NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4557701|ref|NP_000413|]
View 

keratin, type I cytoskeletal 17 [Homo sapiens]

Protein Classification

intermediate filament family protein( domain architecture ID 11981676)

intermediate filament (IF) family protein is a primordial component of the cytoskeleton and the nuclear envelope; such as type I keratins

CATH:  1.20.5.170
Gene Ontology:  GO:0005882
PubMed:  2183847|12596228|28101862

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
84-394 2.20e-139

Intermediate filament protein;


:

Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 401.22  E-value: 2.20e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     84 EKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQRQAPGPARDYSQYYRTIEELQNKILTATVDNANILLQIDNAR 163
Cdd:pfam00038   2 EKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNLR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701    164 LAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVG-GEINVEMD 242
Cdd:pfam00038  82 LAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSdTQVNVEMD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701    243 AAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKA 322
Cdd:pfam00038 162 AARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQKA 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4557701    323 SLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAH 394
Cdd:pfam00038 242 SLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
84-394 2.20e-139

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 401.22  E-value: 2.20e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     84 EKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQRQAPGPARDYSQYYRTIEELQNKILTATVDNANILLQIDNAR 163
Cdd:pfam00038   2 EKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNLR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701    164 LAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVG-GEINVEMD 242
Cdd:pfam00038  82 LAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSdTQVNVEMD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701    243 AAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKA 322
Cdd:pfam00038 162 AARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQKA 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4557701    323 SLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAH 394
Cdd:pfam00038 242 SLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 183-389 2.20e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.60  E-value: 2.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     183 VEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEE---EMNALRGQVGG-EINVEMDAAPGVDLSRILNEMRD 258
Cdd:TIGR02168  682 LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEElsrQISALRKDLARlEAEVEQLEERIAQLSKELTELEA 761

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     259 QYEKMAEKNRK--DAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAETENRYC 336
Cdd:TIGR02168  762 EIEELEERLEEaeEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLE 841

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 4557701     337 V---QLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLE 389
Cdd:TIGR02168  842 DleeQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELE 897
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 138-393 5.83e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.86  E-value: 5.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  138 IEELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAY 217
Cdd:COG1196 248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAE 327

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  218 LKKNHEEEMNALRGQVGGEINVEMDAApgvDLSRILNEMRDQYEKMAEKNRKDAEDWffsktEELNREVATNSELVQSGK 297
Cdd:COG1196 328 LEEELEELEEELEELEEELEEAEEELE---EAEAELAEAEEALLEAEAELAEAEEEL-----EELAEELLEALRAAAELA 399

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  298 SEISELRRTMQALEIELQSQLSMKASLEGNLAETENrycvQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRL 377
Cdd:COG1196 400 AQLEELEEAEEALLERLERLEEELEELEEALAELEE----EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALL 475

                       250
                ....*....|....*.
gi 4557701  378 EQEIATYRRLLEGEDA 393
Cdd:COG1196 476 EAALAELLEELAEAAA 491
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
84-394 2.20e-139

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 401.22  E-value: 2.20e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     84 EKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQRQAPGPARDYSQYYRTIEELQNKILTATVDNANILLQIDNAR 163
Cdd:pfam00038   2 EKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNLR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701    164 LAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVG-GEINVEMD 242
Cdd:pfam00038  82 LAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSdTQVNVEMD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701    243 AAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKA 322
Cdd:pfam00038 162 AARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQKA 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4557701    323 SLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAH 394
Cdd:pfam00038 242 SLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 183-389 2.20e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.60  E-value: 2.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     183 VEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEE---EMNALRGQVGG-EINVEMDAAPGVDLSRILNEMRD 258
Cdd:TIGR02168  682 LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEElsrQISALRKDLARlEAEVEQLEERIAQLSKELTELEA 761

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     259 QYEKMAEKNRK--DAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAETENRYC 336
Cdd:TIGR02168  762 EIEELEERLEEaeEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLE 841

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 4557701     337 V---QLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLE 389
Cdd:TIGR02168  842 DleeQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELE 897
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 138-383 7.16e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.06  E-value: 7.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     138 IEELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAY 217
Cdd:TIGR02168  693 IAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEE 772

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     218 L---KKNHEEEMNALRGQVGG-EINVEMDAAPGVDLSRILNEMRDQYEKMAEK---NRKDAEDWFFSkTEELNREVATNS 290
Cdd:TIGR02168  773 AeeeLAEAEAEIEELEAQIEQlKEELKALREALDELRAELTLLNEEAANLRERlesLERRIAATERR-LEDLEEQIEELS 851

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     291 ELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAETENRYCVQLSQIQgligSVEEQLAQLRCEMEQQNQEYKIL 370
Cdd:TIGR02168  852 EDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELR----ELESKRSELRRELEELREKLAQL 927

                          250
                   ....*....|...
gi 4557701     371 LDVKTRLEQEIAT 383
Cdd:TIGR02168  928 ELRLEGLEVRIDN 940
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 134-389 4.31e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 52.37  E-value: 4.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     134 YYRTIEELQNKI--LTATVDNANILLQIDNARLAADDfrTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENL 211
Cdd:TIGR02168  230 LVLRLEELREELeeLQEELKEAEEELEELTAELQELE--EKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQIL 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     212 KEELAYLKKNhEEEMNALRGQVGGEINVemDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWffsktEELNREVATNSE 291
Cdd:TIGR02168  308 RERLANLERQ-LEELEAQLEELESKLDE--LAEELAELEEKLEELKEELESLEAELEELEAEL-----EELESRLEELEE 379

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     292 LVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAETENR--------YCVQLSQIQGLIGSVEEQLAQLRCEMEQQ 363
Cdd:TIGR02168  380 QLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEieellkklEEAELKELQAELEELEEELEELQEELERL 459

                          250       260
                   ....*....|....*....|....*.
gi 4557701     364 NQEYKILLDVKTRLEQEIATYRRLLE 389
Cdd:TIGR02168  460 EEALEELREELEEAEQALDAAERELA 485
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 138-393 5.83e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.86  E-value: 5.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  138 IEELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAY 217
Cdd:COG1196 248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAE 327

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  218 LKKNHEEEMNALRGQVGGEINVEMDAApgvDLSRILNEMRDQYEKMAEKNRKDAEDWffsktEELNREVATNSELVQSGK 297
Cdd:COG1196 328 LEEELEELEEELEELEEELEEAEEELE---EAEAELAEAEEALLEAEAELAEAEEEL-----EELAEELLEALRAAAELA 399

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  298 SEISELRRTMQALEIELQSQLSMKASLEGNLAETENrycvQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRL 377
Cdd:COG1196 400 AQLEELEEAEEALLERLERLEEELEELEEALAELEE----EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALL 475

                       250
                ....*....|....*.
gi 4557701  378 EQEIATYRRLLEGEDA 393
Cdd:COG1196 476 EAALAELLEELAEAAA 491
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 174-382 4.47e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 4.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  174 ETEQALRlSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKK---NHEEEMNALRGQVGgEINVEMDAapgvdLS 250
Cdd:COG4942  24 EAEAELE-QLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARrirALEQELAALEAELA-ELEKEIAE-----LR 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  251 RILNEMRDQYEKMAEK----NRKDAEDWFFSKTE--ELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASL 324
Cdd:COG4942  97 AELEAQKEELAELLRAlyrlGRQPPLALLLSPEDflDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAEL 176

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4557701  325 EGNLAETENrycvQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIA 382
Cdd:COG4942 177 EALLAELEE----ERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 201-417 1.06e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 44.73  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701    201 RADLEMQIENLKEELAYLKKNHEEEMN-ALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAE------- 272
Cdd:pfam05557   4 LIESKARLSQLQNEKKQMELEHKRARIeLEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAElnrlkkk 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701    273 --DWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAETENRY------CVQLSQIQG 344
Cdd:pfam05557  84 ylEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKAseaeqlRQNLEKQQS 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4557701    345 LIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQeIATYRRLLEGEDAHLTQYKKepvTTRQVRTIVEEVQD 417
Cdd:pfam05557 164 SLAEAEQRIKELEFEIQSQEQDSEIVKNSKSELAR-IPELEKELERLREHNKHLNE---NIENKLLLKEEVED 232
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
190-389 1.92e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.85  E-value: 1.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  190 LRRVLDELTLARADLEMQIENLKEELAylkkNHEEEMNALRGQVGGeINVEMDAApgvDLSRILNEMRDQYEKmAEKNRK 269
Cdd:COG3206 166 LELRREEARKALEFLEEQLPELRKELE----EAEAALEEFRQKNGL-VDLSEEAK---LLLQQLSELESQLAE-ARAELA 236

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  270 DAEDWFFSKTEELNREVATNSELVQSgkSEISELRRTMQALEIELQSQLS--------------MKASLEGNLAETENRY 335
Cdd:COG3206 237 EAEARLAALRAQLGSGPDALPELLQS--PVIQQLRAQLAELEAELAELSArytpnhpdvialraQIAALRAQLQQEAQRI 314

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4557701  336 cvqLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVK---TRLEQEIATYRRLLE 389
Cdd:COG3206 315 ---LASLEAELEALQAREASLQAQLAQLEARLAELPELEaelRRLEREVEVARELYE 368
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 139-353 7.06e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 7.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     139 EELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAYL 218
Cdd:TIGR02168  312 ANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQL 391

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     219 kknhEEEMNALRGQVggEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKS 298
Cdd:TIGR02168  392 ----ELQIASLNNEI--ERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEE 465

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4557701     299 ---EISELRRTMQALEIELQSQLSMKASLEG--NLAETENRYCVQL----SQIQGLIGSVEEQL 353
Cdd:TIGR02168  466 lreELEEAEQALDAAERELAQLQARLDSLERlqENLEGFSEGVKALlknqSGLSGILGVLSELI 529
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 83-383 9.79e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 41.64  E-value: 9.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701      83 GEKATMQN----LNDRLASYLDKVRALEEANTEL-------EVKIRDWYQRQAPGparDYSQYYRTIEELQNKILTATVD 151
Cdd:pfam15921  486 AKKMTLESsertVSDLTASLQEKERAIEATNAEItklrsrvDLKLQELQHLKNEG---DHLRNVQTECEALKLQMAEKDK 562

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     152 NANILLQ-IDN-ARLAADDFRTKfETEQALRLSVEADINGLRRVLDELTLAR-------ADLEMQIENLKEELAYLKKNH 222
Cdd:pfam15921  563 VIEILRQqIENmTQLVGQHGRTA-GAMQVEKAQLEKEINDRRLELQEFKILKdkkdakiRELEARVSDLELEKVKLVNAG 641

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     223 EEEMNALRgqvggEINVEMDAAPG-VDLSRI-LNEMRDQYEKMAEKnrkdaedwFFSKTEELnrEVATNSELVQ--SGKS 298
Cdd:pfam15921  642 SERLRAVK-----DIKQERDQLLNeVKTSRNeLNSLSEDYEVLKRN--------FRNKSEEM--ETTTNKLKMQlkSAQS 706

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     299 EISELRRTMQALEielqsqlsmkaSLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLE 378
Cdd:pfam15921  707 ELEQTRNTLKSME-----------GSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLS 775


                   ....*
gi 4557701     379 QEIAT 383
Cdd:pfam15921  776 QELST 780
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 158-363 4.98e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.98  E-value: 4.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  158 QIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVG--- 234
Cdd:COG4942  35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRaly 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  235 -----GEINVEMDAAPGVDLSRILnemrdQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQA 309
Cdd:COG4942 115 rlgrqPPLALLLSPEDFLDAVRRL-----QYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAA 189

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 4557701  310 LEIELQSQLSMKASLEGNLAETENrycvQLSQIQGLIGSVEEQLAQLRCEMEQQ 363
Cdd:COG4942 190 LEALKAERQKLLARLEKELAELAA----ELAELQQEAEELEALIARLEAEAAAA 239
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 156-416 5.88e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 38.93  E-value: 5.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701    156 LLQIDNARLAADDFRTKFETEQALRLSVEADINglrrvLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGG 235
Cdd:pfam05483 159 LLKETCARSAEKTKKYEYEREETRQVYMDLNNN-----IEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKK 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701    236 EINVEMDAAPGV------------DLSRILNEMRDQYEKMAEKNRKDAEDW--FFSKTEELNREVATNSELVQSGKSEIS 301
Cdd:pfam05483 234 EINDKEKQVSLLliqitekenkmkDLTFLLEESRDKANQLEEKTKLQDENLkeLIEKKDHLTKELEDIKMSLQRSMSTQK 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701    302 ELRRTMQAL---------EIELQSQLSMKASLEGNLAETENRYCV-----QLSQIQGLIGSVEEQLAQLRCEMEQQNQEY 367
Cdd:pfam05483 314 ALEEDLQIAtkticqlteEKEAQMEELNKAKAAHSFVVTEFEATTcsleeLLRTEQQRLEKNEDQLKIITMELQKKSSEL 393

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 4557701    368 KILLDVKTRLEQEIATYRRLLeGEDAHLTQYKKepvttrQVRTIVEEVQ 416
Cdd:pfam05483 394 EEMTKFKNNKEVELEELKKIL-AEDEKLLDEKK------QFEKIAEELK 435
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 89-351 6.90e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 38.90  E-value: 6.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701      89 QNLNDRLASyldKVRALEEANTELEVKIRDWY---QRQAPGPARDYSQYYRTIEELQNKILTATVDNANILLQIDNARLA 165
Cdd:TIGR02169  261 SELEKRLEE---IEQLLEELNKKIKDLGEEEQlrvKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAE 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     166 ADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHE---EEMNALRGQVG--GEINVE 240
Cdd:TIGR02169  338 IEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEklkREINELKRELDrlQEELQR 417

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701     241 MDAapgvDLSRILNEMRDQYEKMAE-KNRKDAEDwffSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLS 319
Cdd:TIGR02169  418 LSE----ELADLNAAIAGIEAKINElEEEKEDKA---LEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQR 490

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 4557701     320 MKASLEGNL--AETENRYCVQL-----SQIQGLIGSVEE 351
Cdd:TIGR02169  491 ELAEAEAQAraSEERVRGGRAVeevlkASIQGVHGTVAQ 529
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
85-319 8.87e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 38.46  E-value: 8.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701   85 KATMQNLNDRLASYLDKVRALEEAntelevkIRDwYQRQAP--GPARDYSQYYRTIEELQNKILTATVDnanilLQIDNA 162
Cdd:COG3206 174 RKALEFLEEQLPELRKELEEAEAA-------LEE-FRQKNGlvDLSEEAKLLLQQLSELESQLAEARAE-----LAEAEA 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  163 RLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEM-------QIENLKEELAYLKKNHEEEMNALRGQVgg 235
Cdd:COG3206 241 RLAALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSArytpnhpDVIALRAQIAALRAQLQQEAQRILASL-- 318

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557701  236 EINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRkdaedwffsKTEELNREVATNSELVQSgkseiseLRRTMQALEIELQ 315
Cdd:COG3206 319 EAELEALQAREASLQAQLAQLEARLAELPELEA---------ELRRLEREVEVARELYES-------LLQRLEEARLAEA 382


                ....
gi 4557701  316 SQLS 319
Cdd:COG3206 383 LTVG 386
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH