62.13 E-value: 3.83e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  260 IKGTVTEFKHPSNFYIQLYSSEV--LENMNQLSTSLKETYANVVPEdgylPVKGEVCVAKYTVDQTWNRAIVQAVDvlQR 337
Cdd:cd20426    1 IEAYATAVDSPEYFWCQFATEKIqcLAVKVQEAGEQVADRGNFIPS----IYVGDPCIVKYSEDNHWYRALVTKIN--DN 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50355698  338 KAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSEGCVAAVKALLFEQ 401
Cdd:cd20426   75 LVSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYFYEIVTED 138

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 62.11 E-value: 4.18e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  930 VNKTIAANVLEIISPALFYAIPSEMSENQEKLCVLAAELLEHCNAQKgQPAYRPRTGDACCAKYTNDDFWYRAIVLETSE 1009
Cdd:cd20438    3 VDAAYVAFVEYVLNPSNFWIRTDEYNNEFQALMKNIADIYNLCGNDE-ELLKKPEPGLLCCARYSKDRHYYRAVITEVLD 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 50355698 1010 SDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSL 1049
Cdd:cd20438   82 LKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 60.39 E-value: 4.71e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  964 LAAELLEHCNAQKGQPAYR-PRTGDACCAKYTNDDFWYRAIVLETSESD-VKVLYADYGNIETLPLSRVQPIPASHLELP 1041
Cdd:cd20412    9 LVQEMTQYYESEENRHTLLtVQVGDIVAAPFRHDGSWYRARVLGFLENGnLDLYFVDYGDSGYVPLEDLRALRSDFLSLP 88


                 ....*..
gi 50355698 1042 FQIIRCS 1048
Cdd:cd20412   89 FQAIECS 95

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 59.78 E-value: 5.52e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  284 ENMNQLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVdVLQRKAHVLYIDYGNEEMIPIDSVHPLSRG 363
Cdd:cd20409    2 RQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAY-SSEDSVLVGYIDFGNSEEVALSRLRPIPPS 80


                 .
gi 50355698  364 L 364
Cdd:cd20409   81 L 81

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 60.98 E-value: 6.58e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  485 LNVGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCGHVIP-RSDFYPtiGDVCCAQFSeDDQWYRASVLayAS 563
Cdd:cd20424    8 IKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKlELSVNP--GTLCLAKYS-DQHWYRGIII--TN 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 50355698  564 EESVLVGYVDYGNFEILSLKRLCPI---IPKLLDLPMQALNCVL 604
Cdd:cd20424   83 KNSTEVFFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKCSL 126

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 60.14 E-value: 7.01e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  719 SPGEFYCHFLKDDAL-----EKLDDLNQSLADYCAQKPpngfkaEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVD 793
Cdd:cd20441    1 SPSRFFIQLSEDEKVilqlaEELNETSEKSRENAAVKL------KVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFID 74

                         90       100       110
                 ....*....|....*....|....*....|....
gi 50355698  794 YGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDI 827
Cdd:cd20441   75 YGNTAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 59.71 E-value: 1.03e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  940 EIISPALFYAIpSEMSENQEKLCVLAAELlehcNAQKGQP-AYRPRTGDACCAKYTNDDF--WYRAIVLETSESDVKVLY 1016
Cdd:cd20431    2 EVVEVGHFWGY-RIDENSSEILQQLTAEI----NQRQLVPlTTKPVPNLLCLAPFTDADMkkYYRAKILYVSGSSAEVFF 76

                         90       100
                 ....*....|....*....|....*
gi 50355698 1017 ADYGNIETLPLSRVQPIPASHLELP 1041
Cdd:cd20431   77 VDYGNTSQVPSSLLREIPETLLTLP 101

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 60.21 E-value: 1.10e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  719 SPGEFYCHFLKDDalEKLDDLNQSLADYCAQKPPNGFKAEIGRPCCAFFSgDGNWYRALVKEILPsgNVKVHFVDYGNVE 798
Cdd:cd20424   23 DPWTFYCQLARNA--GVLDQLASAISRLSSEIRKLELSVNPGTLCLAKYS-DQHWYRGIIITNKN--STEVFFVDYGNTE 97

                         90       100       110
                 ....*....|....*....|....*....|..
gi 50355698  799 EVTTDQLqaiLP------QFLLLPFQGMQCWL 824
Cdd:cd20424   98 KVEKEDM---LPipsdayELLLLPMQAIKCSL 126

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 58.37 E-value: 1.22e-10

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50355698  758 EIGRPCCAffSGDGNWYRALVKEILPSGN-VKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQP 829
Cdd:cd20407    6 EVGVICAA--PVMNAWYRAQVVGVFEETDeVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 58.59 E-value: 2.03e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  534 DFYPTIGDVCCAQF----------SEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCV 603
Cdd:cd20427    9 EFYSKSSTAMCLRSpsvgqlvavkAEEDAWLRAQVIE-VEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCK 87


                 ....*.
gi 50355698  604 LAGVKP 609
Cdd:cd20427   88 LAGLEP 93

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 59.04 E-value: 2.77e-10

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50355698  988 ACCAKYTNDDFWYRAIVL-ETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 1051
Cdd:cd20439   60 ACVAKYSKDGKWYRAAVLkQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNN 124

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 57.60 E-value: 2.82e-10

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50355698  539 IGDVCCAQFseDDQWYRASVLAYASE-ESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 609
Cdd:cd20407    7 VGVICAAPV--MNAWYRAQVVGVFEEtDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 56.90 E-value: 2.82e-10

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 50355698     537 PTIGDVCCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKL 592
Cdd:smart00333    3 FKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 59.06 E-value: 2.87e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  941 IISPALFYAipsEMSENQEKLCVLAAELLEHCNA-QKGQPAYRPrtGDACCAKYTnDDFWYRAIVLETSESdVKVLYADY 1019
Cdd:cd20424   21 VNDPWTFYC---QLARNAGVLDQLASAISRLSSEiRKLELSVNP--GTLCLAKYS-DQHWYRGIIITNKNS-TEVFFVDY 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 50355698 1020 GNIETLPLSRVQPIPASHLE---LPFQIIRCSL 1049
Cdd:cd20424   94 GNTEKVEKEDMLPIPSDAYElllLPMQAIKCSL 126

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 56.13 E-value: 5.03e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 50355698     760 GRPCCAFFSgDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAI 808
Cdd:smart00333    6 GDKVAARWE-DGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQL 53

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 57.11 E-value: 5.40e-10

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 50355698  770 DGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGM 820
Cdd:cd20429   41 ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQLPFQAI 91

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 57.44 E-value: 5.93e-10

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50355698  976 KGQPAYRPRTGDACCAKYtNDDFWYRA-IVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSL 1049
Cdd:cd20415   18 GGLEILCPVQGQACVALF-EDGAWYRArIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRL 91

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 57.85 E-value: 6.54e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  938 VLEIISPALFYAipsEMSENQEKLCVLAAELlehcNAQKGQPAYRP----RTGDACCAKYTNDDFWYRAIVLETSESD-V 1012
Cdd:cd20425    6 VSHVNSPSDFYV---QLAQDEDELSMISEKL----NASKANDEEVEceslQLGDLICAEYPEDGLWYRAVVKEKIPNNlV 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 50355698 1013 KVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSL 1049
Cdd:cd20425   79 SVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 57.82 E-value: 8.72e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  494 VVAHIQTPEDFFCQQLQSGHKLAELQESLSE-YCGHVIPRSDFYPTIGDVCCAQFSEDDQWYRASVL-AYASEESVLVGY 571
Cdd:cd20421   16 VVTEVTDPHRIFCQLRSLSQELKRLSESMHQyYEGRVGSGYETRPEKLGSPCAARGSDGRWYRAVLQqVFSANRVVEVLH 95

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 50355698  572 VDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAG 606
Cdd:cd20421   96 VDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 57.46 E-value: 8.87e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  716 MMYSPGEFYCHFLKDDALEKLDDLNQSLADYCAQKP-------PNGFKAEiGRPCCAFFSGDGNWYRALVKEILPSGNVK 788
Cdd:cd20419    4 YIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEHvseryvmPEAFIQP-GQVCCVRIPEDVWWYRVIIHQVLNKQEVE 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 50355698  789 VHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWL 824
Cdd:cd20419   83 VFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 57.52 E-value: 1.22e-09

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50355698  982 RPRTGDACCAKYtNDDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSL 1049
Cdd:cd20422   49 KPQPGQLCCAKW-KEDRYYRAIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCL 115

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 55.92 E-value: 2.96e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  495 VAHIQTPEDF---FCQQLQSgHKLAELQESLSEYCG--HVIPRS---DFYPTIGDVCCAQFSEDDQWYRASVLAYASEES 566
Cdd:cd20419    2 VEYIESPSQFyvrFYSKDTS-EMLEDMMIEMRRCYSneHVSERYvmpEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQE 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 50355698  567 VLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVL 604
Cdd:cd20419   81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 55.89 E-value: 3.36e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  942 ISPALFYAipsEMSENQEKLCVLAAELLEHCNAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLET-SESDVKVLYADYG 1020
Cdd:cd20437   13 VSPSKFYC---QLLSWEPELSKLTTQMTLHYESVSKELNPSCENFGLLCAAKGKDGQWHRGFLQQLlPPSQVKVWFIDYG 89

                         90       100
                 ....*....|....*....|....*....
gi 50355698 1021 NIETLPLSRVQPIPASHLELPFQIIRCSL 1049
Cdd:cd20437   90 NSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 55.55 E-value: 3.96e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  725 CHFLKDDALEKLDDLNQSLADYCAQK---PPNGFKAEIGRPCCAFFSGDGNWYRALVKE------ILPSGNVKVHFVDYG 795
Cdd:cd20443    3 RFYVQVVSDQRLSSIQQQLEGLSLKDkanPPGGFNPKKGELVLAQFSADNSWNRAMVVNaprqgtQSPKDEYEVFYIDYG 82

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 50355698  796 NVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPP 830
Cdd:cd20443   83 NQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKVP 117

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 55.11 E-value: 4.81e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50355698  984 RTGDACCAKYtNDDFWYRAIVLETSE-SDVKVL--YADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 1051
Cdd:cd20418    5 RPEMPCLAEY-SDGKWYRAKLLSILEfNPVKILvrHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAG 74

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 54.36 E-value: 5.97e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  760 GRPCCAFFSgDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQP 829
Cdd:cd20415   28 GQACVALFE-DGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 53.45 E-value: 6.32e-09

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 50355698  742 SLADYCAQKPPNGFKAEIGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEV 800
Cdd:cd20430    4 ELAEVCPTAPPLFGTPDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETV 62

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 55.53 E-value: 6.93e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  719 SPGEFYCHfLKDDALEKLDDLNQSLADY--CAQKPPNGFkaeIGRPCCA---FFSGDGNWYRALVKEILPSGNVKVHFVD 793
Cdd:cd20428   11 SDGTLYCQ-VPSKGLSKLNEILDKIEYYfhSRQMTSEYF---VSLPFCGkicLARYKGKWARVEITNVHSSRALDVHFLD 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 50355698  794 YGNVEEVTTDQLQAILPQFL----LLPFQGMQCWLVDIQPPNKHWTKEA 838
Cdd:cd20428   87 TGTVASVKVSELREIPPPFLreliSIPPQALKCCLADLPLNIGMWTPDA 135

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 54.95 E-value: 9.24e-09

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50355698  764 CAFFSGDGNWYRALVKEILPSG------NVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPNK--HW 834
Cdd:cd20435   56 CAVEDENNLYHRVKVLEITEKDdktkprEVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKPVDNdtEW 134

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 53.95 E-value: 1.13e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50355698  759 IGRPCCAFFSgDGNWYRALVKEILPSGNVK--VHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQPPN 831
Cdd:cd20418    6 PEMPCLAEYS-DGKWYRAKLLSILEFNPVKilVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPL 79

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 52.28 E-value: 1.37e-08

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 50355698     308 PVKGEVCVAKYTvDQTWNRAIVQAVDVLQrKAHVLYIDYGNEEMIPIDSVHPL 360
Cdd:smart00333    3 FKVGDKVAARWE-DGEWYRARIVKVDGEQ-LYEVFFIDYGNEEVVPPSDLRQL 53

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 54.37 E-value: 1.96e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  505 FCQQLQSG-HKLAELQESLSEYCGHVIPRSDFY---PTIGDVCCAQFSedDQWYRASVLAYASEESVLVGYVDYG---NF 577
Cdd:cd20428   16 YCQVPSKGlSKLNEILDKIEYYFHSRQMTSEYFvslPFCGKICLARYK--GKWARVEITNVHSSRALDVHFLDTGtvaSV 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 50355698  578 EILSLKRLCPIIPK-LLDLPMQALNCVLAGVKPSLGIWTPEAV 619
Cdd:cd20428   94 KVSELREIPPPFLReLISIPPQALKCCLADLPLNIGMWTPDAV 136

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 51.48 E-value: 2.00e-08

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 50355698  311 GEVCVAKYTVDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPL 360
Cdd:cd21182    1 GDKCLAPYSDDGKYYEATIEEITEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 is widely expressed and localized both to the nucleus and cytoplasm, and may play general roles like regulation of RNA metabolism. It contains a Tudor domain and an RNA recognition motif (RRM). The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410503 Cd Length: 139 Bit Score: 53.97 E-value: 2.80e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  246 FSDLRSLQLkkTMEIKGT----VTE-FKHPSNFYIQLYSSEVLENMNQLSTSLketyANVVPEDGYLP----VKGEVCVA 316
Cdd:cd20432    6 FGDLSWLAS--IMKVHGEvgllVTDtFPHTPYFWAILLTEESQQNMQQLFSTL----AEVESQQPFLAkedvHRGRRCLA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 50355698  317 KYTVDQ---TWNRAIVqaVDVLQRKAHVLYIDYGNEEMIPIDSVHPLS 361
Cdd:cd20432   80 ECPLGEeggAWNRCWV--LDVVEDFAVVFFVDFGSTANIPLPSLRSLD 125

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 53.58 E-value: 2.83e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  263 TVTEFKHPSNFYIQLYSseVLENMNQLSTSLKETY-ANVVPEDGYLPVK-GEVCVAKyTVDQTWNRAIVQAVDVLQRKAH 340
Cdd:cd20421   16 VVTEVTDPHRIFCQLRS--LSQELKRLSESMHQYYeGRVGSGYETRPEKlGSPCAAR-GSDGRWYRAVLQQVFSANRVVE 92

                         90       100
                 ....*....|....*....|.
gi 50355698  341 VLYIDYGNEEMIPIDSVHPLS 361
Cdd:cd20421   93 VLHVDYGRKEVVSVSNLRYLA 113

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 52.82 E-value: 2.97e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  270 PSNFYIQLYSSE-----VLENMNQLSTSLKETYANVvpedgylPVKGEVCVAKYTVDQTWNRAIVQAVDVlQRKAHVLYI 344
Cdd:cd20441    2 PSRFFIQLSEDEkvilqLAEELNETSEKSRENAAVK-------LKVGDLVAAEYDEDLALYRAVITAVLP-GKSFKVEFI 73

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 50355698  345 DYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGV 379
Cdd:cd20441   74 DYGNTAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 53.19 E-value: 2.98e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  492 CGVVAHIQ-----TPEDFFCQQLQSGHKLAELQESLSEYCGHVIPRSDfyPTIG--DVCCAQFSEDDQWYRASVLAYASE 564
Cdd:cd20437    1 VGTTEKVKitaavSPSKFYCQLLSWEPELSKLTTQMTLHYESVSKELN--PSCEnfGLLCAAKGKDGQWHRGFLQQLLPP 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 50355698  565 ESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLA 605
Cdd:cd20437   79 SQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 54.27 E-value: 2.99e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  261 KGTVTEFKHPSNFYIQLY-SSEVLENMNQLSTSLKETYANVVPEDgylPVKGEVCVAKYTVDQTWNRAIVQAVDVLQRKA 339
Cdd:cd20442    5 KGTLLSVSKNGTFYVRLLrNSEQLTDLESLIAKEAKKCKFVPVED---IKEGLECLAKSKKNLKWYRAVVEHLYPETEKM 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 50355698  340 HVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKC 374
Cdd:cd20442   82 LVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 53.23 E-value: 3.36e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  264 VTEFKHPSNFYIQLYSSEvlENMNQLSTSLKEtYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIVQAVDVLQRkAHVLY 343
Cdd:cd20440   16 ITHVYSPAKFYCQLDRNT--EILEALMEKIAE-ISKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSH-LSVYF 91

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 50355698  344 IDYGNEEMIPIDSVHPLSR---GLDLFPPSAIKCC 375
Cdd:cd20440   92 VDYGNKQIVEKNEVLPIPDtavDLLLTPMQAIKCC 126

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 50.33 E-value: 4.69e-08

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 50355698  986 GDACCAKYTNDDFWYRAIVLE--TSESDVKVLYADYGNIETLPLSRVQPI 1033
Cdd:cd21182    1 GDKCLAPYSDDGKYYEATIEEitEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 50.28 E-value: 5.33e-08

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 50355698  986 GDACCAKYTNDDFWYRAIVLETSESD-VKVLYaDYGNIETLPLSRVQP 1032
Cdd:cd04508    1 GDRVEAKWSDDGQWYPATVVAVNDDGkYTVLF-DDGNEEEVSEDDIRP 47

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 52.04 E-value: 6.92e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  262 GTVTEFK-----HPSNFYIQLYSSEV-LENMNQLSTSLKETYAN--VVPEDGYlpvkGEVCVAKYTvDQTWNRAIVQAVd 333
Cdd:cd20437    2 GTTEKVKitaavSPSKFYCQLLSWEPeLSKLTTQMTLHYESVSKelNPSCENF----GLLCAAKGK-DGQWHRGFLQQL- 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 50355698  334 VLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVS 377
Cdd:cd20437   76 LPPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 52.64 E-value: 7.01e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50355698  537 PTIGDVCCAQfSEDDQWYRASVLAYASEES------VLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKP 609
Cdd:cd20435   50 VKVGDLCAVE-DENNLYHRVKVLEITEKDDktkpreVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKP 127

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 52.12 E-value: 9.28e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  264 VTEFKHPSNFYIQL-YSSEVLE----NMNQLSTSLKETYANVVPedgylpvkGEVCVAKYTvDQTWNRAIVQAvdvLQRK 338
Cdd:cd20424   18 ITYVNDPWTFYCQLaRNAGVLDqlasAISRLSSEIRKLELSVNP--------GTLCLAKYS-DQHWYRGIIIT---NKNS 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 50355698  339 AHVLYIDYGNEEMIPIDSVHPL---SRGLDLFPPSAIKC 374
Cdd:cd20424   86 TEVFFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKC 124

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 51.30 E-value: 1.21e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  264 VTEFKHPSNFYIQLYSSEVLENMNQLSTSLKETYAN-------VVPEDGYLPvkGEVCVAKYTVDQTWNRAIVQAVdVLQ 336
Cdd:cd20419    2 VEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNehvseryVMPEAFIQP--GQVCCVRIPEDVWWYRVIIHQV-LNK 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 50355698  337 RKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKC 374
Cdd:cd20419   79 QEVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPA 116

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 51.66 E-value: 1.30e-07

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 50355698  759 IGRPCCAFfSGDGNWYRALVKEILPSGN-VKVHFVDYGNVEEVTTDQLQAILPQFLLLP 816
Cdd:cd20421   63 LGSPCAAR-GSDGRWYRAVLQQVFSANRvVEVLHVDYGRKEVVSVSNLRYLAPEYFRMP 120

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 49.19 E-value: 1.46e-07

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 50355698     986 GDACCAKYtNDDFWYRAIVLE-TSESDVKVLYADYGNIETLPLSRVQPIP 1034
Cdd:smart00333    6 GDKVAARW-EDGEWYRARIVKvDGEQLYEVFFIDYGNEEVVPPSDLRQLP 54

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 51.71 E-value: 1.80e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  270 PSNFYIQL--YSSEVLENMNQLStslkETYANVVPEDGYL--PVKGEVCVAKYTVDQTWNRAIVqaVDVLQRKAHVLYID 345
Cdd:cd20438   17 PSNFWIRTdeYNNEFQALMKNIA----DIYNLCGNDEELLkkPEPGLLCCARYSKDRHYYRAVI--TEVLDLKVSVYFLD 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 50355698  346 YGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIPTAGEWSE 388
Cdd:cd20438   91 FGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTK 133

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 51.27 E-value: 1.86e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  927 ELPVNKTIAANVLEIISPALFYAIPSEMSENQEKLCVLAAELLEHCNAQKGQpAYRPRTGDACCAKyTNDDFWYRAIVLE 1006
Cdd:cd20421    6 QLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGSGYE-TRPEKLGSPCAAR-GSDGRWYRAVLQQ 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 50355698 1007 TSESD--VKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEG 1051
Cdd:cd20421   84 VFSANrvVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 48.84 E-value: 1.87e-07

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 50355698  759 IGRPCCAFFSGDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQ 806
Cdd:cd20399    3 VGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQLK 50

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 48.81 E-value: 1.87e-07

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 50355698  539 IGDVCCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLKRLCPIIPK 591
Cdd:cd20398    3 VGDKCRAVYSEDGIIYEATIVSiDAERGTCVVRYTGYGNEEEQNLSDLLPPSGE 56

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 51.58 E-value: 2.38e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  492 CGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEycghVIPRSDFYPTI----GDVCCAQFSEDDQWYRASVL-AYASEES 566
Cdd:cd20442    5 KGTLLSVSKNGTFYVRLLRNSEQLTDLESLIAK----EAKKCKFVPVEdikeGLECLAKSKKNLKWYRAVVEhLYPETEK 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 50355698  567 VLVGYVDYGNFEILSL---KRLCpiiPKLLDLPMQALNC 602
Cdd:cd20442   81 MLVFFVDHGITEVVSMgniKQLS---NDLLQIPRQAVLC 116

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 48.35 E-value: 2.44e-07

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 50355698  760 GRPCCAFFSGDGNWYRALVKEILPSGNVKVHFvDYGNVEEVTTDQLQ 806
Cdd:cd04508    1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDIR 46

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 49.73 E-value: 2.80e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  967 ELLEHCNAQKGQPAYRPRTGDACCAKYTNDDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIPASHLELPFQIIR 1046
Cdd:cd20427    6 EMKEFYSKSSTAMCLRSPSVGQLVAVKAEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATK 85


                 ....*
gi 50355698 1047 CSLEG 1051
Cdd:cd20427   86 CKLAG 90

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 48.02 E-value: 3.40e-07

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 50355698  540 GDVCCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLKRLCPI 588
Cdd:cd21182    1 GDKCLAPYSDDGKYYEATIEEiTEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 49.31 E-value: 4.36e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  719 SPGEFYCHFLKDDALEKLDDLN-----QSLADYCAQKPPNGFkaeigrpCCAFFS-GDGN-WYRALVKEILPSgNVKVHF 791
Cdd:cd20431    5 EVGHFWGYRIDENSSEILQQLTaeinqRQLVPLTTKPVPNLL-------CLAPFTdADMKkYYRAKILYVSGS-SAEVFF 76

                         90       100
                 ....*....|....*....|....*
gi 50355698  792 VDYGNVEEVTTDQLQAILPQFLLLP 816
Cdd:cd20431   77 VDYGNTSQVPSSLLREIPETLLTLP 101

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 47.72 E-value: 5.77e-07

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 50355698  306 YLPVKGEVCVAKYTVDQTWNRAIVQavDVLQR-KAHVLYIDYGNEEMIPIDSVHPLS 361
Cdd:cd20410    1 FKPIVGEPCCAFFSGDGNWYRAMVK--EILPGgAVKVHFVDYGNVEEVTLDKLRKIT 55

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 48.06 E-value: 6.15e-07

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50355698  289 LSTSLKET--YANVVPEDgylPVKGEVCVAKYTVDQTWNRAIVQAVDVlQRKAHVLYIDYGNEEMIPIDSVHPLS 361
Cdd:cd20430    1 LSDELAEVcpTAPPLFGT---PDPNKIYGGKFSEDNCWYRCKVKSILS-DEKCTVQYIDYGNTETVSRSSIVELP 71

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 49.38 E-value: 6.56e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  270 PSNFYIQLYSSEVLENMnqLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAIV---QAVDVLqrkaHVLYIDY 346
Cdd:cd20425   12 PSDFYVQLAQDEDELSM--ISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVkekIPNNLV----SVQFIDY 85

                         90       100
                 ....*....|....*....|....*...
gi 50355698  347 GNEEMIPIDSVHPLSRGLDLFPPSAIKC 374
Cdd:cd20425   86 GNTSVVQPSKIHRLPKELLSIPALSIHC 113

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 46.48 E-value: 9.89e-07

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 50355698  760 GRPCCAFFSGDGNWYRALVKEILPSGN-VKVHFVDYGNVEEVTTDQLQAI 808
Cdd:cd21182    1 GDKCLAPYSDDGKYYEATIEEITEESDtATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 48.15 E-value: 1.05e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  497 HIQTPEDFFCQQ--LQSGHKLAELQESLSEYCGhVIPRSDFYPTigDVCCAQFSEDDQ--WYRASVLaYASEESVLVGYV 572
Cdd:cd20431    2 EVVEVGHFWGYRidENSSEILQQLTAEINQRQL-VPLTTKPVPN--LLCLAPFTDADMkkYYRAKIL-YVSGSSAEVFFV 77

                         90       100
                 ....*....|....*....|....
gi 50355698  573 DYGNFEILSLKRLCPIIPKLLDLP 596
Cdd:cd20431   78 DYGNTSQVPSSLLREIPETLLTLP 101

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 45.76 E-value: 2.24e-06

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 50355698  308 PVKGEVCVAKYtvDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGL 364
Cdd:cd20444    1 PTPGQMVIAKF--DGNHYRAIVLRVLNPDLKILVRFVDFGNVEVMKLENLYECPEYL 55

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 47.04 E-value: 2.67e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50355698  306 YLPVKGEVCVAKYTvDQTWNRAIVQAVdVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKC 374
Cdd:cd20415   23 LCPVQGQACVALFE-DGAWYRARIIGL-PGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKAREC 89

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 47.49 E-value: 3.24e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  262 GTVTEFK-----HPSNFYIQLY--SSEVLENMNQLstslkETYANVvPEDGYLPvkGEV-CVAKYTVDQTWNRAIVQAVd 333
Cdd:cd20439    9 GSVVDVKcsyvnSPGDFWCQLQtkSSELKSLMKQI-----QSYYLI-HNDPYKH--GQIaCVAKYSKDGKWYRAAVLKQ- 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 50355698  334 VLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGV 379
Cdd:cd20439   80 VSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 45.75 E-value: 4.28e-06

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 50355698  991 AKYTNDDFWYRAIVLETSESD-VKVLYADYGNIETLPLSRVQPIP 1034
Cdd:cd20430   27 GKFSEDNCWYRCKVKSILSDEkCTVQYIDYGNTETVSRSSIVELP 71

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 47.25 E-value: 4.87e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  964 LAAELLEH-CNAQKGQPAYRPRTGDACCAKYTNDDFwYRAIVLETSESD-------VKVLYADYGNIETLPLSRVQPIPA 1035
Cdd:cd20435   30 LSMKLNMYySDPSNRILHGKVKVGDLCAVEDENNLY-HRVKVLEITEKDdktkpreVLVKFIDEGRVETVVVSQLLELPE 108

                         90
                 ....*....|
gi 50355698 1036 SHLELPFQII 1045
Cdd:cd20435  109 ELKSLPPQAV 118

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 45.28 E-value: 5.18e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50355698  988 ACCAKYTNDDfWYRAIVLETSESD--VKVLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSL 1049
Cdd:cd20407    9 VICAAPVMNA-WYRAQVVGVFEETdeVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYL 71

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 44.64 E-value: 5.26e-06

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 50355698  760 GRPCCAFFSGDGNWYRALVKEILPSGNVK-VHFVDYGNVEEVTTDQLQAI 808
Cdd:cd20413    4 GDECLAKYWEDNKFYRAEVTAVHPSGKTAvVKFMEYGNYEEVLLSDIKPI 53

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 44.73 E-value: 6.66e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50355698  986 GDACCAKYTnDDFWYRAIVLETSESDVKVLYADYGNIETLPLSRVQPIpASHLELPFQIIRCSLEG 1051
Cdd:cd20417    4 GEGCVVRGS-DTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPM-VLYPDIPQFCIPCQLYG 67

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 44.25 E-value: 8.03e-06

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 50355698  310 KGEVCVAKYTVDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPL 360
Cdd:cd20413    3 PGDECLAKYWEDNKFYRAEVTAVHPSGKTAVVKFMEYGNYEEVLLSDIKPI 53

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 46.26 E-value: 1.30e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  539 IGDVCCAQFSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQALNCVLAGVKPSLGIWTPEA 618
Cdd:cd20436   49 VGEFCLVEDTTSGEWYRGRVLE-KIDEKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTA 127


                 .
gi 50355698  619 V 619
Cdd:cd20436  128 V 128

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 43.10 E-value: 1.68e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 50355698  984 RTGDACCAKYTNDDFWYRAIV--LETSESDVKVLYADYGNIETLPLSRVQPI 1033
Cdd:cd20413    2 KPGDECLAKYWEDNKFYRAEVtaVHPSGKTAVVKFMEYGNYEEVLLSDIKPI 53

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 43.06 E-value: 1.98e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 50355698  537 PTIGDVCCAQFseDDQWYRASVL-AYASEESVLVGYVDYGNFEILSLKRL--CP 587
Cdd:cd20444    1 PTPGQMVIAKF--DGNHYRAIVLrVLNPDLKILVRFVDFGNVEVMKLENLyeCP 52

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 42.03 E-value: 4.48e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 50355698  989 CCAKYtnDDFWYRAIVLEtSESDVK--VLYADYGNIETLPLSRVQPIP 1034
Cdd:cd20445    5 CIAKY--MDKWYRAVCLE-SVGDGRptVLFCDYGNILMARLTDIRPFP 49

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 43.57 E-value: 4.53e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  770 DGNWYRALVKEIlPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQP 829
Cdd:cd20427   35 EDAWLRAQVIEV-EEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLAGLEP 93

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 41.91 E-value: 4.83e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 50355698  538 TIGDVCCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCP 587
Cdd:cd20399    2 KVGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQLKP 51

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 41.91 E-value: 4.83e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 50355698  984 RTGDACCAKYTNDDFWYRAIVLETSE-SDVKVLYADYGNIETLPLSRVQPIPAS 1036
Cdd:cd20399    2 KVGDKCMAVWSEDGQYYEATIEEISEdGTCTVTFDGYGNTEVTPLSQLKPREEG 55

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 44.72 E-value: 5.11e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  269 HPSNFYIQL---YSS------EVLENMNQLSTSLKETYANvvpedgylpvkGEVCVAKYTVDQTWNRAIVQAVDVLQRka 339
Cdd:cd20436   10 HPKEVLVKFqgqYNSiceldyHILQNEIQNATKSKSSWGV-----------GEFCLVEDTTSGEWYRGRVLEKIDEKY-- 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50355698  340 HVLYIDYGNeeMIPIDSVHPLSRGLDLF--PPSAIKCCVSGVIPTAGEWSEGCVAAVKALLFEQFC 403
Cdd:cd20436   77 EVFLIDRGE--VLNVHATNMASASGELFqlPPKAVCGIFANILPIGEKWSSTAVNYFSSLIGSQVK 140

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 40.65 E-value: 1.33e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 50355698  540 GDVCCAQFSEDDQWYRASVLAYASEESVLVGYvDYGNFEILSLKRLCP 587
Cdd:cd04508    1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDIRP 47

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 40.67 E-value: 1.60e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 50355698  758 EIGRPCCAFFSgDGNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQlqaILP 810
Cdd:cd20384    6 KEGSRCLAKYD-DGLWYPATVTDIDEDGKYTVKFDSYGEVAVVELDD---ILP 54

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 42.72 E-value: 2.63e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  936 ANVLEIISPALFYAIPSEMSENQEKLCVLAAELLEHCNAQkgqPAYRPRTGDACCAKYTNDDFWYRAIVLETSESDVK-- 1013
Cdd:cd20442    6 GTLLSVSKNGTFYVRLLRNSEQLTDLESLIAKEAKKCKFV---PVEDIKEGLECLAKSKKNLKWYRAVVEHLYPETEKml 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 50355698 1014 VLYADYGNIETLPLSRVQPIPASHLELPFQIIRCSLEGPMELNGSCSQLVMELL 1067
Cdd:cd20442   83 VFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLCRWNWPESSKELSFEILWKSL 136

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 40.02 E-value: 2.68e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 50355698  540 GDVCCAQFSEDDQWYRASVLAYASEESV-LVGYVDYGNFEILSLKRLCPI 588
Cdd:cd20413    4 GDECLAKYWEDNKFYRAEVTAVHPSGKTaVVKFMEYGNYEEVLLSDIKPI 53

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 39.95 E-value: 3.07e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 50355698  758 EIGRPCCAFFSGDGNWYRALVKEI-LPSGNVKVHFVDYGNVEEV 800
Cdd:cd20398    2 KVGDKCRAVYSEDGIIYEATIVSIdAERGTCVVRYTGYGNEEEQ 45

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 39.60 E-value: 3.26e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 50355698  770 DGNWYRALVKEIL-PSGNVKVHFVDYGNVEEVTTDQLQaILPQFL 813
Cdd:cd20444   12 DGNHYRAIVLRVLnPDLKILVRFVDFGNVEVMKLENLY-ECPEYL 55

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 38.56 E-value: 9.35e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50355698  312 EVCVAKYtvDQTWNRAI-VQAVDvlQRKAHVLYIDYGNEEMIPIDSVHPlsrgldlFPPSAIK 373
Cdd:cd20445    3 ELCIAKY--MDKWYRAVcLESVG--DGRPTVLFCDYGNILMARLTDIRP-------FPPTFAT 54

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 38.36 E-value: 9.87e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 50355698  986 GDACCAKYTnDDFWYRAIVLETSESD-VKVLYADYGNIETLPLSRVQPI 1033
Cdd:cd20384    8 GSRCLAKYD-DGLWYPATVTDIDEDGkYTVKFDSYGEVAVVELDDILPL 55

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 39.39 E-value: 1.05e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  960 KLCVLAAELLEHCNAQKGQPAyRPRTGDACCAKYTNDdfWYRAIVLET-SESDVKVLYADYGNIETLPLSRVQPIPASHL 1038
Cdd:cd20429    8 KLEVLMEEMILYYNKTEERPV-AIEKNKVYAAKIENN--WYRVLVKGIlTNGLVSVYELDYGKHELVSIRKVQPLIEKFR 84


                 ....*..
gi 50355698 1039 ELPFQII 1045
Cdd:cd20429   85 QLPFQAI 91

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 39.39 E-value: 1.12e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 50355698  542 VCCAQFseDDQWYRASVLAYASEESVLVGYVDYGNFEILSLKRLCPIIPKLLDLPMQAL 600
Cdd:cd20429   35 VYAAKI--ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQLPFQAI 91

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 38.02 E-value: 1.24e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50355698  311 GEVCVAKYTVDQTWNRAIVQAVDVLQRKAHVLYIDYGNEEmipidsVHPLSrglDLFPPSAI 372
Cdd:cd20398    4 GDKCRAVYSEDGIIYEATIVSIDAERGTCVVRYTGYGNEE------EQNLS---DLLPPSGE 56

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 37.18 E-value: 1.74e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 50355698  311 GEVCVAKYTVDQTWNRAIVQAVDvLQRKAHVLYiDYGNEEMIPIDSV 357
Cdd:cd04508    1 GDRVEAKWSDDGQWYPATVVAVN-DDGKYTVLF-DDGNEEEVSEDDI 45

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 37.80 E-value: 1.92e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  764 CAFFSGDGNWYRALVKEILpSGNVKVHFVDYGNVEEVTTDQLQAIL-----PQFlLLPFQ 818
Cdd:cd20417    7 CVVRGSDTLWYRGKVLEVI-GGMVRVQYVDQGYIEKIPQCHLYPMVlypdiPQF-CIPCQ 64

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 37.40 E-value: 2.23e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 50355698  771 GNWYRALVKEILPSGNVKVHFVDYGNVEEVTTDQLQAILPQFLLLP 816
Cdd:cd20445   11 DKWYRAVCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFATEP 56

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410505 Cd Length: 164 Bit Score: 39.71 E-value: 3.10e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  720 PGEFYCHFLK--------DDALEKL-DDLNQSLADYCAQ----KPPNgfkAEIGRPCCAFFSGDGNWYRALVKEILPSGN 786
Cdd:cd20434    9 PGCFWGRILKgsgdlvvnPEEYENLqDEMNQFYHKGYKDveeiKPST---LEEGQVCVVFCEELKCWCRAVVESLMSSAD 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50355698  787 ---VKVHFVDYGNVEEVTTDQLQAILPQFLLLPFQGMQCWLVDIQP---------------PNKHWTKEATARFQ 843
Cdd:cd20434   86 dylAECFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYGIKPvtlhvdlcedkakivPARKWDSAAIQYFQ 160

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410487 Cd Length: 82 Bit Score: 37.47 E-value: 4.55e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50355698  289 LSTSLKETYANVVPEdgylPVKGEV---CVAKYTVDQTWNRAIVQAVdVLQRKAHVLYIDYGNEEMIPIDSVHPL 360
Cdd:cd20416    1 LQEKMIAEYENSKPE----PVKWENdmhCAVQIQDKKQWRRGQIIRV-VSDTLVEVFLYDFGNKEVVNIDCLRKL 70

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 37.79 E-value: 4.64e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  288 QLSTSLKETYANVVPEDGYLPVKGEVCVAKYTVDQTWNRAivQAVDVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLF 367
Cdd:cd20427    2 QMEDEMKEFYSKSSTAMCLRSPSVGQLVAVKAEEDAWLRA--QVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSL 79

                         90
                 ....*....|....
gi 50355698  368 PPSAIKCCVSGVIP 381
Cdd:cd20427   80 PFQATKCKLAGLEP 93

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 38.39 E-value: 4.75e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  269 HPSNFYIQL-----YSSEVLENMN----QLSTSLKETYA---NVVPEDgyLPVKGEVCVAKYTvDQTWNRAIVQAV---- 332
Cdd:cd20435    1 DATHYSARIlehrsSDGEVTKSMSstylKLSMKLNMYYSdpsNRILHG--KVKVGDLCAVEDE-NNLYHRVKVLEItekd 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 50355698  333 -DVLQRKAHVLYIDYGNEEMIPIDSVHPLSRGLDLFPPSAIKCCVSGVIP 381
Cdd:cd20435   78 dKTKPREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKP 127

first Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410491 Cd Length: 132 Bit Score: 38.18 E-value: 5.51e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50355698  517 ELQES-LSEYCGHVIPRSDfyPTIGDVCCAQFseDDQWYRASVLAYASEESVlVGYVDYGNFEILSLKRLCPIIPKLLDL 595
Cdd:cd20420   44 EIQAAvKMRGCGAGDGGAE--PSVGDLCLVEV--GGLWHRCRVVSRQGDDYR-VFLLDEGRTVVARAKSLARGRKDFFSL 118

                         90
                 ....*....|....
gi 50355698  596 PMQALNCVLAGVKP 609
Cdd:cd20420  119 PPEVLGCVLANLVP 132

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 36.09 E-value: 6.25e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 50355698  986 GDACCAKYTNDDFWYRAIVLETSESDVK--VLYADYGNIETLPLSRVQPIPAS 1036
Cdd:cd20398    4 GDKCRAVYSEDGIIYEATIVSIDAERGTcvVRYTGYGNEEEQNLSDLLPPSGE 56

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 35.74 E-value: 7.32e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 50355698  983 PRTGDACCAKYtnDDFWYRAIVLETSESDVK--VLYADYGNIETLPLSRVQPIP 1034
Cdd:cd20444    1 PTPGQMVIAKF--DGNHYRAIVLRVLNPDLKilVRFVDFGNVEVMKLENLYECP 52