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Fanconi anemia group I protein isoform X2 [Homo sapiens]
Protein Classification
FANCI_S1-cap and FANCI domain-containing protein ( domain architecture ID 10631061 )
FANCI_S1-cap and FANCI domain-containing protein
List of domain hits
Name
Accession
Description
Interval
E-value
FANCI
cd11720 Fanconi anemia I protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
43-1276
0e+00
Fanconi anemia I protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCI may function as a molecular switch to turn on the FA pathway.
Pssm-ID: 212594 [Multi-domain]
Cd Length: 1202
Bit Score: 1294.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 43 AGA LLRAI FK G SP CS EE a GTLR R R K IYTCC I Q L VE S GD L QKEI A SE II GL L M LE AHHF PG PL LVEL ANEFISAV R E G SLV 122
Cdd:cd11720 3 TIK LLRAI LL G LS CS PD - SASK R L K VVKSV I N L LN S AE L STKV A FD II SR L L LE LPKL PG EQ LVEL VELCVDGI R N G DNS 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 123 NG KSLE LLP I IL T AL ATK KE n LA Y GK G V L S G E E C K K Q L IN TL CS GR W DQQYVIQ LTSMF K D VP L TA EE VE FVVEK ALSMF 202
Cdd:cd11720 82 NG SWKD LLP T IL S AL SEE KE - IL Y EG G E L T G A E Y K S Q I IN SI CS SK W QPNILTS LTSMF R D LS L SK EE LN FVVEK LCRAL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 203 SKMN LQE I PPLVYQLLVL S SKG SRKS VLEG IIAF F SA L DKQHNEEQSGD --- E LLDVV T VPSG E L R HV EGT II LHI V FA I 279
Cdd:cd11720 161 KELD LQE L PPLVYQLLVL C SKG DKLL VLEG LQKY F DK L YYKRLLSDANS sst E DDEIE T SSPK E V R EA EGT VL LHI N FA A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 280 K L D Y ELG R E LV K H LK VG Q QGD s NNN L S PFS IAL LLS VT RI Q RF QD QV L D L LKT SV V K SFK DLQ L L Q G S KF L QN L V - P HRS 358
Cdd:cd11720 241 K Q D H ELG K E FL K L LK SV Q RVP - EKA L T PFS LSV LLS MS RI N RF EE QV F D F LKT AI V R SFK EKE L Q Q N S AW L RE L L l P QVK 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 359 Y V STMI L E VVKNSV HSW DHVT Q GLV E LGFIL MD SYGPK KV L D gktietsp S L S RM P NQH A CK LG AN ILL ET FK I HE MI R Q 438
Cdd:cd11720 320 D V EKIL L R VVKNSV SGR DHVT P GLV N LGFIL LE SYGPK AS L E -------- S G S KT P APK A WQ LG IK ILL KI FK K HE IA R S 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 439 EILEQ VL NR V VT RA S s P I S HFL D L LS NI V MY APL VLQSCS SK V TE AF DYL S F L P LQTVQ RLLKA V QPLLK V S M S M RD C LI 518
Cdd:cd11720 392 EILEQ LK NR I VT LP S - P V S QYI D C LS YL V QS APL LMLEHV SK I TE LL DYL T F I P GSSAM RLLKA I QPLLK I S R S L RD S LI 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 519 LVLRKA M F ANQLDA R KS AV A GFLLLLKN F K V L G SL S SSQ C S QSL S VS Q VHV DVHS H Y - N S VA NE TF CLEI MDS LRRCL S Q 597
Cdd:cd11720 471 LVLRKA L F SRETET R QM AV T GFLLLLKN L K L L S SL G SSQ S S SAS S ST Q ASI DVHS Q Y s S S ES NE SL CLEI LGL LRRCL T Q 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 598 QA D VRLMLYEG F Y D V LR RN SQ LA NS V MQT LL SQL K Q F Y E PKP D L L P PLKLE A C IL TQGD K I S LQEPL DY L LC CIQHCL AW 677
Cdd:cd11720 551 QA E VRLMLYEG L Y R V VL RN PE LA PH V LDL LL PHF K S F F E EDE D V L L PLKLE S C VT TQGD D I V LQEPL GH L IF CIQHCL LL 630
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 678 Y K ntviplq Q GEEEEEEEE A FYEDLDDI LESI TN RMIK S ELEDFELDKSADFS QST S I G I K NNIC A F L VM G VC EVLIEY N 757
Cdd:cd11720 631 S K ------- Q NNSGRPDAA A ALLEESLM LESI CK RMIK V ELEDFELDKSADFS VNS S V G Q K KLLN A L L LL G IY EVLIEY I 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 758 F S I SSF - SKN RFED IL S LF MC Y KK L S D IL nekagkaktkman KTSDS LL --- S MKFVSSLL T A L F RS SN EFMRY AVN V A L 833
Cdd:cd11720 704 F N I WNK v SKN ACKE IL G LF KL Y ES L L D LV ------------- SKLLT LL fdt S VQYATEDQ T S L L RS NR EFMRY ILS V C L 770
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 834 QK V Q Q LK E T GHVS G pd GQ NPEK IFQNLCDIT R VL LW R YT S IP T SV eesg KK EK GK S I S LL C LE GLQK I FSA V Q Q F Y QP K I 913
Cdd:cd11720 771 QK L Q S LK N T PDYD G -- GQ HSKR IFQNLCDIT K VL YL R KI S KL T EL ---- KK DF GK Q I A LL A LE CFLE I LNV V L Q L Y PS K L 844
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 914 QQ FL RAL DV T D kegee REDADVSVTQRTA FQIR Q F Q RSL LN LLS SQ E - EDF N SKE ALL L VTV L TS LS KL L E P S S P Q FV QM 992
Cdd:cd11720 845 ED FL SVI DV E D ----- GGGEKSTIDEQLH FQIR H F I RSL MK LLS TE E e EDF V SKE VVI L IEI L SV LS DK L P P N S T Q AK QM 919
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 993 L S W TS KICKEN SR ED ALFC K SLMN LL F SLHV SYKSPVI LL RDLS Q DIHGH LGDID Q D V E V E kt N H FAIVNLR T A A PT V CL 1072
Cdd:cd11720 920 L T W LL KICKEN EL ED SSVA K AVLT LL L SLHV RTQEYLE LL DEVA Q ELCAV LGDID E D E E T E -- S H KLKIINE T T A ES V LT 997
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 1073 L V L SQAE KVL EE VDWLI TK LK GQVSQET L SE E A S S Q ATLPNQPV E KA I IM QL GTLL T FFH ELV Q TA L P S GSC V D T LLK D L 1152
Cdd:cd11720 998 L L L ASLD KVL DD VDWLI KR LK AELNVDQ L PG E D S E Q SQGNLKSI E RS I CE QL YHIA T VLT ELV N TA I P P GSC A D A LLK L L 1077
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 1153 C K M Y T TL TA L VRYYLQVCQSSGGI P KN - M EKLV K L S G SH LTP LC Y S FI S YV QN ks KSLNYTGE KK E K P A AVATAMARV LR 1231
Cdd:cd11720 1078 I K L Y K TL SN L TKHFIARSTKNPVF P SA k F EKLV E L A G KQ LTP NI Y N FI T YV EE -- NQSEQDSK KK K K K A KSKVQRNKI LR 1155
1210 1220 1230 1240
....*....|....*....|....*....|....*....|....*
gi 2462545024 1232 ETK P IP N LI F AIEQ Y EKFLI H LSKK S KVNLM QH MKLST S RDF K IK 1276
Cdd:cd11720 1156 ETK L IP K LI Y AIEQ F EKFLI Q LSKK T KVNLM RY MKLST T RDF R IK 1200
FANCI_S1-cap
pfam14674 FANCI solenoid 1 cap; This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I ...
1-53
3.14e-22
FANCI solenoid 1 cap; This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I protein.
Pssm-ID: 434117
Cd Length: 53
Bit Score: 90.81
E-value: 3.14e-22
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2462545024 1 MDQKILSLAAE KTADK LQ E FLQTL R E GD LT N L LQ N Q A V KGK VA GALLRAIFKG 53
Cdd:pfam14674 1 MDQKILSLAAE DSTEE LQ K FLQTL T E DE LT E L IT N S A L KGK DV GALLRAIFKG 53
Name
Accession
Description
Interval
E-value
FANCI
cd11720 Fanconi anemia I protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
43-1276
0e+00
Fanconi anemia I protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCI may function as a molecular switch to turn on the FA pathway.
Pssm-ID: 212594 [Multi-domain]
Cd Length: 1202
Bit Score: 1294.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 43 AGA LLRAI FK G SP CS EE a GTLR R R K IYTCC I Q L VE S GD L QKEI A SE II GL L M LE AHHF PG PL LVEL ANEFISAV R E G SLV 122
Cdd:cd11720 3 TIK LLRAI LL G LS CS PD - SASK R L K VVKSV I N L LN S AE L STKV A FD II SR L L LE LPKL PG EQ LVEL VELCVDGI R N G DNS 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 123 NG KSLE LLP I IL T AL ATK KE n LA Y GK G V L S G E E C K K Q L IN TL CS GR W DQQYVIQ LTSMF K D VP L TA EE VE FVVEK ALSMF 202
Cdd:cd11720 82 NG SWKD LLP T IL S AL SEE KE - IL Y EG G E L T G A E Y K S Q I IN SI CS SK W QPNILTS LTSMF R D LS L SK EE LN FVVEK LCRAL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 203 SKMN LQE I PPLVYQLLVL S SKG SRKS VLEG IIAF F SA L DKQHNEEQSGD --- E LLDVV T VPSG E L R HV EGT II LHI V FA I 279
Cdd:cd11720 161 KELD LQE L PPLVYQLLVL C SKG DKLL VLEG LQKY F DK L YYKRLLSDANS sst E DDEIE T SSPK E V R EA EGT VL LHI N FA A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 280 K L D Y ELG R E LV K H LK VG Q QGD s NNN L S PFS IAL LLS VT RI Q RF QD QV L D L LKT SV V K SFK DLQ L L Q G S KF L QN L V - P HRS 358
Cdd:cd11720 241 K Q D H ELG K E FL K L LK SV Q RVP - EKA L T PFS LSV LLS MS RI N RF EE QV F D F LKT AI V R SFK EKE L Q Q N S AW L RE L L l P QVK 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 359 Y V STMI L E VVKNSV HSW DHVT Q GLV E LGFIL MD SYGPK KV L D gktietsp S L S RM P NQH A CK LG AN ILL ET FK I HE MI R Q 438
Cdd:cd11720 320 D V EKIL L R VVKNSV SGR DHVT P GLV N LGFIL LE SYGPK AS L E -------- S G S KT P APK A WQ LG IK ILL KI FK K HE IA R S 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 439 EILEQ VL NR V VT RA S s P I S HFL D L LS NI V MY APL VLQSCS SK V TE AF DYL S F L P LQTVQ RLLKA V QPLLK V S M S M RD C LI 518
Cdd:cd11720 392 EILEQ LK NR I VT LP S - P V S QYI D C LS YL V QS APL LMLEHV SK I TE LL DYL T F I P GSSAM RLLKA I QPLLK I S R S L RD S LI 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 519 LVLRKA M F ANQLDA R KS AV A GFLLLLKN F K V L G SL S SSQ C S QSL S VS Q VHV DVHS H Y - N S VA NE TF CLEI MDS LRRCL S Q 597
Cdd:cd11720 471 LVLRKA L F SRETET R QM AV T GFLLLLKN L K L L S SL G SSQ S S SAS S ST Q ASI DVHS Q Y s S S ES NE SL CLEI LGL LRRCL T Q 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 598 QA D VRLMLYEG F Y D V LR RN SQ LA NS V MQT LL SQL K Q F Y E PKP D L L P PLKLE A C IL TQGD K I S LQEPL DY L LC CIQHCL AW 677
Cdd:cd11720 551 QA E VRLMLYEG L Y R V VL RN PE LA PH V LDL LL PHF K S F F E EDE D V L L PLKLE S C VT TQGD D I V LQEPL GH L IF CIQHCL LL 630
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 678 Y K ntviplq Q GEEEEEEEE A FYEDLDDI LESI TN RMIK S ELEDFELDKSADFS QST S I G I K NNIC A F L VM G VC EVLIEY N 757
Cdd:cd11720 631 S K ------- Q NNSGRPDAA A ALLEESLM LESI CK RMIK V ELEDFELDKSADFS VNS S V G Q K KLLN A L L LL G IY EVLIEY I 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 758 F S I SSF - SKN RFED IL S LF MC Y KK L S D IL nekagkaktkman KTSDS LL --- S MKFVSSLL T A L F RS SN EFMRY AVN V A L 833
Cdd:cd11720 704 F N I WNK v SKN ACKE IL G LF KL Y ES L L D LV ------------- SKLLT LL fdt S VQYATEDQ T S L L RS NR EFMRY ILS V C L 770
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 834 QK V Q Q LK E T GHVS G pd GQ NPEK IFQNLCDIT R VL LW R YT S IP T SV eesg KK EK GK S I S LL C LE GLQK I FSA V Q Q F Y QP K I 913
Cdd:cd11720 771 QK L Q S LK N T PDYD G -- GQ HSKR IFQNLCDIT K VL YL R KI S KL T EL ---- KK DF GK Q I A LL A LE CFLE I LNV V L Q L Y PS K L 844
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 914 QQ FL RAL DV T D kegee REDADVSVTQRTA FQIR Q F Q RSL LN LLS SQ E - EDF N SKE ALL L VTV L TS LS KL L E P S S P Q FV QM 992
Cdd:cd11720 845 ED FL SVI DV E D ----- GGGEKSTIDEQLH FQIR H F I RSL MK LLS TE E e EDF V SKE VVI L IEI L SV LS DK L P P N S T Q AK QM 919
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 993 L S W TS KICKEN SR ED ALFC K SLMN LL F SLHV SYKSPVI LL RDLS Q DIHGH LGDID Q D V E V E kt N H FAIVNLR T A A PT V CL 1072
Cdd:cd11720 920 L T W LL KICKEN EL ED SSVA K AVLT LL L SLHV RTQEYLE LL DEVA Q ELCAV LGDID E D E E T E -- S H KLKIINE T T A ES V LT 997
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 1073 L V L SQAE KVL EE VDWLI TK LK GQVSQET L SE E A S S Q ATLPNQPV E KA I IM QL GTLL T FFH ELV Q TA L P S GSC V D T LLK D L 1152
Cdd:cd11720 998 L L L ASLD KVL DD VDWLI KR LK AELNVDQ L PG E D S E Q SQGNLKSI E RS I CE QL YHIA T VLT ELV N TA I P P GSC A D A LLK L L 1077
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 1153 C K M Y T TL TA L VRYYLQVCQSSGGI P KN - M EKLV K L S G SH LTP LC Y S FI S YV QN ks KSLNYTGE KK E K P A AVATAMARV LR 1231
Cdd:cd11720 1078 I K L Y K TL SN L TKHFIARSTKNPVF P SA k F EKLV E L A G KQ LTP NI Y N FI T YV EE -- NQSEQDSK KK K K K A KSKVQRNKI LR 1155
1210 1220 1230 1240
....*....|....*....|....*....|....*....|....*
gi 2462545024 1232 ETK P IP N LI F AIEQ Y EKFLI H LSKK S KVNLM QH MKLST S RDF K IK 1276
Cdd:cd11720 1156 ETK L IP K LI Y AIEQ F EKFLI Q LSKK T KVNLM RY MKLST T RDF R IK 1200
FANCI_S4
pfam14678 FANCI solenoid 4; This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein.
1031-1282
1.92e-104
FANCI solenoid 4; This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein.
Pssm-ID: 464257
Cd Length: 250
Bit Score: 331.16
E-value: 1.92e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 1031 LL R DL S QD I H GH LGDIDQD v EVE KTN HFAI V N LR TAA p T V CL L V LSQ A E K VL EE VDWLI TK LK GQV S QET L S EE A S SQAT 1110
Cdd:pfam14678 1 LL E DL A QD L H AV LGDIDQD - EVE SSK HFAI I N EK TAA - S V LS L L LSQ L E S VL DD VDWLI SR LK ALL S SNK L A EE E S QSSN 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 1111 LPN - QPV EK AIIM QLGTL L T FFH ELVQTALP S G SCVDT LLK D L C K M YTTLT A L VR YY LQ V CQ S - S G G I PKNM EKLVKLSG 1188
Cdd:pfam14678 79 RDQ l KSR EK SLCS QLGTL V T VLS ELVQTALP P G PAMEA LLK L L T K L YTTLT T L TK YY IA V ST S k Q G L I SAKF EKLVKLSG 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 1189 S HLTP LC Y S FI S YVQ NKSK sl NYTGE KK E K P A AVAT A M A R VLRETK P IPNLIFAIEQYEK F LI H LSKK S KVNLMQ H MKLS 1268
Cdd:pfam14678 159 K HLTP QV Y D FI T YVQ ENQS -- EELSK KK K K K A KSKA A R A K VLRETK L IPNLIFAIEQYEK Y LI Q LSKK T KVNLMQ Y MKLS 236
250
....*....|....
gi 2462545024 1269 TSRDF K I KGNI L DM 1282
Cdd:pfam14678 237 TSRDF R I NATT L QA 250
FANCI_S1-cap
pfam14674 FANCI solenoid 1 cap; This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I ...
1-53
3.14e-22
FANCI solenoid 1 cap; This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I protein.
Pssm-ID: 434117
Cd Length: 53
Bit Score: 90.81
E-value: 3.14e-22
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2462545024 1 MDQKILSLAAE KTADK LQ E FLQTL R E GD LT N L LQ N Q A V KGK VA GALLRAIFKG 53
Cdd:pfam14674 1 MDQKILSLAAE DSTEE LQ K FLQTL T E DE LT E L IT N S A L KGK DV GALLRAIFKG 53
Name
Accession
Description
Interval
E-value
FANCI
cd11720 Fanconi anemia I protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
43-1276
0e+00
Fanconi anemia I protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCI may function as a molecular switch to turn on the FA pathway.
Pssm-ID: 212594 [Multi-domain]
Cd Length: 1202
Bit Score: 1294.58
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 43 AGA LLRAI FK G SP CS EE a GTLR R R K IYTCC I Q L VE S GD L QKEI A SE II GL L M LE AHHF PG PL LVEL ANEFISAV R E G SLV 122
Cdd:cd11720 3 TIK LLRAI LL G LS CS PD - SASK R L K VVKSV I N L LN S AE L STKV A FD II SR L L LE LPKL PG EQ LVEL VELCVDGI R N G DNS 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 123 NG KSLE LLP I IL T AL ATK KE n LA Y GK G V L S G E E C K K Q L IN TL CS GR W DQQYVIQ LTSMF K D VP L TA EE VE FVVEK ALSMF 202
Cdd:cd11720 82 NG SWKD LLP T IL S AL SEE KE - IL Y EG G E L T G A E Y K S Q I IN SI CS SK W QPNILTS LTSMF R D LS L SK EE LN FVVEK LCRAL 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 203 SKMN LQE I PPLVYQLLVL S SKG SRKS VLEG IIAF F SA L DKQHNEEQSGD --- E LLDVV T VPSG E L R HV EGT II LHI V FA I 279
Cdd:cd11720 161 KELD LQE L PPLVYQLLVL C SKG DKLL VLEG LQKY F DK L YYKRLLSDANS sst E DDEIE T SSPK E V R EA EGT VL LHI N FA A 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 280 K L D Y ELG R E LV K H LK VG Q QGD s NNN L S PFS IAL LLS VT RI Q RF QD QV L D L LKT SV V K SFK DLQ L L Q G S KF L QN L V - P HRS 358
Cdd:cd11720 241 K Q D H ELG K E FL K L LK SV Q RVP - EKA L T PFS LSV LLS MS RI N RF EE QV F D F LKT AI V R SFK EKE L Q Q N S AW L RE L L l P QVK 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 359 Y V STMI L E VVKNSV HSW DHVT Q GLV E LGFIL MD SYGPK KV L D gktietsp S L S RM P NQH A CK LG AN ILL ET FK I HE MI R Q 438
Cdd:cd11720 320 D V EKIL L R VVKNSV SGR DHVT P GLV N LGFIL LE SYGPK AS L E -------- S G S KT P APK A WQ LG IK ILL KI FK K HE IA R S 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 439 EILEQ VL NR V VT RA S s P I S HFL D L LS NI V MY APL VLQSCS SK V TE AF DYL S F L P LQTVQ RLLKA V QPLLK V S M S M RD C LI 518
Cdd:cd11720 392 EILEQ LK NR I VT LP S - P V S QYI D C LS YL V QS APL LMLEHV SK I TE LL DYL T F I P GSSAM RLLKA I QPLLK I S R S L RD S LI 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 519 LVLRKA M F ANQLDA R KS AV A GFLLLLKN F K V L G SL S SSQ C S QSL S VS Q VHV DVHS H Y - N S VA NE TF CLEI MDS LRRCL S Q 597
Cdd:cd11720 471 LVLRKA L F SRETET R QM AV T GFLLLLKN L K L L S SL G SSQ S S SAS S ST Q ASI DVHS Q Y s S S ES NE SL CLEI LGL LRRCL T Q 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 598 QA D VRLMLYEG F Y D V LR RN SQ LA NS V MQT LL SQL K Q F Y E PKP D L L P PLKLE A C IL TQGD K I S LQEPL DY L LC CIQHCL AW 677
Cdd:cd11720 551 QA E VRLMLYEG L Y R V VL RN PE LA PH V LDL LL PHF K S F F E EDE D V L L PLKLE S C VT TQGD D I V LQEPL GH L IF CIQHCL LL 630
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 678 Y K ntviplq Q GEEEEEEEE A FYEDLDDI LESI TN RMIK S ELEDFELDKSADFS QST S I G I K NNIC A F L VM G VC EVLIEY N 757
Cdd:cd11720 631 S K ------- Q NNSGRPDAA A ALLEESLM LESI CK RMIK V ELEDFELDKSADFS VNS S V G Q K KLLN A L L LL G IY EVLIEY I 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 758 F S I SSF - SKN RFED IL S LF MC Y KK L S D IL nekagkaktkman KTSDS LL --- S MKFVSSLL T A L F RS SN EFMRY AVN V A L 833
Cdd:cd11720 704 F N I WNK v SKN ACKE IL G LF KL Y ES L L D LV ------------- SKLLT LL fdt S VQYATEDQ T S L L RS NR EFMRY ILS V C L 770
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 834 QK V Q Q LK E T GHVS G pd GQ NPEK IFQNLCDIT R VL LW R YT S IP T SV eesg KK EK GK S I S LL C LE GLQK I FSA V Q Q F Y QP K I 913
Cdd:cd11720 771 QK L Q S LK N T PDYD G -- GQ HSKR IFQNLCDIT K VL YL R KI S KL T EL ---- KK DF GK Q I A LL A LE CFLE I LNV V L Q L Y PS K L 844
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 914 QQ FL RAL DV T D kegee REDADVSVTQRTA FQIR Q F Q RSL LN LLS SQ E - EDF N SKE ALL L VTV L TS LS KL L E P S S P Q FV QM 992
Cdd:cd11720 845 ED FL SVI DV E D ----- GGGEKSTIDEQLH FQIR H F I RSL MK LLS TE E e EDF V SKE VVI L IEI L SV LS DK L P P N S T Q AK QM 919
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 993 L S W TS KICKEN SR ED ALFC K SLMN LL F SLHV SYKSPVI LL RDLS Q DIHGH LGDID Q D V E V E kt N H FAIVNLR T A A PT V CL 1072
Cdd:cd11720 920 L T W LL KICKEN EL ED SSVA K AVLT LL L SLHV RTQEYLE LL DEVA Q ELCAV LGDID E D E E T E -- S H KLKIINE T T A ES V LT 997
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 1073 L V L SQAE KVL EE VDWLI TK LK GQVSQET L SE E A S S Q ATLPNQPV E KA I IM QL GTLL T FFH ELV Q TA L P S GSC V D T LLK D L 1152
Cdd:cd11720 998 L L L ASLD KVL DD VDWLI KR LK AELNVDQ L PG E D S E Q SQGNLKSI E RS I CE QL YHIA T VLT ELV N TA I P P GSC A D A LLK L L 1077
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 1153 C K M Y T TL TA L VRYYLQVCQSSGGI P KN - M EKLV K L S G SH LTP LC Y S FI S YV QN ks KSLNYTGE KK E K P A AVATAMARV LR 1231
Cdd:cd11720 1078 I K L Y K TL SN L TKHFIARSTKNPVF P SA k F EKLV E L A G KQ LTP NI Y N FI T YV EE -- NQSEQDSK KK K K K A KSKVQRNKI LR 1155
1210 1220 1230 1240
....*....|....*....|....*....|....*....|....*
gi 2462545024 1232 ETK P IP N LI F AIEQ Y EKFLI H LSKK S KVNLM QH MKLST S RDF K IK 1276
Cdd:cd11720 1156 ETK L IP K LI Y AIEQ F EKFLI Q LSKK T KVNLM RY MKLST T RDF R IK 1200
FANCI_S4
pfam14678 FANCI solenoid 4; This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein.
1031-1282
1.92e-104
FANCI solenoid 4; This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein.
Pssm-ID: 464257
Cd Length: 250
Bit Score: 331.16
E-value: 1.92e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 1031 LL R DL S QD I H GH LGDIDQD v EVE KTN HFAI V N LR TAA p T V CL L V LSQ A E K VL EE VDWLI TK LK GQV S QET L S EE A S SQAT 1110
Cdd:pfam14678 1 LL E DL A QD L H AV LGDIDQD - EVE SSK HFAI I N EK TAA - S V LS L L LSQ L E S VL DD VDWLI SR LK ALL S SNK L A EE E S QSSN 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 1111 LPN - QPV EK AIIM QLGTL L T FFH ELVQTALP S G SCVDT LLK D L C K M YTTLT A L VR YY LQ V CQ S - S G G I PKNM EKLVKLSG 1188
Cdd:pfam14678 79 RDQ l KSR EK SLCS QLGTL V T VLS ELVQTALP P G PAMEA LLK L L T K L YTTLT T L TK YY IA V ST S k Q G L I SAKF EKLVKLSG 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 1189 S HLTP LC Y S FI S YVQ NKSK sl NYTGE KK E K P A AVAT A M A R VLRETK P IPNLIFAIEQYEK F LI H LSKK S KVNLMQ H MKLS 1268
Cdd:pfam14678 159 K HLTP QV Y D FI T YVQ ENQS -- EELSK KK K K K A KSKA A R A K VLRETK L IPNLIFAIEQYEK Y LI Q LSKK T KVNLMQ Y MKLS 236
250
....*....|....
gi 2462545024 1269 TSRDF K I KGNI L DM 1282
Cdd:pfam14678 237 TSRDF R I NATT L QA 250
FANCI_HD2
pfam14680 FANCI helical domain 2; This is the helical domain 2 (HD2) of the Fanconi anemia group I ...
567-785
1.33e-93
FANCI helical domain 2; This is the helical domain 2 (HD2) of the Fanconi anemia group I protein.
Pssm-ID: 464259
Cd Length: 233
Bit Score: 300.76
E-value: 1.33e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 567 V H VDVHS H YN SV ANE TF CLEI MDS LRRCLSQQADV RL MLYEG F YDV LR RN S QLA N SV MQT LL SQL K QF YE PKP D L LPPLK 646
Cdd:pfam14680 13 V Q VDVHS R YN KA ANE AL CLEI LGI LRRCLSQQADV KI MLYEG L YDV VT RN P QLA E SV LDM LL PHF K RY YE EDE D V LPPLK 92
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 647 L EA CI LT QGD KIS LQEPL DY LL C CI QHC L AWYKNTVIPLQQ ge EEE E E EE AFYED L D DILES ITN RMIK SE LEDFELDKS 726
Cdd:pfam14680 93 L DK CI TA QGD QVV LQEPL AH LL S CI SCI L LKLQSFDSFSPS -- QDN E G EE SLVDE L A DILES LCR RMIK CD LEDFELDKS 170
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462545024 727 AD F S QS TS I G I KN NIC A F LV M G VC EVLIEYNFSI SSF SK NR --- F E D ILSLF MC Y K KLS D IL 785
Cdd:pfam14680 171 AD L S SA TS V G V KN LLY A Q LV L G IY EVLIEYNFSI GNW SK EK eed A E E ILSLF KG Y S KLS E IL 232
FANCI_S1
pfam14675 FANCI solenoid 1; This is the solenoid 1 (S1) domain of the Fanconi anemia group I protein.
64-280
5.19e-93
FANCI solenoid 1; This is the solenoid 1 (S1) domain of the Fanconi anemia group I protein.
Pssm-ID: 464254
Cd Length: 221
Bit Score: 298.39
E-value: 5.19e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 64 R R R K I Y TCCI QL V ESG D L QKEI AS E IIG L LMLE A H H F P G PL LVEL ANEFIS A V REG SLVN GK S L E LLP II L TA L A t KK E N 143
Cdd:pfam14675 3 K R L K V Y KSVL QL L ESG E L SEKQ AS D IIG R LMLE L H K F S G DH LVEL VELCLD A I REG DAKC GK W L D LLP KV L SV L S - EE E R 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 144 L A YG K G V LSGEE C K K Q L IN T LCS G RW DQ Q Y VI Q L T SMF K D V PL TA EE V EFVV E K A L S M FS K MN LQE I PPLVYQLL V L S SK 223
Cdd:pfam14675 82 L N YG G G E LSGEE Y K S Q I IN S LCS S RW PP Q I VI S L A SMF R D L PL SK EE L EFVV N K L L R M LK K LD LQE L PPLVYQLL L L C SK 161
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462545024 224 GS R K SV LEG I I AF F SALDKQ ---- HN E EQ S G D ELL d VV TV PSG ELR H VEGT II LHI V FA I K 280
Cdd:pfam14675 162 GS K K VI LEG L I KY F AENYYK rqds NS E SN S N D FDS - IE TV SDK ELR E VEGT VL LHI N FA A K 221
FANCI_S3
pfam14677 FANCI solenoid 3; This is the solenoid 3 (S3) domain of the Fanconi anemia group I protein.
804-1018
6.91e-68
FANCI solenoid 3; This is the solenoid 3 (S3) domain of the Fanconi anemia group I protein.
Pssm-ID: 464256
Cd Length: 216
Bit Score: 227.55
E-value: 6.91e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 804 L L SMK FVS S LLT A LF --------------- RS SN EF M RYA VN VALQKVQQL K ET gh VS GP D GQN PE K I F Q NLCDITRVL L 868
Cdd:pfam14677 1 I L DLG FVS R LLT L LF rdsvqwaheeslsvl RS NK EF V RYA LS VALQKVQQL R ET -- TD GP E GQN SK K T F K NLCDITRVL Y 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 869 WR Y ts IP TS VEESGK KE K gk S ISLL C LE GLQK I FSAV QQ F Y QP K IQQ FL R A L D V TD kegeeredad VSV T QRTA F Q IRQF 948
Cdd:pfam14677 79 WR C -- IP SA VEESGK FD K -- Q ISLL A LE CFLE I LNTA QQ L Y PS K FSE FL K A I D E TD ---------- EDL T EQLK F L IRQF 144
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462545024 949 QR S L L N L LS SQ EEDF N -- SK E ALLLV TV L TS LSK L LEP S S P QFVQML S W TS KICKEN SR EDA LF CK S L MN LL 1018
Cdd:pfam14677 145 QR V L V N Q LS ED EEDF S ia SK L ALLLV NI L SL LSK H LEP N S R QFVQML T W LV KICKEN NL EDA AV CK G L LS LL 216
FANCI_S2
pfam14676 FANCI solenoid 2; This is the solenoid 2 (S2) domain of the Fanconi anemia group I protein.
378-541
1.39e-67
FANCI solenoid 2; This is the solenoid 2 (S2) domain of the Fanconi anemia group I protein.
Pssm-ID: 464255 [Multi-domain]
Cd Length: 154
Bit Score: 224.37
E-value: 1.39e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 378 V T QGLV E LGF I L M DSYG PK kvldgktiet S P S L S RM P N Q H A CK LG AN ILLE T FK I H E MIR Q EILEQ VL NR V V TRA SSP IS 457
Cdd:pfam14676 1 V V QGLV Q LGF V L L DSYG KA ---------- S G S K S KT P A Q R A WQ LG IK ILLE L FK K H D MIR S EILEQ LV NR I V SKS SSP QQ 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 458 H FL DLLS NI V MY APL V L QSC SSK VT E AF DYLSFLPL Q T V QRLL K AVQPL L KVSMS M RD C LILVLRKA M F ANQ LDARK S AV 537
Cdd:pfam14676 71 H YI DLLS KL V KS APL L L LEH SSK LK E LL DYLSFLPL S T A QRLL T AVQPL I KVSMS L RD S LILVLRKA L F SRE LDARK M AV 150
....
gi 2462545024 538 A GFL 541
Cdd:pfam14676 151 S GFL 154
FANCI_HD1
pfam14679 FANCI helical domain 1; This is the helical domain 1 (HD1) of the Fanconi anemia group I ...
284-370
3.29e-31
FANCI helical domain 1; This is the helical domain 1 (HD1) of the Fanconi anemia group I protein.
Pssm-ID: 464258
Cd Length: 86
Bit Score: 117.72
E-value: 3.29e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545024 284 ELGREL V K H LK VG Q q GDSNNN LSPF SI ALLLSV T RI Q RF QD QV L DLLKT SV VKSFKD L Q L LQGSK F L QN L V P HRSY VS TM 363
Cdd:pfam14679 1 ELGREL L K Y LK SD Q - NVPERI LSPF TV ALLLSV A RI P RF EE QV F DLLKT AI VKSFKD E Q K LQGSK W L RD L L P DSCD VS QI 79
....*..
gi 2462545024 364 IL E VVKN 370
Cdd:pfam14679 80 IL K VVKN 86
FANCI_S1-cap
pfam14674 FANCI solenoid 1 cap; This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I ...
1-53
3.14e-22
FANCI solenoid 1 cap; This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I protein.
Pssm-ID: 434117
Cd Length: 53
Bit Score: 90.81
E-value: 3.14e-22
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2462545024 1 MDQKILSLAAE KTADK LQ E FLQTL R E GD LT N L LQ N Q A V KGK VA GALLRAIFKG 53
Cdd:pfam14674 1 MDQKILSLAAE DSTEE LQ K FLQTL T E DE LT E L IT N S A L KGK DV GALLRAIFKG 53
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
