NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462616902|ref|XP_054215360|]
View 

general transcription factor II-I repeat domain-containing protein 1 isoform X5 [Homo sapiens]

Protein Classification

GTF2I repeat domain-containing protein( domain architecture ID 10502974)

GTF2I repeat domain-containing protein may be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 160-234 1.30e-35

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 129.27  E-value: 1.30e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462616902 160 LRKMVEEVFDVLYSEALGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKR 234
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 597-671 8.25e-35

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 126.96  E-value: 8.25e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462616902 597 LRKQVELLFNTRYAKAIGISEPVKVPYSKFLMHPEELFVVGLPEGISLRRPNCFGIAKLRKILEASNSIQFVIKR 671
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 800-872 2.31e-32

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 120.03  E-value: 2.31e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462616902 800 LREQVKELFNEKYGEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVI 872
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVI 73
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 703-777 9.85e-29

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 109.63  E-value: 9.85e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462616902 703 LREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKPCTFGSQNLERILAVADKIKFTVTR 777
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 383-457 3.99e-28

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 108.09  E-value: 3.99e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462616902 383 LRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKR 457
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
 
Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 160-234 1.30e-35

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 129.27  E-value: 1.30e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462616902 160 LRKMVEEVFDVLYSEALGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKR 234
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 597-671 8.25e-35

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 126.96  E-value: 8.25e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462616902 597 LRKQVELLFNTRYAKAIGISEPVKVPYSKFLMHPEELFVVGLPEGISLRRPNCFGIAKLRKILEASNSIQFVIKR 671
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 800-872 2.31e-32

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 120.03  E-value: 2.31e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462616902 800 LREQVKELFNEKYGEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVI 872
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVI 73
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 703-777 9.85e-29

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 109.63  E-value: 9.85e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462616902 703 LREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKPCTFGSQNLERILAVADKIKFTVTR 777
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 383-457 3.99e-28

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 108.09  E-value: 3.99e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462616902 383 LRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKR 457
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
 
Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 160-234 1.30e-35

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 129.27  E-value: 1.30e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462616902 160 LRKMVEEVFDVLYSEALGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKR 234
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 597-671 8.25e-35

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 126.96  E-value: 8.25e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462616902 597 LRKQVELLFNTRYAKAIGISEPVKVPYSKFLMHPEELFVVGLPEGISLRRPNCFGIAKLRKILEASNSIQFVIKR 671
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 800-872 2.31e-32

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 120.03  E-value: 2.31e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462616902 800 LREQVKELFNEKYGEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVI 872
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVI 73
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 703-777 9.85e-29

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 109.63  E-value: 9.85e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462616902 703 LREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKPCTFGSQNLERILAVADKIKFTVTR 777
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 383-457 3.99e-28

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 108.09  E-value: 3.99e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462616902 383 LRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKR 457
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH