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Conserved domains on  [gi|2462521167|ref|XP_054222799|]
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leucine-rich repeat-containing protein 27 isoform X8 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-155 1.45e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
Cdd:COG4886   140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                          90       100
                  ....*....|....*....|....*...
gi 2462521167 128 MLPVELGSVTTLKALNLRHCPLEFPPQL 155
Cdd:COG4886   219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-155 1.45e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
Cdd:COG4886   140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                          90       100
                  ....*....|....*....|....*...
gi 2462521167 128 MLPVELGSVTTLKALNLRHCPLEFPPQL 155
Cdd:COG4886   219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR_8 pfam13855
Leucine rich repeat;
67-126 6.47e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 6.47e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462521167  67 PSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAH-QHLKTLLLERNPI 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-146 5.62e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  50 LDLSESGLC-RLE-EVFRIPSLQQLHLQRNAlcvipqdFFQLLP------NLTWLDLRYNRIK-ALPSGIGAHQHLKTLL 120
Cdd:PLN00113  433 LDISNNNLQgRINsRKWDMPSLQMLSLARNK-------FFGGLPdsfgskRLENLDLSRNQFSgAVPRKLGSLSELMQLK 505

                          90       100
                  ....*....|....*....|....*..
gi 2462521167 121 LERNPIK-MLPVELGSVTTLKALNLRH 146
Cdd:PLN00113  506 LSENKLSgEIPDELSSCKKLVSLDLSH 532
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-129 3.89e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 3.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  50 LDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQdfFQLLPNLTWLDLRYNRIKALPsGIGAHQHLKTLLLERNPIKML 129
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV 83
LRR smart00370
Leucine-rich repeats, outliers;
90-113 1.64e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 1.64e-03
                           10        20
                   ....*....|....*....|....
gi 2462521167   90 LPNLTWLDLRYNRIKALPSGIGAH 113
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-155 1.45e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
Cdd:COG4886   140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                          90       100
                  ....*....|....*....|....*...
gi 2462521167 128 MLPVELGSVTTLKALNLRHCPLEFPPQL 155
Cdd:COG4886   219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-155 3.30e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 3.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  52 LSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPV 131
Cdd:COG4886    98 LTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANL-TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE 176

                          90       100
                  ....*....|....*....|....*
gi 2462521167 132 ELGSVTTLKALNLRHCPL-EFPPQL 155
Cdd:COG4886   177 ELGNLTNLKELDLSNNQItDLPEPL 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-150 2.68e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 2.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  50 LDLSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSgIGAHQHLKTLLLERNPIKM 128
Cdd:COG4886   187 LDLSNNQITDLPEPLgNLTNLEELDLSGNQLTDLPEPLANL-TNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTD 264

                          90       100
                  ....*....|....*....|..
gi 2462521167 129 LPvELGSVTTLKALNLRHCPLE 150
Cdd:COG4886   265 LP-PLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-150 2.76e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 2.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  50 LDLSESGLCRLEEVFRIPSLQQLHLQRNalcvipqDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKML 129
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                          90       100
                  ....*....|....*....|.
gi 2462521167 130 PVELGSVTTLKALNLRHCPLE 150
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLT 172
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-132 8.44e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 8.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQdfFQLLPNLTWLDLRYNRIKALPSgIGAHQHLKTLLLERNPIKM 128
Cdd:COG4886   210 LDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286


                  ....
gi 2462521167 129 LPVE 132
Cdd:COG4886   287 LKLK 290
LRR_8 pfam13855
Leucine rich repeat;
67-126 6.47e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 6.47e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462521167  67 PSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAH-QHLKTLLLERNPI 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-106 5.40e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 5.40e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462521167  49 ILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFqlLPNLTWLDLRYNRIKAL 106
Cdd:COG4886   232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQLTDL 287
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-146 5.62e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  50 LDLSESGLC-RLE-EVFRIPSLQQLHLQRNAlcvipqdFFQLLP------NLTWLDLRYNRIK-ALPSGIGAHQHLKTLL 120
Cdd:PLN00113  433 LDISNNNLQgRINsRKWDMPSLQMLSLARNK-------FFGGLPdsfgskRLENLDLSRNQFSgAVPRKLGSLSELMQLK 505

                          90       100
                  ....*....|....*....|....*..
gi 2462521167 121 LERNPIK-MLPVELGSVTTLKALNLRH 146
Cdd:PLN00113  506 LSENKLSgEIPDELSSCKKLVSLDLSH 532
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-129 3.89e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 3.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  50 LDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQdfFQLLPNLTWLDLRYNRIKALPsGIGAHQHLKTLLLERNPIKML 129
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-123 4.46e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 4.46e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462521167  57 LCRLEEVFRIPSLQQLHLQRNALCVIpqDFFQLLPNLTWLDLRYNRIKALpSGIGAHQHLKTLLLER 123
Cdd:cd21340    36 ITKIENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEN 99
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 63-144 1.56e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  63 VFRIPSLQQLHLQRNALC-VIPQDFFQLLPNLTWLDLRYNRIK-ALPSgiGAHQHLKTLLLERNPIK-MLPVELGSVTTL 139
Cdd:PLN00113   89 IFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIGSFSSL 166


                  ....*
gi 2462521167 140 KALNL 144
Cdd:PLN00113  167 KVLDL 171
LRR smart00370
Leucine-rich repeats, outliers;
90-113 1.64e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 1.64e-03
                           10        20
                   ....*....|....*....|....
gi 2462521167   90 LPNLTWLDLRYNRIKALPSGIGAH 113
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
90-113 1.64e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 1.64e-03
                           10        20
                   ....*....|....*....|....
gi 2462521167   90 LPNLTWLDLRYNRIKALPSGIGAH 113
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 50-150 2.18e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521167  50 LDLSESGLC-----RLEEVFRIPSLQQLHLQRNALCVIPQDFFQ-----LLPNLTWLDLRYNRI-----KALPSGIGAHQ 114
Cdd:cd00116    86 LDLSDNALGpdgcgVLESLLRSSSLQELKLNNNGLGDRGLRLLAkglkdLPPALEKLVLGRNRLegascEALAKALRANR 165

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462521167 115 HLKTLLLERNP-----IKMLPVELGSVTTLKALNLRHCPLE 150
Cdd:cd00116   166 DLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNGLT 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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