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Conserved domains on  [gi|2462527424|ref|XP_054225848|]
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zinc finger protein 143 isoform X4 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-407 8.29e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.04  E-value: 8.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 234 AHHLKVHERSHTGdRPYQCEHAGCGKAFATGYGLKSHVRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 309
Cdd:COG5048   273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 310 FKCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 384
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180
                  ....*....|....*....|...
gi 2462527424 385 SSLYKHHVVHTHSKPYNCNHCGK 407
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-407 8.29e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.04  E-value: 8.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 234 AHHLKVHERSHTGdRPYQCEHAGCGKAFATGYGLKSHVRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 309
Cdd:COG5048   273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 310 FKCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 384
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180
                  ....*....|....*....|...
gi 2462527424 385 SSLYKHHVVHTHSKPYNCNHCGK 407
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-323 1.35e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.35e-05
                          10        20
                  ....*....|....*....|....*...
gi 2462527424 296 DLQKHIRTHTGERPFKCPFegCGRSFTT 323
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-407 8.29e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.04  E-value: 8.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 234 AHHLKVHERSHTGdRPYQCEHAGCGKAFATGYGLKSHVRT--HTGE--KPYRCSEDNCTKSFKTSGDLQKHIRTHTGERP 309
Cdd:COG5048   273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 310 FKCPFEGCGRSFTTSNIRKVHVRTH-----TGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEY 384
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                         170       180
                  ....*....|....*....|...
gi 2462527424 385 SSLYKHHVVHTHSKPYNCNHCGK 407
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
338-413 3.98e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 3.98e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462527424 338 RPYYCtePGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQIS 413
Cdd:COG5048    32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 366-423 4.32e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 55.88  E-value: 4.32e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462527424 366 GEKPYVCTVPGCDKRFTEYSSLyKHHVVHTH--------------------SKPYNCNHCGKTYKQISTLAMHKRTAH 423
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHqnqklhenpspekmnifsakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 232-396 1.12e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 54.34  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 232 TTAHHLKVHERSHTGDRPYQCEHAGCGK---AFATGYGLKSHVRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIrthtGER 308
Cdd:COG5189   273 SQGSAELFEESSLGFDYEFIHKSVGNKEirgGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDTPSRMLKVK----DGK 348

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 309 PFKCPFEGCGRSFTTSNIRKVHvRTHTGERPYYCTEPgcgrafasatNYKNHVRIHTGEKPYVCTVpgCDKRFTEYSSLy 388
Cdd:COG5189   349 PYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHENP----------SPEKMNIFSAKDKPYRCEV--CDKRYKNLNGL- 414


                  ....*...
gi 2462527424 389 KHHVVHTH 396
Cdd:COG5189   415 KYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-305 2.10e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.10e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462527424 247 DRPYQCEhaGCGKAFATGYGLKSHVRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHT 305
Cdd:COG5048    31 PRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
342-425 6.54e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 6.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 342 CTEPGCGRAFASATNYKNHVR--IHTGE--KPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNC--NHCGKTYKQIST- 414
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNn 369

                          90
                  ....*....|....*
gi 2462527424 415 ----LAMHKRTAHND 425
Cdd:COG5048   370 eppqSLQQYKDLKND 384
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
215-391 1.16e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 215 SGEKAFRCEYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKafatgyglkshvrTHTGEKPYrcsednctksfKTS 294
Cdd:COG5048   317 ESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS-------------KFSPLLNN-----------EPP 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 295 GDLQKHIRTHTgERPFKCPFEGCGRSFTTSNIRKVHVRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCtv 374
Cdd:COG5048   373 QSLQQYKDLKN-DKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-- 449

                         170
                  ....*....|....*..
gi 2462527424 375 pgCDKRFTEYSSLYKHH 391
Cdd:COG5048   450 --SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-323 1.35e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.35e-05
                          10        20
                  ....*....|....*....|....*...
gi 2462527424 296 DLQKHIRTHTGERPFKCPFegCGRSFTT 323
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-428 1.87e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 278 KPYRCseDNCTKSFKTSGDLQKHIRTHTGERPFKCPFEGCGRSFTTSNIRKVHVRTHTgERPYYCTEPGCGRAFASATNY 357
Cdd:COG5048    32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH-NNPSDLNSKSLPLSNSKASSS 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462527424 358 KNHvrIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHS---KPYNCNHCGKTYKQISTLAMHKRTAHNDTEP 428
Cdd:COG5048   109 SLS--SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLrnnPLPGNNSSSVNTPQSNSLHPPLPANSLSKDP 180
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-293 2.08e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.08e-05
                          10        20
                  ....*....|....*....|....*..
gi 2462527424 267 LKSHVRTHTGEKPYRCSEdnCTKSFKT 293
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 252-339 5.17e-05

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 42.41  E-value: 5.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 252 CEHAGCGKAFATGYGLKSHVRTHTGE------KPYRCSEDNCTKSFKTSGDLQKHIRTH-TGERPFKCpfEGCGRSFTT- 323
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKC--ENCLLRFRTh 79

                          90
                  ....*....|....*..
gi 2462527424 324 -SNIRKVHVRTHTGERP 339
Cdd:pfam15909  80 rSLFKHLHVCAEHAQSP 96
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 216-275 8.92e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 8.92e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462527424 216 GEKAFRCEYDGCGKLYTTAHHLKVH---------------ERSHTG----DRPYQCEHagCGKAFATGYGLKSHvRTHT 275
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
236-263 1.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.45e-04
                          10        20
                  ....*....|....*....|....*...
gi 2462527424 236 HLKVHERSHTGDRPYQCEHagCGKAFAT 263
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-382 2.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.07e-04
                          10        20
                  ....*....|....*....|....*..
gi 2462527424 356 NYKNHVRIHTGEKPYVCTVpgCDKRFT 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
204-441 1.38e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 204 HATRVTAKS-QQSGEKAFRCEY-DGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKAFATGYGLKSHVRTHTGEKPYR 281
Cdd:COG5048    14 SVLSSTPKStLKSLSNAPRPDScPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 282 CSEDNCTKSFKTSGDL----------------------QKHIRTHTGERP---FKCPFEGCGRSFT----TSNIRKVHVR 332
Cdd:COG5048    94 NSKSLPLSNSKASSSSlsssssnsndnnllsshslppsSRDPQLPDLLSIsnlRNNPLPGNNSSSVntpqSNSLHPPLPA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 333 THTGERPYYCTEPGCGRAFASA--TNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHS---------KPYN 401
Cdd:COG5048   174 NSLSKDPSSNLSLLISSNVSTSipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqspsslsSSDS 253

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2462527424 402 CNHCGKTYKQISTLAMHKRTAHNDTEpiEEEQEAFFEPPP 441
Cdd:COG5048   254 SSSASESPRSSLPTASSQSSSPNESD--SSSEKGFSLPIK 291
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 282-398 1.74e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.17  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527424 282 CSEDNCTKSFKTSGDLQKHIRTHTgerPFKCPFEGcgrsfttsnirkvhvrthtgeRPYYCTEPGCGRAFASATNYKNHV 361
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHC---PPTQSLEG---------------------KLFRCSALSCTETFPSMQELVAHS 57

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462527424 362 RIHTGEKPYVcTVPGCDKRFTEYSSLYKH-HVVHTHSK 398
Cdd:pfam15909  58 KLHYKPNRYF-KCENCLLRFRTHRSLFKHlHVCAEHAQ 94
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 280-304 1.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.78e-03
                          10        20
                  ....*....|....*....|....*
gi 2462527424 280 YRCSEdnCTKSFKTSGDLQKHIRTH 304
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 2.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.43e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462527424 328 KVHVRTHTGERPYYCTEpgCGRAFAS 353
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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