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Conserved domains on  [gi|2462627836|ref|XP_054182251|]
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histone deacetylase 6 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HDAC6-dom1 cd11682
Histone deacetylase 6, domain 1; Histone deacetylases 6 are class IIb Zn-dependent enzymes ...
 145-481 0e+00

Histone deacetylase 6, domain 1; Histone deacetylases 6 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin (substrate) and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).


:

Pssm-ID: 212545 [Multi-domain]  Cd Length: 337  Bit Score: 665.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 145 CLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHP 224
Cdd:cd11682     1 CLWDESFPECPERLHAIREKLIQEGLLERCVSVQAREASEEELLLVHSPEYVALMKSTQYMTEEELRTLADTYDSVYLHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 225 NSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQ 304
Cdd:cd11682    81 NSYSCACLAVGSVLQLVDKVLGGEIRNGLAIVRPPGHHAQHDKMDGYCMFNNVAIAARYAQQKHGVQRVLIVDWDVHHGQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 305 GTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQL 384
Cdd:cd11682   161 GTQFIFEQDPSVLYFSIHRYEQGRFWPHLKESDSSAVGFGRGEGYNINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 385 VLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCR 464
Cdd:cd11682   241 VLVAAGFDAVIGDPKGEMAATPACFAHLTHLLMGLAGGKLILSLEGGYNLRSLAEGVCASLKALLGDPCPMLESPGAPCR 320

                         330
                  ....*....|....*..
gi 2462627836 465 SAQASVSCALEALEPFW 481
Cdd:cd11682   321 SALASVSCTISALEPFW 337
Arginase_HDAC super family cl17011
Arginase-like and histone-like hydrolases; Arginase-like/histone-like hydrolase superfamily ...
 531-711 2.92e-113

Arginase-like and histone-like hydrolases; Arginase-like/histone-like hydrolase superfamily includes metal-dependent enzymes that belong to Arginase-like amidino hydrolase family and histone/histone-like deacetylase class I, II, IV family, respectively. These enzymes catalyze hydrolysis of amide bond. Arginases are known to be involved in control of cellular levels of arginine and ornithine, in histidine and arginine degradation and in clavulanic acid biosynthesis. Deacetylases play a role in signal transduction through histone and/or other protein modification and can repress/activate transcription of a number of different genes. They participate in different cellular processes including cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and post-translational control of the acetyl coenzyme A synthetase. Mammalian histone deacetyases are known to be involved in progression of different tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs.


The actual alignment was detected with superfamily member cd10003:

Pssm-ID: 450134 [Multi-domain]  Cd Length: 350  Bit Score: 346.63  E-value: 2.92e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 531 YDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESS 610
Cdd:cd10003     1 YDQRMMNHHNLWDPGHPECPQRISRIYERHNDLGLLERCLRLPSRLATEDELLLCHSEEHLDEMKSLEKMKPRELNRLGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 611 NFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGhALRIL 690
Cdd:cd10003    81 EYDSIYIHPDSYQCALLAAGCVLQVVEAVLTGESRNGVAIVRPPGHHAEQDTACGFCFFNNVAIAARYAQKKYG-LKRIL 159

                         170       180
                  ....*....|....*....|.
gi 2462627836 691 IVDWDVHHGNGTQHMFEDDPS 711
Cdd:cd10003   160 IVDWDVHHGNGTQHMFESDPS 180
 
Name Accession Description Interval E-value
HDAC6-dom1 cd11682
Histone deacetylase 6, domain 1; Histone deacetylases 6 are class IIb Zn-dependent enzymes ...
 145-481 0e+00

Histone deacetylase 6, domain 1; Histone deacetylases 6 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin (substrate) and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).


Pssm-ID: 212545 [Multi-domain]  Cd Length: 337  Bit Score: 665.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 145 CLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHP 224
Cdd:cd11682     1 CLWDESFPECPERLHAIREKLIQEGLLERCVSVQAREASEEELLLVHSPEYVALMKSTQYMTEEELRTLADTYDSVYLHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 225 NSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQ 304
Cdd:cd11682    81 NSYSCACLAVGSVLQLVDKVLGGEIRNGLAIVRPPGHHAQHDKMDGYCMFNNVAIAARYAQQKHGVQRVLIVDWDVHHGQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 305 GTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQL 384
Cdd:cd11682   161 GTQFIFEQDPSVLYFSIHRYEQGRFWPHLKESDSSAVGFGRGEGYNINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 385 VLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCR 464
Cdd:cd11682   241 VLVAAGFDAVIGDPKGEMAATPACFAHLTHLLMGLAGGKLILSLEGGYNLRSLAEGVCASLKALLGDPCPMLESPGAPCR 320

                         330
                  ....*....|....*..
gi 2462627836 465 SAQASVSCALEALEPFW 481
Cdd:cd11682   321 SALASVSCTISALEPFW 337
Hist_deacetyl pfam00850
Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. ...
 152-448 3.21e-115

Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyze the removal of the acetyl group. Histone deacetylases are related to other proteins.


Pssm-ID: 425906 [Multi-domain]  Cd Length: 298  Bit Score: 349.61  E-value: 3.21e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 152 PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYID-LMETTQYMNEGELRVLADTYDSVYLHPNSYSCA 230
Cdd:pfam00850   2 PENPERLKAILEALREAGLLPDLEIIAPRPATEEELLLVHSPEYLEfLEEAAPEGGALLLLSYLSGDDDTPVSPGSYEAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 231 CLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTF 310
Cdd:pfam00850  82 LLAAGGTLAAADAVLSGEARNAFALVRPPGHHAERDRASGFCIFNNVAIAAKYLREKYGLKRVAIVDFDVHHGNGTQEIF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 311 DQDPSVLYFSIHRYEqGRFWPHLkaSNWSTTGFGQGQGYTINVPWNqVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAG 390
Cdd:pfam00850 162 YDDPSVLTLSIHQYP-GGFYPGT--GFADETGEGKGKGYTLNVPLP-PGTGDAEYLAAFEEILLPALEEFQPDLILVSAG 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462627836 391 FDALQGDPKGEMAATPAGFAQLTHLLMGLA---GGKLILSLEGGYNLRALAEGVSASLHTL 448
Cdd:pfam00850 238 FDAHAGDPLGGLNLTTEGFAEITRILLELAdplCIRVVSVLEGGYNLDALARSATAVLAAL 298
HDAC6-dom2 cd10003
Histone deacetylase 6, domain 2; Histone deacetylase 6 is a class IIb Zn-dependent enzyme that ...
 531-711 2.92e-113

Histone deacetylase 6, domain 2; Histone deacetylase 6 is a class IIb Zn-dependent enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).


Pssm-ID: 212527 [Multi-domain]  Cd Length: 350  Bit Score: 346.63  E-value: 2.92e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 531 YDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESS 610
Cdd:cd10003     1 YDQRMMNHHNLWDPGHPECPQRISRIYERHNDLGLLERCLRLPSRLATEDELLLCHSEEHLDEMKSLEKMKPRELNRLGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 611 NFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGhALRIL 690
Cdd:cd10003    81 EYDSIYIHPDSYQCALLAAGCVLQVVEAVLTGESRNGVAIVRPPGHHAEQDTACGFCFFNNVAIAARYAQKKYG-LKRIL 159

                         170       180
                  ....*....|....*....|.
gi 2462627836 691 IVDWDVHHGNGTQHMFEDDPS 711
Cdd:cd10003   160 IVDWDVHHGNGTQHMFESDPS 180
AcuC COG0123
Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites ...
 152-450 1.80e-100

Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439893 [Multi-domain]  Cd Length: 308  Bit Score: 311.66  E-value: 1.80e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 152 PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYmNEGELRVLADTYdsvyLHPNSYSCAC 231
Cdd:COG0123    19 PEPPERLRAILDALEASGLLDDLELVEPPPATEEDLLRVHTPDYVDALRAASL-DGGYGQLDPDTP----VSPGTWEAAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 232 LASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAqQKHRIRRVLIVDWDVHHGQGTQFTFD 311
Cdd:COG0123    94 LAAGGALAAADAVLEGEARNAFALVRPPGHHAERDRAMGFCLFNNAAIAARYL-LAKGLERVAIVDFDVHHGNGTQDIFY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 312 QDPSVLYFSIHryeQGRFWPHLKASnwSTTGFGQGQGYTINVPwnqV--GMRDADYIAAFLHVLLPVALEFQPQLVLVAA 389
Cdd:COG0123   173 DDPDVLTISIH---QDPLYPGTGAA--DETGEGAGEGSNLNVP---LppGTGDAEYLAALEEALLPALEAFKPDLIVVSA 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462627836 390 GFDALQGDPKGEMAATPAGFAQLTHLLMGLA---GGKLILSLEGGYNLRALAEGVSASLHTLLG 450
Cdd:COG0123   245 GFDAHADDPLGRLNLTTEGYAWRTRRVLELAdhcGGPVVSVLEGGYNLDALARSVAAHLETLLG 308
Hist_deacetyl pfam00850
Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. ...
 546-711 1.04e-67

Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyze the removal of the acetyl group. Histone deacetylases are related to other proteins.


Pssm-ID: 425906 [Multi-domain]  Cd Length: 298  Bit Score: 225.19  E-value: 1.04e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 546 HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLR-ATEKMKTRELHRESSNFDSIYICPSTFAC 624
Cdd:pfam00850   1 HPENPERLKAILEALREAGLLPDLEIIAPRPATEEELLLVHSPEYLEFLEeAAPEGGALLLLSYLSGDDDTPVSPGSYEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 625 AQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHAlRILIVDWDVHHGNGTQH 704
Cdd:pfam00850  81 ALLAAGGTLAAADAVLSGEARNAFALVRPPGHHAERDRASGFCIFNNVAIAAKYLREKYGLK-RVAIVDFDVHHGNGTQE 159


                  ....*..
gi 2462627836 705 MFEDDPS 711
Cdd:pfam00850 160 IFYDDPS 166
AcuC COG0123
Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites ...
 527-711 6.89e-57

Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439893 [Multi-domain]  Cd Length: 308  Bit Score: 196.48  E-value: 6.89e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 527 TGLVYDQNMMNHcNLWDsHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVghlratEKMKTRELH 606
Cdd:COG0123     1 TALIYHPDYLLH-DLGP-GHPEPPERLRAILDALEASGLLDDLELVEPPPATEEDLLRVHTPDYV------DALRAASLD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 607 RESSNFDSI-YICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQtiSGH 685
Cdd:COG0123    73 GGYGQLDPDtPVSPGTWEAALLAAGGALAAADAVLEGEARNAFALVRPPGHHAERDRAMGFCLFNNAAIAARYLL--AKG 150

                         170       180
                  ....*....|....*....|....*.
gi 2462627836 686 ALRILIVDWDVHHGNGTQHMFEDDPS 711
Cdd:COG0123   151 LERVAIVDFDVHHGNGTQDIFYDDPD 176
PTZ00063 PTZ00063
histone deacetylase; Provisional
 261-455 4.64e-16

histone deacetylase; Provisional


Pssm-ID: 240251  Cd Length: 436  Bit Score: 81.40  E-value: 4.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 261 HHAQHSLMDGYCMFNHVAVAARYAQQKHRirRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYeqGRFWPhlKASNWST 340
Cdd:PTZ00063  137 HHAKRSEASGFCYINDIVLGILELLKYHA--RVMYIDIDVHHGDGVEEAFYVTHRVMTVSFHKF--GDFFP--GTGDVTD 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 341 TGFGQGQGYTINVPWNQvGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLA 420
Cdd:PTZ00063  211 IGVAQGKYYSVNVPLND-GIDDDSFVDLFKPVISKCVEVYRPGAIVLQCGADSLTGDRLGRFNLTIKGHAACVEFVRSLN 289

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2462627836 421 GGKLILSlEGGYNLRALAE------GVSASLHTLLGDPCPM 455
Cdd:PTZ00063  290 IPLLVLG-GGGYTIRNVARcwayetGVILNKHDEMSDQISL 329
PTZ00063 PTZ00063
histone deacetylase; Provisional
 546-706 2.38e-07

histone deacetylase; Provisional


Pssm-ID: 240251  Cd Length: 436  Bit Score: 53.66  E-value: 2.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 546 HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRE----LHR----ESSN---FDS 614
Cdd:PTZ00063   23 HPMKPQRIRMAHALILSYDLYKHMEIYRPHKSVEPELVLFHDEEYVDFLSSISPENYRDftyqLKRfnvgEATDcpvFDG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 615 IYicpsTF--ACAQLATGAACRL------VEAVLSGEVlngaavvrppgHHAEQDAACGFCFFNSVAVAArhAQTISGHA 686
Cdd:PTZ00063  103 LF----EFqqSCAGASIDGAYKLnnhqadICVNWSGGL-----------HHAKRSEASGFCYINDIVLGI--LELLKYHA 165

                         170       180
                  ....*....|....*....|
gi 2462627836 687 lRILIVDWDVHHGNGTQHMF 706
Cdd:PTZ00063  166 -RVMYIDIDVHHGDGVEEAF 184
 
Name Accession Description Interval E-value
HDAC6-dom1 cd11682
Histone deacetylase 6, domain 1; Histone deacetylases 6 are class IIb Zn-dependent enzymes ...
 145-481 0e+00

Histone deacetylase 6, domain 1; Histone deacetylases 6 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin (substrate) and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).


Pssm-ID: 212545 [Multi-domain]  Cd Length: 337  Bit Score: 665.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 145 CLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHP 224
Cdd:cd11682     1 CLWDESFPECPERLHAIREKLIQEGLLERCVSVQAREASEEELLLVHSPEYVALMKSTQYMTEEELRTLADTYDSVYLHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 225 NSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQ 304
Cdd:cd11682    81 NSYSCACLAVGSVLQLVDKVLGGEIRNGLAIVRPPGHHAQHDKMDGYCMFNNVAIAARYAQQKHGVQRVLIVDWDVHHGQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 305 GTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQL 384
Cdd:cd11682   161 GTQFIFEQDPSVLYFSIHRYEQGRFWPHLKESDSSAVGFGRGEGYNINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 385 VLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCR 464
Cdd:cd11682   241 VLVAAGFDAVIGDPKGEMAATPACFAHLTHLLMGLAGGKLILSLEGGYNLRSLAEGVCASLKALLGDPCPMLESPGAPCR 320

                         330
                  ....*....|....*..
gi 2462627836 465 SAQASVSCALEALEPFW 481
Cdd:cd11682   321 SALASVSCTISALEPFW 337
HDAC10_HDAC6-dom1 cd10002
Histone deacetylase 6, domain 1 and histone deacetylase 10; Histone deacetylases 6 and 10 are ...
 145-481 0e+00

Histone deacetylase 6, domain 1 and histone deacetylase 10; Histone deacetylases 6 and 10 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. HDAC10 has an N-terminal deacetylase domain and a C-terminal pseudo-repeat that shares significant similarity with its catalytic domain. It is located in the nucleus and cytoplasm, and is involved in regulation of melanogenesis. It transcriptionally down-regulates thioredoxin-interacting protein (TXNIP), leading to altered reactive oxygen species (ROS) signaling in human gastric cancer cells. Known interaction partners of HDAC6 are alpha tubulin (substrate) and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD) while interaction partners of HDAC10 are Pax3, KAP1, hsc70 and HDAC3 proteins.


Pssm-ID: 212526 [Multi-domain]  Cd Length: 336  Bit Score: 576.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 145 CLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHP 224
Cdd:cd10002     1 CNWDSNHIECPERLEAILERLTQDGLLERCVKIPAREAEEDEILLVHSQEYIDLVKSTETMEKEELESLCSGYDSVYLCP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 225 NSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQ 304
Cdd:cd10002    81 STYEAARLAAGSTIELVKAVMAGKIQNGFALIRPPGHHAMRNEANGYCIFNNVAIAAKYAIEKLGLKRILIVDWDVHHGQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 305 GTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQL 384
Cdd:cd10002   161 GTQQGFYEDPRVLYFSIHRYEHGRFWPHLFESDYDYIGVGHGYGFNVNVPLNQTGLGDADYLAIFHHILLPLALEFQPEL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 385 VLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLEsPGAPCR 464
Cdd:cd10002   241 VLVSAGFDASIGDPEGEMAVTPAGYAHLTRLLMGLAGGKLLLVLEGGYLLESLAESVSMTLRGLLGDPLPPLA-PPIPIR 319

                         330
                  ....*....|....*..
gi 2462627836 465 SAQASVSCALEALEPFW 481
Cdd:cd10002   320 SVLETILNAIAHLSPRW 336
HDAC6-dom2 cd10003
Histone deacetylase 6, domain 2; Histone deacetylase 6 is a class IIb Zn-dependent enzyme that ...
 137-484 6.67e-166

Histone deacetylase 6, domain 2; Histone deacetylase 6 is a class IIb Zn-dependent enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).


Pssm-ID: 212527 [Multi-domain]  Cd Length: 350  Bit Score: 481.84  E-value: 6.67e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 137 DEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADT 216
Cdd:cd10003     2 DQRMMNHHNLWDPGHPECPQRISRIYERHNDLGLLERCLRLPSRLATEDELLLCHSEEHLDEMKSLEKMKPRELNRLGKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 217 YDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIV 296
Cdd:cd10003    82 YDSIYIHPDSYQCALLAAGCVLQVVEAVLTGESRNGVAIVRPPGHHAEQDTACGFCFFNNVAIAARYAQKKYGLKRILIV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 297 DWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPV 376
Cdd:cd10003   162 DWDVHHGNGTQHMFESDPSVLYISLHRYDNGSFFPNSPEGNYDVVGKGKGEGFNVNIPWNKGGMGDAEYIAAFQQVVLPI 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 377 ALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPML 456
Cdd:cd10003   242 AYEFNPELVLVSAGFDAARGDPLGGCKVTPEGYAHMTHMLMSLAGGRVIVILEGGYNLTSISESMSMCTKTLLGDPPPVL 321

                         330       340
                  ....*....|....*....|....*...
gi 2462627836 457 ESPGAPCRSAQASVSCALEALEPFWEVL 484
Cdd:cd10003   322 DLPRPPCSSALKSINNVLQVHQKYWKSL 349
HDAC10 cd11683
Histone deacetylase 10; Histone deacetylases 10 are class IIb Zn-dependent enzymes that ...
 147-481 4.16e-152

Histone deacetylase 10; Histone deacetylases 10 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC10 has an N-terminal deacetylase domain and a C-terminal pseudo-repeat that shares significant similarity with its catalytic domain. It is located in the nucleus and cytoplasm, and is involved in regulation of melanogenesis. It transcriptionally down-regulates thioredoxin-interacting protein (TXNIP), leading to altered reactive oxygen species (ROS) signaling in human gastric cancer cells. Known interaction partners of HDAC10 are Pax3, KAP1, hsc70 and HDAC3 proteins.


Pssm-ID: 212546 [Multi-domain]  Cd Length: 337  Bit Score: 446.23  E-value: 4.16e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 147 WDDSF--PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHP 224
Cdd:cd11683     1 WDDPEceIEVPERLTASYERLRQYGLVQRCLRLPAREASEEEILLVHSPEYLSLVRETQVMNKEELMAISGKYDAVYFHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 225 NSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQ 304
Cdd:cd11683    81 NTFHCARLAAGATLQLVDAVLTGEVQNGMALVRPPGHHSQRNAANGFCVFNNVAIAAEYAKKKYGLHRILIVDWDVHHGQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 305 GTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQL 384
Cdd:cd11683   161 GIQYIFEEDPSVLYFSWHRYEHQRFWPFLRESDYDAVGRGKGLGFNINLPWNKVGMGNADYLAAFFHVLLPLAFEFDPEL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 385 VLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCR 464
Cdd:cd11683   241 VLVSAGFDSAIGDPEGQMCATPECFAHLTHLLMVLAGGKLCAVLEGGYHLESLAESVCMTVQTLLGDPLPRLSGEMTPCQ 320

                         330
                  ....*....|....*..
gi 2462627836 465 SAQASVSCALEALEPFW 481
Cdd:cd11683   321 SALESIQNVRAAQAPYW 337
HDAC_classII cd09992
Histone deacetylases and histone-like deacetylases, classII; Class II histone deacetylases are ...
 152-449 3.32e-136

Histone deacetylases and histone-like deacetylases, classII; Class II histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. This group includes animal HDAC4,5,6,7,8,9,10, fungal HOS3 and HDA1, plant HDA5 and HDA15 as well as other eukaryotes, archaeal and bacterial histone-like deacetylases. Eukaryotic deacetylases mostly use histones (H2, H3, H4) as substrates for deacetylation; however, non-histone substrates are known (for example, tubulin). Substrates for prokaryotic histone-like deacetylases are not known. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Interaction partners of class II deacetylases include 14-3-3 proteins, MEF2 family of transcriptional factors, CtBP, calmodulin (CaM), SMRT, N-CoR, BCL6, HP1alpha and SUMO. Histone deacetylases play a role in the regulation of cell cycle, cell differentiation and survival. Class II mammalian HDACs are differentially inhibited by structurally diverse compounds with known antitumor activities, thus presenting them as potential drug targets for human diseases resulting from aberrant acetylation.


Pssm-ID: 212518 [Multi-domain]  Cd Length: 291  Bit Score: 403.42  E-value: 3.32e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 152 PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELrvladtYDSVYLHPNSYSCAC 231
Cdd:cd09992     2 PERPERLLAILEALEEEGLLDRLVFVEPRPATEEELLRVHTPEYIERVEETCEAGGGYL------DPDTYVSPGSYEAAL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 232 LASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFD 311
Cdd:cd09992    76 LAAGAALAAVDAVLSGEAENAFALVRPPGHHAEPDRAMGFCLFNNVAIAARYAQKRYGLKRVLIVDWDVHHGNGTQDIFY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 312 QDPSVLYFSIHRYEqgrFWPHLKASNWstTGFGQGQGYTINVPWNQvGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGF 391
Cdd:cd09992   156 DDPSVLYFSIHQYP---FYPGTGAAEE--TGGGAGEGFTINVPLPP-GSGDAEYLAAFEEVLLPIAREFQPDLVLVSAGF 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462627836 392 DALQGDPKGEMAATPAGFAQLTHLLMGLA----GGKLILSLEGGYNLRALAEGVSASLHTLL 449
Cdd:cd09992   230 DAHRGDPLGGMNLTPEGYARLTRLLKELAdehcGGRLVFVLEGGYNLEALAESVLAVLEALL 291
HDAC_Clr3 cd11600
Class II Histone deacetylase Clr3 and similar proteins; Clr3 is a class II Histone ...
 149-456 1.36e-123

Class II Histone deacetylase Clr3 and similar proteins; Clr3 is a class II Histone deacetylase Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Clr3 is the homolog of the class-II HDAC HdaI in S. cerevisiae, and is essential for silencing in heterochromatin regions, such as centromeric regions, ribosomal DNA, the mating-type region and telomeric loci. Clr3 has also been implicated in the regulation of stress-related genes; the histone acetyltransferase, Gcn5, in S. cerevisiae, preferentially acetylates global histone H3K14 while Clr3 preferentially deacetylates H3K14ac, and therefore, interplay between Gcn5 and Clr3 is crucial for the regulation of many stress-response genes.


Pssm-ID: 212542 [Multi-domain]  Cd Length: 313  Bit Score: 371.68  E-value: 1.36e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 149 DSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAD--TYDSVYLHPNS 226
Cdd:cd11600     1 DPHPEDPSRISRIFEKLKEAGLINRMLRIPIREATKEEILLVHSEEHWDRVEATEKMSDEQLKDRTEifERDSLYVNNDT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 227 YSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKH--RIRRVLIVDWDVHHGQ 304
Cdd:cd11600    81 AFCARLSCGGAIEACRAVAEGRVKNAFAVVRPPGHHAEPDESMGFCFFNNVAVAAKWLQTEYpdKIKKILILDWDIHHGN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 305 GTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQL 384
Cdd:cd11600   161 GTQRAFYDDPNVLYISLHRFENGGFYPGTPYGDYESVGEGAGLGFNVNIPWPQGGMGDADYIYAFQRIVMPIAYEFDPDL 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462627836 385 VLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPML 456
Cdd:cd11600   241 VIISAGFDAADGDELGQCHVTPAGYAHMTHMLMSLAGGKLVVALEGGYNLDAISDSALAVAKVLLGEAPPKL 312
Hist_deacetyl pfam00850
Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. ...
 152-448 3.21e-115

Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyze the removal of the acetyl group. Histone deacetylases are related to other proteins.


Pssm-ID: 425906 [Multi-domain]  Cd Length: 298  Bit Score: 349.61  E-value: 3.21e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 152 PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYID-LMETTQYMNEGELRVLADTYDSVYLHPNSYSCA 230
Cdd:pfam00850   2 PENPERLKAILEALREAGLLPDLEIIAPRPATEEELLLVHSPEYLEfLEEAAPEGGALLLLSYLSGDDDTPVSPGSYEAA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 231 CLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTF 310
Cdd:pfam00850  82 LLAAGGTLAAADAVLSGEARNAFALVRPPGHHAERDRASGFCIFNNVAIAAKYLREKYGLKRVAIVDFDVHHGNGTQEIF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 311 DQDPSVLYFSIHRYEqGRFWPHLkaSNWSTTGFGQGQGYTINVPWNqVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAG 390
Cdd:pfam00850 162 YDDPSVLTLSIHQYP-GGFYPGT--GFADETGEGKGKGYTLNVPLP-PGTGDAEYLAAFEEILLPALEEFQPDLILVSAG 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462627836 391 FDALQGDPKGEMAATPAGFAQLTHLLMGLA---GGKLILSLEGGYNLRALAEGVSASLHTL 448
Cdd:pfam00850 238 FDAHAGDPLGGLNLTTEGFAEITRILLELAdplCIRVVSVLEGGYNLDALARSATAVLAAL 298
HDAC6-dom2 cd10003
Histone deacetylase 6, domain 2; Histone deacetylase 6 is a class IIb Zn-dependent enzyme that ...
 531-711 2.92e-113

Histone deacetylase 6, domain 2; Histone deacetylase 6 is a class IIb Zn-dependent enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).


Pssm-ID: 212527 [Multi-domain]  Cd Length: 350  Bit Score: 346.63  E-value: 2.92e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 531 YDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESS 610
Cdd:cd10003     1 YDQRMMNHHNLWDPGHPECPQRISRIYERHNDLGLLERCLRLPSRLATEDELLLCHSEEHLDEMKSLEKMKPRELNRLGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 611 NFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGhALRIL 690
Cdd:cd10003    81 EYDSIYIHPDSYQCALLAAGCVLQVVEAVLTGESRNGVAIVRPPGHHAEQDTACGFCFFNNVAIAARYAQKKYG-LKRIL 159

                         170       180
                  ....*....|....*....|.
gi 2462627836 691 IVDWDVHHGNGTQHMFEDDPS 711
Cdd:cd10003   160 IVDWDVHHGNGTQHMFESDPS 180
HDAC_classIIa cd11681
Histone deacetylases, class IIa; Class IIa histone deacetylases are Zn-dependent enzymes that ...
 131-481 7.11e-103

Histone deacetylases, class IIa; Class IIa histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) to yield deacetylated histones. This subclass includes animal HDAC4, HDAC5, HDAC7, and HDCA9. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, they have N-terminal regulatory domain with two or three conserved serine residues, phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC9 is involved in regulation of gene expression and dendritic growth in developing cortical neurons. It also plays a role in hematopoiesis. HDAC7 is involved in regulation of myocyte migration and differentiation. HDAC5 is involved in integration of chronic drug (cocaine) addiction and depression with changes in chromatin structure and gene expression. HDAC4 participates in regulation of chondrocyte hypertrophy and skeletogenesis.


Pssm-ID: 212544 [Multi-domain]  Cd Length: 377  Bit Score: 320.45  E-value: 7.11e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 131 GTGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQ----- 203
Cdd:cd11681     2 TTGLAYDPLMLKHQCICGNNssHPEHGGRLQSIWSRLQETGLVNRCERLRGRKATLEELQLVHSEVHTLLYGTNPlsrlk 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 204 ---------------YMNEGELRVLADTYDSVyLHpnSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLM 268
Cdd:cd11681    82 ldptklaglpqksfvRLPCGGIGVDSDTVWNE-LH--TSNAARMAVGCVIDLAFKVATGELKNGFAVVRPPGHHAEPSQA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 269 DGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNwsTTGFGQGQG 348
Cdd:cd11681   159 MGFCFFNSVAIAAKQLQQKLKLRKILIVDWDVHHGNGTQQIFYEDPNVLYISLHRYDDGNFFPGTGAPT--EVGSGAGEG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 349 YTINVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPK--GEMAATPAGFAQLTHLLMGLAGGK 423
Cdd:cd11681   237 FNVNIAWSgglDPPMGDAEYLAAFRTVVMPIAREFSPDIVLVSAGFDAAEGHPPplGGYKVSPACFGYMTRQLMNLAGGK 316

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462627836 424 LILSLEGGYNLRALAEGVSASLHTLLGD---PCPMLESPGAPCRSAQASVSCALEALEPFW 481
Cdd:cd11681   317 VVLALEGGYDLTAICDASEACVRALLGDeldPLSEEELERRPNPNAVTSLEKVIAIQSPYW 377
AcuC COG0123
Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites ...
 152-450 1.80e-100

Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439893 [Multi-domain]  Cd Length: 308  Bit Score: 311.66  E-value: 1.80e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 152 PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYmNEGELRVLADTYdsvyLHPNSYSCAC 231
Cdd:COG0123    19 PEPPERLRAILDALEASGLLDDLELVEPPPATEEDLLRVHTPDYVDALRAASL-DGGYGQLDPDTP----VSPGTWEAAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 232 LASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAqQKHRIRRVLIVDWDVHHGQGTQFTFD 311
Cdd:COG0123    94 LAAGGALAAADAVLEGEARNAFALVRPPGHHAERDRAMGFCLFNNAAIAARYL-LAKGLERVAIVDFDVHHGNGTQDIFY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 312 QDPSVLYFSIHryeQGRFWPHLKASnwSTTGFGQGQGYTINVPwnqV--GMRDADYIAAFLHVLLPVALEFQPQLVLVAA 389
Cdd:COG0123   173 DDPDVLTISIH---QDPLYPGTGAA--DETGEGAGEGSNLNVP---LppGTGDAEYLAALEEALLPALEAFKPDLIVVSA 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462627836 390 GFDALQGDPKGEMAATPAGFAQLTHLLMGLA---GGKLILSLEGGYNLRALAEGVSASLHTLLG 450
Cdd:COG0123   245 GFDAHADDPLGRLNLTTEGYAWRTRRVLELAdhcGGPVVSVLEGGYNLDALARSVAAHLETLLG 308
HDAC4 cd10006
Histone deacetylase 4; Histone deacetylase 4 is a class IIa Zn-dependent enzyme that catalyzes ...
 132-493 7.14e-85

Histone deacetylase 4; Histone deacetylase 4 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC4 participates in regulation of chondrocyte hypertrophy and skeletogenesis. However, biological substrates for HDAC4 have not been identified; only low lysine deacetylation activity has been demonstrated and active site mutant has enhanced activity toward acetylated lysines. HDAC4 does not bind DNA directly, but through transcription factors MEF2C (myocyte enhancer factor-2C) and MEF2D. Other known interaction partners of the protein are 14-3-3 proteins, SMRT and N-CoR co-repressors, BCL6, HP1, SUMO-1 ubiquitin-like protein, and ANKRA2. It appears to interact in a multiprotein complex with RbAp48 and HDAC3. Furthermore, HDAC4 is required for TGFbeta1-induced myofibroblastic differentiation.


Pssm-ID: 212530 [Multi-domain]  Cd Length: 409  Bit Score: 274.61  E-value: 7.14e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 132 TGLVLDEQLNEFHCLW--DDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSlEYIDLMETTQYMNEGE 209
Cdd:cd10006     6 TGLVYDTLMLKHQCTCgnSNSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHS-EAHTLLYGTNPLNRQK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 210 L------RVLADTY------------DSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGY 271
Cdd:cd10006    85 LdskkllGSLASVFvrlpcggvgvdsDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 272 CMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNwsTTGFGQGQGYTI 351
Cdd:cd10006   165 CYFNSVAIAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYSDPNVLYMSLHRYDDGNFFPGSGAPD--EVGTGPGVGFNV 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 352 NVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPK--GEMAATPAGFAQLTHLLMGLAGGKLIL 426
Cdd:cd10006   243 NMAFTgglDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTplGGYNLSAKCFGYLTKQLMGLAGGRIVL 322

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 427 SLEGGYNLRALAEGVSASLHTLLG---DPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVER 493
Cdd:cd10006   323 ALEGGHDLTAICDASEACVSALLGnelDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGY 392
HDAC_classII_2 cd11599
Histone deacetylases and histone-like deacetylases, classII; This subfamily includes ...
 152-449 1.76e-84

Histone deacetylases and histone-like deacetylases, classII; This subfamily includes eukaryotic as well as bacterial Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. In D. discoideum, where four homologs (HdaA, HdaB, HdaC, HdaD) have been identified, HDAC activity is important for regulating the timing of gene expression during development. Also, inhibition of HDAC activity by trichostatin A is shown to cause hyperacetylation of the histone and a delay in cell aggregation and differentiation.


Pssm-ID: 212541 [Multi-domain]  Cd Length: 288  Bit Score: 269.38  E-value: 1.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 152 PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQyMNEGELRVLADTYDSvylhPNSYSCAC 231
Cdd:cd11599     2 PESPERLEAILDALIASGLDRLLRQLEAPPATREQLLRVHDAAYVDRLEAAA-PEEGLVQLDPDTAMS----PGSLEAAL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 232 LASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFD 311
Cdd:cd11599    77 RAAGAVVAAVDAVMAGEARNAFCAVRPPGHHAERDKAMGFCLFNNVAIAAAHALAHHGLERVAIVDFDVHHGNGTEDIFR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 312 QDPSVLYFSIHRYeqgRFWPHlkasnwstTGFGQ--GQGYTINVPWNQvGMRDADYIAAFLHVLLPVALEFQPQLVLVAA 389
Cdd:cd11599   157 DDPRVLFCSSHQH---PLYPG--------TGAPDetGHGNIVNVPLPA-GTGGAEFREAVEDRWLPALDAFKPDLILISA 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462627836 390 GFDALQGDPKGEMAATPAGFAQLTHLLMGLA----GGKLILSLEGGYNLRALAEGVSASLHTLL 449
Cdd:cd11599   225 GFDAHRDDPLAQLNLTEEDYAWITEQLMDVAdrycDGRIVSVLEGGYDLSALARSVAAHVRALM 288
HDAC7 cd10008
Histone deacetylase 7; Histone deacetylase 7 is a class IIa Zn-dependent enzyme that catalyzes ...
 132-481 2.36e-83

Histone deacetylase 7; Histone deacetylase 7 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC7 is involved in regulation of myocyte migration and differentiation. Known interaction partners of class IIa HDAC7 are myocyte enhancer factors - MEF2A, -2C, and -2D, 14-3-3 proteins, SMRT and N-CoR co-repressors, HDAC3, ETA (endothelin receptor). This enzyme is also involved in the development of the immune system as well as brain and heart development. Multiple alternatively spliced transcript variants encoding several isoforms have been found for this gene.


Pssm-ID: 212532 [Multi-domain]  Cd Length: 378  Bit Score: 269.57  E-value: 2.36e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 132 TGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQY----M 205
Cdd:cd10008     3 TGLVYDSVMLKHQCSCGDNsnHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLsrlkL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 206 NEGELR---------------VLADTyDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDG 270
Cdd:cd10008    83 DNGKLAgllaqrmfvmlpcggVGVDT-DTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 271 YCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNwsTTGFGQGQGYT 350
Cdd:cd10008   162 FCFFNSVAIACRQLQQQGKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVD--EVGAGSGEGFN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 351 INVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPK--GEMAATPAGFAQLTHLLMGLAGGKLI 425
Cdd:cd10008   240 VNVAWAgglDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAplGGYHVSAKCFGYMTQQLMNLAGGAVV 319

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462627836 426 LSLEGGYNLRALAEGVSASLHTLLG---DPCPMLESPGAPCRSAQASVSCALEALEPFW 481
Cdd:cd10008   320 LALEGGHDLTAICDASEACVAALLGnevDPLSEESWKQKPNLNAIRSLEAVIRVHSKYW 378
HDAC5 cd10007
Histone deacetylase 5; Histone deacetylase 5 is a class IIa Zn-dependent enzyme that catalyzes ...
 129-493 5.52e-83

Histone deacetylase 5; Histone deacetylase 5 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC5 is involved in integration of chronic drug (cocaine) addiction and depression with changes in chromatin structure and gene expression; cocaine regulates HDAC5 function to antagonize the rewarding impact of cocaine, possibly by blocking drug-stimulated gene expression that supports drug-induced behavioral change. It is also involved in regulation of angiogenesis and cell cycle as well as immune system development. HDAC5 and HDAC9 have been found to be significantly up-regulated in high-risk medulloblastoma compared with low-risk and may potentially be novel drug targets.


Pssm-ID: 212531 [Multi-domain]  Cd Length: 420  Bit Score: 269.93  E-value: 5.52e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 129 LAGTGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSlEYIDLMETTQYMN 206
Cdd:cd10007     2 LFTTGLVYDTFMLKHQCTCGNTnvHPEHAGRIQSVWSRLQETGLLGKCERVRGRKATLDEIQTVHS-EHHTLLYGTSPLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 207 EGELR--------------VL------ADTyDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHS 266
Cdd:cd10007    81 RQKLDskkllgplsqkmyaVLpcggigVDS-DTVWNEMHSSSAVRMAVGCLIELAFKVAAGELKNGFAVIRPPGHHAEES 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 267 LMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNwsTTGFGQG 346
Cdd:cd10007   160 TAMGFCFFNSVAIAAKLLQQKLNVGKILIVDWDIHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGSGAPD--EVGAGPG 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 347 QGYTINVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQG--DPKGEMAATPAGFAQLTHLLMGLAG 421
Cdd:cd10007   238 VGFNVNIAWTggvDPPIGDVEYLTAFRTVVMPIANEFSPDVVLVSAGFDAVEGhqSPLGGYSVTAKCFGHLTKQLMTLAG 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462627836 422 GKLILSLEGGYNLRALAEGVSASLHTLLGD---PCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVER 493
Cdd:cd10007   318 GRVVLALEGGHDLTAICDASEACVSALLGMeltPLDNTVLQQKPNDNAVATLERVIEIQSKHWSCLKRFAATLGF 392
HDAC_classII_1 cd09996
Histone deacetylases and histone-like deacetylases, classII; This subfamily includes bacterial ...
 132-477 2.21e-78

Histone deacetylases and histone-like deacetylases, classII; This subfamily includes bacterial as well as eukaryotic Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. Included in this family is a bacterial HDAC-like amidohydrolase (Bordetella/Alcaligenes species FB18817, denoted as FB188 HDAH) shown to be most similar in sequence and function to class II HDAC6 domain 3 or b (HDAC6b). FB188 HDAH is able to remove the acetyl moiety from acetylated histones, and can be inhibited by common HDAC inhibitors such as SAHA (suberoylanilide hydroxamic acid) as well as class II-specific but not class I specific inhibitors.


Pssm-ID: 212521 [Multi-domain]  Cd Length: 359  Bit Score: 255.56  E-value: 2.21e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 132 TGLVLDEqlnefHCLWDDS------------------FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSL 193
Cdd:cd09996     1 TGFVWDE-----RYLWHDTgtgalflpvggllvqpgrHPENPETKRRIKNLLEVSGLSDHLVLITPRPATDEELLRVHTP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 194 EYIDLMETTQYMNEGELRVLAdtydsvYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCM 273
Cdd:cd09996    76 EYIDRVKAASAAGGGEAGGGT------PFGPGSYEIALLAAGGAIAAVDAVLDGEVDNAYALVRPPGHHAEPDQGMGFCL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 274 FNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHryeQGRFWPHlkasNWST---TGFGQGQGYT 350
Cdd:cd09996   150 FNNVAIAARHALAVGGVKRVAVVDWDVHHGNGTQAIFYDDPDVLTISLH---QDRCFPP----DSGAveeRGEGAGEGYN 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 351 INVPW-NQVGmrDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLA----GGKLI 425
Cdd:cd09996   223 LNIPLpPGSG--DGAYLHAFERIVLPALRAFRPELIIVASGFDASAFDPLGRMMLTSDGFRALTRKLRDLAdelcGGRLV 300

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462627836 426 LSLEGGYNLRALAEGVSASLHTLLGDPC----PMLESPGA-PCRSAQASVSCALEAL 477
Cdd:cd09996   301 MVHEGGYSEAYVPFCGLAVLEELSGVRTgiadPLLYYPEAqGGQELQPHQRAAIDAA 357
HDAC_classII cd09992
Histone deacetylases and histone-like deacetylases, classII; Class II histone deacetylases are ...
 546-711 5.62e-75

Histone deacetylases and histone-like deacetylases, classII; Class II histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. This group includes animal HDAC4,5,6,7,8,9,10, fungal HOS3 and HDA1, plant HDA5 and HDA15 as well as other eukaryotes, archaeal and bacterial histone-like deacetylases. Eukaryotic deacetylases mostly use histones (H2, H3, H4) as substrates for deacetylation; however, non-histone substrates are known (for example, tubulin). Substrates for prokaryotic histone-like deacetylases are not known. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Interaction partners of class II deacetylases include 14-3-3 proteins, MEF2 family of transcriptional factors, CtBP, calmodulin (CaM), SMRT, N-CoR, BCL6, HP1alpha and SUMO. Histone deacetylases play a role in the regulation of cell cycle, cell differentiation and survival. Class II mammalian HDACs are differentially inhibited by structurally diverse compounds with known antitumor activities, thus presenting them as potential drug targets for human diseases resulting from aberrant acetylation.


Pssm-ID: 212518 [Multi-domain]  Cd Length: 291  Bit Score: 244.33  E-value: 5.62e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 546 HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHressnfDSIYICPSTFACA 625
Cdd:cd09992     1 HPERPERLLAILEALEEEGLLDRLVFVEPRPATEEELLRVHTPEYIERVEETCEAGGGYLD------PDTYVSPGSYEAA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 626 QLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHAlRILIVDWDVHHGNGTQHM 705
Cdd:cd09992    75 LLAAGAALAAVDAVLSGEAENAFALVRPPGHHAEPDRAMGFCLFNNVAIAARYAQKRYGLK-RVLIVDWDVHHGNGTQDI 153


                  ....*.
gi 2462627836 706 FEDDPS 711
Cdd:cd09992   154 FYDDPS 159
HDAC9 cd10009
Histone deacetylase 9; Histone deacetylase 9 is a class IIa Zn-dependent enzyme that catalyzes ...
 132-482 8.42e-73

Histone deacetylase 9; Histone deacetylase 9 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, they have N-terminal regulatory domain with two or three conserved serine residues, phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC9 is involved in regulation of gene expression and dendritic growth in developing cortical neurons. It also plays a role in hematopoiesis. Its deregulated expression may be associated with some human cancers. HDAC5 and HDAC9 have been found to be significantly up-regulated in high-risk medulloblastoma compared with low-risk and may potentially be novel drug targets.


Pssm-ID: 212533 [Multi-domain]  Cd Length: 379  Bit Score: 241.84  E-value: 8.42e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 132 TGLVLDEQLNEFHCLWDDS--FPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSlEYIDLMETTQYMNEGE 209
Cdd:cd10009     3 TGIAYDPLMLKHQCVCGNSttHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS-EHHSLLYGTNPLDGQK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 210 L---RVLADTY----------------DSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDG 270
Cdd:cd10009    82 LdprILLGDDSqkffsslpcgglgvdsDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 271 YCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNwsTTGFGQGQGYT 350
Cdd:cd10009   162 FCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPN--EVGTGLGEGYN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 351 INVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGD--PKGEMAATPAGFAQLTHLLMGLAGGKLI 425
Cdd:cd10009   240 INIAWTgglDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHtpPLGGYKVTAKCFGHLTKQLMTLADGRVV 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 426 LSLEGGYNLRALAEGVSASLHTLLG---DPCPMLESPGAPCRSAQASVSCALEALEPFWE 482
Cdd:cd10009   320 LALEGGHDLTAICDASEACVNALLGnelEPLAEDILHQSPNMNAVISLQKIIEIQSKYWK 379
HDAC10_HDAC6-dom1 cd10002
Histone deacetylase 6, domain 1 and histone deacetylase 10; Histone deacetylases 6 and 10 are ...
 540-711 1.01e-67

Histone deacetylase 6, domain 1 and histone deacetylase 10; Histone deacetylases 6 and 10 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. HDAC10 has an N-terminal deacetylase domain and a C-terminal pseudo-repeat that shares significant similarity with its catalytic domain. It is located in the nucleus and cytoplasm, and is involved in regulation of melanogenesis. It transcriptionally down-regulates thioredoxin-interacting protein (TXNIP), leading to altered reactive oxygen species (ROS) signaling in human gastric cancer cells. Known interaction partners of HDAC6 are alpha tubulin (substrate) and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD) while interaction partners of HDAC10 are Pax3, KAP1, hsc70 and HDAC3 proteins.


Pssm-ID: 212526 [Multi-domain]  Cd Length: 336  Bit Score: 226.42  E-value: 1.01e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 540 NLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICP 619
Cdd:cd10002     1 CNWDSNHIECPERLEAILERLTQDGLLERCVKIPAREAEEDEILLVHSQEYIDLVKSTETMEKEELESLCSGYDSVYLCP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 620 STFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTiSGHALRILIVDWDVHHG 699
Cdd:cd10002    81 STYEAARLAAGSTIELVKAVMAGKIQNGFALIRPPGHHAMRNEANGYCIFNNVAIAAKYAIE-KLGLKRILIVDWDVHHG 159

                         170
                  ....*....|..
gi 2462627836 700 NGTQHMFEDDPS 711
Cdd:cd10002   160 QGTQQGFYEDPR 171
Hist_deacetyl pfam00850
Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. ...
 546-711 1.04e-67

Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyze the removal of the acetyl group. Histone deacetylases are related to other proteins.


Pssm-ID: 425906 [Multi-domain]  Cd Length: 298  Bit Score: 225.19  E-value: 1.04e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 546 HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLR-ATEKMKTRELHRESSNFDSIYICPSTFAC 624
Cdd:pfam00850   1 HPENPERLKAILEALREAGLLPDLEIIAPRPATEEELLLVHSPEYLEFLEeAAPEGGALLLLSYLSGDDDTPVSPGSYEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 625 AQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHAlRILIVDWDVHHGNGTQH 704
Cdd:pfam00850  81 ALLAAGGTLAAADAVLSGEARNAFALVRPPGHHAERDRASGFCIFNNVAIAAKYLREKYGLK-RVAIVDFDVHHGNGTQE 159


                  ....*..
gi 2462627836 705 MFEDDPS 711
Cdd:pfam00850 160 IFYDDPS 166
HDAC_classII_APAH cd10001
Histone deacetylase class IIa; This subfamily includes bacterial acetylpolyamine ...
 152-449 1.21e-63

Histone deacetylase class IIa; This subfamily includes bacterial acetylpolyamine amidohydrolase (APAH) as well as other Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. Mycoplana ramosa APAH exhibits broad substrate specificity and catalyzes the deacetylation of polyamines such as putrescine, spermidine, and spermine by cleavage of a non-peptide amide bond.


Pssm-ID: 212525 [Multi-domain]  Cd Length: 298  Bit Score: 214.32  E-value: 1.21e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 152 PEGPERLHAIKEQLIQEGLLDRCVsfQARFAEkEELMLVHSLEYIDLMETtqymnegelrvlADTydSVYLHPNSYSCAC 231
Cdd:cd10001    26 PENPERAEAILDALKRAGLGEVLP--PRDFGL-EPILAVHDPDYVDFLET------------ADT--DTPISEGTWEAAL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 232 LASGSVLRLVDAVLGAEiRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHriRRVLIVDWDVHHGQGTQFTFD 311
Cdd:cd10001    89 AAADTALTAADLVLEGE-RAAYALCRPPGHHAGRDRAGGFCYFNNAAIAAQYLRDRA--GRVAILDVDVHHGNGTQEIFY 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 312 QDPSVLYFSIHRYEQGrFWPHlkasnwsTTGF------GQGQGYTINVPWnQVGMRDADYIAAFLHVLLPVAlEFQPQLV 385
Cdd:cd10001   166 ERPDVLYVSIHGDPRT-FYPF-------FLGFadetgeGEGEGYNLNLPL-PPGTGDDDYLAALDEALAAIA-AFGPDAL 235

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462627836 386 LVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILsLEGGYNLRALAEGVSASLHTLL 449
Cdd:cd10001   236 VVSLGFDTHEGDPLSDFKLTTEDYARIGRRIAALGLPTVFV-QEGGYNVDALGRNAVAFLAGFE 298
HDAC_Clr3 cd11600
Class II Histone deacetylase Clr3 and similar proteins; Clr3 is a class II Histone ...
 545-711 9.95e-61

Class II Histone deacetylase Clr3 and similar proteins; Clr3 is a class II Histone deacetylase Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Clr3 is the homolog of the class-II HDAC HdaI in S. cerevisiae, and is essential for silencing in heterochromatin regions, such as centromeric regions, ribosomal DNA, the mating-type region and telomeric loci. Clr3 has also been implicated in the regulation of stress-related genes; the histone acetyltransferase, Gcn5, in S. cerevisiae, preferentially acetylates global histone H3K14 while Clr3 preferentially deacetylates H3K14ac, and therefore, interplay between Gcn5 and Clr3 is crucial for the regulation of many stress-response genes.


Pssm-ID: 212542 [Multi-domain]  Cd Length: 313  Bit Score: 207.20  E-value: 9.95e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 545 HHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNF--DSIYICPSTF 622
Cdd:cd11600     2 PHPEDPSRISRIFEKLKEAGLINRMLRIPIREATKEEILLVHSEEHWDRVEATEKMSDEQLKDRTEIFerDSLYVNNDTA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 623 ACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTI-SGHALRILIVDWDVHHGNG 701
Cdd:cd11600    82 FCARLSCGGAIEACRAVAEGRVKNAFAVVRPPGHHAEPDESMGFCFFNNVAVAAKWLQTEyPDKIKKILILDWDIHHGNG 161

                         170
                  ....*....|
gi 2462627836 702 TQHMFEDDPS 711
Cdd:cd11600   162 TQRAFYDDPN 171
HDAC cd09301
Histone deacetylase (HDAC) classes I, II, IV and related proteins; The HDAC/HDAC-like family ...
 157-448 1.09e-60

Histone deacetylase (HDAC) classes I, II, IV and related proteins; The HDAC/HDAC-like family includes Zn-dependent histone deacetylase classes I, II and IV (class III HDACs, also called sirtuins, are NAD-dependent and structurally unrelated, and therefore not part of this family). Histone deacetylases catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98), as opposed to the acetylation reaction by some histone acetyltransferases (EC 2.3.1.48). Deacetylases of this family are involved in signal transduction through histone and other protein modification, and can repress/activate transcription of a number of different genes. They usually act via the formation of large multiprotein complexes. They are involved in various cellular processes, including cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and post-translational control of the acetyl coenzyme A synthetase. In mammals, they are known to be involved in progression of different tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs.


Pssm-ID: 212512 [Multi-domain]  Cd Length: 279  Bit Score: 205.75  E-value: 1.09e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 157 RLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGS 236
Cdd:cd09301     1 RIRDLIEALKELGLRPKIELIECREATEELLLKVHTEEYLNELKANFAVATITESKPVIFGPNFPVQRHYFRGARLSTGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 237 VLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHrIRRVLIVDWDVHHGQGTQFTFDQDPSV 316
Cdd:cd09301    81 VVEAAELVAKGELERAFAVVGAGGHHAGKSRAWGFCYFNDVVLAIKFLRERG-ISRILIIDTDAHHGDGTREAFYDDDRV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 317 LYFSIHRYeqgrfwphlkasNWSTTGFGQGQGYTINVPWNQvGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQG 396
Cdd:cd09301   160 LHMSFHNY------------DIYPFGRGKGKGYKINVPLED-GLGDEEYLDAVERVISKVLEEFEPEVVVLQFGHDTHEG 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462627836 397 DPKGEMAATPAGFAQLTHLLMGLA-GGKLILSLEGGYNLRALAEGVSASLHTL 448
Cdd:cd09301   227 DRLGGFNLSEKGFVKLAEIVKEFArGGPILMVLGGGYNPEAAARIWTAIIKEL 279
HDAC6-dom1 cd11682
Histone deacetylase 6, domain 1; Histone deacetylases 6 are class IIb Zn-dependent enzymes ...
 541-712 2.03e-58

Histone deacetylase 6, domain 1; Histone deacetylases 6 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin (substrate) and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).


Pssm-ID: 212545 [Multi-domain]  Cd Length: 337  Bit Score: 201.62  E-value: 2.03e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 541 LWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPS 620
Cdd:cd11682     2 LWDESFPECPERLHAIREKLIQEGLLERCVSVQAREASEEELLLVHSPEYVALMKSTQYMTEEELRTLADTYDSVYLHPN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 621 TFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGhALRILIVDWDVHHGN 700
Cdd:cd11682    82 SYSCACLAVGSVLQLVDKVLGGEIRNGLAIVRPPGHHAQHDKMDGYCMFNNVAIAARYAQQKHG-VQRVLIVDWDVHHGQ 160

                         170
                  ....*....|..
gi 2462627836 701 GTQHMFEDDPSL 712
Cdd:cd11682   161 GTQFIFEQDPSV 172
AcuC COG0123
Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites ...
 527-711 6.89e-57

Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439893 [Multi-domain]  Cd Length: 308  Bit Score: 196.48  E-value: 6.89e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 527 TGLVYDQNMMNHcNLWDsHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVghlratEKMKTRELH 606
Cdd:COG0123     1 TALIYHPDYLLH-DLGP-GHPEPPERLRAILDALEASGLLDDLELVEPPPATEEDLLRVHTPDYV------DALRAASLD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 607 RESSNFDSI-YICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQtiSGH 685
Cdd:COG0123    73 GGYGQLDPDtPVSPGTWEAALLAAGGALAAADAVLEGEARNAFALVRPPGHHAERDRAMGFCLFNNAAIAARYLL--AKG 150

                         170       180
                  ....*....|....*....|....*.
gi 2462627836 686 ALRILIVDWDVHHGNGTQHMFEDDPS 711
Cdd:COG0123   151 LERVAIVDFDVHHGNGTQDIFYDDPD 176
HDAC10 cd11683
Histone deacetylase 10; Histone deacetylases 10 are class IIb Zn-dependent enzymes that ...
 548-712 3.45e-54

Histone deacetylase 10; Histone deacetylases 10 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC10 has an N-terminal deacetylase domain and a C-terminal pseudo-repeat that shares significant similarity with its catalytic domain. It is located in the nucleus and cytoplasm, and is involved in regulation of melanogenesis. It transcriptionally down-regulates thioredoxin-interacting protein (TXNIP), leading to altered reactive oxygen species (ROS) signaling in human gastric cancer cells. Known interaction partners of HDAC10 are Pax3, KAP1, hsc70 and HDAC3 proteins.


Pssm-ID: 212546 [Multi-domain]  Cd Length: 337  Bit Score: 190.07  E-value: 3.45e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 548 EVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQL 627
Cdd:cd11683     9 EVPERLTASYERLRQYGLVQRCLRLPAREASEEEILLVHSPEYLSLVRETQVMNKEELMAISGKYDAVYFHPNTFHCARL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 628 ATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQtiSGHAL-RILIVDWDVHHGNGTQHMF 706
Cdd:cd11683    89 AAGATLQLVDAVLTGEVQNGMALVRPPGHHSQRNAANGFCVFNNVAIAAEYAK--KKYGLhRILIVDWDVHHGQGIQYIF 166


                  ....*.
gi 2462627836 707 EDDPSL 712
Cdd:cd11683   167 EEDPSV 172
HDAC_classII_1 cd09996
Histone deacetylases and histone-like deacetylases, classII; This subfamily includes bacterial ...
 527-713 8.17e-53

Histone deacetylases and histone-like deacetylases, classII; This subfamily includes bacterial as well as eukaryotic Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. Included in this family is a bacterial HDAC-like amidohydrolase (Bordetella/Alcaligenes species FB18817, denoted as FB188 HDAH) shown to be most similar in sequence and function to class II HDAC6 domain 3 or b (HDAC6b). FB188 HDAH is able to remove the acetyl moiety from acetylated histones, and can be inhibited by common HDAC inhibitors such as SAHA (suberoylanilide hydroxamic acid) as well as class II-specific but not class I specific inhibitors.


Pssm-ID: 212521 [Multi-domain]  Cd Length: 359  Bit Score: 187.00  E-value: 8.17e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 527 TGLVYDQNMMNH-------------CNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGH 593
Cdd:cd09996     1 TGFVWDERYLWHdtgtgalflpvggLLVQPGRHPENPETKRRIKNLLEVSGLSDHLVLITPRPATDEELLRVHTPEYIDR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 594 LRATEKMKTRELHRESsnfdsiYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVA 673
Cdd:cd09996    81 VKAASAAGGGEAGGGT------PFGPGSYEIALLAAGGAIAAVDAVLDGEVDNAYALVRPPGHHAEPDQGMGFCLFNNVA 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2462627836 674 VAARHAQTiSGHALRILIVDWDVHHGNGTQHMFEDDPS-LT 713
Cdd:cd09996   155 IAARHALA-VGGVKRVAVVDWDVHHGNGTQAIFYDDPDvLT 194
HDAC_classII_2 cd11599
Histone deacetylases and histone-like deacetylases, classII; This subfamily includes ...
 546-712 9.59e-53

Histone deacetylases and histone-like deacetylases, classII; This subfamily includes eukaryotic as well as bacterial Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. In D. discoideum, where four homologs (HdaA, HdaB, HdaC, HdaD) have been identified, HDAC activity is important for regulating the timing of gene expression during development. Also, inhibition of HDAC activity by trichostatin A is shown to cause hyperacetylation of the histone and a delay in cell aggregation and differentiation.


Pssm-ID: 212541 [Multi-domain]  Cd Length: 288  Bit Score: 184.25  E-value: 9.59e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 546 HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATekmktRELHRESSNFDSIYICPSTFACA 625
Cdd:cd11599     1 HPESPERLEAILDALIASGLDRLLRQLEAPPATREQLLRVHDAAYVDRLEAA-----APEEGLVQLDPDTAMSPGSLEAA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 626 QLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGhALRILIVDWDVHHGNGTQHM 705
Cdd:cd11599    76 LRAAGAVVAAVDAVMAGEARNAFCAVRPPGHHAERDKAMGFCLFNNVAIAAAHALAHHG-LERVAIVDFDVHHGNGTEDI 154


                  ....*..
gi 2462627836 706 FEDDPSL 712
Cdd:cd11599   155 FRDDPRV 161
HDAC_classIIa cd11681
Histone deacetylases, class IIa; Class IIa histone deacetylases are Zn-dependent enzymes that ...
 527-711 4.03e-52

Histone deacetylases, class IIa; Class IIa histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) to yield deacetylated histones. This subclass includes animal HDAC4, HDAC5, HDAC7, and HDCA9. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, they have N-terminal regulatory domain with two or three conserved serine residues, phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC9 is involved in regulation of gene expression and dendritic growth in developing cortical neurons. It also plays a role in hematopoiesis. HDAC7 is involved in regulation of myocyte migration and differentiation. HDAC5 is involved in integration of chronic drug (cocaine) addiction and depression with changes in chromatin structure and gene expression. HDAC4 participates in regulation of chondrocyte hypertrophy and skeletogenesis.


Pssm-ID: 212544 [Multi-domain]  Cd Length: 377  Bit Score: 185.63  E-value: 4.03e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 527 TGLVYDQNMMNH---CNLwDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYV----GHLRATEK 599
Cdd:cd11681     3 TGLAYDPLMLKHqciCGN-NSSHPEHGGRLQSIWSRLQETGLVNRCERLRGRKATLEELQLVHSEVHTllygTNPLSRLK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 600 MKTRELHRES-SNF------------DSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGF 666
Cdd:cd11681    82 LDPTKLAGLPqKSFvrlpcggigvdsDTVWNELHTSNAARMAVGCVIDLAFKVATGELKNGFAVVRPPGHHAEPSQAMGF 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2462627836 667 CFFNSVAVAARHAQTISGHAlRILIVDWDVHHGNGTQHMFEDDPS 711
Cdd:cd11681   162 CFFNSVAIAAKQLQQKLKLR-KILIVDWDVHHGNGTQQIFYEDPN 205
HDAC_AcuC_like cd09994
Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; AcuC (Acetoin ...
 146-448 3.06e-46

Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; AcuC (Acetoin utilization protein) is a class I deacetylase found only in bacteria and is involved in post-translational control of the acetyl-coenzyme A synthetase (AcsA). Deacetylase AcuC works in coordination with deacetylase SrtN (class III), possibly to maintain AcsA in active (deacetylated) form and let the cell grow under low concentration of acetate. B. subtilis AcuC is a member of operon acuABC; this operon is repressed by the presence of glucose and does not show induction by acetoin; acetoin is a bacterial fermentation product that can be converted to acetate via the butanediol cycle in absence of other carbon sources. Inactivation of AcuC leads to slower growth and lower cell yield under low-acetate conditions in Bacillus subtilis. In general, Class I histone deacetylases (HDACs) are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase.


Pssm-ID: 212520 [Multi-domain]  Cd Length: 313  Bit Score: 167.35  E-value: 3.06e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 146 LWDDSF---------PEGPERLHAIKEqLIQE-GLLDRCVSFQARFAEKEELMLVHSLEYIDLME--TTQYMNEGELRVL 213
Cdd:cd09994     3 IYSEEYlrysfgpnhPFNPPRLSLTKD-LLRAlGLLPPVDLVPPRPATEEELLLFHTPDYIEAVKeaSRGQEPEGRGRLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 214 ADTYDSVYlHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIrppG--HHAQHSLMDGYCMFNHVAVAARYAQqKHRIR 291
Cdd:cd09994    82 LGTEDNPV-FPGMHEAAALVVGGTLLAARLVLEGEARRAFNPA---GglHHAMRGRASGFCVYNDAAVAIERLR-DKGGL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 292 RVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHryEQGR-FWPHLKASNwsTTGFGQGQGYTINVPWNQvGMRDADYIAAFL 370
Cdd:cd09994   157 RVAYVDIDAHHGDGVQAAFYDDPRVLTISLH--ESGRyLFPGTGFVD--EIGEGEGYGYAVNIPLPP-GTGDDEFLRAFE 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 371 HVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLA----GGKLILSLEGGYNLRALAEGVSASLH 446
Cdd:cd09994   232 AVVPPLLRAFRPDVIVSQHGADAHAGDPLTHLNLSNRAYRAAVRRIRELAdeycGGRWLALGGGGYNPDVVARAWALLWA 311


                  ..
gi 2462627836 447 TL 448
Cdd:cd09994   312 VL 313
HDAC4 cd10006
Histone deacetylase 4; Histone deacetylase 4 is a class IIa Zn-dependent enzyme that catalyzes ...
 527-712 6.22e-42

Histone deacetylase 4; Histone deacetylase 4 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC4 participates in regulation of chondrocyte hypertrophy and skeletogenesis. However, biological substrates for HDAC4 have not been identified; only low lysine deacetylation activity has been demonstrated and active site mutant has enhanced activity toward acetylated lysines. HDAC4 does not bind DNA directly, but through transcription factors MEF2C (myocyte enhancer factor-2C) and MEF2D. Other known interaction partners of the protein are 14-3-3 proteins, SMRT and N-CoR co-repressors, BCL6, HP1, SUMO-1 ubiquitin-like protein, and ANKRA2. It appears to interact in a multiprotein complex with RbAp48 and HDAC3. Furthermore, HDAC4 is required for TGFbeta1-induced myofibroblastic differentiation.


Pssm-ID: 212530 [Multi-domain]  Cd Length: 409  Bit Score: 157.89  E-value: 6.22e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 527 TGLVYDQNMMNH-CNLWDSH-HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVgHLRATEKMKTRE 604
Cdd:cd10006     6 TGLVYDTLMLKHqCTCGNSNsHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT-LLYGTNPLNRQK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 605 LHRE------SSNF------------DSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGF 666
Cdd:cd10006    85 LDSKkllgslASVFvrlpcggvgvdsDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGF 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2462627836 667 CFFNSVAVAARHAQTiSGHALRILIVDWDVHHGNGTQHMFEDDPSL 712
Cdd:cd10006   165 CYFNSVAIAAKLLQQ-RLNVSKILIVDWDVHHGNGTQQAFYSDPNV 209
HDAC7 cd10008
Histone deacetylase 7; Histone deacetylase 7 is a class IIa Zn-dependent enzyme that catalyzes ...
 527-712 1.57e-40

Histone deacetylase 7; Histone deacetylase 7 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC7 is involved in regulation of myocyte migration and differentiation. Known interaction partners of class IIa HDAC7 are myocyte enhancer factors - MEF2A, -2C, and -2D, 14-3-3 proteins, SMRT and N-CoR co-repressors, HDAC3, ETA (endothelin receptor). This enzyme is also involved in the development of the immune system as well as brain and heart development. Multiple alternatively spliced transcript variants encoding several isoforms have been found for this gene.


Pssm-ID: 212532 [Multi-domain]  Cd Length: 378  Bit Score: 153.24  E-value: 1.57e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 527 TGLVYDQNMMNH-CNLWD-SHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVgHLRATE-----K 599
Cdd:cd10008     3 TGLVYDSVMLKHqCSCGDnSNHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHV-LLYGTNplsrlK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 600 MKTRELHRESS--------------NFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACG 665
Cdd:cd10008    82 LDNGKLAGLLAqrmfvmlpcggvgvDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMG 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2462627836 666 FCFFNSVAVAARHAQtISGHALRILIVDWDVHHGNGTQHMFEDDPSL 712
Cdd:cd10008   162 FCFFNSVAIACRQLQ-QQGKASKILIVDWDVHHGNGTQQTFYQDPSV 207
HDAC5 cd10007
Histone deacetylase 5; Histone deacetylase 5 is a class IIa Zn-dependent enzyme that catalyzes ...
 527-712 1.86e-40

Histone deacetylase 5; Histone deacetylase 5 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC5 is involved in integration of chronic drug (cocaine) addiction and depression with changes in chromatin structure and gene expression; cocaine regulates HDAC5 function to antagonize the rewarding impact of cocaine, possibly by blocking drug-stimulated gene expression that supports drug-induced behavioral change. It is also involved in regulation of angiogenesis and cell cycle as well as immune system development. HDAC5 and HDAC9 have been found to be significantly up-regulated in high-risk medulloblastoma compared with low-risk and may potentially be novel drug targets.


Pssm-ID: 212531 [Multi-domain]  Cd Length: 420  Bit Score: 153.99  E-value: 1.86e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 527 TGLVYDQNMMNH-CNLWDSH-HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSaEYVGHLRATEKMKTRE 604
Cdd:cd10007     5 TGLVYDTFMLKHqCTCGNTNvHPEHAGRIQSVWSRLQETGLLGKCERVRGRKATLDEIQTVHS-EHHTLLYGTSPLNRQK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 605 LhrESSNF---------------------DSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAA 663
Cdd:cd10007    84 L--DSKKLlgplsqkmyavlpcggigvdsDTVWNEMHSSSAVRMAVGCLIELAFKVAAGELKNGFAVIRPPGHHAEESTA 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2462627836 664 CGFCFFNSVAVAARHAQTISGHAlRILIVDWDVHHGNGTQHMFEDDPSL 712
Cdd:cd10007   162 MGFCFFNSVAIAAKLLQQKLNVG-KILIVDWDIHHGNGTQQAFYNDPNV 209
HDAC_classII_APAH cd10001
Histone deacetylase class IIa; This subfamily includes bacterial acetylpolyamine ...
 545-710 4.37e-38

Histone deacetylase class IIa; This subfamily includes bacterial acetylpolyamine amidohydrolase (APAH) as well as other Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. Mycoplana ramosa APAH exhibits broad substrate specificity and catalyzes the deacetylation of polyamines such as putrescine, spermidine, and spermine by cleavage of a non-peptide amide bond.


Pssm-ID: 212525 [Multi-domain]  Cd Length: 298  Bit Score: 143.83  E-value: 4.37e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 545 HHPEVPQRILRIMCRLEELGLAgrcLTLTPRPATEAELLTCHSAEYVGHLRatekmktrelhressNFD-SIYICPSTFA 623
Cdd:cd10001    24 PHPENPERAEAILDALKRAGLG---EVLPPRDFGLEPILAVHDPDYVDFLE---------------TADtDTPISEGTWE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 624 CAQLATGAACRLVEAVLSGEVLngA-AVVRPPGHHAEQDAACGFCFFNSVAVAARHAqtiSGHALRILIVDWDVHHGNGT 702
Cdd:cd10001    86 AALAAADTALTAADLVLEGERA--AyALCRPPGHHAGRDRAGGFCYFNNAAIAAQYL---RDRAGRVAILDVDVHHGNGT 160


                  ....*...
gi 2462627836 703 QHMFEDDP 710
Cdd:cd10001   161 QEIFYERP 168
HDAC cd09301
Histone deacetylase (HDAC) classes I, II, IV and related proteins; The HDAC/HDAC-like family ...
 552-719 2.62e-35

Histone deacetylase (HDAC) classes I, II, IV and related proteins; The HDAC/HDAC-like family includes Zn-dependent histone deacetylase classes I, II and IV (class III HDACs, also called sirtuins, are NAD-dependent and structurally unrelated, and therefore not part of this family). Histone deacetylases catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98), as opposed to the acetylation reaction by some histone acetyltransferases (EC 2.3.1.48). Deacetylases of this family are involved in signal transduction through histone and other protein modification, and can repress/activate transcription of a number of different genes. They usually act via the formation of large multiprotein complexes. They are involved in various cellular processes, including cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and post-translational control of the acetyl coenzyme A synthetase. In mammals, they are known to be involved in progression of different tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs.


Pssm-ID: 212512 [Multi-domain]  Cd Length: 279  Bit Score: 135.26  E-value: 2.62e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 552 RILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGA 631
Cdd:cd09301     1 RIRDLIEALKELGLRPKIELIECREATEELLLKVHTEEYLNELKANFAVATITESKPVIFGPNFPVQRHYFRGARLSTGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 632 ACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTIsGHAlRILIVDWDVHHGNGTQHMFEDDPS 711
Cdd:cd09301    81 VVEAAELVAKGELERAFAVVGAGGHHAGKSRAWGFCYFNDVVLAIKFLRER-GIS-RILIIDTDAHHGDGTREAFYDDDR 158


                  ....*....
gi 2462627836 712 -LTQNWCWS 719
Cdd:cd09301   159 vLHMSFHNY 167
HDAC_classIV cd09993
Histone deacetylase class IV also known as histone deacetylase 11; Class IV histone ...
 161-448 4.67e-35

Histone deacetylase class IV also known as histone deacetylase 11; Class IV histone deacetylases (HDAC11; EC 3.5.1.98) are predicted Zn-dependent enzymes. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation). They catalyze hydrolysis of N(6)-acetyl-lysine of histones (or other proteins) to yield a deacetylated proteins. Histone deacetylases often act as members of large multi-protein complexes such as mSin3A or SMRT/N-CoR. Human HDAC11 does not associate with them but can interact with HDAC6 in vivo. It has been suggested that HDAC11 and HDAC6 may use non-histone proteins as their substrates and play a role other than to directly modulate chromatin structure. In normal tissues, expression of HDAC11 is limited to kidney, heart, brain, skeletal muscle and testis, suggesting that its function might be tissue-specific. In mammals, HDAC11 proteins are known to be involved in progression of various tumors. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients.


Pssm-ID: 212519 [Multi-domain]  Cd Length: 275  Bit Score: 134.55  E-value: 4.67e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 161 IKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEgELRVLadtydsvyLHPNSyscACLasgsVLRL 240
Cdd:cd09993    11 LREALLEEGLVLPEDIVEPEPATREDLLRVHDPEYLESLKSGELSRE-EIRRI--------GFPWS---PEL----VERT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 241 VDAV----LGAE--IRNGMAIiRPPG--HHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQ 312
Cdd:cd09993    75 RLAVggtiLAARlaLEHGLAI-NLAGgtHHAFPDRGEGFCVFNDIAIAARVLLAEGLVRRVLIVDLDVHQGNGTAAIFAD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 313 DPSVLYFSIHryeQGRFWPHLK-ASNWSttgfgqgqgytINVPWnqvGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGF 391
Cdd:cd09993   154 DPSVFTFSMH---GEKNYPFRKePSDLD-----------VPLPD---GTGDDEYLAALEEALPRLLAEFRPDLVFYNAGV 216

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 392 DALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLI---LSLEGGYNlRALAEGVSASLHTL 448
Cdd:cd09993   217 DVLAGDRLGRLSLSLEGLRERDRLVLRFARARGIpvaMVLGGGYS-RDIARLVARHAQTL 275
HDAC8 cd10000
Histone deacetylase 8 (HDAC8); HDAC8 is a Zn-dependent class I histone deacetylase that ...
 149-434 4.98e-35

Histone deacetylase 8 (HDAC8); HDAC8 is a Zn-dependent class I histone deacetylase that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. HDAC8 is found in human cytoskeleton-bound protein fraction and insoluble cell pellets. It plays a crucial role in intramembraneous bone formation; germline deletion of HDAC8 is detrimental to skull bone formation. HDAC8 is possibly associated with the smooth muscle actin cytockeleton and may regulate the contractive capacity of smooth muscle cells. HDAC8 is also involved in the metabolic control of the estrogen receptor related receptor (ERR)-alpha/peroxisome proliferator activated receptor (PPAR) gamma coactivator 1 alpha (PGC1-alpha) transcriptional complex as well as in the development of neuroblastoma and T-cell lymphoma. HDAC8-selective small-molecule inhibitors could be a therapeutic drug option for these diseases.


Pssm-ID: 212524 [Multi-domain]  Cd Length: 364  Bit Score: 136.70  E-value: 4.98e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 149 DSFPEGPERLHAIkEQLIQE-GLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYM--NEGELRVLAD---TYDSVYL 222
Cdd:cd10000    14 DRLPKVPNRASMV-HSLIEAyGLLKQLRVVKPRVATEEELASFHSDEYIQFLKKASNEgdNDEEPSEQQEfglGYDCPIF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 223 hPNSYSCACLASGSVLRLVDAVLGAEIRngMAIIRPPG-HHAQHSLMDGYCMFNHVAVAARYAqqKHRIRRVLIVDWDVH 301
Cdd:cd10000    93 -EGIYDYAAAVAGATLTAAQLLIDGKCK--VAINWFGGwHHAQRDEASGFCYVNDIVLGILKL--REKFDRVLYVDLDLH 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 302 HGQGTQFTFDQDPSVLYFSIHRYEQGrFWPhlKASNWSTTGFGQGQGYTINVPWNQvGMRDADYIAAFLHVLLPVALEFQ 381
Cdd:cd10000   168 HGDGVEDAFSFTSKVMTVSLHKYSPG-FFP--GTGDVSDVGLGKGKYYTVNVPLRD-GIQDEQYLQIFTAVVPEIVAAFR 243

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462627836 382 PQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSlEGGYNL 434
Cdd:cd10000   244 PEAVVLQCGADTLAGDPMGAFNLTPVGIGKCLKYVLGWKLPTLILG-GGGYNL 295
HDAC9 cd10009
Histone deacetylase 9; Histone deacetylase 9 is a class IIa Zn-dependent enzyme that catalyzes ...
 525-712 3.55e-32

Histone deacetylase 9; Histone deacetylase 9 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, they have N-terminal regulatory domain with two or three conserved serine residues, phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC9 is involved in regulation of gene expression and dendritic growth in developing cortical neurons. It also plays a role in hematopoiesis. Its deregulated expression may be associated with some human cancers. HDAC5 and HDAC9 have been found to be significantly up-regulated in high-risk medulloblastoma compared with low-risk and may potentially be novel drug targets.


Pssm-ID: 212533 [Multi-domain]  Cd Length: 379  Bit Score: 128.98  E-value: 3.55e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 525 SRTGLVYDQNMMNH-CNLWDS-HHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSaEYVGHLRAT----- 597
Cdd:cd10009     1 SATGIAYDPLMLKHqCVCGNStTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHS-EHHSLLYGTnpldg 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 598 EKMKTRELHRESS--------------NFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAA 663
Cdd:cd10009    80 QKLDPRILLGDDSqkffsslpcgglgvDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2462627836 664 CGFCFFNSVAVAARHAQTiSGHALRILIVDWDVHHGNGTQHMFEDDPSL 712
Cdd:cd10009   160 MGFCFFNSVAITAKYLRD-QLNISKILIVDLDVHHGNGTQQAFYADPSI 207
HDAC_classI cd09991
Class I histone deacetylases; Class I histone deacetylases (HDACs) are Zn-dependent enzymes ...
 152-438 5.43e-29

Class I histone deacetylases; Class I histone deacetylases (HDACs) are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. This group includes animal HDAC1, HDAC2, HDAC3, HDAC8, fungal RPD3, HOS1 and HOS2, plant HDA9, protist, archaeal and bacterial (AcuC) deacetylases. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase. In mammals, they are known to be involved in progression of various tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs.


Pssm-ID: 212517 [Multi-domain]  Cd Length: 306  Bit Score: 117.68  E-value: 5.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 152 PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYID-LMETTQ-YMNE--GELRVLADTYDSvYLHPNSY 227
Cdd:cd09991    16 PMKPHRIRMTHSLILSYGLYKKMEIYRPRPATAEELTKFHSDDYIDfLRSVSPdNMKEfkKQLERFNVGEDC-PVFDGLY 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 228 SCACLASGSvlrlvdAVLGAE-IRNGMA--IIRPPG--HHAQHSLMDGYCMFNHVAVAARYAQQKHRirRVLIVDWDVHH 302
Cdd:cd09991    95 EYCQLYAGG------SIAAAVkLNRGQAdiAINWAGglHHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDIDIHH 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 303 GQGTQFTFDQDPSVLYFSIHRYEQGRFwphlkasnwSTTGF-----GQGQGYTINVPWNQvGMRDADYIAAFLHVLLPVA 377
Cdd:cd09991   167 GDGVEEAFYTTDRVMTVSFHKFGEYFF---------PGTGLrdigaGKGKYYAVNVPLKD-GIDDESYLQIFEPVLSKVM 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462627836 378 LEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLaGGKLILSLEGGYNLRALA 438
Cdd:cd09991   237 EVFQPSAVVLQCGADSLAGDRLGCFNLSIKGHAKCVKFVKSF-NIPLLVLGGGGYTLRNVA 296
HDAC_AcuC_like cd09994
Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; AcuC (Acetoin ...
 545-710 5.22e-27

Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; AcuC (Acetoin utilization protein) is a class I deacetylase found only in bacteria and is involved in post-translational control of the acetyl-coenzyme A synthetase (AcsA). Deacetylase AcuC works in coordination with deacetylase SrtN (class III), possibly to maintain AcsA in active (deacetylated) form and let the cell grow under low concentration of acetate. B. subtilis AcuC is a member of operon acuABC; this operon is repressed by the presence of glucose and does not show induction by acetoin; acetoin is a bacterial fermentation product that can be converted to acetate via the butanediol cycle in absence of other carbon sources. Inactivation of AcuC leads to slower growth and lower cell yield under low-acetate conditions in Bacillus subtilis. In general, Class I histone deacetylases (HDACs) are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase.


Pssm-ID: 212520 [Multi-domain]  Cd Length: 313  Bit Score: 112.27  E-value: 5.22e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 545 HHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEK-MKTRELHR------ESSNFDSIYi 617
Cdd:cd09994    16 NHPFNPPRLSLTKDLLRALGLLPPVDLVPPRPATEEELLLFHTPDYIEAVKEASRgQEPEGRGRlglgteDNPVFPGMH- 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 618 cpstfACAQLATGAACRLVEAVLSGEVLNgaaVVRPPG--HHAEQDAACGFCFFNSVAVAARHAQtiSGHALRILIVDWD 695
Cdd:cd09994    95 -----EAAALVVGGTLLAARLVLEGEARR---AFNPAGglHHAMRGRASGFCVYNDAAVAIERLR--DKGGLRVAYVDID 164

                         170
                  ....*....|....*
gi 2462627836 696 VHHGNGTQHMFEDDP 710
Cdd:cd09994   165 AHHGDGVQAAFYDDP 179
HDAC_classIV cd09993
Histone deacetylase class IV also known as histone deacetylase 11; Class IV histone ...
 555-711 3.53e-25

Histone deacetylase class IV also known as histone deacetylase 11; Class IV histone deacetylases (HDAC11; EC 3.5.1.98) are predicted Zn-dependent enzymes. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation). They catalyze hydrolysis of N(6)-acetyl-lysine of histones (or other proteins) to yield a deacetylated proteins. Histone deacetylases often act as members of large multi-protein complexes such as mSin3A or SMRT/N-CoR. Human HDAC11 does not associate with them but can interact with HDAC6 in vivo. It has been suggested that HDAC11 and HDAC6 may use non-histone proteins as their substrates and play a role other than to directly modulate chromatin structure. In normal tissues, expression of HDAC11 is limited to kidney, heart, brain, skeletal muscle and testis, suggesting that its function might be tissue-specific. In mammals, HDAC11 proteins are known to be involved in progression of various tumors. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients.


Pssm-ID: 212519 [Multi-domain]  Cd Length: 275  Bit Score: 105.66  E-value: 3.53e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 555 RIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRatEKMKTRELHRES--SNFDSI-----YICPSTFACAQL 627
Cdd:cd09993    10 LLREALLEEGLVLPEDIVEPEPATREDLLRVHDPEYLESLK--SGELSREEIRRIgfPWSPELvertrLAVGGTILAARL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 628 A--TGAACRLveavlSGevlngaavvrppG-HHAEQDAACGFCFFNSVAVAARHAQTiSGHALRILIVDWDVHHGNGTQH 704
Cdd:cd09993    88 AleHGLAINL-----AG------------GtHHAFPDRGEGFCVFNDIAIAARVLLA-EGLVRRVLIVDLDVHQGNGTAA 149


                  ....*..
gi 2462627836 705 MFEDDPS 711
Cdd:cd09993   150 IFADDPS 156
HDAC_Hos3 cd09998
Class II histone deacetylases Hos3 and related proteins; Fungal histone deacetylase Hos3 from ...
 221-445 4.21e-23

Class II histone deacetylases Hos3 and related proteins; Fungal histone deacetylase Hos3 from Saccharomyces cerevisiae is a Zn-dependent enzyme belonging to HDAC class II. It catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Hos3 deacetylase is homodimer, in vitro it shows specificity to H4, H3 and H2A.


Pssm-ID: 212522 [Multi-domain]  Cd Length: 353  Bit Score: 101.37  E-value: 4.21e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 221 YLHPNSYSCACLASGSVLRLVDAVLGAEI---RNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVD 297
Cdd:cd09998    77 YLCPESLDAIQGALGAVCEAVDSVFKPESpgtKRAFVAIRPPGHHCSESTPSGFCWVNNVHVGAAHAYLTHGITRVVILD 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 298 WDVHHGQGTQ--------FTFDQD----------------PSVLYFSIHRY-----EQGrFWPHLKASNWSTTGfGQGQg 348
Cdd:cd09998   157 IDLHHGNGTQdiawrinaEANKQAlesssyddfkpagapgLRIFYSSLHDInsfpcEDG-DPAKVKDASVSIDG-AHGQ- 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 349 YTINV---PWNQVGMRDADYIAAFlHVLLPVALEF-------QPQ--LVLVAAGFDALQGDPKGeMA----ATPAGF-AQ 411
Cdd:cd09998   234 WIWNVhlqPWTTEEDFWELYYPKY-RILFEKAAEFlrlttaaTPFktLVFISAGFDASEHEYES-MQrhgvNVPTSFyYR 311

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2462627836 412 LT----HLLMGLAGGKLILSLEGGYNLRALAEGVSASL 445
Cdd:cd09998   312 FArdavRFADAHAHGRLISVLEGGYSDRALCSGVLAHL 349
HDAC_Hos1 cd11680
Class I histone deacetylases Hos1 and related proteins; Saccharomyces cerevisiae Hos1 is ...
 162-433 1.07e-22

Class I histone deacetylases Hos1 and related proteins; Saccharomyces cerevisiae Hos1 is responsible for Smc3 deacetylation. Smc3 is an important player during the establishment of sister chromatid cohesion. Hos1 belongs to the class I histone deacetylases (HDACs). HDACs are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. Other class I HDACs are animal HDAC1, HDAC2, HDAC3, HDAC8, fungal RPD3 and HOS2, plant HDA9, protist, archaeal and bacterial (AcuC) deacetylases. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase.


Pssm-ID: 212543 [Multi-domain]  Cd Length: 294  Bit Score: 98.88  E-value: 1.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 162 KEQLIQE-----GLLDRCV-SFQARFAEKEELMLVHSLEYIDLMeTTQYMNEGelrvlaDTYDSVYLHpnSYscACLASG 235
Cdd:cd11680    21 RSSLVHSlirayGLLQHFDeIIEPERATRKDLTKYHDKDYVDFL-LKKYGLED------DCPVFPFLS--MY--VQLVAG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 236 SVLRLVDAVLGAEIRNgMAIIRPPG-HHAQHSLMDGYCMFNHVaVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDP 314
Cdd:cd11680    90 SSLALAKHLITQVERD-IAINWYGGrHHAQKSRASGFCYVNDI-VLAILRLRRARFRRVFYLDLDLHHGDGVESAFFFSK 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 315 SVLYFSIHRYEQGrFWPHLKASNWSTTGFgqgqgyTINVPWNQvGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDAL 394
Cdd:cd11680   168 NVLTCSIHRYDPG-FFPGTGSLKNSSDKG------MLNIPLKR-GLSDKTLLRIIDSIVRPLIEKFEPEVIVIQCGCDGL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2462627836 395 QGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSL-EGGYN 433
Cdd:cd11680   240 SGDPHKEWNLTIRGYGSVIELLLKEFKDKPTLLLgGGGYN 279
HDAC_Hos2 cd11598
Class I histone deacetylases including ScHos2 and SpPhd1; This subfamily includes Class I ...
 136-438 2.53e-21

Class I histone deacetylases including ScHos2 and SpPhd1; This subfamily includes Class I histone deacetylase (HDAC) Hos2 from Saccharomyces cerevisiae as well as a histone deacetylase Phd1 from Schizosaccharomyces pombe. Hos2 binds to the coding regions of genes during gene activation, specifically it deacetylates the lysines in H3 and H4 histone tails. It is preferentially associated with genes of high activity genome-wide and is shown to be necessary for efficient transcription. Thus, Hos2 is directly required for gene activation in contrast to other class I histone deacetylases. Protein encoded by phd1 is inhibited by trichostatin A (TSA), a specific inhibitor of histone deacetylase, and is involved in the meiotic cell cycle in S. pombe. Class 1 HDACs are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98).


Pssm-ID: 212540 [Multi-domain]  Cd Length: 311  Bit Score: 95.21  E-value: 2.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 136 LDEQLNEFHclWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLM-----ETTQYMNEGEL 210
Cdd:cd11598     5 FNSRVEDYH--FGRTHPMKPFRLTLTKHLVMGYGLHKAMDTYEARAATREELRQFHDADYLDFLskvspENANQLRFDKA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 211 RVLADTYDSVYLHpNSYSCACLASGSVLrlvDAVlgAEIRNG---MAIIRPPG-HHAQHSLMDGYCMFNHVAVAA----R 282
Cdd:cd11598    83 EPFNIGDDCPVFD-GMYDYCQLYAGASL---DAA--RKLCSGqsdIAINWSGGlHHAKKSEASGFCYVNDIVLAIlnllR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 283 YaqqkhrIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYeQGRFWPhlKASNWSTTGFGQGQGYTINVPWNQvGMRD 362
Cdd:cd11598   157 Y------FPRVLYIDIDVHHGDGVEEAFYRTDRVMTLSFHKY-NGEFFP--GTGDLDDNGGTPGKHFALNVPLED-GIDD 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 363 ADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMA------ATPAGFAQLTHLLMGLAGGklilsleGGYNLRA 436
Cdd:cd11598   227 EQYNLLFKSIIGPTIEKFQPSAIVLQCGADSLGGDRLGQFNlnikahGACVKFVKSFGIPMLVVGG-------GGYTPRN 299


                  ..
gi 2462627836 437 LA 438
Cdd:cd11598   300 VA 301
HDAC1 cd10010
Histone deacetylase 1 (HDAC1); Histone deacetylase 1 (HDAC1) is a Zn-dependent class I enzyme ...
 152-438 1.10e-20

Histone deacetylase 1 (HDAC1); Histone deacetylase 1 (HDAC1) is a Zn-dependent class I enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDAC1 is involved in regulation through association with DNA binding proteins to target specific chromatin regions. In particular, HDAC1 appears to play a major role in pre-implantation embryogenesis in establishing a repressive chromatin state. Its interaction with retinoblastoma tumor-suppressor protein is essential in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 (MTA2), it deacetylates p53, thereby modulating its effect on cell growth and apoptosis. It participates in DNA-damage response, along with HDAC2; together, they promote DNA non-homologous end-joining. HDAC1 is also involved in tumorogenesis; its overexpression modulates cancer progression. Specific inhibitors of HDAC1 are currently used in cancer therapy.


Pssm-ID: 212534 [Multi-domain]  Cd Length: 371  Bit Score: 94.75  E-value: 1.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 152 PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGE-------LRVLAD--TYDSVYL 222
Cdd:cd10010    26 PMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEyskqmqrFNVGEDcpVFDGLFE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 223 HPNSYSCACLASGSVLRLVDAVLGAEIRNGMaiirppgHHAQHSLMDGYCMFNHVAVAARYAQQKHRirRVLIVDWDVHH 302
Cdd:cd10010   106 FCQLSAGGSVASAVKLNKQQTDIAVNWAGGL-------HHAKKSEASGFCYVNDIVLAILELLKYHQ--RVLYIDIDIHH 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 303 GQGTQFTFDQDPSVLYFSIHRYeqGRFWPhlKASNWSTTGFGQGQGYTINVPWNQvGMRDADYIAAFLHVLLPVALEFQP 382
Cdd:cd10010   177 GDGVEEAFYTTDRVMTVSFHKY--GEYFP--GTGDLRDIGAGKGKYYAVNYPLRD-GIDDESYEAIFKPVMSKVMEMFQP 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462627836 383 QLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSlEGGYNLRALA 438
Cdd:cd10010   252 SAVVLQCGADSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLG-GGGYTIRNVA 306
RPD3-like cd10004
reduced potassium dependency-3 (RPD3)-like; Proteins of the Rpd3-like family are class I ...
 152-438 3.74e-20

reduced potassium dependency-3 (RPD3)-like; Proteins of the Rpd3-like family are class I Zn-dependent Histone deacetylases that catalyze hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). RPD3 is the yeast homolog of class I HDACs. The main function of RPD3-like group members is regulation of a number of different processes through protein (mostly different histones) modification (deacetylation). This group includes fungal RPD3 and acts via the formation of large multiprotein complexes. Members of this group are involved in cell cycle regulation, DNA damage response, embryonic development and cytokine signaling important for immune response. Histone deacetylation by yeast RPD3 represses genes regulated by the Ash1 and Ume6 DNA-binding proteins. In mammals, they are known to be involved in progression of various tumors. Specific inhibitors of mammalian histone deacetylases could be a therapeutic drug option.


Pssm-ID: 212528 [Multi-domain]  Cd Length: 375  Bit Score: 92.95  E-value: 3.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 152 PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMEttqymnegelRVLADTYDSVYLHPNSYS--- 228
Cdd:cd10004    22 PMKPHRIRMAHSLVMNYGLYKKMEIYRAKPATKNEMTQFHTDEYIDFLS----------RVTPDNMEKFQKEQVKYNvgd 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 229 -----------CACLASGSVLRlvdavlGAEIRNG---MAIIRPPG-HHAQHSLMDGYCMFNHVAVAA----RYAQqkhr 289
Cdd:cd10004    92 dcpvfdglfefCSISAGGSMEG------AARLNRGkcdIAVNWAGGlHHAKKSEASGFCYVNDIVLGIlellRYHQ---- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 290 irRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYeqGRFWP---HLKasnwsTTGFGQGQGYTINVPWNQvGMRDADYI 366
Cdd:cd10004   162 --RVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKY--GEYFPgtgELR-----DIGIGTGKNYAVNVPLRD-GIDDESYK 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462627836 367 AAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKG------EMAATPAGFAQLTHLLMGLAGGklilsleGGYNLRALA 438
Cdd:cd10004   232 SIFEPVIKHVMEWYQPEAVVLQCGGDSLSGDRLGcfnlsmKGHANCVNFVKSFNLPMLVLGG-------GGYTMRNVA 302
HDAC8 cd10000
Histone deacetylase 8 (HDAC8); HDAC8 is a Zn-dependent class I histone deacetylase that ...
 529-711 1.07e-18

Histone deacetylase 8 (HDAC8); HDAC8 is a Zn-dependent class I histone deacetylase that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. HDAC8 is found in human cytoskeleton-bound protein fraction and insoluble cell pellets. It plays a crucial role in intramembraneous bone formation; germline deletion of HDAC8 is detrimental to skull bone formation. HDAC8 is possibly associated with the smooth muscle actin cytockeleton and may regulate the contractive capacity of smooth muscle cells. HDAC8 is also involved in the metabolic control of the estrogen receptor related receptor (ERR)-alpha/peroxisome proliferator activated receptor (PPAR) gamma coactivator 1 alpha (PGC1-alpha) transcriptional complex as well as in the development of neuroblastoma and T-cell lymphoma. HDAC8-selective small-molecule inhibitors could be a therapeutic drug option for these diseases.


Pssm-ID: 212524 [Multi-domain]  Cd Length: 364  Bit Score: 88.55  E-value: 1.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 529 LVYDQNMMNHCNlwdsHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLR-ATEKMKTRELHR 607
Cdd:cd10000     3 YIHSPEYVNLCD----RLPKVPNRASMVHSLIEAYGLLKQLRVVKPRVATEEELASFHSDEYIQFLKkASNEGDNDEEPS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 608 ESSNFDSIYICPST---FACAQLATGAACRLVEAVLSGEVlngAAVVRPPG--HHAEQDAACGFCFFNSVAVAArhaQTI 682
Cdd:cd10000    79 EQQEFGLGYDCPIFegiYDYAAAVAGATLTAAQLLIDGKC---KVAINWFGgwHHAQRDEASGFCYVNDIVLGI---LKL 152

                         170       180
                  ....*....|....*....|....*....
gi 2462627836 683 SGHALRILIVDWDVHHGNGTQHMFEDDPS 711
Cdd:cd10000   153 REKFDRVLYVDLDLHHGDGVEDAFSFTSK 181
HDAC_Hos3 cd09998
Class II histone deacetylases Hos3 and related proteins; Fungal histone deacetylase Hos3 from ...
 615-703 2.53e-18

Class II histone deacetylases Hos3 and related proteins; Fungal histone deacetylase Hos3 from Saccharomyces cerevisiae is a Zn-dependent enzyme belonging to HDAC class II. It catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Hos3 deacetylase is homodimer, in vitro it shows specificity to H4, H3 and H2A.


Pssm-ID: 212522 [Multi-domain]  Cd Length: 353  Bit Score: 87.12  E-value: 2.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 615 IYICPSTFACAQLATGAACRLVEAVLSGEVL--NGAAV-VRPPGHHAEQDAACGFCFFNSVAVAARHAqtISGHAL-RIL 690
Cdd:cd09998    76 LYLCPESLDAIQGALGAVCEAVDSVFKPESPgtKRAFVaIRPPGHHCSESTPSGFCWVNNVHVGAAHA--YLTHGItRVV 153

                          90
                  ....*....|...
gi 2462627836 691 IVDWDVHHGNGTQ 703
Cdd:cd09998   154 ILDIDLHHGNGTQ 166
HDAC_classI cd09991
Class I histone deacetylases; Class I histone deacetylases (HDACs) are Zn-dependent enzymes ...
 545-706 6.48e-18

Class I histone deacetylases; Class I histone deacetylases (HDACs) are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. This group includes animal HDAC1, HDAC2, HDAC3, HDAC8, fungal RPD3, HOS1 and HOS2, plant HDA9, protist, archaeal and bacterial (AcuC) deacetylases. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase. In mammals, they are known to be involved in progression of various tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs.


Pssm-ID: 212517 [Multi-domain]  Cd Length: 306  Bit Score: 85.33  E-value: 6.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 545 HHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPST--- 621
Cdd:cd09991    14 GHPMKPHRIRMTHSLILSYGLYKKMEIYRPRPATAEELTKFHSDDYIDFLRSVSPDNMKEFKKQLERFNVGEDCPVFdgl 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 622 FACAQLATGAACRLVEAVLSGevlNGAAVVRPPG--HHAEQDAACGFCFFNSVAVA-----ARHAqtisghalRILIVDW 694
Cdd:cd09991    94 YEYCQLYAGGSIAAAVKLNRG---QADIAINWAGglHHAKKSEASGFCYVNDIVLAilellKYHQ--------RVLYIDI 162

                         170
                  ....*....|..
gi 2462627836 695 DVHHGNGTQHMF 706
Cdd:cd09991   163 DIHHGDGVEEAF 174
PTZ00063 PTZ00063
histone deacetylase; Provisional
 261-455 4.64e-16

histone deacetylase; Provisional


Pssm-ID: 240251  Cd Length: 436  Bit Score: 81.40  E-value: 4.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 261 HHAQHSLMDGYCMFNHVAVAARYAQQKHRirRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYeqGRFWPhlKASNWST 340
Cdd:PTZ00063  137 HHAKRSEASGFCYINDIVLGILELLKYHA--RVMYIDIDVHHGDGVEEAFYVTHRVMTVSFHKF--GDFFP--GTGDVTD 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 341 TGFGQGQGYTINVPWNQvGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLA 420
Cdd:PTZ00063  211 IGVAQGKYYSVNVPLND-GIDDDSFVDLFKPVISKCVEVYRPGAIVLQCGADSLTGDRLGRFNLTIKGHAACVEFVRSLN 289

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2462627836 421 GGKLILSlEGGYNLRALAE------GVSASLHTLLGDPCPM 455
Cdd:PTZ00063  290 IPLLVLG-GGGYTIRNVARcwayetGVILNKHDEMSDQISL 329
HDAC2 cd10011
Histone deacetylase 2 (HDAC2); Histone deacetylase 2 (HDAC2) is a Zn-dependent class I enzyme ...
 152-438 9.72e-16

Histone deacetylase 2 (HDAC2); Histone deacetylase 2 (HDAC2) is a Zn-dependent class I enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDAC2 is involved in regulation through association with DNA binding proteins to target specific chromatin regions. It forms transcriptional repressor complexes by associating with several proteins, including the mammalian zinc-finger transcription factor YY1, thus playing an important role in transcriptional regulation, cell cycle progression and developmental events. Additionally, a few non-histone HDAC2 substrates have been found. HDAC2 plays a role in embryonic development and cytokine signaling important for immune response, and is over-expressed in several solid tumors including oral, prostate, ovarian, endometrial and gastric cancer. It participates in DNA-damage response, along with HDAC1; together, they can promote DNA non-homologous end-joining. HDAC2 is considered an important cancer prognostic marker. Inhibitors specifically targeting HDAC2 could be a therapeutic drug option.


Pssm-ID: 212535 [Multi-domain]  Cd Length: 366  Bit Score: 79.72  E-value: 9.72e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 152 PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGE-------LRVLAD--TYDSVYL 222
Cdd:cd10011    22 PMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEyskqmqrFNVGEDcpVFDGLFE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 223 HpnsysCACLASGSVlrlVDAVLGAEIRNGMAIIRPPG-HHAQHSLMDGYCMFNHVAVAARYAQQKHriRRVLIVDWDVH 301
Cdd:cd10011   102 F-----CQLSTGGSV---AGAVKLNRQQTDMAVNWAGGlHHAKKSEASGFCYVNDIVLAILELLKYH--QRVLYIDIDIH 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 302 HGQGTQFTFDQDPSVLyfSIHRYEQGRFWPhlKASNWSTTGFGQGQGYTINVPWNQvGMRDADYIAAFLHVLLPVALEFQ 381
Cdd:cd10011   172 HGDGVEEAFYTTDRVM--TVSFHKYGEYFP--GTGDLRDIGAGKGKYYAVNFPMRD-GIDDESYGQIFKPIISKVMEMYQ 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462627836 382 PQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSlEGGYNLRALA 438
Cdd:cd10011   247 PSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG-GGGYTIRNVA 302
HDAC3 cd10005
Histone deacetylase 3 (HDAC3); HDAC3 is a Zn-dependent class I histone deacetylase that ...
 137-438 4.48e-15

Histone deacetylase 3 (HDAC3); HDAC3 is a Zn-dependent class I histone deacetylase that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. In order to target specific chromatin regions, HDAC3 can interact with DNA-binding proteins (transcriptional factors) either directly or after forming complexes with a number of other proteins, as observed for the SMPT/N-CoR complex which recruits human HDAC3 to specific chromatin loci and activates deacetylation. Human HDAC3 is also involved in deacetylation of non-histone substrates such as RelA, SPY and p53 factors. This protein can also down-regulate p53 function and subsequently modulate cell growth and apoptosis. This gene is therefore regarded as a potential tumor suppressor gene. HDAC3 plays a role in various physiological processes, including subcellular protein localization, cell cycle progression, cell differentiation, apoptosis and survival. HDAC3 has been found to be overexpressed in some tumors including leukemia, lung carcinoma, colon cancer and maxillary carcinoma. Thus, inhibitors precisely targeting HDAC3 (in some cases together with retinoic acid or hyperthermia) could be a therapeutic drug option.


Pssm-ID: 212529  Cd Length: 381  Bit Score: 77.82  E-value: 4.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 137 DEQLNEFHclWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLME--TTQYMNE-----GE 209
Cdd:cd10005     8 DPDVGNFH--YGPGHPMKPHRLALTHSLVLHYGLYKKMQVYKPYRASAHDMCRFHSEDYIDFLQrvTPQNIQGftkslNQ 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 210 LRVLAD--TYDSVYLHPNSYSCACLaSGSVlrlvdavlgaEIRNGM---AIIRPPG-HHAQHSLMDGYCMFNHVAVAARY 283
Cdd:cd10005    86 FNVGDDcpVFPGLFDFCSMYTGASL-EGAT----------KLNHKIcdiAINWSGGlHHAKKFEASGFCYVNDIVIAILE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 284 AQQKHRirRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYeQGRFWPhlKASNWSTTGFGQGQGYTINVPWNQvGMRDA 363
Cdd:cd10005   155 LLKYHP--RVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKY-GNYFFP--GTGDMYEVGAESGRYYSVNVPLKD-GIDDQ 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462627836 364 DYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSlEGGYNLRALA 438
Cdd:cd10005   229 SYLQLFKPVIQQVIDFYQPTCIVLQCGADSLGCDRLGCFNLSIKGHGECVEFVKSFNIPLLVLG-GGGYTVRNVA 302
PTZ00346 PTZ00346
histone deacetylase; Provisional
 261-455 2.15e-13

histone deacetylase; Provisional


Pssm-ID: 240374 [Multi-domain]  Cd Length: 429  Bit Score: 72.76  E-value: 2.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 261 HHAQHSLMDGYCMFNHVAVAARYAQQKHRirRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGrFWPhlKASNWST 340
Cdd:PTZ00346  154 HHSKCGECSGFCYVNDIVLGILELLKCHD--RVLYVDIDMHHGDGVDEAFCTSDRVFTLSLHKFGES-FFP--GTGHPRD 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 341 TGFGQGQGYTINVP-WNqvGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGL 419
Cdd:PTZ00346  229 VGYGRGRYYSMNLAvWD--GITDFYYLGLFEHALHSIVRRYSPDAIVLQCGADSLAGDRLGLLNLSSFGHGQCVQAVRDL 306

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2462627836 420 AGGKLILSlEGGYNLRALAEGVSASLHTLLGDPCPM 455
Cdd:PTZ00346  307 GIPMLALG-GGGYTIRNVAKLWAYETSILTGHPLPP 341
HDAC2 cd10011
Histone deacetylase 2 (HDAC2); Histone deacetylase 2 (HDAC2) is a Zn-dependent class I enzyme ...
 531-706 3.47e-13

Histone deacetylase 2 (HDAC2); Histone deacetylase 2 (HDAC2) is a Zn-dependent class I enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDAC2 is involved in regulation through association with DNA binding proteins to target specific chromatin regions. It forms transcriptional repressor complexes by associating with several proteins, including the mammalian zinc-finger transcription factor YY1, thus playing an important role in transcriptional regulation, cell cycle progression and developmental events. Additionally, a few non-histone HDAC2 substrates have been found. HDAC2 plays a role in embryonic development and cytokine signaling important for immune response, and is over-expressed in several solid tumors including oral, prostate, ovarian, endometrial and gastric cancer. It participates in DNA-damage response, along with HDAC1; together, they can promote DNA non-homologous end-joining. HDAC2 is considered an important cancer prognostic marker. Inhibitors specifically targeting HDAC2 could be a therapeutic drug option.


Pssm-ID: 212535 [Multi-domain]  Cd Length: 366  Bit Score: 71.63  E-value: 3.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 531 YDQNMMNHcnLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESS 610
Cdd:cd10011     8 YDGDIGNY--YYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQ 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 611 NFDSIYICP---STFACAQLATGAAcrLVEAVLSGEVLNGAAVVRPPG-HHAEQDAACGFCFFNSVAVAArhAQTISGHA 686
Cdd:cd10011    86 RFNVGEDCPvfdGLFEFCQLSTGGS--VAGAVKLNRQQTDMAVNWAGGlHHAKKSEASGFCYVNDIVLAI--LELLKYHQ 161

                         170       180
                  ....*....|....*....|
gi 2462627836 687 lRILIVDWDVHHGNGTQHMF 706
Cdd:cd10011   162 -RVLYIDIDIHHGDGVEEAF 180
HDAC1 cd10010
Histone deacetylase 1 (HDAC1); Histone deacetylase 1 (HDAC1) is a Zn-dependent class I enzyme ...
 531-706 6.74e-12

Histone deacetylase 1 (HDAC1); Histone deacetylase 1 (HDAC1) is a Zn-dependent class I enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDAC1 is involved in regulation through association with DNA binding proteins to target specific chromatin regions. In particular, HDAC1 appears to play a major role in pre-implantation embryogenesis in establishing a repressive chromatin state. Its interaction with retinoblastoma tumor-suppressor protein is essential in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 (MTA2), it deacetylates p53, thereby modulating its effect on cell growth and apoptosis. It participates in DNA-damage response, along with HDAC2; together, they promote DNA non-homologous end-joining. HDAC1 is also involved in tumorogenesis; its overexpression modulates cancer progression. Specific inhibitors of HDAC1 are currently used in cancer therapy.


Pssm-ID: 212534 [Multi-domain]  Cd Length: 371  Bit Score: 67.78  E-value: 6.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 531 YDQNMMNHcnLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESS 610
Cdd:cd10010    12 YDGDVGNY--YYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 611 NFDSIYICP---STFACAQLATGAAcrLVEAVLSGEVLNGAAVVRPPG-HHAEQDAACGFCFFNSVAVAArhAQTISGHA 686
Cdd:cd10010    90 RFNVGEDCPvfdGLFEFCQLSAGGS--VASAVKLNKQQTDIAVNWAGGlHHAKKSEASGFCYVNDIVLAI--LELLKYHQ 165

                         170       180
                  ....*....|....*....|
gi 2462627836 687 lRILIVDWDVHHGNGTQHMF 706
Cdd:cd10010   166 -RVLYIDIDIHHGDGVEEAF 184
RPD3-like cd10004
reduced potassium dependency-3 (RPD3)-like; Proteins of the Rpd3-like family are class I ...
 526-706 3.45e-10

reduced potassium dependency-3 (RPD3)-like; Proteins of the Rpd3-like family are class I Zn-dependent Histone deacetylases that catalyze hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). RPD3 is the yeast homolog of class I HDACs. The main function of RPD3-like group members is regulation of a number of different processes through protein (mostly different histones) modification (deacetylation). This group includes fungal RPD3 and acts via the formation of large multiprotein complexes. Members of this group are involved in cell cycle regulation, DNA damage response, embryonic development and cytokine signaling important for immune response. Histone deacetylation by yeast RPD3 represses genes regulated by the Ash1 and Ume6 DNA-binding proteins. In mammals, they are known to be involved in progression of various tumors. Specific inhibitors of mammalian histone deacetylases could be a therapeutic drug option.


Pssm-ID: 212528 [Multi-domain]  Cd Length: 375  Bit Score: 62.52  E-value: 3.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 526 RTGLVYDQNMMNHCnlWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTREL 605
Cdd:cd10004     3 KVAYFYDSDVGNYA--YGPGHPMKPHRIRMAHSLVMNYGLYKKMEIYRAKPATKNEMTQFHTDEYIDFLSRVTPDNMEKF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 606 HRESSNFDSIYICP---STFACAQLATGAACRLVEAVLSGE---VLNGAAVVrppgHHAEQDAACGFCFFNSVAVAA--- 676
Cdd:cd10004    81 QKEQVKYNVGDDCPvfdGLFEFCSISAGGSMEGAARLNRGKcdiAVNWAGGL----HHAKKSEASGFCYVNDIVLGIlel 156

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2462627836 677 -RHAQtisghalRILIVDWDVHHGNGTQHMF 706
Cdd:cd10004   157 lRYHQ-------RVLYIDIDVHHGDGVEEAF 180
HDAC3 cd10005
Histone deacetylase 3 (HDAC3); HDAC3 is a Zn-dependent class I histone deacetylase that ...
 546-706 4.88e-10

Histone deacetylase 3 (HDAC3); HDAC3 is a Zn-dependent class I histone deacetylase that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. In order to target specific chromatin regions, HDAC3 can interact with DNA-binding proteins (transcriptional factors) either directly or after forming complexes with a number of other proteins, as observed for the SMPT/N-CoR complex which recruits human HDAC3 to specific chromatin loci and activates deacetylation. Human HDAC3 is also involved in deacetylation of non-histone substrates such as RelA, SPY and p53 factors. This protein can also down-regulate p53 function and subsequently modulate cell growth and apoptosis. This gene is therefore regarded as a potential tumor suppressor gene. HDAC3 plays a role in various physiological processes, including subcellular protein localization, cell cycle progression, cell differentiation, apoptosis and survival. HDAC3 has been found to be overexpressed in some tumors including leukemia, lung carcinoma, colon cancer and maxillary carcinoma. Thus, inhibitors precisely targeting HDAC3 (in some cases together with retinoic acid or hyperthermia) could be a therapeutic drug option.


Pssm-ID: 212529  Cd Length: 381  Bit Score: 62.03  E-value: 4.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 546 HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICP---STF 622
Cdd:cd10005    20 HPMKPHRLALTHSLVLHYGLYKKMQVYKPYRASAHDMCRFHSEDYIDFLQRVTPQNIQGFTKSLNQFNVGDDCPvfpGLF 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 623 ACAQLATGAAcrlveavLSGEV-LNGA----AVVRPPG-HHAEQDAACGFCFFNSVAVAArhAQTISGHAlRILIVDWDV 696
Cdd:cd10005   100 DFCSMYTGAS-------LEGATkLNHKicdiAINWSGGlHHAKKFEASGFCYVNDIVIAI--LELLKYHP-RVLYIDIDI 169

                         170
                  ....*....|
gi 2462627836 697 HHGNGTQHMF 706
Cdd:cd10005   170 HHGDGVQEAF 179
HDAC_Hos2 cd11598
Class I histone deacetylases including ScHos2 and SpPhd1; This subfamily includes Class I ...
 546-710 7.77e-10

Class I histone deacetylases including ScHos2 and SpPhd1; This subfamily includes Class I histone deacetylase (HDAC) Hos2 from Saccharomyces cerevisiae as well as a histone deacetylase Phd1 from Schizosaccharomyces pombe. Hos2 binds to the coding regions of genes during gene activation, specifically it deacetylates the lysines in H3 and H4 histone tails. It is preferentially associated with genes of high activity genome-wide and is shown to be necessary for efficient transcription. Thus, Hos2 is directly required for gene activation in contrast to other class I histone deacetylases. Protein encoded by phd1 is inhibited by trichostatin A (TSA), a specific inhibitor of histone deacetylase, and is involved in the meiotic cell cycle in S. pombe. Class 1 HDACs are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98).


Pssm-ID: 212540 [Multi-domain]  Cd Length: 311  Bit Score: 60.93  E-value: 7.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 546 HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHL-RATEKMKTRELHRESSNFDSIYICP---ST 621
Cdd:cd11598    18 HPMKPFRLTLTKHLVMGYGLHKAMDTYEARAATREELRQFHDADYLDFLsKVSPENANQLRFDKAEPFNIGDDCPvfdGM 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 622 FACAQLATGAACRLVEAVLSGEvlNGAAVVRPPG-HHAEQDAACGFCFFNSVAVAArhAQTISGHAlRILIVDWDVHHGN 700
Cdd:cd11598    98 YDYCQLYAGASLDAARKLCSGQ--SDIAINWSGGlHHAKKSEASGFCYVNDIVLAI--LNLLRYFP-RVLYIDIDVHHGD 172

                         170
                  ....*....|
gi 2462627836 701 GTQHMFEDDP 710
Cdd:cd11598   173 GVEEAFYRTD 182
Arginase_HDAC cd09987
Arginase-like and histone-like hydrolases; Arginase-like/histone-like hydrolase superfamily ...
 260-451 4.24e-08

Arginase-like and histone-like hydrolases; Arginase-like/histone-like hydrolase superfamily includes metal-dependent enzymes that belong to Arginase-like amidino hydrolase family and histone/histone-like deacetylase class I, II, IV family, respectively. These enzymes catalyze hydrolysis of amide bond. Arginases are known to be involved in control of cellular levels of arginine and ornithine, in histidine and arginine degradation and in clavulanic acid biosynthesis. Deacetylases play a role in signal transduction through histone and/or other protein modification and can repress/activate transcription of a number of different genes. They participate in different cellular processes including cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and post-translational control of the acetyl coenzyme A synthetase. Mammalian histone deacetyases are known to be involved in progression of different tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs.


Pssm-ID: 212513  Cd Length: 217  Bit Score: 54.30  E-value: 4.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 260 GHHAqhslmdgycMFNHVAVAARYAQQkhrirRVLIVDWDVHHGQGTQFTF--------------DQDPSVLYFSIHRYE 325
Cdd:cd09987    33 GDHS---------IANGAIRAVAELHP-----DLGVIDVDAHHDVRTPEAFgkgnhhtprhllcePLISDVHIVSIGIRG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 326 QGRFWPHlkasnwsttGFGQGQGYTINVPWNQVgmRDADYIAAFLHVLLPValEFQPQLVLVAAGFDALQGDPkGEMAAT 405
Cdd:cd09987    99 VSNGEAG---------GAYARKLGVVYFSMTEV--DKLGLGDVFEEIVSYL--GDKGDNVYLSVDVDGLDPSF-APGTGT 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2462627836 406 PAGFaqlthllmGLA--GGKLILSLEGGYNLRALAEGVsaSLHTLLGD 451
Cdd:cd09987   165 PGPG--------GLSyrEGLYITERIAKTNLVVGLDIV--EVNPLLDE 202
PTZ00063 PTZ00063
histone deacetylase; Provisional
 546-706 2.38e-07

histone deacetylase; Provisional


Pssm-ID: 240251  Cd Length: 436  Bit Score: 53.66  E-value: 2.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 546 HPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRE----LHR----ESSN---FDS 614
Cdd:PTZ00063   23 HPMKPQRIRMAHALILSYDLYKHMEIYRPHKSVEPELVLFHDEEYVDFLSSISPENYRDftyqLKRfnvgEATDcpvFDG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 615 IYicpsTF--ACAQLATGAACRL------VEAVLSGEVlngaavvrppgHHAEQDAACGFCFFNSVAVAArhAQTISGHA 686
Cdd:PTZ00063  103 LF----EFqqSCAGASIDGAYKLnnhqadICVNWSGGL-----------HHAKRSEASGFCYINDIVLGI--LELLKYHA 165

                         170       180
                  ....*....|....*....|
gi 2462627836 687 lRILIVDWDVHHGNGTQHMF 706
Cdd:PTZ00063  166 -RVMYIDIDVHHGDGVEEAF 184
HDAC_Hos1 cd11680
Class I histone deacetylases Hos1 and related proteins; Saccharomyces cerevisiae Hos1 is ...
 568-707 8.04e-06

Class I histone deacetylases Hos1 and related proteins; Saccharomyces cerevisiae Hos1 is responsible for Smc3 deacetylation. Smc3 is an important player during the establishment of sister chromatid cohesion. Hos1 belongs to the class I histone deacetylases (HDACs). HDACs are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. Other class I HDACs are animal HDAC1, HDAC2, HDAC3, HDAC8, fungal RPD3 and HOS2, plant HDA9, protist, archaeal and bacterial (AcuC) deacetylases. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase.


Pssm-ID: 212543 [Multi-domain]  Cd Length: 294  Bit Score: 48.42  E-value: 8.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 568 RCLTLTPRPATEAELLTCHSAEYVGHLratekmktreLHRESSNFDSiYICPSTFACAQLATGAACRLVEAVLSGEvlnG 647
Cdd:cd11680    38 FDEIIEPERATRKDLTKYHDKDYVDFL----------LKKYGLEDDC-PVFPFLSMYVQLVAGSSLALAKHLITQV---E 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462627836 648 AAVV------RppgHHAEQDAACGFCFFNSVAVAARHAQtiSGHALRILIVDWDVHHGNGTQHMFE 707
Cdd:cd11680   104 RDIAinwyggR---HHAQKSRASGFCYVNDIVLAILRLR--RARFRRVFYLDLDLHHGDGVESAFF 164
PTZ00346 PTZ00346
histone deacetylase; Provisional
 545-706 3.88e-04

histone deacetylase; Provisional


Pssm-ID: 240374 [Multi-domain]  Cd Length: 429  Bit Score: 43.48  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 545 HHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLrATEKMKTRELHRESSNFDSIYICPSTFAC 624
Cdd:PTZ00346   42 QHAMKPYRVLAAMEIVRSLKIDAHCRTVVPPLVKVEELMAYHTDTYLANL-GLHSCRSWLWNAETSKVFFSGDCPPVEGL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 625 AQLATGAAC-RLVEAVL--SGEVlnGAAVVRPPG-HHAEQDAACGFCFFNSVAVAArhAQTISGHAlRILIVDWDVHHGN 700
Cdd:PTZ00346  121 MEHSIATASgTLMGAVLlnSGQV--DVAVHWGGGmHHSKCGECSGFCYVNDIVLGI--LELLKCHD-RVLYVDIDMHHGD 195


                  ....*.
gi 2462627836 701 GTQHMF 706
Cdd:PTZ00346  196 GVDEAF 201
Arginase_HDAC cd09987
Arginase-like and histone-like hydrolases; Arginase-like/histone-like hydrolase superfamily ...
 632-721 6.27e-03

Arginase-like and histone-like hydrolases; Arginase-like/histone-like hydrolase superfamily includes metal-dependent enzymes that belong to Arginase-like amidino hydrolase family and histone/histone-like deacetylase class I, II, IV family, respectively. These enzymes catalyze hydrolysis of amide bond. Arginases are known to be involved in control of cellular levels of arginine and ornithine, in histidine and arginine degradation and in clavulanic acid biosynthesis. Deacetylases play a role in signal transduction through histone and/or other protein modification and can repress/activate transcription of a number of different genes. They participate in different cellular processes including cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and post-translational control of the acetyl coenzyme A synthetase. Mammalian histone deacetyases are known to be involved in progression of different tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs.


Pssm-ID: 212513  Cd Length: 217  Bit Score: 38.90  E-value: 6.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627836 632 ACRLVEAVLSGEVLNGAAVVRPPGHHAEqdaacgfcfFNSVAVAarHAQTISghalRILIVDWDVHHGNGTQHMF--EDD 709
Cdd:cd09987    10 AHELLAGVVVAVLKDGKVPVVLGGDHSI---------ANGAIRA--VAELHP----DLGVIDVDAHHDVRTPEAFgkGNH 74

                          90
                  ....*....|..
gi 2462627836 710 PSLTQNWCWSQL 721
Cdd:cd09987    75 HTPRHLLCEPLI 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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