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Conserved domains on  [gi|2462613565|ref|XP_054213809|]
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autism susceptibility gene 2 protein isoform X20 [Homo sapiens]

Protein Classification

fibrosin/Auts2 domain-containing protein( domain architecture ID 10633998)

fibrosin/Auts2 domain-containing protein similar to human fibrosin-1-like protein, also called autism susceptibility candidate 2 (AUTS2)-like protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Auts2 pfam15336
Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family ...
 469-681 1.37e-82

Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.


:

Pssm-ID: 464656  Cd Length: 217  Bit Score: 267.48  E-value: 1.37e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  469 KPGKWCAMHVHIAWQIYHHQQKVKkQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTP 548
Cdd:pfam15336    1 KPGKWCAMHVRIAWQIYHHQQKVK-QMQLDPHKLDVGLKLELLSRPPGPGVFGGFPYPHDLARPATLFSATGAAHPSATP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  549 FGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHRTPPSFP 628
Cdd:pfam15336   80 FGPSPPHGSFLSPASHLDPFSRPSTFGGLGALSSGAFGGLGSPSLTANSVFGHKEGPPLQGFSSPHDPWNRLHRTPPSFP 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462613565  629 TPPPWLKPGELERSASAAAHDRDRDVDKRD----SSVSKDDKERESVEK-RHSSHPSP 681
Cdd:pfam15336  160 TPPPWPKPGDAERSSSLESHERERDRERERekrdSSVIKDEKDRDSLDKnRHSSRSSP 217
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 142-279 2.52e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 61.59  E-value: 2.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  142 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPlstQPPQGPPEAQLQ-PAPQPQVQRPPRPQSPTQLLHQNLPPV 220
Cdd:pfam09770  219 AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQ---HPGQGHPVTILQrPQSPQPDPAQPSIQPQAQQFHQQPPPV 295

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  221 QAHPSaQSLSQPlsaynsSSLSLNSLSSRSSTPAKTQPAPPHISHH-PSASPFPLSLPNH 279
Cdd:pfam09770  296 PVQPT-QILQNP------NRLSAARVGYPQNPQPGVQPAPAHQAHRqQGSFGRQAPIITH 348
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 113-446 1.91e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  113 ISGLErsQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPqtepqlrAPSPDPDLVQRTEAPPQPPPLSTQP-----PQGP 187
Cdd:PHA03247  2537 IRGLE--ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRP-------APRPSEPAVTSRARRPDAPPQSARPrapvdDRGD 2607

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  188 PEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQpAPPHISHHP 267
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS-SPPQRPRRR 2686

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  268 SASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVA--GHPAGSTYSEQDILRQELNTRFLA 345
Cdd:PHA03247  2687 AARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAppAVPAGPATPGGPARPARPPTTAGP 2766

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  346 SQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMVRTPGrnfdkyPTKVDPfyrh 425
Cdd:PHA03247  2767 PAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP------PTSAQP---- 2836

                          330       340
                   ....*....|....*....|.
gi 2462613565  426 slfhSYPPAVSGIPPMIPPTG 446
Cdd:PHA03247  2837 ----TAPPPPPGPPPPSLPLG 2853
PTZ00121 super family cl31754
MAEBL; Provisional
 663-826 5.46e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 5.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  663 KDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHL-P 741
Cdd:PTZ00121  1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKkA 1440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  742 EKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKgEPAYENPKKSSEVKVKEERKEDHDLPPEAP 821
Cdd:PTZ00121  1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK-KKAEEAKKKADEAKKAAEAKKKADEAKKAE 1519


                   ....*
gi 2462613565  822 QTHRA 826
Cdd:PTZ00121  1520 EAKKA 1524
 
Name Accession Description Interval E-value
Auts2 pfam15336
Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family ...
 469-681 1.37e-82

Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.


Pssm-ID: 464656  Cd Length: 217  Bit Score: 267.48  E-value: 1.37e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  469 KPGKWCAMHVHIAWQIYHHQQKVKkQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTP 548
Cdd:pfam15336    1 KPGKWCAMHVRIAWQIYHHQQKVK-QMQLDPHKLDVGLKLELLSRPPGPGVFGGFPYPHDLARPATLFSATGAAHPSATP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  549 FGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHRTPPSFP 628
Cdd:pfam15336   80 FGPSPPHGSFLSPASHLDPFSRPSTFGGLGALSSGAFGGLGSPSLTANSVFGHKEGPPLQGFSSPHDPWNRLHRTPPSFP 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462613565  629 TPPPWLKPGELERSASAAAHDRDRDVDKRD----SSVSKDDKERESVEK-RHSSHPSP 681
Cdd:pfam15336  160 TPPPWPKPGDAERSSSLESHERERDRERERekrdSSVIKDEKDRDSLDKnRHSSRSSP 217
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 142-279 2.52e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 61.59  E-value: 2.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  142 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPlstQPPQGPPEAQLQ-PAPQPQVQRPPRPQSPTQLLHQNLPPV 220
Cdd:pfam09770  219 AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQ---HPGQGHPVTILQrPQSPQPDPAQPSIQPQAQQFHQQPPPV 295

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  221 QAHPSaQSLSQPlsaynsSSLSLNSLSSRSSTPAKTQPAPPHISHH-PSASPFPLSLPNH 279
Cdd:pfam09770  296 PVQPT-QILQNP------NRLSAARVGYPQNPQPGVQPAPAHQAHRqQGSFGRQAPIITH 348
PHA03247 PHA03247
large tegument protein UL36; Provisional
 140-297 8.02e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 8.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  140 PCPQVAQPIPQPQTEPQLRAPSPdpdlvqrteAPPQPPPLSTQPPQgpPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPP 219
Cdd:PHA03247  2882 PVRRLARPAVSRSTESFALPPDQ---------PERPPQPQAPPPPQ--PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA 2950

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  220 VQAHPSAQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLH--------SFTPTLQP 291
Cdd:PHA03247  2951 GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHeetdpppvSLKQTLWP 3030


                   ....*.
gi 2462613565  292 PAHSHH 297
Cdd:PHA03247  3031 PDDTED 3036
PHA03247 PHA03247
large tegument protein UL36; Provisional
 113-446 1.91e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  113 ISGLErsQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPqtepqlrAPSPDPDLVQRTEAPPQPPPLSTQP-----PQGP 187
Cdd:PHA03247  2537 IRGLE--ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRP-------APRPSEPAVTSRARRPDAPPQSARPrapvdDRGD 2607

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  188 PEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQpAPPHISHHP 267
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS-SPPQRPRRR 2686

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  268 SASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVA--GHPAGSTYSEQDILRQELNTRFLA 345
Cdd:PHA03247  2687 AARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAppAVPAGPATPGGPARPARPPTTAGP 2766

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  346 SQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMVRTPGrnfdkyPTKVDPfyrh 425
Cdd:PHA03247  2767 PAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP------PTSAQP---- 2836

                          330       340
                   ....*....|....*....|.
gi 2462613565  426 slfhSYPPAVSGIPPMIPPTG 446
Cdd:PHA03247  2837 ----TAPPPPPGPPPPSLPLG 2853
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 140-236 1.57e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.57  E-value: 1.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  140 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEA-PPQPPPLSTQPPQGPPEAQlQPAPQPQVQRPPR-----PQSPTQLL 213
Cdd:TIGR01628  383 RQLPMGSPMGGAMGQPPYYGQGPQQQFNGQPLGwPRMSMMPTPMGPGGPLRPN-GLAPMNAVRAPSRnaqnaAQKPPMQP 461

                           90       100
                   ....*....|....*....|...
gi 2462613565  214 HQNLPPVQAHPSAQSLSQPLSAY 236
Cdd:TIGR01628  462 VMYPPNYQSLPLSQDLPQPQSTA 484
PTZ00121 PTZ00121
MAEBL; Provisional
 663-826 5.46e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 5.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  663 KDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHL-P 741
Cdd:PTZ00121  1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKkA 1440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  742 EKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKgEPAYENPKKSSEVKVKEERKEDHDLPPEAP 821
Cdd:PTZ00121  1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK-KKAEEAKKKADEAKKAAEAKKKADEAKKAE 1519


                   ....*
gi 2462613565  822 QTHRA 826
Cdd:PTZ00121  1520 EAKKA 1524
 
Name Accession Description Interval E-value
Auts2 pfam15336
Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family ...
 469-681 1.37e-82

Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.


Pssm-ID: 464656  Cd Length: 217  Bit Score: 267.48  E-value: 1.37e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  469 KPGKWCAMHVHIAWQIYHHQQKVKkQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTP 548
Cdd:pfam15336    1 KPGKWCAMHVRIAWQIYHHQQKVK-QMQLDPHKLDVGLKLELLSRPPGPGVFGGFPYPHDLARPATLFSATGAAHPSATP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  549 FGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHRTPPSFP 628
Cdd:pfam15336   80 FGPSPPHGSFLSPASHLDPFSRPSTFGGLGALSSGAFGGLGSPSLTANSVFGHKEGPPLQGFSSPHDPWNRLHRTPPSFP 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462613565  629 TPPPWLKPGELERSASAAAHDRDRDVDKRD----SSVSKDDKERESVEK-RHSSHPSP 681
Cdd:pfam15336  160 TPPPWPKPGDAERSSSLESHERERDRERERekrdSSVIKDEKDRDSLDKnRHSSRSSP 217
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 142-279 2.52e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 61.59  E-value: 2.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  142 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPlstQPPQGPPEAQLQ-PAPQPQVQRPPRPQSPTQLLHQNLPPV 220
Cdd:pfam09770  219 AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQ---HPGQGHPVTILQrPQSPQPDPAQPSIQPQAQQFHQQPPPV 295

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  221 QAHPSaQSLSQPlsaynsSSLSLNSLSSRSSTPAKTQPAPPHISHH-PSASPFPLSLPNH 279
Cdd:pfam09770  296 PVQPT-QILQNP------NRLSAARVGYPQNPQPGVQPAPAHQAHRqQGSFGRQAPIITH 348
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 140-325 1.83e-08

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 58.51  E-value: 1.83e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  140 PCPQV-AQPIPQPQT----------EPQLRAPSPDPdlvqrteaPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQS 208
Cdd:pfam09770  175 PAPQPaAQPASLPAPsrkmmsleevEAAMRAQAKKP--------AQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQP 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  209 PTQLLHQNLPPVQAHPsAQSLSQPLSAynssslslnslSSRSSTPAKTQPAPPHISHHPSASPFPLSL---PNHSPLHSF 285
Cdd:pfam09770  247 QQQPQQPQQHPGQGHP-VTILQRPQSP-----------QPDPAQPSIQPQAQQFHQQPPPVPVQPTQIlqnPNRLSAARV 314

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2462613565  286 tPTLQPPAHSHHPNmfaPPTALPPPPPLTSGSLQVAGHPA 325
Cdd:pfam09770  315 -GYPQNPQPGVQPA---PAHQAHRQQGSFGRQAPIITHPQ 350
PHA03247 PHA03247
large tegument protein UL36; Provisional
 140-297 8.02e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 8.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  140 PCPQVAQPIPQPQTEPQLRAPSPdpdlvqrteAPPQPPPLSTQPPQgpPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPP 219
Cdd:PHA03247  2882 PVRRLARPAVSRSTESFALPPDQ---------PERPPQPQAPPPPQ--PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA 2950

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  220 VQAHPSAQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLH--------SFTPTLQP 291
Cdd:PHA03247  2951 GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHeetdpppvSLKQTLWP 3030


                   ....*.
gi 2462613565  292 PAHSHH 297
Cdd:PHA03247  3031 PDDTED 3036
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 129-233 9.03e-08

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 56.63  E-value: 9.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  129 EPIFEPVVLKDPCP-----------QVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQgppeaqlQPAPQ 197
Cdd:PRK10263   742 EPLFTPIVEPVQQPqqpvapqqqyqQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQ-------PVAPQ 814

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462613565  198 PQVQRPPRPQSPTQLLHQNLPPVQAHPSaQSLSQPL 233
Cdd:PRK10263   815 PQYQQPQQPVAPQPQYQQPQQPVAPQPQ-DTLLHPL 849
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 99-296 1.25e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 55.93  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565   99 PEHDSQDAGPIVPKISGLERSQEKSQDCCKEPIFE--PVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPdlvQRTEAPPQP 176
Cdd:pfam03154  134 PKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQtqPPVLQAQSGAASPPSPPPPGTTQAATAGPTP---SAPSVPPQG 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  177 PPLSTQPPQGP-----PEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAhpSAQSLSQPlsaynssslslNSLSSRSS 251
Cdd:pfam03154  211 SPATSQPPNQTqstaaPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQV--SPQPLPQP-----------SLHGQMPP 277

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 2462613565  252 TPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSH 296
Cdd:pfam03154  278 MPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQ 322
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 140-332 3.85e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 54.27  E-value: 3.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  140 PCPQVAQPIPQPQTEPQ--------LRAPSPDPDL----------VQRTEAPPQPPPLSTQPPQGPP-----------EA 190
Cdd:pfam09770  122 SLPQYQYASQQSQQPSKpvrtgyekYKEPEPIPDLqvdaslwgvaPKKAAAPAPAPQPAAQPASLPApsrkmmsleevEA 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  191 QL-----QPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSsslslnslssrsstPAKTQPAPPHISH 265
Cdd:pfam09770  202 AMraqakKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQ--------------QHPGQGHPVTILQ 267

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462613565  266 HPSASPFPLSLPNHSPLHSFTPTLQPPAHSH------HPNMFAPPTALPPPPPLTsGSLQVAGHPAGSTYSEQ 332
Cdd:pfam09770  268 RPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQptqilqNPNRLSAARVGYPQNPQP-GVQPAPAHQAHRQQGSF 339
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 145-261 7.60e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 53.33  E-value: 7.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  145 AQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLL--HQNLPPVQA 222
Cdd:PRK07994   362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQraQGATKAKKS 441

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2462613565  223 HPSAQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPP 261
Cdd:PRK07994   442 EPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYR 480
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 129-298 7.82e-07

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 53.55  E-value: 7.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  129 EPIFEPVVLKDPCPQVAQPIPQPqTEPQLRAPSpdpdlVQRTEAPPQPPPLSTQPPQGP--PEAQLQPAPQ--PQVQRPP 204
Cdd:PRK10263   314 APITEPVAVAAAATTATQSWAAP-VEPVTQTPP-----VASVDVPPAQPTVAWQPVPGPqtGEPVIAPAPEgyPQQSQYA 387

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  205 RPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHS 284
Cdd:PRK10263   388 QPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQT 467

                          170
                   ....*....|....*
gi 2462613565  285 FT-PTLQPPAHSHHP 298
Cdd:PRK10263   468 YQqPAAQEPLYQQPQ 482
PHA03247 PHA03247
large tegument protein UL36; Provisional
 113-446 1.91e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  113 ISGLErsQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPqtepqlrAPSPDPDLVQRTEAPPQPPPLSTQP-----PQGP 187
Cdd:PHA03247  2537 IRGLE--ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRP-------APRPSEPAVTSRARRPDAPPQSARPrapvdDRGD 2607

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  188 PEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQpAPPHISHHP 267
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS-SPPQRPRRR 2686

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  268 SASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVA--GHPAGSTYSEQDILRQELNTRFLA 345
Cdd:PHA03247  2687 AARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAppAVPAGPATPGGPARPARPPTTAGP 2766

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  346 SQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMVRTPGrnfdkyPTKVDPfyrh 425
Cdd:PHA03247  2767 PAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP------PTSAQP---- 2836

                          330       340
                   ....*....|....*....|.
gi 2462613565  426 slfhSYPPAVSGIPPMIPPTG 446
Cdd:PHA03247  2837 ----TAPPPPPGPPPPSLPLG 2853
PHA03247 PHA03247
large tegument protein UL36; Provisional
 140-298 2.19e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 2.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  140 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQR---------TEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPT 210
Cdd:PHA03247  2836 PTAPPPPPGPPPPSLPLGGSVAPGGDVRRRppsrspaakPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPP 2915

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  211 QLLHQNLPPVQAHPSAQSLSQPLSaynSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQ 290
Cdd:PHA03247  2916 PPQPQPQPPPPPQPQPPPPPPPRP---QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992


                   ....*...
gi 2462613565  291 PPAHSHHP 298
Cdd:PHA03247  2993 TPPLTGHS 3000
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 142-276 1.49e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 48.94  E-value: 1.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  142 PQVAQPIPQP-QTEPQLRAPSPDPDlvqrteAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHqnlPPV 220
Cdd:PRK14951   366 PAAAAEAAAPaEKKTPARPEAAAPA------AAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAA---PAA 436

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613565  221 QAHPSAQSLSQPLSAYNSSSLSLNSLSSR-SSTPAKTQPAPPHISHHPSASPFPLSL 276
Cdd:PRK14951   437 APAAAPAAVALAPAPPAQAAPETVAIPVRvAPEPAVASAAPAPAAAPAAARLTPTEE 493
PHA03247 PHA03247
large tegument protein UL36; Provisional
 99-277 3.19e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565   99 PEHDSQDAGPIVPKISGLERSQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPP 178
Cdd:PHA03247  2766 PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  179 LST----------------QPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLS 242
Cdd:PHA03247  2846 PPPslplggsvapggdvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP 2925

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 2462613565  243 LNSLSSRSSTPAKTQPAPPhishhPSASPFPLSLP 277
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLA-----PTTDPAGAGEP 2955
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 142-231 1.02e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.57  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  142 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQllhqnLPPVQ 221
Cdd:pfam09770  272 PQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGR-----QAPII 346

                           90
                   ....*....|
gi 2462613565  222 AHPsaQSLSQ 231
Cdd:pfam09770  347 THP--QQLAQ 354
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 140-236 1.57e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.57  E-value: 1.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  140 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEA-PPQPPPLSTQPPQGPPEAQlQPAPQPQVQRPPR-----PQSPTQLL 213
Cdd:TIGR01628  383 RQLPMGSPMGGAMGQPPYYGQGPQQQFNGQPLGwPRMSMMPTPMGPGGPLRPN-GLAPMNAVRAPSRnaqnaAQKPPMQP 461

                           90       100
                   ....*....|....*....|...
gi 2462613565  214 HQNLPPVQAHPSAQSLSQPLSAY 236
Cdd:TIGR01628  462 VMYPPNYQSLPLSQDLPQPQSTA 484
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 130-220 5.29e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 44.03  E-value: 5.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  130 PIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPdlvqrtEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSP 209
Cdd:PRK14950   364 PAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIP------PKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIP 437

                           90
                   ....*....|.
gi 2462613565  210 TQLLHQNLPPV 220
Cdd:PRK14950   438 VDEKPKYTPPA 448
PTZ00121 PTZ00121
MAEBL; Provisional
 663-826 5.46e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 5.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  663 KDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHL-P 741
Cdd:PTZ00121  1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKkA 1440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  742 EKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKgEPAYENPKKSSEVKVKEERKEDHDLPPEAP 821
Cdd:PTZ00121  1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK-KKAEEAKKKADEAKKAAEAKKKADEAKKAE 1519


                   ....*
gi 2462613565  822 QTHRA 826
Cdd:PTZ00121  1520 EAKKA 1524
PHA03247 PHA03247
large tegument protein UL36; Provisional
 134-293 6.80e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 6.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  134 PVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLL 213
Cdd:PHA03247  2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  214 HQNLPPVQAHPSAqslsqPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPL--SLPNHSPLHSFTPTLQP 291
Cdd:PHA03247  2797 SLPSPWDPADPPA-----AVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggSVAPGGDVRRRPPSRSP 2871


                   ..
gi 2462613565  292 PA 293
Cdd:PHA03247  2872 AA 2873
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 147-278 7.01e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 43.56  E-value: 7.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  147 PIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSA 226
Cdd:PHA03269    27 PIPELHTSAATQKPDPAPAPHQAASRAPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLAA 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462613565  227 QSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPP-HISHHPSASPFPLSLPN 278
Cdd:PHA03269   107 APKPDAAEAFTSAAQAHEAPADAGTSAASKKPDPAaHTQHSPPPFAYTRSMEH 159
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 134-298 9.41e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 9.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  134 PVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQ-LQPAP--QPQVQRPPR---PQ 207
Cdd:pfam03154  286 PSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQpLPPAPlsMPHIKPPPTtpiPQ 365

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  208 SPTQLLHQ---------------NLPPVQAHPSAQSLS--QPLSAYNSSSLSLNSLSSRSSTPAKtqpaPPHISHHPSAS 270
Cdd:pfam03154  366 LPNPQSHKhpphlsgpspfqmnsNLPPPPALKPLSSLSthHPPSAHPPPLQLMPQSQQLPPPPAQ----PPVLTQSQSLP 441

                          170       180
                   ....*....|....*....|....*...
gi 2462613565  271 PFPLSLPNHSPLHSFTPTLQPPAHSHHP 298
Cdd:pfam03154  442 PPAASHPPTSGLHQVPSQSPFPQHPFVP 469
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 104-206 1.07e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.15  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  104 QDAGPIVPKISGLERSQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAP-PQP---PPL 179
Cdd:PRK10263   398 QQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTyQQPaaqEPL 477

                           90       100
                   ....*....|....*....|....*..
gi 2462613565  180 STQPPQGPPEAQLQPAPQPQVQRPPRP 206
Cdd:PRK10263   478 YQQPQPVEQQPVVEPEPVVEETKPARP 504
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 142-211 1.08e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.08e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  142 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQ 211
Cdd:PRK07764   430 QPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAA 499
PRK10819 PRK10819
transport protein TonB; Provisional
 142-261 1.26e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 41.98  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  142 PQVAQPI------PQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQP-----PQGPPEAQLQPAPQPQVQRPPRPqspt 210
Cdd:PRK10819    42 PAPAQPIsvtmvaPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPvvipkPEPKPKPKPKPKPKPVKKVEEQP---- 117

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462613565  211 qllHQNLPPVQAHPsaqslSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPP 261
Cdd:PRK10819   118 ---KREVKPVEPRP-----ASPFENTAPARPTSSTATAAASKPVTSVSSGP 160
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
142-225 1.35e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.84  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  142 PQVAQPIPQPQTEPQlRAPSPDPDLVQRTEAPPQPPPLSTQ---PPQGpPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLP 218
Cdd:PRK14971   381 PVFTQPAAAPQPSAA-AAASPSPSQSSAAAQPSAPQSATQPagtPPTV-SVDPPAAVPVNPPSTAPQAVRPAQFKEEKKI 458


                   ....*..
gi 2462613565  219 PVQAHPS 225
Cdd:PRK14971   459 PVSKVSS 465
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 161-273 1.37e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.76  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  161 SPDPDLVQrtEAPPQPPPLSTQPPQGPPEAQLQPAPQPQV-QRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSS 239
Cdd:PRK10263   730 SPMKALLD--DGPHEPLFTPIVEPVQQPQQPVAPQQQYQQpQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQP 807

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2462613565  240 SLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFP 273
Cdd:PRK10263   808 QQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQP 841
PRK11633 PRK11633
cell division protein DedD; Provisional
 139-209 1.62e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 41.14  E-value: 1.62e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462613565  139 DPCPQVAQPIP-QP----QTEPQLR---APSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSP 209
Cdd:PRK11633    54 DMMPAATQALPtQPpegaAEAVRAGdaaAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAPPAPK 132
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
129-301 1.97e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  129 EPIFEPVVLKDPCPQVAQPIPQPQTEPQLRAP---SPDPDLVQ-----------RTEAPPQPPPLSTQPPQGPPEAQLQP 194
Cdd:PRK12323   392 PAAAAPAPAAPPAAPAAAPAAAAAARAVAAAParrSPAPEALAaarqasargpgGAPAPAPAPAAAPAAAARPAAAGPRP 471

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  195 APQPQVQRPPRPQSPTQLLHQ--NLPPVQAHPSAQSLSQPlsaYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPF 272
Cdd:PRK12323   472 VAAAAAAAPARAAPAAAPAPAddDPPPWEELPPEFASPAP---AQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAA 548

                          170       180
                   ....*....|....*....|....*....
gi 2462613565  273 PLSLPNHSPLHSFTPTLQPPAHSHHPNMF 301
Cdd:PRK12323   549 PAPRAAAATEPVVAPRPPRASASGLPDMF 577
PRK12757 PRK12757
cell division protein FtsN; Provisional
 144-211 2.01e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 41.18  E-value: 2.01e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462613565  144 VAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGP-PEAQLQPAPQPQVQRPPRPQSPTQ 211
Cdd:PRK12757   112 PQVPRSTVQIQQQAQQQQPPATTAQPQPVTPPRQTTAPVQPQTPaPVRTQPAAPVTQAVEAPKVEAEKE 180
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 140-227 2.17e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 2.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  140 PCPQVAQPIPQPQTePQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQlQPAPQPQVQRPPRPQSPTQLLHQNLPP 219
Cdd:PRK07764   406 PAAAPAPAAAAPAA-AAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSP-PPAAAPSAQPAPAPAAAPEPTAAPAPA 483


                   ....*...
gi 2462613565  220 VQAHPSAQ 227
Cdd:PRK07764   484 PPAAPAPA 491
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 131-261 2.17e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.10  E-value: 2.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  131 IFEPVVLKDPCPQVAQPipqpqtepqlRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPqvqrPPRPQSPt 210
Cdd:PRK14950   355 VIEALLVPVPAPQPAKP----------TAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPV----PPRPVAP- 419

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462613565  211 qllhqnlPPVQAHPSAQSLSqplsaynssslslNSLSSRSSTPAKTQPAPP 261
Cdd:PRK14950   420 -------PVPHTPESAPKLT-------------RAAIPVDEKPKYTPPAPP 450
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 140-232 5.36e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 40.23  E-value: 5.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  140 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAP-PQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLP 218
Cdd:PHA02682   103 PAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPaPACPPSTRQCPPAPPLPTPKPAPAAKPIFLHNQLPPPDYPAASCP 182

                           90
                   ....*....|....
gi 2462613565  219 PVQAHPSAQSLSQP 232
Cdd:PHA02682   183 TIETAPAASPVLEP 196
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 130-234 5.39e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 40.86  E-value: 5.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  130 PIFEPVVLKDPCPQVAQPIPQPQTEPQLR-----APSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPP 204
Cdd:PRK14949   681 LATHQSVPEAALASGSAPAPPPVPDPYDRppweeAPEVASANDGPNNAAEGNLSESVEDASNSELQAVEQQATHQPQVQA 760

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2462613565  205 RPQSPTQ---LLHQNLPPVQAHPS-AQSLSQPLS 234
Cdd:PRK14949   761 EAQSPASttaLTQTSSEVQDTELNlVLLSSGSIT 794
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 150-212 5.84e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 40.67  E-value: 5.84e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462613565  150 QPQTEPQLRAPSPDPdlvqRTEAPPQPPPLSTQPPQGPPEAQLQPAP-QPQVQRPPRPQSPTQL 212
Cdd:PRK01297    16 QPAPAPPSPAAAPAP----PPPAKTAAPATKAAAPAAAAPRAEKPKKdKPRRERKPKPASLWKL 75
DUF6264 pfam19779
Family of unknown function (DUF6264); This family of putative integral membrane proteins is ...
 153-206 5.92e-03

Family of unknown function (DUF6264); This family of putative integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 179 and 218 amino acids in length.


Pssm-ID: 466182  Cd Length: 182  Bit Score: 39.17  E-value: 5.92e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462613565  153 TEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGP-------PEAQLQPAPQPQVQRPPRP 206
Cdd:pfam19779    9 PPGWQRAPIGDPAAAAAAAPPAAPAPAAPAPPAAPaappaapPPPGAPAPGAPAAARRARR 69
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
140-232 6.34e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.53  E-value: 6.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  140 PCPQVAQPIPQPQ-TEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQspTQLLHQNLP 218
Cdd:PRK14971   409 AQPSAPQSATQPAgTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQEK--AEQATGNIK 486

                           90
                   ....*....|....
gi 2462613565  219 PVQAHPSAQSLSQP 232
Cdd:PRK14971   487 EAPTGTQKEIFTEE 500
PRK10819 PRK10819
transport protein TonB; Provisional
 128-232 7.14e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 39.28  E-value: 7.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  128 KEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRaPSPDPDLVQRTEAPPQPP--PLSTQPPQ-GPPEAQLQPAPQPQVQRPP 204
Cdd:PRK10819    72 VEPEPEPEPIPEPPKEAPVVIPKPEPKPKPK-PKPKPKPVKKVEEQPKREvkPVEPRPASpFENTAPARPTSSTATAAAS 150

                           90       100
                   ....*....|....*....|....*...
gi 2462613565  205 RPQSptqllhqnlpPVQAHPSAQSLSQP 232
Cdd:PRK10819   151 KPVT----------SVSSGPRALSRNQP 168
PHA03378 PHA03378
EBNA-3B; Provisional
 147-234 7.83e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 7.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  147 PIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSA 226
Cdd:PHA03378   743 RARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTK 822


                   ....*...
gi 2462613565  227 QSLSQPLS 234
Cdd:PHA03378   823 QILRQLLT 830
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 145-235 8.58e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 8.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  145 AQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPtqllhqnlPPVQAHP 224
Cdd:PRK07764   429 PQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAA--------PAAPAAP 500

                           90
                   ....*....|.
gi 2462613565  225 SAQSLSQPLSA 235
Cdd:PRK07764   501 AAPAGADDAAT 511
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 168-288 9.76e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 9.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613565  168 QRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPR---------PQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNS 238
Cdd:pfam03154  422 QQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQspfpqhpfvPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVS 501

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613565  239 SSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPT 288
Cdd:pfam03154  502 SSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTPS 551
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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