|
Name |
Accession |
Description |
Interval |
E-value |
| Auts2 |
pfam15336 |
Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family ... |
605-817 |
2.45e-83 |
|
Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.
Pssm-ID: 464656 Cd Length: 217 Bit Score: 270.94 E-value: 2.45e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 605 KPGKWCAMHVHIAWQIYHHQQKVKkQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTP 684
Cdd:pfam15336 1 KPGKWCAMHVRIAWQIYHHQQKVK-QMQLDPHKLDVGLKLELLSRPPGPGVFGGFPYPHDLARPATLFSATGAAHPSATP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 685 FGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHRTPPSFP 764
Cdd:pfam15336 80 FGPSPPHGSFLSPASHLDPFSRPSTFGGLGALSSGAFGGLGSPSLTANSVFGHKEGPPLQGFSSPHDPWNRLHRTPPSFP 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2462613545 765 TPPPWLKPGELERSASAAAHDRDRDVDKRD----SSVSKDDKERESVEK-RHSSHPSP 817
Cdd:pfam15336 160 TPPPWPKPGDAERSSSLESHERERDRERERekrdSSVIKDEKDRDSLDKnRHSSRSSP 217
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
300-437 |
2.51e-09 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 61.59 E-value: 2.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 300 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPlstQPPQGPPEAQLQ-PAPQPQVQRPPRPQSPTQLLHQNLPPV 378
Cdd:pfam09770 219 AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQ---HPGQGHPVTILQrPQSPQPDPAQPSIQPQAQQFHQQPPPV 295
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 379 QAHPSaQSLSQPlsaynsSSLSLNSLSSRSSTPAKTQPAPPHISHH-PSASPFPLSLPNH 437
Cdd:pfam09770 296 PVQPT-QILQNP------NRLSAARVGYPQNPQPGVQPAPAHQAHRqQGSFGRQAPIITH 348
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
271-655 |
1.08e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 59.95 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 271 ISGLErsQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPqtepqlrAPSPDPDLVQRTEAPPQPPPLSTQP-----PQGP 345
Cdd:PHA03247 2537 IRGLE--ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRP-------APRPSEPAVTSRARRPDAPPQSARPrapvdDRGD 2607
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 346 PEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQpAPPHISHHP 425
Cdd:PHA03247 2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS-SPPQRPRRR 2686
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 426 SASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVA--GHPAGSTYSEQDILRQELNTRFLA 503
Cdd:PHA03247 2687 AARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAppAVPAGPATPGGPARPARPPTTAGP 2766
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 504 SQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMLFHSYPPAVSGIPPMIP--PT 581
Cdd:PHA03247 2767 PAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPpgPP 2846
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462613545 582 GPFGSLQGAFQPKLTDPFRPMLRKPGKWCAMHVHIAWQIYhHQQKVKKQMQSdphkldFGLKPEFLSRPPGPSL 655
Cdd:PHA03247 2847 PPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRL-ARPAVSRSTES------FALPPDQPERPPQPQA 2913
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
298-483 |
1.87e-08 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 58.89 E-value: 1.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 298 PCPQV-AQPIPQPQT----------EPQLRAPSPDPdlvqrteaPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQS 366
Cdd:pfam09770 175 PAPQPaAQPASLPAPsrkmmsleevEAAMRAQAKKP--------AQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQP 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 367 PTQLLHQNLPPVQAHPsAQSLSQPLSAynssslslnslSSRSSTPAKTQPAPPHISHHPSASPFPLSL---PNHSPLHSF 443
Cdd:pfam09770 247 QQQPQQPQQHPGQGHP-VTILQRPQSP-----------QPDPAQPSIQPQAQQFHQQPPPVPVQPTQIlqnPNRLSAARV 314
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 2462613545 444 tPTLQPPAHSHHPNmfaPPTALPPPPPLTSGSLQVAGHPA 483
Cdd:pfam09770 315 -GYPQNPQPGVQPA---PAHQAHRQQGSFGRQAPIITHPQ 350
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
257-454 |
5.56e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 57.47 E-value: 5.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 257 PEHDSQDAGPIVPKISGLERSQEKSQDCCKEPIFE--PVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPdlvQRTEAPPQP 334
Cdd:pfam03154 134 PKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQtqPPVLQAQSGAASPPSPPPPGTTQAATAGPTP---SAPSVPPQG 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 335 PPLSTQPPQGP-----PEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAhpSAQSLSQPlsaynssslslNSLSSRSS 409
Cdd:pfam03154 211 SPATSQPPNQTqstaaPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQV--SPQPLPQP-----------SLHGQMPP 277
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2462613545 410 TPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSH 454
Cdd:pfam03154 278 MPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQ 322
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
298-455 |
6.15e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 57.64 E-value: 6.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 298 PCPQVAQPIPQPQTEPQLRAPSPdpdlvqrteAPPQPPPLSTQPPQgpPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPP 377
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQ---------PERPPQPQAPPPPQ--PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA 2950
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 378 VQAHPSAQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLH--------SFTPTLQP 449
Cdd:PHA03247 2951 GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHeetdpppvSLKQTLWP 3030
|
....*.
gi 2462613545 450 PAHSHH 455
Cdd:PHA03247 3031 PDDTED 3036
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
287-391 |
6.69e-08 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 57.40 E-value: 6.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 287 EPIFEPVVLKDPCP-----------QVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQgppeaqlQPAPQ 355
Cdd:PRK10263 742 EPLFTPIVEPVQQPqqpvapqqqyqQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQ-------PVAPQ 814
|
90 100 110
....*....|....*....|....*....|....*.
gi 2462613545 356 PQVQRPPRPQSPTQLLHQNLPPVQAHPSaQSLSQPL 391
Cdd:PRK10263 815 PQYQQPQQPVAPQPQYQQPQQPVAPQPQ-DTLLHPL 849
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
298-490 |
3.92e-07 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 54.66 E-value: 3.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 298 PCPQVAQPIPQPQTEPQ--------LRAPSPDPDL----------VQRTEAPPQPPPLSTQPPQGPP-----------EA 348
Cdd:pfam09770 122 SLPQYQYASQQSQQPSKpvrtgyekYKEPEPIPDLqvdaslwgvaPKKAAAPAPAPQPAAQPASLPApsrkmmsleevEA 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 349 QL-----QPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSsslslnslssrsstPAKTQPAPPHISH 423
Cdd:pfam09770 202 AMraqakKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQ--------------QHPGQGHPVTILQ 267
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462613545 424 HPSASPFPLSLPNHSPLHSFTPTLQPPAHSH------HPNMFAPPTALPPPPPLTsGSLQVAGHPAGSTYSEQ 490
Cdd:pfam09770 268 RPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQptqilqNPNRLSAARVGYPQNPQP-GVQPAPAHQAHRQQGSF 339
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
287-456 |
6.08e-07 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 53.94 E-value: 6.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 287 EPIFEPVVLKDPCPQVAQPIPQPqTEPQLRAPSpdpdlVQRTEAPPQPPPLSTQPPQGP--PEAQLQPAPQ--PQVQRPP 362
Cdd:PRK10263 314 APITEPVAVAAAATTATQSWAAP-VEPVTQTPP-----VASVDVPPAQPTVAWQPVPGPqtGEPVIAPAPEgyPQQSQYA 387
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 363 RPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHS 442
Cdd:PRK10263 388 QPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQT 467
|
170
....*....|....*
gi 2462613545 443 FT-PTLQPPAHSHHP 456
Cdd:PRK10263 468 YQqPAAQEPLYQQPQ 482
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
303-419 |
1.01e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 52.95 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 303 AQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLL--HQNLPPVQA 380
Cdd:PRK07994 362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQraQGATKAKKS 441
|
90 100 110
....*....|....*....|....*....|....*....
gi 2462613545 381 HPSAQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPP 419
Cdd:PRK07994 442 EPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYR 480
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
298-456 |
1.93e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 52.63 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 298 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQR---------TEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPT 368
Cdd:PHA03247 2836 PTAPPPPPGPPPPSLPLGGSVAPGGDVRRRppsrspaakPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPP 2915
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 369 QLLHQNLPPVQAHPSAQSLSQPLSaynSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQ 448
Cdd:PHA03247 2916 PPQPQPQPPPPPQPQPPPPPPPRP---QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992
|
....*...
gi 2462613545 449 PPAHSHHP 456
Cdd:PHA03247 2993 TPPLTGHS 3000
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
300-434 |
1.68e-05 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 48.94 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 300 PQVAQPIPQP-QTEPQLRAPSPDPDlvqrteAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHqnlPPV 378
Cdd:PRK14951 366 PAAAAEAAAPaEKKTPARPEAAAPA------AAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAA---PAA 436
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613545 379 QAHPSAQSLSQPLSAYNSSSLSLNSLSSR-SSTPAKTQPAPPHISHHPSASPFPLSL 434
Cdd:PRK14951 437 APAAAPAAVALAPAPPAQAAPETVAIPVRvAPEPAVASAAPAPAAAPAAARLTPTEE 493
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
257-435 |
2.52e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.78 E-value: 2.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 257 PEHDSQDAGPIVPKISGLERSQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPP 336
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 337 LST----------------QPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLS 400
Cdd:PHA03247 2846 PPPslplggsvapggdvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP 2925
|
170 180 190
....*....|....*....|....*....|....*
gi 2462613545 401 LNSLSSRSSTPAKTQPAPPhishhPSASPFPLSLP 435
Cdd:PHA03247 2926 PPQPQPPPPPPPRPQPPLA-----PTTDPAGAGEP 2955
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
300-389 |
1.04e-04 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 46.57 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 300 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQllhqnLPPVQ 379
Cdd:pfam09770 272 PQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGR-----QAPII 346
|
90
....*....|
gi 2462613545 380 AHPsaQSLSQ 389
Cdd:pfam09770 347 THP--QQLAQ 354
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
298-394 |
1.95e-04 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 45.57 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 298 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEA-PPQPPPLSTQPPQGPPEAQlQPAPQPQVQRPPR-----PQSPTQLL 371
Cdd:TIGR01628 383 RQLPMGSPMGGAMGQPPYYGQGPQQQFNGQPLGwPRMSMMPTPMGPGGPLRPN-GLAPMNAVRAPSRnaqnaAQKPPMQP 461
|
90 100
....*....|....*....|...
gi 2462613545 372 HQNLPPVQAHPSAQSLSQPLSAY 394
Cdd:TIGR01628 462 VMYPPNYQSLPLSQDLPQPQSTA 484
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
292-456 |
4.40e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 44.76 E-value: 4.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 292 PVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQ-LQPAP--QPQVQRPPR---PQ 365
Cdd:pfam03154 286 PSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQpLPPAPlsMPHIKPPPTtpiPQ 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 366 SPTQLLHQ---------------NLPPVQAHPSAQSLS--QPLSAYNSSSLSLNSLSSRSSTPAKtqpaPPHISHHPSAS 428
Cdd:pfam03154 366 LPNPQSHKhpphlsgpspfqmnsNLPPPPALKPLSSLSthHPPSAHPPPLQLMPQSQQLPPPPAQ----PPVLTQSQSLP 441
|
170 180
....*....|....*....|....*...
gi 2462613545 429 PFPLSLPNHSPLHSFTPTLQPPAHSHHP 456
Cdd:pfam03154 442 PPAASHPPTSGLHQVPSQSPFPQHPFVP 469
|
|
| PHA03269 |
PHA03269 |
envelope glycoprotein C; Provisional |
305-436 |
5.29e-04 |
|
envelope glycoprotein C; Provisional
Pssm-ID: 165527 [Multi-domain] Cd Length: 566 Bit Score: 44.33 E-value: 5.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 305 PIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSA 384
Cdd:PHA03269 27 PIPELHTSAATQKPDPAPAPHQAASRAPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLAA 106
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2462613545 385 QSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPP-HISHHPSASPFPLSLPN 436
Cdd:PHA03269 107 APKPDAAEAFTSAAQAHEAPADAGTSAASKKPDPAaHTQHSPPPFAYTRSMEH 159
|
|
| PRK14950 |
PRK14950 |
DNA polymerase III subunits gamma and tau; Provisional |
288-378 |
6.07e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 44.03 E-value: 6.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 288 PIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPdlvqrtEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSP 367
Cdd:PRK14950 364 PAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIP------PKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIP 437
|
90
....*....|.
gi 2462613545 368 TQLLHQNLPPV 378
Cdd:PRK14950 438 VDEKPKYTPPA 448
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
799-962 |
6.27e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 44.36 E-value: 6.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 799 KDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHL-P 877
Cdd:PTZ00121 1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKkA 1440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 878 EKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKgEPAYENPKKSSEVKVKEERKEDHDLPPEAP 957
Cdd:PTZ00121 1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK-KKAEEAKKKADEAKKAAEAKKKADEAKKAE 1519
|
....*
gi 2462613545 958 QTHRA 962
Cdd:PTZ00121 1520 EAKKA 1524
|
|
| PRK10819 |
PRK10819 |
transport protein TonB; Provisional |
300-419 |
7.16e-04 |
|
transport protein TonB; Provisional
Pssm-ID: 236768 [Multi-domain] Cd Length: 246 Bit Score: 42.75 E-value: 7.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 300 PQVAQPI------PQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQP-----PQGPPEAQLQPAPQPQVQRPPRPqspt 368
Cdd:PRK10819 42 PAPAQPIsvtmvaPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPvvipkPEPKPKPKPKPKPKPVKKVEEQP---- 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2462613545 369 qllHQNLPPVQAHPsaqslSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPP 419
Cdd:PRK10819 118 ---KREVKPVEPRP-----ASPFENTAPARPTSSTATAAASKPVTSVSSGP 160
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
262-364 |
9.01e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 43.54 E-value: 9.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 262 QDAGPIVPKISGLERSQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAP-PQP---PPL 337
Cdd:PRK10263 398 QQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTyQQPaaqEPL 477
|
90 100
....*....|....*....|....*..
gi 2462613545 338 STQPPQGPPEAQLQPAPQPQVQRPPRP 364
Cdd:PRK10263 478 YQQPQPVEQQPVVEPEPVVEETKPARP 504
|
|
| PRK11633 |
PRK11633 |
cell division protein DedD; Provisional |
297-367 |
1.02e-03 |
|
cell division protein DedD; Provisional
Pssm-ID: 236940 [Multi-domain] Cd Length: 226 Bit Score: 41.91 E-value: 1.02e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462613545 297 DPCPQVAQPIP-QP----QTEPQLR---APSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSP 367
Cdd:PRK11633 54 DMMPAATQALPtQPpegaAEAVRAGdaaAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAPPAPK 132
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
300-369 |
1.10e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.44 E-value: 1.10e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 300 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQ 369
Cdd:PRK07764 430 QPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAA 499
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
319-431 |
1.17e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 43.54 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 319 SPDPDLVQrtEAPPQPPPLSTQPPQGPPEAQLQPAPQPQV-QRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSS 397
Cdd:PRK10263 730 SPMKALLD--DGPHEPLFTPIVEPVQQPQQPVAPQQQYQQpQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQP 807
|
90 100 110
....*....|....*....|....*....|....
gi 2462613545 398 SLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFP 431
Cdd:PRK10263 808 QQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQP 841
|
|
| PRK14971 |
PRK14971 |
DNA polymerase III subunit gamma/tau; |
300-383 |
1.63e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 42.46 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 300 PQVAQPIPQPQTEPQlRAPSPDPDLVQRTEAPPQPPPLSTQ---PPQGpPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLP 376
Cdd:PRK14971 381 PVFTQPAAAPQPSAA-AAASPSPSQSSAAAQPSAPQSATQPagtPPTV-SVDPPAAVPVNPPSTAPQAVRPAQFKEEKKI 458
|
....*..
gi 2462613545 377 PVQAHPS 383
Cdd:PRK14971 459 PVSKVSS 465
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
287-459 |
1.72e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 42.56 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 287 EPIFEPVVLKDPCPQVAQPIPQPQTEPQLRAP---SPDPDLVQ-----------RTEAPPQPPPLSTQPPQGPPEAQLQP 352
Cdd:PRK12323 392 PAAAAPAPAAPPAAPAAAPAAAAAARAVAAAParrSPAPEALAaarqasargpgGAPAPAPAPAAAPAAAARPAAAGPRP 471
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 353 APQPQVQRPPRPQSPTQLLHQ--NLPPVQAHPSAQSLSQPlsaYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPF 430
Cdd:PRK12323 472 VAAAAAAAPARAAPAAAPAPAddDPPPWEELPPEFASPAP---AQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAA 548
|
170 180
....*....|....*....|....*....
gi 2462613545 431 PLSLPNHSPLHSFTPTLQPPAHSHHPNMF 459
Cdd:PRK12323 549 PAPRAAAATEPVVAPRPPRASASGLPDMF 577
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
298-385 |
2.13e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.28 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 298 PCPQVAQPIPQPQTePQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQlQPAPQPQVQRPPRPQSPTQLLHQNLPP 377
Cdd:PRK07764 406 PAAAPAPAAAAPAA-AAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSP-PPAAAPSAQPAPAPAAAPEPTAAPAPA 483
|
....*...
gi 2462613545 378 VQAHPSAQ 385
Cdd:PRK07764 484 PPAAPAPA 491
|
|
| PRK12757 |
PRK12757 |
cell division protein FtsN; Provisional |
302-369 |
2.13e-03 |
|
cell division protein FtsN; Provisional
Pssm-ID: 237191 [Multi-domain] Cd Length: 256 Bit Score: 41.18 E-value: 2.13e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462613545 302 VAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGP-PEAQLQPAPQPQVQRPPRPQSPTQ 369
Cdd:PRK12757 112 PQVPRSTVQIQQQAQQQQPPATTAQPQPVTPPRQTTAPVQPQTPaPVRTQPAAPVTQAVEAPKVEAEKE 180
|
|
| PRK14950 |
PRK14950 |
DNA polymerase III subunits gamma and tau; Provisional |
289-419 |
2.57e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 42.10 E-value: 2.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 289 IFEPVVLKDPCPQVAQPipqpqtepqlRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPqvqrPPRPQSPt 368
Cdd:PRK14950 355 VIEALLVPVPAPQPAKP----------TAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPV----PPRPVAP- 419
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2462613545 369 qllhqnlPPVQAHPSAQSLSqplsaynssslslNSLSSRSSTPAKTQPAPP 419
Cdd:PRK14950 420 -------PVPHTPESAPKLT-------------RAAIPVDEKPKYTPPAPP 450
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
263-598 |
2.61e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.23 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 263 DAGPIVPKISGLERSQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPP 342
Cdd:PHA03247 2621 THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAD 2700
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 343 QGPPEAQLQPAPQPQVQRPPRPQSPtQLLHQNLPPVQAHPSAQSLSQ-----------PLSAYNSSSLSLNSLSSRSSTP 411
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGP-AAARQASPALPAAPAPPAVPAgpatpggparpARPPTTAGPPAPAPPAAPAAGP 2779
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 412 AKTQPAPPHISHHPS--ASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGSTYSE 489
Cdd:PHA03247 2780 PRRLTRPAVASLSESreSLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPG 2859
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 490 QDILRQELNTRFLASQSAD---RGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPmlfhs 566
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAParpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP----- 2934
|
330 340 350
....*....|....*....|....*....|..
gi 2462613545 567 yPPAVSGiPPMIPPTGPFGslQGAFQPKLTDP 598
Cdd:PHA03247 2935 -PPPRPQ-PPLAPTTDPAG--AGEPSGAVPQP 2962
|
|
| PHA02682 |
PHA02682 |
ORF080 virion core protein; Provisional |
298-390 |
3.63e-03 |
|
ORF080 virion core protein; Provisional
Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 41.00 E-value: 3.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 298 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAP-PQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLP 376
Cdd:PHA02682 103 PAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPaPACPPSTRQCPPAPPLPTPKPAPAAKPIFLHNQLPPPDYPAASCP 182
|
90
....*....|....
gi 2462613545 377 PVQAHPSAQSLSQP 390
Cdd:PHA02682 183 TIETAPAASPVLEP 196
|
|
| DUF6264 |
pfam19779 |
Family of unknown function (DUF6264); This family of putative integral membrane proteins is ... |
311-364 |
3.72e-03 |
|
Family of unknown function (DUF6264); This family of putative integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 179 and 218 amino acids in length.
Pssm-ID: 466182 Cd Length: 182 Bit Score: 39.94 E-value: 3.72e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462613545 311 TEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGP-------PEAQLQPAPQPQVQRPPRP 364
Cdd:pfam19779 9 PPGWQRAPIGDPAAAAAAAPPAAPAPAAPAPPAAPaappaapPPPGAPAPGAPAAARRARR 69
|
|
| PRK10819 |
PRK10819 |
transport protein TonB; Provisional |
286-390 |
4.05e-03 |
|
transport protein TonB; Provisional
Pssm-ID: 236768 [Multi-domain] Cd Length: 246 Bit Score: 40.44 E-value: 4.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 286 KEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRaPSPDPDLVQRTEAPPQPP--PLSTQPPQ-GPPEAQLQPAPQPQVQRPP 362
Cdd:PRK10819 72 VEPEPEPEPIPEPPKEAPVVIPKPEPKPKPK-PKPKPKPVKKVEEQPKREvkPVEPRPASpFENTAPARPTSSTATAAAS 150
|
90 100
....*....|....*....|....*...
gi 2462613545 363 RPQSptqllhqnlpPVQAHPSAQSLSQP 390
Cdd:PRK10819 151 KPVT----------SVSSGPRALSRNQP 168
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
305-392 |
6.50e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 40.82 E-value: 6.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 305 PIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSA 384
Cdd:PHA03378 743 RARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTK 822
|
....*...
gi 2462613545 385 QSLSQPLS 392
Cdd:PHA03378 823 QILRQLLT 830
|
|
| PRK14949 |
PRK14949 |
DNA polymerase III subunits gamma and tau; Provisional |
288-392 |
6.61e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237863 [Multi-domain] Cd Length: 944 Bit Score: 40.86 E-value: 6.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 288 PIFEPVVLKDPCPQVAQPIPQPQTEPQLR-----APSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPP 362
Cdd:PRK14949 681 LATHQSVPEAALASGSAPAPPPVPDPYDRppweeAPEVASANDGPNNAAEGNLSESVEDASNSELQAVEQQATHQPQVQA 760
|
90 100 110
....*....|....*....|....*....|....
gi 2462613545 363 RPQSPTQ---LLHQNLPPVQAHPS-AQSLSQPLS 392
Cdd:PRK14949 761 EAQSPASttaLTQTSSEVQDTELNlVLLSSGSIT 794
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
308-370 |
6.80e-03 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 40.28 E-value: 6.80e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462613545 308 QPQTEPQLRAPSPDPdlvqRTEAPPQPPPLSTQPPQGPPEAQLQPAP-QPQVQRPPRPQSPTQL 370
Cdd:PRK01297 16 QPAPAPPSPAAAPAP----PPPAKTAAPATKAAAPAAAAPRAEKPKKdKPRRERKPKPASLWKL 75
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
326-446 |
6.90e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.91 E-value: 6.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 326 QRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPR---------PQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNS 396
Cdd:pfam03154 422 QQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQspfpqhpfvPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVS 501
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2462613545 397 SSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPT 446
Cdd:pfam03154 502 SSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTPS 551
|
|
| PRK14971 |
PRK14971 |
DNA polymerase III subunit gamma/tau; |
298-390 |
7.58e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 40.53 E-value: 7.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 298 PCPQVAQPIPQPQ-TEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQspTQLLHQNLP 376
Cdd:PRK14971 409 AQPSAPQSATQPAgTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQEK--AEQATGNIK 486
|
90
....*....|....
gi 2462613545 377 PVQAHPSAQSLSQP 390
Cdd:PRK14971 487 EAPTGTQKEIFTEE 500
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
303-393 |
8.29e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 40.35 E-value: 8.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 303 AQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPtqllhqnlPPVQAHP 382
Cdd:PRK07764 429 PQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAA--------PAAPAAP 500
|
90
....*....|.
gi 2462613545 383 SAQSLSQPLSA 393
Cdd:PRK07764 501 AAPAGADDAAT 511
|
|
| PRK10819 |
PRK10819 |
transport protein TonB; Provisional |
297-392 |
8.68e-03 |
|
transport protein TonB; Provisional
Pssm-ID: 236768 [Multi-domain] Cd Length: 246 Bit Score: 39.28 E-value: 8.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 297 DPCPQVAQPIPQPQTEPQlraPSPDPdlvqrTEAPPQPPPLSTQPPQGPPEAQLQPAP--------------QPQVQRPP 362
Cdd:PRK10819 58 LEPPQAVQPPPEPVVEPE---PEPEP-----IPEPPKEAPVVIPKPEPKPKPKPKPKPkpvkkveeqpkrevKPVEPRPA 129
|
90 100 110
....*....|....*....|....*....|....*
gi 2462613545 363 RP---QSPTQLLHQNLPPVQAHP--SAQSLSQPLS 392
Cdd:PRK10819 130 SPfenTAPARPTSSTATAAASKPvtSVSSGPRALS 164
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
290-451 |
9.12e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 40.44 E-value: 9.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 290 FEPVVLKDP--CPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSP 367
Cdd:PHA03378 643 FNVLVFPTPhqPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATG 722
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613545 368 TQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPlhsfTPTL 447
Cdd:PHA03378 723 RARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAP----TPQP 798
|
....
gi 2462613545 448 QPPA 451
Cdd:PHA03378 799 PPQA 802
|
|
| PRK11633 |
PRK11633 |
cell division protein DedD; Provisional |
291-357 |
9.35e-03 |
|
cell division protein DedD; Provisional
Pssm-ID: 236940 [Multi-domain] Cd Length: 226 Bit Score: 39.22 E-value: 9.35e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613545 291 EPVVLKDPCPQVAQPIPQPQTEPQlrapsPDPDLVQRTEAPPQPpplstqPPQGPPEAQLQPAPQPQ 357
Cdd:PRK11633 93 PNTPVEPEPAPVEPPKPKPVEKPK-----PKPKPQQKVEAPPAP------KPEPKPVVEEKAAPTGK 148
|
|
| |
