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Conserved domains on  [gi|50659100|ref|NP_001001991|]
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inactive serine protease PAMR1 isoform b precursor [Homo sapiens]

Protein Classification

CUB and Tryp_SPc domain-containing protein( domain architecture ID 10035774)

protein containing domains CUB, EGF_CA, CCP, and Tryp_SPc

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 461-718 2.37e-41

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


:

Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 150.89  E-value: 2.37e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 461 RWPWQAAIYRRTSGVHdgslhkgawflvCSGALVNERTVVVAAHCVTDlgkvtmIKTADLKVVLGKFYRDddRDEKTIQS 540
Cdd:cd00190  11 SFPWQVSLQYTGGRHF------------CGGSLISPRWVLTAAHCVYS------SAPSNYTVRLGSHDLS--SNEGGGQV 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 541 LQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWnvlADVRSPGFKNDTLRSG 620
Cdd:cd00190  71 IKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGY--NLPAGTTCTVSGW---GRTSEGGPLPDVLQEV 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 621 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCAsWEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDktC-SH 699
Cdd:cd00190 146 NVPIVSNAECKRAYSYGGT---ITDNMLCA-GGLEGGKDACQGDSGGPLVCNDNG------RGVLVGIVSWGSG--CaRP 213

                       250
                ....*....|....*....
gi 50659100 700 RLSTAFTKVLPFKDWIERN 718
Cdd:cd00190 214 NYPGVYTRVSSYLDWIQKT 232
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 128-234 5.97e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 122.91  E-value: 5.97e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 128 CGQVLRAPKGQILL-----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNE 202
Cdd:cd00041   1 CGGTLTASTSGTISspnypNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 50659100 203 RPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYE 234
Cdd:cd00041  81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 280-343 1.21e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.47  E-value: 1.21e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50659100 280 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICI 343
Cdd:cd00033   1 CPPPPVPENGTVTGSKGS-------YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 240-272 2.21e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 2.21e-06
                        10        20        30
                ....*....|....*....|....*....|...
gi 50659100 240 SSSPCFHDGTCVlDKAGSYKCACLAGYTGQRCE 272
Cdd:cd00054   7 SGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 408-443 1.87e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.75  E-value: 1.87e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 50659100 408 TQLQYECiSPFYRRLGSSRRTCLRTGKWSGRAPSCI 443
Cdd:cd00033  23 STVTYSC-NEGYTLVGSSTITCTENGGWSPPPPTCE 57
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 461-718 2.37e-41

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 150.89  E-value: 2.37e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 461 RWPWQAAIYRRTSGVHdgslhkgawflvCSGALVNERTVVVAAHCVTDlgkvtmIKTADLKVVLGKFYRDddRDEKTIQS 540
Cdd:cd00190  11 SFPWQVSLQYTGGRHF------------CGGSLISPRWVLTAAHCVYS------SAPSNYTVRLGSHDLS--SNEGGGQV 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 541 LQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWnvlADVRSPGFKNDTLRSG 620
Cdd:cd00190  71 IKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGY--NLPAGTTCTVSGW---GRTSEGGPLPDVLQEV 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 621 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCAsWEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDktC-SH 699
Cdd:cd00190 146 NVPIVSNAECKRAYSYGGT---ITDNMLCA-GGLEGGKDACQGDSGGPLVCNDNG------RGVLVGIVSWGSG--CaRP 213

                       250
                ....*....|....*....
gi 50659100 700 RLSTAFTKVLPFKDWIERN 718
Cdd:cd00190 214 NYPGVYTRVSSYLDWIQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 461-715 6.87e-39

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 143.59  E-value: 6.87e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100    461 RWPWQAAIYRRTsgvhdgslhkgaWFLVCSGALVNERTVVVAAHCVTDLGKvtmiktADLKVVLGKFYRDDDRDEKTIQs 540
Cdd:smart00020  12 SFPWQVSLQYGG------------GRHFCGGSLISPRWVLTAAHCVRGSDP------SNIRVRLGSHDLSSGEEGQVIK- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100    541 lqISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWNVLADvrSPGFKNDTLRSG 620
Cdd:smart00020  73 --VSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNY--NVPAGTTCTVSGWGRTSE--GAGSLPDTLQEV 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100    621 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCASWePTAPSDICTAETGGIAAVSfpgraspEPRWHLMGLVSWSYDktC-SH 699
Cdd:smart00020 147 NVPIVSNATCRRAYSGGGA---ITDNMLCAGG-LEGGKDACQGDSGGPLVCN-------DGRWVLVGIVSWGSG--CaRP 213

                          250
                   ....*....|....*.
gi 50659100    700 RLSTAFTKVLPFKDWI 715
Cdd:smart00020 214 GKPGVYTRVSSYLDWI 229
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 462-719 6.49e-36

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 136.32  E-value: 6.49e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 462 WPWQAAIYRRTsgvhdgslhkGAWFLVCSGALVNERTVVVAAHCVTDLGkvtmikTADLKVVLGkfyrDDDRDEKTIQSL 541
Cdd:COG5640  42 YPWMVALQSSN----------GPSGQFCGGTLIAPRWVLTAAHCVDGDG------PSDLRVVIG----STDLSTSGGTVV 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 542 QISAIILHPNYDPILLDADIAILKLldkARISTRVQPICLAASRDLSTSFQEshITVAGWNVLADvrSPGFKNDTLRSGV 621
Cdd:COG5640 102 KVARIVVHPDYDPATPGNDIALLKL---ATPVPGVAPAPLATSADAAAPGTP--ATVAGWGRTSE--GPGSQSGTLRKAD 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 622 VSVVDSLLCEeqhedhGIPVSVTDNMFCASwEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDkTCSHRL 701
Cdd:COG5640 175 VPVVSDATCA------AYGGFDGGTMLCAG-YPEGGKDACQGDSGGPLVVKDGG------GWVLVGVVSWGGG-PCAAGY 240

                       250
                ....*....|....*...
gi 50659100 702 STAFTKVLPFKDWIERNM 719
Cdd:COG5640 241 PGVYTRVSAYRDWIKSTA 258
Trypsin pfam00089
Trypsin;
462-715 1.20e-34

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 131.41  E-value: 1.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100   462 WPWQAAIYRRTSGvhdgslhkgawfLVCSGALVNERTVVVAAHCVTDLGkvtmiktaDLKVVLGKfyRDDDRDEKTIQSL 541
Cdd:pfam00089  12 FPWQVSLQLSSGK------------HFCGGSLISENWVLTAAHCVSGAS--------DVKVVLGA--HNIVLREGGEQKF 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100   542 QISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDLSTsfQESHITVAGW-NVLADVRSpgfknDTLRSG 620
Cdd:pfam00089  70 DVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLP--VGTTCTVSGWgNTKTLGPS-----DTLQEV 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100   621 VVSVVDSLLCEEQHedhgiPVSVTDNMFCASWEptaPSDICTAETGGIAAVSFPgraspeprwHLMGLVSWSYDktCSH- 699
Cdd:pfam00089 143 TVPVVSRETCRSAY-----GGTVTDTMICAGAG---GKDACQGDSGGPLVCSDG---------ELIGIVSWGYG--CASg 203

                         250
                  ....*....|....*.
gi 50659100   700 RLSTAFTKVLPFKDWI 715
Cdd:pfam00089 204 NYPGVYTPVSSYLDWI 219
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 128-234 5.97e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 122.91  E-value: 5.97e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 128 CGQVLRAPKGQILL-----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNE 202
Cdd:cd00041   1 CGGTLTASTSGTISspnypNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 50659100 203 RPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYE 234
Cdd:cd00041  81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
128-233 8.44e-28

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 108.15  E-value: 8.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100   128 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNER 203
Cdd:pfam00431   1 CGGVLTDSSGSISSpnypNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 50659100   204 PAPIQSIGSSLHVLFHSDGSKNFDGFHAIY 233
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 142-233 1.27e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 107.09  E-value: 1.27e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100    142 ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNERPAP-IQSIGSSLHVLFHS 220
Cdd:smart00042  10 QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSSNSLTLTFVS 89

                           90
                   ....*....|...
gi 50659100    221 DGSKNFDGFHAIY 233
Cdd:smart00042  90 DSSVQKRGFSARY 102
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 280-343 1.21e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.47  E-value: 1.21e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50659100 280 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICI 343
Cdd:cd00033   1 CPPPPVPENGTVTGSKGS-------YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 280-342 4.74e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 55.61  E-value: 4.74e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50659100    280 CSDPGGPVNGYqkITGGPGLINgrhakIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 342
Cdd:smart00032   1 CPPPPDIENGT--VTSSSGTYS-----YGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
280-342 8.76e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.12  E-value: 8.76e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50659100   280 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 342
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNE-------YNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 256-353 1.37e-06

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 50.42  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100  256 GSYKCACLAGYTGQRCENlleerncsdPGGPVNGYQKITGGPGLINGRHAKI------GTVVSFFCNNSYVLSGNEKRTC 329
Cdd:PHA02927 120 GESKSYCELGSTGSMVWN---------PEAPICESVKCQSPPSISNGRHNGYedfytdGSVVTYSCNSGYSLIGNSGVLC 190

                         90       100
                 ....*....|....*....|....*
gi 50659100  330 qQNGEWSgKQPIC-IKACREPKISD 353
Cdd:PHA02927 191 -SGGEWS-DPPTCqIVKCPHPTISN 213
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 240-272 2.21e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 2.21e-06
                        10        20        30
                ....*....|....*....|....*....|...
gi 50659100 240 SSSPCFHDGTCVlDKAGSYKCACLAGYTGQRCE 272
Cdd:cd00054   7 SGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
240-272 8.00e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 8.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 50659100    240 SSSPCFHDGTCVlDKAGSYKCACLAGYT-GQRCE 272
Cdd:smart00179   7 SGNPCQNGGTCV-NTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 239-270 8.18e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 8.18e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 50659100   239 CSSSPCFHDGTCVlDKAGSYKCACLAGYTGQR 270
Cdd:pfam00008   1 CAPNPCSNGGTCV-DTPGGYTCICPEGYTGKR 31
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 408-443 1.87e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.75  E-value: 1.87e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 50659100 408 TQLQYECiSPFYRRLGSSRRTCLRTGKWSGRAPSCI 443
Cdd:cd00033  23 STVTYSC-NEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 408-442 3.19e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.05  E-value: 3.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 50659100    408 TQLQYECISPfYRRLGSSRRTCLRTGKWSGRAPSC 442
Cdd:smart00032  23 DTVTYSCDPG-YTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
407-442 7.50e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 38.25  E-value: 7.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 50659100   407 HTQLQYECISPFYRRlGSSRRTCLRTGKWSGRAPSC 442
Cdd:pfam00084  22 GASVSYECDPGYRLV-GSPTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 461-718 2.37e-41

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 150.89  E-value: 2.37e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 461 RWPWQAAIYRRTSGVHdgslhkgawflvCSGALVNERTVVVAAHCVTDlgkvtmIKTADLKVVLGKFYRDddRDEKTIQS 540
Cdd:cd00190  11 SFPWQVSLQYTGGRHF------------CGGSLISPRWVLTAAHCVYS------SAPSNYTVRLGSHDLS--SNEGGGQV 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 541 LQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWnvlADVRSPGFKNDTLRSG 620
Cdd:cd00190  71 IKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGY--NLPAGTTCTVSGW---GRTSEGGPLPDVLQEV 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 621 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCAsWEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDktC-SH 699
Cdd:cd00190 146 NVPIVSNAECKRAYSYGGT---ITDNMLCA-GGLEGGKDACQGDSGGPLVCNDNG------RGVLVGIVSWGSG--CaRP 213

                       250
                ....*....|....*....
gi 50659100 700 RLSTAFTKVLPFKDWIERN 718
Cdd:cd00190 214 NYPGVYTRVSSYLDWIQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 461-715 6.87e-39

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 143.59  E-value: 6.87e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100    461 RWPWQAAIYRRTsgvhdgslhkgaWFLVCSGALVNERTVVVAAHCVTDLGKvtmiktADLKVVLGKFYRDDDRDEKTIQs 540
Cdd:smart00020  12 SFPWQVSLQYGG------------GRHFCGGSLISPRWVLTAAHCVRGSDP------SNIRVRLGSHDLSSGEEGQVIK- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100    541 lqISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWNVLADvrSPGFKNDTLRSG 620
Cdd:smart00020  73 --VSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNY--NVPAGTTCTVSGWGRTSE--GAGSLPDTLQEV 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100    621 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCASWePTAPSDICTAETGGIAAVSfpgraspEPRWHLMGLVSWSYDktC-SH 699
Cdd:smart00020 147 NVPIVSNATCRRAYSGGGA---ITDNMLCAGG-LEGGKDACQGDSGGPLVCN-------DGRWVLVGIVSWGSG--CaRP 213

                          250
                   ....*....|....*.
gi 50659100    700 RLSTAFTKVLPFKDWI 715
Cdd:smart00020 214 GKPGVYTRVSSYLDWI 229
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 462-719 6.49e-36

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 136.32  E-value: 6.49e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 462 WPWQAAIYRRTsgvhdgslhkGAWFLVCSGALVNERTVVVAAHCVTDLGkvtmikTADLKVVLGkfyrDDDRDEKTIQSL 541
Cdd:COG5640  42 YPWMVALQSSN----------GPSGQFCGGTLIAPRWVLTAAHCVDGDG------PSDLRVVIG----STDLSTSGGTVV 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 542 QISAIILHPNYDPILLDADIAILKLldkARISTRVQPICLAASRDLSTSFQEshITVAGWNVLADvrSPGFKNDTLRSGV 621
Cdd:COG5640 102 KVARIVVHPDYDPATPGNDIALLKL---ATPVPGVAPAPLATSADAAAPGTP--ATVAGWGRTSE--GPGSQSGTLRKAD 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 622 VSVVDSLLCEeqhedhGIPVSVTDNMFCASwEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDkTCSHRL 701
Cdd:COG5640 175 VPVVSDATCA------AYGGFDGGTMLCAG-YPEGGKDACQGDSGGPLVVKDGG------GWVLVGVVSWGGG-PCAAGY 240

                       250
                ....*....|....*...
gi 50659100 702 STAFTKVLPFKDWIERNM 719
Cdd:COG5640 241 PGVYTRVSAYRDWIKSTA 258
Trypsin pfam00089
Trypsin;
462-715 1.20e-34

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 131.41  E-value: 1.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100   462 WPWQAAIYRRTSGvhdgslhkgawfLVCSGALVNERTVVVAAHCVTDLGkvtmiktaDLKVVLGKfyRDDDRDEKTIQSL 541
Cdd:pfam00089  12 FPWQVSLQLSSGK------------HFCGGSLISENWVLTAAHCVSGAS--------DVKVVLGA--HNIVLREGGEQKF 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100   542 QISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDLSTsfQESHITVAGW-NVLADVRSpgfknDTLRSG 620
Cdd:pfam00089  70 DVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLP--VGTTCTVSGWgNTKTLGPS-----DTLQEV 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100   621 VVSVVDSLLCEEQHedhgiPVSVTDNMFCASWEptaPSDICTAETGGIAAVSFPgraspeprwHLMGLVSWSYDktCSH- 699
Cdd:pfam00089 143 TVPVVSRETCRSAY-----GGTVTDTMICAGAG---GKDACQGDSGGPLVCSDG---------ELIGIVSWGYG--CASg 203

                         250
                  ....*....|....*.
gi 50659100   700 RLSTAFTKVLPFKDWI 715
Cdd:pfam00089 204 NYPGVYTPVSSYLDWI 219
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 128-234 5.97e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 122.91  E-value: 5.97e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 128 CGQVLRAPKGQILL-----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNE 202
Cdd:cd00041   1 CGGTLTASTSGTISspnypNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 50659100 203 RPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYE 234
Cdd:cd00041  81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
128-233 8.44e-28

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 108.15  E-value: 8.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100   128 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNER 203
Cdd:pfam00431   1 CGGVLTDSSGSISSpnypNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 50659100   204 PAPIQSIGSSLHVLFHSDGSKNFDGFHAIY 233
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 142-233 1.27e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 107.09  E-value: 1.27e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100    142 ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNERPAP-IQSIGSSLHVLFHS 220
Cdd:smart00042  10 QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSSNSLTLTFVS 89

                           90
                   ....*....|...
gi 50659100    221 DGSKNFDGFHAIY 233
Cdd:smart00042  90 DSSVQKRGFSARY 102
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 280-343 1.21e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.47  E-value: 1.21e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50659100 280 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICI 343
Cdd:cd00033   1 CPPPPVPENGTVTGSKGS-------YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 280-342 4.74e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 55.61  E-value: 4.74e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50659100    280 CSDPGGPVNGYqkITGGPGLINgrhakIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 342
Cdd:smart00032   1 CPPPPDIENGT--VTSSSGTYS-----YGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
280-342 8.76e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.12  E-value: 8.76e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50659100   280 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 342
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNE-------YNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 256-353 1.37e-06

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 50.42  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100  256 GSYKCACLAGYTGQRCENlleerncsdPGGPVNGYQKITGGPGLINGRHAKI------GTVVSFFCNNSYVLSGNEKRTC 329
Cdd:PHA02927 120 GESKSYCELGSTGSMVWN---------PEAPICESVKCQSPPSISNGRHNGYedfytdGSVVTYSCNSGYSLIGNSGVLC 190

                         90       100
                 ....*....|....*....|....*
gi 50659100  330 qQNGEWSgKQPIC-IKACREPKISD 353
Cdd:PHA02927 191 -SGGEWS-DPPTCqIVKCPHPTISN 213
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 240-272 2.21e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 2.21e-06
                        10        20        30
                ....*....|....*....|....*....|...
gi 50659100 240 SSSPCFHDGTCVlDKAGSYKCACLAGYTGQRCE 272
Cdd:cd00054   7 SGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 488-600 1.10e-05

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 46.59  E-value: 1.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100 488 VCSGALVNERTVVVAAHCVTDLGKVTmiKTADLKVVLGkfYRDDDRdektiQSLQISAIILHPNYDP-ILLDADIAILKL 566
Cdd:COG3591  13 VCTGTLIGPNLVLTAGHCVYDGAGGG--WATNIVFVPG--YNGGPY-----GTATATRFRVPPGWVAsGDAGYDYALLRL 83

                        90       100       110
                ....*....|....*....|....*....|....
gi 50659100 567 ldKARISTRVQPICLAASRDLSTsfqESHITVAG 600
Cdd:COG3591  84 --DEPLGDTTGWLGLAFNDAPLA---GEPVTIIG 112
EGF_CA smart00179
Calcium-binding EGF-like domain;
240-272 8.00e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 8.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 50659100    240 SSSPCFHDGTCVlDKAGSYKCACLAGYT-GQRCE 272
Cdd:smart00179   7 SGNPCQNGGTCV-NTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 239-270 8.18e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 8.18e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 50659100   239 CSSSPCFHDGTCVlDKAGSYKCACLAGYTGQR 270
Cdd:pfam00008   1 CAPNPCSNGGTCV-DTPGGYTCICPEGYTGKR 31
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 408-443 1.87e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.75  E-value: 1.87e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 50659100 408 TQLQYECiSPFYRRLGSSRRTCLRTGKWSGRAPSCI 443
Cdd:cd00033  23 STVTYSC-NEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 408-442 3.19e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.05  E-value: 3.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 50659100    408 TQLQYECISPfYRRLGSSRRTCLRTGKWSGRAPSC 442
Cdd:smart00032  23 DTVTYSCDPG-YTLIGSSTITCLENGTWSPPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 278-353 4.22e-04

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 43.11  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50659100  278 RNCSDPGGPVNGyqkitggpGLINGRHA-KIGTVVSFFCNN----SYVLSGNEKRTCQQNGEWSGKQPIC-IKACREPKI 351
Cdd:PHA02639  83 KECNDPPSIING--------KIYNKREMyKVGDEIYYVCNEhkgvQYSLVGNEKITCIQDKSWKPDPPICkMINCRFPAL 154


                 ..
gi 50659100  352 SD 353
Cdd:PHA02639 155 QN 156
Sushi pfam00084
Sushi repeat (SCR repeat);
407-442 7.50e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 38.25  E-value: 7.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 50659100   407 HTQLQYECISPFYRRlGSSRRTCLRTGKWSGRAPSC 442
Cdd:pfam00084  22 GASVSYECDPGYRLV-GSPTITCQEDGTWSPPFPEC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 306-349 9.52e-04

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 41.96  E-value: 9.52e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 50659100  306 KIGTVVSFFCNNSYVLSGNEKRTC---QQNGEWSGKQPIC-IKACREP 349
Cdd:PHA02639  41 EIGKLIEYTCNTDYALIGDRFRTCikdKNNAIWSNKAPFCmLKECNDP 88
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 240-272 1.35e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 1.35e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 50659100 240 SSSPCFHDGTCVlDKAGSYKCACLAGYTGQ-RCE 272
Cdd:cd00053   4 ASNPCSNGGTCV-NTPGSYRCVCPPGYTGDrSCE 36
PHA02817 PHA02817
EEV Host range protein; Provisional
 307-353 3.05e-03

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 39.92  E-value: 3.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 50659100  307 IGTVVSFFCNNS-----YVLSGNEKRTCQQNGEWSGKQPIC-IKACREPKISD 353
Cdd:PHA02817  44 IGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCkIIRCRFPALQN 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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