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Conserved domains on  [gi|2462545587|ref|XP_054234633|]
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golgin subfamily A member 8T isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GOLGA2L5 super family cl25923
Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein ...
 75-308 2.26e-37

Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes.


The actual alignment was detected with superfamily member pfam15070:

Pssm-ID: 464485 [Multi-domain]  Cd Length: 521  Bit Score: 143.67  E-value: 2.26e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  75 QLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVP-- 152
Cdd:pfam15070   1 QLMESLKQLQTERDQYAENLKEEGAVWQQKMQQLSEQVRTLREEKERSVSQVQELETSLAELKNQAAVPPAEEEQPPAgp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 153 SEVE------LQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSL------------- 213
Cdd:pfam15070  81 SEEEqrlqeeAEQLQKELEALAGQLQAQVQDNEQLSRLNQEQEQRLLELERAAERWGEQAEDRKQILedmqsdratisra 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 214 --------QQLAKPQSVFEEPNNEN---KNALQLEQQVK--------ELQEKLGE------------------------- 249
Cdd:pfam15070 161 lsqnrelkEQLAELQNGFVKLTNENmelTSALQSEQHVKkelakklgQLQEELGElketlelksqeaqslqeqrdqylah 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 250 ------------------------------------------------------EHLEAASQQNQQLTAQLSLMALPGEG 275
Cdd:pfam15070 241 lqqyvaayqqlasekeelhkqyllqtqlmdrlqheevqgkvaaemarqelqetqERLEALTQQNQQLQAQLSLLANPGEG 320

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2462545587 276 HGGEHlDSEGEEAPQPMPSVPEDLESREAMSSF 308
Cdd:pfam15070 321 DGLES-EEEEEEAPRPSLSIPEDFESREAMVAF 352
GM130_C pfam19046
GM130 C-terminal binding motif; This entry represents the C-terminal motif from the GM130 ...
 441-480 1.00e-14

GM130 C-terminal binding motif; This entry represents the C-terminal motif from the GM130 protein that is bound by the GRASP65 PDZ domain pfam04495.


:

Pssm-ID: 465957  Cd Length: 46  Bit Score: 68.18  E-value: 1.00e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462545587 441 PLLDKPTAQPIV------QDHQEHPGLGSNCCVPFLCWAWLPRRRR 480
Cdd:pfam19046   1 SPPENPTAQQIMqllpeiQNPQEHPGLGSNPCIPFFYRADENDEVK 46
 
Name Accession Description Interval E-value
GOLGA2L5 pfam15070
Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein ...
 75-308 2.26e-37

Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes.


Pssm-ID: 464485 [Multi-domain]  Cd Length: 521  Bit Score: 143.67  E-value: 2.26e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  75 QLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVP-- 152
Cdd:pfam15070   1 QLMESLKQLQTERDQYAENLKEEGAVWQQKMQQLSEQVRTLREEKERSVSQVQELETSLAELKNQAAVPPAEEEQPPAgp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 153 SEVE------LQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSL------------- 213
Cdd:pfam15070  81 SEEEqrlqeeAEQLQKELEALAGQLQAQVQDNEQLSRLNQEQEQRLLELERAAERWGEQAEDRKQILedmqsdratisra 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 214 --------QQLAKPQSVFEEPNNEN---KNALQLEQQVK--------ELQEKLGE------------------------- 249
Cdd:pfam15070 161 lsqnrelkEQLAELQNGFVKLTNENmelTSALQSEQHVKkelakklgQLQEELGElketlelksqeaqslqeqrdqylah 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 250 ------------------------------------------------------EHLEAASQQNQQLTAQLSLMALPGEG 275
Cdd:pfam15070 241 lqqyvaayqqlasekeelhkqyllqtqlmdrlqheevqgkvaaemarqelqetqERLEALTQQNQQLQAQLSLLANPGEG 320

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2462545587 276 HGGEHlDSEGEEAPQPMPSVPEDLESREAMSSF 308
Cdd:pfam15070 321 DGLES-EEEEEEAPRPSLSIPEDFESREAMVAF 352
GM130_C pfam19046
GM130 C-terminal binding motif; This entry represents the C-terminal motif from the GM130 ...
 441-480 1.00e-14

GM130 C-terminal binding motif; This entry represents the C-terminal motif from the GM130 protein that is bound by the GRASP65 PDZ domain pfam04495.


Pssm-ID: 465957  Cd Length: 46  Bit Score: 68.18  E-value: 1.00e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462545587 441 PLLDKPTAQPIV------QDHQEHPGLGSNCCVPFLCWAWLPRRRR 480
Cdd:pfam19046   1 SPPENPTAQQIMqllpeiQNPQEHPGLGSNPCIPFFYRADENDEVK 46
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 9-268 3.85e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.10  E-value: 3.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587   9 EEKSKDLAVRLQHSLQRKGELESVLSNVMATQKKKANQLSSRSKARTEW---KLEQSMREETLLKVQLTQLKESFQQVQL 85
Cdd:COG1196   221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELeelRLELEELELELEEAQAEEYELLAELARL 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  86 ERDEysEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELE 165
Cdd:COG1196   301 EQDI--ARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE 378

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 166 R-----VAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKNALQLEQQV 240
Cdd:COG1196   379 EeleelAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE 458

                         250       260
                  ....*....|....*....|....*...
gi 2462545587 241 KELQEKLGEEHLEAASQQNQQLTAQLSL 268
Cdd:COG1196   459 EALLELLAELLEEAALLEAALAELLEEL 486
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-290 4.72e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 52.75  E-value: 4.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587    2 KRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSNV--MATQKKKANQLSSRSKARTEWKLEQSMREETLLKVQLTQLKES 79
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELeeELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKE 755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587   80 FQQVQLERDEYSEHLKGERARWQQRmrkmSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQH 159
Cdd:TIGR02168  756 LTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLER 831

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  160 LRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKP-----QSVFEEPNNENKNAL 234
Cdd:TIGR02168  832 RIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALlrselEELSEELRELESKRS 911

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462545587  235 QLEQQVKELQEKLG--EEHLEAASQQNQQLTAQLS-LMALPGEGHGGEHLDSEGEEAPQ 290
Cdd:TIGR02168  912 ELRRELEELREKLAqlELRLEGLEVRIDNLQERLSeEYSLTLEEAEALENKIEDDEEEA 970
PRK11281 PRK11281
mechanosensitive channel MscK;
65-265 8.86e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.82  E-value: 8.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587   65 EETLLKVQLTQLKESFQQVQLERDEySEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRR------VEELERSLSKLKN 138
Cdd:PRK11281    57 EDKLVQQDLEQTLALLDKIDRQKEE-TEQLKQQLAQAPAKLRQAQAELEALKDDNDEETREtlstlsLRQLESRLAQTLD 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  139 QMAEPLPPEPPAVPSEVELQhlrKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQ--------EERIQEQH 210
Cdd:PRK11281   136 QLQNAQNDLAEYNSQLVSLQ---TQPERAQAALYANSQRLQQIRNLLKGGKVGGKALRPSQRVLlqaeqallNAQNDLQR 212

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462545587  211 KSLQQLAKPQSVFEEPNNE-NKNALQLEQQVKELQEKLGEEHLEAASQQNQQLTAQ 265
Cdd:PRK11281   213 KSLEGNTQLQDLLQKQRDYlTARIQRLEHQLQLLQEAINSKRLTLSEKTVQEAQSQ 268
 
Name Accession Description Interval E-value
GOLGA2L5 pfam15070
Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein ...
 75-308 2.26e-37

Putative golgin subfamily A member 2-like protein 5; The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes.


Pssm-ID: 464485 [Multi-domain]  Cd Length: 521  Bit Score: 143.67  E-value: 2.26e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  75 QLKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVP-- 152
Cdd:pfam15070   1 QLMESLKQLQTERDQYAENLKEEGAVWQQKMQQLSEQVRTLREEKERSVSQVQELETSLAELKNQAAVPPAEEEQPPAgp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 153 SEVE------LQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSL------------- 213
Cdd:pfam15070  81 SEEEqrlqeeAEQLQKELEALAGQLQAQVQDNEQLSRLNQEQEQRLLELERAAERWGEQAEDRKQILedmqsdratisra 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 214 --------QQLAKPQSVFEEPNNEN---KNALQLEQQVK--------ELQEKLGE------------------------- 249
Cdd:pfam15070 161 lsqnrelkEQLAELQNGFVKLTNENmelTSALQSEQHVKkelakklgQLQEELGElketlelksqeaqslqeqrdqylah 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 250 ------------------------------------------------------EHLEAASQQNQQLTAQLSLMALPGEG 275
Cdd:pfam15070 241 lqqyvaayqqlasekeelhkqyllqtqlmdrlqheevqgkvaaemarqelqetqERLEALTQQNQQLQAQLSLLANPGEG 320

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2462545587 276 HGGEHlDSEGEEAPQPMPSVPEDLESREAMSSF 308
Cdd:pfam15070 321 DGLES-EEEEEEAPRPSLSIPEDFESREAMVAF 352
GM130_C pfam19046
GM130 C-terminal binding motif; This entry represents the C-terminal motif from the GM130 ...
 441-480 1.00e-14

GM130 C-terminal binding motif; This entry represents the C-terminal motif from the GM130 protein that is bound by the GRASP65 PDZ domain pfam04495.


Pssm-ID: 465957  Cd Length: 46  Bit Score: 68.18  E-value: 1.00e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462545587 441 PLLDKPTAQPIV------QDHQEHPGLGSNCCVPFLCWAWLPRRRR 480
Cdd:pfam19046   1 SPPENPTAQQIMqllpeiQNPQEHPGLGSNPCIPFFYRADENDEVK 46
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 9-268 3.85e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.10  E-value: 3.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587   9 EEKSKDLAVRLQHSLQRKGELESVLSNVMATQKKKANQLSSRSKARTEW---KLEQSMREETLLKVQLTQLKESFQQVQL 85
Cdd:COG1196   221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELeelRLELEELELELEEAQAEEYELLAELARL 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  86 ERDEysEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELE 165
Cdd:COG1196   301 EQDI--ARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE 378

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 166 R-----VAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKNALQLEQQV 240
Cdd:COG1196   379 EeleelAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE 458

                         250       260
                  ....*....|....*....|....*...
gi 2462545587 241 KELQEKLGEEHLEAASQQNQQLTAQLSL 268
Cdd:COG1196   459 EALLELLAELLEEAALLEAALAELLEEL 486
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-290 4.72e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 52.75  E-value: 4.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587    2 KRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSNV--MATQKKKANQLSSRSKARTEWKLEQSMREETLLKVQLTQLKES 79
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELeeELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKE 755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587   80 FQQVQLERDEYSEHLKGERARWQQRmrkmSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQH 159
Cdd:TIGR02168  756 LTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLER 831

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  160 LRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKP-----QSVFEEPNNENKNAL 234
Cdd:TIGR02168  832 RIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALlrselEELSEELRELESKRS 911

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462545587  235 QLEQQVKELQEKLG--EEHLEAASQQNQQLTAQLS-LMALPGEGHGGEHLDSEGEEAPQ 290
Cdd:TIGR02168  912 ELRRELEELREKLAqlELRLEGLEVRIDNLQERLSeEYSLTLEEAEALENKIEDDEEEA 970
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 40-304 7.98e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.98  E-value: 7.98e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587   40 QKKKANQLSSRSKARTEWKLEQSMREETLLKVQLTQLKESFQQVQLERDEYSEHLKGERARWQQ---RMRKMSQEICTLK 116
Cdd:TIGR02168  208 QAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEElrlEVSELEEEIEELQ 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  117 KEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAvpsEVELQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQE 196
Cdd:TIGR02168  288 KELYALANEISRLEQQKQILRERLANLERQLEEL---EAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELE 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  197 ERLRKQEERIQEQHKSLQQLAKpqSVFEEPNNENKNALQLEQQVKELQEKlgEEHLEAASQQNQQLTAQLSLMALPGEGH 276
Cdd:TIGR02168  365 AELEELESRLEELEEQLETLRS--KVAQLELQIASLNNEIERLEARLERL--EDRRERLQQEIEELLKKLEEAELKELQA 440

                          250       260
                   ....*....|....*....|....*...
gi 2462545587  277 GGEHLDSEGEEAPQPMPSVPEDLESREA 304
Cdd:TIGR02168  441 ELEELEEELEELQEELERLEEALEELRE 468
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 9-265 9.98e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.39  E-value: 9.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587   9 EEKSKDLAVRLQHSLQRKGELEsvlsnvmATQKKKANQLSSRSKARTEWKLEQSMREETLLKVQLtQLKESFQQVQLERD 88
Cdd:COG1196   301 EQDIARLEERRRELEERLEELE-------EELAELEEELEELEEELEELEEELEEAEEELEEAEA-ELAEAEEALLEAEA 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  89 EYSEHLKGERARWQQRMRKMSQEIcTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVA 168
Cdd:COG1196   373 ELAEAEEELEELAEELLEALRAAA-ELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE 451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 169 GELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKN---------ALQLEQQ 239
Cdd:COG1196   452 AELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLlaglrglagAVAVLIG 531

                         250       260
                  ....*....|....*....|....*.
gi 2462545587 240 VKELQEKLGEEHLEAASQQNQQLTAQ 265
Cdd:COG1196   532 VEAAYEAALEAALAAALQNIVVEDDE 557
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 6-324 2.69e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.98  E-value: 2.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587    6 RYFEEKSKDLAVRLQhSLQRkgELESVLSNVmATQKKKANQLSSRSKARTEwKLEQSMREETLLKVQLTQLKEsfQQVQL 85
Cdd:TIGR02169  670 RSEPAELQRLRERLE-GLKR--ELSSLQSEL-RRIENRLDELSQELSDASR-KIGEIEKEIEQLEQEEEKLKE--RLEEL 742

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587   86 ERDeysehlkgerarwqqrMRKMSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEV--ELQHLRKE 163
Cdd:TIGR02169  743 EED----------------LSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIqaELSKLEEE 806

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  164 LERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERI----QEQHKSLQQLAKPQSVFEEPNNE---------- 229
Cdd:TIGR02169  807 VSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIksieKEIENLNGKKEELEEELEELEAAlrdlesrlgd 886

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  230 -NKNALQLEQQVKELQEKLGE--EHLEAASQQNQQLTAQLSlmALPGEGHGGEHLDSEGEEAPQPMPSVPEDLESREAMS 306
Cdd:TIGR02169  887 lKKERDELEAQLRELERKIEEleAQIEKKRKRLSELKAKLE--ALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVE 964

                          330       340       350
                   ....*....|....*....|....*....|
gi 2462545587  307 SFMDHL------------KEKADLSELVKK 324
Cdd:TIGR02169  965 EEIRALepvnmlaiqeyeEVLKRLDELKEK 994
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 9-266 4.63e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 4.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587    9 EEKSKDLAVRLQHSLQRKGELESVLSNVMATQKKKANqlSSRSKARTEWKLEQSMREETLLKVQLTQLKESFQQVQLERD 88
Cdd:TIGR02168  221 ELRELELALLVLRLEELREELEELQEELKEAEEELEE--LTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEIS 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587   89 EysehLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVA 168
Cdd:TIGR02168  299 R----LEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRL 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  169 GELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKNALQLEQQVKELQEKlg 248
Cdd:TIGR02168  375 EELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEEL-- 452

                          250
                   ....*....|....*...
gi 2462545587  249 EEHLEAASQQNQQLTAQL 266
Cdd:TIGR02168  453 QEELERLEEALEELREEL 470
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 69-268 1.02e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  69 LKVQLTQLK------ESFQQVQLERDEYSEHLKGERARW-QQRMRKMSQEICTLKKEKQQDMRRVEELERSLSKLKNQMA 141
Cdd:COG1196   198 LERQLEPLErqaekaERYRELKEELKELEAELLLLKLRElEAELEELEAELEELEAELEELEAELAELEAELEELRLELE 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 142 EPLPPEPPAVPsevELQHLRKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKpqs 221
Cdd:COG1196   278 ELELELEEAQA---EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEE--- 351

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2462545587 222 VFEEPNNENKNALQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSL 268
Cdd:COG1196   352 ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
PRK11281 PRK11281
mechanosensitive channel MscK;
65-265 8.86e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.82  E-value: 8.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587   65 EETLLKVQLTQLKESFQQVQLERDEySEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRR------VEELERSLSKLKN 138
Cdd:PRK11281    57 EDKLVQQDLEQTLALLDKIDRQKEE-TEQLKQQLAQAPAKLRQAQAELEALKDDNDEETREtlstlsLRQLESRLAQTLD 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  139 QMAEPLPPEPPAVPSEVELQhlrKELERVAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQ--------EERIQEQH 210
Cdd:PRK11281   136 QLQNAQNDLAEYNSQLVSLQ---TQPERAQAALYANSQRLQQIRNLLKGGKVGGKALRPSQRVLlqaeqallNAQNDLQR 212

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462545587  211 KSLQQLAKPQSVFEEPNNE-NKNALQLEQQVKELQEKLGEEHLEAASQQNQQLTAQ 265
Cdd:PRK11281   213 KSLEGNTQLQDLLQKQRDYlTARIQRLEHQLQLLQEAINSKRLTLSEKTVQEAQSQ 268
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
18-253 1.97e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 40.82  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  18 RLQHSLQRKGELESVLSNVMATQKKKANQLSSRSKARTEWKLEQSMREETLLKvqLTQLKESFQQVQLERDEYSEHLKGE 97
Cdd:PRK03918  180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKE--LEELKEEIEELEKELESLEGSKRKL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  98 RARWQQRMRKMsqeictlkKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVKK 177
Cdd:PRK03918  258 EEKIRELEERI--------EELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEER 329

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462545587 178 NQRISllnqrqeeriqeqeerlrKQEERIQEQHKSLQQLAKPQSVFEEPNNENKNALQLEQQVKELQEKLGEEHLE 253
Cdd:PRK03918  330 IKELE------------------EKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPE 387
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
41-271 2.28e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  41 KKKANQLSSRSKARTEWKLEQSMREETLLKvQLTQLKESFQQVQLERDEYS---EHLKGERARWQQRMRKMSQEIctlkk 117
Cdd:COG4717    52 EKEADELFKPQGRKPELNLKELKELEEELK-EAEEKEEEYAELQEELEELEeelEELEAELEELREELEKLEKLL----- 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 118 EKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQAQVkknQRISLLNQRQEERIQEQEE 197
Cdd:COG4717   126 QLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELL---EQLSLATEEELQDLAEELE 202

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462545587 198 RLRKQEERIQEQHKSLQQLAKpqsvfeepnnenknalQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLSLMAL 271
Cdd:COG4717   203 ELQQRLAELEEELEEAQEELE----------------ELEEELEQLENELEAAALEERLKEARLLLLIAAALLA 260
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 23-265 2.51e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.49  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  23 LQRKGELESVLSNVMATQKKKANQLSSRSKARTEWKLEQSMREETLLKVQLTQLKESFQQVQLERDEYSEHLKGERARWQ 102
Cdd:pfam17380 312 VERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKN 391

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 103 QRMRKMSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVElqhlrKELERVAGELQAQVKKNQRIs 182
Cdd:pfam17380 392 ERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERA-----REMERVRLEEQERQQQVERL- 465

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587 183 llnqrqeerIQEQEERLRKQEERIQEQHKSLQQLAKPQSVFEEPNNENKNALQLEQQVKELQEKLGEEHLEAASQQNQQL 262
Cdd:pfam17380 466 ---------RQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRR 536


                  ...
gi 2462545587 263 TAQ 265
Cdd:pfam17380 537 EAE 539
PTZ00121 PTZ00121
MAEBL; Provisional
 9-230 5.55e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 5.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587    9 EEKSKDLAVRLQHSLQR--KGELESVLSNVMATQKKKANQL----SSRSKARTEWKLEQSMREETLLKVQLTQLKESFQQ 82
Cdd:PTZ00121  1572 AEEDKNMALRKAEEAKKaeEARIEEVMKLYEEEKKMKAEEAkkaeEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEE 1651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587   83 V------------QLERDEYSEHLKGERARWQQRMRKMSQEictLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPA 150
Cdd:PTZ00121  1652 LkkaeeenkikaaEEAKKAEEDKKKAEEAKKAEEDEKKAAE---ALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEEN 1728

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  151 VPSEVELQHLRKELERVAGELQ---------AQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKPQS 221
Cdd:PTZ00121  1729 KIKAEEAKKEAEEDKKKAEEAKkdeeekkkiAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFA 1808


                   ....*....
gi 2462545587  222 VFEEPNNEN 230
Cdd:PTZ00121  1809 NIIEGGKEG 1817
PTZ00121 PTZ00121
MAEBL; Provisional
 9-353 9.19e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 9.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587    9 EEKSKDLAVRLQHSLQRKGELESVLSNVM--ATQKKKANQLSSRSKARTEWKLEQSMREETLLKVQLTQLKESFQQVQLE 86
Cdd:PTZ00121  1435 EAKKKAEEAKKADEAKKKAEEAKKAEEAKkkAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADE 1514

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587   87 RDEYSEHLKGERARWQQRMRKMSQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELqhLRKELER 166
Cdd:PTZ00121  1515 AKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE--AKKAEEA 1592

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  167 VAGELQAQVKKNQRISLLNQRQEERIQEQEERLRKQEERIQEQHKSLQQLAKPQSVFEE-PNNENKNALQLEQQV-KELQ 244
Cdd:PTZ00121  1593 RIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElKKAEEENKIKAAEEAkKAEE 1672

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545587  245 EKLGEEHLEAASQQNQQLTAQLSLMAlpGEGHGGEHLDSEGEEAPQPMPSVPEDLESR----EAMSSFMDHLKEKADLSE 320
Cdd:PTZ00121  1673 DKKKAEEAKKAEEDEKKAAEALKKEA--EEAKKAEELKKKEAEEKKKAEELKKAEEENkikaEEAKKEAEEDKKKAEEAK 1750

                          330       340       350
                   ....*....|....*....|....*....|...
gi 2462545587  321 LVKKELCFIHHWRDRRHQKTHHLLSEPGGCAKD 353
Cdd:PTZ00121  1751 KDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE 1783
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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