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Conserved domains on  [gi|2462614406|ref|XP_054214202|]
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importin subunit alpha-8 isoform X5 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
7-488 6.25e-156

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 454.73  E-value: 6.25e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406   7 PEERRRKFKYRGK-DVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKGVAVSLTLGEIIKGVNSSDPV 85
Cdd:COG5064     7 PEARRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  86 LCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELL 165
Cdd:COG5064    87 QQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 166 SSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILP 244
Cdd:COG5064   167 SSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALP 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 245 ALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 324
Cdd:COG5064   247 ILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINC 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 325 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQ 402
Cdd:COG5064   327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLNrpDI 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 403 LIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAE----KRSEKENL-CLLIEELGGIDRIEALQLHENRQIGQS 477
Cdd:COG5064   407 IRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdrlRYGKNINIyAVYVEKAGGMDAIHGLQDSVNRTIYDK 486

                         490
                  ....*....|.
gi 2462614406 478 ALNIIEKHFGE 488
Cdd:COG5064   487 AYSIIEKFFGE 497
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
7-488 6.25e-156

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 454.73  E-value: 6.25e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406   7 PEERRRKFKYRGK-DVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKGVAVSLTLGEIIKGVNSSDPV 85
Cdd:COG5064     7 PEARRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  86 LCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELL 165
Cdd:COG5064    87 QQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 166 SSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILP 244
Cdd:COG5064   167 SSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALP 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 245 ALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 324
Cdd:COG5064   247 ILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINC 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 325 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQ 402
Cdd:COG5064   327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLNrpDI 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 403 LIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAE----KRSEKENL-CLLIEELGGIDRIEALQLHENRQIGQS 477
Cdd:COG5064   407 IRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdrlRYGKNINIyAVYVEKAGGMDAIHGLQDSVNRTIYDK 486

                         490
                  ....*....|.
gi 2462614406 478 ALNIIEKHFGE 488
Cdd:COG5064   487 AYSIIEKFFGE 497
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 10-92 2.00e-25

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 99.53  E-value: 2.00e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  10 RRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNIT-SFCPDTPSEKTakgvaVSLTLGEIIKGVNSSDPVLCF 88
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGaPSSSSSSAESQ-----LLESLPEMVQGVNSDDPELQL 75


                  ....
gi 2462614406  89 QATQ 92
Cdd:pfam01749  76 EATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 314-354 5.04e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.96  E-value: 5.04e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462614406  314 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 354
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 131-393 1.94e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.32  E-value: 1.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  131 QFEAAWALTNIASGTSEQTR-AVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALIsp 209
Cdd:PLN03200   462 QQEYAVALLAILTDEVDESKwAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLL-- 539

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  210 tlpitflrnitwtlsnlcRNKNPYPCDTAVKqilpALLHLLQHQDSEVLSDacwALSYLTDGSNKRIGQVVNtgVLPRlv 289
Cdd:PLN03200   540 ------------------KNGGPKGQEIAAK----TLTKLVRTADAATISQ---LTALLLGDLPESKVHVLD--VLGH-- 590

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  290 VLMTSSELNVLTP------SLRTVGNIVTGTDEQTQ--------------------MAIDAgMLNVLPQLLQHNKPSIQK 343
Cdd:PLN03200   591 VLSVASLEDLVREgsaandALRTLIQLLSSSKEETQekaasvladifssrqdlcesLATDE-IINPCIKLLTNNTEAVAT 669

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462614406  344 EAAWALSNVaAGPCHHIQQL--LAYDVLPPLVALLKNGEFKVQKEAVWMVAN 393
Cdd:PLN03200   670 QSARALAAL-SRSIKENRKVsyAAEDAIKPLIKLAKSSSIEVAEQAVCALAN 720
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
7-488 6.25e-156

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 454.73  E-value: 6.25e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406   7 PEERRRKFKYRGK-DVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKGVAVSLTLGEIIKGVNSSDPV 85
Cdd:COG5064     7 PEARRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  86 LCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELL 165
Cdd:COG5064    87 QQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 166 SSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILP 244
Cdd:COG5064   167 SSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALP 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 245 ALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 324
Cdd:COG5064   247 ILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINC 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 325 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQ 402
Cdd:COG5064   327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLNrpDI 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 403 LIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAE----KRSEKENL-CLLIEELGGIDRIEALQLHENRQIGQS 477
Cdd:COG5064   407 IRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdrlRYGKNINIyAVYVEKAGGMDAIHGLQDSVNRTIYDK 486

                         490
                  ....*....|.
gi 2462614406 478 ALNIIEKHFGE 488
Cdd:COG5064   487 AYSIIEKFFGE 497
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 10-92 2.00e-25

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 99.53  E-value: 2.00e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  10 RRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNIT-SFCPDTPSEKTakgvaVSLTLGEIIKGVNSSDPVLCF 88
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGaPSSSSSSAESQ-----LLESLPEMVQGVNSDDPELQL 75


                  ....
gi 2462614406  89 QATQ 92
Cdd:pfam01749  76 EATQ 79
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 452-491 9.99e-15

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 68.39  E-value: 9.99e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462614406 452 LLIEELGGIDRIEALQLHENRQIGQSALNIIEKHFGEVSD 491
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEE 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 314-354 1.52e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 53.23  E-value: 1.52e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462614406 314 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 354
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 145-184 2.58e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.46  E-value: 2.58e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462614406 145 TSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIA 184
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 314-354 5.04e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.96  E-value: 5.04e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462614406  314 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 354
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 145-184 6.90e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.58  E-value: 6.90e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462614406  145 TSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIA 184
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 130-183 7.97e-07

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 46.21  E-value: 7.97e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462614406 130 LQFEAAWALTNIASGTSEQTRAVVEGgAIQPLIELLSSSNVAVCEQAVWALGNI 183
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 242-270 1.76e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 44.75  E-value: 1.76e-06
                          10        20
                  ....*....|....*....|....*....
gi 2462614406 242 ILPALLHLLQHQDSEVLSDACWALSYLTD 270
Cdd:pfam00514  13 AVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
115-265 2.58e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.93  E-value: 2.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 115 IPRMVEFLKSSlYPCLQFEAAWALTNIASGTseqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIAgdgpefrdnv 194
Cdd:COG1413    18 VPALIAALADE-DPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPEVRAAAAEALGRIG---------- 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462614406 195 iTSNAIPHLL-ALISPTLPITflRNITWTLSNLcrnknpypcdtAVKQILPALLHLLQHQDSEVLSDACWAL 265
Cdd:COG1413    76 -DPEAVPALIaALKDEDPEVR--RAAAEALGRL-----------GDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
134-270 3.09e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.55  E-value: 3.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 134 AAWALTNIasGTSEqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIAGDGpefrdnvitsnAIPHLLALISPTLPI 213
Cdd:COG1413     5 AARALGRL--GDPA---------AVPALIAALADEDPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPE 62

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462614406 214 TfLRNITWTLSNLcrnknpypcdtAVKQILPALLHLLQHQDSEVLSDACWALSYLTD 270
Cdd:COG1413    63 V-RAAAAEALGRI-----------GDPEAVPALIAALKDEDPEVRRAAAEALGRLGD 107
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 231-270 1.36e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 1.36e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462614406  231 NPYPCDTAVKQ-ILPALLHLLQHQDSEVLSDACWALSYLTD 270
Cdd:smart00185   1 DDENKQAVVDAgGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
240-389 6.69e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 6.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 240 KQILPALLHLLQHQDSEVLSDACWALSYLTDgsnkrigqvvnTGVLPRLVVLMTSSELNVLTPSLRTVGNIvtGTDEqtq 319
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALGRI--GDPE--- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 320 mAIDAgmlnvLPQLLQHNKPSIQKEAAWALSNVAAGpchhiqqllayDVLPPLVALLKNGEFKVQKEAVW 389
Cdd:COG1413    79 -AVPA-----LIAALKDEDPEVRRAAAEALGRLGDP-----------AAVPALLEALKDPDWEVRRAAAR 131
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 103-143 1.86e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.97  E-value: 1.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462614406 103 NPPLKLVIEAGLIPRMVEFLKSSlYPCLQFEAAWALTNIAS 143
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 131-393 1.94e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.32  E-value: 1.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  131 QFEAAWALTNIASGTSEQTR-AVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALIsp 209
Cdd:PLN03200   462 QQEYAVALLAILTDEVDESKwAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLL-- 539

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  210 tlpitflrnitwtlsnlcRNKNPYPCDTAVKqilpALLHLLQHQDSEVLSDacwALSYLTDGSNKRIGQVVNtgVLPRlv 289
Cdd:PLN03200   540 ------------------KNGGPKGQEIAAK----TLTKLVRTADAATISQ---LTALLLGDLPESKVHVLD--VLGH-- 590

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  290 VLMTSSELNVLTP------SLRTVGNIVTGTDEQTQ--------------------MAIDAgMLNVLPQLLQHNKPSIQK 343
Cdd:PLN03200   591 VLSVASLEDLVREgsaandALRTLIQLLSSSKEETQekaasvladifssrqdlcesLATDE-IINPCIKLLTNNTEAVAT 669

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462614406  344 EAAWALSNVaAGPCHHIQQL--LAYDVLPPLVALLKNGEFKVQKEAVWMVAN 393
Cdd:PLN03200   670 QSARALAAL-SRSIKENRKVsyAAEDAIKPLIKLAKSSSIEVAEQAVCALAN 720
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 102-143 1.97e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.95  E-value: 1.97e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462614406  102 KNPPLKLVIEAGLIPRMVEFLKSSlYPCLQFEAAWALTNIAS 143
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 358-396 3.24e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.20  E-value: 3.24e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462614406 358 HHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFAT 396
Cdd:pfam00514   3 ENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 339-394 8.38e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 37.35  E-value: 8.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462614406 339 PSIQKEAAWALSNVAaGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANF 394
Cdd:pfam13513   1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 197-388 9.33e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.01  E-value: 9.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  197 SNAIPHLLALI-SPTLPITFlrNITWTLSNLCRNKnpypcDTAVKQIL----PALLHLLQHQDSEVLSDACWALSYLTDG 271
Cdd:PLN03200    57 SQAMPLLVSLLrSGTLGAKV--NAAAVLGVLCKEE-----DLRVKVLLggciPPLLSLLKSGSAEAQKAAAEAIYAVSSG 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  272 SNK-RIGQ--VVNTGVLPRLVVLMTS------SELNVLTPSLRtvgNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQ 342
Cdd:PLN03200   130 GLSdHVGSkiFSTEGVVPSLWDQLQPgnkqdkVVEGLLTGALR---NLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQ 206

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2462614406  343 KEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNG-EFKVQKEAV 388
Cdd:PLN03200   207 ANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQGnEVSVRAEAA 253
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 188-228 1.26e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.66  E-value: 1.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462614406 188 PEFRDNVITSNAIPHLLALISPTlPITFLRNITWTLSNLCR 228
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 217-268 1.69e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.58  E-value: 1.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462614406 217 RNITWTLSNLCrNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYL 268
Cdd:pfam13513   5 EAAALALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 272-312 1.71e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 1.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462614406 272 SNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVT 312
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 94-210 5.95e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.70  E-value: 5.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406   94 ARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSlYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSN-VAV 172
Cdd:PLN03200   170 ALRNLCGSTDGFWSATLEAGGVDILVKLLSSG-NSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQGNeVSV 248

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2462614406  173 CEQAVWALGNIAGDGPEFRDNVITSNAIPHLL-ALISPT 210
Cdd:PLN03200   249 RAEAAGALEALSSQSKEAKQAIADAGGIPALInATVAPS 287
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 115-207 5.98e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.16  E-value: 5.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 115 IPRMVEFLKSSLYPCLQFEAAWALTNIASGTseqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIAgdgpefrdnv 194
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGDPE-----------AVPALLELLKDEDPAVRRAAAEALGKIG---------- 59

                          90
                  ....*....|...
gi 2462614406 195 iTSNAIPHLLALI 207
Cdd:pfam13646  60 -DPEALPALLELL 71
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 358-395 6.84e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 34.33  E-value: 6.84e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462614406  358 HHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFA 395
Cdd:smart00185   3 ENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 310-441 7.11e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.32  E-value: 7.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406  310 IVTGTDEQTQMAID-AGMLNVLPQLLQHNKPSIQKEAAWALSNVaagpCHHIQQLLA----YDVLPPLVALLKNGEFKVQ 384
Cdd:PLN03200   472 ILTDEVDESKWAITaAGGIPPLVQLLETGSQKAKEDSATVLWNL----CCHSEDIRAcvesAGAVPALLWLLKNGGPKGQ 547

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462614406  385 KEAVwmvanfatgATMDQLIQLVHSGVLEPLVNLLT--APDVKIVliILDVISCILQAA 441
Cdd:PLN03200   548 EIAA---------KTLTKLVRTADAATISQLTALLLgdLPESKVH--VLDVLGHVLSVA 595
HEAT COG1413
HEAT repeat [General function prediction only];
115-184 9.05e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 36.53  E-value: 9.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614406 115 IPRMVEFLKSSlYPCLQFEAAWALTNIASGTseqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIA 184
Cdd:COG1413    80 VPALIAALKDE-DPEVRRAAAEALGRLGDPA-----------AVPALLEALKDPDWEVRRAAARALGRLG 137
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 133-187 9.75e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 38.93  E-value: 9.75e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462614406  133 EAAWALTNIASGTSE-QTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDG 187
Cdd:PLN03200   670 QSARALAALSRSIKEnRKVSYAAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDP 725
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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