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Conserved domains on  [gi|134244285|ref|NP_000426|]
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neurogenic locus notch homolog protein 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1818-2043 8.43e-41

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.57  E-value: 8.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1818 ASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRsT 1897
Cdd:COG0666    33 LLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-A 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1898 DLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLF 1977
Cdd:COG0666   112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134244285 1978 LAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLGPLL 2043
Cdd:COG0666   192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALL 257
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1618-1709 8.37e-38

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


:

Pssm-ID: 411987  Cd Length: 90  Bit Score: 137.19  E-value: 8.37e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1618 ERLDFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKDVAsgHKGRREPV 1697
Cdd:cd21704     1 ERLEFPYPIKEVRGEKLEPPPPPVRLLPLLGVAAVILLVILVLGVLVARRKREHSTLWFPEGFFLKKESS--NKNRREPV 78

                          90
                  ....*....|..
gi 134244285 1698 GQDALGMKNMAK 1709
Cdd:cd21704    79 GQDALGMKHIAK 90
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1505-1560 3.13e-22

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 91.81  E-value: 3.13e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 134244285  1505 PALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHR 1560
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1577-1637 4.08e-22

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


:

Pssm-ID: 462229  Cd Length: 59  Bit Score: 91.56  E-value: 4.08e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134244285  1577 VIGSVVMLEIDNRLCLQSPenDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPP 1637
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 158-195 1.26e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 58.03  E-value: 1.26e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  158 DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE 195
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1384-1418 1.35e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.14  E-value: 1.35e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 134244285  1384 EPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCS 1418
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1425-1458 1.99e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 1.99e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 134244285  1425 WRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1458
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDC 34
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1474-1500 2.33e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 2.33e-08
                           10        20
                   ....*....|....*....|....*..
gi 134244285  1474 YCADHFADGRCDQGCNTEECGWDGLDC 1500
Cdd:pfam00066    8 YCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-846 3.11e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 3.11e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  810 DVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSC 846
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 2045-2318 4.17e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 4.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2045 PPGAFLPGLKAAQSGSKKSRRPPGKaglgPQGPRGRGKKLTLACPGPLADSSV-TLSPVDSLD-SPRPFGGPPASPGGfP 2122
Cdd:PHA03247 2680 PQRPRRRAARPTVGSLTSLADPPPP----PPTPEPAPHALVSATPLPPGPAAArQASPALPAApAPPAVPAGPATPGG-P 2754

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2123 LEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLA------PGPQLL 2196
Cdd:PHA03247 2755 ARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAspagplPPPTSA 2834

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2197 NPGTPVSPQERPPPYLA-----VPG-----HGEEYPAAGAHSSPPKARFLRVPSehPYLTPSPESpehwaSPSPPSlsdw 2266
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPlggsvAPGgdvrrRPPSRSPAAKPAAPARPPVRRLAR--PAVSRSTES-----FALPPD---- 2903

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 134244285 2267 sESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQ 2318
Cdd:PHA03247 2904 -QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGE 2954
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 469-505 8.37e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 8.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  469 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFSGSTCQ 505
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 391-429 1.76e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.76e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 134244285  391 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 429
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 849-884 2.39e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.39e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  849 DINDCD-PNPCLNGGSCQDGVGSFSCSCLPGFAGPRC 884
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 431-467 8.05e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  431 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFTGTYCE 467
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1171-1203 9.79e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 9.79e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 134244285 1171 DSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE 1203
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 274-311 1.45e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.45e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  274 DVDECQlQPNACHNGGTCFNTLGGHSCVCVNGWTGESC 311
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 507-542 1.96e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  507 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFEGTLC 542
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 929-960 2.39e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.39e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 134244285  929 SPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ 960
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 887-922 4.70e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 4.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  887 DVDECLS-NPCGP-GTCTDHVASFTCTCPPGYGGFHCE 922
Cdd:cd00054     1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1122-1158 6.50e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 6.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285 1122 DVDECASQ-PCQHGGSCIDLVARYLCSCPPGTLGVLCE 1158
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 236-272 1.51e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.51e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  236 NVDDC-PGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 272
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 545-580 4.28e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 4.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  545 NVDDC-SPDPC-HHGRCVDGIASFSCACAPGYTGTRCE 580
Cdd:cd00054     1 DIDECaSGNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1085-1120 6.21e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 6.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285 1085 VDPCL-AQPCQHGGTCRGYMGGYMCECLPGYNGDNCE 1120
Cdd:cd00054     2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 583-618 7.64e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 7.64e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  583 VDECRSQ-PCRHGGKCLDLVDKYLCRCPSGTTGVNCE 618
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
657-686 9.26e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 9.26e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 134244285    657 EINECAS-SPCGEGGSCVDGENGFRCLCPPG 686
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 620-654 3.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  620 NIDDCAS-NPCTF-GVCRDGINRYDCVCQPGFTGPLC 654
Cdd:cd00054     1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 314-349 3.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  314 NIDDCATA-VCFHGATCHDRVASFYCACPMGKTGLLC 349
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1818-2043 8.43e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.57  E-value: 8.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1818 ASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRsT 1897
Cdd:COG0666    33 LLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-A 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1898 DLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLF 1977
Cdd:COG0666   112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134244285 1978 LAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLGPLL 2043
Cdd:COG0666   192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALL 257
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1618-1709 8.37e-38

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 137.19  E-value: 8.37e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1618 ERLDFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKDVAsgHKGRREPV 1697
Cdd:cd21704     1 ERLEFPYPIKEVRGEKLEPPPPPVRLLPLLGVAAVILLVILVLGVLVARRKREHSTLWFPEGFFLKKESS--NKNRREPV 78

                          90
                  ....*....|..
gi 134244285 1698 GQDALGMKNMAK 1709
Cdd:cd21704    79 GQDALGMKHIAK 90
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1505-1560 3.13e-22

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 91.81  E-value: 3.13e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 134244285  1505 PALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHR 1560
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1577-1637 4.08e-22

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 91.56  E-value: 4.08e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134244285  1577 VIGSVVMLEIDNRLCLQSPenDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPP 1637
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1910-2002 4.74e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 78.23  E-value: 4.74e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285  1910 LILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNgANKDMQDSKeETPLFLAAREGSYEAAK 1989
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 134244285  1990 LLLDHFANREITD 2002
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1779-1992 2.17e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 84.69  E-value: 2.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1779 GMDVNVRGPDGFTPL--MLASFCggalepmpteedeaddTSASIISDLICQGAQLGARtDRTGETALH--LAARYARADA 1854
Cdd:PHA03095  107 GADVNAKDKVGRTPLhvYLSGFN----------------INPKVIRLLLRKGADVNAL-DLYGMTPLAvlLKSRNANVEL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1855 AKRLLDAGADTNAQDHSGRTPLHT-AVTADA-QGVFQILIRnRSTDLDARMADGSTALILAARLAV--EGMVEELIASHA 1930
Cdd:PHA03095  170 LRLLIDAGADVYAVDDRFRSLLHHhLQSFKPrARIVRELIR-AGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGI 248

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134244285 1931 DVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLL 1992
Cdd:PHA03095  249 SINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 158-195 1.26e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 58.03  E-value: 1.26e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  158 DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE 195
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
158-195 9.24e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 55.72  E-value: 9.24e-10
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    158 DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYT-GPLCE 195
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1384-1418 1.35e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.14  E-value: 1.35e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 134244285  1384 EPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCS 1418
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1425-1458 1.99e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 1.99e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 134244285  1425 WRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1458
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDC 34
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1421-1458 2.14e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.94  E-value: 2.14e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134244285   1421 VGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1458
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1474-1500 2.33e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 2.33e-08
                           10        20
                   ....*....|....*....|....*..
gi 134244285  1474 YCADHFADGRCDQGCNTEECGWDGLDC 1500
Cdd:pfam00066    8 YCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-846 3.11e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 3.11e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  810 DVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSC 846
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1380-1417 4.04e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.17  E-value: 4.04e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134244285   1380 EVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDC 1417
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2045-2318 4.17e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 4.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2045 PPGAFLPGLKAAQSGSKKSRRPPGKaglgPQGPRGRGKKLTLACPGPLADSSV-TLSPVDSLD-SPRPFGGPPASPGGfP 2122
Cdd:PHA03247 2680 PQRPRRRAARPTVGSLTSLADPPPP----PPTPEPAPHALVSATPLPPGPAAArQASPALPAApAPPAVPAGPATPGG-P 2754

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2123 LEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLA------PGPQLL 2196
Cdd:PHA03247 2755 ARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAspagplPPPTSA 2834

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2197 NPGTPVSPQERPPPYLA-----VPG-----HGEEYPAAGAHSSPPKARFLRVPSehPYLTPSPESpehwaSPSPPSlsdw 2266
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPlggsvAPGgdvrrRPPSRSPAAKPAAPARPPVRRLAR--PAVSRSTES-----FALPPD---- 2903

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 134244285 2267 sESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQ 2318
Cdd:PHA03247 2904 -QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGE 2954
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 469-505 8.37e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 8.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  469 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFSGSTCQ 505
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 391-429 1.76e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.76e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 134244285  391 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 429
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 849-884 2.39e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.39e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  849 DINDCD-PNPCLNGGSCQDGVGSFSCSCLPGFAGPRC 884
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1473-1500 5.48e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 47.71  E-value: 5.48e-07
                            10        20
                    ....*....|....*....|....*...
gi 134244285   1473 KYCADHFADGRCDQGCNTEECGWDGLDC 1500
Cdd:smart00004   11 AQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 431-467 8.05e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  431 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFTGTYCE 467
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
391-429 9.37e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 9.37e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 134244285    391 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYT-GPRCE 429
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
810-847 9.75e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 9.75e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    810 DVDECAGPAPCGPHGICTNLAGSFSCTCHGGYT-GPSCD 847
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1171-1203 9.79e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 9.79e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 134244285 1171 DSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE 1203
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
469-505 1.39e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.39e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    469 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFS-GSTCQ 505
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 274-311 1.45e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.45e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  274 DVDECQlQPNACHNGGTCFNTLGGHSCVCVNGWTGESC 311
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 507-542 1.96e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  507 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFEGTLC 542
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 929-960 2.39e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.39e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 134244285  929 SPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ 960
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
431-467 4.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.41e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    431 DVNECLS-GPCRNQATCLDRIGQFTCICMAGFT-GTYCE 467
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 887-922 4.70e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 4.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  887 DVDECLS-NPCGP-GTCTDHVASFTCTCPPGYGGFHCE 922
Cdd:cd00054     1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
849-884 5.11e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 5.11e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134244285    849 DINDC-DPNPCLNGGSCQDGVGSFSCSCLPGF-AGPRC 884
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1122-1158 6.50e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 6.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285 1122 DVDECASQ-PCQHGGSCIDLVARYLCSCPPGTLGVLCE 1158
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2188-2318 1.21e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.92  E-value: 1.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285  2188 PLAPGPQLLNPGTPVSPQERPPPYL-AVPGHGE----EYPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPS 2262
Cdd:pfam03154  179 GAASPPSPPPPGTTQAATAGPTPSApSVPPQGSpatsQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPP 258

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 134244285  2263 LSDWSESTPSPATATG--------AMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQ 2318
Cdd:pfam03154  259 SQVSPQPLPQPSLHGQmppmphslQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQ 322
EGF_CA smart00179
Calcium-binding EGF-like domain;
1122-1158 1.39e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.39e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285   1122 DVDECAS-QPCQHGGSCIDLVARYLCSCPPG-TLGVLCE 1158
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 236-272 1.51e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.51e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  236 NVDDC-PGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 272
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
507-543 1.76e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.76e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    507 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFE-GTLCD 543
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1171-1203 2.27e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 2.27e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 134244285   1171 DSGPRCLHNGTCVDLVGGFRCTCPPGYT-GLRCE 1203
Cdd:smart00179    6 ASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
274-311 3.68e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.68e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    274 DVDECQlQPNACHNGGTCFNTLGGHSCVCVNGWT-GESC 311
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 545-580 4.28e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 4.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  545 NVDDC-SPDPC-HHGRCVDGIASFSCACAPGYTGTRCE 580
Cdd:cd00054     1 DIDECaSGNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1872-2008 4.76e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 4.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1872 GRTPLHTAVTADAQGVFQILIRNRSTDLDARMA----DGSTALILAARLAVEGMVEELIASHADVNA-----------VD 1936
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLMEAAPELVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSpratgtffrpgPK 130

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 134244285 1937 EL---GKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDH---LDRLP 2008
Cdd:cd22192   131 NLiyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDLILSYDKEDDlqpLDLVP 208
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1085-1120 6.21e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 6.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285 1085 VDPCL-AQPCQHGGTCRGYMGGYMCECLPGYNGDNCE 1120
Cdd:cd00054     2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
887-922 6.56e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 6.56e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    887 DVDECLS-NPCGPG-TCTDHVASFTCTCPPGY-GGFHCE 922
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 583-618 7.64e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 7.64e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  583 VDECRSQ-PCRHGGKCLDLVDKYLCRCPSGTTGVNCE 618
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
657-686 9.26e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 9.26e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 134244285    657 EINECAS-SPCGEGGSCVDGENGFRCLCPPG 686
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 658-686 9.39e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 9.39e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 134244285  658 INECAS-SPCGEGGSCVDGENGFRCLCPPG 686
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
929-960 1.04e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.04e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 134244285    929 SPSSCFNGGTCVDGVNSFSCLCRPGYT-GAHCQ 960
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
274-305 2.13e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.30  E-value: 2.13e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134244285   274 DVDECQLQPNACHNGGTCFNTLGGHSCVCVNG 305
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
158-188 2.42e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.30  E-value: 2.42e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134244285   158 DVDECRVG-EPCRHGGTCLNTPGSFRCQCPAG 188
Cdd:pfam07645    1 DVDECATGtHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 853-883 2.89e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 2.89e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134244285   853 CDPNPCLNGGSCQDGVGSFSCSCLPGFAGPR 883
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 2115-2215 4.66e-04

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 45.45  E-value: 4.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285  2115 PASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQ------PPGGCVLSLGLLNPVAVPLDWARLpppappgpsfLLP 2188
Cdd:TIGR01645  291 PATVSAIPAAAAVAAAAATAKIMAAEAVAGAAVLGPRaqspatPSSSLPTDIGNKAVVSSAKKEAEE----------VPP 360

                           90       100
                   ....*....|....*....|....*...
gi 134244285  2189 LAPG-PQLLNPGTPVSPQERPPPYLAVP 2215
Cdd:TIGR01645  361 LPQAaPAVVKPGPMEIPTPVPPPGLAIP 388
EGF_CA pfam07645
Calcium-binding EGF domain;
391-422 5.37e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 5.37e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134244285   391 DVDECSIGANPCEHLGRCVNTQGSFLCQCGRG 422
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1084-1120 5.65e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.65e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285   1084 EVDPCL-AQPCQHGGTCRGYMGGYMCECLPGY-NGDNCE 1120
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
545-580 6.48e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 6.48e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    545 NVDDC-SPDPCHHG-RCVDGIASFSCACAPGYT-GTRCE 580
Cdd:smart00179    1 DIDECaSGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
236-272 7.51e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 7.51e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    236 NVDDC-PGHRCLNGGTCVDGVNTYNCQCPPEWT-GQFCT 272
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
583-618 7.97e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.97e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134244285    583 VDECRS-QPCRHGGKCLDLVDKYLCRCPSG-TTGVNCE 618
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 816-843 1.40e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.40e-03
                           10        20
                   ....*....|....*....|....*...
gi 134244285   816 GPAPCGPHGICTNLAGSFSCTCHGGYTG 843
Cdd:pfam12947    4 NNGGCHPNATCTNTGGSFTCTCNDGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1088-1118 2.02e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 2.02e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134244285  1088 CLAQPCQHGGTCRGYMGGYMCECLPGYNGDN 1118
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 2193-2318 2.06e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 43.22  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2193 PQLLNPGTPVSPQ-ERPPPYLAvPGHGEEYPAAGAHSSPPKARFLRVP-SEHPYLTPSPESPEHWASPSPpslsdwseST 2270
Cdd:NF033839  323 PQLEKPKPEVKPQpEKPKPEVK-PQLETPKPEVKPQPEKPKPEVKPQPeKPKPEVKPQPETPKPEVKPQP--------EK 393

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 134244285 2271 PSPATATGamatttgalPAQPLPLSVPsslaQAQTqlgPQPEVTPKRQ 2318
Cdd:NF033839  394 PKPEVKPQ---------PEKPKPEVKP----QPEK---PKPEVKPQPE 425
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 240-268 2.12e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.12e-03
                           10        20
                   ....*....|....*....|....*....
gi 134244285   240 CPGHRCLNGGTCVDGVNTYNCQCPPEWTG 268
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1175-1201 2.23e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.23e-03
                           10        20
                   ....*....|....*....|....*..
gi 134244285  1175 RCLHNGTCVDLVGGFRCTCPPGYTGLR 1201
Cdd:pfam00008    5 PCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 511-539 2.93e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.93e-03
                           10        20
                   ....*....|....*....|....*....
gi 134244285   511 CASTPCRNGAKCVDQPDGYECRCAEGFEG 539
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 620-654 3.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  620 NIDDCAS-NPCTF-GVCRDGINRYDCVCQPGFTGPLC 654
Cdd:cd00054     1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 314-349 3.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  314 NIDDCATA-VCFHGATCHDRVASFYCACPMGKTGLLC 349
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 928-958 8.24e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.24e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134244285   928 CSPSSCFNGGTCVDGVNSFSCLCRPGYTGAH 958
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
314-343 9.91e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 9.91e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 134244285    314 NIDDCATA-VCFHGATCHDRVASFYCACPMG 343
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPG 31
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1818-2043 8.43e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.57  E-value: 8.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1818 ASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRsT 1897
Cdd:COG0666    33 LLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-A 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1898 DLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLF 1977
Cdd:COG0666   112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134244285 1978 LAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLGPLL 2043
Cdd:COG0666   192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALL 257
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1618-1709 8.37e-38

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 137.19  E-value: 8.37e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1618 ERLDFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKDVAsgHKGRREPV 1697
Cdd:cd21704     1 ERLEFPYPIKEVRGEKLEPPPPPVRLLPLLGVAAVILLVILVLGVLVARRKREHSTLWFPEGFFLKKESS--NKNRREPV 78

                          90
                  ....*....|..
gi 134244285 1698 GQDALGMKNMAK 1709
Cdd:cd21704    79 GQDALGMKHIAK 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1813-2024 2.55e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.56  E-value: 2.55e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1813 ADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILI 1892
Cdd:COG0666    61 AALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1893 RNRStDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKE 1972
Cdd:COG0666   141 EAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG 219

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 134244285 1973 ETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLL 2024
Cdd:COG0666   220 KTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1820-2024 8.27e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.38  E-value: 8.27e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1820 IISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIrNRSTDL 1899
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLL-AAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1900 DARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLA 1979
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 134244285 1980 AREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLL 2024
Cdd:COG0666   161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1757-2007 1.10e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.99  E-value: 1.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1757 AADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGgalepmpteedeaddtSASIISDLICQGAQLGARtD 1836
Cdd:COG0666    55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG----------------DLEIVKLLLEAGADVNAR-D 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1837 RTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIrNRSTDLDARMADGSTALILAARL 1916
Cdd:COG0666   118 KDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL-EAGADVNARDNDGETPLHLAAEN 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1917 AVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFA 1996
Cdd:COG0666   197 GHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276

                         250
                  ....*....|.
gi 134244285 1997 NREITDHLDRL 2007
Cdd:COG0666   277 LLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1777-1976 8.11e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.96  E-value: 8.11e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1777 ADGMDVNVRGPDGFTPLMLASFCGgalepmpteedeaddtSASIISDLICQGAQLGARtDRTGETALHLAARYARADAAK 1856
Cdd:COG0666   108 EAGADVNARDKDGETPLHLAAYNG----------------NLEIVKLLLEAGADVNAQ-DNDGNTPLHLAAANGNLEIVK 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1857 RLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRStDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVD 1936
Cdd:COG0666   171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 134244285 1937 ELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPL 1976
Cdd:COG0666   250 KDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1505-1560 3.13e-22

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 91.81  E-value: 3.13e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 134244285  1505 PALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHR 1560
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1577-1637 4.08e-22

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 91.56  E-value: 4.08e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134244285  1577 VIGSVVMLEIDNRLCLQSPenDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPP 1637
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
 1623-1707 9.86e-19

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 82.81  E-value: 9.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1623 PYPLRDVRGEPLE--PPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKdvASGHKGRREPVGQD 1700
Cdd:cd21701     1 PYPIYSVRSEPGPatKTTPPAQLSPLVVAAVCVLLVLVVLGVLVARKRRRHGTLWFPEGFPRTR--ASRRSRRRDPVGQD 78


                  ....*..
gi 134244285 1701 ALGMKNM 1707
Cdd:cd21701    79 SVGLKNL 85
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1623-1707 1.90e-17

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 79.03  E-value: 1.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1623 PYPLRDVRGEPLEPPEPSvpLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKDvASGHKgRREPVGQDAL 1702
Cdd:cd21703     2 PYPLVSVTSEPLKETKFN--LLYLLAVAVAIILLILLLGVLVAKRKRKHGPLWFPEGFILNKE-NSNRK-RREPVGQDAV 77


                  ....*
gi 134244285 1703 GMKNM 1707
Cdd:cd21703    78 GMKNL 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1910-2002 4.74e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 78.23  E-value: 4.74e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285  1910 LILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNgANKDMQDSKeETPLFLAAREGSYEAAK 1989
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 134244285  1990 LLLDHFANREITD 2002
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1779-1992 2.17e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 84.69  E-value: 2.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1779 GMDVNVRGPDGFTPL--MLASFCggalepmpteedeaddTSASIISDLICQGAQLGARtDRTGETALH--LAARYARADA 1854
Cdd:PHA03095  107 GADVNAKDKVGRTPLhvYLSGFN----------------INPKVIRLLLRKGADVNAL-DLYGMTPLAvlLKSRNANVEL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1855 AKRLLDAGADTNAQDHSGRTPLHT-AVTADA-QGVFQILIRnRSTDLDARMADGSTALILAARLAV--EGMVEELIASHA 1930
Cdd:PHA03095  170 LRLLIDAGADVYAVDDRFRSLLHHhLQSFKPrARIVRELIR-AGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGI 248

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134244285 1931 DVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLL 1992
Cdd:PHA03095  249 SINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1943-2024 7.33e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 7.33e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285  1943 LHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDhlDRLPRDVAQERLHQDIVR 2022
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVK 78


                   ..
gi 134244285  2023 LL 2024
Cdd:pfam12796   79 LL 80
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1809-1999 9.33e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.91  E-value: 9.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1809 EEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVF 1888
Cdd:PHA02878  138 KKSKDDIIEAEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIV 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1889 QILIRNRSTdLDARMADGSTAL-ILAARLAVEGMVEELIASHADVNAVDE-LGKSALHwaAAVNNVEATLALLKNGANKD 1966
Cdd:PHA02878  218 HILLENGAS-TDARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLLLEYGADIN 294

                         170       180       190
                  ....*....|....*....|....*....|....
gi 134244285 1967 MQDSKEETPLFLAAREGS-YEAAKLLLDHFANRE 1999
Cdd:PHA02878  295 SLNSYKLTPLSSAVKQYLcINIGRILISNICLLK 328
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1858-1999 4.24e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 68.55  E-value: 4.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1858 LLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGM-VEELIASHADVNAVD 1936
Cdd:PHA02876  259 LYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTEnIRTLIMLGADVNAAD 338

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 134244285 1937 ELGKSALHWAAAVN-NVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANRE 1999
Cdd:PHA02876  339 RLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIE 402
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1858-1969 6.35e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 6.35e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285  1858 LLDAGADTNAQDHSGRTPLHTAvtadaqgvfqilIRNRSTDldarmadgstalilaarlavegMVEELIaSHADVNAVDE 1937
Cdd:pfam12796   16 LLENGADANLQDKNGRTALHLA------------AKNGHLE----------------------IVKLLL-EHADVNLKDN 60

                           90       100       110
                   ....*....|....*....|....*....|..
gi 134244285  1938 lGKSALHWAAAVNNVEATLALLKNGANKDMQD 1969
Cdd:pfam12796   61 -GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 158-195 1.26e-10

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 58.03  E-value: 1.26e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  158 DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCE 195
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1666-1705 2.75e-10

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 58.65  E-value: 2.75e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 134244285 1666 RRKREHSTLWFPEGFslhKDVASGHKGRREPVGQDALGMK 1705
Cdd:cd21702    40 KRRREHGQLWFPEGF---KVSEPSKKKRREPVGEDSVGLK 76
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1858-1997 5.32e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 64.28  E-value: 5.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1858 LLDAGADTNAQDHSGRTPLHTAV---TADAQGVFQILIRNrSTDLDARMADGSTALILAARLA-VEGMVEELIASHADVN 1933
Cdd:PHA03095   33 LLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEA-GADVNAPERCGFTPLHLYLYNAtTLDVIKLLIKAGADVN 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 134244285 1934 AVDELGKSALHWAAAVNNVEATL--ALLKNGANKDMQDSKEETPL--FLAAREGSYEAAKLLLDHFAN 1997
Cdd:PHA03095  112 AKDKVGRTPLHVYLSGFNINPKVirLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGAD 179
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1858-2024 7.56e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.47  E-value: 7.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1858 LLDAGADTNAQDHSGRTPLHTAVT-ADAQGVFQILIRNRSTDlDARMADGSTALILAARLAVEGMVEELIASHADVNAVD 1936
Cdd:PHA02875   54 LMKHGAIPDVKYPDIESELHDAVEeGDVKAVEELLDLGKFAD-DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPN 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1937 ELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANreiTDHLDRLPrDV----- 2011
Cdd:PHA02875  133 TDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN---IDYFGKNG-CVaalcy 208

                         170
                  ....*....|...
gi 134244285 2012 AQERLHQDIVRLL 2024
Cdd:PHA02875  209 AIENNKIDIVRLF 221
EGF_CA smart00179
Calcium-binding EGF-like domain;
158-195 9.24e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 55.72  E-value: 9.24e-10
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    158 DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYT-GPLCE 195
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1666-1705 2.46e-09

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 56.25  E-value: 2.46e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 134244285 1666 RRKREHSTLWFPEGFSLHKDvASGHKgRREPVGQDALGMK 1705
Cdd:cd21705    52 RRQREHGALWLPPGFARHRD-PNPHR-RREPVGEDAIGLK 89
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1384-1418 1.35e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.14  E-value: 1.35e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 134244285  1384 EPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCS 1418
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
Ank_4 pfam13637
Ankyrin repeats (many copies);
1941-1992 1.86e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.28  E-value: 1.86e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 134244285  1941 SALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLL 1992
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1425-1458 1.99e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 1.99e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 134244285  1425 WRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1458
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDC 34
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1421-1458 2.14e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.94  E-value: 2.14e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134244285   1421 VGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1458
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1732-1979 2.18e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 59.69  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1732 LKVEEPGMGAEEAVDCRQWTQHHLVAAdirvaPAMALTPPQgdADADGMDVNVRGPDGFTPLMLASFCGGALEPMPTeed 1811
Cdd:PHA02876  257 LLLYDAGFSVNSIDDCKNTPLHHASQA-----PSLSRLVPK--LLERGADVNAKNIKGETPLYLMAKNGYDTENIRT--- 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1812 eaddtsasiisdLICQGAQLGArTDRTGETALHLAARYARADAAK-RLLDAGADTNAQDHSGRTPLHTAVTADAqgvfqI 1890
Cdd:PHA02876  327 ------------LIMLGADVNA-ADRLYITPLHQASTLDRNKDIViTLLELGANVNARDYCDKTPIHYAAVRNN-----V 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1891 LIRNRSTDLDARMADGSTALILAARLAVEGM-----VEELIASHADVNAVDELGKSALHWAAAVN-NVEATLALLKNGAN 1964
Cdd:PHA02876  389 VIINTLLDYGADIEALSQKIGTALHFALCGTnpymsVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGAD 468

                         250
                  ....*....|....*
gi 134244285 1965 KDMQDSKEETPLFLA 1979
Cdd:PHA02876  469 VNAINIQNQYPLLIA 483
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1474-1500 2.33e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 2.33e-08
                           10        20
                   ....*....|....*....|....*..
gi 134244285  1474 YCADHFADGRCDQGCNTEECGWDGLDC 1500
Cdd:pfam00066    8 YCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-846 3.11e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 3.11e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  810 DVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSC 846
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1380-1417 4.04e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.17  E-value: 4.04e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134244285   1380 EVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDC 1417
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2045-2318 4.17e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 4.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2045 PPGAFLPGLKAAQSGSKKSRRPPGKaglgPQGPRGRGKKLTLACPGPLADSSV-TLSPVDSLD-SPRPFGGPPASPGGfP 2122
Cdd:PHA03247 2680 PQRPRRRAARPTVGSLTSLADPPPP----PPTPEPAPHALVSATPLPPGPAAArQASPALPAApAPPAVPAGPATPGG-P 2754

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2123 LEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLA------PGPQLL 2196
Cdd:PHA03247 2755 ARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAspagplPPPTSA 2834

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2197 NPGTPVSPQERPPPYLA-----VPG-----HGEEYPAAGAHSSPPKARFLRVPSehPYLTPSPESpehwaSPSPPSlsdw 2266
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPlggsvAPGgdvrrRPPSRSPAAKPAAPARPPVRRLAR--PAVSRSTES-----FALPPD---- 2903

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 134244285 2267 sESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQ 2318
Cdd:PHA03247 2904 -QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGE 2954
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 469-505 8.37e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 8.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  469 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFSGSTCQ 505
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 391-429 1.76e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.76e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 134244285  391 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 429
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1858-1997 1.80e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.13  E-value: 1.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1858 LLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRN----------------------RSTDLDARMADGSTALILAAR 1915
Cdd:PHA02874   54 FIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNgvdtsilpipciekdmiktildCGIDVNIKDAELKTFLHYAIK 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1916 LAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHF 1995
Cdd:PHA02874  134 KGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHG 213


                  ..
gi 134244285 1996 AN 1997
Cdd:PHA02874  214 NH 215
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 849-884 2.39e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.39e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  849 DINDCD-PNPCLNGGSCQDGVGSFSCSCLPGFAGPRC 884
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1835-1973 4.17e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 55.64  E-value: 4.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1835 TDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNrstdldARMADGSTA---LI 1911
Cdd:PLN03192  554 GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHF------ASISDPHAAgdlLC 627

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134244285 1912 LAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEE 1973
Cdd:PLN03192  628 TAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDD 689
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1473-1500 5.48e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 47.71  E-value: 5.48e-07
                            10        20
                    ....*....|....*....|....*...
gi 134244285   1473 KYCADHFADGRCDQGCNTEECGWDGLDC 1500
Cdd:smart00004   11 AQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 431-467 8.05e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  431 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFTGTYCE 467
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
391-429 9.37e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 9.37e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 134244285    391 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYT-GPRCE 429
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
810-847 9.75e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 9.75e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    810 DVDECAGPAPCGPHGICTNLAGSFSCTCHGGYT-GPSCD 847
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1171-1203 9.79e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 9.79e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 134244285 1171 DSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE 1203
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1858-1913 1.25e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.34  E-value: 1.25e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 134244285  1858 LLDAG-ADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRStDLDARMADGSTALILA 1913
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV-DLNLKDEEGLTALDLA 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
469-505 1.39e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.39e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    469 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFS-GSTCQ 505
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 274-311 1.45e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.45e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  274 DVDECQlQPNACHNGGTCFNTLGGHSCVCVNGWTGESC 311
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2038-2319 1.65e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2038 GLGPLLCPPGAFLPGLKAAQSGSKKSRRP-----PGKAGLGPQGPRGRGKKLTLACPGPLADSSvtlsPVDSLDSPRPFG 2112
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRArrlgrAAQASSPPQRPRRRAARPTVGSLTSLADPP----PPPPTPEPAPHA 2714

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2113 GPPASP---------GGFPLEGPYAAATATAVSLAQLGGPGRAGlGRQPPGGCVLSLGLLNPVAVPLdwARLPPPAPPGP 2183
Cdd:PHA03247 2715 LVSATPlppgpaaarQASPALPAAPAPPAVPAGPATPGGPARPA-RPPTTAGPPAPAPPAAPAAGPP--RRLTRPAVASL 2791

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2184 SFLLPLAPGPQLLNPGT-PVSPQERPPPYLAVPGHGEEYPAAGAHSSPPKarflrvPSEHPyltPSPESPEHWASPS--- 2259
Cdd:PHA03247 2792 SESRESLPSPWDPADPPaAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP------PPGPP---PPSLPLGGSVAPGgdv 2862

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 134244285 2260 ---PPSLSDWSESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQV 2319
Cdd:PHA03247 2863 rrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP 2925
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1858-2002 1.92e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.75  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1858 LLDAGADTNAQDHSGRTPLHTAVTADAQGVFQI-LIRNRSTDLDARMADGSTALilaaRLAVEG------MVEELIASHA 1930
Cdd:PHA03100   92 LLEYGANVNAPDNNGITPLLYAISKKSNSYSIVeYLLDNGANVNIKNSDGENLL----HLYLESnkidlkILKLLIDKGV 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1931 DVNA----------------VDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDH 1994
Cdd:PHA03100  168 DINAknrvnyllsygvpiniKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNN 247


                  ....*...
gi 134244285 1995 FANREITD 2002
Cdd:PHA03100  248 GPSIKTII 255
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 507-542 1.96e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  507 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFEGTLC 542
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 929-960 2.39e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.39e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 134244285  929 SPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQ 960
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1858-1997 2.91e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.36  E-value: 2.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1858 LLDAGADTN--AQDHSGRTPLHTAVTADAQGVFQI--LIRNRSTDLDARMADGSTALILAARLAVEG--MVEELIASHAD 1931
Cdd:PHA03100   54 LLDNGADINssTKNNSTPLHYLSNIKYNLTDVKEIvkLLLEYGANVNAPDNNGITPLLYAISKKSNSysIVEYLLDNGAN 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1932 VNAVDELGKSALHWAAAVNNVEATLA------------------LLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLD 1993
Cdd:PHA03100  134 VNIKNSDGENLLHLYLESNKIDLKILkllidkgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLD 213


                  ....
gi 134244285 1994 HFAN 1997
Cdd:PHA03100  214 LGAN 217
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2041-2316 4.07e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 4.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2041 PLLCPPGAFLPGLKAAQSGSKKSRRPPGKA--------GLGPQGPRGRgkkltlaCPGPLADSSVTLSPVDSL--DSPRP 2110
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPRPAPRPSEPAvtsrarrpDAPPQSARPR-------APVDDRGDPRGPAPPSPLppDTHAP 2624

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2111 FGGPPA-SPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQppggcVLSLG-LLNPVAVPLDWAR--LPPPAPPGPSFL 2186
Cdd:PHA03247 2625 DPPPPSpSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR-----ARRLGrAAQASSPPQRPRRraARPTVGSLTSLA 2699

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2187 LPLAPGPQLLNPGTPVSPQERPPPylAVPGHGEEYPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPP----- 2261
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPP--GPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPaapaa 2777

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 134244285 2262 ------------SLSDWSESTPSPATATGAMATTTGALPAQPlPLSVPSSLAQAQTQLGPQPEVTPK 2316
Cdd:PHA03247 2778 gpprrltrpavaSLSESRESLPSPWDPADPPAAVLAPAAALP-PAASPAGPLPPPTSAQPTAPPPPP 2843
EGF_CA smart00179
Calcium-binding EGF-like domain;
431-467 4.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.41e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    431 DVNECLS-GPCRNQATCLDRIGQFTCICMAGFT-GTYCE 467
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 887-922 4.70e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 4.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  887 DVDECLS-NPCGP-GTCTDHVASFTCTCPPGYGGFHCE 922
Cdd:cd00054     1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
849-884 5.11e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 5.11e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134244285    849 DINDC-DPNPCLNGGSCQDGVGSFSCSCLPGF-AGPRC 884
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1858-1992 6.38e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.79  E-value: 6.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1858 LLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNrSTDLDARMADGSTAL---ILAARLAVEGMVEELiASHADVNA 1934
Cdd:PLN03192  544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKH-ACNVHIRDANGNTALwnaISAKHHKIFRILYHF-ASISDPHA 621

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 134244285 1935 VDELgksaLHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLL 1992
Cdd:PLN03192  622 AGDL----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1122-1158 6.50e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 6.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285 1122 DVDECASQ-PCQHGGSCIDLVARYLCSCPPGTLGVLCE 1158
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2188-2318 1.21e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.92  E-value: 1.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285  2188 PLAPGPQLLNPGTPVSPQERPPPYL-AVPGHGE----EYPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPS 2262
Cdd:pfam03154  179 GAASPPSPPPPGTTQAATAGPTPSApSVPPQGSpatsQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPP 258

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 134244285  2263 LSDWSESTPSPATATG--------AMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQ 2318
Cdd:pfam03154  259 SQVSPQPLPQPSLHGQmppmphslQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQ 322
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1890-2024 1.39e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.64  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1890 ILIRNRSTDLDARMAdgsTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQD 1969
Cdd:PLN03192  512 LLGDNGGEHDDPNMA---SNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRD 588

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1970 SKEETPLF-------------------------------LAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQ 2018
Cdd:PLN03192  589 ANGNTALWnaisakhhkifrilyhfasisdphaagdllcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHV 668


                  ....*.
gi 134244285 2019 DIVRLL 2024
Cdd:PLN03192  669 DMVRLL 674
EGF_CA smart00179
Calcium-binding EGF-like domain;
1122-1158 1.39e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.39e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285   1122 DVDECAS-QPCQHGGSCIDLVARYLCSCPPG-TLGVLCE 1158
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 236-272 1.51e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.51e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  236 NVDDC-PGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 272
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1929-1979 1.54e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.26  E-value: 1.54e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 134244285  1929 HADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLA 1979
Cdd:pfam13857    6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
507-543 1.76e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.76e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    507 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFE-GTLCD 543
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1805-2021 1.81e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.58  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1805 PMPTEEDEaddtsasIISDLICQGAQLGARtDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADA 1884
Cdd:PHA02874   98 PIPCIEKD-------MIKTILDCGIDVNIK-DAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNF 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1885 QGVFQILIRNRSTdLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNnvEATLALLKNGAN 1964
Cdd:PHA02874  170 FDIIKLLLEKGAY-ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN--RSAIELLINNAS 246

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 134244285 1965 KDMQDSKEETPLFLAAR-EGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIV 2021
Cdd:PHA02874  247 INDQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPV 304
JMTM_dNotch cd21706
juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic ...
 1665-1710 1.86e-05

juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic locus Notch protein (dNotch) and similar proteins; Drosophila melanogaster neurogenic locus Notch protein (dNotch) is an essential signaling protein which has a major role in many developmental processes. It functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. It regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction. It also regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, it is involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt. It might also regulate dpn expression through the activation of the transcriptional regulator Su(H). This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of dNotch, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411989  Cd Length: 90  Bit Score: 45.33  E-value: 1.86e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 134244285 1665 ARRKREHSTLWFPEGFSLHK-DVASGHKGRREPVGQDalgMKNMAKG 1710
Cdd:cd21706    47 TQRKRARGITWFPEGFFTTSsSQRRRRSRRRGPDGQE---MRNLKKQ 90
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 161-192 2.21e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 43.23  E-value: 2.21e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 134244285  161 ECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGP 192
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1171-1203 2.27e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 2.27e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 134244285   1171 DSGPRCLHNGTCVDLVGGFRCTCPPGYT-GLRCE 1203
Cdd:smart00179    6 ASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2045-2318 2.54e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 2.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2045 PPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADSSV-----------TLSPVDSLDSPRPFGG 2113
Cdd:PHA03247 2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPpqrprrraarpTVGSLTSLADPPPPPP 2706

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2114 PPASP------------------GGFPLEGPYAAATATAVSLAQLGGPGRAGlGRQPPGGCVLSLGLLNPVAVPLdwARL 2175
Cdd:PHA03247 2707 TPEPAphalvsatplppgpaaarQASPALPAAPAPPAVPAGPATPGGPARPA-RPPTTAGPPAPAPPAAPAAGPP--RRL 2783

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2176 PPPAPPGPSFLLPLAPGPQLLNPGT-PVSPQERPPPYLAVPGHGEEYPAAGAHSSPPKarflrvPSEHPyltPSPESPEH 2254
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPaAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP------PPGPP---PPSLPLGG 2854

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 134244285 2255 WASPSPPsLSDWSESTPSPATATGAMATTTGALPAQPLPlsvPSSLAQAQTQLGPQPEVTPKRQ 2318
Cdd:PHA03247 2855 SVAPGGD-VRRRPPSRSPAAKPAAPARPPVRRLARPAVS---RSTESFALPPDQPERPPQPQAP 2914
EGF_CA smart00179
Calcium-binding EGF-like domain;
274-311 3.68e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.68e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    274 DVDECQlQPNACHNGGTCFNTLGGHSCVCVNGWT-GESC 311
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 545-580 4.28e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 4.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134244285  545 NVDDC-SPDPC-HHGRCVDGIASFSCACAPGYTGTRCE 580
Cdd:cd00054     1 DIDECaSGNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1872-2008 4.76e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 4.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1872 GRTPLHTAVTADAQGVFQILIRNRSTDLDARMA----DGSTALILAARLAVEGMVEELIASHADVNA-----------VD 1936
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLMEAAPELVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSpratgtffrpgPK 130

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 134244285 1937 EL---GKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDH---LDRLP 2008
Cdd:cd22192   131 NLiyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDLILSYDKEDDlqpLDLVP 208
Ank_4 pfam13637
Ankyrin repeats (many copies);
1906-1959 4.95e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 4.95e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 134244285  1906 GSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALL 1959
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1874-1994 5.33e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 48.36  E-value: 5.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1874 TPLHTAVTADAqgVFQILIRNRSTDLDARMADGSTaliLAARLavegmveeLIASHADVNAVDELGKSALHWAAAVNNVE 1953
Cdd:PTZ00322   63 TPDHNLTTEEV--IDPVVAHMLTVELCQLAASGDA---VGARI--------LLTGGADPNCRDYDGRTPLHIACANGHVQ 129

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 134244285 1954 ATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDH 1994
Cdd:PTZ00322  130 VVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1858-2024 5.63e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 48.34  E-value: 5.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1858 LLDAGADTNAQDHSGRTPLHTAVTA-DAQGVFQILIRNRSTDLDARMADGSTA----------LILAARL---------- 1916
Cdd:PHA02878   56 LLTRGHNVNQPDHRDLTPLHIICKEpNKLGMKEMIRSINKCSVFYTLVAIKDAfnnrnveifkIILTNRYkniqtidlvy 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1917 --------AVEGMVEELIASH-ADVNAVDE-LGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYE 1986
Cdd:PHA02878  136 idkkskddIIEAEITKLLLSYgADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKP 215

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 134244285 1987 AAKLLLDHFANREITDHLDRLPRDVAQERLHQ-DIVRLL 2024
Cdd:PHA02878  216 IVHILLENGASTDARDKCGNTPLHISVGYCKDyDILKLL 254
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1085-1120 6.21e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 6.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285 1085 VDPCL-AQPCQHGGTCRGYMGGYMCECLPGYNGDNCE 1120
Cdd:cd00054     2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
887-922 6.56e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 6.56e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    887 DVDECLS-NPCGPG-TCTDHVASFTCTCPPGY-GGFHCE 922
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 583-618 7.64e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 7.64e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  583 VDECRSQ-PCRHGGKCLDLVDKYLCRCPSGTTGVNCE 618
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
657-686 9.26e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 9.26e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 134244285    657 EINECAS-SPCGEGGSCVDGENGFRCLCPPG 686
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 658-686 9.39e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 9.39e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 134244285  658 INECAS-SPCGEGGSCVDGENGFRCLCPPG 686
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
929-960 1.04e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.04e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 134244285    929 SPSSCFNGGTCVDGVNSFSCLCRPGYT-GAHCQ 960
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1944-2024 1.32e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1944 HWAAAVNNVEATLaLLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRL 2023
Cdd:PTZ00322   88 QLAASGDAVGARI-LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                  .
gi 134244285 2024 L 2024
Cdd:PTZ00322  167 L 167
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1802-2025 1.52e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.98  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1802 ALEPMPTEEDEADDTSASIISDLICQGAQLGARtDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVT 1881
Cdd:PHA02876  142 SIEYMKLIKERIQQDELLIAEMLLEGGADVNAK-DIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVD 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1882 ADAQGVFQILIRNRS----TDLDARMADGSTALILAARLAVEGMveeliashaDVNAVDELGKSALHWAAAVNNVEATL- 1956
Cdd:PHA02876  221 SKNIDTIKAIIDNRSninkNDLSLLKAIRNEDLETSLLLYDAGF---------SVNSIDDCKNTPLHHASQAPSLSRLVp 291

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134244285 1957 ALLKNGANKDMQDSKEETPLFLAAREG-SYEAAKLLLDHFANREITDHLDRLPRDVAQ--ERLHQDIVRLLD 2025
Cdd:PHA02876  292 KLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQAStlDRNKDIVITLLE 363
EGF_CA pfam07645
Calcium-binding EGF domain;
274-305 2.13e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.30  E-value: 2.13e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134244285   274 DVDECQLQPNACHNGGTCFNTLGGHSCVCVNG 305
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
158-188 2.42e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.30  E-value: 2.42e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134244285   158 DVDECRVG-EPCRHGGTCLNTPGSFRCQCPAG 188
Cdd:pfam07645    1 DVDECATGtHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 853-883 2.89e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 2.89e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134244285   853 CDPNPCLNGGSCQDGVGSFSCSCLPGFAGPR 883
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 2097-2319 4.37e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.85  E-value: 4.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2097 VTLSPVDSLdsprpFGGPPASPG----------GFPLEGPYAAATATAVSLAQLGGPGRAgLGRQPPggcvlSLGLLNPV 2166
Cdd:PRK10263  285 VAADPDDVL-----FSGNRATQPeydeydpllnGAPITEPVAVAAAATTATQSWAAPVEP-VTQTPP-----VASVDVPP 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2167 AVP-LDWARlpppappgpsfllplAPGPQLLNPGTPVSPQERPP-PYLAVPG--HGEEYPAAGAHSSPPKARFLRVPSEH 2242
Cdd:PRK10263  354 AQPtVAWQP---------------VPGPQTGEPVIAPAPEGYPQqSQYAQPAvqYNEPLQQPVQPQQPYYAPAAEQPAQQ 418

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 134244285 2243 PYLTPSPESPEHWASPSPPSLSDWSESTPSPATATGAMATTTGALPAQPLPLSVPSS-LAQAQTQLGPQPEVTPKRQV 2319
Cdd:PRK10263  419 PYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEpLYQQPQPVEQQPVVEPEPVV 496
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 2115-2215 4.66e-04

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 45.45  E-value: 4.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285  2115 PASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQ------PPGGCVLSLGLLNPVAVPLDWARLpppappgpsfLLP 2188
Cdd:TIGR01645  291 PATVSAIPAAAAVAAAAATAKIMAAEAVAGAAVLGPRaqspatPSSSLPTDIGNKAVVSSAKKEAEE----------VPP 360

                           90       100
                   ....*....|....*....|....*...
gi 134244285  2189 LAPG-PQLLNPGTPVSPQERPPPYLAVP 2215
Cdd:TIGR01645  361 LPQAaPAVVKPGPMEIPTPVPPPGLAIP 388
EGF_CA pfam07645
Calcium-binding EGF domain;
391-422 5.37e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 5.37e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 134244285   391 DVDECSIGANPCEHLGRCVNTQGSFLCQCGRG 422
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1084-1120 5.65e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.65e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285   1084 EVDPCL-AQPCQHGGTCRGYMGGYMCECLPGY-NGDNCE 1120
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
545-580 6.48e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 6.48e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    545 NVDDC-SPDPCHHG-RCVDGIASFSCACAPGYT-GTRCE 580
Cdd:smart00179    1 DIDECaSGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1808-1901 7.23e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 7.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1808 TEEDEADDTSASIISDLICQ----GAQLGART-----------DRTGETALHLAARYARADAAKRLLDAGADTNAQDHSG 1872
Cdd:PTZ00322   69 TTEEVIDPVVAHMLTVELCQlaasGDAVGARIlltggadpncrDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDG 148

                          90       100
                  ....*....|....*....|....*....
gi 134244285 1873 RTPLHTAVTADAQGVFQILIRNRSTDLDA 1901
Cdd:PTZ00322  149 KTPLELAEENGFREVVQLLSRHSQCHFEL 177
EGF_CA smart00179
Calcium-binding EGF-like domain;
236-272 7.51e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 7.51e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 134244285    236 NVDDC-PGHRCLNGGTCVDGVNTYNCQCPPEWT-GQFCT 272
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
583-618 7.97e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.97e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 134244285    583 VDECRS-QPCRHGGKCLDLVDKYLCRCPSG-TTGVNCE 618
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1889-2024 1.17e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.80  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1889 QILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGA----- 1963
Cdd:PHA02874   18 EKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVdtsil 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 134244285 1964 -----NKDM-------------QDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLL 2024
Cdd:PHA02874   98 pipciEKDMiktildcgidvniKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLL 176
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 167-192 1.34e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.34e-03
                           10        20
                   ....*....|....*....|....*.
gi 134244285   167 PCRHGGTCLNTPGSFRCQCPAGYTGP 192
Cdd:pfam00008    5 PCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 816-843 1.40e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.40e-03
                           10        20
                   ....*....|....*....|....*...
gi 134244285   816 GPAPCGPHGICTNLAGSFSCTCHGGYTG 843
Cdd:pfam12947    4 NNGGCHPNATCTNTGGSFTCTCNDGYTG 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 813-844 1.64e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.84  E-value: 1.64e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 134244285  813 ECAGPAPCGPHGICTNLAGSFSCTCHGGYTGP 844
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1088-1118 2.02e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 2.02e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134244285  1088 CLAQPCQHGGTCRGYMGGYMCECLPGYNGDN 1118
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 2193-2318 2.06e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 43.22  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2193 PQLLNPGTPVSPQ-ERPPPYLAvPGHGEEYPAAGAHSSPPKARFLRVP-SEHPYLTPSPESPEHWASPSPpslsdwseST 2270
Cdd:NF033839  323 PQLEKPKPEVKPQpEKPKPEVK-PQLETPKPEVKPQPEKPKPEVKPQPeKPKPEVKPQPETPKPEVKPQP--------EK 393

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 134244285 2271 PSPATATGamatttgalPAQPLPLSVPsslaQAQTqlgPQPEVTPKRQ 2318
Cdd:NF033839  394 PKPEVKPQ---------PEKPKPEVKP----QPEK---PKPEVKPQPE 425
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 240-268 2.12e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.12e-03
                           10        20
                   ....*....|....*....|....*....
gi 134244285   240 CPGHRCLNGGTCVDGVNTYNCQCPPEWTG 268
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1837-1967 2.21e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.06  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1837 RTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTdLDARMADGSTALILAARL 1916
Cdd:PHA02875  100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKAC-LDIEDCCGCTPLIIAMAK 178

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 134244285 1917 AVEGMVEELIASHADVNAVDELGKSALHWAAAVNN-VEATLALLKNGANKDM 1967
Cdd:PHA02875  179 GDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNkIDIVRLFIKRGADCNI 230
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1175-1201 2.23e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.23e-03
                           10        20
                   ....*....|....*....|....*..
gi 134244285  1175 RCLHNGTCVDLVGGFRCTCPPGYTGLR 1201
Cdd:pfam00008    5 PCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1176-1201 2.84e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 134244285 1176 CLHNGTCVDLVGGFRCTCPPGYTGLR 1201
Cdd:cd00053     8 CSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 511-539 2.93e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.93e-03
                           10        20
                   ....*....|....*....|....*....
gi 134244285   511 CASTPCRNGAKCVDQPDGYECRCAEGFEG 539
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 2199-2319 3.26e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.75  E-value: 3.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2199 GTPVSPQERPPPYLAvPGH-----GEEYPAAGA-----HSSPPKARFLRV-----------PSEHPYLTPSPESPEHWAS 2257
Cdd:PTZ00449  509 EPPEGPEASGLPPKA-PGDkegeeGEHEDSKESdepkeGGKPGETKEGEVgkkpgpakehkPSKIPTLSKKPEFPKDPKH 587

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 134244285 2258 PSPPslsdwsESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQV 2319
Cdd:PTZ00449  588 PKDP------EEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPS 643
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2026-2315 3.27e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2026 QPSGPRSPPGPHGLGPLLCPPGAFLPGLKAAqsgskksrRPPgkaglgPQGPRGRGKKL----TLACPGPLADSSVTLSP 2101
Cdd:PHA03247 2594 QSARPRAPVDDRGDPRGPAPPSPLPPDTHAP--------DPP------PPSPSPAANEPdphpPPTVPPPERPRDDPAPG 2659

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2102 VDSLDSPRPFGGPPASPGGfPLEGPY-AAATATAVSLAQLGGPGRAGLGRQPPGGCVLSlgllnpvAVPLDWARLPPPAP 2180
Cdd:PHA03247 2660 RVSRPRRARRLGRAAQASS-PPQRPRrRAARPTVGSLTSLADPPPPPPTPEPAPHALVS-------ATPLPPGPAAARQA 2731

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2181 PGPSFLLPLAPgPQLLNPGTPVSPQERPPPYLavpghgeeyPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSP 2260
Cdd:PHA03247 2732 SPALPAAPAPP-AVPAGPATPGGPARPARPPT---------TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSP 2801

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 134244285 2261 PSLSDWSESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQaqtqlGPQPEVTP 2315
Cdd:PHA03247 2802 WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP-----GPPPPSLP 2851
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 383-424 3.37e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.22  E-value: 3.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 134244285  383 FTGGACdQDVDECSIGANPCEHLgrCVNTQGSFLCQCGRGYT 424
Cdd:cd01475   179 FQGKIC-VVPDLCATLSHVCQQV--CISTPGSYLCACTEGYA 217
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 620-654 3.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  620 NIDDCAS-NPCTF-GVCRDGINRYDCVCQPGFTGPLC 654
Cdd:cd00054     1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 314-349 3.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 134244285  314 NIDDCATA-VCFHGATCHDRVASFYCACPMGKTGLLC 349
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1907-1992 4.66e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.31  E-value: 4.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1907 STALILAARlavEGMVEE----LIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNG---ANKDMQDS--KEETPLF 1977
Cdd:cd22192    18 ESPLLLAAK---ENDVQAikklLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQGETALH 94

                          90
                  ....*....|....*
gi 134244285 1978 LAAREGSYEAAKLLL 1992
Cdd:cd22192    95 IAVVNQNLNLVRELI 109
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 854-883 5.38e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 5.38e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 134244285  854 DPNPCLNGGSCQDGVGSFSCSCLPGFAGPR 883
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1839-2006 5.46e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 42.05  E-value: 5.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1839 GETALHLAARYARADAAKRLLDAGADTNAQdhsgrtplhtavtadAQGVFqilirNRSTDLDARMADGSTALILAARLAV 1918
Cdd:cd22194   141 GQTALNIAIERRQGDIVKLLIAKGADVNAH---------------AKGVF-----FNPKYKHEGFYFGETPLALAACTNQ 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1919 EGMVEELIA-SHADVNAVDELGKSALHWAAAV-NNVEATLA--------LLKNGANKD---MQDSKEETPLFLAAREGSY 1985
Cdd:cd22194   201 PEIVQLLMEkESTDITSQDSRGNTVLHALVTVaEDSKTQNDfvkrmydmILLKSENKNletIRNNEGLTPLQLAAKMGKA 280

                         170       180
                  ....*....|....*....|....*
gi 134244285 1986 EaaklLLDHFANREITD----HLDR 2006
Cdd:cd22194   281 E----ILKYILSREIKEkpnrSLSR 301
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1176-1197 6.16e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.16  E-value: 6.16e-03
                           10        20
                   ....*....|....*....|..
gi 134244285  1176 CLHNGTCVDLVGGFRCTCPPGY 1197
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 400-427 7.04e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 7.04e-03
                           10        20
                   ....*....|....*....|....*...
gi 134244285   400 NPCEHLGRCVNTQGSFLCQCGRGYTGPR 427
Cdd:pfam00008    4 NPCSNGGTCVDTPGGYTCICPEGYTGKR 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 245-266 7.49e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 7.49e-03
                           10        20
                   ....*....|....*....|..
gi 134244285   245 CLNGGTCVDGVNTYNCQCPPEW 266
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 928-958 8.24e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.24e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 134244285   928 CSPSSCFNGGTCVDGVNSFSCLCRPGYTGAH 958
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2067-2273 9.04e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 9.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2067 PGKAGLGPQGPRGRGKKLTLACPGPLADSSVTLSPVDSLDSPrPFGGPPASPGGFPLEGPYAAATA-TAVSLAQLGGPGR 2145
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAP-AAAPAAAAAARAVAAAPARRSPApEALAAARQASARG 443

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 2146 AGLGRQPPGGcvlslgllnPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGTPVSPQERPP-----PYLAVPGHGEE 2220
Cdd:PRK12323  444 PGGAPAPAPA---------PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPweelpPEFASPAPAQP 514

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 134244285 2221 YPAAG----------AHSSPPKARFLRVPSEHPYLTPSPES-PEHWASPSPPSLSDWSESTPSP 2273
Cdd:PRK12323  515 DAAPAgwvaesipdpATADPDDAFETLAPAPAAAPAPRAAAaTEPVVAPRPPRASASGLPDMFD 578
PHA02946 PHA02946
ankyin-like protein; Provisional
 1835-1978 9.11e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.19  E-value: 9.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1835 TDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQI-LIRNRSTDLDARMADGSTALILA 1913
Cdd:PHA02946   68 TDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERInLLVQYGAKINNSVDEEGCGPLLA 147

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 134244285 1914 ARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLA--LLKNGANKDMQDSKEETPLFL 1978
Cdd:PHA02946  148 CTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDNPKASTIswMMKLGISPSKPDHDGNTPLHI 214
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1839-1987 9.13e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 9.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1839 GETALHLAARYARADAAKRLLDAGAD-----TNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMAD-------- 1905
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLMEAAPElvnepMTSDLYQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpgpk 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134244285 1906 -----GSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNveATLA------LLKNGANKD------MQ 1968
Cdd:cd22192   131 nliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPN--KTFAcqmydlILSYDKEDDlqpldlVP 208

                         170
                  ....*....|....*....
gi 134244285 1969 DSKEETPLFLAAREGSYEA 1987
Cdd:cd22192   209 NNQGLTPFKLAAKEGNIVM 227
EGF_CA pfam07645
Calcium-binding EGF domain;
810-837 9.20e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 9.20e-03
                           10        20
                   ....*....|....*....|....*....
gi 134244285   810 DVDECA-GPAPCGPHGICTNLAGSFSCTC 837
Cdd:pfam07645    1 DVDECAtGTHNCPANTVCVNTIGSFECRC 29
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 277-309 9.44e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 9.44e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 134244285  277 ECQlQPNACHNGGTCFNTLGGHSCVCVNGWTGE 309
Cdd:cd00053     1 ECA-ASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
314-343 9.91e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 9.91e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 134244285    314 NIDDCATA-VCFHGATCHDRVASFYCACPMG 343
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPG 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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