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Conserved domains on  [gi|49457857|ref|NP_001001880|]
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myelin protein zero-like protein 1 isoform b precursor [Mus musculus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 38-154 1.16e-63

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05715:

Pssm-ID: 472250  Cd Length: 117  Bit Score: 193.03  E-value: 1.16e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857  38 LEVHTPKEIFVVNGTQGKLTCTFDSPNTTGWLTTVSWSFQPDGTDSAVSFFHYSQGQVYIGDYPPFKDRVTWAGDLDKKD 117
Cdd:cd05715   1 MEVYTPRELNVLNGSDVRLTCTFTSCYTVGDAFSVTWTYQPEGGNTTESMFHYSKGKPYILKVGRFKDRVSWAGNPSKKD 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 49457857 118 ASINIENIQAVHNGTYICDVKNPPDIVVRPGHIRLHV 154
Cdd:cd05715  81 ASIVISNLQFSDNGTYTCDVKNPPDIVGGHGEIRLYV 117
 
Name Accession Description Interval E-value
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 38-154 1.16e-63

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 193.03  E-value: 1.16e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857  38 LEVHTPKEIFVVNGTQGKLTCTFDSPNTTGWLTTVSWSFQPDGTDSAVSFFHYSQGQVYIGDYPPFKDRVTWAGDLDKKD 117
Cdd:cd05715   1 MEVYTPRELNVLNGSDVRLTCTFTSCYTVGDAFSVTWTYQPEGGNTTESMFHYSKGKPYILKVGRFKDRVSWAGNPSKKD 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 49457857 118 ASINIENIQAVHNGTYICDVKNPPDIVVRPGHIRLHV 154
Cdd:cd05715  81 ASIVISNLQFSDNGTYTCDVKNPPDIVGGHGEIRLYV 117
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 42-155 1.81e-23

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 90.21  E-value: 1.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857    42 TPKEIFVVNGTQGKLTCTFdSPNTTGWLTTVSWSFQPDGTDSAVSFFHYSQGQvyigDYPPFKDRVTWAGDLDKKDASIN 121
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTY-SSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGS----EEGVKKGRFSGRGDPSNGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 49457857   122 IENIQAVHNGTYICDVkNPPDIVVRPGHIRLHVV 155
Cdd:pfam07686  77 IQNLTLSDSGTYTCAV-IPSGEGVFGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
55-137 1.86e-12

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 60.47  E-value: 1.86e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857     55 KLTCTFdSPNTTGwLTTVSWSFQPDGtdSAVSFFHY--SQGQVYIGdyPPFKDRVTWAGDLDKKDASINIENIQAVHNGT 132
Cdd:smart00406   3 TLSCKF-SGSTFS-SYYVSWVRQPPG--KGLEWLGYigSNGSSYYQ--ESYKGRFTISKDTSKNDVSLTISNLRVEDTGT 76


                   ....*
gi 49457857    133 YICDV 137
Cdd:smart00406  77 YYCAV 81
 
Name Accession Description Interval E-value
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 38-154 1.16e-63

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 193.03  E-value: 1.16e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857  38 LEVHTPKEIFVVNGTQGKLTCTFDSPNTTGWLTTVSWSFQPDGTDSAVSFFHYSQGQVYIGDYPPFKDRVTWAGDLDKKD 117
Cdd:cd05715   1 MEVYTPRELNVLNGSDVRLTCTFTSCYTVGDAFSVTWTYQPEGGNTTESMFHYSKGKPYILKVGRFKDRVSWAGNPSKKD 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 49457857 118 ASINIENIQAVHNGTYICDVKNPPDIVVRPGHIRLHV 154
Cdd:cd05715  81 ASIVISNLQFSDNGTYTCDVKNPPDIVGGHGEIRLYV 117
IgV_EVA1 cd05880
Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are ...
 38-154 2.45e-35

Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are composed of the immunoglobulin (Ig) domain of epithelial V-like antigen 1 (EVA 1). EVA is also known as myelin protein zero-like 2. EVA is an adhesion molecule and may play a role in the structural organization of the thymus and early lymphocyte development.


Pssm-ID: 409464  Cd Length: 116  Bit Score: 120.70  E-value: 2.45e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857  38 LEVHTPKEIFVVNGTQGKLTCTFDSPNTTGWLTTVSWSFQPDGTDSAVSFFHYSQGQvyigdYPP----FKDRVTWAGDL 113
Cdd:cd05880   1 IEVYTSKEVEAVNGTDVRLKCTFSSSAPIGDTLVITWNFRPLDGGREESVFYYHKRP-----YPPpdgrFKGRVVWDGNI 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 49457857 114 DKKDASINIENIQAVHNGTYICDVKNPPDIVVRPGHIRLHV 154
Cdd:cd05880  76 MRRDASILIWQLQPTDNGTYTCQVKNPPDVHGPIGEIRLRV 116
IgV_P0 cd05879
Immunoglobulin (Ig)-like domain of protein zero (P0); The members here are composed of the ...
 38-154 1.32e-34

Immunoglobulin (Ig)-like domain of protein zero (P0); The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin.


Pssm-ID: 409463  Cd Length: 117  Bit Score: 118.83  E-value: 1.32e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857  38 LEVHTPKEIFVVNGTQGKLTCTFDSPNTTGWLTTVSWSFQPDGTDSAVSFFHYSQGQVYIGDYPPFKDRVTWAGDLDKKD 117
Cdd:cd05879   1 IVVYTDREVYGTVGSDVTLSCSFWSSEWISDDISFTWHYQPDGSRDAISIFHYGKGQPYIDNVGPFKERIEWVGNPSRKD 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 49457857 118 ASINIENIQAVHNGTYICDVKNPPDIVVRPGHIRLHV 154
Cdd:cd05879  81 GSIVIHNLDYTDNGTFTCDVKNPPDIVGKSSQVTLYV 117
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 42-155 1.81e-23

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 90.21  E-value: 1.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857    42 TPKEIFVVNGTQGKLTCTFdSPNTTGWLTTVSWSFQPDGTDSAVSFFHYSQGQvyigDYPPFKDRVTWAGDLDKKDASIN 121
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTY-SSSMSEASTSVYWYRQPPGKGPTFLIAYYSNGS----EEGVKKGRFSGRGDPSNGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 49457857   122 IENIQAVHNGTYICDVkNPPDIVVRPGHIRLHVV 155
Cdd:pfam07686  77 IQNLTLSDSGTYTCAV-IPSGEGVFGKGTRLTVL 109
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 45-152 3.79e-14

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 65.94  E-value: 3.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857  45 EIFVVNGTQGKLTCTFD-SPNTTGWLTtVSWSFQP-DGTDSAVsfFHYSQGQVYIGDYPPFKDRVTWAGDLDKKDASINI 122
Cdd:cd20960   9 EIKKVAGENVTLPCHHQlGLEDQGTLD-IEWLLLPsDKVEKVV--ITYSGDRVYNHYYPALKGRVAFTSNDLSGDASLNI 85

                        90       100       110
                ....*....|....*....|....*....|
gi 49457857 123 ENIQAVHNGTYICDVKNPPDIVVRpgHIRL 152
Cdd:cd20960  86 SNLKLSDTGTYQCKVKKAPGYAWS--KITL 113
IGv smart00406
Immunoglobulin V-Type;
55-137 1.86e-12

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 60.47  E-value: 1.86e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857     55 KLTCTFdSPNTTGwLTTVSWSFQPDGtdSAVSFFHY--SQGQVYIGdyPPFKDRVTWAGDLDKKDASINIENIQAVHNGT 132
Cdd:smart00406   3 TLSCKF-SGSTFS-SYYVSWVRQPPG--KGLEWLGYigSNGSSYYQ--ESYKGRFTISKDTSKNDVSLTISNLRVEDTGT 76


                   ....*
gi 49457857    133 YICDV 137
Cdd:smart00406  77 YYCAV 81
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 39-137 4.26e-07

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 47.06  E-value: 4.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857  39 EVHTPKEIFVVNGTQGKLTCTFDSPNTTgWLTTVSWSFQPDGTDSAVSFFHYSQGQVYIGdypPFKDRVTW-AGDLDKKD 117
Cdd:cd05718   2 RVQVPTEVTGFLGGSVTLPCSLTSPGTT-KITQVTWMKIGAGSSQNVAVFHPQYGPSVPN---PYAERVEFlAARLGLRN 77

                        90       100
                ....*....|....*....|
gi 49457857 118 ASINIENIQAVHNGTYICDV 137
Cdd:cd05718  78 ATLRIRNLRVEDEGNYICEF 97
IgV_1_Nectin-1_like cd05886
First immunoglobulin variable (IgV) domain of nectin-1, and similar domains; The members here ...
 51-141 2.61e-06

First immunoglobulin variable (IgV) domain of nectin-1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1 (PVRL1) or cluster of differentiation (CD) 111). Nectin-1 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. In addition nectins heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls), nectin-1 for example, has been shown to trans-interact with Necl-1. Nectins also interact with various other proteins, including the actin filament (F-actin)-binding protein, afadin. Mutation in the human nectin-1 gene is associated with cleft lip/palate ectodermal dysplasia syndrome (CLPED1). Nectin-1 is a major receptor for herpes simplex virus through interaction with the viral envelope glycoprotein D.


Pssm-ID: 409469  Cd Length: 113  Bit Score: 44.96  E-value: 2.61e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857  51 GTQGKLTCTFDSPNTTGWLTTVSWSFQPDGTDSAVSFFHYSQGqvyIGDYPPFKDRVTWA-GDLdkKDASINIENIQAVH 129
Cdd:cd05886  14 GTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMG---VSVLPPYRERVTFLnPSF--TDGTIRLSRLELED 88

                        90
                ....*....|..
gi 49457857 130 NGTYICDVKNPP 141
Cdd:cd05886  89 EGVYICEFATFP 100
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 51-139 1.34e-03

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 37.19  E-value: 1.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857  51 GTQGKLTCTFdSPNTTGWLTTVSWsfQPDGTDSAVSFFHYSQGQVYIGDyPPFKDRVT-WAGDLDKKDASINIENIQAVH 129
Cdd:cd20984  12 GEDGILSCTF-TPDIKLSDIVIQW--LKEGDSGLVHEFKEGKDELSRQS-PMFRGRTSlFADQVHVGNASLRLKNVQLTD 87

                        90
                ....*....|
gi 49457857 130 NGTYICDVKN 139
Cdd:cd20984  88 AGTYLCIISN 97
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 43-154 1.63e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.33  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49457857     43 PKEIFVVNGTQGKLTCTFDSPNTTgwltTVSWSFQPdgtdsavsffhysqgqvyiGDYPPFKDRVTWagDLDKKDASINI 122
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPP----EVTWYKQG-------------------GKLLAESGRFSV--SRSGSTSTLTI 55

                           90       100       110
                   ....*....|....*....|....*....|..
gi 49457857    123 ENIQAVHNGTYICDVKNPPDIVVrpGHIRLHV 154
Cdd:smart00410  56 SNVTPEDSGTYTCAATNSSGSAS--SGTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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